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...g applications. In contrast, the number of publications from North America has been relatively modest. Here, we review the field of nonequilibrium thermod

{{Abstract |abstract=Fatty acid oxidation in permeabilized muscle fibers has worked well for us in both human and rat studies. Typically we use Octanoyl

== Abstract == ...d for general, pre-clinical, and algal biotechnology applications. A focus has also been given to internal and external quality control measures.

...oan development, physiology, and disease pathogenesis. Remarkable progress has been made in delineating the molecular mechanisms whereby changes in cellul

...in regulating cellular function. The discovery of the mCa2+ uptake complex has shed new light on the role of mCa2+ dynamics in cytoskeletal remodeling, mi

{{Abstract ...ion dynamin related protein 1 (DRP1) has been recently challenged and Fis1 has been conversely implied in mitophagy, but the molecular mechanisms governin

|abstract=Skeletal muscle insulin resistance (IR) is inextricably likely has many mechanistic origins, but the primary

...has been expressed in Escherichia coli, and the recombinant human protein has the same kinetic properties as the corresponding protein purified from bovi

{{Abstract |abstract=[[Image:MITOEAGLE-logo.jpg|left|100px|link=http://www.mitoglobal.org/index.

{{Abstract ...mtDNA mutation for Lebers Hereditory Optic Neuropathy (LHON), this service has expanded to include a number of mtDNA mutations as well as some nuclear gen

...in circulation, and angiogenesis at sites of metastases. Low-dose aspirin has been demonstrated to block this procarcinogenic action of platelets. In thi

...differentiated generation stage once the appropriate developmental program has been engaged and also indicate that ORO is a key member of the developmenta

...nation and is completed in under 5 minutes, and mass spectroscopy analysis has shown enrichment of mitochondrial metabolites. Seahorse and Oroboros analys

...Our analysis proves, therefore, that the role of opportunism in evolution has converted a problem of several possible chemical solutions into a single-so

...tly the CoQ10H2/CoQ10 ratio changes considerably soon after a blood sample has been obtained. The time period since blood sampling and HPLC analysis, as w

|abstract=BACKGROUND: During the past 40 y, there has been a trend toward more eating away from home, increased food availability ...ur goal was to determine whether the body mass index (BMI)-height relation has changed over time.

...specified pure number of elementary entities. Hence the Avogadro constant has always been defined in terms of the unit of amount of substance, and not vi

|abstract= ASMRM 2020, Singapore, SG, 2021 '''This event has been postponed'''

...ascular events has been widely described. Thus, increased oxidative stress has been described in several atherosclerotic risk factors, such as hypertensio

|abstract=[[Komlodi 2022 Abstract Bioblast]]: The protonmotive force ''pmF'' establishes the link between ele ...al processes, such as production of reactive oxygen species, where the ΔpH has an important role.

...molecular machinery regulating mitochondrial Ca2+ accumulation and efflux has expanded the number of (patho)physiological conditions that rely on mitocho

...cal barriers. Mapping CoQ biosynthesis, metabolism, and transport pathways has great potential to enhance treatment of numerous human diseases.

...decline occurs as humans age. Increasing research on mitochondrial biology has elucidated the regulatory pathways involved in mitochondrial biogenesis, ma

|abstract=Chronic heart failure (CHF) is characterised by an inability of the heart t in nitric oxide (NO) bioavailability has been implicated as an initiator and/or contributor

...2+. Although ion-selective microelectrodes are widely used, this technique has certain assumptions, problems, and limitations that vary with the types of

|abstract=<big>'''Journal publication 2021-06-30 in [https://www.bioenergetics-commun |?Has title=Reference

...r investigators do not support a simple model in which climatic adaptation has been a major force during human mtDNA evolution.

...on. However, no protein candidate proposed as the actual pore-forming unit has passed rigorous gain- or loss-of-function genetic tests. Here we review evi

...ause of aging has been discussed over last decades. Accumulating evidences has indicated that genome instability including mitochondrial DNA in somatic ce

...l lines, including HeLA, HepG2, and skeletal muscle cells. As of yet, this has not been reproduced in neuronal cells. Using Neuro2a, a murine neuroblastom

...observations provide insights into eukaryotic NADP(+) biosynthesis, which has pivotal roles in cells and organelles.

...tained at -0.600 V vs Ag/AgCl. The magnitude of the oxidation peak current has been found to be related to the concentration of the coenzyme over the rang

...fully revealed. Owing to its safety and potential efficacy, H₂ has a promising potential for clinical use against many diseases. This review w

...bstrate for Complex II which accumulates during mitochondrial dysfunction, has been shown to have widespread effects as a signaling molecule. Here, we rev

{{Abstract ...mitochondria in a tissue. In patients with peripheral arterial disease it has been shown that the function and the amount of mitochondria depends on the

...erformed. Such as sample has to be stable for a certain amount of time and has to deliver the same results over and over ...nts have been done in certain intervals. The process of shipping the cells has also been mimicked by storing cells in a -20°C freezer for the period of o

...ondria and low oxidative capacity. The heat-producing brown adipose tissue has a high density of mitochondria and high oxidative capacity. Mitochondrial f

...nstruction of PI curves of unicellular organisms based on oxygen evolution has been difficult and time consuming due to the lack of sensitive instruments. :::: Supported by project [[NextGen-O2k]] which has received funding from the European Union’s Horizon 2020 research and inno

{{Abstract ...at an impaired mitochondrial function in one tissue (e.g. skeletal muscle) has strong metabolic consequences for the whole organism.

...and international trade, ''Where Corals Lie'' reveals how the threatening has become threatened; and of the danger this poses to humans. Exceptionally em

|abstract=.. From the start of my scientific career the galvanic cell, the first form ...appreciable elaboration since its acceptance, surely a clear sign that it has so far satisfied scientific needs. ..

...reviewed, a clear understanding of the regulation of cellular respiration has not yet been achieved. In particular, the role of tissue pO2 as a factor re cellular and intercellular messengers has evolved in the last few years and is

...t times of infection. Taking together, these results demonstrated that DHA has a potential anti-inflammatory and neuroprotective effect against ZIKV infec

{{Abstract ...lth consequences associated with excess weight, to the extent that obesity has recently been classified as a disease. Calorie restriction can induce weigh

...ax</sub>) with respect to ubiquinol-10 have been determined. The PL system has also been employed in dose-response assays with novel AOX inhibitors. Such

...tract=The interplay between platelets and tumors has long been studied. It has been widely accepted that platelets could promote tumor metastasis. However

...ts impair the specificities of cancer drugs. Blockade of kinase activities has been shown to converge on the energetic organelle, the mitochondria. In thi

...as important causes of disease. In addition, the study of these disorders has led to a greater understanding of the molecular mechanism of beta-oxidation

...e material into the body's own tissue. Unfortunately, however, this method has not yet arrived in practice. Therefore, we have made our own efforts to est

{{Abstract ...using reverse transcriptase polymerase chain reaction (RT-PCR) experiments has demonstrated that these genes are transcribed in many organisms [3]. Our fo

...nucleotide pool from tissue is dependent on the assay method. NADH ED-FRAP has been shown to be effective in measuring dehydrogenase activity in several e

...m of tissue cannot be obtained. Often, 0.5 grams must suffice. This method has been used successfully for the isolation of heart mitochondria from several

...electron transfer chain impairments, mitochondrial apoptosis and mitophagy has been outlined. Meanwhile, considerable efforts have been made towards under

{{Abstract ...efficiency through uncoupling. Mitochondrial heat generation in bumblebees has been largely discounted as they appear to lack uncoupling proteins, and if

...stress. This study aimed to demonstrate whether exercise before pregnancy has a protective effect on prenatal stress-induced impairment of memory, neurog

...ny such special properties. We review evidence here showing that trehalose has a remarkably high glass-transition temperature (Tg). It is not anomalous in

...t includes administering to the subject a pharmaceutical composition which has a therapeutically effective amount of an antimicrobial peptide containing a

...circulating to distant tissues. It is noteworthy that increasing evidence has demonstrated that mitokines are capable of reducing the metabolic-related H

|abstract=Worldwide, 1 in 3 women and 1 in 5 men over age 50 will experience fracture decline of bone with aging has been well studied, we were the first to find a

|abstract= TRACT General assembly meeting, Belfast, United Kingdom, 2018 This project has received funding from the European Union's Horizon 2020 research and innova

...ng, while itaconate (from another Krebs cycle intermediate, cis-aconitate) has an anti-inflammatory role.

