Gnaiger E

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Evolution-Age-Gender-Lifestyle-Environment  » COST Action CA15203 Mitochondrial fitness mapping

Gnaiger E


MitoPedia topics: EAGLE 

COST: Member COST WG1: WG1 COST WG2: WG2 COST WG3: WG3 COST WG4: WG4

Chair - Management Committee MITOEAGLE
Name Gnaiger Erich, Ao.Univ.-Prof. PhD, CEO
Institution
Erich Gnaiger

Daniel Swarovski Research Laboratory

Department of Visceral, Transplant and Thoracic Surgery

Medical University of Innsbruck

Combination of interests: science and corporation

OROBOROS INSTRUMENTS Corp.

O2k high-resolution respirometry

The joy of success is the next step.
Address Schöpfstrasse 18, A-6020
City Innsbruck
State/Province
Country Austria
Email erich.gnaiger@oroboros.at
Weblink www.oroboros.at, www.bioblast.at, www.mitophysiology.org
O2k-Network Lab AT Innsbruck Gnaiger E, AT Innsbruck MitoFit, AT Innsbruck OROBOROS


Labels: Field of research: Basic  Topics: High-resolution respirometry, MitoPedia: high-resolution terminology 


Publications

Published Reference
Cabrera-Fuentes 2016 Basic Res Cardiol 2016 Cabrera-Fuentes HA, Aragones J, Bernhagen J, Boening A, Boisvert WA, Bøtker HE, Bulluck H, Cook S, Di Lisa F, Engel FB, Engelmann B, Ferrazzi F, Ferdinandy P, Fong A, Fleming I, Gnaiger E, Hernández-Reséndiz S, Kalkhoran SB, Kim MH, Lecour S, Liehn EA, Marber MS, Mayr M, Miura T, Ong SB, Peter K, Sedding D, Singh MK, Suleiman MS, Schnittler HJ, Schulz R, Shim W, Tello D, Vogel CW, Walker M, Li QO, Yellon DM, Hausenloy DJ, Preissner KT (2016) From basic mechanisms to clinical applications in heart protection, new players in cardiovascular diseases and cardiac theranostics: meeting report from the third international symposium on "New frontiers in cardiovascular research". Basic Res Cardiol 111:69.
Schoepf 2016 FEBS J 2016 Schöpf B, Schäfer G, Weber A, Talasz H, Eder IE, Klocker H, Gnaiger E (2016) Oxidative phosphorylation and mitochondrial function differ between human prostate tissue and cultured cells. FEBS J 283:2181-96.
Boushel 2015 Scand J Med Sci Sports 2015 Boushel R, Gnaiger E, Larsen FJ, Helge JW, Gonzalez-Alonso J, Ara I, Munch-Andersen T, van Hall G, Søndergaard H, Saltin B, Calbet JAL (2015) Maintained peak leg and pulmonary VO2 despite substantial reduction in muscle mitochondrial capacity. Scand J Med Sci Sports 25 (Suppl 4):135–43.
Harrison 2015 J Appl Physiol 2015 Harrison DK, Fasching M, Fontana-Ayoub M, Gnaiger E (2015) Cytochrome redox states and respiratory control in mouse and beef heart mitochondria at steady-state levels of hypoxia. J Appl Physiol 119:1210-8.
Dueregger 2015 PLoS One 2015 Dueregger A, Schöpf B, Eder T, Höfer J, Gnaiger E, Aufinger A, Kenner L, Perktold B, Ramoner R, Klocker H, Eder IE (2015) Differential utilization of dietary fatty acids in benign and malignant cells of the prostate. PLoS One 10(8):e0135704.
Krumschnabel 2015 Methods Mol Biol 2015
O2k-Protocols contents
Krumschnabel G, Fontana-Ayoub M, Sumbalova Z, Heidler J, Gauper K, Fasching M, Gnaiger E (2015) Simultaneous high-resolution measurement of mitochondrial respiration and hydrogen peroxide production. Methods Mol Biol 1264:245-61.
Burtscher 2015 Mitochondrion 2015 Burtscher J, Zangrandi L, Schwarzer C, Gnaiger E (2015) Differences in mitochondrial function in homogenated samples from healthy and epileptic specific brain tissues revealed by high-resolution respirometry. Mitochondrion 25:104-12.
Gnaiger 2015 Scand J Med Sci Sports 2015 Gnaiger E, Boushel R, Søndergaard H, Munch-Andersen T, Damsgaard R, Hagen C, Díez-Sánchez C, Ara I, Wright-Paradis C, Schrauwen P, Hesselink M, Calbet JAL, Christiansen M, Helge JW, Saltin B (2015) Mitochondrial coupling and capacity of oxidative phosphorylation in skeletal muscle of Inuit and caucasians in the arctic winter. Scand J Med Sci Sports 25 (Suppl 4):126–34.
Makrecka-Kuka 2015 Biomolecules 2015
O2k-Protocols contents
Makrecka-Kuka M, Krumschnabel G, Gnaiger E (2015) High-resolution respirometry for simultaneous measurement of oxygen and hydrogen peroxide fluxes in permeabilized cells, tissue homogenate and isolated mitochondria. Biomolecules 5:1319-38.
Blatzer 2015 Antioxid Redox Signal 2015 Blatzer M, Jukic E, Posch W, Schöpf B, Binder U, Steger M, Blum G, Hackl H, Gnaiger E, Lass-Flörl C, Wilflingseder D (2015) Amphotericin B resistance in Aspergillus terreus is overpowered by co-application of pro-oxidants. Antioxid Redox Signal 23:1424-38.
Larsen 2014 Anal Biochem 2014 Larsen S, Kraunsøe R, Gram M, Gnaiger E, Helge JW, Dela F (2014) The best approach: homogenization or manual permeabilization of human skeletal muscle fibers for respirometry? Anal Biochem 446:64-8.
Boushel 2014 Acta Physiol (Oxf) 2014 Boushel RC, Ara I, Gnaiger E, Helge JW, Gonzalez-Alonzo J, Munck-Andersen T, Sondergaard H, Damsgaard R, van Hall G, Saltin B, Calbet JA (2014) Low intensity training increases peak arm VO2 by enhancing both convective and diffusive O2 delivery. Acta Physiol (Oxf) 211:122-34.
Krumschnabel 2014 Methods Enzymol 2014
O2k-Protocols contents
Krumschnabel G, Eigentler A, Fasching M, Gnaiger E (2014) Use of safranin for the assessment of mitochondrial membrane potential by high-resolution respirometry and fluorometry. Methods Enzymol 542:163-81.
Khan 2014 J Comp Physiol 2014 Khan JR, Iftikar FI, Herbert NA, Gnaiger E, Hickey AJ (2014) Thermal plasticity of skeletal muscle mitochondrial activity and whole animal respiration in a common intertidal triplefin fish, Forsterygion lapillum (Family: Tripterygiidae). J Comp Physiol 184:991-1001.
Gnaiger 2014 MitoPathways 2014
O2k-Protocols
Gnaiger E (2014) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 4th ed. Mitochondr Physiol Network 19.12. OROBOROS MiPNet Publications, Innsbruck:80 pp.
Chicco 2014 J Exp Biol 2014 Chicco AJ, Le CH, Schlater AE, Nguyen AD, Kaye SD, Beals JW, Scalzo RL, Bell C, Gnaiger E, Costa DP, Crocker DE, Kanatous SB (2014) High fatty acid oxidation capacity and phosphorylation control despite elevated leak and reduced respiratory capacity in northern elephant seal muscle mitochondria. J Exp Biol 217:2947-55.
Laner 2014 Mitochondr Physiol Network MiP2014 2014
MiPsociety
Laner V, Gnaiger E, eds (2014) Mitochondrial physiology – methods, concepts and biomedical perspectives. MiP2014. Mitochondr Physiol Network 19.13:88 pp. ISBN 978-3-9502399-9-7
Jacobs 2013 Exp Physiol 2013 Jacobs R, Boushel RC, Wright-Paradis C, Calbet JA, Robach P, Gnaiger E, Lundby C (2013) Mitochondrial function in human skeletal muscle following high altitude exposure. Exp Physiol 98:245-55.
MiPNet18.08 MiP2013 2013
MiPsociety
Laner V, Bidaurratzaga E, Gnaiger E, eds (2013) Comparative Mitochondrial Physiology. MiP2013. Mitochondr Physiol Network 18.08:96 pp. ISBN 978-3-9502399-7-3
Votion 2012 PLoS One 2012 Votion DM, Gnaiger E, Lemieux H, Mouithys-Mickalad A, Serteyn D (2012) Physical fitness and mitochondrial respiratory capacity in horse skeletal muscle. PLoS One 7:e34890.
Robach 2012 Br J Sports Med 2012 Robach P, Siebenmann C, Jacobs R, Rasmussen P, Nordsborg N, Pesta D, Gnaiger E, Diaz V, Christ A, Fiedler J, Crivelli N, Secher NH, Pichon A, Maggiorini M, Lundby C (2012) The role of haemoglobin mass on VO2max following normobaric live high-train low in endurance-trained athletes. Br J Sports Med Jul 12. 46:822-7.
Pesta 2012 Methods Mol Biol 2012
O2k-Protocols
Pesta D, Gnaiger E (2012) High-resolution respirometry. OXPHOS protocols for human cells and permeabilized fibres from small biopsies of human muscle. Methods Mol Biol 810:25-58.
Burtscher 2012 High Alt Med Biol 2012 Burtscher M, Gnaiger E, Burtscher J, Nachbauer W, Brugger A (2012) Arnold Durig (1872-1961): life and work. An Austrian pioneer in exercise and high altitude physiology. High Alt Med Biol 13:224-31.
Iyer 2012 Hum Gene Ther 2012 Iyer S, Bergquist K, Young K, Gnaiger E, Rao RR, Bennett JP Jr (2012) Mitochondrial gene therapy improves respiration, biogenesis and transcription in G11778A Leber’s hereditary optic neuropathy and T8993G Leigh’s syndrome cells. Hum Gene Ther 23:647-57.
Gnaiger 2012 Mitochondr Physiol Network Bioblast 2012 2012
OROBOROS
Gnaiger E, Meissner B, Laner V, eds (2012) Bioblast 2012: Mitochondrial Competence. Mitochondr Physiol Network 17.12. OROBOROS MiPNet Publications, Innsbruck:96 pp. ISBN 978-3-9502399-5-9
Gnaiger 2012 MitoPathways 2012
O2k-Protocols.jpg
Gnaiger E (2012) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 3rd ed. Mitochondr Physiol Network 17.18. OROBOROS MiPNet Publications, Innsbruck:64 pp. ISBN 978-3-9502399-6-6 (see 4th edition: Gnaiger 2014 MitoPathways).
Larsen 2012 CryoLetters 2012 Larsen S, Wright-Paradis C, Gnaiger E, Helge JW, Boushel RC (2012) Cryopreservation of human skeletal muscle impairs mitochondrial function. Cryo Letters 33:170-6.
Pesta 2011 Am J Physiol Regul Integr Comp Physiol 2011 Pesta D, Hoppel F, Macek C, Messner H, Faulhaber M, Kobel C, Parson W, Burtscher M, Schocke M, Gnaiger E (2011) Similar qualitative and quantitative changes of mitochondrial respiration following strength and endurance training in normoxia and hypoxia in sedentary humans. Am J Physiol Regul Integr Comp Physiol 301:R1078–87.
Jacobs 2011 J Appl Physiol 2011 Jacobs R, Rasmussen P, Siebenmann C, Díaz V, Pesta D, Gnaiger E, Nordsborg NB, Robach P, Lundby C (2011) Determinants of time trial performance and maximal incremental exercise in highly trained endurance athletes. J Appl Physiol 111:1422–30.
Lemieux 2011 Int J Biochem Cell Biol 2011 Lemieux H, Semsroth S, Antretter H, Höfer D, Gnaiger E (2011) Mitochondrial respiratory control and early defects of oxidative phosphorylation in the failing human heart. Int J Biochem Cell Biol 43:1729–38.
