ETS capacity

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MitoPedia

ETS capacity

Description

E.jpg ETS capacity is the respiratory electron transfer system capacity, E, of mitochondria in the experimentally induced noncoupled state. Experimental determination of ETS capacity in mitochondrial preparations requires the measurement of oxygen consumption in the presence of defined substrates and of an established uncoupler at optimum concentration. This optimum concentration is determined by stepwise titration of the uncoupler up to the concentration inducing maximum flux as the determinant of ETS capacity. » MiPNet article

Abbreviation: E

Reference: Gnaiger 2014 MitoPathways, Gnaiger 2009 Int J Biochem Cell Biol


MitoPedia concepts: MiP concept, Respiratory state, Recommended 


MitoPedia methods: Respirometry 



MitoPedia topics: Uncoupler, EAGLE 

Noncoupled respiration with a shortcircuit of the proton cycle across the inner mt-membrane at optimum uncoupler (protonophore) concentration stimulating maximum oxygen flux. 2[H] indicates the reduced hydrogen equivalents of CHO substrates and electron transfer to oxygen. H+out are protons pumped out of the matrix phase. Proton leaks dissipate energy of translocated protons. ETS capacity is not limited by the capacity of the phosphorylation system (uncontrolled state). Measurement of ETS capacity is possible by uncoupler titrations in intact cells and in mt-preparations supported by an ETS-competent pathway control state, exemplifed as the NS-pathway control state (CI&II-linked substrate supply). Modified after Gnaiger 2014 MitoPathways).

Why ETS capacity, why not State 3u?

Publications in the MiPMap
Gnaiger E (2016) Why ETS capacity, why not State 3u? Mitochondr Physiol Network 2014-07-06, edited 2016-11-07, 2017-02-17.

»

OROBOROS (2016) MiPNet

Abstract: E.jpg Measurement of ETS capacity in the noncoupled state at optimum uncoupler concentration does not represent a general substitute for determination of OXPHOS capacity (compare State 3). If the ratio of OXPHOS/ETS capacity (P/E ratio) is less than one, noncoupled respiration overestimates the apparent reserve capacity for oxidative phosphorylation with respect to ROUTINE respiration of intact cells. The conditions for measurement and expression of respiration vary (oxygen flux in state E, JO2E or oxygen flow in state E, IO2E). If these conditions are defined and remain consistent within a given context, then the simple symbol E for respiratory state is used to substitute the more explicit expression for respiratory activity. In state E, the mt-membrane potential is almost fully collapsed and provides a reference state for flux control ratios.


O2k-Network Lab: AT Innsbruck Gnaiger E


Labels:




Coupling state: ETS 

HRR: Theory 



The important difference between states P and E

The abbreviation State 3u is used frequently in bioenergetics, to indicate the noncoupled state of maximum respiration, E,[1] without sufficient emphasis on the fundamental difference between state P (OXPHOS capacity; coupled, with an uncoupled component; State 3) and state E (ETS capacity, noncoupled) (Gnaiger 2009, 2014).
  • P=E: The specific case of equal OXPHOS and ETS capacity (P/E=1) yields the important information that the capacity of the phosphorylation system matches or is in potential excess of the ETS capacity, such that OXPHOS capacity is not limited by the phosphorylation system in the specific mitochondria. This varies with species and tissues, and changes as a result of pathologies due to defects in the phosphorylation system. An example for P/E=1 is mouse skeletal muscle mitochondria (Aragones et al 2008).
  • P<E: When OXPHOS is less than ETS capacity, the phosphorylation system limits OXPHOS capacity, and there is an apparent ETS excess capacity. For example, this is the case in healthy human skeletal muscle mitochondria (Pesta et al 2011).
  • P>E: If ETS is less than OXPHOS capacity in intact cells, or in mitochondrial preparations with defined substrate(s), then you have encountered an experimental artefact, and the apparent ETS capacity is too low. Artificially low ETS capacity may be obtained due to overtitration of uncoupler. Inhibitors of ATP synthase may suppress ETS capacity in intact cells, particularly in stressed cells.


Consequences for evaluation of coupling

In some textbooks on Bioenergetics, the RCR is defined as either the State 3/State 4 ratio or the State 3u/State 4 ratio. This reflects lack of conceptual distinction between State 3 (or P) and 3u (E), and clarification is best achieved by avoiding ambiguous terminology. RCR as defined originally is the 'acceptor control ratio' or 'adenylate control ratio' (see LEAK control ratio, L/E; biochemical coupling efficiency). ETS capacity but not OXPHOS capacity provides a valid reference for an index of uncoupling.


Related respiratory states

OXPHOS-coupled energy cycles. Source: The blue book
P.jpg OXPHOS, P
R.jpg ROUTINE, R
E.jpg ETS, E
L.jpg LEAK, L
ROX.jpg ROX, R

The ETS coupling state

ETS-related flux control factors

ETS-related flux control ratios


Related MitoPedia pages

  • Electron transfer system, ETS
» Electron transfer system
» Q-junction
  • Pathway control states
» Pathway control state
  • Coupling control state E
E.jpg ETS capacity
» Noncoupled respiration
» Is respiration uncoupled - noncoupled - dyscoupled?


References

  1. Gnaiger E. Electron transfer system versus electron transport chain. Mitochondr Physiol Network. »Electron transfer system«
  2. Gnaiger E. Is respiration uncoupled - noncoupled - dyscoupled? Mitochondr Physiol Network. »Uncoupler«
  3. Gnaiger E. Biochemical coupling efficiency: from 0 to <1. Mitochondr Physiol Network. »Biochemical coupling efficiency«
  1. Aragonés J, Schneider M, Van Geyte K, Fraisl P, Dresselaers T, Mazzone M, Dirkx R, Zacchigna S, Lemieux H, Jeoung NH, Lambrechts D, Bishop T, Lafuste P, Diez-Juan A, K Harten S, Van Noten P, De Bock K, Willam C, Tjwa M, Grosfeld A, Navet R, Moons L, Vandendriessche T, Deroose C, Wijeyekoon B, Nuyts J, Jordan B, Silasi-Mansat R, Lupu F, Dewerchin M, Pugh C, Salmon P, Mortelmans L, Gallez B, Gorus F, Buyse J, Sluse F, Harris RA, Gnaiger E, Hespel P, Van Hecke P, Schuit F, Van Veldhoven P, Ratcliffe P, Baes M, Maxwell P, Carmeliet P (2008) Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism. Nat Genet 40:170-80. »Bioblast link«
  2. Gnaiger E. Biochemical coupling efficiency: from 0 to <1. Mitochondr Physiol Network. - »Biochemical coupling efficiency«
  3. Gnaiger E (2009) Capacity of oxidative phosphorylation in human skeletal muscle. New perspectives of mitochondrial physiology. Int J Biochem Cell Biol 41:1837-45. - »Bioblast link«
  4. Gnaiger E (2014) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 4th ed. Mitochondr Physiol Network 19.12. OROBOROS MiPNet Publications, Innsbruck:80 pp. »Bioblast link«
  5. Hatefi Y, Haavik AG, Fowler LR, Griffiths DE (1962) Studies on the electron transfer system XLII. Reconstitution of the electron transfer system. J Biol Chem 237:2661-9. - »Bioblast link«
  6. International Union of Biochemistry (1991) Nomenclature of electron-transfer proteins. Biochim Biophys Acta 1060. »Open Access«
  7. International Union of Biochemistry and Molecular Biology. Recommendations for terminology and databases for biochemical thermodynamics - The IUPAC Green Book. »Open Access«
  8. Pesta D, Hoppel F, Macek C, Messner H, Faulhaber M, Kobel C, Parson W, Burtscher M, Schocke M, Gnaiger E (2011) Similar qualitative and quantitative changes of mitochondrial respiration following strength and endurance training in normoxia and hypoxia in sedentary humans. Am J Physiol Regul Integr Comp Physiol 301:R1078–87. »Bioblast link«