...egulate autophagy and mitochondrial quality control. Conversely, autophagy has been shown to preserve NAD levels by modulating cellular stress. In this re

...ort chain into higher order assemblies, termed respiratory supercomplexes, has been established. Moreover, cardiolipin is involved in different stages of

...majority of the literature is not supporting this hypothesis. Recently it has been suggested that the production of reactive oxygen species play an essen

{{Abstract |abstract=[[Image:MITOEAGLE-logo.jpg|left|100px|link=http://www.mitoglobal.org/index.

|abstract= 32nd APS Annual Convention, Chicago, USA, 2020 :::: APS has regrettably determined it has no alternative but to cancel our in-person 32nd APS Annual Convention in Ch

...system in the cristae membrane under a mainly electrical p.m.f., Baum [6] has asked how the very small number of free protons in the inner aqueous phase

...ations in mitochondrial DNA on the rate of mitochondrial protein synthesis has revealed the existence of a 'translational threshold effect'. In this revie

|abstract=The subunit structure of oligomycin sensitive ATPase has been determined. In addition to the components of F1, and the so-called oli

...ace-water oxygenation. The discovery and cultivation of the Asgard archaea has reinforced metabolic evidence that eukaryogenesis was initially mediated by

{{Abstract ...ts impair the specificities of cancer drugs. Blockade of kinase activities has been shown to converge on the energetic organelle, the mitochondria. In thi

...tions have directed researchers towards utilising stem cells. Mitochondria has a major involvement in the pathophysiology of stroke and a number of other

...ure, the active site and quinone-binding site. Characterisation of the AOX has advanced considerably over recent years with information emerging about the

...cted debate. By contrast, recent application of molecular biological tools has brought major enlightenment at an exponential pace. Here we review some key

...lymphoid malignancies. An initial insufficient response to glucocorticoids has been shown to be an important prognostic marker for a bad outcome. Prior work has shown a downregulation of the mitochondrial glutamate/H+-symporter (SLC25A2

...rd party assessment and caution needed to prevent post-assessment pitfalls has been dealt with.

|title=Bhalla N (2016) Has the time come for preprints in biology? Mol Biol Cell 27:1185-7. |abstract=Preprints, non-peer-reviewed drafts of manuscripts available on the Interne

...nce in the study of cellular metabolism, particularly in the cancer field, has highlighted the fact that mitochondria are also critical biosynthetic and s

|abstract=[[Gnaiger 2022 Abstract Bioblast-PB]]: The bioenergetic crosstalk between mitochondria and chloropl |?Has title=Reference

...the tetrameric interfacial exo site resulted in dimeric mutants. ATP thus has dual functional roles in the mitochondrial malic enzyme.

...piratory defects and neuronal death has never been proven, this hypothesis has been supported by the detection of nonspecific mitochondrial DNA mutations

...igher risk. Although the prevalence of silent hypoxia in COVID-19 patients has been evident in several cases, the underlying pathomechanism behind this co

...stry, biology and nanoscience where counting measurements are common. This has caused debates about how the SI should address counting quantities and the

{{Abstract ...shown to localize in the brain. The unexpected presence of NOX in neurons has led to the idea that NOX-induced ROS are important in non-host defense cont

{{Abstract ...a role in the skeletal muscle wasting seen with DOX treatment. Recent work has shown that Metformin (MET) may protect against this oxidative environment b

...te and adenosine triphosphate have been determined as a function of pH. It has been found that the resonance absorption of the ''β''-P of adenosine triph

|abstract= 24th Kalorimetrietage, Braunschweig, Germany, 2021. ::::* Fromme Tobias: [[Fromme 2021 Abstract Kalorimetrietage |Application of different respirometric assay systems to c

{{Abstract |title=Lane N (2010) Mitochondria and the origin of complex life. Abstract MiP2010.

...een short- and long-term drug resistance mechanisms. Resultantly, FROST450 has the potential to be an important treatment option for cancer patients.

...0.55. It appears, therefore, that the isotope effect is more complex than has heretofore been assumed.

|abstract=SIGNIFICANCE: It is increasingly clear that proline metabolism plays an imp ...d redox cycling and maintenance of pyridine nucleotides. The reprogramming has been shown to shift in clonogenesis and/or metastasis.

...Gln-tRNAGln has to be formed by an indirect mechanism in the organelle. It has been demonstrated that human mitochondria contain a non-discriminating glut

== Abstract == ...ving mitochondrial function (Tab. 1). Mitochondrial respiratory competence has been reported in mononuclear human blood cells directly after storage at -8

...te its effects at a behavioral, morphological and biochemical levels. 3-NP has been used to reproduce the biochemical and pathophysiological characteristi

...t about ambiguity before Empson; as a result, the nature of his innovation has been poorly understood. ...other or both of two things has been meant, and the fact that a statement has several meanings.

...from abroad because the data are reported in unfamiliar terms. The system has broad immediate and future implications to American physicians.

...made to cover the varied aspects of anaerobic bacteria, and a bibliography has been included, which will allow individual topics to be pursued in greater ...n usefully with consequent increased growth, and the term ''anoxybiontic'' has been used to describe this situation.

...to proton translocation by an unknown mechanism. Dysfunction of complex I has been implicated in many human neurodegenerative diseases. We have determine

...the dissociation constant of the fluorescent indicator fura-2 for calcium has been determined in a physiologic buffer at 22 and 37 degrees C. For practic

|abstract= MitoGlobal This project has received funding from the European Union's Horizon 2020 research and innova

...medical scientists actually made a start earlier, reveals a researcher who has traced the "forgotten experiment" in which the National Institutes of Healt

{{Abstract ...ve phosphorylation in lymphocyte and subsequently improves immune function has not yet been established. This study elucidates how interval and continuous

|abstract=Proteomic analysis of early and late endosomes has been constrained by the limited purity of the endosomal fractions that can

...d we also consider other neurodegenerative diseases where oxidative stress has been implicated. Although much data remain to be collected, the broad spect

{{Abstract |abstract=The journal ''[[Bioenergetics Communications]]'' (BEC) was launched in the

|abstract=<big>'''Journal publication 2021-12-21 in [https://www.bioenergetics-commun ...e:Komlodi 2021 MitoFit AmR-O2 graphical abstract.png|right|300px|Graphical abstract]]The fluorometric Amplex UltraRed AmR assay is frequently used for quantita

...ic particles and no lipid phase transition at 14 degrees C in mitochondria has been reported.

|abstract=Dysfunctional bioenergetics has emerged as a key feature inmany This has led to the mitochondrial paradigm in which it has been

...steps of the citric acid cycle (Krebs cycle, tricarboxylic acid TCA cycle) has been characterized by the kinetic and regulatory properties of the enzymes |?Has title=Reference

|abstract=[[File:BEC.png|25px|link=https://www.bioenergetics-communications.org/index :::: Supported by project NextGen-O2k which has received funding from the European Union’s Horizon 2020 research and inno

...rgence and diversification, if any, has been intensely debated. Discussion has gravitated toward threshold levels of environmental free oxygen (O2) necess

...cientific invention. Reaven’s utterances proved pivotal, and nothing since has carried the gravitas of his proclamation. Aibo, on the other hand, will be ...inued dominance of our hunter–gatherer predecessors. But natural selection has turned on us. Life now favours inefficient phenotypes who fail to store ene

|abstract=mtFOIE GRAS Mid-term meeting, Pisa, Italy, 2018 This project has received funding from the European Union's Horizon 2020 research and innova

...onsidered as a body temperature of 36.4 to 37.8 °C. Normothermia, however, has a different definition in the context of [[ectotherms]]. ...itochondr Physiol Network MiP2013 | comparative mitochondrial physiology]] has become a hot topic where '''normothermia''' needs careful consideration.

..., Levitch, Dogonadze, and Jortner.5–11 For more than half of a century, ET has become an important ingredient in many modern research themes, which this s ...two-state and multi-state problems has been useful not only for ET, but it has also influenced the understanding of other processes, such as energy transf

...eration cell-permeable succinate prodrug to support mitochondrial function has positive overall effects in blunting the resultant bioenergy responses. Our

|abstract=Intracellular energy distribution has attracted much interest and has been proposed to occur in skeletal muscle via metabolite-facilitated diffus

|abstract=The mitochondrial respiratory chain has the crucial function of supplying the cell with energy in the form of ATP.

