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MitoCom O2k-Fluorometer Report 2011-2014
Dissemination
Public awareness
Year 3:
- eco.nova tirol innovativ - November 2014
- Tiroler Wirtschaft - August 2014
- Weekend Magazin Tirol - July 2014
- tiroler LANDESZEITUNG - May 2014
- TWInside - April 2014
- Branchenkatalog Mitocom Tyrol, OROBOROS INSTRUMENTS WGT Elektronik GmbH & Co KG - July 2013
- MUI Thema July 3rd
- Forum MedizinUni - June 20th, 2013
- mypoint MUI - June 20th, 2013
- Tiroler Tageszeitung - May 29th, 2013
Year 2:
- Standort 04/2012 2012
- zukunft forschung 2012
- K-Regio Folder 2012
- Forum MedizinUni, Beilage der Tiroler Tageszeitung - June 14th, 2012
- Freizeit Kurier-Artikel: Kraftwerk - June 2nd, 2012
- EURAC Bozen - June 1st, 2012
- Standard-Artikel:Neues Licht auf das Körperkraftwerk - May 16th, 2012
Year 1:
- Houska Preis 2011 - Siegerprojekt:
- PrÀsentation Science2Business
- Vortrag Berlin
- K-Regio beim Land Tirol
- K-Regio Standort Artikel I
- Die_Kraftwerke_der_Zellen Standort Artikel II
Overview on internet presentations of K-Regio MitoCom
- MitoCom_O2k-Fluorometer
- OROBOROS INSTRUMENTS: http://www.oroboros.at/index.php?mitocom-tyrol
MitoCom Workshops
- O2k-Workshop on HRR and O2k-Fluorometry, 2014 October 07-12, Schroecken, Tryol (AT)
- O2k-Fluorometry Workshop (advanced), 2014 September 12-16, Obergurgl, Tyrol (AT)
- O2k-Basic Workshop 2014 April 07-12, Schroecken, Voralberg (AT)
- O2k-Basic Workshop2013 Oct 9-14, Schroecken, Voralberg (AT)
- O2k-Fluorometry Workshop2013 Sept 19-23, Obergurgl, Tyrol (AT)
- intern: MitoCom Workshop May 16
- O2k-Workshop IOC66 O2k-Fluorescence and High-Resolution Respirometry. 2012 March 15 to 16; Innsbruck, Austria. - Feedback
Publications K-Regio MitoCom
International peer-reviewed journals
- G, Fontana-Ayoub M, Sumbalova Z, Heidler J, Gauper K, Fasching M, Gnaiger E (2014) Simultaneous high-resolution measurement of mitochondrial respiration and hydrogen peroxide production. Methods Mol Biol [in press.]
- Krumschnabel G, Eigentler A, Fasching M, Gnaiger E (2014) Use of safranin for the assessment of mitochondrial membrane potential by high-resolution respirometry and fluorometry. Methods Enzymol 542: 163-181.
- Votion DM, Gnaiger E, Lemieux H, Mouithys-Mickalad A, Serteyn D (2012) Physical fitness and mitochondrial respiratory capacity in horse skeletal muscle. PLoS One 7(4): e34890.
- Kristiansen G, Hu J, Wichmann D, Stiehl DP, Rose M, Gerhardt J, Bohnert A, ten Haaf A, Moch H, Raleigh J, Varia MA, Subarsky P, Scandurra FM, Gnaiger E, Gleixner E, Bicker A, Gassmann M, Hankeln T, Dahl E, Gorr TA (2012) Endogenous myoglobin in breast cancer is hypoxia-inducible by alternate transcription and functions to impair mitochondrial activity: a role in tumor suppression? J Biol Chem 286: 43417-43428
- Lemieux H, Semsroth S, Antretter H, Hoefer D, Gnaiger E (2011) Mitochondrial respiratory control and early defects of oxidative phosphorylation in the failing human heart. Int J Biochem Cell Biol 43: 1729â1738.
- Pesta D, Hoppel F, Macek C, Messner H, Faulhaber M, Kobel C, Parson W, Burtscher M, Schocke M, Gnaiger E (2011) Similar qualitative and quantitative changes of mitochondrial respiration following strength and endurance training in normoxia and hypoxia in sedentary humans. Am J Physiol Regul Integr Comp Physiol 301: R1078âR1087.
