Search results

...g applications. In contrast, the number of publications from North America has been relatively modest. Here, we review the field of nonequilibrium thermod

{{Abstract |abstract=Fatty acid oxidation in permeabilized muscle fibers has worked well for us in both human and rat studies. Typically we use Octanoyl

== Abstract == ...d for general, pre-clinical, and algal biotechnology applications. A focus has also been given to internal and external quality control measures.

...oan development, physiology, and disease pathogenesis. Remarkable progress has been made in delineating the molecular mechanisms whereby changes in cellul

...in regulating cellular function. The discovery of the mCa2+ uptake complex has shed new light on the role of mCa2+ dynamics in cytoskeletal remodeling, mi

{{Abstract ...ion dynamin related protein 1 (DRP1) has been recently challenged and Fis1 has been conversely implied in mitophagy, but the molecular mechanisms governin

|abstract=Skeletal muscle insulin resistance (IR) is inextricably likely has many mechanistic origins, but the primary

...has been expressed in Escherichia coli, and the recombinant human protein has the same kinetic properties as the corresponding protein purified from bovi

{{Abstract |abstract=[[Image:MITOEAGLE-logo.jpg|left|100px|link=http://www.mitoglobal.org/index.

{{Abstract ...mtDNA mutation for Lebers Hereditory Optic Neuropathy (LHON), this service has expanded to include a number of mtDNA mutations as well as some nuclear gen

...in circulation, and angiogenesis at sites of metastases. Low-dose aspirin has been demonstrated to block this procarcinogenic action of platelets. In thi

...differentiated generation stage once the appropriate developmental program has been engaged and also indicate that ORO is a key member of the developmenta

...nation and is completed in under 5 minutes, and mass spectroscopy analysis has shown enrichment of mitochondrial metabolites. Seahorse and Oroboros analys

...Our analysis proves, therefore, that the role of opportunism in evolution has converted a problem of several possible chemical solutions into a single-so

...tly the CoQ10H2/CoQ10 ratio changes considerably soon after a blood sample has been obtained. The time period since blood sampling and HPLC analysis, as w

|abstract=BACKGROUND: During the past 40 y, there has been a trend toward more eating away from home, increased food availability ...ur goal was to determine whether the body mass index (BMI)-height relation has changed over time.

...specified pure number of elementary entities. Hence the Avogadro constant has always been defined in terms of the unit of amount of substance, and not vi

|abstract= ASMRM 2020, Singapore, SG, 2021 '''This event has been postponed'''

...ascular events has been widely described. Thus, increased oxidative stress has been described in several atherosclerotic risk factors, such as hypertensio

|abstract=[[Komlodi 2022 Abstract Bioblast]]: The protonmotive force ''pmF'' establishes the link between ele ...al processes, such as production of reactive oxygen species, where the ΔpH has an important role.

...molecular machinery regulating mitochondrial Ca2+ accumulation and efflux has expanded the number of (patho)physiological conditions that rely on mitocho

...cal barriers. Mapping CoQ biosynthesis, metabolism, and transport pathways has great potential to enhance treatment of numerous human diseases.

...decline occurs as humans age. Increasing research on mitochondrial biology has elucidated the regulatory pathways involved in mitochondrial biogenesis, ma

|abstract=Chronic heart failure (CHF) is characterised by an inability of the heart t in nitric oxide (NO) bioavailability has been implicated as an initiator and/or contributor

...2+. Although ion-selective microelectrodes are widely used, this technique has certain assumptions, problems, and limitations that vary with the types of

|abstract=<big>'''Journal publication 2021-06-30 in [https://www.bioenergetics-commun |?Has title=Reference

...r investigators do not support a simple model in which climatic adaptation has been a major force during human mtDNA evolution.

...on. However, no protein candidate proposed as the actual pore-forming unit has passed rigorous gain- or loss-of-function genetic tests. Here we review evi

...ause of aging has been discussed over last decades. Accumulating evidences has indicated that genome instability including mitochondrial DNA in somatic ce

...l lines, including HeLA, HepG2, and skeletal muscle cells. As of yet, this has not been reproduced in neuronal cells. Using Neuro2a, a murine neuroblastom

...observations provide insights into eukaryotic NADP(+) biosynthesis, which has pivotal roles in cells and organelles.