...demonstrate the control of mitochondrial mRNA synthesis by a protein that has an established role in regulating nuclear transcription and a link to mitoc

{{Abstract ...in sickness. Despite these negative effects, intermittent hypoxia exposure has been shown to be beneficial in some cases and the potential therapeutic ben

...e, Mendelian locus that was unlinked to the IMMEDIATE UPRIGHT locus, which has been shown to be necessary for full expression of the sporophyte developmen

...ross the membrane. It has a central role in cellular energy production and has been implicated in many human neurodegenerative diseases. The L-shaped enzy

...s normal kidney function. Improving mitochondrial homeostasis and function has the potential to restore renal function, and administering compounds that s

|abstract= Career Event of the FH Campus Wien, Virtual, 2021 ::::: 1st round: brief introduction of speakers, so that the audience has an idea of the background

...In this work we demonstrate, for the first time, that uncoupling protein 1 has the potential to regulate reactive oxygen species production in thymus mito

|abstract=Quantifying total cellular ATP production rate has become easier with recent technology and is essential to understanding ener

...volved have been only partially determined. Moreover, a synergistic effect has been found in several cancer types when it is administered in combination w

...are likely to play some role in reperfusion injury, priority and emphasis has been given to specific ROS sources that are enriched in certain tissues, su

|abstract= ..., such as the International Prototype of the Kilogram (IPK). The (general) abstract unit ‘kilogram’ had to be calibrated in balance against an (individual)

{{Abstract ...cise) is challenging and unfortunately the success rate is low. This topic has received major attention and yet the explanation behind the apparent inabil

...und after in vivo application of T(3). Our data thus demonstrate that T(3) has an important role in opening the mitochondrial membrane permeability pore a

...y provide a new effective molecular biomarker for the cancer detection. It has been suggested that establishing mtDNA defective pattern might be useful in

...catalyzing sulfide oxidation to thiosulfate in three consecutive reactions has been identified in rat liver as well as in the body-wall tissue of the lugw

...National Laboratory. This evolved into the “preprint” server arXiv, which has played a central role in information sharing in physics, mathematics, and r

...e defects could be major contributors to the neurodegenerative cascade, as has been reported in several neurodegenerative disorders. Drugs targeting the r

...ws that, although mitochondrial contribution to the pathogenesis of cancer has historically tended to be neglected, it is now evident that reprogrammed mi

|abstract=The [[International System of Units]], the SI, has been used around the world as the preferred system of units, the basic lang |?Has title=Reference

|abstract=The SciELO Program is setting in motion a basic plan for the development an ...and publication process of articles is a central issue that SciELO Brazil has been promoting by minimizing the time to indexing journals, the publication

...ylogeography of cattle genetic variants has been extensively described and has informed the history of domestication. However, there remains a dearth of d

{{Abstract |abstract=[[Image:MITOEAGLE-logo.jpg|left|100px|link=http://www.mitoglobal.org/index.

{{Abstract ...e homogenates (Thom), and permeabilized tissue fibres (Pfi), each of which has its pros and cons. Here, different mt preparations from two mammalian exper

...sion in proximity to certain mammalian cells when grown in culture. Oxygen has a low diffusion rate through cell culture media, thus, as a result of norma

...hnological development, especially electron microscopy and nanotechnology, has made it possible to obtain new scientific evidence that not only supports t

...the relationship between mitochondrial degradation and energetic activity has not yet been considered. Here, we report that the stimulation of mitochondr

...that such a shuttle operates similarly to the malate-aspartate shuttle; it has also been proposed that the two shuttles are necessarily interconnected in

...d, from both green and dark-grown plant materials. Only recently, however, has the method been applied to animal cells and tissues to supplant previous pr

{{Abstract ...tions, of which the very small cancer stem cell population is the one that has the growth and metastatic potential of the tumour. The other neoplastic cel

...on, from Tunisia, by performing complete mtDNA sequencing. This population has a mixed Eurasian/sub-Saharan mtDNA gene pool, which could potentially facil

...ses involved in production, distribution and removal. Substantial progress has been made exploring the formation and scavenging of H2O2, whereas little is

|abstract=19th Beijing Conference and Exhibition on Instrumental Analysis, Beijing, C :::: Oroboros participation was supported by the project NextGen-O2k which has received funding from the European Union’s Horizon 2020 research and inno

...ochrome c (Cyt c) release as a signal for programmed cell death. Complex I has been shown to generate reactive oxygen species (ROS), with key roles identi

{{Abstract |abstract=[[Image:MITOEAGLE-logo.jpg|left|100px|link=http://www.mitoglobal.org/index.

{{Abstract ...has been long utilised for the study of Ca²⁺ signaling [1]. It has been also engineered to induce its specific targeting to various cell regio

...uring the last 60-100 years the life style, at least in the Western world, has changed enormously. This became obvious with an increase in caloric intake,

...of the strongest aging theories proposed to date. The free radical theory has been expanded to the oxidative stress theory, in which mitochondria play a

...d death processes. Over the last decades, the 4,1-benzothiazepine CGP37157 has been the only available blocker of the mitochondrial sodium/calcium exchang

...ed as occurs in particular illnesses and injuries. Like a phoenix, lactate has risen to major importance in 21st century biology.

|abstract=Thomas Jefferson once observed, “I know of no safe depository of the ulti ...ughly 200 years since Jefferson made those pragmatic observations, science has provided incalculable knowledge and innovative tools that have improved peo

...in contradiction with empirical evidence, the diversity-stability paradox has survived the test of time for over 40+ years. In this paper we first show t

...lipotoxin accumulation in obesity. Experience from studies on xenobiotics has provided important insights into the regulation of hepatic mitochondria. In

|abstract=Purpose: Leber's hereditary optic neuropathy (LHON) is a genetic disease of ...r cell death. The conversion from the LHON carrier to the affected patient has been clinically characterized, but the pathophysiology is just beginning to

|abstract=Background ...yer in apoptosis and necrosis. Nitrite, a cellular nitric oxide reservoir, has a recognized role in cardiovascular protection, through still unclear mecha

...a. Cho-mediated elevation in mitochondrial PE is dependent on Vps39, which has been recently implicated in PE trafficking to the mitochondria. Accordingly

{{Abstract |abstract=Excess fructose consumption has been shown to mediate mitochondrial

{{Abstract ...cle, although recent reports have challenged this view. Previously our lab has demonstrated that directly targeting mitochondrial oxidative stress and ene

...ase in oxygen flux was observed following reoxygenation, a phenomenon that has been coined "oxidative burst". The amplitude of this "oxidative burst" was

|abstract=Brown adipose tissue (BAT) mitochondria are distinct from their counterpart ...for obesity and the metabolic abnormalities it incurs. Subsequently, there has been heightened interest in quantifying BAT function and more specifically,

...primary cells needed for bioenergetic analysis. This technical limitation has been overcome by combining the specificity of the magnetic bead isolation t

...ve stress has been implicated in pregnancy complications and previous work has shown that selenium can protect trophoblast mitochondria from oxidative str

...of the neurodegeneration observed in diabetic neuropathy. Our recent work has shown that mitochondrial dysfunction occurs in dorsal root ganglia (DRG) se

...been associated with numerous pathological conditions. In recent years it has become increasingly clear that oxidative and reductive modifications are co

{{Abstract ...mitochondrial evolution in a wide variety of species including humans and has the potential to provide a cohesive picture of the underlying mechanisms of

...ulture and strong opposition by some journal publishers [1]. The landscape has evolved rapidly in other fields in recent years, however, thanks to the lau

...nxiety and psychosis, while the inhibition of NOS and/or guanylate cyclase has been associated with an antidepressant response. This action of MB may cont

{{Abstract |abstract=Authors: [[Gama Perez Pau]]<br><br>

...thma. Montelukast, a robust antagonist of cysteinyl leukotriene receptors, has been widely applied for the therapies of bronchial asthma. However, the eff

...modality for various diseases involving mitochondrial dysfunction, but it has never been tested for sepsis.

{{Abstract ...and that the market demand for such solutions has reached a level where it has become viable for industry to invest in the development of commercial solut

...release from phosphocreatine hydrolysis in exercising CK-deficient muscle has been postulated to contribute to the lower fatigueability in skeletal muscl

|abstract= TRANSMIT Mid-Term Review Meeting, Bologna, Italy, 2018 This project has received funding from the European Union's Horizon 2020 research and innova

...ted in multiple cancers and, as with HSP90, evidence of addiction to TRAP1 has been observed. In this review, we summarize what is currently known about t

...rase and 2,4 dienoyl-CoA reductase). This review covers the knowledge that has been gained from these mouse models in terms of understanding both single-g

...e-site tyrosine (Tyr244) and that the neutral radical form of this residue has a more general role in the CcO mechanism than thought previously. This arti

...e in clinical trials. However, development of efficient personalized drugs has proved challenging and the combination with other strategies such as chemoc

{{Abstract ...a part in the skeletal muscle wasting seen with DOX treatment. Recent work has shown that exercise may help protect against this oxidative environment, th

...nnel blocker paxilline. In conclusion, these results suggest that luteolin has cardioprotective effects, at least in part, through the activation of the m

...mitochondrial deficiency with brain-specific manifestations. This proposal has been supported by recent mitochondrial DNA (mtDNA) analyses identifying bot

== Abstract == ...s (i) to compare the fitness and health status of a group of subjects that has been physically active for at least 6 years with an age and sex matched gro

|abstract= analytica China, Shanghai, China, 2024 :::: Since its debut in 2002, analytic China has become one of the biggest trade fairs in China. The exhibition portfolio fo

...-types, pulled away from the world of real things. The new SI (2019-05-20) has completed this total abstraction of units, from the previous necessity to n

...hain’ (ETC) is a misnomer. Understanding mitochondrial respiratory control has suffered greatly from this inappropriate terminology, although textbooks us

...hnology to replicate and maintain a physiological O2 environment in vitro, has hindered addressing this issue thus far. In this review, we aim to address

...gnosis, prognosis, and treatment. The study of mitochondrial bioenergetics has become critical in understanding the pathophysiology and treatment of compl

...es in metabolic rate or mitochondrial function. Malnutrition in early life has been linked to an increased likelihood to develop and an exacerbation of me

{{Abstract ...ricardium, most of which locates around the coronary artery. Recently, EAT has shown to be accumulated in coronary artery disease (CAD). However, the role

...ng time. Recently a new method based on mitochondria-targeted antioxidants has become the focus of interest. Here we review the current status of results

...ofiles. ''Juglans regia'', or common walnut, is a very resilient tree that has inhabited our planet for thousands of years. Many studies correlate walnut

...tween the tallest and shortest populations was 19-20 cm a century ago, and has remained the same for women and increased for men a century later despite s ...ribati where height has increased less than the worldwide median while BMI has increased a great deal.