MiPNet Publications
- MiPNet19.20 Amplex Red Data Acquisition and Analysis
- MiPNet19.19 Safranin Data Acquisition and Analysis
- MiPNet18.06 Amplex-Yeast
- MiPNet18.05 Amplex-Mouse-heart
- MiPNet17.18._Gnaiger E (2012) Mitochondrial Pathways and Respiratory Control. An Introduction to OXPHOS Analysis. ISBN: 978-3-9502399-6-6
- MiPNet17.17 Amplex-Mouse-brain
- MiPNet17.16 O2k-Spectrophotometry
- MiPNet17.12_Bioblast 2012: Mitochondrial Competence. ISBN 978-3-9502399-5-9
- MiPNet17.06_IOC66_2012-03_Innsbruck
- G MiPNet17.05 O2k-Fluorescence LED2-Module
- MiPNet17.04_CitrateSynthase
- MiPNet17.03_Shredder_vs_Fibres
- MiPNet17.02_PBI-Shredder-Manual
Abstracts: Invited lectures at international conferences
- Gnaiger E, SĂžndergaard H, Munch-Andersen T, Damsgaard R, Hagen C, DĂez-SĂĄnchez C, Ara I, Wright-Paradis C, Schrauwen P, Hesselink M, Calbet J, Christiansen M, Helge JW, Saltin B, Boushel R (2013) Conserved Mitochondrial Coupling Efficiency and Adaptive Substrate Control in Inuit and Caucasians: Adaptation and Acclimatization to the Arctic Winter. Abstract Mito2013, Tokyo, JP. November 6-7
- Laner V, Gradl P, Eigentler A, Fontana-Ayoub M, Fasching M, Gnaiger E (2013) The OROBOROS Oxygraph-2k for High-Resolution Respirometry and O2k-Fluorometry: A New Quality in OXPHOS Analysis. Luncheon Seminar Abstract ASMRM 2013, Seoul, KR. November 4-5.
- Gnaiger E (2013)Loss of mitochondrial competence and degenerative disease: cause and effect. Abstract ASMRM 2013, Seoul, KR. November 4-5.
- Gnaiger E (2013) Biochemical coupling efficiency in permeabilized fibres from arm and leg muscle in Inuit versus Caucasians: A functional test of the uncoupling hypothesis in Greenland. Abstract MiP2013, Obergurgl, Austria. September 23-27.
- Gnaiger E (2013) Body mass index and the risk of neurodegeneration: from mitochondrial fitness to brain function. Abstract Neurocon 2013, Santiago Kolkata, India. Symposium: Neurocon 2013. January 17-20.
- Gnaiger E (2012) Aging and mitochondrial physiology. The effect of exercise and caloric balance on oxidative phosphorylation (OXPHOS). Abstract FEPS, Santiage de Compostela, Spain. Symposium: Advances in Aging and Mitochondria Research. September 08-12.
- Gnaiger E, Wright-Paradis C, Sondergaard H, Calbet J, Damsgaard R, Munck-Andersen T, Saltin B, Boushel R (2011) Conserved Mitochondrial Coupling and Adaptive Substrate Control in Inuit and Caucasians: Acclimatization to Active Life Styles in the Arctic Winter. Abstract SMRM, Hyderabad, India.
- Gnaiger E (2011) Fewer mitochondria - mitochondrial 'fever': Mitochondrial physiology and capacity of oxidative phosphorylation in active and sedentary life styles. Abstract Targeting Mitochondria, Berlin, DE.
- Sumbalova Z, Wiethuechter A, Fasching M, Gnaiger E (2011) Coupling control and substrate control of mitochondrial membrane potential and respiration in the mouse brain, and comparison with skeletal and cardiac muscle. Abstract MiP2011 Bordeaux, FR.
- Sumbalova Z, Harrison DK, Gradl P, Fasching M, Gnaiger E (2011) Mitochondrial membrane potential, coupling control, H2O2 production, and the upper limit of mitochondrial performance. Abstract Kagoshima, Japan.
Abstracts: Poster presentations at international conferences
- Lemieux H, Semsroth S, Antretter H, Hoefer D, Gnaiger E (2011) Increased OXPHOS capacity after cold preservation of the human heart â a paradox resolved by a dyscoupling mechanism. Abstract MiP2011 Bordeaux, FR.
- Fasching M, Harrison DK, Tretter L, Gnaiger E (2011) Combination of high-resolution respirometry and fluorometry for continuous monitoring of hydrogen peroxide production by mitochondria with resolution in the nanomolar range. Abstract MiP2011, Bordeaux, FR; and Targeting Mitochondria, Berlin, DE.
- Pesta D, Wiethuechter A, Karall D, Schocke M, Gnaiger E (2011) Functional mitochondrial diagnosis in a patient suffering from sudden exercise intolerance. Abstract Mitochondrial Medicine Chicago.