...tained at -0.600 V vs Ag/AgCl. The magnitude of the oxidation peak current has been found to be related to the concentration of the coenzyme over the rang

...fully revealed. Owing to its safety and potential efficacy, H₂ has a promising potential for clinical use against many diseases. This review w

...bstrate for Complex II which accumulates during mitochondrial dysfunction, has been shown to have widespread effects as a signaling molecule. Here, we rev

{{Abstract ...mitochondria in a tissue. In patients with peripheral arterial disease it has been shown that the function and the amount of mitochondria depends on the

...erformed. Such as sample has to be stable for a certain amount of time and has to deliver the same results over and over ...nts have been done in certain intervals. The process of shipping the cells has also been mimicked by storing cells in a -20°C freezer for the period of o

...ondria and low oxidative capacity. The heat-producing brown adipose tissue has a high density of mitochondria and high oxidative capacity. Mitochondrial f

...nstruction of PI curves of unicellular organisms based on oxygen evolution has been difficult and time consuming due to the lack of sensitive instruments. :::: Supported by project [[NextGen-O2k]] which has received funding from the European Union’s Horizon 2020 research and inno

{{Abstract ...at an impaired mitochondrial function in one tissue (e.g. skeletal muscle) has strong metabolic consequences for the whole organism.

...and international trade, ''Where Corals Lie'' reveals how the threatening has become threatened; and of the danger this poses to humans. Exceptionally em

|abstract=.. From the start of my scientific career the galvanic cell, the first form ...appreciable elaboration since its acceptance, surely a clear sign that it has so far satisfied scientific needs. ..

...reviewed, a clear understanding of the regulation of cellular respiration has not yet been achieved. In particular, the role of tissue pO2 as a factor re cellular and intercellular messengers has evolved in the last few years and is

...t times of infection. Taking together, these results demonstrated that DHA has a potential anti-inflammatory and neuroprotective effect against ZIKV infec

{{Abstract ...lth consequences associated with excess weight, to the extent that obesity has recently been classified as a disease. Calorie restriction can induce weigh

...ax</sub>) with respect to ubiquinol-10 have been determined. The PL system has also been employed in dose-response assays with novel AOX inhibitors. Such

...tract=The interplay between platelets and tumors has long been studied. It has been widely accepted that platelets could promote tumor metastasis. However

...ts impair the specificities of cancer drugs. Blockade of kinase activities has been shown to converge on the energetic organelle, the mitochondria. In thi

...as important causes of disease. In addition, the study of these disorders has led to a greater understanding of the molecular mechanism of beta-oxidation

...e material into the body's own tissue. Unfortunately, however, this method has not yet arrived in practice. Therefore, we have made our own efforts to est

{{Abstract ...using reverse transcriptase polymerase chain reaction (RT-PCR) experiments has demonstrated that these genes are transcribed in many organisms [3]. Our fo

...nucleotide pool from tissue is dependent on the assay method. NADH ED-FRAP has been shown to be effective in measuring dehydrogenase activity in several e

...m of tissue cannot be obtained. Often, 0.5 grams must suffice. This method has been used successfully for the isolation of heart mitochondria from several

...electron transfer chain impairments, mitochondrial apoptosis and mitophagy has been outlined. Meanwhile, considerable efforts have been made towards under

{{Abstract ...efficiency through uncoupling. Mitochondrial heat generation in bumblebees has been largely discounted as they appear to lack uncoupling proteins, and if

...stress. This study aimed to demonstrate whether exercise before pregnancy has a protective effect on prenatal stress-induced impairment of memory, neurog

...ny such special properties. We review evidence here showing that trehalose has a remarkably high glass-transition temperature (Tg). It is not anomalous in

...t includes administering to the subject a pharmaceutical composition which has a therapeutically effective amount of an antimicrobial peptide containing a

...circulating to distant tissues. It is noteworthy that increasing evidence has demonstrated that mitokines are capable of reducing the metabolic-related H

|abstract=Worldwide, 1 in 3 women and 1 in 5 men over age 50 will experience fracture decline of bone with aging has been well studied, we were the first to find a

|abstract= TRACT General assembly meeting, Belfast, United Kingdom, 2018 This project has received funding from the European Union's Horizon 2020 research and innova

...ng, while itaconate (from another Krebs cycle intermediate, cis-aconitate) has an anti-inflammatory role.