{{Abstract ...except for the differences in their metabolism of citric acid. Recently it has been shown that alterations in metabolic activities of human prostate LNCaP

{{Abstract ...I will show that the topology of pores and protocells (and even the Earth) has been preserved in the structure of prokaryotic cells, where reversible flux

...roblem besetting people's daily life. Over the years, increasing attention has been paid to the study of anti-fatigue peptides. Several animal models have

...into three sub-classes, A, B and C, whose order of emergence in evolution has been controversial. Here we have analyzed recent structural and functional

{{Abstract ...from fatty acid oxidation and towards glucose uptake has been observed and has been proposed to represent an adaptive bioenergetic mechanism. We developed

...enhance sprint performance in humans. Although currently controversial, it has been reported that antioxidant ingestion during training may jeopardize som

{{Abstract ...ly also therapies receives a lot of attention in developed countries, this has not been the case in Africa. We have approached the identification and char

{{Abstract |abstract=[[File:Pesta_d.jpg‎|right|150px|Dominik Pesta]]

...iseases such as Parkinson’s disease (PD) and multiple sclerosis (MS). This has led to multiple attempts to use CoQ10 supplementation as a treatment or pre

{{Abstract |abstract=[[Image:MITOEAGLE-logo.jpg|left|100px|link=http://www.mitoglobal.org/index.

...mmed activities are now recognized as hallmarks of cancer, and recent work has uncovered remarkable flexibility in the specific pathways activated by tumo

|abstract=Gordon Research Seminar on Mitochondria & Chloroplasts, Ventura, West Dover :::: This conference has been withdrawn from the 2020 conference schedule

...these organelles important therapeutic targets. Mitochondrial dysfunction has been reported to occur in the setting of drug-induced toxicity in several t

...g selection in several species. Traditional testing of purifying selection has been based simply on ratios of nonsynonymous to synonymous mutations, witho

...great importance of cytoplasmic free Ca2+ in regulating cellular function has stimulated the development of several more-or-less calcium-selective sensor

...presents a major event that triggers a plethora of divergent responses and has therefore great potential to interfere with the experimental results and af

...dictable set of defects in all tissues. However, mitochondrial dysfunction has pleiotropic effects in multicellular organisms. Clearly, much about the bas

...e oxygen species (ROS) in the cellular response to cellular oxygen sensing has been controversial. Three papers in this issue of Cell Metabolism (Brunelle

...ed on the characteristics of the electromagnetic field. The new hypothesis has novel features which could be of biological interest.

...th hydrogenase in sequence and modular structure. The hydrogenase activity has been observed recently in complex I of higher plants. Based on these observ

...thors must disclose in their cover letter that a version of the manuscript has been deposited as a preprint and include any associated DOIs or accession n

...in, oxidative stress, or aberrant oncogene and tumor suppressor signaling, has been observed in a wide spectrum of human cancers. In this review, we summa

{{Abstract |abstract=Oral and oesophageal cancers are aggressive tumours associated with high mo

|abstract=The concept that cells die by a genetically regulated process has profound implications for human diseases in which too little or too much ce

...siological mechanisms of anoxia tolerance. However, relatively little work has been focused on what occurs beyond anoxia, and often the focus is a single

|abstract=Science is beautiful: it has truth, it has drama, it is full of wonder. The ''Mitchell's dream series'' is a vision of

...ing organ transplantation, whereas an RET-induced NAD+/NADH ratio decrease has been implicated in aging, age-related neurodegeneration, and cancer. In thi

...in part through its beneficial effects on mitochondrial function, and thus has been proposed as a possible anti-inflammatory therapy. We tested the hypoth

...for the generation of most of the cell's energy. Mitochondrial dysfunction has been implicated in cellular senescence in general and ovarian aging in part

{{Abstract |abstract=[[Image:MITOEAGLE-logo.jpg|left|100px|link=http://www.mitoglobal.org/index.

...of biological systems. While polyadenylation on mitochondrial transcripts has been suggested to be a two-step process required to complete translational

...l and the activity of other respiratory chain complexes. Hence, complex II has to be considered as an independent source of mitochondrial ROS in physiolog

...ific sub-mitochondrial localization or the dynamics of the interaction. It has been suggested that α-synuclein could only interact with ER-associated mit

...fect of reduced glomerular permeability for large molecules. Since hypoxia has been suggested as a common pathway to development of chronic kidney disease

...xidative phosphorylation. P53 originally identified as a tumor suppressor, has been demonstrated to be associated with energy metabolism. We proposed that

{{Abstract ...nce with mRNA transcription has a functional effect on translation. NDUFV2 has a pseudogene (NDUFV2P1), which is an attractive candidate for the regulatio

{{Abstract ...hown to be cardioprotective. Although the antioxidant effect of flavonoids has been long thought to be a crucial factor accounting for cellular cardioprot

{{Abstract |info=[http://ads-adea-2017.p.asnevents.com.au/days/2017-08-30/abstract/44893 Open Access]

...line in mammalian organisms. SIRT1, a NAD(+)-dependent deacetylase enzyme, has been suggested to mediate the adaptive responses to CR, leading to the spec

...to the high altitude regions, especially South America, Nepal, and India, has risen enormously in the past 10 years. Without special climbing ability the

...y. We thus report a novel function of BSF in flies and demonstrate that it has an important intra-mitochondrial role, which is essential for maintaining m

...obesity and diabetes. To date the measurement of bioenergetics parameters has required the use of cultured cells or extracted mitochondria with the corre

...future research suggestions for the prevention and treatment of DKD, which has important practical significance for the later treatment of patients with D

|abstract=[[File:BEC.png|25px|link=https://doi.org/10.26124/bec:2022-0019]] https://d ...nstruction of PI curves of unicellular organisms based on oxygen evolution has been difficult and time consuming due to the lack of sensitive instruments.

...uce ATP. We now show at the level of single oocytes, that supplied glucose has no effect on the redox potential of the oocyte. Pyruvate is a cytosolic oxi

{{Abstract |info=[https://academic.oup.com/jbcr/article-abstract/39/suppl_1/S176/4965623 Open Access]

|abstract=What brings the Earth to life, and our own lives to an end? For decades, biology has been dominated by information – the power of genes. Yet in terms of infor

...scribe the synthesis of new CGP37157 analogs, where the benzene-fused ring has been replaced by a pyridine. On top of a better water solubility and lower

...ant metabolic phenotype in cancer cells for a long time. More recently, it has been shown that mitochondria in most tumors are not defective in their abil

|abstract=Researchers posted more preprints to the [[bioRxiv]] server in 2018 alone t The analysis also shows that the number of downloads from the site has topped 1 million per month. BioRxiv, which allows researchers in the life s

...in plasma was believed to be similar to water. Here we reveal that plasma has an additional ascorbate-dependent oxygen-reduction activity. Plasma experim

{{Abstract |abstract=[[Image:MITOEAGLE-logo.jpg|left|100px|link=http://www.mitoglobal.org/index.

...understood to significantly impact the phenotype of cultured cells in the abstract, in practise the importance of the above parameters does not appear to be w

|abstract= TRACT Training, Belfast, United Kingdom, 2018 This project has received funding from the European Union's Horizon 2020 research and innova

...ain as a flexible central axis of charged and polar residues, and probably has a leading role in the propagation of conformational changes, aided by coupl

...ed based on assessment of TUNEL staining and caspase activity. Recent work has also emerged linking alcohol-induced oxidative stress with apoptosis provid

...uple, proton pumping from the chemical catalysis. Although their influence has been clearly demonstrated experimentally, the underlying molecular mechanis

...and comprehensive view of heart high-energy phosphate metabolism. The goal has been to provide a rational view for the functions of phosphocreatine, creat

|abstract=The study of mitochondria during the last years has revealed that this organelle plays an important role in the development and

...o height-age has been suggested for such populations; however its validity has not been demonstrated.

