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Additive effect of convergent NS-electron flow
#REDIRECT [[Additive effect of convergent electron flow]]

57 bytes (7 words) - 08:28, 28 March 2016

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NS e-input
...spiration. For more details, see: [[Additive effect of convergent electron flow]].

1 KB (149 words) - 18:49, 1 January 2021
Template:SUIT NS
...thway state |type N substrates]] & [[succinate]], with convergent electron flow in the NS-pathway for reconstitution of TCA cycle function.

216 bytes (27 words) - 15:52, 14 February 2019
Additive effect of convergent electron flow
...l>II). This condition of complete additivity, NS=N+S, would be obtained if electron channeling through supercomplex CI, CIII and CIV does not interact with the

3 KB (428 words) - 15:34, 31 January 2024
Talk:Electron-transfer-pathway state
...nate, S, and electron transfer through CII to the Q-junction, with further electron transfer through CIII and CIV to oxygen. Convergent electron flow from a combination of NADH-generating substrates (N) and succinate (S) has

2 KB (268 words) - 09:58, 3 June 2020
Q-junction
...ction]] and [[F-junction]] upstream, provides the rationale for defining [[Electron-transfer-pathway state]]s and [[categories of SUIT protocols]]. ...tron flow]] at the Q-junction, exerting an additive effect on flux, versus electron gaiting for separation of single N- and S-input pathways (upper panel: [[Gn

2 KB (291 words) - 19:31, 25 August 2023
NS-pathway control state
...dium. NS in combination exerts an [[additive effect of convergent electron flow]] in most types of mitochondria. |info=[[Electron-transfer-pathway state]], [[Gnaiger 2020 BEC MitoPathways]], [[Gnaiger_2009

4 KB (604 words) - 08:32, 25 November 2023
Template:Keywords: Q
::::» [[Convergent electron flow]] ::::» [[Reverse electron flow from CII to CI]]

2 KB (135 words) - 10:18, 3 April 2021
Spinelli 2021 Science
...batini DM (2021) Fumarate is a terminal electron acceptor in the mammalian electron transport chain. Science 374:1227-37. https://doi.org/10.1126/science.abi74 ...se the SDH complex under hypoxia. Thus, we delineate a circuit of electron flow in the mammalian ETC that maintains mitochondrial functions under oxygen li

2 KB (224 words) - 09:03, 2 April 2023
PGMS-pathway control state
::::» [[Additive effect of convergent electron flow]] ::::» [[Convergent electron flow]]

2 KB (284 words) - 18:29, 17 March 2022
PMS-pathway control state
...synthase). This documents an additive effect of convergent CI&II electron flow to the Q-junction, with consistent results obtained with permeabilized musc ::::» [[Additive effect of convergent electron flow]]

1 KB (193 words) - 18:30, 17 March 2022
Template:SUIT text D066
...inhibitors, ''e.g.'' oligomycin. [[Additive effect of convergent electron flow]] through [[N-pathway control state|NADH-]] and [[NS-pathway control state|

2 KB (220 words) - 12:55, 25 November 2020
GMS-pathway control state
...SRot (CII). This documents an additive effect of convergent CI&II electron flow to the Q-junction, with consistent results obtained with permeabilized musc ::::» [[Additive effect of convergent electron flow]]

3 KB (378 words) - 18:30, 17 March 2022
Gnaiger 2009 Int J Biochem Cell Biol
...r, respiration is limited artificially by supplying N- or S-substrates for electron input through either Complex I or II. High-resolution respirometry with min ...mitochondrial respiratory capacity by temperature in mouse heart: electron flow through the Q-junction in permeabilized fibers. Sci Rep 7:2840. - [[Lemieux

7 KB (975 words) - 13:46, 1 May 2024
SUIT-028
...to Q), NS''P'': Respiratory stimulation by convergent electron flow through Complexes I&II at the Q-junction, in the coupled sta | electron transfer-pathway (ET-pathway) capacity with type NS substrates, NS''E'

4 KB (574 words) - 16:13, 14 April 2020
Electron transfer pathway
|description=In the mitochondrial '''electron transfer pathway''' (ET pathway) electrons are transferred from externally » [[#Electron transfer pathway versus electron transport chain |'''MiPNet article''']]