...egulate autophagy and mitochondrial quality control. Conversely, autophagy has been shown to preserve NAD levels by modulating cellular stress. In this re

...ort chain into higher order assemblies, termed respiratory supercomplexes, has been established. Moreover, cardiolipin is involved in different stages of

...majority of the literature is not supporting this hypothesis. Recently it has been suggested that the production of reactive oxygen species play an essen

{{Abstract |abstract=[[Image:MITOEAGLE-logo.jpg|left|100px|link=http://www.mitoglobal.org/index.

|abstract= 32nd APS Annual Convention, Chicago, USA, 2020 :::: APS has regrettably determined it has no alternative but to cancel our in-person 32nd APS Annual Convention in Ch

...system in the cristae membrane under a mainly electrical p.m.f., Baum [6] has asked how the very small number of free protons in the inner aqueous phase

...ations in mitochondrial DNA on the rate of mitochondrial protein synthesis has revealed the existence of a 'translational threshold effect'. In this revie

|abstract=The subunit structure of oligomycin sensitive ATPase has been determined. In addition to the components of F1, and the so-called oli

...ace-water oxygenation. The discovery and cultivation of the Asgard archaea has reinforced metabolic evidence that eukaryogenesis was initially mediated by

{{Abstract ...ts impair the specificities of cancer drugs. Blockade of kinase activities has been shown to converge on the energetic organelle, the mitochondria. In thi

...tions have directed researchers towards utilising stem cells. Mitochondria has a major involvement in the pathophysiology of stroke and a number of other

...ure, the active site and quinone-binding site. Characterisation of the AOX has advanced considerably over recent years with information emerging about the

...cted debate. By contrast, recent application of molecular biological tools has brought major enlightenment at an exponential pace. Here we review some key

...lymphoid malignancies. An initial insufficient response to glucocorticoids has been shown to be an important prognostic marker for a bad outcome. Prior work has shown a downregulation of the mitochondrial glutamate/H+-symporter (SLC25A2

...rd party assessment and caution needed to prevent post-assessment pitfalls has been dealt with.

|title=Bhalla N (2016) Has the time come for preprints in biology? Mol Biol Cell 27:1185-7. |abstract=Preprints, non-peer-reviewed drafts of manuscripts available on the Interne

...nce in the study of cellular metabolism, particularly in the cancer field, has highlighted the fact that mitochondria are also critical biosynthetic and s

|abstract=[[Gnaiger 2022 Abstract Bioblast-PB]]: The bioenergetic crosstalk between mitochondria and chloropl |?Has title=Reference

...the tetrameric interfacial exo site resulted in dimeric mutants. ATP thus has dual functional roles in the mitochondrial malic enzyme.

...piratory defects and neuronal death has never been proven, this hypothesis has been supported by the detection of nonspecific mitochondrial DNA mutations

...igher risk. Although the prevalence of silent hypoxia in COVID-19 patients has been evident in several cases, the underlying pathomechanism behind this co

...stry, biology and nanoscience where counting measurements are common. This has caused debates about how the SI should address counting quantities and the

{{Abstract ...shown to localize in the brain. The unexpected presence of NOX in neurons has led to the idea that NOX-induced ROS are important in non-host defense cont

{{Abstract ...a role in the skeletal muscle wasting seen with DOX treatment. Recent work has shown that Metformin (MET) may protect against this oxidative environment b

...te and adenosine triphosphate have been determined as a function of pH. It has been found that the resonance absorption of the ''β''-P of adenosine triph

|abstract= 24th Kalorimetrietage, Braunschweig, Germany, 2021. ::::* Fromme Tobias: [[Fromme 2021 Abstract Kalorimetrietage |Application of different respirometric assay systems to c

{{Abstract |title=Lane N (2010) Mitochondria and the origin of complex life. Abstract MiP2010.

...een short- and long-term drug resistance mechanisms. Resultantly, FROST450 has the potential to be an important treatment option for cancer patients.

...0.55. It appears, therefore, that the isotope effect is more complex than has heretofore been assumed.

|abstract=SIGNIFICANCE: It is increasingly clear that proline metabolism plays an imp ...d redox cycling and maintenance of pyridine nucleotides. The reprogramming has been shown to shift in clonogenesis and/or metastasis.

...Gln-tRNAGln has to be formed by an indirect mechanism in the organelle. It has been demonstrated that human mitochondria contain a non-discriminating glut

== Abstract == ...ving mitochondrial function (Tab. 1). Mitochondrial respiratory competence has been reported in mononuclear human blood cells directly after storage at -8

...te its effects at a behavioral, morphological and biochemical levels. 3-NP has been used to reproduce the biochemical and pathophysiological characteristi

...t about ambiguity before Empson; as a result, the nature of his innovation has been poorly understood. ...other or both of two things has been meant, and the fact that a statement has several meanings.