...active oxygen species (ROS) generated in this organelle. Evidence for this has been obtained from studies comparing the long-lived naked mole rat to labor

...ur primarily through facilitated metabolite diffusion, but recent analysis has questioned the importance of this process under normal physiological condit

...a possible solution for this paradox, we hypothesize that the CBF response has evolved to safeguard brain function in situations of moderate pathophysiolo

...oximate non-verbal system for representing and comparing numerosities that has no upper limit and for which accuracy is dependent on the numerical ratio. ...ike shape, size and color, is a basic property of our perceptual world. It has long been recognized that adults, infants and non-human animals can instant

...he membrane to the site of fumarate reduction in the hydrophilic subunit A has been proposed. By combining the results from site-directed mutagenesis, fun

{{Abstract ...opment, fitness and viability. The effect of subtle mitonuclear mismatches has received less attention, especially when subject to mild physiological stre

|abstract=::: <small>Version 2 ('''v2''') '''2022-05-09''' [https://wiki.oroboros.at/ [[File:Baglivo 2022 MitoFit QC graphical-abstract.png|right|300px|Graphical abstract]]

|abstract=46th annual congres of the International Society of Oncology and Biomarkers :::: The 46th ISOBM Congress has the aim to bring together participants active in all fields of basic and cl

...ortant for NADPH production, lipogenesis and glutamine metabolism, but ME2 has a more profound effect. Through the inhibition of malic enzymes, p53 regula

|abstract=63rd Annual Meeting of the Biophysical Society, Baltimore, Maryland USA, 20 ...chondrial topics. The Bioenergetics, Mitochondria, and Metabolism Subgroup has its two symposia on the first day of the meeting, March 2nd, and these two

...lar across the major journals in our specialty (appendix). Our institution has no dedicated funds to cover publication fees, and we were faced with either

...c table by Russian chemist Dimitri Ivanovich Mendeleev (1834–1907). The UN has designated 2019 the International Year of the Periodic Table of Chemical El

|abstract='''Mitochondrial Medicine 2016, Seattle, WA, USA.''' The [[United Mitochondrial Disease Foundation]] Symposium has been recognized by many researchers, scientists, and families as THE sympos

...ascular disease, diabetes, neurodegenerative disease, and cancer. Research has shown positive results in subjects supplemented with CoQ10, especially in r

...xygen consumption and activity of dehydrogenases in rat liver mitochondria has been studied. The addition of hypoxen to mitochondria caused a reduction of

{{Abstract |abstract=[[Image:MITOEAGLE-logo.jpg|left|100px|link=http://www.mitoglobal.org/index.

...ith a rise in the proportion of the population who live in cities1,2. This has led to a widely reported view that urbanization is one of the most importan

{{Abstract ...nstruction of PI curves of unicellular organisms based on oxygen evolution has been difficult and time consuming due to the lack of sensitive instruments.

...function and biogenesis. However, a causal relationship in skeletal muscle has not been investigated. We hypothesized that potential effects of ''in vivo'

...antly inhibited by 80% with 150μM 3BrPA. These results indicate that 3BrPA has the ability to uncouple the ATP hydrolysis from the calcium transport activ

{{Abstract ...gical process through which new blood vessels form from pre-existing ones, has not been addressed. Here we show that Opa1 is a crucial component of the an

...sults obtained with etomoxir and bromopalmitate treatment indicate that PA has to be oxidized to raise ROS production. A partial inhibition of superoxide

...olecular mechanism of complex I is central to the metabolism of cells, but has yet to be fully characterized. The last two years have seen steady progress

...ewy body inclusions. The contribution of mtDNA variants to PD pathogenesis has long been debated and is still not clearly answered. Cytoplasmic hybrid (cy

...showing the impact of the translocator protein (TSPO) over mtPTP activity has prompted several studies exploring the effect of TSPO ligands, including et

|abstract=It has recently been reported from several laboratories that mitochondrial DPN is

|abstract=55^th ESCI meeting, Virtual, 2021 :::: Oroboros participation was supported by the project NextGen-O2k which has received funding from the European Union’s Horizon 2020 research and inno

|abstract= Second retreat of the Daniel Swarovski Research Laboratory (DSL), Innsbruc ...LF|Luiz F Garcia-Souza]]: Short-term acclimatization to moderate altitude has no influence on mitochondrial respiration in peripheral blood mononuclear c

...cursor nicotinamide mononucleotide (NMN) ''in vivo'', indicating that CD38 has a key role in the modulation of NAD-replacement therapy for aging and metab

...gs. Owing to its great efficacy and lack of adverse effects, H₂ has potential for clinical applications for many diseases.

|abstract=The international standardizing organizations—AOAC International, has been prepared and agreed upon in the light of comments received following

...related pathologies. Mitochondrial function in brown adipose tissue (BAT) has been classically assessed by measuring either the levels/activity of mitoch

|abstract= 4th edition Metabolism & Cancer, Virtual, 2021 :::: Supported by project NextGen-O2k which has received funding from the European Union’s Horizon 2020 research and inno

|abstract='''FAT4BRAIN Online Workshop: Brain energy metabolism in emotion and cognit This project has received funding from the European Union's Horizon 2020 research and innova

{{Abstract |abstract=[[Image:MITOEAGLE-logo.jpg|left|100px|link=http://www.mitoglobal.org/index.

{{Abstract ...its assembly role. Thus, it would be of interest to determine whether SHY1 has other functions besides being a chaperonin.

{{Abstract ...e.at/scholar_url?url=http://www.jurology.com/article/S0022-5347(18)39647-2/abstract&hl=de&sa=X&scisig=AAGBfm26aGmfc4ijuNuYr28XvFDdqSnfkQ&nossl=1&oi=scholaralrt

|abstract=[[File:BEC.png|25px|link=https://doi.org/10.26124/bec:2022-0013]] https://d [[File:BEC Kinase graphical abstract.jpg|right|250px]]

...e vast majority of research on psychological distress after trauma and CVD has focused on posttraumatic stress disorder (PTSD), even though posttraumatic

{{Abstract ...riction in a similar manner, yet how this affects mitochondrial metabolism has not been determined. We aim to explore these questions and incorporate a co

{{Abstract ...f-Hirschhorn syndrome. Research in predominantly opsithokont model systems has resulted in disparate roles of Letm1 such as a cation/proton antiporter, tr

...neurological manifestation, and the impairment of mitochondrial functions has been probed in the pathogenesis of a wide range of illnesses including neur

{{Abstract ...oisoi N, Chakrabarti L (2022) Exercise alters mitochondrial physiology and has age-specific impacts on the fitness and lifespan of ''D. melanogaster''. ''

|abstract=The preceding communication has presented evidence for the formation of a complex with a 1:1 ratio of cytoc

...scle cells. The aim of this preliminary study was to examine whether ApoA1 has similar effect on leukocyte cell respiration, as it does on mouse muscle mi == Abstract continued ==

{{Abstract ...bstrates as energy source, resulting in ability to survive even when mtDNA has been completely depleted. What more, site-direct mutagenesis of yeast mtDNA

|abstract='''FAT4BRAIN 1st Online ESR Workshop, 2020''' This project has received funding from the European Union's Horizon 2020 research and innova

...cortical spreading depression. However, its lack of accuracy and precision has been the major obstacle toward more sophisticated clinical use of fNIRS. Th

...clusters in the hydrophilic domain of complex I from Thermus thermophilus has been determined with the use of x-ray crystallography. One binuclear and si

...(5, 15, and 33 °C). The southern subspecies of ''F. heteroclitus'', which has superior thermal and hypoxia tolerances compared to the northern subspecies

...scopy analysis and single particle image processing. Flux control analysis has demonstrated that Complexes I and III in mammalian mitochondria and Complex

...surement back to actual energy usage. Thus, the rate of oxygen consumption has become a measurement in its own right that is not necessarily synonymous wi

...between the detected optical signal and the underlying metabolic pathways has been lacking. We present a quantitative approach to detecting both function

{{Abstract |abstract=[[Image:MITOEAGLE-logo.jpg|left|100px|link=http://www.mitoglobal.org/index.

...ter being converted to TDGA-CoA. Using synthetic TDGA-CoA, this hypothesis has been confirmed. Assessing enzyme inhibition in an isolated rat liver mitoch

{{Abstract |abstract=[[Image:MITOEAGLE-logo.jpg|left|100px|link=http://www.mitoglobal.org/index.