5 KB (646 words) - 01:06, 31 December 2020
Lemieux 2017 Sci Rep
...mitochondrial respiratory capacity by temperature in mouse heart: electron flow through the Q-junction in permeabilized fibers. Sci Rep 7:2840. doi:10.1038 ...linked mt-matrix dehydrogenases and the phosphorylation system rather than electron transfer complexes as the primary drivers of thermal sensitivity at low tem

4 KB (595 words) - 09:34, 30 November 2023
SUIT-009 AmR ce-pce D019
...O2 flux declines dramatically. Pyruvate (P) supports the [[NADH Electron transfer-pathway state|NADH-pathway]] and thus the convergent NS-pathway wi ...the LEAK state, which prevents excessively high H2O2 flow.

5 KB (832 words) - 00:10, 13 April 2021
Makrecka-Kuka 2015 Biomolecules
...pacity, and were further diminished in uncoupled mitochondria respiring at electron transfer-pathway capacity. Simultaneous measurement of mitochondrial respir

4 KB (484 words) - 19:56, 7 January 2024
Chicco 2022 Abstract Bioblast
...fect on OXPHOS or ET capacity (''P'' or ''E'', respectively) of convergent electron-input into the Q-junction. Substrate-uncoupler-inhibitor titration (SUIT) p ...in SUIT protocols used to study the additive effect of convergent electron flow at the Q-junction.

4 KB (625 words) - 08:33, 28 July 2022
Talk:SUIT-029
...''e.g.'' oligomycin. Optionally, [[additive effect of convergent electron flow]] through [[N-pathway control state|NADH-]] and [[NS-pathway control state| ::::* [[SUIT-008]]: A protocol to evaluate NS-linked pathway in the OXPHOS and ET states.

5 KB (641 words) - 12:44, 25 November 2020
SUIT-009 AmR mt D021
...b>O2 production in the LEAK state. Pyruvate (P) supports [[NADH Electron transfer-pathway state|NADH-pathway (N)]], and usually in the presence of A ...ect, which would lead to a decrease in N-linked respiration and in reverse electron transfer-supported H2O2 flux ([[RET]]).

5 KB (681 words) - 00:11, 13 April 2021
Succinate pathway
...see [[Gnaiger 2009 Int J Biochem Cell Biol]]). The S-pathway describes the electron flux through [[Complex II]] (CII; see [[succinate dehydrogenase]], SDH) fro |info=[[Electron-transfer-pathway state]], [[Gnaiger 2020 BEC MitoPathways]], [[Gnaiger 2000

8 KB (1,053 words) - 08:04, 30 March 2023
Ramos-Filho 2015 PLoS One
...nsity interval training (HIIT) induces specific changes in respiration and electron leakage in the mitochondria of different rat skeletal muscles. PLoS One 10: ...strates. Unexpectedly, the HIIT protocol induced different respiration and electron leakage responses in different types of muscle.

3 KB (437 words) - 15:45, 13 November 2017
Electron-transfer-pathway state
...ondrial [[coupling-control state]]s. [[Coupling-control state]]s require [[Electron-transfer-pathway state|ET-pathway competent states]], including oxygen supp ...ways are stimulated by fuel substrates (CHNO) feeding electrons into the [[Electron transfer pathway]] at different levels of integration and in the presence o

15 KB (1,913 words) - 19:27, 25 August 2023
Respiratory state
...must be defined in terms of both, the [[coupling-control state]] and the [[electron-transfer-pathway state]]. ::::* [[OXPHOS]], [[LEAK respiration]], [[Electron transfer pathway|ET-pathway]] (''P, L, E'') - corrected for [[ROX]]. ''CCR'

3 KB (400 words) - 15:50, 15 August 2021
Kilbaugh 2015 Exp Neurol
...respiration 24h after focal TBI. These alterations in convergent electron flow though both complex I and II-driven respiration resulted in significantly l

4 KB (535 words) - 14:54, 13 November 2017
Bombicino 2016 Arch Biochem Biophys
...aldez LB (2016) Mitochondrial nitric oxide production supported by reverse electron transfer. Arch Biochem Biophys 607:8-19. ...t the inhibitory effect of rotenone on NO production is due to an electron flow inhibition and not to a direct action on mtNOS structure. NO production sus

2 KB (328 words) - 10:46, 24 June 2019
Palacka 2021 Int J Mol Sci
...ion can contribute to increased oxidative stress by triggering the reverse electron transport from the CoQ10 cycle (Q-junction) to CI. ...ty, as additional uncoupler titration is necessary to reach the maximum O2 flow at this state.