...from abroad because the data are reported in unfamiliar terms. The system has broad immediate and future implications to American physicians.

...made to cover the varied aspects of anaerobic bacteria, and a bibliography has been included, which will allow individual topics to be pursued in greater ...n usefully with consequent increased growth, and the term ''anoxybiontic'' has been used to describe this situation.

...to proton translocation by an unknown mechanism. Dysfunction of complex I has been implicated in many human neurodegenerative diseases. We have determine

...the dissociation constant of the fluorescent indicator fura-2 for calcium has been determined in a physiologic buffer at 22 and 37 degrees C. For practic

|abstract= MitoGlobal This project has received funding from the European Union's Horizon 2020 research and innova

...medical scientists actually made a start earlier, reveals a researcher who has traced the "forgotten experiment" in which the National Institutes of Healt

{{Abstract ...ve phosphorylation in lymphocyte and subsequently improves immune function has not yet been established. This study elucidates how interval and continuous

|abstract=Proteomic analysis of early and late endosomes has been constrained by the limited purity of the endosomal fractions that can

...d we also consider other neurodegenerative diseases where oxidative stress has been implicated. Although much data remain to be collected, the broad spect

{{Abstract |abstract=The journal ''[[Bioenergetics Communications]]'' (BEC) was launched in the

|abstract=<big>'''Journal publication 2021-12-21 in [https://www.bioenergetics-commun ...e:Komlodi 2021 MitoFit AmR-O2 graphical abstract.png|right|300px|Graphical abstract]]The fluorometric Amplex UltraRed AmR assay is frequently used for quantita

...ic particles and no lipid phase transition at 14 degrees C in mitochondria has been reported.

|abstract=Dysfunctional bioenergetics has emerged as a key feature inmany This has led to the mitochondrial paradigm in which it has been

...steps of the citric acid cycle (Krebs cycle, tricarboxylic acid TCA cycle) has been characterized by the kinetic and regulatory properties of the enzymes |?Has title=Reference

|abstract=[[File:BEC.png|25px|link=https://www.bioenergetics-communications.org/index :::: Supported by project NextGen-O2k which has received funding from the European Union’s Horizon 2020 research and inno

...rgence and diversification, if any, has been intensely debated. Discussion has gravitated toward threshold levels of environmental free oxygen (O2) necess

...cientific invention. Reaven’s utterances proved pivotal, and nothing since has carried the gravitas of his proclamation. Aibo, on the other hand, will be ...inued dominance of our hunter–gatherer predecessors. But natural selection has turned on us. Life now favours inefficient phenotypes who fail to store ene

|abstract=mtFOIE GRAS Mid-term meeting, Pisa, Italy, 2018 This project has received funding from the European Union's Horizon 2020 research and innova

...onsidered as a body temperature of 36.4 to 37.8 °C. Normothermia, however, has a different definition in the context of [[ectotherms]]. ...itochondr Physiol Network MiP2013 | comparative mitochondrial physiology]] has become a hot topic where '''normothermia''' needs careful consideration.

..., Levitch, Dogonadze, and Jortner.5–11 For more than half of a century, ET has become an important ingredient in many modern research themes, which this s ...two-state and multi-state problems has been useful not only for ET, but it has also influenced the understanding of other processes, such as energy transf

...eration cell-permeable succinate prodrug to support mitochondrial function has positive overall effects in blunting the resultant bioenergy responses. Our

|abstract=Intracellular energy distribution has attracted much interest and has been proposed to occur in skeletal muscle via metabolite-facilitated diffus

|abstract=The mitochondrial respiratory chain has the crucial function of supplying the cell with energy in the form of ATP.