Publications in the MiPMap

List of publications: ETS

Sort in ascending/descending order by a click on one of the small symbols in squares below.
Default sorting: chronological. Empty fields appear first in ascending order. 
 YearReferenceCouplingPathwayPreparationOrganismTissue;cell
MiPNet15.09. Yeast: HRR Reference Assay2017-02-05
O2k-Protocols
A mitochondrial reference assay for high-resolution respirometry using freeze-dried Baker’s yeast.
ROUTINE
ETS
ROXSaccharomyces cerevisiae
Fungi
Uppala 2017 Biochem Biophys Res Commun2017Uppala R, Dudiak B, Beck ME, Bharathi SS, Zhang Y, Stolz DB, Goetzman ES (2017) Aspirin increases mitochondrial fatty acid oxidation. Biochem Biophys Res Commun 482:346-51.OXPHOS
ETS
F
N
NS
Permeabilized cellsHuman
Mouse
HEK
Fibroblast
Harisseh 2017 Basic Res Cardiol2017Harisseh R, Pillot B, Gharib A, Augeul L, Gallo-Bona N, Ferrera R, Loufouat J, Delale T, Allas S, Abribat T, Crola Da Silva C, Ovize M (2017) Unacylated ghrelin analog prevents myocardial reperfusion injury independently of permeability transition pore. Basic Res Cardiol 112:4.OXPHOS
ETS
N
S
CIV
ROX
Permeabilized tissueMouseHeart
Lemieux 2017 bioRxiv2017Lemieux H, Blier PU, Gnaiger E (2017) Remodeling pathway control of oxidative phosphorylation by temperature in the heart. bioRxiv doi: https://doi.org/10.1101/103457.LEAK
OXPHOS
ETS
N
S
NS
Permeabilized tissueMouseHeart
Schatton 2017 J Cell Biol2017Schatton D, Pla-Martin D, Marx MC, Hansen H, Mourier A, Nemazanyy I, Pessia A, Zentis P, Corona T, Kondylis V, Barth E, Schauss AC, Velagapudi V, Rugarli EI (2017) CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs. J Cell Biol [Epub ahead of print].LEAK
OXPHOS
ETS
N
NS
Intact cells
Isolated mitochondria
MouseLiver
Garcia-Neto 2017 PLOS ONE2017Garcia-Neto W, Cabrera-Orefice A, Uribe-Carvajal S, Kowaltowski AJ, Alberto Luévano-Martínez L (2017) High osmolarity environments activate the mitochondrial alternative oxidase in Debaryomyces Hansenii. PLOS ONE 12:e0169621.ETSN
S
CIV
ROX
Isolated mitochondriaFungi
MiPNet21.17 BloodCellsIsolation2016-11-14
O2k-Protocols
O2k-Protocols: Isolation of blood cells for HRR.
LEAK
ROUTINE
OXPHOS
ETS
F
N
S
Gp
CIV
NS
ROX
Intact cells
Permeabilized cells
MouseBlood cells
Lymphocyte
Platelet
MiPNet21.06 SUIT RP2016-08-17
O2k-Protocols
SUIT reference protocol for OXPHOS analysis by high-resolution respirometry.
LEAK
OXPHOS
ETS
F
N
S
Gp
CIV
NS
Other combinations
Permeabilized cells
Permeabilized tissue
Homogenate
Isolated mitochondria
MiPNet08.09 CellRespiration2016-08-11
O2k-Protocols contents
High-resolution respirometry and coupling control protocol with intact cells: ROUTINE, LEAK, ETS, ROX.
LEAK
ROUTINE
ETS
Intact cellsHumanBlood cells
Lymphocyte
MiPNet10.04 CellRespiration2016-08-08
O2k-Protocols
An experiment with high-resolution respirometry: coupling control in cell respiration.
LEAK
ROUTINE
ETS
ROXIntact cellsMouseBlood cells
MiPNet21.07 MitoFit DatLab PT2016-07-20
O2k-Protocols
MitoFit DatLab proficiency test.
LEAK
OXPHOS
ETS
F
N
S
Gp
CIV
Other combinations
ROX
Permeabilized cellsHuman
MiPNet12.23 FibreRespiration2016-07-19
O2k-Protocols contents
Mitochondrial respiration in permeabilized fibres: Needle biopsies from horse skeletal muscle.
LEAK
OXPHOS
ETS
N
S
NS
Permeabilized tissueHorseSkeletal muscle
Kontro 2016 Thesis2016Kontro H (2016) Mitochondrial function and sirtuin expression in hippocampus of young and old high and low-capacity runner rats. Master's Thesis p35.ETS
LEAK
OXPHOS
N
NS
ROX
S
HomogenateRatNervous system
Van Hoose 2016 J Nutr Biochem2016Van Hoose PM, Kelm NQ, Piell KM, Cole MP (2016) Conjugated linoleic acid and nitrite attenuate mitochondrial dysfunction during myocardial ischemia. J Nutr Biochem 34:8-16.LEAK
OXPHOS
ETS
N
ROX
Isolated mitochondriaMouseHeart
Boutant 2016 Cell Rep2016Boutant M, Kulkarni SS, Joffraud M, Raymond F, Métairon S, Descombes P, Cantó C (2016) SIRT1 gain of function does not mimic or enhance the adaptations to intermittent fasting. Cell Rep 14:2068-75.OXPHOS
ETS
N
NS
Permeabilized tissue
Homogenate
MouseSkeletal muscle
Liver
Fat
Most 2016 Am J Clin Nutr2016Most J, Timmers S, Warnke I, Jocken JW, van Boekschoten M, de Groot P, Bendik I, Schrauwen P, Goossens GH, Blaak EE (2016) Combined epigallocatechin-3-gallate and resveratrol supplementation for 12 wk increases mitochondrial capacity and fat oxidation, but not insulin sensitivity, in obese humans: a randomized controlled trial. Am J Clin Nutr 104:215-27.LEAK
OXPHOS
ETS
F
N
NS
Permeabilized tissueHumanSkeletal muscle
Chang 2016 Transl Res2016Chang JC, Wu SL, Liu KH, Chen YH, Chuang CS, Cheng FC, Su HL, Wei YH, Kuo SJ, Liu CS (2016) Allogeneic/xenogeneic transplantation of peptide-labeled mitochondria in Parkinson's disease: restoration of mitochondria functions and attenuation of 6-hydroxydopamine-induced neurotoxicity. Transl Res 170:40-56.LEAK
OXPHOS
ETS
NIsolated mitochondriaRatNervous system
Other cell lines
Vevera 2016 Physiol Res2016Vevera J, Fišar Z, Nekovářová T, Vrablík M, Zlatohlávek L, Hroudová J, Singh N, Raboch J, Valeš K (2016) Statin-induced changes in mitochondrial respiration in blood platelets in rats and human with dyslipidemia. Physiol Res 65:777-88.LEAK
ROUTINE
OXPHOS
ETS
N
S
NS
Other combinations
ROX
Intact cells
Permeabilized cells
Human
Rat
Blood cells
Platelet
Asseburg 2016 Neuromolecular Med2016Asseburg H, Schäfer C, Müller M, Hagl S, Pohland M, Berressem D, Borchiellini M, Plank C, Eckert GP (2016) Effects of grape skin extract on age-related mitochondrial dysfunction, memory and life span in C57BL/6J mice. Neuromolecular Med 18:378-95.LEAK
OXPHOS
ETS
N
S
CIV
NS
ROX
Isolated mitochondriaMouseNervous system
Pamenter 2016 Biol Lett2016Pamenter ME, Gomez CR, Richards JG, Milsom WK (2016) Mitochondrial responses to prolonged anoxia in brain of red-eared slider turtles. Biol Lett 12. pii: 20150797.LEAK
OXPHOS
ETS
N
S
CIV
ROX
Permeabilized tissueReptilesNervous system
Reynolds 2016 Am J Physiol Endocrinol Metab2016Reynolds MS, Hancock CR, Ray JD, Kener KB, Draney C, Garland K, Hardman J, Bikman BT, Tessem JS (2016) β-cell deletion of Nr4a1 and Nr4a3 nuclear receptors impedes mitochondrial respiration and insulin secretion. Am J Physiol Endocrinol Metab 311:E186-201.LEAK
ROUTINE
OXPHOS
ETS
N
S
ROX
Intact cells
Permeabilized cells
RatIslet cell;pancreas;thymus
Porter 2016 Cell Metab2016Porter C, Herndon DN, Chondronikola M, Chao T, Annamalai P, Bhattarai N, Saraf MK, Capek KD, Reidy PT, Daquinag AC, Kolonin MG, Rasmussen BB, Borsheim E, Toliver-Kinsky T, Sidossis LS (2016) Human and mouse brown adipose tissue mitochondria have comparable UCP1 function. Cell Metab 24:246-55.LEAK
OXPHOS
ETS
F
N
NS
Other combinations
Permeabilized tissueHuman
Mouse
Skeletal muscle
Fat
Moll 2016 bioRxiv2016Moll CWI, Lindtner RA, Vogel GF, Brunner M, Gutleben K, Blauth M, Krumschnabel G, Ebner HL (2016) Bone marrow mesenchymal stem cells from osteoporotic patients do not show altered mitochondrial energetics or ultrastructure. bioRxiv doi.org/10.1101/046300.LEAK
ROUTINE
OXPHOS
ETS
N
S
ROX
Intact cells
Permeabilized cells
HumanStem cells
Du 2016 J Exp Biol2016Du SN, Mahalingam S, Borowiec BG, Scott GR (2016) Mitochondrial physiology and reactive oxygen species production are altered by hypoxia acclimation in killifish (Fundulus heteroclitus). J Exp Biol 219:1130-8.LEAK