...o accurately portray exactly how ambiguously the phrase "open peer review" has been used thus far, for the literature offers 22 distinct configurations of

...of Chlamydomonas without LHCSR maintains high rates of photosynthesis, but has reduced cell division rates in sinusoidal light conditions. PLoS One 12:1-2 ...ccumulation during the day in a sinusoidal light environment. This finding has direct implications for engineering strategies directed at increasing photo

...and tissues. It is therefore not surprising that mitochondrial dysfunction has emerged as a key factor in a myriad of diseases, including neurodegenerativ

|abstract=Succinate:quinone oxidoreductases (SQORs, EC 1.3.5.1) are enzymes that coup :::: has an entirely different meaning as the H⁺ in NADH + H⁺

{{Abstract ...gen uptake (VO2max). It is not known whether high intensity training (HIT) has the same effect on mitochondria and if these changes also occur in mitochon

...to fuel the TCA cycle. Rising evidence has shown that cellular metabolism has a direct effect on the regulation of immune cell functions. Thus, quiescent

...ingenuity of nature, and a book which is essential reading for anyone who has ever questioned the science behind the glories of everyday life.

{{Abstract ...Larsen FJ, Schiffer TA, Lundberg JO, Weitzberg E (2013) Human mitochondria has a unique response to ischemia-reperfusion injury compared to mitochondria f

|abstract=Peripheral arterial disease (PAD) is characterized by hemodynamically relev ...om high-resolution respirometry to values from CSA, mitochondrial function has been investigated.

...ition to cell viability testing. Selenium, an essential trace element that has been known to carry protecting property from heavy metals, was tested for i

{{Abstract |abstract=One in 500 people has a maternally inherited mitochondrial DNA (mtDNA) mutation, termed m.1555A>G

...parameter. The development of new light sources in UV and visible spectra has led to the development of small compact units applicable in clinical condit

...brain by reducing renal elimination of the toxin. However, this mechanism has never been formally demonstrated to date and is questioned by our previous

...at control levels. These results show that aestivating ''C. alboguttata'' has the capacity to independently regulate mitochondrial function in skeletal a ::::* ''Further details'': [[Gnaiger 2012 Abstract Bioblast-Gentle Science]]

|abstract='''FAT4BRAIN 4th Online ESR Workshop, 2022''' This project has received funding from the European Union's Horizon 2020 research and innova

...oxidative stress response in schizophrenia; however, most of the knowledge has been acquired from post-mortem brain analyses or from non-neural cells. Her

...g isolated rat liver mitochondria, we found that the F16-betulin conjugate has a surface-active effect on mitochondrial membranes, causing organelle aggre

...nswers crucial questions such as what are we all doing? How often? And how has it changed? Accompanying a major Wellcome exhibition on the same subject, "

...n energy expenditure. However, mitochondrial uncoupling in skeletal muscle has not extensively been studied in relation to adaptive thermogenesis in human ...CE:''' This study for the first time shows that in humans, skeletal muscle has the intrinsic capacity for cold induced adaptive thermogenesis via mitochon

{{Abstract ...on in muscles and insulin resistance. Recently, brown adipose tissue (BAT) has been suggested to play an important role in the pathogenesis of metabolic d

...or embryonic development and for survival through adulthood. Although much has been learned about the signaling pathways that are activated in hypoxic cel

...ochondrial membrane in eukaryotic organisms, no mitochondrial role for KMO has been described. In this study, KMO deficient ''Drosophila melanogaster'' we

...of the brain mitochondria during the early events of aging, a finding that has important consequences in the pathophysiology of brain senescence.

...athological conditions of critically ill patients, and no obvious evidence has yet been proposed to totally support liberal oxygen supplementation in any

...onments. Additionaly to the classical role in bioenergetics, mitochondrion has a decisive contribution to the oxidative stress, due to the electron leakag

...to improve circulating lipid profile in both rodents and humans. Our group has recently found strong evidence that 16:1n7 is an important positive modulat

...n a phospholipid membrane. This thermodynamic property of bound ubiquinone has important implications for the mechanism by which Complex I catalyzes proto

|abstract=Mito Xmas Meeting 2016. Mitochondrial function in health and disease. Innsb | [[Gnaiger 2016 Abstract Mito Xmas Meeting Innsbruck |The world as a laboratory: exploring mitochond

|abstract=1st Myocardial Function Symposium: “Targets in cardiometabolic disease” :::: The meeting has been established to increase scientific exchange and to foster collaboratio

...de caused by the addition of succinate to isolated mitochondria has been demonstrated. The material so reduced exhibits kinetic respon The nature of the reduction product has been examined in heart, liver, and guinea pig kidney mitochondria

...ysiological player. A number of vertebrate and invertebrate disease models has recently been established to circumvent the lack of human tissues, and thes

...cused on mitochondrial ATP production and transfer in failing hearts, less has been focused on the nonfailing hypertensive heart. Here, energetic complica * ''Further details'': [[Gnaiger 2012 Abstract Bioblast-Gentle Science]]

...basis of experiments carried out on isolated mitochondria. This conclusion has important implications for understanding the role of physiological or patho

...nces when a eukaryote with non-canonical code can be easily cultivated and has its whole genome and transcriptome sequenced. This is the case of ''Blastoc ...onclude that the dramatic alteration of the genetic code of ''B. nonstop'' has no significant repercussions on the metabolism of this flagellate.

...her is it known whether a single protease is responsible or the processing has inbuilt redundancy. Here, we show that incubation of human NK cells and pri

...lectron transport chain (ETC) and signal by reprogramming redox metabolism has only recently begun to be elucidated. Recent Advances: In contrast to the n

|abstract=Objective: To provide a critical review of recently published literature on ...performance criteria, and "matrix effect." Proficiency testing performance has been related to length of PT experience, test environment and volume, insti

{{Abstract |abstract=[[Image:MITOEAGLE-logo.jpg|left|100px|link=http://www.mitoglobal.org/index.

...ed, especially when dilute TPP+ is used. This type of calibration equation has been obtained experimentally by other authors, and is very useful from a pr

...d, suggesting oxidative stress reduction. Therefore, BMMNC transplantation has a positive effect on hepatic mitochondrial bioenergetics of cholestatic rat

|abstract=The ''p''-value has been debated exorbitantly in the last decades, experiencing fierce critique

{{Abstract ...tion for establishing new standards in functional mitochondrial diagnosis. Abstract Mitochondrial Medicine Chicago.

...e nineteenth century the importance of mitochondria in cellular physiology has been growing steadily. Not only the organelle harbors the main systems for

{{Abstract |abstract=[[Image:MITOEAGLE-logo.jpg|left|100px|link=http://www.mitoglobal.org/index.

...neural outputs are regulated. However, recent progress in neurophysiology has clarified that there are hypoxia-sensors not only in the periphery but also

{{Abstract |abstract=[[Image:MITOEAGLE-logo.jpg|left|100px|link=http://www.mitoglobal.org/index.

...of reduced GNMT on metabolic reprogramming before the manifestation of HCC has not been investigated in detail. Herein, we used ²H/<sup>13</sup

...skeleton is very capable of adapting to changes in weight, the mechanostat has limits. At the limits, extreme deviations from normal weight and body compo

|abstract=World Summit on Diabetes, Virtual, 2021 :::: Oroboros participation was supported by the project NextGen-O2k which has received funding from the European Union’s Horizon 2020 research and inno

...preservation and mitochondria are a key target for injury. Our laboratory has demonstrated that cold storage of renal cells and rat kidneys leads to incr

{{Abstract |abstract=Defects in the mitochondrial respiratory system are often associated with m

|abstract='''Long Night of Research 2020: The diagnostic bioenergetic report – a mi :::: Oroboros participation was supported by the project NextGen-O2k which has received funding from the European Union’s Horizon 2020 research and inno

{{Abstract |abstract=[[Image:MITOEAGLE-logo.jpg|left|100px|link=http://www.mitoglobal.org/index.