- Pesta D, Hoppel F, Macek C, Messner H, Faulhaber M, Kobel C, Parson W, Burtscher M, Schocke M, Gnaiger E (2011) Mitochondrial improvements after strength, endurance, and intermittend hypoxic training in sedentary humans. A respiratory study on permeabilized muscle fibres. Abstract Mitochondrial Medicine Chicago, USA.
- Sumbalova Z, Fasching M, Gnaiger E (2011) Substrate control in mitochondrial respiration and regulation of mitochondrial membrane potential. Abstract Mitochondrial Medicine Chicago.
- Burtscher M, Dietrich H, Gatterer H, Gnaiger E, Harrison DK, Karall D, Krismer M, Lass-Floerl C, Parson W, Perkhofer S, Pesta D, Schocke M, Sumbalova Z, WiethĂŒchter A (2011) Mitochondrial competence. Regional and international cooperation for establishing new standards in functional mitochondrial diagnosis. Abstract Mitochondrial Medicine Chicago, USA.
Exhibitions at international conferences
- 2014-07-12 to 15: EBEC2014, Lisbon, PT Erich Gnaiger
- 2014-06-04 to 07: EUROMIT2014, Tampere, FI: Erich Gnaiger, Verena Laner
- 2014-05-15 to 19: UMDF2014, Pittsburgh, US: Erich Gnaiger, Verena Laner
- 2014-05-25 to 31: World Congress on High Altitude Medicine and Physiology (ISMM2014), Bolzano, IT: Erich Gnaiger, Verena Laner
- 2014-01-27 to 30: 38th Mahabaleshwar Seminar, Mahabaleshwar, IN: Erich Gnaiger
- 2013-12-10 to 11: Exercise in Medicine, Trondheim
- 2013-12-19 to 21: SMRM2013, Bangalore, India: With an integrated O2k-Workshop IOC83 Erich Gnaiger
- 2013-11-06 to 07: Mitochondria2013, Tokyo, JP: Erich Gnaiger, Verena Laner
- 2013-11-04 to 05: ASMRM, Seoul, KR: Invited lectured and luncheon seminar Erich Gnaiger.
- 2013-09-23 to 27: MiP2013 Obergurgel, Austria. Erich Gnaiger, abstract presentation
- 2013-06-12 to 15: UMDF2013
- 2013-02-18: Clinical Hypothermia and Mitochondrial Function Verena Laner, Erich Gnaiger
- 2013-01-17 to 20: Neurocon 2013, Kolkata, IN: Verena Laner, Erich Gnaiger
- 2013-01-14 to 16: Pre-conference O2k-Workshop Neurocon 2013, Kolkata, IN: Verena Laner, Erich Gnaiger
- 2012-12-05 to 10: IOC72 Tutoring Mona Fontana-Ayoub
- 2012-09-15 to 20: EBEC 2012, Freiburg i. Breisgau, DE: Katrin Stecher, Verena Laner, Erich Gnaiger
- 2012-05-07: O2k-Fluorometry Mitolab Workshop Madrid: Erich Gnaiger
- 2012-03-15 to 16: IOC66 - O2k-Fluorescence. An International O2k-Workshop of MitoCom Tyrol.
- 2011-10-20 to 21: Targeting Mitochondria, Berlin, DE. Exhibition of OROBOROS INSTRUMENTS and MitoCom Tyrol: Katrin Stecher, Lydia Staudacher.
- 2011-09-05 to 04: MiP2011 Bordeaux, France. Exhibition of OROBOROS INSTRUMENTS and MitoCom Tyrol: Katrin Stecher, Lydia Staudacher.
- 2011-08-31 to 09-04: Kagoshima, Japan. Exhibition of the OROBOROS Oxygraph-2k. Yoshiaki Nakayoshi, Sanyo Trading Co. Ltd., Tokyo, JP and Erich Gnaiger, OROBOROS INSTRUMENTS, AT.
- 2011-06-15 to 18: UMDF Mitochondrial Medicine 2011 - Chicago, US. Exhibition of OROBOROS INSTRUMENTS and MitoCom Tyrol. Katrin Stecher, Dominik Pesta, Erich Gnaiger.
Exhibitions and presentations at regional and national events
- 2012-11-06: MCI Forum Biotechnologie
- 2012-09-27: Tiroler Standort Lunch in Wien
- 2012-09-20: Tiroler Medizintechnikforum
International cooperations
Semmelweiss Univ. Budapest, HU
Project meeting with L. Tretter, G. Horvath, A. Nagy, T. Komlodi, V. Laner and E. Gnaiger
Duration: 2014-07-20 to 24
Location: Budapest, Hungary
O2k-Network Lab: HU_Budapest_Tretter_L
Univ. Granada, ES
Carolina Doerrier Velasco was working in the D. Swarovski Research Laboratory between September 19th and December 19th, 2011. The scientific visit aimed at improving her professional skills in the field of high resolution respirometry (HRR) based on her involvement in protocol development of the Network MitoCom Tyrol (www.bioblast/MitoCom).