Boushel 2011 Mitochondrion 2011 Boushel RC, Gnaiger E, Calbet JA, Gonzalez-Alonso J, Wright-Paradis C, Sondergaard H, Ara I, Helge JW, Saltin B (2011) Muscle mitochondrial capacity exceeds maximal oxygen delivery in humans. Mitochondrion 11:303-7.
Kristiansen 2011 J Biol Chem 2011 Kristiansen G, Hu J, Wichmann D, Stiehl DP, Rose M, Gerhardt J, Bohnert A, ten Haaf A, Moch H, Raleigh J, Varia MA, Subarsky P, Scandurra FM, Gnaiger E, Gleixner E, Bicker A, Gassmann M, Hankeln T, Dahl E, Gorr TA (2011) Endogenous myoglobin in breast cancer is hypoxia-inducible by alternate transcription and functions to impair mitochondrial activity: a role in tumor suppression? J Biol Chem 286:43417-28.
Eberhart 2011 Biochim Biophys Acta 2011 Eberhart K, Rainer J, Bindreither D, Ritter I, Gnaiger E, Kofler R, Oefner PJ, Renner K (2011) Glucocorticoid-induced alterations in mitochondrial membrane properties and respiration in childhood acute lymphoblastic leukemia. Biochim Biophys Acta 1807:719-25.
Sjoevall 2010 Crit Care 2010 Sjoevall F, Morota S, Hansson Magnus J, Friberg H, Gnaiger E, Elmer E (2010) Temporal increase of platelet mitochondrial respiration is negatively associated with clinical outcome in patients with sepsis. Crit Care 14:R214.
Scandurra 2010 Adv Exp Med Biol 2010 Scandurra FM, Gnaiger E (2010) Cell respiration under hypoxia: facts and artefacts in mitochondrial oxygen kinetics. Adv Exp Med Biol 662:7-25.
Renner-Sattler 2010 Mitochondr Physiol Network MiP2010 2010
MiPsociety
Renner-Sattler K, Gnaiger E, eds (2010) Mitochondrial physiology. The many functions of the organism in our cells. Mitochondr Physiol Network 15.6:128 pp. ISBN 978-3-9502399-4-2
Kozlov 2010 Inflammation 2010 Kozlov AV, van Griensven M, Haindl S, Kehrer I, Duvigneau JC, Hartl RT, Ebel T, Jafarmadar M, Calzia E, Gnaiger E, Redl H, Radermacher P, Bahrami Sl (2010) Peritoneal inflammation in pigs is associated with early mitochondrial dysfunction in liver and kidney. Inflammation 33:295-305.
Smolkova 2010 J Bioenerg Biomembr 2010 Smolková K, Bellance N, Scandurra F, Génot E, Gnaiger E, Plecitá-Hlavatá L, Ježek P, Rossignol R (2010) Mitochondrial bioenergetic adaptations of breast cancer cells to aglycemia and hypoxia. J Bioenerg Biomembr 42:55-67.
Sommer 2010 Eur Respir J 2010 Sommer N, Pak O, Schörner S, Derfuss T, Krug A, Gnaiger E, Ghofrani HA, Schermuly RT, Huckstorf C, Seeger W, Grimminger F, Weissmann N (2010) Mitochondrial cytochrome redox states and respiration in acute pulmonary oxygen sensing. Eur Respir J 36:1056-66.
Aguirre 2010 Biochim Biophys Acta 2010 Aguirre E, Rodríguez-Juárez F, Bellelli A, Gnaiger E, Cadenas S (2010) Kinetic model of the inhibition of respiration by endogenous nitric oxide in intact cells. Biochim Biophys Acta 1797:557-65.
Gnaiger 2009 OCESHS 2009 Gnaiger E (2009) Open and closed systems: Styles of thinking explain controversies on the 'Negative Entropy' concept of Ludwig Boltzmann and Erwin Schrödinger. Third ICESHS, Austrian Academy of Sciences, Vienna 2008.
Gnaiger 2009 Int J Biochem Cell Biol 2009 Gnaiger E (2009) Capacity of oxidative phosphorylation in human skeletal muscle. New perspectives of mitochondrial physiology. Int J Biochem Cell Biol 41:1837-45.
Rostrup M 2008 Amino Acids 2008 Rostrup M, Fossbakk A, Hauge A, Kleppe R, Gnaiger E, Haavik J (2008) Oxygen dependence of tyrosine hydroxylase. Amino Acids 34:455-64.
Gnaiger 2008 POS 2008
O2k-Protocols contents
Gnaiger E (2008) Polarographic oxygen sensors, the oxygraph and high-resolution respirometry to assess mitochondrial function. In: Mitochondrial Dysfunction in Drug-Induced Toxicity (Dykens JA, Will Y, eds) John Wiley & Sons, Inc, Hoboken, NJ:327-52.
Schneeberger 2008 Shock 2008 Schneeberger S, Kuznetsov AV, Seiler R, Renz O, Meusburger H, Mark W, Brandacher G, Margreiter R, Gnaiger E (2008) Mitochondrial ischemia-reperfusion injury of the transplanted rat heart: improved protection by preservation versus cardioplegic solutions. Shock 30:365-71.
Aragones 2008 Nat Genet 2008 Aragonés J, Schneider M, Van Geyte K, Fraisl P, Dresselaers T, Mazzone M, Dirkx R, Zacchigna S, Lemieux H, Jeoung NH, Lambrechts D, Bishop T, Lafuste P, Diez-Juan A, K Harten S, Van Noten P, De Bock K, Willam C, Tjwa M, Grosfeld A, Navet R, Moons L, Vandendriessche T, Deroose C, Wijeyekoon B, Nuyts J, Jordan B, Silasi-Mansat R, Lupu F, Dewerchin M, Pugh C, Salmon P, Mortelmans L, Gallez B, Gorus F, Buyse J, Sluse F, Harris RA, Gnaiger E, Hespel P, Van Hecke P, Schuit F, Van Veldhoven P, Ratcliffe P, Baes M, Maxwell P, Carmeliet P (2008) Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism. Nat Genet 40:170-80.
Boushel 2007 Diabetologia 2007 Boushel RC, Gnaiger E, Schjerling P, Skovbro M, Kraunsoee R, Dela F (2007) Patients with Type 2 diabetes have normal mitochondrial function in skeletal muscle. Diabetologia 50:790-6.
Gnaiger 2007 MitoPathways 2007
O2k-Protocols
Gnaiger E ed (2007) Mitochondrial Pathways and Respiratory Control. OROBOROS MiPNet Publications, Innsbruck:96 pp. Electronic 1st ed ISBN 978-3-9502399-0-4 (see 4th edition: Gnaiger 2014 MitoPathways).
Stadlmann 2006 Cell Biochem Biophys 2006 Stadlmann S, Renner K, Pollheimer J, Moser PL, Zeimet AG, Offner FA, Gnaiger E (2006) Preserved coupling of oxydative phosphorylation but decreased mitochondrial respiratory capacity in IL-1ß treated human peritoneal mesothelial cells. Cell Biochem Biophys 44:179-86.
Cadenas 2006 Biochim Biophys Acta 2006 Aguirre E, Rodriguez-Juarez F, Gnaiger E, Cadenas S (2006) Measurement of the control of cellular respiration by nitric oxide under normoxia and hypoxia: instrumental comparison including high-resolution respirometry. Biochim Biophys Acta, EBEC Short Reports Suppl 14:136-7.
Huetter 2006 Exp Gerontol 2006 Hütter E, Unterluggauer H, Garedew A, Jansen-Dürr P, Gnaiger E (2006) High-resolution respirometry - a modern tool in aging research. Exp Gerontol 41:103-9.
Garedew 2005 Eur Shock Soc 2005 Garedew A, Hütter E, Haffner B, Gradl P, Gradl L, Jansen-Dürr P, Gnaiger E (2005) High-resolution respirometry for the study of mitochondrial function in health and disease. The OROBOROS O2k. Proc 11th Congress Eur Shock Soc, Vienna, Austria (Redl H, ed) Medimond, Bologna:107-11.
Gnaiger 2005 Mitochondr Physiol Network MiP2005 2005
MiPsociety
Gnaiger E, ed (2005) Mitochondrial physiology. The many faces and functions of an organelle. MiP2005 Abstracts. Mitochondr Physiol Network 10.09:1-152.
Huetter 2004 Biochem J 2004 Hütter E, Renner K, Pfister G, Stöckl P, Jansen-Dürr P, Gnaiger E (2004) Senescence-associated changes in respiration and oxidative phosphorylation in primary human fibroblasts. Biochem J 380:919-28.
Kuznetsov 2004 Am J Physiol Heart Circ Physiol 2004 Kuznetsov AV, Schneeberger S, Seiler R, Brandacher G, Mark W, Steurer W, Saks V, Usson Y, Margreiter R, Gnaiger E (2004) Mitochondrial defects and heterogeneous cytochrome c release after cardiac cold ischemia and reperfusion. Am J Physiol Heart Circ Physiol 286:H1633–41.
Pecina 2004 Am J Physiol Cell Physiol 2004 Pecina P, Gnaiger E, Zeman J, Pronicka E, Houstek J (2004) Decreased affinity to oxygen of cytochrome c oxidase in Leigh syndrome caused by SURF1 mutations. Am J Physiol Cell Physiol 287:C1384-8.
MiPNet08.10 MiP2003 2003
MiPsociety
Gnaiger E, Renner K, eds (2003) 3rd Conference on Mitochondrial Physiology. Schröcken, Austria, Sept 2003. Programme and Abstracts. Mitochondr Physiol Network 08.10:1-38.
Renner 2003 Biochim Biophys Acta 2003 Renner K, Amberger A, Konwalinka G, Gnaiger E (2003) Changes of mitochondrial respiration, mitochondrial content and cell size after induction of apoptosis in leukemia cells. Biochim Biophys Acta 1642:115-23.
Gnaiger 2003 Mitochondr Physiol Network MiP2003 2003
MiPsociety
Gnaiger E, Renner K, eds (2003) 3rd Conference on Mitochondrial Physiology. Schröcken, Austria, Sept 2003. Programme and Abstracts. Mitochondr Physiol Network 08.10:1-38.
Gnaiger 2003 Adv Exp Med Biol 2003 Gnaiger E (2003) Oxygen conformance of cellular respiration. A perspective of mitochondrial physiology. Adv Exp Med Biol 543:39-55.
Gnaiger 2002 Biochem Soc Trans 2002 Gnaiger E, Kuznetsov AV (2002) Mitochondrial respiration at low levels of oxygen and cytochrome c. Biochem Soc Trans 30:242-8.
Huetter 2002 Mol Biol Rep 2002 Hütter E, Renner K, Jansen-Dürr P, Gnaiger E (2002) Biphasic oxygen kinetics of cellular respiration and linear oxygen dependence of antimycin A inhibited oxygen consumption. Mol Biol Rep 29:83-7.
Kuznetsov 2002 Anal Biochem 2002 Kuznetsov AV, Strobl D, Ruttmann E, Königsrainer A, Margreiter R, Gnaiger E (2002) Evaluation of mitochondrial respiratory function in small biopsies of liver. Anal Biochem 305:186-94.
Renner 2002 Mol Biol Rep 2002 Renner K, Kofler R, Gnaiger E (2002) Mitochondrial function in glucocorticoid triggered T-ALL cells with transgenic Bcl-2 expression. Mol Biol Rep 29:97-101.
Steininger 2002 J Antimicrob Chemother 2002 Steininger C, Allerberger F, Gnaiger E (2002) Clinical significance of inhibition kinetics in Streptococcus pyogenes in response to penicillin. J Antimicrob Chemother 50:517-23.
Stadlmann 2002 Transplantation 2002 Stadlmann S, Rieger G, Amberger A, Kuznetsov AV, Margreiter R, Gnaiger E (2002) H2O2-mediated oxidative stress versus cold ischemia-reperfusion: mitochondrial respiratory defects in cultured human endothelial cells. Transplantation 74:1800-3.
Gnaiger 2001 Respir Physiol 2001 Gnaiger E (2001) Bioenergetics at low oxygen: dependence of respiration and phosphorylation on oxygen and adenosine diphosphate supply. Respir Physiol 128:277-97.