3 KB (457 words) - 22:56, 23 September 2023
Stepanova 2017 J Cereb Blood Flow Metab
...: Potential mechanism for brain ischemia-reperfusion injury. J Cereb Blood Flow Metab 37:3649-58. |journal=J Cereb Blood Flow Metab

2 KB (348 words) - 21:42, 13 April 2022
Stampley 2023 Physiol Rep
...pacities. There were exercise-induced increases in the tissue-level oxygen flow (IO2-tissue [pmol·s-1 ·mL blood-1 ]) for

2 KB (337 words) - 15:40, 20 June 2023
Shabalina 2013 Abstract IOC79
...physiological relevance, whereas an increased ROS production from forward electron transport may underlay the manifestations of premature aging observed in th

3 KB (378 words) - 16:01, 13 November 2017
Gnaiger 2017 Abstract MitoEAGLE Barcelona
...programming of OXPHOS-capacity. This would be obscured when considerig the electron transfer-pathway (Fig. 1) or ET-capacity as being primarily controlled by t ...rotocols starting with either PM or GM (SUIT 1 and 2), convergent electron flow at the Q-junction in the NADH&succinate (NS) pathway, and azide titrations

7 KB (927 words) - 18:53, 10 January 2022
Irving 2022 Abstract Bioblast
...Reductions in nitric oxide (NO) bioavailability can reduce cerebral blood flow, promote the deposition of β-amyloid (Aβ), and contribute to mitochondria ...carbonyl cyanide m-chlorophenyl hydrazine (CCCP) (0.5 µM/step) to achieve NS-linked ET capacity (NS''E''). Next, we titrated rotenone (0.5 µM) to m

6 KB (904 words) - 08:41, 28 July 2022
Zhang 2022 Int J Mol Sci
...omplex II (CII) convergent electron flow to the Q-junction and to identify electron transport system (ETS) alterations in fresh PCa tissue. The results documen |keywords=TCA cycle, Citrate, Electron transport system, Respiratory analysis

2 KB (313 words) - 18:32, 3 November 2022
Gnaiger 2015 Abstract MiPschool Cape Town 2015
|title=The functional design of the electron transfer system (ETS) and mitochondrial respiratory control. ...(permeabilized cells and tissues, homogenates, isolated mitochondria). The electron transfer-pathway (ET) capacity of mt-preparations depends on (i) substrate

7 KB (953 words) - 18:33, 10 January 2022
Lemieux 2019 bioRxiv
...xcess Complex IV capacity above NS-pathway capacity. In contrast, electron flow reached only 60% when supported by succinate alone through Complexes II, II

3 KB (477 words) - 11:08, 27 November 2021
Holody 2019 MiP2019
...and female offspring were collected at postnatal days (PD) 1, 14, and 28. Electron transport system and fatty acid β-oxidation capacities were assessed in pe ...w through complexes I and II; P=0.06), and the succinate-pathway (electron flow through complex II; P=0.02) were reduced in ID male pups only, while comple

4 KB (583 words) - 13:01, 17 September 2019
OXPHOS capacity
...are protons pumped out of the matrix phase to the positive P-phase. Proton flow to the negative matrix phase (H+in) drives the phosph ...n flux]] in state ''P'', ''J''O2''P'' or as [[oxygen flow]] in state ''P'', ''I''O2''P''. If these conditions a

6 KB (808 words) - 01:02, 31 December 2020
Ryan 2016 J Mol Cell Cardiol
...ate an important link between ischemic tissue bioenergetics and limb blood flow and indicate that the mitochondria may be a pharmaceutical target for thera