Zewail City for Science and Technology, ET
Two sudents of Prof. Ali Sameh (O2k-Network Lab: ET_Giza_Ali_SS) were working for two months at the D. Swarovski Lab and focused on their individual projects, learnig high-resolution respirometry.
- Islam Abo El Yazeed Kotb (Egypt): Apr 15 to Jun 10,
- Abdel Rahman Medhat Khalifa (Egypt): Apr 15 to Jun 10,
see: Visiting_Scientists#April_2013
University of Cambdrige, UK
Xtreme Everst 2 - high-altitude research in Nepal
Dr. Erich Gnaiger and Verena Laner participated at the Xtreme Everest 2 Expedition in Nepal.
Erich Gnaiger (Innsbruck, AT) joined the Xtreme Everest 2 mitochondrial team at Everest Base Camp (5,300 m) where acclimation to high altitude was studied using three O2k (March to May 2013). In Kathmandu (Nepal) at low altitude (1,400 m), Andrew Murray (Cambridge, UK) operated high-resolution respirometry on human musle biopsies with assistance by Verena Laner (Innsbruck, AT).
More infomation: Xtreme Everest 2
Some impressions of the Expedition:
The participants from Innsbruck are supported by the K-Regio project MitoCom Tyrol, D. Swarovski Research Laboratory (Medical University of Innsbruck), and OROBOROS INSTRUMENTS.
The project "Light in the powerhouse of the cell - the O2k-Fluorometer" has been nominated for the Tyrolean Innovation Award! see pdf (in German)
Das Projekt "Licht in die Kraftwerke der Zellen - das O2k-Fluorometer" wurde fĂŒr den Tiroler Innovationspreis nominiert! siehe pdf
MitoCom Track Record 2014
When | Where | |
---|---|---|
MitoCom2014 | 2014-10-16 | Innsbruck AT, 2014 Oct 16. MitoCom Tyrol - a success story. |
MiPNet19.10 IOC95 Obergurgl | 2014-09-12 | Obergurgl AT, 2014 Sep 12-16. Oroboros O2k-Workshop on O2k-Fluorometry, IOC95 at MiP2014. |
EBEC2014 | 2014-07-12 | Lisbon PT, 2014 Jul 12-17. 18th European Bioenergetics Conference - EBEC2014 Harrison DK, Fasching M, Fontana-Ayoub M, Gnaiger E (2014) The relationship between cytochrome redox state and oxygen consumption in isolated mouse and beef heart mitochondria during hypoxia. EBEC2014. Krumschnabel G, Eigentler A, Fasching M, Gnaiger E (2014) Combined high-resolution respirometry and fluorometry. Validation of safranin for determination of mitochondrial membrane potential. EBEC2014. |
MiPNet19.09 IOC94 Shanghai CN | 2014-06-27 | Shanghai CN, 2014 Jun 27-Jul 02. Oroboros O2k-Workshop on HRR and O2k-Fluorometry, IOC94. Oroboros representative in China: »CN Shanghai Zenda. |
MiPNet19.08 IOC93 | 2014-06-17 | Tampere FI, 2014 Jun 17. Oroboros O2k-Lunch Workshop on HRR and O2k-Fluorometry, IOC93 at EUROMIT2014. |
EUROMIT2014 | 2014-06-15 | Tampere FI, 2014 Jun 15-19. International Meeting on Mitochondrial Pathology - EUROMIT 2014. |
MiPNet19.07 IOC92 | 2014-06-05 | Pittsburgh US, 2014 Jun 04-07. OROBOROS O2k-Lunch Workshop on HRR and O2k-Fluorometry, IOC92 at UMDF2014. |
UMDF2014 | 2014-06-04 | Pittsburgh US, 2014 Jun 04-07. Mitochondrial Medicine, UMDF2014. |
MiPNet19.06 IOC91 Philadelphia US | 2014-06-02 | Philadelphia US, 2014 Jun 02-03. Oroboros O2k-Workshop on HRR and O2k-Fluorometry, IOC91. O2k-Network Lab »US PA Philadelphia Wallace DC. |
MiPNet19.05 IOC90 Bolzano IT | 2014-05-27 | Bolzano IT, 2014 May 27. Applied Workshop - High-resolution respirometry and mitochondrial function under hypoxia: overview, demo experiment and discussion. IOC90 at ISMM2014. |
ISMM2014 | 2014-05-25 | Bolzano IT, 2014 May 25-31. World Congress on High Altitude Medicine and Physiology, ISMM2014. |