...demonstrate the control of mitochondrial mRNA synthesis by a protein that has an established role in regulating nuclear transcription and a link to mitoc

{{Abstract ...in sickness. Despite these negative effects, intermittent hypoxia exposure has been shown to be beneficial in some cases and the potential therapeutic ben

...e, Mendelian locus that was unlinked to the IMMEDIATE UPRIGHT locus, which has been shown to be necessary for full expression of the sporophyte developmen

...ross the membrane. It has a central role in cellular energy production and has been implicated in many human neurodegenerative diseases. The L-shaped enzy

...s normal kidney function. Improving mitochondrial homeostasis and function has the potential to restore renal function, and administering compounds that s

|abstract= Career Event of the FH Campus Wien, Virtual, 2021 ::::: 1st round: brief introduction of speakers, so that the audience has an idea of the background

...In this work we demonstrate, for the first time, that uncoupling protein 1 has the potential to regulate reactive oxygen species production in thymus mito

|abstract=Quantifying total cellular ATP production rate has become easier with recent technology and is essential to understanding ener

...volved have been only partially determined. Moreover, a synergistic effect has been found in several cancer types when it is administered in combination w

...are likely to play some role in reperfusion injury, priority and emphasis has been given to specific ROS sources that are enriched in certain tissues, su

|abstract= ..., such as the International Prototype of the Kilogram (IPK). The (general) abstract unit ‘kilogram’ had to be calibrated in balance against an (individual)

{{Abstract ...cise) is challenging and unfortunately the success rate is low. This topic has received major attention and yet the explanation behind the apparent inabil

...und after in vivo application of T(3). Our data thus demonstrate that T(3) has an important role in opening the mitochondrial membrane permeability pore a

...y provide a new effective molecular biomarker for the cancer detection. It has been suggested that establishing mtDNA defective pattern might be useful in

...catalyzing sulfide oxidation to thiosulfate in three consecutive reactions has been identified in rat liver as well as in the body-wall tissue of the lugw

...National Laboratory. This evolved into the “preprint” server arXiv, which has played a central role in information sharing in physics, mathematics, and r

...e defects could be major contributors to the neurodegenerative cascade, as has been reported in several neurodegenerative disorders. Drugs targeting the r

...ws that, although mitochondrial contribution to the pathogenesis of cancer has historically tended to be neglected, it is now evident that reprogrammed mi

|abstract=The [[International System of Units]], the SI, has been used around the world as the preferred system of units, the basic lang |?Has title=Reference

|abstract=The SciELO Program is setting in motion a basic plan for the development an ...and publication process of articles is a central issue that SciELO Brazil has been promoting by minimizing the time to indexing journals, the publication

...ylogeography of cattle genetic variants has been extensively described and has informed the history of domestication. However, there remains a dearth of d

{{Abstract |abstract=[[Image:MITOEAGLE-logo.jpg|left|100px|link=http://www.mitoglobal.org/index.

{{Abstract ...e homogenates (Thom), and permeabilized tissue fibres (Pfi), each of which has its pros and cons. Here, different mt preparations from two mammalian exper

...sion in proximity to certain mammalian cells when grown in culture. Oxygen has a low diffusion rate through cell culture media, thus, as a result of norma

...hnological development, especially electron microscopy and nanotechnology, has made it possible to obtain new scientific evidence that not only supports t

...the relationship between mitochondrial degradation and energetic activity has not yet been considered. Here, we report that the stimulation of mitochondr

...that such a shuttle operates similarly to the malate-aspartate shuttle; it has also been proposed that the two shuttles are necessarily interconnected in

...d, from both green and dark-grown plant materials. Only recently, however, has the method been applied to animal cells and tissues to supplant previous pr

{{Abstract ...tions, of which the very small cancer stem cell population is the one that has the growth and metastatic potential of the tumour. The other neoplastic cel

...on, from Tunisia, by performing complete mtDNA sequencing. This population has a mixed Eurasian/sub-Saharan mtDNA gene pool, which could potentially facil

...ses involved in production, distribution and removal. Substantial progress has been made exploring the formation and scavenging of H2O2, whereas little is

|abstract=19th Beijing Conference and Exhibition on Instrumental Analysis, Beijing, C :::: Oroboros participation was supported by the project NextGen-O2k which has received funding from the European Union’s Horizon 2020 research and inno

...ochrome c (Cyt c) release as a signal for programmed cell death. Complex I has been shown to generate reactive oxygen species (ROS), with key roles identi

{{Abstract |abstract=[[Image:MITOEAGLE-logo.jpg|left|100px|link=http://www.mitoglobal.org/index.