2 KB (296 words) - 15:17, 28 March 2018
Donnelly 2024 Redox Biol
...s. Our results suggest that by regulating calcium uptake the mitochondrial electron transfer system is a hub for coordinating cellular adaption under functiona

3 KB (366 words) - 13:55, 1 May 2024
Pesta 2012 Methods Mol Biol
...the Q-cycle, providing diagnostic information on specific branches of the Electron transfer pathway. Oxygen levels are maintained above air saturation in prot ...esence of a cocktail of Complex I-linked substrates (glutamate&malate) and electron transferring flavoprotein-linked substrate (octanoylcarnitine). It is sugge

8 KB (1,056 words) - 10:11, 23 May 2022
Cardoso 2022 Q10 Hamburg
...te ― and transfer electrons to Q followed by oxidation via Complex III and electron transfer to Complex IV and O2. Respiratory rates are modulated b ...d, when the phosphorylation system does not limit respiration and electron flow exerts a maximum pull effect downstream of the Q-junction.

4 KB (580 words) - 18:34, 5 May 2022
Nemec 2017 MiP2017
...on octanoylcarnitine+malate+pyruvate+succinate fueling convergent electron flow from fatty acid oxidation, NADH-linked pathway and succinate (FNS''P''

5 KB (623 words) - 11:22, 17 January 2019
Boushel 2012 Am J Physiol Regul Integr Comp Physiol
...bition of Indo. This metabolic effect in concert with a reduction of blood flow likely accounts for ''in-vivo'' changes in muscle O2 consumption

2 KB (347 words) - 17:00, 9 November 2017
Munro 2013 Aging Cell
...al respiration tested, including forward, reverse, and convergent electron flow. Alternative oxidase activity does not seem to explain these differences. H

3 KB (376 words) - 16:44, 21 November 2018
Komlodi 2021 MitoFit Q
...ystem, reflect the balance between (''1'') reducing capacities of electron flow from fuel substrates converging at the Q-junction, (''2'') oxidative capaci ...upercomplex organization. The direct proportionality of CoQ2 reduction and electron input capacities through the CI-Q-CIII and CII-Q-CIII segments suggests tha

5 KB (767 words) - 08:41, 8 January 2023
Gnaiger 2017 MiPschool C1
...mitochondrial respiratory capacity by temperature in mouse heart: electron flow through the Q-junction in permeabilized fibers. Sci Rep 7:2840. - [[Lemieux

2 KB (205 words) - 12:34, 3 November 2018
Komlodi 2021 BEC Q
...ystem, reflect the balance between (''1'') reducing capacities of electron flow from fuel substrates converging at the Q-junction, (''2'') oxidative capaci ...organization. The direct proportionality of CoQ2 reduction and electron input capacities through the CI-Q-CIII and CII-Q-CIII segments suggests tha

6 KB (810 words) - 16:37, 21 January 2024
Gnaiger 2018 MiP2018
...β-oxidation, generating (enzyme-bound) FADH2, the substrate of electron transferring flavoprotein (CETF). Succinate does not belong to the type 4 s ...mitochondrial respiratory capacity by temperature in mouse heart: electron flow through the Q-junction in permeabilized fibers. Sci Rep 7:2840. - [[Lemieux

6 KB (827 words) - 11:51, 3 November 2018
Lemieux 2017 bioRxiv 103457
...mitochondrial respiratory capacity by temperature in mouse heart: electron flow through the Q-junction in permeabilized fibers. Sci Rep 7:2840, DOI:10.1038

4 KB (513 words) - 18:56, 22 May 2019
Duicu 2012 Rev Med Chir Soc Med Nat Iasi
...activating convergent electron flow from CI+II into the Q junction of the electron transport system (ET-pathway); CII_P, 302.26 +/- 50.16 (CII dependent OXPHO

2 KB (325 words) - 11:42, 23 January 2019
Van Schaardenburgh 2017 J Transl Med
...ion improves walking performance. Exercise does not usually increase blood flow, but seems to increase muscle mitochondrial enzyme activities. Although exe ...F)P (p = 0.0005), complex I + complex II (CI + CII + ETF)P (p = 0.011) and electron transfer-pathway capacity (CI + CII + ETF)E (p = 0.021) and OXPHOS coupling