OXPHOS
ETS
N
S
CIV
NS
Isolated mitochondriaFishesLiver
Jang 2016 J Intensive Care Med2016Jang DH, Greenwood JC, Spyres MB, Eckmann D (2016) Measurement of mitochondrial respiration and motility in acute care: sepsis, trauma, and poisoning. J Intensive Care Med 32:86-94.LEAK
ROUTINE
ETS
ROXIntact cellsBlood cells
Lymphocyte
Sanchez-Calvo 2016 PLOS ONE2016Sánchez-Calvo B, Cassina A, Rios N, Peluffo G, Boggia J, Radi R, Rubbo H, Trostchansky A (2016) Nitro-arachidonic acid prevents Angiotensin II-induced mitochondrial dysfunction in a cell line of kidney proximal tubular cells. PLOS ONE 11:e0150459.LEAK
ROUTINE
ETS
ROXIntact cellsHumanKidney
Other cell lines
Schoenenberger 2016 Cancer Res2016Schönenberger D, Harlander S, Rajski M, Jacobs RA, Lundby AK, Adlesic M, Hejhal T, Wild PJ, Lundby C, Frew IJ (2016) Formation of renal cysts and tumors in Vhl/Trp53-deficient mice requires HIF1α and HIF2α. Cancer Res 76:2025-36.OXPHOS
ETS
F
N
S
CIV
NS
ROX
Permeabilized tissueMouseNervous system
Tyrrell 2016 Redox Biol2016Tyrrell DJ, Bharadwaj MS, Jorgensen MJ, Register TC, Molina AJ (2016) Blood cell respirometry is associated with skeletal and cardiac muscle bioenergetics: Implications for a minimally invasive biomarker of mitochondrial health. Redox Biol 10:65-77.OXPHOS
ETS
N
NS
ROX
Permeabilized tissueOther mammalsSkeletal muscle
Puskarich 2016 J Crit Care2016Puskarich MA, Kline JA, Watts JA, Shirey K, Hosler J, Jones AE (2016) Early alterations in platelet mitochondrial function are associated with survival and organ failure in patients with septic shock. J Crit Care 31:63-7.LEAK
ROUTINE
ETS
ROXIntact cellsHumanBlood cells
Platelet
Kimball 2016 Thesis2016Kimball RL (2016) The role of hypoxia on pyruvate kinase M2, mammalian target of rapamycin, mitochondrial function, and cell invasion in the trophoblast. Master Thesis p55.LEAK
OXPHOS
ETS
N
S
NS
ROX
Permeabilized cellsHumanGenital
Other cell lines
McCourt 2016 PLOS ONE2016McCourt AC, Jakobsson L, Larsson S, Holm C, Piel S, Elmér E, Björkqvist M (2016) White adipose tissue browning in the R6/2 mouse model of Huntington's disease. PLOS ONE 11:e0159870.ETS
LEAK
OXPHOS
NS
ROX
Permeabilized cellsMouseFat
Brecht 2016 Toxicol In Vitro2016Brecht K, Riebel V, Couttet P, Paech F, Wolf A, Chibout SD, Pognan F, Krähenbühl S, Uteng M (2016) Mechanistic insights into selective killing of OXPHOS-dependent cancer cells by arctigenin. Toxicol In Vitro 40:55-65.LEAK
OXPHOS
ETS
N
S
CIV
Other combinations
ROX
Permeabilized cellsHumanIslet cell;pancreas;thymus
Du 2016 Aquat Toxicol2016Du X, Crawford DL, Nacci DE, Oleksiak MF (2016) Heritable oxidative phosphorylation differences in a pollutant resistant Fundulus heteroclitus population. Aquat Toxicol 177:44-50.LEAK
OXPHOS
ETS
N
S
CIV
Other combinations
ROX
Permeabilized cellsFishesLiver
Van Eunen 2016 BMC Biol2016van Eunen K, Volker-Touw CM, Gerding A, Bleeker A, Wolters JC, van Rijt WJ, Martines AM, Niezen-Koning KE, Heiner RM, Permentier H, Groen AK, Reijngoud DJ, Derks TG, Bakker BM (2016) Living on the edge: substrate competition explains loss of robustness in mitochondrial fatty-acid oxidation disorders. BMC Biol 14:107.OXPHOS
ETS
F
N
Isolated mitochondriaMouseLiver
Barison 2016 J Bioenerg Biomembr2016Barisón MJ, Damasceno FS, Mantilla BS, Silber AM (2016) The active transport of histidine and its role in ATP production in Trypanosoma cruzi. J Bioenerg Biomembr 48:437-49.LEAK
ROUTINE
ETS
Intact cellsProtists
Schmidt 2016 J Vasc Surg2016Schmidt CA, Ryan TE, Lin CT, Inigo MM, Green TD, Brault JJ, Spangenburg EE, McClung JM (2016) Diminished force production and mitochondrial respiratory deficits are strain-dependent myopathies of subacute limb ischemia. J Vasc Surg [Epub ahead of print].OXPHOS
ETS
N
S
CIV
NS
Permeabilized tissue
Isolated mitochondria
MouseSkeletal muscle
Chu 2016 World J Gastroenterol2016Chu MJ, Premkumar R, Hickey AJ, Jiang Y, Delahunt B, Phillips AR, Bartlett A (2016) Steatotic livers are susceptible to normothermic ischemia-reperfusion injury from mitochondrial Complex-I dysfunction. World J Gastroenterol 22:4673-84.LEAK
OXPHOS
ETS
N
S
NS
ROX
HomogenateRatLiver
Kawalec 2016 Praca doktorska2016Kawalec MM (2016) Badanie komórkowych skutków mutacji w genie mitofuzyny 2. Próba zaproponowania testu patogenności mutacji. Praca doktorska p86.LEAK
ROUTINE
ETS
Intact cellsMouseFibroblast
Smith 2016 Diabetes2016Smith BK, Ford RJ, Desjardins EM, Green AE, Hughes MC, Houde VP, Day EA, Marcinko K, Crane JD, Mottillo EP, Perry CG, Kemp BE, Tarnopolsky MA, Steinberg GR (2016) Salsalate (Salicylate) uncouples mitochondria, improves glucose homeostasis, and reduces liver lipids independent of AMPK β1. Diabetes 65:3352-61.ETS
LEAK
OXPHOS
F
N
NS
Other combinations
ROX
Isolated mitochondria
Permeabilized cells
MouseFat
Liver
Skeletal muscle
Volt 2016 J Pineal Res2016Volt H, García JA, Doerrier C, Díaz-Casado ME, Guerra-Librero A, López LC, Escames G, Tresguerres JA, Acuña-Castroviejo D (2016) Same molecule but different expression: aging and sepsis trigger NLRP3 inflammasome activation, a target of melatonin. J Pineal Res 60:193-205.OXPHOS
ETS
N
NS
Permeabilized tissueMouseHeart
Cagnone 2016 Sci Rep2016Cagnone GL, Tsai TS, Makanji Y, Matthews P, Gould J, Bonkowski MS, Elgass KD, Wong AS, Wu LE, McKenzie M, Sinclair DA, John JC (2016) Restoration of normal embryogenesis by mitochondrial supplementation in pig oocytes exhibiting mitochondrial DNA deficiency. Sci Rep 6:23229.ETS
LEAK
OXPHOS
ROX
S
Isolated mitochondriaPigGenital
Sengupta 2016 Free Radic Biol Med2016Sengupta S, Yang G, O'Donnell JC, Hinson MD, McCormack SE, Falk MJ, La P, Robinson MB, Williams ML, Yohannes MT, Polyak E, Nakamaru-Ogiso E, Dennery PA (2016) The circadian gene Rev-erbα improves cellular bioenergetics and provides preconditioning for protection against oxidative stress. Free Radic Biol Med 93:177-89.LEAK
ROUTINE
ETS
ROXIntact cellsMouseLung;gill
Fibroblast
McCurdy 2016 JCI Insight2016McCurdy CE, Schenk S, Hetrick B, Houck J, Drew BG, Kaye S, Lashbrook M, Bergman BC, Takahashi DL, Dean TA, Nemkov T, Gertsman I, Hansen KC, Philp A, Hevener AL, Chicco AJ, Aagaard KM, Grove KL, Friedman JE (2016) Maternal obesity reduces oxidative capacity in fetal skeletal muscle of Japanese macaques. JCI Insight 1:e86612.LEAK
OXPHOS
ETS
F
N
S
NS
Permeabilized tissueOther mammalsSkeletal muscle
Seiferling 2016 EMBO Rep2016Seiferling D, Szczepanowska K, Becker C, Senft K, Hermans S, Maiti P, König T, Kukat A, Trifunovic A (2016) Loss of CLPP alleviates mitochondrial cardiomyopathy without affecting the mammalian UPRmt. EMBO Rep 17:953-64.LEAK
OXPHOS
ETS
N
NS
Isolated mitochondriaMouseHeart
Pathway control state2016Gnaiger E (2017) Pathway control states. Mitochondr Physiol Network 2016-08-12, edited 2016-11-08, 2017-02-17.LEAK
OXPHOS
ETS
F
N
S
Gp
CIV
NS
Other combinations
Permeabilized cells
Permeabilized tissue
Homogenate
Isolated mitochondria
SMP
Iglesias-Gonzalez 2016 Mol Neurobiol2016Iglesias-González J, Sánchez-Iglesias S, Beiras-Iglesias A, Méndez-Álvarez E, Soto-Otero R (2016) Effects of aluminium on rat brain mitochondria bioenergetics: an in vitro and in vivo study. Mol Neurobiol 54:563-70.LEAK