{{Abstract ...has been long utilised for the study of Ca²⁺ signaling [1]. It has been also engineered to induce its specific targeting to various cell regio

...uring the last 60-100 years the life style, at least in the Western world, has changed enormously. This became obvious with an increase in caloric intake,

...of the strongest aging theories proposed to date. The free radical theory has been expanded to the oxidative stress theory, in which mitochondria play a

...d death processes. Over the last decades, the 4,1-benzothiazepine CGP37157 has been the only available blocker of the mitochondrial sodium/calcium exchang

...ed as occurs in particular illnesses and injuries. Like a phoenix, lactate has risen to major importance in 21st century biology.

|abstract=Thomas Jefferson once observed, “I know of no safe depository of the ulti ...ughly 200 years since Jefferson made those pragmatic observations, science has provided incalculable knowledge and innovative tools that have improved peo

...in contradiction with empirical evidence, the diversity-stability paradox has survived the test of time for over 40+ years. In this paper we first show t

...lipotoxin accumulation in obesity. Experience from studies on xenobiotics has provided important insights into the regulation of hepatic mitochondria. In

|abstract=Purpose: Leber's hereditary optic neuropathy (LHON) is a genetic disease of ...r cell death. The conversion from the LHON carrier to the affected patient has been clinically characterized, but the pathophysiology is just beginning to

|abstract=Background ...yer in apoptosis and necrosis. Nitrite, a cellular nitric oxide reservoir, has a recognized role in cardiovascular protection, through still unclear mecha

...a. Cho-mediated elevation in mitochondrial PE is dependent on Vps39, which has been recently implicated in PE trafficking to the mitochondria. Accordingly

{{Abstract |abstract=Excess fructose consumption has been shown to mediate mitochondrial

{{Abstract ...cle, although recent reports have challenged this view. Previously our lab has demonstrated that directly targeting mitochondrial oxidative stress and ene

...ase in oxygen flux was observed following reoxygenation, a phenomenon that has been coined "oxidative burst". The amplitude of this "oxidative burst" was

|abstract=Brown adipose tissue (BAT) mitochondria are distinct from their counterpart ...for obesity and the metabolic abnormalities it incurs. Subsequently, there has been heightened interest in quantifying BAT function and more specifically,

...primary cells needed for bioenergetic analysis. This technical limitation has been overcome by combining the specificity of the magnetic bead isolation t

...ve stress has been implicated in pregnancy complications and previous work has shown that selenium can protect trophoblast mitochondria from oxidative str

...of the neurodegeneration observed in diabetic neuropathy. Our recent work has shown that mitochondrial dysfunction occurs in dorsal root ganglia (DRG) se

...been associated with numerous pathological conditions. In recent years it has become increasingly clear that oxidative and reductive modifications are co

{{Abstract ...mitochondrial evolution in a wide variety of species including humans and has the potential to provide a cohesive picture of the underlying mechanisms of

...ulture and strong opposition by some journal publishers [1]. The landscape has evolved rapidly in other fields in recent years, however, thanks to the lau

...nxiety and psychosis, while the inhibition of NOS and/or guanylate cyclase has been associated with an antidepressant response. This action of MB may cont

{{Abstract |abstract=Authors: [[Gama Perez Pau]]<br><br>

...thma. Montelukast, a robust antagonist of cysteinyl leukotriene receptors, has been widely applied for the therapies of bronchial asthma. However, the eff

...modality for various diseases involving mitochondrial dysfunction, but it has never been tested for sepsis.

{{Abstract ...and that the market demand for such solutions has reached a level where it has become viable for industry to invest in the development of commercial solut

...release from phosphocreatine hydrolysis in exercising CK-deficient muscle has been postulated to contribute to the lower fatigueability in skeletal muscl

|abstract= TRANSMIT Mid-Term Review Meeting, Bologna, Italy, 2018 This project has received funding from the European Union's Horizon 2020 research and innova

...ted in multiple cancers and, as with HSP90, evidence of addiction to TRAP1 has been observed. In this review, we summarize what is currently known about t

...rase and 2,4 dienoyl-CoA reductase). This review covers the knowledge that has been gained from these mouse models in terms of understanding both single-g

...e-site tyrosine (Tyr244) and that the neutral radical form of this residue has a more general role in the CcO mechanism than thought previously. This arti

...e in clinical trials. However, development of efficient personalized drugs has proved challenging and the combination with other strategies such as chemoc

{{Abstract ...a part in the skeletal muscle wasting seen with DOX treatment. Recent work has shown that exercise may help protect against this oxidative environment, th

...nnel blocker paxilline. In conclusion, these results suggest that luteolin has cardioprotective effects, at least in part, through the activation of the m