3 KB (425 words) - 09:57, 11 June 2018
Talk:Chicco 2022 MitoFit
...-pathway flux"? - The NS-pathway is defined as the pathway with convergent electron input into the Q-junction from N- and S-substrates. N+S is the algebraic su ...nd Figure 1: 'A simplistic view of this convergence predicts that electron flow from N-pathway substrates sum with succinate (S-pathway) electrons to accou

10 KB (1,472 words) - 12:58, 26 May 2022
Template:MitoPediaAlert2024
...is simultaneous electron transfer from FAO into the Q-junction through the electron transferring flavoprotein dehydrogenase complex (CETFDH) and Complex I. 

6 KB (800 words) - 08:49, 6 May 2024
Christensen 2016 J Appl Physiol (1985)
...es for ETFP, electron transport system capacity (ET-pathway), and electron flow specific to complex II (CIIP) (P < 0.05). Collectively, these findings supp

2 KB (354 words) - 21:47, 8 March 2020
Stepanova 2018 J Neurochem
...rol 3-phosphate. Our results underscore the critical importance of reverse electron transfer in the brain, where a significant amount of succinate can be accum ...ation, Antimycin A, Complex I, Ischemia/reperfusion, Mitochondria, Reverse electron transfer

3 KB (461 words) - 21:43, 13 April 2022
Groennebaek 2018 Front Physiol
...tochondrial protein synthesis and respiration increase with low-load blood flow restricted as well as high-load resistance training. Front Physiol 9:1796. ...ise with high loading may not constitute a viable approach. Low-load blood flow restricted resistance exercise (BFRRE) has emerged as a time-effective low-

4 KB (476 words) - 12:39, 8 August 2019
Petrick 2019 J Physiol
...Dennis KMJH, van Loon LJC, Burr JF, Goossens GH, Holloway GP (2019) Blood flow restricted resistance exercise and reductions in oxygen tension attenuate m ...submaximal (∼50-fold) mitochondrial ROS emission rates and the fraction of electron leak to ROS compared to room air (200 μm). Combined, these data demonstrat

3 KB (407 words) - 15:26, 15 October 2019
Plecita-Hlavata 2009 Int J Biochem Cell Biol
...ix-targeted ubiquinone MitoQ10 acts as anti-oxidant at retarded electron transport or proton pumping within Complex I. Int J Biochem Cell Biol 41:16 ...omplex I-derived superoxide generation is already elevated due to electron flow retardation. Moreover, unlike mitochondrial uncoupling, MitoQ10

3 KB (405 words) - 15:40, 13 November 2017
Schirris 2015 Cell Metab
...y inhibition in C2C12 myoblasts could be attenuated by convergent electron flow into CIII, restoring respiration up to 89% of control. In conclusion, CIII

2 KB (278 words) - 14:36, 27 March 2018
SUIT-018 AmR mt D040
...> production driven by the [[Reverse electron flow from CII to CI| reverse electron transfer]] (RET) in isolated mitochondria, tissue homogenate and permeabili

4 KB (625 words) - 12:09, 7 March 2024
Gnaiger 2011 Abstract-MonteVerita
...on. As a consequence, convergent electron flow from Complexes CI+II of the electron transfer-pathway ([[ET-pathway]]) to the [[Q-junction]] exerts an additive

3 KB (393 words) - 18:20, 10 January 2022
Morgan 2021 Resuscitation
...rrest underwent high-resolution respirometry to evaluate the mitochondrial electron transport system and immunohistochemical analyses to assess neuropathology. ...on pressure (25.0 ± 2.6 vs. 19.1 ± 1.8 mmHg; p = 0.02); and cerebral blood flow relative to baseline (rCBF: 243.2 ± 54.1 vs. 115.5 ± 37.2%; p =

3 KB (400 words) - 10:38, 22 July 2021
Bai 2016 PLOS ONE
...ntration in increased). These changes include altered directional electron flow, altered NADH/NAD+ redox cycling, metabolite exit, and OAA inhib

2 KB (299 words) - 16:52, 9 November 2017
Dent 2019 J Appl Physiol (1985)
...with muscle-specific knockout of STAT3 (mKO). First, we developed a novel flow cytometry-based approach to confirm that STAT3 is present in skeletal muscl

2 KB (319 words) - 11:27, 3 March 2020
Laner 2014 Abstract MiP2014
...ependent of the CHO substrate combination supporting CI&II-linked electron flow in the presence or absence of 0.2 mM octanoyl carnitine (FAO).