Gnaiger 2000 Transpl Int 2000 Gnaiger E, Kuznetsov AV, Rieger G, Amberger A, Fuchs A, Stadlmann S, Eberl T, Margreiter R (2000) Mitochondrial defects by intracellular calcium overload versus endothelial cold ischemia/reperfusion injury. Transpl Int 13:555-7.
Gnaiger 2000 Life in the Cold 2000
O2k-Protocols contents
Gnaiger E, Kuznetsov AV, Schneeberger S, Seiler R, Brandacher G, Steurer W, Margreiter R (2000) Mitochondria in the cold. In: Life in the Cold (Heldmaier G, Klingenspor M, eds) Springer, Heidelberg, Berlin, New York:431-42.
Gnaiger 2000 Proc Natl Acad Sci U S A 2000 Gnaiger E, Méndez G, Hand SC (2000) High phosphorylation efficiency and depression of uncoupled respiration in mitochondria under hypoxia. Proc Natl Acad Sci U S A 97:11080-5.
Kuznetsov 2000 Transplant Proc 2000 Kuznetsov AV, Brandacher G, Steurer W, Margreiter R, Gnaiger E (2000) Isolated rat heart mitochondria and whole heart as models for mitochondrial cold ischemia-reperfusion injury. Transplant Proc 32:45.
Gnaiger 2000 Transplant Proc 2000 Gnaiger E, Kuznetsov AV, Königsrainer A, Margreiter R (2000) Autooxidation of glutathione in organ preservation solutions. Transplant Proc 32:14.
Oexle 1999 Biochim Biophys Acta 1999 Oexle H, Gnaiger E, Weiss G (1999) Iron-dependent changes in cellular energy metabolism: influence on citric acid cycle and oxidative phosphorylation. Biochim Biophys Acta 1413:99-107.
Steurer 1999 Transplant Proc 1999 Steurer W, Stadlmann S, Roberts K, Fischer M, Margreiter R, Gnaiger E (1999) Quality assessment of isolated pancreatic rat islets by high-resolution respirometry. Transplant Proc 31:650.
Stadlmann 1999 Transplant Proc 1999 Stadlmann S, Amberger A, Kuznetsov AV, Rieger G, Hengster P, Margreiter R, Gnaiger E (1999) Does H2O2-mediated oxidative stress reproduce mitochondrial cold preservation/reoxygenation injury in endothelial cells? Transplant Proc 31:993.
Gnaiger 1999 Transplant Proc 1999 Gnaiger E, Rieger G, Stadlmann S, Amberger A, Eberl T, Margreiter R (1999) Mitochondrial defect in endothelial cold ischemia/reperfusion injury. Transplant Proc 31:994-5.
Kuznetsov 1999 Transplant Proc 1999 Kuznetsov AV, Brandacher G, Steurer W, Margreiter R, Gnaiger E (1999) Estimation of mitochondrial damage in heart preservation. Transplant Proc 31:992.
Gnaiger 1998 J Exp Biol 1998 Gnaiger E, Lassnig B, Kuznetsov AV, Rieger G, Margreiter R (1998) Mitochondrial oxygen affinity, respiratory flux control, and excess capacity of cytochrome c oxidase. J Exp Biol 201:1129-39.
Kuznetsov 1998 BTK 1998 Kuznetsov AV, Lassnig B, Margreiter R, Gnaiger E (1998) Diffusion limitation of oxygen versus ADP in permeabilized muscle fibers. In BioThermoKinetics in the Post Genomic Era (Larsson C, Påhlman I-L, Gustafsson L, eds) Chalmers Reproservice, Göteborg:273-6.
Lassnig 1998 BTK 1998 Lassnig B, Kuznetsov AV, Margreiter R, Gnaiger E (1998) Aerobic-anoxic transitions and regulation of mitochondrial oxygen flux. In BioThermoKinetics in the Post Genomic Era (Larsson C, Påhlman I-L, Gustafsson L, eds) Chalmers Reproservice, Göteborg:312-6.
Gnaiger 1998 BTK-HRR 1998 Gnaiger E, Kuznetsov AV, Lassnig B, Fuchs A, Reck M, Renner K, Stadlmann S, Rieger G, Margreiter R (1998) High-resolution respirometry. Optimum permeabilization of the cell membrane by digitonin. In BioThermoKinetics in the Post Genomic Era (Larsson C, Pahlman I-L, Gustafsson L, eds) Chalmers Reproservice, Göteborg:89-95.
Gnaiger 1998 BTK-COX 1998 Gnaiger E, Kuznetsov AV, Lassnig B, Margreiter R (1998) Functional interpretation of the flux control coefficient and excess capacity of cytochrome c oxidase at intracellular oxygen. In BioThermo-Kinetics in the Post Genomic Era (Larsson C, Påhlman I-L, Gustafsson L, eds) Chalmers Reproservice, Göteborg:81-8.
Gnaiger 1998 Biochim Biophys Acta 1998 Gnaiger E, Lassnig B, Kuznetsov AV, Margreiter R (1998) Mitochondrial respiration in the low oxygen environment of the cell: Effect of ADP on oxygen kinetics. Biochim Biophys Acta 1365:249-54.
Gnaiger 1997 Transplant Proc 1997 Gnaiger E, Rieger G, Kuznetsov A, Fuchs A, Stadlmann S, Lassnig B, Hengster P, Eberl T, Margreiter R (1997) Mitochondrial ischemia-reoxygenation injury and plasma membrane integrity in human endothelial cells. Transplant Proc 29:3524-6.
Sperl 1997 Mol Cell Biochem 1997 Sperl W, Skladal D, Gnaiger E, Wyss M, Mayr U, Hager J, Gellerich FN (1997) High resolution respirometry of premeabilized skeletal muscle fibers in the diagnosis of neuromuscular disorders. Mol Cell Biochem 174:71-8.
Steinlechner-Maran 1997 Transplantation 1997 Steinlechner-Maran R, Eberl T, Kunc M, Schröcksnadel H, Margreiter R, Gnaiger E (1997) Respiratory defect as an early event in preservation/reoxygenation injury in endothelial cells. Transplantation 63:136-42.
Gnaiger 1996 BTK-441 1996 Gnaiger E, Reck M, Steinlechner-Maran R, Rieger G, Stadlmann S, Margreiter R (1996) High resolution - the decisive difference in mitochondrial and cellular respirometry. In BioThermoKinetics of the Living Cell (Westerhoff HV, Snoep JL, Wijker JE, Sluse FE, Kholodenko BN, eds), BioThermo-Kinetics, Amsterdam:441-2.
Steinlechner-Maran 1996 Am J Physiol Cell Physiol 1996 Steinlechner-Maran R, Eberl T, Kunc M, Margreiter R, Gnaiger E (1996) Oxygen dependence of respiration in coupled and uncoupled endothelial cells. Am J Physiol Cell Physiol 271:C2053-61.
Gellerich 1995 HRR 1995 Gellerich FN, Skladal D, Schranzhofer R, Lanznaster N, Kunz WS, Wisniewski E, Kuznetsov A, Krishmer M, Gnaiger E, Margreiter R, Sperl W (1995) Hochauflösende Respirometrie und multiple Substrat/Inhibitor-Titration zum funktionellen Nachweis mitochondrialer Defekte in permeabilisierten Muskelfasern. In: Molekulare Grundlage hereditärer Myopathien. (Gross M, Gresser U, Hrsg), Zuckschwerdt Verlag, München, Bern, Wien, New York:52-66.
Gnaiger 1995 J Bioenerg Biomembr 1995 Gnaiger E, Steinlechner-Maran R, Méndez G, Eberl T, Margreiter R (1995) Control of mitochondrial and cellular respiration by oxygen. J Bioenerg Biomembr 27:583-96.
Kemp 1994 BTK-226 1994
BTK1994
Kemp RB, Hoare S, Schmalfeldt M, Bridge ChMC, Evansa PM, Gnaiger E (1994) A thermochemical study of the producion of lactate by glutaminolysis and glycolysis in mouse macrophage hybridoma cells. In: What is Controlling Life? (Gnaiger E, Gellerich FN, Wyss M, eds) Modern Trends in BioThermoKinetics 3. Innsbruck Univ Press:226-31.
Gellerich 1994 BTK-263 1994
BTK1994
Gellerich FN, Steinlechner R, Wyss M, Eberl T, Müller LC, Skladal D, Sperl W, Dapunt O, Margreiter R, Gnaiger E (1994) Mitochondrial function in the atrial appendage of the human heart. Characterization by high-resolution respirometry. In: What is Controlling Life? (Gnaiger E, Gellerich FN, Wyss M, eds) Modern Trends in BioThermo-Kinetics 3. Innsbruck Univ Press:263-7.
Skladal 1994 BTK-268 1994
BTK1994
Skladal D, Sperl W, Schranzhofer R, Krismer M, Gnaiger E, Margreiter R, Gellerich FN (1994) Preservation of mitochondrial functions in human skeletal muscle during storage in high energy preservation solution (HEPS). In: What is Controlling Life? (Gnaiger E, Gellerich FN, Wyss M, eds) Modern Trends in BioThermoKinetics 3. Innsbruck Univ Press:268-71.
Gnaiger 1994 BTK 1994
BTK1994
Gnaiger E, Gellerich FN, Wyss M (1994) What is controlling life? 50 years after Erwin Schrödinger's What is life? Modern trends in BiothermoKinetics 3, Innsbruck Univ Press:336 pp.
Sperl 1994 J Inher Metab Dis 1994 Sperl W, Skladal D, Lanznaster N, Schranzhofer R, Zaunschirm G, Gnaiger E, Gellerich FN (1994) Polarographic studies of saponin-skinned muscle fibers in patients with mitochondrial myopathies. J Inher Metab Dis 17:307-10.
Haller 1994 Anal Biochem 1994 Haller T, Ortner M, Gnaiger E (1994) A respirometer for investigating oxidative cell metabolism. Toward optimization of respiratory studies. Anal Biochem 218:338-42.
SteinlechnerMaran 1994 BTK-283 1994
BTK1994
Steinlechner-Maran R, Eberl T, Margreiter R, Gnaiger E (1994) Oxygen dependence of cellular respiration in endothelial cells: A sensitive toxicological test. In: What is Controlling Life? (Gnaiger E, Gellerich FN, Wyss M, eds) Modern Trends in BioThermo-Kinetics 3. Innsbruck Univ Press:283-7.
Knoblechner 1994 BTK-294 1994
BTK1994
Knoblechner A, Steinlechner R, Schirmer M, Gellerich FN, Margreiter R, Konwalinka G, Gnaiger E (1994) The effect of 2-chlorodeoxy-adenosine on endogenous respiration of a human lymphoma cell line (U-937). In: What is Controlling Life? (Gnaiger E, Gellerich FN, Wyss M, eds) Modern Trends in BioThermoKinetics 3. Innsbruck Univ Press:294-6.
Eberl 1994 BTK-288 1994
BTK1994
Eberl T, Steinlechner R, Salvenmoser W, Abendstein B, Rhomberg M, Schröcksnadel H, Schmid T, Gnaiger E, Margreiter R (1994) Endothelial cell cultures as a model for organ preservation studies. In: What is Controlling Life? (Gnaiger E, Gellerich FN, Wyss M, eds) Modern Trends in BioThermoKinetics 3. Innsbruck Univ Press:288-93.
Laterveer 1994 BTK-186 1994
BTK1994
Laterveer FD, Gellerich FN, Gnaiger E, Nicolay K (1994) Macromolecules increase the channeling of ADP from mitochondrially associated hexokinase to the mitochondrial matrix. In: What is Controlling Life? (Gnaiger E, Gellerich FN, Wyss M, eds) Modern Trends in BioThermoKinetics 3. Innsbruck Univ Press:186-90.
Gnaiger 1994 BTK-62 1994
BTK1994
Gnaiger E (1994) Negative entropy for living systems: controversy between Nobel Laureates Schrödinger, Pauling and Perutz. In: What is Controlling Life? (Gnaiger E, Gellerich FN, Wyss M, eds) Modern Trends in BioThermoKinetics 3. Innsbruck Univ Press: 62-70.
Gellerich 1994 BTK-181 1994
BTK1994