MiPNet19.04 IOC89 La Jolla US | 2014-05-01 | La Jolla US, 2014 May 01-02. Oroboros O2k-Workshop on HRR and O2k-Fluorometry, IOC89. O2k-Network Lab »US CA La Jolla Felding-Habermann B |
EB2014 | 2014-04-26 | San Diego US, 2014 Apr 26-30. Symposium for Experimental Biology, EB2014. |
MiPNet19.02 IOC88 Schroecken AT | 2014-04-07 | Schroecken AT, 2014 Apr 07-12. Oroboros O2k-Workshop on HRR and O2k-Fluorometry, IOC88. |
Long Night of Research 2014 | 2014-04-04 | Innsbruck AT, 2014 Apr 04. OROBOROS at Long Night of Research and Science, CCB. |
MiPNet18.16 IOC87 Spitsbergen | 2014-03-24 | Spitsbergen NO, 2014 Mar 24-27. Oroboros O2k-Workshop on HRR and O2k-Fluorometry: Spitsbergen - Enjoy the Cold, IOC87. MiPNet Lab »NO Trondheim Rognmo O. |
MiPNet18.15 IOC86 | 2014-01-31 | Mumbay IN, 2014 Jan 31. Oroboros O2k-Workshop on HRR and O2k-Fluorometry, IOC86. »IN Mumbai Kolthur-Seetharam U |
MiPNet18.14 IOC85 | 2014-01-28 | Mahabaleshwar IN, 2014 Jan 28-30. OROBOROS O2k-Workshop on HRR and O2k-Fluorometry, IOC85 at 38th Mahabaleshwar Seminar. MiPNet Lab »IN Mumbai Kolthur-Seetharam U. |
38th Mahabaleshwar Seminar | 2014-01-27 | Mahabaleshwar IN, 2014 Jan 27-30. Mitochondria, Metabolism and Energetics: 38th Mahabaleshwar Seminar. |
MiPNet18.13 IOC84 Alaska | 2014-01-04 | Big Lake, Alaska US, 2014 Jan 04-07. Oroboros O2k-Workshop on HRR and Racing dogs at Iditarod, IOC84. »US OK Stillwater Davis MS |
MitoCom Track Record 2013
O2k-Workshop, Bangalore, India, Dec 18 prior SMRM2013
A one-day O2k-Workshop on HRR and Fluorometry was given by Dr. Erich Gnaiger at the SMRM meeting in Bangalore.
O2k-Fluorometry Workshop, Trondheim, Norway, Dec 10-11
Dr. Erich Gnaiger and Verena Laner gave an O2k-Workshop, focused on the Fluorescence LED-2 Module prior the seminar 'Exercise in Medicine', which was organized by CERG of the NTNU University.
O2k-Luncheon Seminar, Seoul, Korea, Nov 05 @ ASMRM2013
Dr. Erich Gnaiger (Medical University of Innsbruck) followed the invitation of Prof. Hong Kyu Lee to give a talk at the ASMRM2013 meeting. Furthermore he took this opportunity to give an O2k-Luncheon Workshop on HRR and Fluorometry.
O2k-Fluorometry Workshop, Schroecken, Austria, Oct 09 - 14
A new concept, integrating the Flurometry-Workshop into the Basic-O2k-Workshop, was celebrated at the 80th O2k-Workshop in Schroecken. Tutors: Dr. Erich Gnaiger, Mona Fontana-Ayoub, Verena Laner and Gerhard Krumschnabel.
O2k-Fluorometry Workshop, Obergurgl, Austria, September 19-23
Prior MiP2013, a O2k-Fluorometry Workshop was given in Obergurgl by Dr. Erich Gnaiger, Dr. Mario Fasching, Mona Fontana-Ayoub and Verena Laner. Hands-on sessions for ~30 participants on 6 O2ks.
O2k-Workshop @ MiPsummer, Copenhagen, DK, August 27-29
- IOC78 - Tutors: Dr. Erich Gnaiger and Verena Laner
O2k-Luncheon Seminar @ UMDF, Newport Beach, CA, US, June 13
Prof. Gottfried Schatz
Article of the Medical University of Innsbruck
O2k-Workshop, Prague, Austria, May 28 - 29
The workshop is organized by Faculty of Science UK (Doc. M. Kalous and Dr. J. ĆœurmanovĂĄ) in cooperation with the Institute of Physiology AVCR (Dr. Z. Drahota and Dr. J. HouĆĄtÄk) and Medical Faculty UK in Hradec KrĂĄlovĂ© (Prof. Z. ÄervinkovĂĄ). Dr. Gnaiger was invited on the occasion of We invite you to the occasion of purchasing two new OROBOROS O2k supported bhe the Fund for Universite's Development. The workshop provided an introduction to the Oxygraph-2k and MultiSensor technologies (e.g. the O2k-Fluorescence LED2-Module, which was developped within the K-Regio Project MitoCom Tyrol).