...mitochondrial deficiency with brain-specific manifestations. This proposal has been supported by recent mitochondrial DNA (mtDNA) analyses identifying bot

== Abstract == ...s (i) to compare the fitness and health status of a group of subjects that has been physically active for at least 6 years with an age and sex matched gro

|abstract= analytica China, Shanghai, China, 2024 :::: Since its debut in 2002, analytic China has become one of the biggest trade fairs in China. The exhibition portfolio fo

...-types, pulled away from the world of real things. The new SI (2019-05-20) has completed this total abstraction of units, from the previous necessity to n

...hain’ (ETC) is a misnomer. Understanding mitochondrial respiratory control has suffered greatly from this inappropriate terminology, although textbooks us

...hnology to replicate and maintain a physiological O2 environment in vitro, has hindered addressing this issue thus far. In this review, we aim to address

...gnosis, prognosis, and treatment. The study of mitochondrial bioenergetics has become critical in understanding the pathophysiology and treatment of compl

...es in metabolic rate or mitochondrial function. Malnutrition in early life has been linked to an increased likelihood to develop and an exacerbation of me

{{Abstract ...ricardium, most of which locates around the coronary artery. Recently, EAT has shown to be accumulated in coronary artery disease (CAD). However, the role

...ng time. Recently a new method based on mitochondria-targeted antioxidants has become the focus of interest. Here we review the current status of results

...ofiles. ''Juglans regia'', or common walnut, is a very resilient tree that has inhabited our planet for thousands of years. Many studies correlate walnut

...tween the tallest and shortest populations was 19-20 cm a century ago, and has remained the same for women and increased for men a century later despite s ...ribati where height has increased less than the worldwide median while BMI has increased a great deal.

{{Abstract ...except for the differences in their metabolism of citric acid. Recently it has been shown that alterations in metabolic activities of human prostate LNCaP

{{Abstract ...I will show that the topology of pores and protocells (and even the Earth) has been preserved in the structure of prokaryotic cells, where reversible flux

...roblem besetting people's daily life. Over the years, increasing attention has been paid to the study of anti-fatigue peptides. Several animal models have

...into three sub-classes, A, B and C, whose order of emergence in evolution has been controversial. Here we have analyzed recent structural and functional

{{Abstract ...from fatty acid oxidation and towards glucose uptake has been observed and has been proposed to represent an adaptive bioenergetic mechanism. We developed

...enhance sprint performance in humans. Although currently controversial, it has been reported that antioxidant ingestion during training may jeopardize som

{{Abstract ...ly also therapies receives a lot of attention in developed countries, this has not been the case in Africa. We have approached the identification and char

{{Abstract |abstract=[[File:Pesta_d.jpg‎|right|150px|Dominik Pesta]]

...iseases such as Parkinson’s disease (PD) and multiple sclerosis (MS). This has led to multiple attempts to use CoQ10 supplementation as a treatment or pre

{{Abstract |abstract=[[Image:MITOEAGLE-logo.jpg|left|100px|link=http://www.mitoglobal.org/index.

...mmed activities are now recognized as hallmarks of cancer, and recent work has uncovered remarkable flexibility in the specific pathways activated by tumo

|abstract=Gordon Research Seminar on Mitochondria & Chloroplasts, Ventura, West Dover :::: This conference has been withdrawn from the 2020 conference schedule

...these organelles important therapeutic targets. Mitochondrial dysfunction has been reported to occur in the setting of drug-induced toxicity in several t

...g selection in several species. Traditional testing of purifying selection has been based simply on ratios of nonsynonymous to synonymous mutations, witho

...great importance of cytoplasmic free Ca2+ in regulating cellular function has stimulated the development of several more-or-less calcium-selective sensor

...presents a major event that triggers a plethora of divergent responses and has therefore great potential to interfere with the experimental results and af

...dictable set of defects in all tissues. However, mitochondrial dysfunction has pleiotropic effects in multicellular organisms. Clearly, much about the bas

...e oxygen species (ROS) in the cellular response to cellular oxygen sensing has been controversial. Three papers in this issue of Cell Metabolism (Brunelle

...ed on the characteristics of the electromagnetic field. The new hypothesis has novel features which could be of biological interest.