Gellerich FN, Laterveer FD, Gnaiger E, Nicolay K (1994) Effect of macromolecules on ADP-transport into mitochondria. In: What is Controlling Life? (Gnaiger E, Gellerich FN, Wyss M, eds) Modern Trends in BioThermoKinetics 3. Innsbruck Univ Press:181-5.
Mendez 1994 BTK-191 1994
BTK1994
Méndez G, Gnaiger E (1994) How does oxygen pressure control oxygen flux in isolated mitochondria? A methodological approach by high-resolution respirometry and digital data analysis. In: What is Controlling Life? (Gnaiger E, Gellerich FN, Wyss M, eds) Modern Trends in BioThermo-Kinetics 3. Innsbruck Univ Press:191-4.
Gnaiger 1994 BTK-207 1994
BTK1994
Gnaiger E, Wyss M (1994) Chemical forces in the cell: Calculation for the ATP system. In: What is Controlling Life? (Gnaiger E, Gellerich FN, Wyss M, eds) Modern Trends in BioThermoKinetics 3. Innsbruck Univ Press:207-12.
Doeller 1993 J Exp Zool 1993 Doeller JE, Kraus DW, Shick JM, Gnaiger E (1993) Heat flux, oxygen flux and mitochondrial redox state as a function of oxygen availability and ciliary beat activity in isolated gills of Mytilus edulis. J Exp Zool 265:1-8.
Gnaiger 1993 Verh Dtsch Zool Ges 1993 Gnaiger E (1993) Adaptations to winter hypoxia in a shallow alpine lake. Ecophysiological energetics of Cyclops abyssorum and rainbow trout. Verh Dtsch Zool Ges 86:43-65.
Von Stockar 1993 Biochim Biophys Acta 1993 Von Stockar U, Gustafsson L, Larsson C, Marison I, Tissot P, Gnaiger E (1993) Thermodynamic considerations in constructing energy balances for cellular growth. Biochim Biophys Acta 1183:221-40.
Gnaiger 1993 Hypoxia 1993 Gnaiger E (1993) Efficiency and power strategies under hypoxia. Is low efficiency at high glycolytic ATP production a paradox? In: Surviving Hypoxia: Mechanisms of Control and Adaptation. Hochachka PW, Lutz PL, Sick T, Rosenthal M, Van den Thillart G (eds) CRC Press, Boca Raton, Ann Arbor, London, Tokyo:77-109.
Buck 1993 Am J Physiol Regul Integr Comp Physiol 1993 Buck LT, Hochachka PW, Schön A, Gnaiger E (1993) Microcalorimetric measurement of reversible metabolic suppression induced by anoxia in isolated hepatocytes. Am J Physiol Regul Integr Comp Physiol 265:R1014-9.
Gnaiger 1993 Pure Appl Chem 1993 Gnaiger E (1993) Nonequilibrium thermodynamics of energy transformations. Pure Appl Chem 65:1983-2002.
Gnaiger 1993 Transitions 1993 Gnaiger E (1993) Homeostatic and microxic regulation of respiration in transitions to anaerobic metabolism. In: The vertebrate gas transport cascade: Adaptations to environment and mode of life. Bicudo JEPW (ed), CRC Press, Boca Raton, Ann Arbor, London, Tokyo:358-70.
Gnaiger 1992 Funct Ecol 1992 Gnaiger E (1992) Optimum efficiency of energy transformation and the evolution of catabolic pathways. Funct Ecol 6:234-41.
Gnaiger 1991 Soc Exp Biol Seminar Series 1991 Gnaiger E (1991) Animal energetics at very low oxygen: Information from calorimetry and respirometry. In: Strategies for gas exchange and metabolism. Woakes R, Grieshaber M, Bridges CR (eds), Soc Exp Biol Seminar Series 44, Cambridge Univ Press, London:149-71.
Haller 1990 CYCLOBIOS Kinetics 1990 Haller T, Gnaiger E (1990) Kinetic control and reaction pressure in steady state coupled mitochondria. CYCLOBIOS Newsletter 4:63-6.
Raich 1990 CYCLOBIOS 1990 Raich K, Haller T, Gnaiger E (1990) The kinetics of mitochondria isolated from oligochaetes: Comparison with classical rat liver mitochondria. CYCLOBIOS Newsletter 4:77-9.
Schoen 1990 Cyclobios 1990 Schön A, Haller T, Gnaiger E (1990) Hexokinase induced, steady state coupled mitochondria studied by injection calorimetry and respirometry. CYCLOBIOS Newsletter 4:67-72.
Gnaiger 1990 Biochim Biophys Acta 1990 Gnaiger E, Kemp RB (1990) Anaerobic metabolism in aerobic mammalian cells: information from the ratio of calorimetric heat flux and respirometric oxygen flux. Biochim Biophys Acta 1016:328-32.
Doeller 1990 Thermochim Acta 1990 Doeller JE, Kraus DW, Gnaiger E, Shick JM (1990) Calorespirometry and spectrophotometry of the ciliated gill of the marine mussel Mytilus edulis. Thermochim Acta 172:171-8.
Gnaiger 1990 CYCLOBIOS 1990 Gnaiger E, Steinlechner R, Doeller JE, Haller T, eds (1990) Calorimetry, Respirometry and Mitochondrial Energetics. CYCLOBIOS Newsletter 4:93 pp.
Hand 1989 Thieme 1989 Hand SC, Gnaiger E (1989) Metabolic arrest in Artemia embryos quantified with microcalorimetric, respirometric and biochemical measurements. In: Energy transformations in cells and organisms. Wieser W, Gnaiger E (eds), Thieme, Stuttgart:155-62.
Gnaiger 1989 Energy Transformation 1989 Gnaiger E (1989) Mitochondrial respiratory control: energetics, kinetics and efficiency. In: Energy transformations in cells and organisms. Wieser W, Gnaiger E (eds), Thieme, Stuttgart:6-17.
Gnaiger 1989 Soc Exp Biol Seminar Series 1989 Gnaiger E, Shick JM, Widdows J (1989) Metabolic microcalorimetry and respirometry of aquatic animals. In: Techniques in comparative respiratory physiology. An experimental approach. Bridges CR, Butler PJ (eds), Soc Exp Biol Seminar Series, Cambridge Univ Press, London:113-35.
Hand 1988 Science 1988 Hand SC, Gnaiger E (1988) Anaerobic dormancy quantified in Artemia embryos: A calorimetric test of the control mechanism. Science 239:1425-7.
Gnaiger 1987 Hydrobiol 1987 Gnaiger E, Kaufmann R, Staudigl I (1987) Physiological reactions of aquatic oligochaetes to environmental anoxia. Hydrobiol 155:155.
Gnaiger 1987 Physiol Zool 1987 Gnaiger E, Staudigl I (1987) Aerobic metabolism and physiological responses of aquatic oligochaetes to environmental anoxia. Heat dissipation, oxygen consumption, feeding and defecation. Physiol Zool 60:659-77.
Putzer 1985 Comp Biochem Physiol 1985 Putzer V, Gnaiger E, Lackner R (1985) Flexibility of anaerobic metabolism in aquatic oligochaetes (Tubifex sp.). Biochemical and calorimetric changes induced by a deproteinized hydrolysate of bovine blood. Comp Biochem Physiol 82A:965-70.
Gnaiger 1984 Oecologia 1984 Gnaiger E, Bitterlich G (1984) Proximate biochemical proposition and caloric content calculated from elemental CHN analysis: a stoichiometric concept. Oecologia 62:289-98.
Gnaiger 1983 Springer POS 1983 Gnaiger E, Forstner H, eds (1983) Polarographic Oxygen Sensors. Aquatic and Physiological Applications. Springer, Berlin, Heidelberg, New York:370 pp.
Gnaiger 1983 J Exp Zool 1983 Gnaiger E (1983) Heat dissipation and energetic efficiency in animal anoxibiosis. Economy contra power. J Exp Zool 228:471-90.
Gnaiger 1983 POS 1983 Gnaiger E, Forstner H, eds (1983) Polarographic oxygen sensors. Aquatic and physiological applications. Springer, Berlin, Heidelberg, New York:370 pp.
Forstner 1983 POS 1983 Forstner H, Gnaiger E (1983) Calculation of equilibrium oxygen concentration. In: Polarographic Oxygen Sensors. Aquatic and Physiological Applications. Gnaiger E, Forstner H (eds), Springer, Berlin, Heidelberg, New York:321-33.
Gnaiger 1983 Sci Tools 1983 Gnaiger E (1983) Microcalorimetric monitoring of biological activities: Ecological and toxicological studies with aquatic animals. Sci Tools 30:21-6.
Gnaiger 1983 POS-in situ 1983 Gnaiger E (1983) In situ measurement of oxygen profiles in lakes: microstratifications, oscillations, and the limits of comparison with chemical methods. In: Polarographic Oxygen Sensors. Aquatic and Physiological Applications. Gnaiger E, Forstner H (eds), Springer, Berlin, Heidelberg, New York:245-64.
Gnaiger 1983 POS-EnergEquivalents 1983 Gnaiger E (1983) Calculation of energetic and biochemical equivalents of respiratory oxygen consumption. In: Polarographic Oxygen Sensors. Aquatic and Physiological Applications. Gnaiger E, Forstner H (eds), Springer, Berlin, Heidelberg, New York:337-45.
Hitchman 1983 POS Membrane 1983 Hitchman ML, Gnaiger E (1983) A thermodynamic consideration of permeability coefficients of membranes. In: Polarographic Oxygen Sensors. Aquatic and Physiological Applications. Gnaiger E, Forstner H (eds), Springer, Berlin, Heidelberg, New York:31-6.
Gnaiger 1983 POS symbols 1983 Gnaiger E (1983) Symbols and units: toward standardization. In: Polarographic Oxygen Sensors. Aquatic and Physiological Applications. Gnaiger E, Forstner H (eds), Springer, Berlin, Heidelberg, New York:352-8.
Gnaiger 1983 POS-pO2 1983 Gnaiger E (1983) Calculation of pO2 in water equilibrated with a mixture of room air and nitrogen. In: Polarographic Oxygen Sensors. Aquatic and Physiological Applications. Gnaiger E, Forstner H (eds), Springer, Berlin, Heidelberg, New York:334-6.
Gnaiger 1983 POS preface 1983 Gnaiger E(1983) Preface: A biologist´s view. In: Polarographic Oxygen Sensors. Aquatic and Physiological Applications. Gnaiger E, Forstner H (eds), Springer, Berlin, Heidelberg, New York:V-VII.
Gnaiger 1983 Aquat Physiol Appl 1983 Gnaiger E (1983) The twin-flow microrespirometer and simultaneous calorimetry. In: Polarographic Oxygen Sensors. Aquatic and Physiological Applications. Gnaiger E, Forstner H (eds), Springer, Berlin, Heidelberg, New York:134-66.
Gnaiger 1980 FEBS Lett 1980 Gnaiger E (1980) Energetics of invertebrate anoxibiosis: direct calorimetry in aquatic oligochaetes. FEBS Lett 112:239-42.
Gnaiger 1978 Limnol Oceanogr 1978 Gnaiger E, Gluth G, Wieser W (1978) pH fluctuation in an intertidal beach in Bermuda. Limnol Oceanogr 23:851-7.
Gnaiger 1977 Invertrebrate anoxibiosis 1977 Gnaiger E (1977) Thermodynamic considerations of invertebrate anoxibiosis. In: Applications of calorimetry in life sciences. Lamprecht I, Schaarschmidt B (eds), de Gruyter, Berlin:281-303.
Wieser 1974 Mar Biol 1974 Wieser W, Ott J, Schiemer F, Gnaiger E (1974) An ecophysiological study of some meiofauna species inhabiting a sandy beach at Bermuda. Mar Biol 26:235-48.