O2k-Workshop, Schroecken, Austria, Apr 09 - 14
O2k-TPP-Workshop, Innsbruck, Austria, Jan 22 - 25
O2k-Workshop, Kolkata, India, January 15 - 16
Dr. Erich Gnaiger - accompanied by Mag. Verena Laner (Oroboros Instruments) - participated at the Neurocon 2013 in Kolkata. Prior the conferece, an O2k-Workshop on high-resolution respirometry and O2k-Fluorometry was held for approx. 30 participants.
MitoCom Track Record 2012
O2k-Workshop, Schroecken, Austria, Dec 5 - 10
Bioblast 2012 - Conference on Mitochondrial Competence
The Bioblast Conference 2012 took place in Hotel Grauer BĂ€r from 10th to 12th December 2012. With more than 70 participants from 19 nations the conference was a great success.
For the article of the Medical University Innsbruck, see: MUI website
More information: Bioblast 2012
Padua Muscle Days, Nov 23 - 25
After the satellite meeting in Vienna on October 17th, Prof. Dr. Gnaiger was invited by Prof. Dr. Ugo Carraro (University of Padua) to Padua for a talk on high-resolution respirometry in permeabilized fibers from small biopsies of human muscle.
MCI Forum Technologie & Life Sciences, Innsbruck, Nov 6
In her talk, Mag. Verena Laner will outline the development of the company OROBOROS INSTRUMENTS and will walk you through the early company days up to the current K-Regio Project MitoCom Tyrol. Programme
Satellite Meeting Vienna, Oct 17
Dr. Erich Gnaiger participated at the Satellite Meeting in Vienna, which took place on 17th October.
Attendees of this meeting were Delegates of the University in Padua (Univ.-Prof. Dr. Ugo Carraro and Dr. Sandra Zampieri), University in Chieti (Univ.-Prof. Dr. Protasi) and University in Rome (Univ.-Prof. Dr. Andrea Musaro).
The meeting was organized by Dr. Kern from the Ludwig Boltzmann Institute in Vienna.
Standort Lunch Vienna, 2012 Sep 27
Dr. Erich Gnaiger presented the MitoCom project at the Standort Lunch in Vienna, organized by the Standortagentur Tirol. More information.
The article of the STANDORT Tirol you can find in issue no. 15, page 8
Medizintechnikforum Hall, 2012 Sep 20 to 21
OROBOROS INSTRUMENTS exhibited at the Medizintechnikforum Hall, showing latest developments in high-resolution respirometry in combination with the O2k-Fluorescence LED2-Module. MitoCom Tyrol was presented together with the Open Innovation project, both supported by the Government of Tyrol.
Tiroltag, EuropÀisches Forum Alpbach, 2012 Aug 19
Verena Laner, the project manager of MitoCom Tyrol, took part at the Tirolday, which was the "Opening" of the European Congress in Alpbach 2012. The main topic was "The future of sports in the Alps", which is an integral part of the MitoCom project. Additionally to the presentations and the award presentation ceremony for young scientists, there was a podium discussion with well-known experts such as the famous alpinist Reinhard Messner.
MitoCom Cooperation AltitudeOmics 2012, 2012 July 20 to Aug 13
Dr. Erich Gnaiger participated in the AltitudeOmics2012 project in Bolivia and provided the scientists with two O2ks and his expertise. Aim of the study was to investigate the impacts of hypoxia/acclimatization onto molecular mechanisms of the human cells.
Visiting scientist: Prof. Dr. Fr. Baby Joseph, July 19
On July 19th, Prof. Dr. Fr. Baby Joseph visited the OROBOROS office.
Time schedule of the research visit
Houska Award 2011 - First price for MitoCom Tyrol, April 26
- First price - Medical University of Innsbruck: http://www.oroboros.at/?Houska-Award_2011
- http://www.houskapreis.at/siegerprojekt-2011-licht-in-die-kraftwerke-der-zellen
- http://www.houskapreis.at
- http://www.tt.com/Nachrichten/4702341-6/houska-preise-an-universit%C3%A4ten-in-innsbruck-und-graz.csp
Mitolab O2k-Fluorometry Workshop Madrid, Spain, May 7
- Mitolab Workshop by Erich Gnaiger
- Contact: Eduardo Rial (Email: [email protected]) and Susana Cadenas (Email: [email protected])
>> See also MitoCom_Tyrol - Report
O2k-Workshop Schröcken, Austria, April 11 to 16
O2k-Workshop Sydney, Australia, April 2 to 4
First O2k-Fluorometry Workshop, Innsbruck, March 15 to 16
- IOC66 O2k-Fluorometry Workshop. An International O2k-Workshop of MitoCom Tyrol.