OXPHOS
ETS
N
S
NS
Isolated mitochondriaRatNervous system
Gregg 2016 Diabetes2016Gregg T, Poudel C, Schmidt BA, Dhillon RS, Sdao SM, Truchan NA, Baar EL, Fernandez LA, Denu JM, Eliceiri KW, Rogers JD, Kimple ME, Lamming DW, Merrins MJ (2016) Pancreatic β cells from mice offset age-associated mitochondrial deficiency with reduced KATP channel activity. Diabetes 65:2700-10.LEAK
OXPHOS
ETS
N
S
NS
ROX
Permeabilized tissueHuman
Mouse
Islet cell;pancreas;thymus
Other cell lines
Jang 2016 Clin Toxicol (Phila)2016Jang DH, Shofer FS, Weiss SL, Becker LB (2016) Impairment of mitochondrial respiration following ex vivo cyanide exposure in peripheral blood mononuclear cells. Clin Toxicol (Phila) 54:303-7.LEAK
ROUTINE
ETS
ROXIntact cellsHumanBlood cells
Lymphocyte
Boeck 2016 Mitochondrion2016Boeck C, Koenig AM, Schury K, Geiger ML, Karabatsiakis A, Wilker S, Waller C, Gündel H, Fegert JM, Calzia E, Kolassa IT (2016) Inflammation in adult women with a history of child maltreatment: The involvement of mitochondrial alterations and oxidative stress. Mitochondrion 30:197-207.LEAK
ROUTINE
ETS
ROXIntact cellsHumanBlood cells
Lymphocyte
Pohland 2016 Neurochem Res2016Pohland M, Hagl S, Pellowska M, Wurglics M, Schubert-Zsilavecz M, Eckert GP (2016) MH84: a novel γ-secretase modulator/PPARγ agonist-improves mitochondrial dysfunction in a cellular model of Alzheimer's disease. Neurochem Res 41:231-42.LEAK
OXPHOS
ETS
N
S
CIV
NS
ROX
Permeabilized cellsHumanKidney
HEK
Distefano 2016 J Gerontol A Biol Sci Med Sci2016Distefano G, Standley RA, Dubé JJ, Carnero EA, Ritov VB, Stefanovic-Racic M, Toledo FG, Piva SR, Goodpaster BH, Coen PM (2016) Chronological age does not influence ex-vivo mitochondrial respiration and quality control in skeletal muscle. J Gerontol A Biol Sci Med Sci [Epub ahead of print].LEAK
OXPHOS
ETS
N
S
NS
Permeabilized tissueHumanSkeletal muscle
Watala 2016 Int J Pharm2016Watala C, Karolczak K, Kassassir H, Siewiera K, Maczynska K, Pieniazek A, Labieniec-Watala M (2016) How do the full-generation poly(amido)amine (PAMAM) dendrimers activate blood platelets? Platelet membrane zeta potential and other membrane-associated phenomena. Int J Pharm 500:379-89.LEAK
ROUTINE
ETS
ROXIntact cellsHumanBlood cells
Platelet
Torres 2016 Redox Biol2016Torres S, Matías N, Baulies A, Nuñez S, Alarcon-Vila C, Martinez L, Nuño N, Fernandez A, Caballeria J, Levade T, Gonzalez-Franquesa A, Garcia-Rovés P, Balboa E, Zanlungo S, Fabrías G, Casas J, Enrich C, Garcia-Ruiz C, Fernández-Checa JC (2016) Mitochondrial GSH replenishment as a potential therapeutic approach for Niemann Pick type C disease. Redox Biol 11:60-72.LEAK
ROUTINE
OXPHOS
ETS
N
S
ROX
HomogenateHuman
Mouse
Nervous system
Liver
Endothelial;epithelial;mesothelial cell
Fibroblast
Amaral 2016 J Neurochem2016Amaral AU, Cecatto C, Castilho RF, Wajner M (2016) 2-methylcitric acid impairs glutamate metabolism and induces permeability transition in brain mitochondria. J Neurochem 137:62-75.LEAK
OXPHOS
ETS
N
S
NS
Isolated mitochondriaRatNervous system
Ryan 2016 Diabetes2016Ryan TE, Schmidt CA, Green TD, Spangenburg EE, Neufer PD, McClung JM (2016) Targeted expression of catalase to mitochondria protects against ischemic myopathy in high fat fed mice. Diabetes 65:2553-68.LEAK
OXPHOS
ETS
N
S
CIV
Other combinations
ROX
Isolated mitochondriaMouseSkeletal muscle
Schinagl 2016 PLoS One2016Schinagl CW, Vrabl P, Burgstaller W (2016) Adapting high-resolution respirometry to glucose-limited steady state mycelium of the filamentous fungus Penicillium ochrochloron: method development and standardisation. PLoS One 11:e0146878.ROUTINE
ETS
Intact cellsFungi
Ruas 2016 PLOS ONE2016Ruas JS, Siqueira-Santos ES, Amigo I, Rodrigues-Silva E, Kowaltowski AJ, Castilho RF (2016) Underestimation of the maximal capacity of the mitochondrial electron transport system in oligomycin-treated cells. PLOS ONE 11:e0150967.LEAK
OXPHOS
ETS
NIntact cells
Permeabilized cells
Isolated mitochondria
Human
Rat
Nervous system
Genital
Other cell lines
Moore 2016 Cryobiology2016Moore DS, Hand SC (2016) Cryopreservation of lipid bilayers by LEA proteins from Artemia franciscana and trehalose. Cryobiology 73:240-7.LEAK
OXPHOS
ETS
SIsolated mitochondriaRatLiver
Nissinen 2016 Sci Rep2016Nissinen TA, Degerman J, Räsänen M, Poikonen AR, Koskinen S, Mervaala E, Pasternack A, Ritvos O, Kivelä R, Hulmi JJ (2016) Systemic blockade of ACVR2B ligands prevents chemotherapy-induced muscle wasting by restoring muscle protein synthesis without affecting oxidative capacity or atrogenes. Sci Rep 6:32695.LEAK
OXPHOS
ETS
F
N
S
CIV
NS
ROX
HomogenateMouseSkeletal muscle
MiPNet21.12 Comparison mt respiration media2016
O2k-Protocols
O2k-MultiSensor: Mitochondrial respiration media for HRR and simultaneous O2k-Fluorometry.
LEAK
ROUTINE
OXPHOS
ETS
N
S
NS
ROX
Intact cells
Permeabilized cells
HumanHEK
Rackham 2016 Cell Rep2016Rackham O, Busch JD, Matic S, Siira SJ, Kuznetsova I, Atanassov I, Ermer JA, Shearwood AM, Richman TR, Stewart JB, Mourier A, Milenkovic D, Larsson NG, Filipovska A (2016) Hierarchical RNA processing is required for mitochondrial ribosome assembly. Cell Rep 16:1874-90.LEAK
OXPHOS
ETS
N
S
CIV
NS
Other combinations
Isolated mitochondriaMouseHeart
Stier 2016 Methods Ecol Evol2016Stier A, Romestaing C, Schull Q, Lefol E, Robin JP, Roussel D, Bize P (2016) How to measure mitochondrial function in birds using red blood cells: a case study in the king penguin and perspectives in ecology and evolution. Methods Ecol Evol doi:10.1111/2041-210X.12724.LEAK
ROUTINE
OXPHOS
ETS
N
S
ROX
Intact cellsBirdsSkeletal muscle
Blood cells
Scrima 2016 Biochim Biophys Acta2016Scrima R, Cela O, Merla G, Augello B, Rubino R, Quarato G, Fugetto S, Menga M, Fuhr L, Relógio A, Piccoli C, Mazzoccoli G, Capitanio N (2016) Clock-genes and mitochondrial respiratory activity: Evidence of a reciprocal interplay. Biochim Biophys Acta 1857:1344-51.LEAK
ROUTINE
ETS
ROXIntact cellsHumanLiver
Endothelial;epithelial;mesothelial cell
Other cell lines
Fibroblast
Witt 2016 Metab Brain Dis2016Witt AM, Larsen FS, Bjerring PN (2016) Accumulation of lactate in the rat brain during hyperammonaemia is not associated with impaired mitochondrial respiratory capacity. Metab Brain Dis [Epub ahead of print].LEAK
OXPHOS
ETS
N
S
NS
ROX
HomogenateRatNervous system
Baeder 2016 Int J Dent2016Baeder AC, Napa K, Richardson ST, Taylor OJ, Andersen SG, Wilcox SH, Winden DR, Reynolds PR, Bikman BT (2016) Oral gingival cell cigarette smoke exposure induces muscle cell metabolic disruption. Int J Dent 2016:2763160.LEAK
OXPHOS
ETS
N
NS
ROX
Permeabilized cellsMouseSkeletal muscle
Wijermars 2016 Am J Transplant2016Wijermars LG, Schaapherder AF, Kostidis S, Wüst RC, Lindeman JH (2016) Succinate accumulation and ischemia reperfusion injury: of mice but not men - A study in renal ischemia reperfusion. Am J Transplant 16:2741-6.LEAK
OXPHOS
ETS
N
S
NS
ROX
Permeabilized tissueHuman
Pig
Mouse
Rat
Kidney
Fisar 2016 Folia Biol (Praha)2016Fisar Z, Hroudova J (2016) Pig brain mitochondria as a biological model for study of mitochondrial respiration. Folia Biol (Praha) 62:15-25.LEAK
OXPHOS
ETS
N
S
NS
ROX
Isolated mitochondriaPigNervous system