Abstracts

Published Reference
Krumschnabel 2016a Abstract MitoFit Science Camp 2016 2016 O2k-Protocols: Mitochondrial preparations for HRR.
Sumbalova 2016b Abstract MitoFit Science Camp 2016 2016 Human blood cells: isolation and HRR.
Burtscher J 2016 Abstract MitoFit Science Camp 2016 2016 Oxidative phosphorylation in the healthy and epileptic mouse brain.
Doerrier 2016 Abstract MitoFit Science Camp 2016 2016 Development of a SUIT reference protocol for OXPHOS analysis by high-resolution respirometry.
Sumbalova 2016a Abstract MitoFit Science Camp 2016 2016 Optimizing strategies on the malate concentration in SUIT protocols.
Laner 2016 Abstract MitoFit Science Camp 2016 2016 OXPHOS and ETS capacity in permeabilized fibres of canine superathletes. Analysis of HRR data presenting unexpected challenges.
Hoppel 2016b Abstract MitoFit Science Camp 2016 2016 Comparison of permeabilized skeletal muscle fibers or isolated mitochondria for the detection of oxidative phosphorylation defects.
Gnaiger 2016 Abstract EBEC Riva del Garda 2016 2016 MitoFit and MITOEAGLE – towards a global data bank on mitochondrial physiology.
Gnaiger 2016 Abstract SFRR Australasia 2016 2016 Facts and artefacts in measurements of H2O2 production under hypoxia.
Krumschnabel 2016b Abstract MitoFit Science Camp 2016 2016 O2k-MultiSensor: Mitochondrial respiration media for HRR and simultaneous O2k-Fluorometry.
Volani 2016 Abstract MitoFit Science Camp 2016 2016 Effects of iron imbalances on mitochondrial activity in mouse liver homogenate and permabilized rat PBMCs.
Schoepf 2016 Abstract Androgens 2016 2016 Mitochondrial function and mitochondrial heteroplasmy levels differ between benign and malignant prostate tissue
Gnaiger 2016 Abstract UMDF2016 2016 Schöpf B, Schäfer G, Weber A, Talasz H, Eder IE, Klocker H, Gnaiger E (2016) Oxidative phosphorylation and mitochondrial function differ between human prostate tissue and cultured cells.
Bezuidenhout 2016a Abstract MitoFit Science Camp 2016 2016 Comparison of oxygen dependence of respiration in permeabilized mouse skeletal muscle fibers in two respiration media, MiR06Cr and Buffer Z containing Ctl, Cr and Blebbistatin.
Lamberti 2016 Abstract MitoFit Science Camp 2016 2016 Development of a reference sample for HRR.
Bezuidenhout 2016b Abstract MitoFit Science Camp 2016 2016 Analysis and comparison of mitochondrial function using cooling plate or ice during mechanical separation of mouse skeletal muscle fibers.
Chicco 2016b Abstract MitoFit Science Camp 2016 2016 OXPHOS coupling efficiency of permeabilized muscle fibers predicts metabolic efficiency of subjects exercising at 5260 m.
Hoppel 2015 Abstract MiP2015 2015 Effects of ultramarathon performance on mitochondrial respiration in human platelets.
Laner 2015 Abstract MiP2015 2015 Comparative mitochondrial physiology: OXPHOS and ETS capacity in permeabilized fibres of canine superathletes.
Laner 2015 Abstract MiPschool Greenville 2015 2015 Comparative mitochondrial physiology: OXPHOS and ETS capacity in permeabilized fibres of canine superathletes.
Volani 2015 Abstract IOC106 2015 Volani C, Haschka D, Demetz E, Doerrier C, Gnaiger E, Weiss G (2015) Determination of mitochondrial respiration in peripheral blood mononuclear cells. Mitochondr Physiol Network 20.10.
Laner 2015 Abstract MiPschool Cape Town 2015 2015 The OROBOROS Oxygraph-2k for high-resolution respirometry and O2k-Fluorometry: a new quality in OXPHOS analysis.
Gnaiger 2015 Abstract DrugDiscovery conference 2015 2015 A lifestyle drug for mitochondrial fitness – from respiratory mitochondrial diagnosis to therapy.
Gnaiger 2015 Abstract MiPschool Cape Town 2015 2015 The functional design of the electron transfer system: substrate control of mitochondrial respiration.
Gnaiger 2015 Abstract MiPschool Cape Town 2015 II 2015 On coupling control of mitochondrial respiration. What is wrong with the RCR?
Doerrier 2015 Abstract MiPschool Greenville 2015 2015 "Succinate paradox" study by high resolution respirometry combined with fluorometry and spectrofluorometry: NextGen-O2k.
Sumbalova 2015 Abstract MiP2015 2015 High-resolution measurement of mitochondrial membrane potential and respiration – comparison of potentiometric and fluorometric methods.
Gnaiger 2015 Abstract MiP2015 2015 Mitochondrial function of cyropreserved HEK 293T cells: development of a reference sample for high-resolution respirometry.
Hoppel 2015 Abstract MiPschool London 2015 2015 Human blood cell types as study models of mitochondrial respiration and H2O2 production.
Doerrier 2015 Abstract MiP2015 2015 Simultaneous measurement of mitochondrial respiration, hydrogen peroxide production, and NADH autofluorescence to assess mitochondrial function.
Krumschnabel 2014 Abstract MiP2014 2014 Simultaneous high-resolution measurement of mitochondrial respiration and hydrogen peroxide production.
Schoepf 2014 Abstract MiP2014 2014 OXPHOS analysis in small prostate biopsies.
Sumbalova 2014 Abstract MiP2014 2014 Optimization of malate concentration for high-resolution respirometry: mitochondria from rat liver and brain.
Gnaiger 2014 Abstract MiP2014 2014 Cell ergometry: OXPHOS and ETS coupling efficiency.
Burtscher 2014 Abstract MiP2014 2014 Region-specific differences in Complex I- and Complex II-linked respiration in the mouse brain.
Laner 2014 Abstract MiP2014 2014 Cytochrome c flux control factor as a quality criterion in respiratory OXPHOS analysis in canine permeabilized fibres.
Harrison 2014 Abstract MiP2014 2014 The relationship between cytochrome redox state and oxygen consumption in isolated mouse and beef heart mitochondria during hypoxia.
Gnaiger 2014 Preface MiP2014 2014 MiPArt - Mitchell's equation.
Laner 2013 ASMRM 2013 Laner V, Gradl P, Eigentler A, Fontana-Ayoub M, Fasching M, Gnaiger E (2013) The OROBOROS Oxygraph-2k for high-resolution respirometry and O2k-Fluorometry: a new quality in OXPHOS analysis. ASMRM2013.
Gnaiger 2013 Abstract ASMRM 2013 Gnaiger E(2013) Loss of mitochondrial competence and degenerative disease: cause and effect. Abstract ASMRM-Seoul.
Gnaiger 2013 Abstract Mito2013 2013 Gnaiger E, Søndergaard H, Munch-Andersen T, Damsgaard R, Hagen C, Díez-Sánchez C, Ara I, Wright-Paradis C, Schrauwen P, Hesselink M, Calbet J, Christiansen M, Helge JW, Saltin B, Boushel R (2013) Conserved mitochondrial coupling efficiency and adaptive substrate control in Inuit and Caucasians: adaptation and acclimatization to the Arctic winter.
Gnaiger 2013 Abstract Neurocon Kolkata 2013 Gnaiger E (2013) Body mass index and the risk of neurodegeneration: from mitochondrial fitness to brain function. Abstract Neurocon 2013, Kolkata, India. Symposium: Neurocon 2013. January 17-20.
Gnaiger 2013 Abstract MiP2013 2013 Gnaiger E, Søndergaard H, Munch-Andersen T, Damsgaard R, Hagen C, Díez-Sánchez C, Ara I, Wright-Paradis C, Schrauwen P, Hesselink M, Calbet J, Christiansen M, Helge JW, Saltin B, Boushel R (2013) Biochemical coupling efficiency in permeabilized fibres from arm and leg muscle in Inuit versus Caucasians: A functional test of the uncoupling hypothesis in Greenland. Mitochondr Physiol Network 18.08.
Krumschnabel 2013 Abstract MiP2013 2013 Krumschnabel G, Eigentler A, Fontana-Ayoub M, Draxl A, Fasching M, Gnaiger E (2013) Tissue homogenates for respiratory OXPHOS analysis in comparative mitochondrial physiology: mouse and trout – heart and liver. Mitochondr Physiol Network 18.08.
Gnaiger 2013 MiP2013-Opening 2013 Gnaiger E (2013) What is mitochondrial physiology – why comparative? Mitochondr Physiol Network 18.08.
Leo 2012 Abstract Bioblast 2012 Leo H, Gnaiger E (2012) Happiness and mitochrondrial activity. Mitochondr Physiol Network 17.12.
Horvath 2012 Abstract Bioblast 2012 Horvath G, Eigentler A, Gnaiger E, Tretter L (2012) Respiratory substrate effects on mitochondrial membrane potential - experiments with mouse cardiac muscle homogenate. Mitochondr Physiol Network 17.12.