Manuscript accepted for publication in PloS One, March 9
- "Physical fitness and mitochondrial respiratory capacity in horse skeletal muscle" (by Votion DM, Gnaiger E, Lemieux H, Mouithys-Mickalad A, Serteyn D) was accepted for publication in PloS One.
- From the anonymous referee's comments:
- Reviewer #1: "This is an original work performed with state of the art methodologies, as high-resolution respirometry. The results indicate that not only mitochondrial capacity is a limiting factor of horse performance but also the modalities of energy substrate utilization. Horse is an animal of choice for energetic studies since it shows a huge consumption of oxygen during muscle contraction, suggesting an positive adaptation of the mitochondrial system as compared to other animals. .. This article provides new findings on the link between mitochondrial capacity and whole animal body size and aerobic capacity. It also clarifies whether mitochondrial capacity is a controling factor for horse performance. An important finding is also that the control by the phosphorylation system is stable and does not vary with the performance of the horse. In contrast, the relative utilization of complex I versus complex II varies witht he performance, and this is a new finding which adds up to our knowledge of energy regulation. This work is of broad interest for sport physiology, metabolic researchers and aging research."
- Reviewer #2: "The results could be described in a much easier way if utilizing classical definitions of mitochondrial respiratory parameters (from the late Britton Chance's milestones), such as state IV (or II), state III, uncoupled respiration, respiratory control ratio and so on." (Comment: MitoPedia: Respiratory states)
MitoCom track record 2011
- See also: Science Calendar
2011-11-29: 9. Tiroler Innovationstag
- 13:00-14:30 Cluster-Partnertreffen LIFE SCIENCES Tirol
- Programm
- ab 12.30 Uhr: Treffen im Congress Innsbruck, 3. Stock
- 13.00 Uhr: BegrĂŒĂung DDr. Petra Stöckl (Programm Managerin Life Sciences Tirol)
- 13.05 Uhr: Die neue Clusterstrategie. Vorstellung der Eckdaten
- 13.20 Uhr: Vorstellung der Clusterpartner und Diskussion der Clusterstrategie
- 14.15 Uhr Vorstellung K-Regio MitoCom. Univ.-Prof. Dr. Erich Gnaiger (Oroboros)
- 15:00 m Tiroler Innovationstag - Programm
2011-11-19: An extension of Bioblast
- In addition to the MitoPedia: Respirometry, the MitoPedia: Fluorometry and MitoPedia: Spectrophotometry were initiated by David Harrison.
2011-11-11: Bioblast alert
- Bioblast alert was launched, for information purposes, not intended to be an advertisement.
2011-11-04: Product news
2011-November: MitoCom Lectures, Innsbruck
2011-10-20 to 21: Targeting Mitochondria, Berlin, DE
- Invited lecture: Erich Gnaiger - Gnaiger 2011 Abstract-Berlin
- Exhibition of OROBOROS INSTRUMENTS and MitoCom Tyrol: Katrin Stecher, Lyda Staudacher
2011-09-24: High-output to replace wasteful high-throughput?
2011-09-05 to 04: MiP2011 Bordeaux, France
- 8th Conference on Mitochondrial Physiology - MiP2011. Bordeaux, France.
- Invited lecture: Erich Gnaiger - Sumbalova 2011 Abstract Bordeaux
- Poster: Erich Gnaiger - Lemieux_2011_Abstract Bordeaux
- Poster: Mario Fasching - Fasching_2011_Abstract Bordeaux
- Exhibition of OROBOROS INSTRUMENTS and MitoCom Tyrol: Katrin Stecher, Lyda Staudacher
2011-08-31 to 09-04: KAGOSHIMA JAPAN
- 5th Biennial Meeting of Society for Free Radical Research (SFRR)-Asia, 8th Conference of Asian Society for Mitochondrial Research and Medicine (ASMRM), and 11th Conference of Japanese Society of Mitochondrial Research and Medicine (J-mit); Kagoshima CitizensÂŽCulture Hall, Kagoshima, Japan. Chair: Prof. Hideyuki J. Majima; E-mail: [email protected]
- Invited lecture: Erich Gnaiger - Sumbalova 2011 Abstract Kagoshima
- Exhibition of the OROBOROS Oxygraph-2k: Yoshiaki Nakayoshi, Sanyo Trading Co. Ltd., Tokyo, JP
2011-08-26 to 27: O2k-Workshop China
2011-08-12: Circular on MitoScore
MitoScore is an initiative of MitoCom:
2011-08-09: Manuscript accepted for publication in IJBCB
- "Mitochondrial respiratory control and early defects of oxidative phosphorylation in the failing human heart" (by Lemieux H, Semsroth S, Antretter H, Höfer D, Gnaiger E) was accepted for publication in Intl. J. Biochem. Cell Biol.