Drehmer 2016 Stem Cell Res2016Drehmer DL, de Aguiar AM, Brandt AP, Petiz L, Cadena SM, Rebelatto CK, Brofman PR, Filipak Neto F, Dallagiovanna B, Abud AP (2016) Metabolic switches during the first steps of adipogenic stem cells differentiation. Stem Cell Res 17:413-421.LEAK
ROUTINE
ETS
ROXHumanFat
Stem cells
Lund 2016 J Physiol2016Lund MT, Kristensen M, Hansen M, Tveskov L, Floyd AK, Støckel M, Vainer B, Poulsen SS, Helge JW, Prats C, Dela F (2016) Hepatic mitochondrial oxidative phosphorylation is normal in obese patients with and without type 2 diabetes. J Physiol 594:4351-8.LEAK
OXPHOS
ETS
F
N
S
CIV
NS
ROX
Permeabilized tissueHumanLiver
Anand 2016 PLOS ONE2016Anand R, Strecker V, Urbach J, Wittig I, Reichert AS (2016) Mic13 is essential for formation of crista junctions in mammalian cells. PLOS ONE 11:e0160258.LEAK
ROUTINE
OXPHOS
ETS
N
CIV
NS
Other combinations
ROX
Intact cells
Permeabilized cells
HEK
Macheiner 2016 Sci Rep2016Macheiner T, Fengler VH, Agreiter M, Eisenberg T, Madeo F, Kolb D, Huppertz B, Ackbar R, Sargsyan K (2016) Magnetomitotransfer: An efficient way for direct mitochondria transfer into cultured human cells. Sci Rep 6:35571.LEAK
ROUTINE
ETS
ROXFibroblast
Bratic 2016 PLoS Genet2016Bratic A, Clemente P, Calvo-Garrido J, Maffezzini C, Felser A, Wibom R, Wedell A, Freyer C, Wredenberg A (2016) Mitochondrial polyadenylation is a one-step process required for mRNA integrity and tRNA maturation. PLoS Genet 12:e1006028.LEAK
OXPHOS
ETS
N
CIV
NS
Permeabilized tissueDrosophila
Amaral 2016 Biochim Biophys Acta2016Amaral AU, Cecatto C, da Silva JC, Wajner A, Godoy KD, Ribeiro RT, Wajner M (2016) cis-4-Decenoic and decanoic acids impair mitochondrial energy, redox and Ca2+ homeostasis and induce mitochondrial permeability transition pore opening in rat brain and liver: Possible implications for the pathogenesis of MCAD deficiency. Biochim Biophys Acta 1857:1363-72.LEAK
OXPHOS
ETS
NPermeabilized cells
Isolated mitochondria
RatNervous system
Liver
Chubanov 2016 Elife2016Chubanov V, Ferioli S, Wisnowsky A, Simmons DG, Leitzinger C, Einer C, Jonas W, Shymkiv Y, Bartsch H, Braun A, Akdogan B, Mittermeier L, Sytik L, Torben F, Jurinovic V, van der Vorst EP, Weber C, Yildirim ÖA, Sotlar K, Schürmann A, Zierler S, Zischka H, Ryazanov AG, Gudermann T (2016) Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival. Elife 5. pii: e20914.ROUTINE
ETS
ROXIntact cellsHumanFibroblast
Wang 2016 Toxicol Sci2016Wang L, Espinoza HM, MacDonald JW, Bammler TK, Williams CR, Yeh A, Louie KW, Marcinek DJ, Gallagher EP (2016) Olfactory Transcriptional Analysis of Salmon Exposed to Mixtures of Chlorpyrifos and Malathion Reveal Novel Molecular Pathways of Neurobehavioral Injury. Toxicol Sci 149:145-57.ETS
LEAK
OXPHOS
CIV
N
NS
ROX
S
Permeabilized tissueFishesEndothelial;epithelial;mesothelial cell
Lemieux 2016 Mitochondrion2016Lemieux H, Boemer F, van Galen G, Serteyn D, Amory H, Baise E, Cassart D, van Loon G, Marcillaud-Pitel C, Votion DM (2016) Mitochondrial function is altered in horse atypical myopathy. Mitochondrion 30:35-41.OXPHOS
ETS
N
S
NS
ROX
Permeabilized tissueHorseSkeletal muscle
Osiki 2016 FASEB J2016Osiki PO, Ojuka E, Marmaan G (2016) An investigation of the suitability of using octanoylcarnitine together with malate as a substrate combination for assessing Beta-oxidation using High Resolution Respirometry. FASEB J 30: 1015.12 .LEAK
OXPHOS
ETS
FPermeabilized tissueRatSkeletal muscle
Davuluri 2016 Proc Natl Acad Sci U S A2016Davuluri G, Song P, Liu Z, Wald D, Sakaguchi TF, Green MR, Devireddy L (2016) Inactivation of 3-hydroxybutyrate dehydrogenase 2 delays zebrafish erythroid maturation by conferring premature mitophagy. Proc Natl Acad Sci U S A 113:E1460-9.LEAK
ROUTINE
ETS
Intact cellsZebrafishBlood cells
Silva Ramos 2016 Biochim Biophys Acta2016Silva Ramos E, Larsson NG, Mourier A (2016) Bioenergetic roles of mitochondrial fusion. Biochim Biophys Acta 1857:1277-83.LEAK
OXPHOS
ETS
S
Gp
Permeabilized cellsMouseFibroblast
Yavari 2016 Cell Metab2016Yavari A, Stocker CJ, Ghaffari S, Wargent ET, Steeples V, Czibik G, Pinter K, Bellahcene M, Woods A, Martinez de Morentin PB, Cansell C, Lam BY, Chuster A, Petkevicius K, Nguyen-Tu MS, Martinez-Sanchez A, Pullen TJ, Oliver PL, Stockenhuber A, Nguyen C, Lazdam M, O'Dowd JF, Harikumar P, Toth M, Beall C, Kyriakou T, Parnis J, Sarma D, Katritsis G, Wortmann DD, Harper AR, Brown LA, Willows R, Gandra S, Poncio V, de Oliveira Figueiredo MJ, Qi NR, Peirson SN, McCrimmon RJ, Gereben B, Tretter L, Fekete C, Redwood C, Yeo GS, Heisler LK, Rutter GA, Smith MA, Withers DJ, Carling D, Sternick EB, Arch JR, Cawthorne MA, Watkins H, Ashrafian H (2016) Chronic activation of γ2 AMPK induces obesity and reduces β cell function. Cell Metab 23:821-36.LEAK
OXPHOS
ETS
N
NS
ROX
HomogenateMouseNervous system
Berschneider 2016 Thesis2016Berschneider K (2016) Connecting the functions of the proteasome and mitochondria in the lung. Dissertation p161.LEAK
ETS
ROXPermeabilized cellsHuman
Mouse
Lung;gill
Endothelial;epithelial;mesothelial cell
Fibroblast
Strifler 2016b PLOS ONE2016Strifler G, Tuboly E, Görbe A, Boros M, Pécz D, Hartmann P (2016) Targeting mitochondrial dysfunction with L-alpha glycerylphosphorylcholine. PLOS ONE 11:e0166682.LEAK
OXPHOS
ETS
N
S
NS
Other combinations
ROX
HomogenateRatLiver
Lores-Arnaiz 2016 Neurochem Res2016Lores-Arnaiz S, Lombardi P, Karadayian AG, Orgambide F, Cicerchia D, Bustamante J (2016) Brain cortex mitochondrial bioenergetics in synaptosomes and non-synaptic mitochondria during aging. Neurochem Res 41:353-63.LEAK
ROUTINE
OXPHOS
ETS
N
S
Intact cells
Isolated mitochondria
MouseNervous system
Queliconi 2016 PLOS ONE2016Queliconi BB, Kowaltowski AJ, Gottlieb RA (2016) Bicarbonate increases ischemia-reperfusion damage by inhibiting mitophagy. PLOS ONE 11:e0167678.LEAK
OXPHOS
ETS
S
ROX
RatHeart
Bynum 2016 Transfusion2016Bynum JA, Adam Meledeo M, Getz TM, Rodriguez AC, Aden JK, Cap AP, Pidcoke HF (2016) Bioenergetic profiling of platelet mitochondria during storage: 4°C storage extends platelet mitochondrial function and viability. Transfusion 56 Suppl 1:S76-84.LEAK
ROUTINE
ETS
ROXIntact cellsHumanBlood cells
Platelet
Van Zutphen 2016 J Hepatol2016van Zutphen T, Ciapaite J, Bloks VW, Ackereley C, Gerding A, Jurdzinski A, Allgayer de Moraes R, Zhang L, Wolters JC, Bischoff R, Wanders RJ, Houten SM, Bronte-Tinkew D, Shatseva T, Lewis GF, Groen AK, Reijngoud DJ, Bakker BM, Jonker JW, Kim PK, Bandsma RH (2016) Malnutrition-associated liver steatosis and ATP depletion is caused by peroxisomal and mitochondrial dysfunction. J Hepatol 65:1198-1208.ETS
LEAK
OXPHOS
F
N
NS
Other combinations
Isolated mitochondriaRatLiver
Hagl 2016 Neuromolecular Med2016Hagl S, Asseburg H, Heinrich M, Sus N, Blumrich EM, Dringen R, Frank J, Eckert GP (2016) Effects of long-term rice bran extract supplementation on survival, cognition and brain mitochondrial function in aged NMRI mice. Neuromolecular Med 18:347-63.LEAK
OXPHOS
ETS
N
S
CIV
NS
ROX
Isolated mitochondriaMouseNervous system
Jacobs 2016 J Physiol2016Jacobs RA, Lundby AM, Fenk S, Gehrig S, Siebenmann C, Flück D, Kirk N, Hilty MP, Lundby C (2016) Twenty-eight days of exposure to 3,454 m increases mitochondrial volume density in human skeletal muscle. J Physiol 594:1151-66.LEAK
OXPHOS