Le 2012 Abstract Bioblast 2012 Le CH, Hocker AD, Dreyer HC, Roach RC, Gnaiger E, Chicco AJ (2012) Two-week acclimatization to 5200m markedly alters substrate utilization and increases OXPHOS efficiency, with no effect on respiratory capacity in skeletal muscle mitochondria. Mitochondr Physiol Network 17.12.
Gnaiger 2012 Abstract-FEPS-Santiago de Compostela 2012 Gnaiger E (2012) Aging and mitochondrial physiology. The effect of exercise and caloric balance on oxidative phosphorylation (OXPHOS). Abstract FEPS, Santiago de Compostela, Spain. Symposium: Advances in Aging and Mitochondria Research. September 08-12.
Stoeger 2012 Abstract Bioblast 2012 Stoeger H, Fontana-Ayoub M, Eigentler A, Gnaiger E (2012) Cell respiration with yeast as a model. Mitochondr Physiol Network 17.12.
Gnaiger 2012 Abstract Bioblast-Gentle Science 2012 Gnaiger E (2012) Gentle Science and the Bioblast Conference. Mitochondr Physiol Network 17.12.
Meissner 2012 Abstract Bioblast 2012 Meissner B, Gnaiger E (2012) Open Innovation. Mitochondr Physiol Network 17.12.
Burtscher J 2012 Abstract Bioblast 2012 Burtscher J, Eigentler A, Gnaiger E, Schwarzer C (2012) Mitochondrial function in the mouse hippocampus. Mitochondr Physiol Network 17.12.
Fasching 2012 Abstract Bioblast 2012 Fasching M, Sumbalova Z, Gnaiger E (2012) O2k-Fluorometry - a MitoCom project. Mitochondr Physiol Network 17.12.
Sumbalova 2012 Abstract Bioblast 2012 Sumbalova Z, Fasching M, Erich Gnaiger E (2012) Evaluation of mitochondrial respiration and membrane potential in mouse brain homogenate. Mitochondr Physiol Network 17.12:61.
Hand 2012 Abstract Bioblast 2012 Patil Y, Gnaiger E, Hand SC (2012) Respiration in embryo lysates reveals diminished Complex I activity and inhibition of the phosphorylation system during diapause in Artemia franciscana. Mitochondr Physiol Network 17.12.
Horscroft 2012 Abstract IOC72 2012 Horscroft JA, Kotwica AO, Ashmore T, Colleoni F, Morash AJ, Gilbert E, Gnaiger E, Martin DS, Murray AJ (2012) Mitochondrial function at altitude in lowland Europeans and highland Sherpas. Mitochondr Physiol Network 17.13.
Kliemt 2012 Abstract Bioblast 2012 Kliemt U, Gnaiger E (2012) Power and efficiency: Tempo giusto in classical music, thermodynamics and industrial revolution, and the speed of life. Mitochondr Physiol Network 17.12.
Eigentler 2012 Abstract Bioblast 2012 Eigentler A, Draxl A, Fontana-Ayoub M, Gnaiger E (2012) The PBI-Shredder - an auxiliary HRR-tool for the preparation of tissue homogenates for diagnosis of mitochondrial respiratory function. Mitochondr Physiol Network 17.12.
Sumbalova 2011 Abstract Mitochondrial Medicine 2011 Sumbalova Z, Fasching M, Gnaiger E (2011) Substrate control in mitochondrial respiration and regulation of mitochondrial membrane potential. Abstract Mitochondrial Medicine Chicago.
Gnaiger 2011 Abstract-MonteVerita 2011 Gnaiger E (2011) Mitochondrial respiratory capacity at maximum aerobic exercise levels: Are intracellular oxygen levels limiting? Abstract Monte Verita.
Gnaiger 2011 Abstract SMRM-Hyderabad 2011 Gnaiger E, Wright-Paradis C, Sondergaard H, Calbet J, Damsgaard R, Munck-Andersen T, Saltin B, Boushel RC (2011) Conserved mitochondrial coupling and adaptive substrate control in Inuit and Caucasians: Acclimatization to active life styles in the Arctic winter. Abstract SMRM-Hyderabad.
Gnaiger 2011 Abstract-Berlin 2011 Gnaiger E (2011) Fewer mitochondria - mitochondrial 'fever': Mitochondrial physiology and capacity of oxidative phosphorylation in active and sedentary life styles. Abstract Targeting Mitochondria Berlin.
Fasching 2011 Abstract Berlin 2011 Fasching M, Harrison DK, Tretter L, Gnaiger E (2011) Combination of high-resolution respirometry and fluorometry for continuous monitoring of hydrogen peroxide production by mitochondria with resolution in the nanomolar range. Abstract Berlin.
Sumbalova 2011 Abstract Kagoshima 2011 Sumbalova Z, Harrison DK, Gradl P, Fasching M, Gnaiger E (2011) Mitochondrial membrane potential, coupling control, H2O2 production, and the upper limit of mitochondrial performance. Abstract Kagoshima.
Burtscher 2011Abstract Mitochondrial Medicine 2011 Burtscher M, Dietrich H, Gatterer H, Gnaiger E, Harrison DK, Karall D, Krismer M, Lass-Floerl C, Parson W, Perkhofer S, Pesta D, Schocke M, Sumbalova Z, Wiethüchter A (2011) Mitochondrial competence. Regional and international cooperation for establishing new standards in functional mitochondrial diagnosis. Abstract Mitochondrial Medicine Chicago.
Gnaiger IOC62-Introduction 2011 Gnaiger E (2011) The elements of high-resolution respirometry: An introduction to the OROBOROS Oxygraph-2k. IOC62.
Sumbalova 2011 Abstract Bordeaux 2011 Sumbalova Z, Wiethuechter A, Fasching M, Gnaiger E (2011) Coupling control and substrate control of mitochondrial membrane potential and respiration in the mouse brain, and comparison with skeletal and cardiac muscle. Abstract MiP2011, Bordeaux.
Pesta 2011Abstract Mitochondrial Medicine-Diagnosis 2011 Pesta D, Wiethuechter A, Karall D, Schocke M, Gnaiger E (2011) Functional mitochondrial diagnosis in a patient suffering from sudden exercise intolerance. Abstract Mitochondrial Medicine Chicago.
Pesta 2011Abstract ACSM 2011 Pesta D, Jacobs R, Macek C, Hoppel F, Faulhaber M, Lundby C, Burtscher M, Gnaiger E, Schocke M (2011) Investigation of muscle metabolism of the quadriceps via high-resolution respirometry and 31P MRS in connection with a 10 week endurance training. Medicine & Science in Sports & Exercise 43: 71
Lemieux 2011 Abstract Bordeaux 2011 Lemieux H, Semsroth S, Antretter H, Hoefer D, Gnaiger E (2011) Increased OXPHOS capacity after cold preservation of the human heart – a paradox resolved by a dyscoupling mechanism. MiP2011
Pesta 2011Abstract Mitochondrial Medicine-Training 2011 Pesta D, Hoppel F, Macek C, Messner H, Faulhaber M, Kobel C, Parson W, Burtscher M, Schocke M, Gnaiger E (2011) Mitochondrial improvements after strength, endurance, and intermittend hypoxic training in sedentary humans. A respiratory study on permeabilized muscle fibres. Abstract Mitochondrial Medicine Chicago.
Gnaiger 2010 Abstract MiP2010 2010 Gnaiger E (2010) Seven years Mitochondrial Physiology Society and a welcome to MiP2010: Bioblasts – the aliens with permanent residence in our cells. Mitochondr Physiol Network 15.6:25-8.
Wiethuechter MiP2010 2010 Wiethuechter A, Gnaiger E (2010) Bioblast wiki.
Pesta 2010 MiP Abstract 2010 Pesta D, Faulhaber M, Burtscher M, Gnaiger E, Schocke M (2010) Investigation of muscle metabolism of the M. quadriceps via 31P MRS and high-resolution respirometry in connection with 10 weeks of strength and endurance training in normoxia and hypoxia. MiP2010.
Gnaiger Abstract MiP2010 2-01 2010 Gnaiger E (2010) Measuring the upper limit of mitochondrial performance - how and why?
Gnaiger MiP2010 7-03 2010 Gnaiger E (2010) MiPArt exhibition “The Beauty of Mitochondria”
Pesta 2010 Abstract IOC60 2010 Pesta D, Macek C, Hoppel F, Faulhaber M, Burtscher M, Gnaiger E, Schocke M (2010) The impact of endurance training on muscle oxidative capacity. MiPNet15.10.
Gnaiger MiP2010 2010 Gnaiger E, Renner-Sattler K (2010) FEBS Workshop: Mitochondrial Physiology. The Many Functions of the Organism in Our Cells.
Lemieux 2006 Biochim Biophys Acta 2006 Lemieux H, Garedew A, Blier PU, Tardif J-C, Gnaiger E (2006) Temperature effects on the control and capacity of mitochondrial respiration in permeabilized fibers of the mouse heart. Biochim Biophys Acta, EBEC Short Reports Suppl 14 (2006):201-2.
Garedew 2006 Biochim Biophys Acta 2006 Garedew A, Lemieux H, Schachner T, Blier PU, Tardif J-C, Gnaiger E (2006) High excess capacity of cytochrome c oxidase in permeabilized fibers of the mouse heart. Biochim Biophys Acta, EBEC Short Reports Suppl 14 (2006):167-8.
OROBOROS