- From the anonymous referee's comments:
- Reviewer #1: "The manuscript by Lemieux and colleagues offers interesting insight into the bioenergetics of early phases of heart failure."
- Reviewer #2: "This is a beautifully written work, replete with well-designed experiments and, within the space limitations, a nice review of the pertinent literature. The demonstration of impaired mitochondrial fatty acid oxidation in early stages of human failure is very important, as is the demonstration of defects in the phosphorylation system and Complex I-linked respiration."
- Reviewer #3: "The manuscript belongs literally to the symphony of bioenergetics and have mastered on a maximum thorough and detailed level a priority study of human heart disease bioenergetics in an intermediate state of heart disease, which was done only scarcely in medical sciences and for this orthodox approach this work deserves a high attention. It elegantly describes detailed oxidative phosphorylation parameters in heart disease compared to the control human heart. Using high-resolution respirometry of permeabilized human heart muscle fibres authors progressively describe distinct aspect of measured data in logical steps to present important differences of diminished mitochondrial function during heart failure. Using elegant protocols developed for years, authors distinguish between phosphorylating (OXPHOS) and non-phosphorylating (ETS) conditions with both complex I and II input using physiological substrates of glucose and lipid oxidation. With presented protocols, authors are able to provide conclusions regarding, e.g., complex I impairment, phosphorylation system limitation (3.2) mitochondrial content (3.3), leak respiration involvement, etc., besides OXPHOS and ETS capacities. Authors use their own terminology describing respiratory states. It would be useful to explain briefly their terminology also in terms of the canonical state 2 - 4 terminology. In spite of this, the methodology approach and presented data are well explained."
2011-07-18: Informal MitoCom-MiPArt 18:18
- Monday, July 18 â 18:18 h â Schöpfstr. 18 â we thank our guests for sharing a friendly 18:18 evening with us.
- Informal get-together at 'Oroboros' - science and art - celebrate a "beautifully written work" - a "symphony of bioenergetics" (see 2011-08-09).
- Celebrate the official acceptance of K-Regio MitoCom Tyrol.
- Explore future perspectives.
2011-07-12: The K-Regio MitoCom project - accepted
- The project application MitoCom Tyrol was officially accepted.
2011-07-12: Manuscript accepted in AJP
- "Similar qualitative and quantitative changes of mitochondrial respiration following strength and endurance training in normoxia and hypoxia in sedentary humans" by Pesta D, Hoppel F, Macek C, Messner H, Faulhaber M, Kobel C, Parson W, Burtscher M, Schocke M, Gnaiger E, was accepted for publication in Am. J. Physiol. Regul. Integr. Comp. Physiol. (http://www.ncbi.nlm.nih.gov/pubmed/21775647).
- From the anonymous referee's comments: This is really a superb revision; the MS has been improved substantially, particularly with reference to the theory and methods re: the HRR.
2011-07-11 to 13: Introductory O2k-Workshop (IOC62) - MitoCom Tyrol
- Location: OROBOROS INSTRUMENTS, Schöpfstr. 18, Innsbruck, Austria.
- More informatio: IOC62
2011-06-15 to 18: UMDF Mitochondrial Medicine 2011 - Chicago, US
- Poster: Erich Gnaiger - Burtscher 2011 AbstractUMDFChicago
- Poster: Dominik Pesta - Pesta_2011_AbstractUMDFChicago-Training
- Poster: Dominik Pesta - Pesta_2011_AbstractUMDFChicago-Diagnosis
- Exhibition of OROBOROS INSTRUMENTS and MitoCom Tyrol: Katrin Stecher, Dominik Pesta, Erich Gnaiger
2011-05-18: MiPArt - Mitochondria - the Aliens in our Cells
MiPArt - Mitochondria - the Aliens in our Cells
- Exhibition (Odra Noel, Richard Altmann and others)
- Presentation of MitoCom Tyrol
2011-05-01: Start K-Regio Project MitoCom Tyrol
Workshops towards MitoCom 1
Management
- 2011-10-30: ORO installed an 'Intern wiki' for communication, documentation and organization of the K-Regio Project MitoCom.