ETS
F
N
S
CIV
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Wolff 2016 J Evol Biol2016Wolff JN, Pichaud N, Camus MF, Côté G, Blier PU, Dowling DK (2016) Evolutionary implications of mitochondrial genetic variation: mitochondrial genetic effects on OXPHOS respiration and mitochondrial quantity change with age and sex in fruit flies. J Evol Biol 29:736-47.LEAK
OXPHOS
ETS
N
Gp
CIV
Other combinations
ROX
Permeabilized tissueDrosophilaSkeletal muscle
MiPNet21.13 Comparison mt-preparations2016
O2k-Protocols
O2k-Protocols: Mitochondrial preparations for HRR.
LEAK
OXPHOS
ETS
N
S
NS
ROX
Permeabilized cells
Homogenate
Isolated mitochondria
MouseHeart
Granata 2016 FASEB J2016Granata C, Oliveira RS, Little JP, Renner K, Bishop DJ (2016) Mitochondrial adaptations to high-volume exercise training are rapidly reversed after a reduction in training volume in human skeletal muscle. FASEB J 30:3413-23.LEAK
OXPHOS
ETS
N
S
CIV
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Mills 2016 Cell Metabol2016Mills KF, Yoshida S, Stein LR, Uchida K, Yoshino J, Imai SI (2016) Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice. Cell Metabol 24:1–12.OXPHOS
ETS
N
S
NS
Permeabilized tissueMouseSkeletal muscle
Cecatto 2016 Thesis2016Cecatto C (2016) Efeitos de acidos graxos hidroxilados de cadeia longa acumulados nas deficiencias da 3-hidroxiacil CoA desidrogenase de cadeia longa e da proteina trifunctional mitocondrial sobre a homeostase energetica mitochondrial nos musculos cardiaco e esqueletico de ratos jovens. Dissertation p103.LEAK
OXPHOS
ETS
NPermeabilized tissue
Isolated mitochondria
RatHeart
Skeletal muscle
Roy 2016 Free Radic Biol Med2016Roy J, Fauconnier J, Oger C, Farah C, Angebault-Prouteau C, Thireau J, Bideaux P, Scheuermann V, Bultel-Poncé V, Demion M, Galano JM, Durand T, Lee JC, Le Guennec JY (2016) Non-enzymatic oxidized metabolite of DHA, 4(RS)-4-F4t-neuroprostane protects the heart against reperfusion injury. Free Radic Biol Med 102:229-39.OXPHOS
ETS
N
S
NS
Permeabilized cellsRatHeart
Heinonen 2016 Hum Exp Toxicol2016Heinonen JA, Schramko AA, Skrifvars MB, Litonius E, Backman JT, Mervaala E, Rosenberg PH (2016) The effects of intravenous lipid emulsion on hemodynamic recovery and myocardial cell mitochondrial function after bupivacaine toxicity in anesthetized pigs. Hum Exp Toxicol [Epub ahead of print].LEAK
OXPHOS
ETS
F
N
S
NS
HomogenatePigHeart
Ojuka 2016 Am J Physiol Endocrinol Metab2016Ojuka E, Andrew B, Bezuidenhout N, George S, Maarman G, Madlala HP, Mendham A, Osiki PO (2016) Measurement of β-oxidation capacity of biological samples by respirometry: a review of principles and substrates. Am J Physiol Endocrinol Metab 310:E715-23.LEAK
OXPHOS
ETS
FPermeabilized tissue
Isolated mitochondria
Human
Mouse
Rat
Skeletal muscle
Liver
Amigo 2016 Aging Cell2016Amigo I, Menezes-Filho SL, Luévano-Martínez LA, Chausse B, Kowaltowski AJ (2016) Caloric restriction increases brain mitochondrial calcium retention capacity and protects against excitotoxicity. Aging Cell 16:73-81.LEAK
OXPHOS
ETS
N
S
Isolated mitochondriaNervous system
Johnson 2016 Diabetes2016Johnson ML, Distelmaier K, Lanza IR, Irving BA, Robinson MM, Konopka AR, Shulman GI, Nair KS (2016) Mechanism by which caloric restriction improves insulin sensitivity in sedentary obese adults. Diabetes 65:74-84.LEAK
OXPHOS
ETS
N
S
NS
ROX
Isolated mitochondriaHumanSkeletal muscle
Santos 2016 Insect Biochem Mol Biol2016Santos DE, Alberici LC, Hartfelder K (2016) Mitochondrial structure and dynamics as critical factors in honey bee (Apis mellifera L.) caste development. Insect Biochem Mol Biol 73:1-11.LEAK
OXPHOS
ETS
SPermeabilized tissueHexapodsFat
Peruzzo 2016 Cell Cycle2016Peruzzo P, Comelli M, Di Giorgio E, Franforte E, Mavelli I, Brancolini C (2016) Transformation by different oncogenes relies on specific metabolic adaptations. Cell Cycle 15:2656-68.LEAK
ROUTINE
ETS
ROXIntact cellsMouseFibroblast
Van Schaardenburgh 2016 PLOS ONE2016van Schaardenburgh M, Wohlwend M, Rognmo Ø, Mattsson EJ (2016) Mitochondrial respiration after one session of calf raise exercise in patients with peripheral vascular disease and healthy older adults. PLOS ONE 11:e0165038.ETS
LEAK
OXPHOS
F
N
NS
S
Permeabilized tissueHumanSkeletal muscle
Peyta 2016 Biochim Biophys Acta2016Peyta L, Jarnouen K, Pinault M, Guimaraes C, Pais de Barros JP, Chevalier S, Dumas JF, Maillot F, Hatch GM, Loyer P, Servais S (2016) Reduced cardiolipin content decreases respiratory chain capacities and increases ATP synthesis yield in the human HepaRG cells. Biochim Biophys Acta 1857:443-53.LEAK
OXPHOS
ETS
N
CIV
NS
ROX
Permeabilized cellsHumanLiver
Other cell lines
Schaefer 2016 PLOS ONE2016Schaefer PM, von Einem B, Walther P, Calzia E, von Arnim CA (2016) Metabolic characterization of intact cells reveals intracellular amyloid beta but not its precursor protein to reduce mitochondrial respiration. PLOS ONE 11:e0168157.LEAK
ROUTINE
ETS
CIV
ROX
Intact cellsHuman
Mouse
Nervous system
HEK
Doerrier 2016 Mitochondrion2016Doerrier C, García JA, Volt H, Díaz-Casado ME, Luna-Sánchez M, Fernández-Gil B, Escames G, López LC, Acuña-Castroviejo D (2016) Permeabilized myocardial fibers as model to detect mitochondrial dysfunction during sepsis and melatonin effects without disruption of mitochondrial network. Mitochondrion 27:56-63.LEAK
OXPHOS
ETS
N
S
NS
ROX
Permeabilized tissueMouseHeart
Lim 2016 FASEB J2016Lim SC, Hroudová J, Van Bergen NJ, Lopez Sanchez MI, Trounce IA, McKenzie M (2016) Loss of mitochondrial DNA-encoded protein ND1 results in disruption of complex I biogenesis during early stages of assembly. FASEB J 30:2236-48.OXPHOS
ETS
N
S
NS
ROX
Permeabilized cellsHumanOther cell lines
Gomez 2016 Thesis2016Gomez CR (2016) Mitochondrial responses to anoxia exposure in red eared sliders (Trachemys scripta). Master's Thesis p102.LEAK
OXPHOS
ETS
SPermeabilized cells
Isolated mitochondria
ReptilesHeart
Nervous system
LaBarge 2016 FASEB J2016LaBarge SA, Migdal CW, Buckner EH, Okuno H, Gertsman I, Stocks B, Barshop BA, Nalbandian SR, Philp A, McCurdy CE, Schenk S (2016) p300 is not required for skeletal muscle metabolic adaptation to endurance exercise training. FASEB J 30:1623-33.ETSF
N
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Bai 2016 PLOS ONE2016Bai F, Fink BD, Yu L, Sivitz WI (2016) Voltage-dependent regulation of Complex II energized mitochondrial oxygen flux. PLOS ONE 11:e0154982.LEAK
OXPHOS
ETS
N
S
CIV
NS
Isolated mitochondriaMouseHeart
Skeletal muscle
Nervous system
Liver
Galli 2016 Am J Physiol Regul Integr Comp Physiol2016Galli GL, Crossley J, Elsey RM, Dzialowski EM, Shiels HA, Crossley DA 2nd (2016) Developmental plasticity of mitochondrial function in American alligators, Alligator mississippiensis. Am J Physiol Regul Integr Comp Physiol 311:R1164-72.ETS
LEAK
OXPHOS
CIV
N
Other combinations
ROX
S
Isolated mitochondriaReptilesHeart
Briston 2016 Sci Rep2016Briston T, Lewis S, Koglin M, Mistry K, Shen Y, Hartopp N, Katsumata R, Fukumoto H, Duchen MR, Szabadkai G, Staddon JM, Roberts M, Powney B (2016) Identification of ER-000444793, a Cyclophilin D-independent inhibitor of mitochondrial permeability transition, using a high-throughput screen in cryopreserved mitochondria. Sci Rep 6:37798.LEAK