Contents


CURRICULUM VITAE

Erich Gnaiger

D. Swarovski Research Laboratory
Department of Visceral, Transplant and Thoracic Surgery
Medical University of Innsbruck
A-6020 Innsbruck, Austria
Tel: +43 512 5667960
Email: erich.gnaiger@oroboros.at
Erich Gnaiger has scientific and technical expertise in the fields of mitochondrial physiology and pathology, microcalorimetry and biological thermodynamics, contributing fundamentally to the understanding of mitochondrial respiratory control by oxygen, and development and application of high-resolution respirometry to cellular bioenergetics and the diagnosis of mitochondrial defects, particularly in relation to hypoxia, cold storage and ischemia-reperfusion injury. He is initiator (2003) and chairman of the International Mitochondrial Physiology Society (MiP; www.mitophysiology.org), and has organized numerous conferences (particularly MiP2003, MiP2005 and MiP2010 in Austria), workshops (more than 100 international workshops on high-resolution respirometry), and training courses on mitochondrial physiology, bioenergetics and biological thermodynamics, and is editor of several proceedings of international meetings. The international teaching activities range from non-equilibrium thermodynamics for chemical engineers (EU-level training; member of the IUPAC steering committee on biological thermodynamics) to mitochondrial physiology (Innsbruck Summer School 1991; initiator of the MiPsummer Schools 2007, 2008 in Austria; 2009 in Louisiana, US; 2010 in Lithuania). Erich Gnaiger is member of the editorial board of the journal ‘Mitochondrion’. He is Chair of the COST Action CA15203 MITOEAGLE (2016-2020).
OROBOROS
Erich Gnaiger is the founder of the company OROBOROS INSTRUMENTS (www.oroboros.at) with world-wide technological leadership in high-resolution respirometry and reference laboratories in more than 40 countries. The cooperation between academia (Medical University of Innsbruck) and industry (OROBOROS INSTRUMENTS) is formalized in a K-Regio Centre of Excellence with the projects MitoCom Tyrol and MitoFit coordinated by Erich Gnaiger. Erich Gnaiger is initiator of ‘Gentle Science’ (www.bioblast.at).


MiPsociety Chairperson of the Mitochondrial Physiology Society - http://www.mitophysiology.org


Academic training
1985: Habilitation: Stoichiometric and calorimetric principles of aerobic and anaerobic energy budgets and thermodynamic optimization in metabolic economy: Rate and power, versus efficiency. University of Innsbruck, Department of Zoology.
1974-80: University of Innsbruck, graduate, zoophysiology, limnology and biochemistry.
Ph.D. thesis: Direct calorimetry and bioenergetics: aerobic and anoxic metabolism in aquatic oligochaetes. Dept. Zoology, University of Innsbruck.
1970-74: University of Vienna, undergraduate, zoology and biochemistry.


Positions held
1993 -Cooperation with Univ.-Prof. Dr. R. Margreiter, initiating and leading the research laboratory associated with the Department of Transplant Surgery, Medical School, University of Innsbruck; A.Univ.-Prof.; D. Swarovski Research Laboratory, Department of Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, Austria.
1999 -Honorary Professor, Dept. Biol. Sci., Univ. Wales, Aberystwyth, UK.
1992-99 Honorary Fellow, Dept. Biol. Sci., Univ. Wales, Aberystwyth, UK.
1989-92 Research position, Austrian Science Foundation FWF and FFF.
1986-88 FWF Erwin Schrödinger Fellowship (USA)
1985-92 Research Assistant Professor, Dept. Zool., Univ. Innsbruck, Austria.
1984-85 Research Assistant and Lecturer, Dept. Zool., Univ. Innsbruck
1982-83 Postdoctoral position, Inst. Marine Environ. Research, Plymouth, UK.
1980-81 Austrian Science Foundation FWF, postdoctoral associate, Dept. Zool., Univ. Innsbruck.
1980-81 Lecturer, Dept. Zool., Univ. Innsbruck.
1974-80 Austrian Science Foundation research assistant, Dept. Zool., Univ. Innsbruck.


Research support
COST Action MITOEAGLE COST Action MITOEAGLE - Chair
MitoFit K-Regio MitoFit
MitoCom logo based on MiPArt by Odra Noel
K-Regio, MitoCom Tyrol


COST Action TD0901 HypoxiaNet.
COST Action FA0602 Mitofood.
Marsden, Univ. Auckland, New Zealand.
FEBS Workshop Grant.
Austrian Science Foundation, FWF.
Austrian Science Foundation for Commerce FFF (now FFG).
Austrian Ministry of Science.
Austrian Ministry of the Environment.
Community Action Programme in Education and Training for Technology, COMETT.
ÖAD Acciones Integradas: Innsbruck-Barcelona; Innsbruck-Madrid.
Swedish National Science Foundation; co-PI with Dr. L. Gustafsson, Univ Gothenburg, Sweden.
Erwin-Schrödinger Fellowship, Austria (UK and USA).
British Council Postdoctoral Fellowship, UK.


Awards
2012 Houska Award 2011 (Vienna, AT, Apr 2012)
2003 Lavoisier award of the International Society of Biological Microcalorimetry (Würzburg, DE, Oct 2003)
1999 Honorary Professor, Dept. Biol. Sci., Univ. Wales, Aberystwyth, UK.


Selected publications

Selected conference proceedings / edited books

  1. Gnaiger E (2014) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 4th ed. Mitochondr Physiol Network 19.12. OROBOROS MiPNet Publications, Innsbruck:80 pp. - »Bioblast link«
  2. Laner V, Gnaiger E, eds (2014) Mitochondrial physiology – methods, concepts and biomedical perspectives. MiP2014. Mitochondr Physiol Network 19.13:88 pp. - »Bioblast link«
  3. Laner V, Bidaurratzaga E, Gnaiger E, eds (2013) Comparative Mitochondrial Physiology. MiP2013. Mitochondr Physiol Network 18.08:96 pp. - »Bioblast link«
  4. Gnaiger E, Meissner B, Laner V, eds (2012) Bioblast 2012: Mitochondrial Competence. Mitochondr Physiol Network 17.12. OROBOROS MiPNet Publications, Innsbruck: 96 pp. »Open Access
  5. Renner-Sattler K, Gnaiger E, eds (2010) Mitochondrial physiology. The many functions of the organism in our cells. Mitochondr Physiol Network 15.6: 128 pp. »MiP2010
  6. Gnaiger E, Gellerich FN, Wyss M, eds (1994) What is Controlling Life? 50 Years after Erwin Schrödinger's What is Life? Modern Trends in BioThermoKinetics 3. Innsbruck Univ. Press, Innsbruck: 336 pp. »Open Access
  7. Wieser W, Gnaiger E, eds (1989) Energy Transformations in Cells and Organisms. Thieme Publ., Stuttgart: 330 pp.
  8. Gnaiger E, Forstner H, eds (1983) Polarographic Oxygen Sensors. Aquatic and Physiological Applications. Springer, Berlin, Heidelberg, New York: 370 pp. »Bioblast Access