6 KB (853 words) - 18:30, 10 January 2022
The protonmotive force and respiratory control
::::* Flux and flow: clarification of normalization. ::::* '''[[Electron transfer pathway]]'''

12 KB (1,564 words) - 23:40, 25 January 2021
Timon-Gomez 2023 EUROMIT2023 Bologna
...m ischemia is defined as the time interval after the interruption of blood flow while the tissue remains at body temperature. The evaluation of mitochondri ...ude fatty acid oxidation F-, NADH N-, succinate S-, glycerol phosphate Gp- electron transfer (ET) pathways. Fluxes were normalized by tissue or protein mass, o

3 KB (478 words) - 13:44, 18 April 2023
Gnaiger 2018 MiPschool Tromso A1
...h Gnaiger.jpg|left|90px|Erich Gnaiger]] Mitochondrial states and rates: 1. Electron transfer pathways and respiratory control. 2. Coupling control. ...er-inhibitor titrations ([[SUIT]]) are applied to experimentally control [[electron transfer-pathway]]s in [[mitochondrial preparations]]. Complementary to [[p

10 KB (1,441 words) - 23:46, 25 January 2021
Simonin 2012 Biochem J
...d, in an FAD reduction assay, that SNAP blocked the intrinsic SDH electron flow in much the same way as thenoyltrifluoroacetone (TTFA), a noncompetitive SD

2 KB (337 words) - 10:17, 9 November 2016
Risiglione 2020 Int J Mol Sci
...vel, supported by increased LEAK respiration, and a drastic drop in oxygen flow devoted to ADP phosphorylation in respirometry measurements. Furthermore, p

3 KB (367 words) - 17:36, 5 October 2023
Rajendran 2019 EMBO Mol Med
...ons were essentially normalized by AOX, showing that the restored electron flow upstream of cIII was sufficient to prevent cardiac energetic crisis and det

2 KB (347 words) - 10:12, 8 June 2020
LEAK respiration
...flux]] in the LEAK state, ''J''O2''L'', or [[oxygen flow]], ''I''O2''L''). If these conditions are defined and ...ing. 2[H] indicates the reduced hydrogen equivalents of CHO substrates and electron transfer to oxygen. H+out are protons pumped out of t

12 KB (1,658 words) - 01:03, 31 December 2020
Chabi 2019 MiP2019
...M succinate (NS-OXPHOS capacity). 5U: uncoupler titrations to evaluate the electron transfer- (ET-) capacity (NS-ET capacity). 6Rot: inhibition of CI by roteno ...mitochondrial respiratory capacity by temperature in mouse heart: electron flow through the Q-junction in permeabilized fibers. Sci Rep 7:2840. [[SUIT-8_O2

7 KB (971 words) - 12:55, 21 February 2023
Chung 2018 J Exp Biol
...mitochondrial respiratory capacity by temperature in mouse heart: electron flow through the Q-junction in permeabilized fibers. Sci Rep 7:2840. [[Lemieux 2

3 KB (401 words) - 15:30, 5 January 2022
Chabi 2019 MitoFit Preprint Arch EA
...nate (NS-OXPHOS capacity). :'''5U:''' uncoupler titrations to evaluate the electron transfer- (ET-) capacity (NS-ET capacity). '''6Rot:''' inhibition of CI by ...mitochondrial respiratory capacity by temperature in mouse heart: electron flow through the Q-junction in permeabilized fibers. Sci Rep 7:2840, DOI:10.1038

8 KB (1,064 words) - 08:25, 8 January 2023
O2k-Publications: Topics
! MitoPedia: [[Electron-transfer-pathway state]]s | style="text-align:left"|Convergent CI- and CII-linked electron flow to the [[Q-junction]]