OXPHOS
ETS
N
S
ROX
Isolated mitochondriaRatLiver
Bastow 2016 J Cell Sci2016Bastow EL, Peswani AR, Tarrant DS, Pentland DR, Chen X, Morgan A, Staniforth GL, Tullet JM, Rowe ML, Howard MJ, Tuite MF, Gourlay CW (2016) New links between SOD1 and metabolic dysfunction from a yeast model of amyotrophic lateral sclerosis. J Cell Sci 129:4118-29.ETS
LEAK
ROUTINE
ROXSaccharomyces cerevisiae
Leucci 2016 Nature2016Leucci E, Vendramin R, Spinazzi M, Laurette P, Fiers M, Wouters J, Radaelli E, Eyckerman S, Leonelli C, Vanderheyden K, Rogiers A, Hermans E, Baatsen P, Aerts S, Amant F, Van Aelst S, van den Oord J, de Strooper B, Davidson I, Lafontaine DL, Gevaert K, Vandesompele J, Mestdagh P, Marine JC (2016) Melanoma addiction to the long non-coding RNA SAMMSON. Nature 531:518-22.LEAK
OXPHOS
ETS
N
CIV
NS
ROX
Permeabilized cellsHumanEndothelial;epithelial;mesothelial cell
Other cell lines
Camacho-Pereira 2016 Cell Metab2016Camacho-Pereira J, Tarragó MG, Chini CC, Nin V, Escande C, Warner GM, Puranik AS, Schoon RA, Reid JM, Galina A, Chini EN (2016) CD38 dictates age-related NAD decline and mitochondrial dysfunction through an SIRT3-dependent mechanism. Cell Metab 23:1127-39.ETS
LEAK
OXPHOS
ROUTINE
ROX
S
Intact cells
Isolated mitochondria
Human
Mouse
Liver
Lung;gill
Other cell lines
Hagl 2016 Nutr Neurosci2016Hagl S, Berressem D, Grewal R, Grebenstein N, Frank J, Eckert GP (2016) Rice bran extract improves mitochondrial dysfunction in brains of aged NMRI mice. Nutr Neurosci 19:1-10.LEAK
OXPHOS
ETS
N
S
CIV
NS
ROX
Isolated mitochondriaMouseNervous system
Ehinger 2016 Nat Commun2016Ehinger JK, Piel S, Ford R, Karlsson M, Sjövall F, Frostner EÅ, Morota S, Taylor RW, Turnbull DM, Cornell C, Moss SJ, Metzsch C, Hansson MJ, Fliri H, Elmér E (2016) Cell-permeable succinate prodrugs bypass mitochondrial complex I deficiency. Nat Commun 7:12317.OXPHOS
ETS
SIntact cells
Permeabilized tissue
Heart
Blood cells
Fibroblast
Khattar 2016 J Neurosci Methods2016Khattar NK, Yablonska S, Baranov SV, Baranova OV, Kretz ES, Larkin TM, Carlisle DL, Richardson RM, Friedlander RM (2016) Isolation of functionally active and highly purified neuronal mitochondria from human cortex. J Neurosci Methods 263:1-6.ETS
LEAK
OXPHOS
N
NS
Isolated mitochondriaHumanNervous system
Soendergaard 2016 Eur J Sport Sci2016Søndergård SD, Dela F, Helge JW, Larsen S (2016) Actovegin, a non-prohibited drug increases oxidative capacity in human skeletal muscle. Eur J Sport Sci 16:801-7.LEAK
OXPHOS
ETS
N
NS
Permeabilized tissueHumanSkeletal muscle
Snook 2016 Am J Physiol Regul Integr Comp Physiol2016Snook LA, MacPherson RE, Monaco CM, Frendo-Cumbo S, Castellani L, Peppler WT, Anderson ZG, Buzelle SL, LeBlanc PJ, Holloway GP, Wright DC (2016) Prior exercise training blunts short term highfat diet induced weight gain. Am J Physiol Regul Integr Comp Physiol 311:R315-24.LEAK
OXPHOS
ETS
N
NS
Permeabilized tissueMouseFat
Liu 2016 EMBO Mol Med2016Liu J, Liang X, Zhou D, Lai L, Xiao L, Liu L, Fu T, Kong Y, Zhou Q, Vega RB, Zhu MS, Kelly DP, Gao X, Gan Z (2016) Coupling of mitochondrial function and skeletal muscle fiber type by a miR-499/Fnip1/AMPK circuit. EMBO Mol Med 8:1212-1228.LEAK
OXPHOS
ETS
N
ROX
Permeabilized cells
Permeabilized tissue
MouseSkeletal muscle
Heimer 2016 Am J Hum Genet2016Heimer G, Kerätär JM, Riley LG, Balasubramaniam S, Eyal E, Pietikäinen LP, Hiltunen JK, Marek-Yagel D, Hamada J, Gregory A, Rogers C, Hogarth P, Nance MA, Shalva N, Veber A, Tzadok M, Nissenkorn A, Tonduti D, Renaldo F, Kraoua I, Panteghini C, Valletta L, Garavaglia B, Cowley MJ, Gayevskiy V, Roscioli T, Silberstein JM, Hoffmann C, Raas-Rothschild A, Tiranti V, Anikster Y, Christodoulou J, Kastaniotis AJ, Ben-Zeev B, Hayflick SJ (2016) MECR mutations cause childhood-onset dystonia and optic atrophy, a mitochondrial fatty acid synthesis disorder. Am J Hum Genet 99:1229-44.LEAK
ROUTINE
ETS
ROXIntact cellsHuman
Cecatto 2016 Toxicol In Vitro2016Cecatto C, Godoy KD, da Silva JC, Amaral AU, Wajner M (2016) Disturbance of mitochondrial functions provoked by the major long-chain 3-hydroxylated fatty acids accumulating in MTP and LCHAD deficiencies in skeletal muscle. Toxicol In Vitro 36:1-9.LEAK
OXPHOS
ETS
NPermeabilized tissue
Isolated mitochondria
RatHeart
Skeletal muscle
Lark 2016 Am J Physiol Cell Physiol2016Lark DS, Torres MJ, Lin CT, Ryan TE, Anderson EJ, Neufer PD (2016) Direct real-time quantification of mitochondrial oxidative phosphorylation efficiency in permeabilized skeletal muscle myofibers. Am J Physiol Cell Physiol 311:C239-45.LEAK
OXPHOS
ETS
N
Gp
NS
Permeabilized tissue
Isolated mitochondria
MouseSkeletal muscle
Ehinger 2016 Mov Disord2016Ehinger JK, Morota S, Hansson MJ, Gesine P, Elmér E (2016) Mitochondrial respiratory function in peripheral blood cells from Huntington’s disease patients. Mov Disord doi:10.1002/mdc3.12308.LEAK
ROUTINE
OXPHOS
ETS
N
S
CIV
NS
Other combinations
ROX
Intact cells
Permeabilized cells
HumanBlood cells
Lymphocyte
Platelet
Ryan 2016 J Mol Cell Cardiol2016Ryan TE, Schmidt CA, Alleman RJ, Tsang AM, Green TD, Neufer PD, Brown DA, McClung JM (2016) Mitochondrial therapy improves limb perfusion and myopathy following hindlimb ischemia. J Mol Cell Cardiol 97:191-6.LEAK
OXPHOS
ETS
N
S
CIV
NS
ROX
Isolated mitochondriaMouseSkeletal muscle
Berressem 2016 PLOS ONE2016Berressem D, Koch K, Franke N, Klein J, Eckert GP (2016) Intravenous treatment with a long-chain omega-3 lipid emulsion provides neuroprotection in a murine model of ischemic stroke - a pilot study. PLOS ONE 11:e0167329.LEAK
OXPHOS
ETS
N
S
CIV
Intact cellsMouseNervous system
Sirsat 2016 Biol Open2016Sirsat SK, Sirsat TS, Price ER, Dzialowski EM (2016) Post-hatching development of mitochondrial function, organ mass and metabolic rate in two ectotherms, the American alligator (Alligator mississippiensis) and the common snapping turtle (Chelydra serpentina). Biol Open 5:443-51.LEAK
OXPHOS
ETS
N
NS
Permeabilized tissueReptilesHeart
Skeletal muscle
Dias 2016 Neurobiol Aging2016Dias C, Lourenço CF, Ferreiro E, Barbosa RM, Laranjinha J, Ledo A (2016) Age-dependent changes in the glutamate-nitric oxide pathway in the hippocampus of the triple transgenic model of Alzheimer's disease: implications for neurometabolic regulation. Neurobiol Aging 46:84-95.LEAK
ETS
N
S
ROX
Permeabilized tissueMouseNervous system
Chen 2016 Nat Chem Biol2016Chen YJ, Mahieu NG, Huang X, Singh M, Crawford PA, Johnson SL, Gross RW, Schaefer J, Patti GJ (2016) Lactate metabolism is associated with mammalian mitochondria. Nat Chem Biol 12:937-43.LEAK
OXPHOS
ETS
N
NS
ROX
Isolated mitochondriaHumanHeLa
Li 2016 J Appl Physiol (1985)2016Li C, White SH, Warren LK, Wohlgemuth SE (2016) Effects of aging on mitochondrial function in skeletal muscle of quarter horses. J Appl Physiol (1985) 121:299-311.ETS
LEAK
OXPHOS
N
NS
ROX
Permeabilized tissueHorseSkeletal muscle
Tsai 2016 Sci Rep2016Tsai HH, Chang SC, Chou CH, Weng TP, Hsu CC, Wang JS (2016) Exercise training alleviates hypoxia-induced mitochondrial dysfunction in the lymphocytes of sedentary males. Sci Rep 6:35170.LEAK
ROUTINE
OXPHOS
ETS
F
N
S
NS
Other combinations
ROX
Intact cells
Permeabilized cells
HumanLymphocyte