{{Abstract ...nsiderable controversy regarding these concepts, as mitochondrial function has traditionally been assessed in the presence of saturating substrates (ADP a

...the manifestation of the associated illnesses. During the past decades, it has become clear that, at the cellular level, mitochondria function as more tha

...l structure of the trypanosomal alternative oxidase at 2.85 Å (1 Å=0.1 nm) has revealed salient structural features necessary for its function. In the pre

...luding ischemic stroke, epilepsy, and Alzheimer's disease. Recent evidence has revealed that excitotoxic cell death is regulated by the B-cell lymphoma-2

...hway. We show that in flies, a pathway involving pink1, parkin and ref(2)P has a role in the maintenance of a viable pool of cellular mitochondria by prom

...ic transcription factor activated by diverse cytokines and growth factors, has been shown to exhibit an additional, nontranscriptional function in mitocho

{{Abstract ...sula, mostly from direct contact with humans. However, nature conservation has since indicated that these animals appear overweight, are lethargic and pre

{{Abstract ...eral animal groups, the relationship between selection and OXPHOS function has not been well characterized. Because organismal performance should be a fu

..., involving disproportionation of the Amplex® Red-derived radical species, has been proposed. The results indicate that peroxynitrite-derived radicals, bu

...and mutant membranes of ''Rhodobacter capsulatus''. A linear relationship has been found between these two parameters only when succinate was oxidized by

...state, metabolite concentrations, and other upstream signaling events and has important implications in cellular stress signaling, maintenance of stem ce

...ons on both a physiological and genetic level over 30 000-40 000 years. It has long been speculated that fetal growth restriction is caused by abnormal pl

...h of many people and represent a challenge for the society as a whole that has to deal with an ever-increasing number of affected individuals. Among commo

{{Abstract ...functionality. A pronounced tissue-specificity of mitochondrial membranes has been described, defined by the molecular composition of the fatty acyl side

...ivity remains the modus vivendi engrained in our genes and being sedentary has been the real intervention and collateral effect of modern societies. It is

{{Abstract |abstract=[[File:Karl-Tronstad.jpg|right|130px|Karl Johan Tronstad]]

{{Abstract ...onments. Additionaly to the classical role in bioenergetics, mitochondrion has a decisive contribution to the oxidative stress, due to the electron leakag

|abstract=Gradl L, Gradl P, Gnaiger E (2021) Titration-Injection microPump TIP2k manu |?Has title=Reference

...dent phase at the onset of contraction and an ADP-dependent phase after Mb has reached a steady state. In contrast to the accepted view, the initial intra

|abstract= ...culation. One of the biomedical problems involved in space flight, hypoxia has been the object of intense research in recent years. This most timely study

...e pool in isolated turnip and pea leaf mitochondria. A linear relationship has been found between these two parameters during succinate oxidation under bo

...ions proceed via formation of semiquinone radical intermediate species, it has been recently proven that this can be not completely true. Intensive voltam

{{Abstract ...ependent muscle loss and weakness. Specific autophagy inhibition in muscle has a major impact on muscle strength, ultimately affecting the lifespan of ani

|abstract= Mitochondrial Physiology ‐ from Organelle to Organism , Copenhagen, Denm :::: Deadline for poster presentation abstract: August 8, 2019.

...uced superoxide generation. Altogether, our study results indicate that CQ has a deleterious impact on cardiac mitochondrial bioenergetics which in turn s

|abstract=# Succinic dehydrogenase has been isolated from beef heart mitochondria as a soluble protein # The QO2, has been measured as 20,000 and the turnover number as 3000 under the

...d DPN by succinate catalyzed by submitochondrial particles from beef heart has been studied.

|abstract=A highly active DPNH-cytochrome c reductase has been isolated from beef-heart mitochondria. The best preparations of the en

...organelle and its role in several types of cancers and other disorders. It has been found that mitochondria-encoded proteins, mitochondrial DNA and even R

...ly) (''p'' < .05). In summary, we report for the first time that Actovegin has a marked effect on mitochondrial oxidative function in human skeletal muscl

...trochemical reduction of coenzyme CoQ(10) and CoQ(0) on glassy carbon (GC) has been investigated in mixed solvent containing 80 vol.% acetic acid and 20 v

{{Abstract |abstract=[[Image:MITOEAGLE-logo.jpg|left|100px|link=http://www.mitoglobal.org/index.

{{Abstract |info=[http://www.fasebj.org/content/31/1_Supplement/839.4.abstract?sid=820d2ccd-58bb-4de1-b6ca-d190cf29c00e Open Access]

...X-ray structural solution of members of the complex II family of proteins has provided important insights into their function. One feature of the complex

|abstract= AlgaEurope 2020, Virtual Event, 2020, NextGen-O2k :::: Oroboros participation was supported by the project NextGen-O2k which has received funding from the European Union’s Horizon 2020 research and inno

|abstract='''FAT4BRAIN ESR Workshop, 2023''' This project has received funding from the European Union's Horizon 2020 research and innova

|abstract=There has been, and continues to be, widespread concern about the so‐called reprodu :::: ''J Physiol'' also has a long‐standing and continuing tradition of publishing very detailed Meth

|abstract= Fourth International Congress - Challenges in Redox Biology, Belgrade, Ser ...o everyone who creates this scientific challenge. The organizing committee has one more challenge, to present Belgrade and Serbia as good hosts, and to ga

...appropriate way of cell banking. However, mitochondrial-mediated apoptosis has been reported after cryopreservation and little is known on the involved mo

...elements of Margulis' later endosymbiotic theory. As the holobiont concept has become an important guiding concept for organizing research, labeling confe ::::* “Holobiont” is a concept that has been an attractor for several ideas, and researchers have independently con

...hondrial energy metabolism and redox homeostasis. However, this hypothesis has not been explored. The present study demonstrates for the first time that,

...erization of CPT I and CPT II in human muscle homogenates. In addition, it has been shown that L-AC can be used for the study of metabolic consequences of

...s of fertilizing potential ''in vivo'' and ''in vitro''. Analogous to what has been observed in somatic cells, mitochondria are likely the major sources o

...n associated with a pathologic condition called manganism. Furthermore, Mn has been reported to affect lipid metabolism by mechanisms which have yet to be

|abstract=<big>'''Journal publication 2021-12-08 in [[Vernerova 2021 Biomedicines |'' ...:Vernerova 2021 Mitofit PLT - graphical abstract.png|right|300px|Graphical abstract]] Multiple non-aggregatory functions of human platelets (PLT) are widely ac

...dritic cell maturation and function in order to evade host immunity, which has been demonstrated in colorectal cancer.

...shown here in the structure of the bovine F(1)-c-ring complex, the c-ring has eight c-subunits. As the sequences of c-subunits are identical throughout a

|abstract=19th Chinese Biophysics congress, Anhui Province, China, 2021 :::: Oroboros participation was supported by the project NextGen-O2k which has received funding from the European Union’s Horizon 2020 research and inno

|abstract=The aromatic amino acid hydroxylases (AAHs); phenylalanine hydroxylase (PAH ...and hypoxia induced diseases, such as altitude sickness and sleep apnoea, has been suggested.

{{Abstract |abstract=Early-life exposure to stressful experiences has been described as a predisposing factor to develop psychopathologies includ

...However, isolation of sufficient amounts of mitochondria from cell culture has proven to be notoriously difficult due to small sample size. Thus, we have

|abstract=The academic publishing industry earns high profits and shapes how we under ::::* Like 14 other countries, the Research Council of Norway has also approved Plan S. Under this plan, all research supported through funds

...majority display neurologic symptoms and neurodegeneration. Only recently has a role emerged for mitochondrial dysfunction in the pathophysiology of LSDs

{{Abstract |abstract=Recently nitrite has been shown to protect various organs from ischemia-reperfusion injury, in p

...oint for more investigations since stress is a constant factor in life and has become one of the most significant health problems in modern societies.

...he need for significant protein conformational changes. In recent years it has become possible to follow key partial reactions of the catalytic cycle in r

...p between aerobic exercise and mitochondrial function in diabetic patients has yet to be investigated. We hypothesized that a long-term aerobic exercise i

...-10b, -212, -132, -495) were significantly altered. One of them (miR-132) has been reported to be highly inducible by growth factors and to be a key regu

...ften erroneously thought to occur instead of mitochondrial respiration and has been misinterpreted as evidence for damage to respiration instead of damage

{{Abstract |info=[http://www.fasebj.org/content/31/1_Supplement/839.22.abstract?sid=820d2ccd-58bb-4de1-b6ca-d190cf29c00e Open Access]

...d for large-scale high-resolution screening of human mtDNAs. This strategy has in the past been applied to mtDNA haplogroup V, which represents <5% of Eur

...drial respiration is a major source of reactive oxygen species in vivo, as has been shown in vitro, and that these species are produced even under low aer ...n conditions, making it likely that MnSOD plays a more important role than has been previously realized, in spite of its lower abundance.

...nostic parameter was sensitive to cryopreservation. Conclusion: This study has demonstrated for the first time that cryopreservation of primary immune cel ...cryopreservation can also affect cellular bioenergetics, but to date this has not been explored in isolated primary immune cells."