62 KB (7,038 words) - 14:31, 22 August 2023
SUIT-018
...> production driven by the [[Reverse electron flow from CII to CI| reverse electron transfer]] (RET) on isolated mitochondria, tissue homogenate and permeabili

5 KB (778 words) - 23:47, 12 April 2021
Havird 2019 Philos Trans R Soc Lond B Biol Sci
...mitochondrial respiratory capacity by temperature in mouse heart: electron flow through the Q-junction in permeabilized fibers. Sci Rep 7:2840. [[Lemieux 2

3 KB (422 words) - 15:30, 5 January 2022
Hand 2012 Abstract Bioblast
...ccinate) are added simultaneously, the increased electron flow through the Electron transfer-pathway ([[ET-capacity|''E'', non-coupled]]) allows the detection

5 KB (683 words) - 11:16, 8 June 2020
ET capacity
|description=[[File:E.jpg]] '''T capacity''' is the respiratory electron-transfer-pathway capacity ''E'' of mitochondria measured as oxygen consumpt ...arations supported by an ET-pathway competent state, exemplified as the NS-electron transfer pathway state (CI&II-linked substrate supply). Modi

11 KB (1,488 words) - 20:30, 19 March 2022
IOC recommended reading
...mitochondrial respiratory capacity by temperature in mouse heart: electron flow through the Q-junction in permeabilized fibers. Sci Rep 7:2840, DOI:10.1038 ::::» MitoPathways - the electron transfer-pathway

12 KB (1,521 words) - 14:23, 15 May 2023
Doerrier 2018 Methods Mol Biol
...le electron supply pathways converging at the Q-junction. ET-pathways with electron entry separately through NADH (pyruvate&malate or glutamate&malate) or succ

6 KB (850 words) - 12:27, 5 March 2024
Soltysinska 2014 PLoS One
...x-vivo model of ischemia/reperfusion (I/R) injury. Infarct areas, coronary flow and heart rates were not different between wild-type and BK-/- hearts upon

4 KB (507 words) - 13:45, 7 March 2020
Doerrier 2018 MiP2018c
...mitochondrial respiratory capacity by temperature in mouse heart: electron flow through the Q-junction in permeabilized fibers. Sci Rep 7:2840. - [[SUIT-00

7 KB (952 words) - 19:05, 10 January 2022
Hassan 2020 MitoFit Preprint Arch
...lymphoblastoid cell line and found that the oxidative phosphorylation and electron transfer of the NADH- and succinate-linked pathways, and cytochrome c oxida ...H., Alavi Shoushtari, A. & Villagonzalo, K. A. Targeting the mitochondrial electron transport chain in autism, a systematic review and synthesis of a novel the

13 KB (1,727 words) - 08:19, 8 January 2023
Oroboros Ecosystem Agenda 2024 Archive
...rs in bioenergetics''' will provide a fresh look at concepts in a state of flow rather than as fixed paradigms, which tend to be forgotten or distorted wit ...is simultaneous electron transfer from FAO into the Q-junction through the electron transferring flavoprotein dehydrogenase complex (CETFDH) and Complex I. <br

29 KB (4,269 words) - 09:03, 13 May 2024
Gnaiger 2019 MiP2019
...mitochondrial respiratory capacity by temperature in mouse heart: electron flow through the Q-junction in permeabilized fibers. Sci Rep 7:2840. - [[Lemieux

13 KB (1,952 words) - 19:12, 10 January 2022
Labieniec-Watala 2017 MiP2017
...lution respirometry; Oroboros Instruments, Innsbruck, Austria), as well as flow cytometry (BD FACS Canto II, BD Bioscience, San Jose, CA, USA) with the JC- ...itochondrial respirometry capacity by temperaturę in mouse heart: electron flow through the Q-junction in permeablized fibres. Sci Rep 7:2840, DOI:10.1038/

9 KB (1,293 words) - 04:19, 12 February 2020
Garcia-Roves 2019 MiPschool Coimbra
...mitochondrial respiratory capacity by temperature in mouse heart: electron flow through the Q-junction in permeabilized fibers. Sci Rep 7:2840, DOI:10.1038