Selected publications 2010-

  1. Schöpf B, Schäfer G, Weber A, Talasz H, Eder IE, Klocker H, Gnaiger E (2016) Oxidative phosphorylation and mitochondrial function differ between human prostate tissue and cultured cells. FEBS J. - »Bioblast link«
  2. Gnaiger E, Boushel R, Søndergaard H, Munch-Andersen T, Damsgaard R, Hagen C, Díez-Sánchez C, Ara I, Wright-Paradis C, Schrauwen P, Hesselink M, Calbet JAL, Christiansen M, Helge JW, Saltin B (2015) Mitochondrial coupling and capacity of oxidative phosphorylation in skeletal muscle of Inuit and caucasians in the arctic winter. Scand J Med Sci Sports 25 (Suppl 4):126–34. - »Bioblast link«
  3. Harrison DK, Fasching M, Fontana-Ayoub M, Gnaiger E (2015) Cytochrome redox states and respiratory control in mouse and beef heart mitochondria at steady-state levels of hypoxia. J Appl Physiol Aug 6:jap.00146.2015. doi: 10.1152/japplphysiol.00146.2015. - »Bioblast link«
  4. Burtscher J, Zangrandi L, Schwarzer C, Gnaiger E (2015) Differences in mitochondrial function in homogenated samples from healthy and epileptic specific brain tissues revealed by high-resolution respirometry. Mitochondrion 25:104-12. - »Bioblast link«
  5. Pesta D, Gnaiger E (2012) High-resolution respirometry. OXPHOS protocols for human cells and permeabilized fibres from small biopisies of human muscle. Methods Mol Biol 810:25-58. - »Bioblast link«
  6. Votion DM, Gnaiger E, Lemieux H, Mouithys-Mickalad A, Serteyn D (2012) Physical fitness and mitochondrial respiratory capacity in horse skeletal muscle. PLoS One 7:e34890. - »Bioblast link«
  7. Lemieux H, Semsroth S, Antretter H, Höfer D, Gnaiger E (2011) Mitochondrial respiratory control and early defects of oxidative phosphorylation in the failing human heart. Int J Biochem Cell Biol 43:1729–38. - »Bioblast link«
  8. Pesta D, Hoppel F, Macek C, Messner H, Faulhaber M, Kobel C, Parson W, Burtscher M, Schocke M, Gnaiger E (2011) Similar qualitative and quantitative changes of mitochondrial respiration following strength and endurance training in normoxia and hypoxia in sedentary humans. Am J Physiol Regul Integr Comp Physiol 301:R1078–87. - »Bioblast link«
  9. Scandurra FM, Gnaiger E (2010) Cell respiration under hypoxia: Facts and artefacts in mitochondrial oxygen kinetics. Adv Exp Med Biol 662:7-25. - »Bioblast link«

12 Selected Publications: 2000-2009

  1. Gnaiger E (2009) Capacity of oxidative phosphorylation in human skeletal muscle. New perspectives of mitochondrial physiology. Int J Biochem Cell Biol 41:1837–45. - »Bioblast link«
  2. Aragonés J, Schneider M, Van Geyte K, Fraisl P, Dresselaers T, Mazzone M, Dirkx R, Zacchigna S, Lemieux H, Jeoung NH, Lambrechts D, Bishop T, Lafuste P, Diez-Juan A, K Harten S, Van Noten P, De Bock K, Willam C, Tjwa M, Grosfeld A, Navet R, Moons L, Vandendriessche T, Deroose C, Wijeyekoon B, Nuyts J, Jordan B, Silasi-Mansat R, Lupu F, Dewerchin M, Pugh C, Salmon P, Mortelmans L, Gallez B, Gorus F, Buyse J, Sluse F, Harris RA, Gnaiger E, Hespel P, Van Hecke P, Schuit F, Van Veldhoven P, Ratcliffe P, Baes M, Maxwell P, Carmeliet P (2008) Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism. Nat Genet 40:170-80. - »Bioblast link«
  3. Boushel R, Gnaiger E, Schjerling P, Skovbro M, Kraunsøe R, Dela F (2007) Patients with Type 2 Diabetes have normal mitochondrial function in skeletal muscle. Diabetologia 50:790-6. - »Bioblast link«
  4. Stadlmann S, Renner K, Pollheimer J, Moser PL, Zeimet AG, Offner FA, Gnaiger E (2006) Preserved coupling of oxydative phosphorylation but decreased mitochondrial respiratory capacity in IL-1β treated human peritoneal mesothelial cells. Cell Biochem Biophys 44:179-86. - »Bioblast link«
  5. Hütter E, Renner K, Pfister G, Stöckl P, Jansen-Dürr P, Gnaiger E (2004) Senescence-associated changes in respiration and oxidative phosphorylation in primary human fibroblasts. Biochem J 380:919-28. - »Bioblast link«
  6. Kuznetsov AV, Schneeberger S, Seiler R, Brandacher G, Mark W, Steurer W, Saks V, Usson Y, Margreiter R, Gnaiger E (2004) Mitochondrial defects and heterogeneous cytochrome c release after cardiac cold ischemia and reperfusion. Am J Physiol Heart Circ Physiol 286:H1633–41. - »Bioblast link«
  7. Gnaiger E (2003) Oxygen conformance of cellular respiration. A perspective of mitochondrial physiology. Adv Exp Med Biol 543:39-56. - »Bioblast link«
  8. Renner K, Amberger A, Konwalinka G, Kofler R, Gnaiger E (2003) Changes of mitochondrial respiration, mitochondrial content and cell size after induction of apoptosis in leukemia cells. Biochim Biophys Acta 1642:115-23. - »Bioblast link«
  9. Gnaiger E, Kuznetsov AV (2002) Mitochondrial respiration at low levels of oxygen and cytochrome c. Biochem Soc Trans 30:252-8. - »Bioblast link«
  10. Stadlmann S, Rieger G, Amberger A, Kuznetsov AV, Margreiter R, Gnaiger E (2002) H2O2-mediated oxidative stress versus cold ischemia-reperfusion: mitochondrial respiratory defects in cultured human endothelial cells. Transplantation 74:1800-3. - »Bioblast link«
  11. Gnaiger E (2001) Bioenergetics at low oxygen: dependence of respiration and phosphorylation on oxygen and adenosine diphosphate supply. Respir Physiol 128:277-97. - »Bioblast link«
  12. Gnaiger E, Méndez G, Hand SC (2000) High phosphorylation efficiency and depression of uncoupled respiration in mitochondria under hypoxia. Proc Natl Acad Sci U S A 97:11080-5.»Bioblast link«


12 selected publications: up to 1999

  1. Oexle H, Gnaiger E, Weiss G (1999) Iron-dependent changes in cellular energy metabolism: influence on citric acid cycle and oxidative phosphorylation. Biochim Biophys Acta 1413:99-107. - »Bioblast link«
  2. Gnaiger E, Lassnig B, Kuznetsov AV, Rieger G, Margreiter R (1998) Mitochondrial oxygen affinity, respiratory flux control and excess capacity of cytochrome c oxidase. J Exp Biol 201:1129-39. - »Bioblast link«
  3. Gnaiger E, Lassnig B, Kuznetsov AV, Margreiter R (1998) Mitochondrial respiration in the low oxygen environment of the cell. Effect of ADP on oxygen kinetics. Biochim Biophys Acta 1365:249-54. - »Bioblast link«
  4. Steinlechner-Maran R, Eberl T, Kunc M, Schröcksnadel H, Margreiter R, Gnaiger E (1997) Respiratory defect as an early event in preservation/reoxygenation injury in endothelial cells. Transplantation 63:136-42. - »Bioblast link«
  5. Steinlechner-Maran R, Eberl T, Kunc M, Margreiter R, Gnaiger E (1996) Oxygen dependence of respiration in coupled and uncoupled endothelial cells. Am J Physiol Cell Physiol 271:C2053-61. - »Bioblast link«
  6. Gnaiger E, Steinlechner-Maran R, Méndez G, Eberl T, Margreiter R (1995) Control of mitochondrial and cellular respiration by oxygen. J Bioenerg Biomembr 27:583-96. - »Bioblast link«
  7. Gnaiger E (1993) Efficiency and power strategies under hypoxia. Is low efficiency at high glycolytic ATP production a paradox? In Surviving Hypoxia: Mechanisms of Control and Adaptation. Hochachka PW, Lutz PL, Sick T, Rosenthal M, Van den Thillart G (eds) CRC Press, Boca Raton, Ann Arbor, London, Tokyo:77-109. - »Bioblast link«
  8. Von Stockar U, Gustafsson L, Larsson C, Marison I, Tissot P, Gnaiger E (1993) Thermodynamic considerations in constructing energy balances for cellular growth. Biochim Biophys Acta 1183:221-40. - »Bioblast link«
  9. Buck LT, Hochachka PW, Schön A, Gnaiger E (1993) Microcalorimetric measurement of reversible metabolic suppression induced by anoxia in isolated hepatocytes. Am J Physiol 265:R1014-19. - »Bioblast link«
  10. Gnaiger E (1993) Nonequilibrium thermodynamics of energy transformations. Pure Appl Chem 65:1983-2002. - »Bioblast link«
  11. Gnaiger E, Kemp RB (1990) Anaerobic metabolism in aerobic mammalian cells. Information from the ratio of calorimetric heat flux and respirometric oxygen flux. Biochim Biophys Acta 1016:328-32. - »Bioblast link«
  12. Hand SC, Gnaiger E (1988) Anaerobic dormancy quantified in Artemia embryos: A calorimetric test of the control mechanism. Science 239:1425-7. - »Bioblast link«


The world as a laboratory

Expeditions: The world as a laboratory

Erich Gnaiger, Wolstenhjolm Fjord Greenland March 2004
Northern Greenland 2004
Monte Rosa, Italy 2004
Mt. Chacaltaya, Bolivia 2012
Everest Base Camp, Nepal 2013
Racing dogs at Iditarod, Alaska 2014
» Racing dogs Alaska, IOC84
To the heart of the Amazon, Manaus 2015


Websites


MitoFit

MitoFit

MitoFit is a consortium of academic and industrial partners for integrative research in mitochondrial physiology and pathology. MitoFit (Universities of Innsbruck, OROBOROS INSTRUMENTS, WGT Elektronik, Austria) supports international mitochondrial networks, for exchange of expertise and standardization of diagnostic approaches, in a joint effort to helping mitochondrial patients and making a difference to society. The project MitoCom Tyrol (2011-2014) was a milestone in the establishment of MitoFit, supported by K-Regio to promote science, research and development within the area of Tyrol.
Preservation, gain or loss of mitochondrial fitness plays an increasing role in therapeutic and preventive medicine, with exercise and caloric balance ranking among the most effective measures for the reduction of several age-related health risks and degenerative diseases. Evaluation of mitochondrial competence requires improved methods and concepts for the diagnosis of mitochondrial functions and mitochondrial injuries, and represents a current challenge for biomedical research and development. MitoFit is a gateway to better diagnose, support and treat patients in our modern, rapidly ageing society.
Further information:
MitoGlobal Member of Mitochondrial Global Network Centres
Company of Scientists Founder of the Company of Scientists


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