...it was estimated that the individual mitochondrion isolated from rat liver has a volume of 0.27 µm³, an inner membrane area of 6.5 µm<sup>2</

...e chains. Furthermore, Vitamin K2, which has an isoprenoid side chain, and has been proposed to be a mitochondrial electron carrier, had no efficacy on UQ

...terial pressure on RV dysfunction, although the underlying mechanism in RV has not been determined. Therefore, this study is aimed at evaluating sirtuin-3

|abstract=[[File:Dambrova 2022 graphical abstract.png|right|250px|Graphical abstract]] ...rition states often include measurements of different acylcarnitines. This has resulted in increased interest regarding the consequences of increased/decr

|abstract='''FAT4BRAIN 3rd Online ESR Workshop, 2022''' This project has received funding from the European Union's Horizon 2020 research and innova

...e saturation kinetics of NADH and succinate oxidation for Coenzyme Q (CoQ) has been re-investigated in pentane-extracted lyophilized beef heart mitochondr

...as a novel antitumor strategy. However, its mitochondrial homologue TRAP1 has not been implicated in cancer with conclusive mechanistic insights. Since u

...ter malate metabolism in astrocytes. We propose that malic enzyme in brain has an important role in the complete oxidation of anaplerotic compounds for en

...samples. However, confirmatory respiratory analysis on fresh human tissue has been hampered by multiple difficulties. Thus, few mitochondrial respiratory

...molecule increases H₂O₂ levels in ''L. amazonensis'' has not been elucidated. Here we investigated the source of H₂O<sub>

...its role in the cellular antiviral response, induction of oxidative stress has emerged as a common strategy employed by many viruses to promote their repl

...tionship between H₂O₂ production rates and longevity has not emerged. Concomitantly, novel insights into the mechanisms of reactive

{{Abstract |abstract=Reactive oxygen species (ROS) originating from mitochondria are perceived a

|abstract='''FAT4BRAIN 2nd Online ESR Workshop, 2021''' This project has received funding from the European Union's Horizon 2020 research and innova

...unclear. Mitochondria are an important source of ROS, and in one model it has been proposed that hypoxia increases the generation of ROS at complex III i

...tuations in MFN-2, as observed in response to physiological perturbations, has a functional consequence. Therefore, we have transiently transfected MFN-2

|abstract= Course in Cancer Metabolism, Bertinoro di Romagna, Italy, 2018 This project has received funding from the European Union's Horizon 2020 research and innova

|abstract=The achievements of scientific research are amazing. Science has grown from the occupation of a few dilettanti into a vibrant global industr

== Abstract == ...team sport athletes but for endurance athletes in general. A sport module has to be effective, time efficient and economically attractive. As a basis we

|abstract=Twenty-six years ago, in August 1991, I spent a couple of afternoons at Los ...om the rest of the scientific community, in an attempt to assert that what has been so successful and continues to grow ‘couldn’t possibly’ work in

...ons and their clusters are a thermodynamically nonequilibrium phase, which has been demonstrated in experiments with magnetic stirrer at different stirrin

...ivity, or the generation of side products. H₂-driven cofactor regeneration has the advantage of 100% atom efficiency and the use of H₂ as a cheap reduci

...slate these insights into actionable strategies to extend human healthspan has been limited. One of the major reasons for the existence of this barrier is

{{Abstract ...the decrease of pyruvate secretion by brewer’s yeasts during fermentation has long been desired in the alcohol beverage industry, rather little is known

...II, and the modulation of TBI induced NO levels in different brain regions has to be prospectively analyzed in more detail.

...besity and associated metabolic complications. Short-term cold acclimation has been shown to not only enhance BAT presence and activity in lean humans, bu

|abstract='''FAT4BRAIN Online Workshop: Central regulatory mechanisms of energy metab This project has received funding from the European Union's Horizon 2020 research and innova

...act=Over the years, the mitochondrial fatty acid β-oxidation (FAO) pathway has been characterised at the biochemical level as well as the molecular biolog

...To enable the use of RBE as food additive, a stabilized ethanolic extract has been produced. Here, we compare the vitamin E profiles of both extracts and

...y of English literary criticism. Revised twice since it first appeared, it has remained one of the most widely read and quoted works of literary analysis.

...e salts on dihydroorotate dehydrogenase (DHODH)-dependent respiration that has a key role in the ''de novo'' pyrimidine synthesis pathway. We also show th

|abstract= MitoGlobal This project has received funding from the European Union's Horizon 2020 research and innova

...To date, however, the oxidative capacity of this adipose tissue (AT) depot has not been characterized in humans.

...ce |»Bioblast link]] - ''Ginsparg was emphatic that a preprint, because it has a time stamp and is publicly available, plays a key role in establishing pr ...Preprint reference in Bioblast is directed to the journal reference in the abstract (with information on day of acceptance and day of journal publication, as f

...hat obesity is an evolutionary adaptation for surviving periods of famine, has dominated the thinking on this topic. Obesity researchers are often not awa

...apidly, whereby reasons for this decrease are unknown so far. Recently, it has been suggested that loss of tissue tension ''in vivo'' leads to apoptosis.

...lear DNA content compared with baseline. In this work we show that obesity has an opposing association with mitochondrial respiration in adipose- and live

...f many human diseases. To date, determination of oxidative phosphorylation has required fresh and live sample material and therefore also access to specia

|abstract=Medical and scientific advances are predicated on new knowledge that is rob ...es that pervade our current system of basic and preclinical research. This has been highlighted empirically in preclinical research by the inability to re

...eration and myocardial infarction. Although mitochondrial Ca(2+) transport has been characterized, and several molecules, including LETM1, have been ident

{{Abstract |abstract=[[Image:MITOEAGLE-logo.jpg|left|100px|link=http://www.mitoglobal.org/index.

{{Abstract |abstract=Our research has documented horizontal transfer of mitochondria in a mouse model of cancer f

...complex, coupled, many-body quantum systems, in which electronic coherence has recently been shown to survive for relatively long timescales, despite the

...in collaboration with the freely accessible preprint platform SSRN, which has been part of Elsevier since May, 2016. With this pilot, we are interested t ...re is a trial registration number. Our editor will check whether the trial has been registered prospectively and whether the authors mention ethical appro

...r (<0.05) in triploid salmon compared with diploid salmon. Triploid salmon has a higher fat deponation than diploid salmon. The amount of the carotenoid a

...that mitochondrial dysfunction may contribute to HD phenotype. Recent work has demonstrated that voluntary wheel running reduces hindlimb clasping in the

...failure, ''de novo'' lactate production in the brain has been observed and has led to a hypothesis of compromised brain metabolism during ALF. In contrast

{{Abstract |abstract=<big>'''Peter Hochachka lecture'''</big>

...pecies when compared at a common temperature. The northern subspecies also has greater mitochondrial respiratory capacity in the liver, although these dif

...rgely shared by the body's different tissues and systems and only recently has special attention been paid to the possible linkages among chronic periodon

{{Abstract ...embrane potential, respiration, matrix volume and Ca2+ ion homeostasis. It has been suggested that mitochondrial potassium channels participate in ischemi

...namics has been proposed as novel strategy for antidementia drugs. Dimebon has been shown to improve cognition in animal models and seems to be beneficial

...annel: the mitochondrial permeability transition pore (mPTP). mPTP opening has been implicated as a final cell death pathway in numerous diseases and ther

...l structure of the trypanosomal alternative oxidase at 2.85 Å (1 Å=0.1 nm) has revealed salient structural features necessary for its function. In the pre

{{Abstract |abstract=Erythropoietin (Epo) treatment has been shown to induce mitochondrial biogenesis in cardiac muscle along with

{{Abstract ...sity and related diseases, and the relevance of WAT mitochondrial function has been highlighted in the literature during the last decade [1,2,4]. Mitochon

...ive metabolism accommodating growth and productivity, respectively. miR-23 has previously been demonstrated to play a role in glutamate metabolism resulti

|abstract=This paper presents a microfabricated reservoir-type oxygen sensor, which c ...ane were used. This is the first report in which the fastest response time has been achieved for the oxygen sensor. The fabricated

{{Abstract ...ing through binding to Cyp-D and to protect the heart during IR injury. It has, however, off-target effects such as immunosuppression and multiple drug in

...istic principles underlying the proton pump. In addition to reviewing what has already been achieved in complex I modeling, we aim here to identify pressi

{{Abstract |abstract=[[Image:MITOEAGLE-logo.jpg|left|100px|link=http://www.mitoglobal.org/index.

|abstract=The 4th China Symposium on Neuro-Controlled Metabolism, Hangzhou city, Chin :::: Oroboros participation was supported by the project NextGen-O2k which has received funding from the European Union’s Horizon 2020 research and inno

{{Abstract ...expression pattern in normal and cancer cells. The potassium channel Kv1.3 has a multiple sub-cellular localization, including both in the plasma membrane

...t of electric potential (ΔΨ) and of proton concentration (ΔpH). The Δμ +H has a central role in the photosynthetic process, providing the energy source f

...subsarcolemmal (SSM) and interfibrillar (IFM). Dysfunction to cardiac SSM has been reported in murine models of type 2 diabetes mellitus; however, subpop

...tebrates. The mammalian COX4-2 gene is hypoxia responsive, and the protein has a disrupted ATP-binding site that confers kinetic properties on COX that di

|abstract=Trehalose is a disaccharide and fasting-mimetic that has been both canonized and vilified for its putative cardiometabolic and micro

...ormal ΔΨm in cancer cells remain unclear. Research on different cell types has shown that ΔΨm is regulated by various intracellular mechanisms such as b

|abstract=The study hypothesis is that administration of inhaled NO plus oxygen to su ...has been withdrawn stopped as a result of a safety concern, and no patient has had a serious adverse event related to NO.