7 KB (913 words) - 11:07, 3 July 2019
MitoFit Open Seminars
...es using two isolation methods: differential centrifugation and continuous-flow separation. - [[Garcia-Souza_LF#MitoEAGLE_Short-Term_Scientific_Mission|»A ...a 2018 J Cereb Blood Flow Metab|Stepanova ''et al.'' (2018), J Cereb Blood Flow Metab]]

33 KB (4,250 words) - 15:07, 2 February 2022
Gnaiger 2020 BEC MitoPathways
...idative phosphorylation (OXPHOS) determined in mitochondrial preparations, electron transfer (ET) capacity, LEAK respiration, and the distinction of uncoupled, ...0001.v1 Gnaiger et al 2000]). The effect of metabolic control variables on flow or flux can be expressed by normalization for rate in a ''reference state''

89 KB (12,074 words) - 17:54, 6 May 2024
Gnaiger 2014 MitoPathways
...962) Studies on the electron transfer-pathway. XLII. Reconstitution of the electron transfer-pathway. J Biol Chem 237:2661-9. - [[Hatefi 1962 J Biol Chem |»Bi :::# Mitchell P (1961) Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism. Nature 191:144-

51 KB (7,005 words) - 04:36, 19 July 2022
Template:O2k-PublicationAlert2022
|'''"Our results suggest increased proton and electron leak and a decreased ETS capacity in platelets in chronic smoke-exposed ani |'''"NS-linked OXPHOS and ET capacity [were] decreased after prolonged exposure to BAM15."

38 KB (5,234 words) - 13:18, 9 January 2023
Category:Ambiguity crisis - NAD and H+
...te of CI compared to succinate as substrate of CII. Their oxidation is a 2-electron reaction. == Supplement 2. Electron transfer from CI ⟶ CII ⟶ CIII ==

183 members (3 subcategories, 0 files) - 00:00, 28 November 2023
Oroboros Ecosystem Agenda 2021 Archive
|'''Coenzyme Q - a mobile redox compound in the electron transfer system ''' ...sues and cells. In humans, CoQ10 occurring in the mitochondrial electron transfer system transfers electrons from dehydrogenases and respiratory com

85 KB (11,819 words) - 14:18, 10 January 2022
Oroboros Ecosystem Agenda 2022 Archive
|'''"Our results suggest increased proton and electron leak and a decreased ETS capacity in platelets in chronic smoke-exposed ani |'''"NS-linked OXPHOS and ET capacity [were] decreased after prolonged exposure to BAM15."

87 KB (11,941 words) - 15:14, 16 November 2023
Gnaiger 2019 MitoFit Preprints
...esidual oxygen consumption, ROX, State 2, State 3, State 4, normalization, flow, flux, O2 ...bstrates (electron donors) and reduction of O2 catalysed by the electron transfer system, ETS: ('''mt''') mitochondrial catabolic respiration; ('''c

38 KB (5,252 words) - 08:27, 8 January 2023
Talk:MitoEAGLE Task Group States and rates
...respiratory states, to protonmotive force, to normalization of respiratory flow and flux; (''3'') the complex thermodynamic treatment in Section 3 of compa ...al determination of mitochondrial content via two-dimensional transmission electron microscopy can have limitations due to the dynamics of mitochondrial size (

192 KB (29,606 words) - 09:05, 18 March 2020
Gnaiger 2024 J Biol Chem
|title=Gnaiger E (2024) Complex II ambiguities ― FADH2 in the electron transfer system. J Biol Chem 300:105470. https://doi.org/10.1016/j.jbc.2023 ...ricarboxylic acid cycle. However, several graphical representations of the electron transfer system depict FADH2 in the mitochondrial matrix as a su

135 KB (18,142 words) - 13:29, 1 May 2024
BEC 2020.1 doi10.26124bec2020-0001.v1
...l count]] • [[Coupling-control ratio]] • [[Electron transfer pathway]] • [[Flow]] • [[Flux]] • [[Flux control ratio]] • [[IUPAC]] • [[LEAK respirat ...mitochondrial respiratory capacity by temperature in mouse heart: electron flow through the Q-junction in permeabilized fibers. Sci Rep 7:2840. - [[Lemieux

59 KB (8,156 words) - 13:41, 1 May 2024