...th hydrogenase in sequence and modular structure. The hydrogenase activity has been observed recently in complex I of higher plants. Based on these observ

...thors must disclose in their cover letter that a version of the manuscript has been deposited as a preprint and include any associated DOIs or accession n

...in, oxidative stress, or aberrant oncogene and tumor suppressor signaling, has been observed in a wide spectrum of human cancers. In this review, we summa

{{Abstract |abstract=Oral and oesophageal cancers are aggressive tumours associated with high mo

|abstract=The concept that cells die by a genetically regulated process has profound implications for human diseases in which too little or too much ce

...siological mechanisms of anoxia tolerance. However, relatively little work has been focused on what occurs beyond anoxia, and often the focus is a single

|abstract=Science is beautiful: it has truth, it has drama, it is full of wonder. The ''Mitchell's dream series'' is a vision of

...ing organ transplantation, whereas an RET-induced NAD+/NADH ratio decrease has been implicated in aging, age-related neurodegeneration, and cancer. In thi

...in part through its beneficial effects on mitochondrial function, and thus has been proposed as a possible anti-inflammatory therapy. We tested the hypoth

...for the generation of most of the cell's energy. Mitochondrial dysfunction has been implicated in cellular senescence in general and ovarian aging in part

{{Abstract |abstract=[[Image:MITOEAGLE-logo.jpg|left|100px|link=http://www.mitoglobal.org/index.

...of biological systems. While polyadenylation on mitochondrial transcripts has been suggested to be a two-step process required to complete translational

...l and the activity of other respiratory chain complexes. Hence, complex II has to be considered as an independent source of mitochondrial ROS in physiolog

...ific sub-mitochondrial localization or the dynamics of the interaction. It has been suggested that α-synuclein could only interact with ER-associated mit

...fect of reduced glomerular permeability for large molecules. Since hypoxia has been suggested as a common pathway to development of chronic kidney disease

...xidative phosphorylation. P53 originally identified as a tumor suppressor, has been demonstrated to be associated with energy metabolism. We proposed that

{{Abstract ...nce with mRNA transcription has a functional effect on translation. NDUFV2 has a pseudogene (NDUFV2P1), which is an attractive candidate for the regulatio

{{Abstract ...hown to be cardioprotective. Although the antioxidant effect of flavonoids has been long thought to be a crucial factor accounting for cellular cardioprot

{{Abstract |info=[http://ads-adea-2017.p.asnevents.com.au/days/2017-08-30/abstract/44893 Open Access]

...line in mammalian organisms. SIRT1, a NAD(+)-dependent deacetylase enzyme, has been suggested to mediate the adaptive responses to CR, leading to the spec

...to the high altitude regions, especially South America, Nepal, and India, has risen enormously in the past 10 years. Without special climbing ability the

...y. We thus report a novel function of BSF in flies and demonstrate that it has an important intra-mitochondrial role, which is essential for maintaining m

...obesity and diabetes. To date the measurement of bioenergetics parameters has required the use of cultured cells or extracted mitochondria with the corre

...future research suggestions for the prevention and treatment of DKD, which has important practical significance for the later treatment of patients with D

|abstract=[[File:BEC.png|25px|link=https://doi.org/10.26124/bec:2022-0019]] https://d ...nstruction of PI curves of unicellular organisms based on oxygen evolution has been difficult and time consuming due to the lack of sensitive instruments.

...uce ATP. We now show at the level of single oocytes, that supplied glucose has no effect on the redox potential of the oocyte. Pyruvate is a cytosolic oxi

{{Abstract |info=[https://academic.oup.com/jbcr/article-abstract/39/suppl_1/S176/4965623 Open Access]

|abstract=What brings the Earth to life, and our own lives to an end? For decades, biology has been dominated by information – the power of genes. Yet in terms of infor

...scribe the synthesis of new CGP37157 analogs, where the benzene-fused ring has been replaced by a pyridine. On top of a better water solubility and lower

...ant metabolic phenotype in cancer cells for a long time. More recently, it has been shown that mitochondria in most tumors are not defective in their abil

|abstract=Researchers posted more preprints to the [[bioRxiv]] server in 2018 alone t The analysis also shows that the number of downloads from the site has topped 1 million per month. BioRxiv, which allows researchers in the life s

...in plasma was believed to be similar to water. Here we reveal that plasma has an additional ascorbate-dependent oxygen-reduction activity. Plasma experim

{{Abstract |abstract=[[Image:MITOEAGLE-logo.jpg|left|100px|link=http://www.mitoglobal.org/index.