Valenzuela 2016 Cell Death Dis2016Valenzuela R, Costa-Besada MA, Iglesias-Gonzalez J, Perez-Costas E, Villar-Cheda B, Garrido-Gil P, Melendez-Ferro M, Soto-Otero R, Lanciego JL, Henrion D, Franco R, Labandeira-Garcia JL (2016) Mitochondrial angiotensin receptors in dopaminergic neurons. Role in cell protection and aging-related vulnerability to neurodegeneration. Cell Death Dis 7:e2427.OXPHOS
ETS
NIsolated mitochondriaMouse
Rat
Nervous system
Shama 2016 Evol Appl2016Shama LNS, Mark FC, Strobel A, Lokmer A, John U, Wegner KM (2016) Transgenerational effects persist down the maternal line in marine sticklebacks: gene expression matches physiology in a warming ocean. Evol Appl 10013/epic.47323.LEAK
OXPHOS
ETS
NS
ROX
Permeabilized tissueFishesHeart
Rohlenova 2016 Antioxid Redox Signal2016Rohlenova K, Sachaphibulkij K, Stursa J, Bezawork-Geleta A, Blecha J, Endaya B, Werner L, Cerny J, Zobalova R, Goodwin J, Spacek T, Alisadeh E, Yan B, Nguyen M, Vondrusova M, Sobol M, Jezek P, Hozak P, Truksa J, Rohlena J, Dong L, Neuzil J (2016) Selective disruption of respiratory supercomplexes as a new strategy to suppress Her2high breast cancer. Antioxid Redox Signal 26:84-103.LEAK
ROUTINE
ETS
N
S
Other combinations
Permeabilized cells
Homogenate
Human
Mouse
Liver
Genital
Other cell lines
Scott 2016 Thesis2016Scott KY (2016) Evaluation of cardiac mitochondrial function in the fructose-fed rat. Master's Thesis p98.LEAK
OXPHOS
ETS
F
N
S
CIV
ROX
Isolated mitochondriaRatHeart
Keller 2016 Oxid Med Cell Longev2016Keller AC, Knaub LA, McClatchey PM, Connon CA, Bouchard R, Miller MW, Geary KE, Walker LA, Klemm DJ, Reusch JE (2016) Differential mitochondrial adaptation in primary vascular smooth muscle cells from a diabetic rat model. Oxid Med Cell Longev 2016:8524267.LEAK
OXPHOS
ETS
N
NS
Permeabilized cellsRatEndothelial;epithelial;mesothelial cell
Price 2016 J Thermal Biol2016Price ER, Sirsat TS, Sirsat SKG, Kang G, Keereetaweep J, Aziz M, Chapman KD, Dzialowski EM (2016) Thermal acclimation in American alligators: Effects of temperature regime on growth rate, mitochondrial function, and membrane composition. J Thermal Biol p11.LEAK
OXPHOS
ETS
N
S
CIV
NS
ROX
Permeabilized tissueReptilesHeart
Skeletal muscle
Xiong 2016 Hypertension2016Xiong S, Wang P, Ma L, Gao P, Gong L, Li L, Li Q, Sun F, Zhou X, He H, Chen J, Yan Z, Liu D, Zhu Z (2016) Ameliorating endothelial mitochondrial dysfunction restores coronary function via transient receptor potential vanilloid 1-mediated protein kinase A/uncoupling protein 2 pathway. Hypertension 67:451-60.LEAK
ROUTINE
OXPHOS
ETS
N
S
NS
ROX
Intact cells
Permeabilized cells
HumanEndothelial;epithelial;mesothelial cell
Other cell lines
Assmann 2016 Cell Rep2016Assmann N, Dettmer K, Simbuerger JM, Broeker C, Nuernberger N, Renner K, Courtneidge H, Klootwijk ED, Duerkop A, Hall A, Kleta R, Oefner PJ, Reichold M, Reinders J (2016) Renal fanconi syndrome is caused by a mistargeting-based mitochondriopathy. Cell Rep 15:1423-9.LEAK
OXPHOS
ETS
F
N
S
NS
Other combinations
ROX
Intact cellsPigKidney
Other cell lines
Timpani 2016 Neurotherapeutics2016Timpani CA, Trewin AJ, Stojanovska V, Robinson A, Goodman CA, Nurgali K, Betik AC, Stepto N, Hayes A, McConell GK, Rybalka E (2016) Attempting to compensate for reduced neuronal nitric oxide synthase protein with nitrate supplementation cannot overcome metabolic dysfunction but rather has detrimental effects in Dystrophin-deficient mdx muscle. Neurotherapeutics [Epub ahead of print].LEAK
OXPHOS
ETS
N
CIV
NS
Other combinations
ROX
Permeabilized tissueMouseSkeletal muscle
Cannon 2016 Lung2016Cannon DT, Liu J, Sakurai R, Rossiter HB, Rehan VK (2016) Impaired lung mitochondrial respiration following perinatal nicotine exposure in rats. Lung 194:325-8.LEAK
OXPHOS
ETS
N
S
CIV
NS
Permeabilized tissueRatLung;gill
Saben 2016 Cell Rep2016Saben JL, Boudoures AL, Asghar Z, Thompson A, Drury A, Zhang W, Chi M, Cusumano A, Scheaffer S, Moley KH (2016) Maternal metabolic syndrome programs mitochondrial dysfunction via germline changes across three generations. Cell Rep 16:1-8.LEAK
OXPHOS
ETS
N
NS
Permeabilized tissueMouseSkeletal muscle
Zabielski 2016 Diabetes2016Zabielski P, Lanza IR, Gopala S, Holtz Heppelmann CJ, Bergen HR 3rd, Dasari S, Nair KS (2016) Altered skeletal muscle mitochondrial proteome as the basis of disruption of mitochondrial function in diabetic mice. Diabetes 65:561-73.LEAK
OXPHOS
ETS
F
N
S
NS
ROX
Permeabilized cellsMouseSkeletal muscle
Wos 2016 Arch Biochem Biophys2016Woś M, Szczepanowska J, Pikuła S, Tylki-Szymańska A, Zabłocki K, Bandorowicz-Pikuła J (2016) Mitochondrial dysfunction in fibroblasts derived from patients with Niemann-Pick type C disease. Arch Biochem Biophys 593:50-9.LEAK
ETS
NIntact cellsHumanEndothelial;epithelial;mesothelial cell
Fibroblast
Siewiera 2016 Life Sci2016Siewiera K, Kassassir H, Talar M, Wieteska L, Watala C (2016) Higher mitochondrial potential and elevated mitochondrial respiration are associated with excessive activation of blood platelets in diabetic rats. Life Sci 148:293-304.LEAK
ROUTINE
ETS
ROXIntact cellsRatBlood cells
Platelet
MiPNet21.14 Reference sample HRR2016
O2k-Protocols
Development of a reference sample for HRR.
LEAK
ROUTINE
OXPHOS
ETS
F
N
S
Gp
CIV
NS
Other combinations
ROX
Intact cells
Permeabilized cells
HumanHEK
Brandt 2016 Chem Biol Interact2016Brandt AP, Gozzi GJ, Pires Ado R, Martinez GR, Dos Santos Canuto AV, Echevarria A, Di Pietro A, Cadena SM (2016) Impairment of oxidative phosphorylation increases the toxicity of SYD-1 on hepatocarcinoma cells (HepG2). Chem Biol Interact 256:154-60.LEAK
ROUTINE
ETS
ROXIntact cellsHumanLiver
Other cell lines
Castellano-Gonzalez 2016 Oncotarget2016Castellano-González G, Pichaud N, Ballard JW, Bessede A, Marcal H, Guillemin GJ (2016) Epigallocatechin-3-gallate induces oxidative phosphorylation by activating cytochrome c oxidase in human cultured neurons and astrocytes. Oncotarget 7:7426-40LEAK
ROUTINE
ETS
ROXIntact cellsHumanNervous system
Sheremet 2016 Biochemistry (Moscow)2016Sheremet NL, Nevinitsyna TA, Zhorzholadze NV, Ronzina IA, Itkis YS, Krylova TD, Tsygankova PG, Malakhova VA, Zakharova EY, Tokarchuk AV, Panteleeva AA, Karger EM, Lyamzaev KG, Avetisov SE (2016) Previously unclassified mutation of mtDNA m.3472T>C: evidence of pathogenicity in Leber’s hereditary optic neuropathy. Biochemistry (Moscow) BM16-078.LEAK
ROUTINE
OXPHOS
ETS
N
S
NS
ROX
Intact cells
Permeabilized cells
HumanEndothelial;epithelial;mesothelial cell
Fibroblast
Platelet
Baris 2016 Am J Physiol Regul Integr Comp Physiol2016Baris TZ, Blier PU, Pichaud N, Crawford DL, Oleksiak MF (2016) Gene by environmental interactions affecting oxidative phosphorylation and thermal sensitivity. Am J Physiol Regul Integr Comp Physiol 311:R157-65.LEAK
OXPHOS
ETS
CIV
NS
ROX
Permeabilized tissueFishesHeart
Sparks 2016 Diabetologia2016Sparks LM, Gemmink A, Phielix E, Bosma M, Schaart G, Moonen-Kornips E, Jörgensen JA, Nascimento EB, Hesselink MK, Schrauwen P, Hoeks J (2016) ANT1-mediated fatty acid-induced uncoupling as a target for improving myocellular insulin sensitivity. Diabetologia 59:1030-9.LEAK
OXPHOS
ETS
F
N
NS
Other combinations
Permeabilized tissue
Isolated mitochondria
Human
Mouse
Rat
Skeletal muscle
Other cell lines
Zhunussova 2016 PLOS ONE2016Zhunussova A, Vitol EA, Polyak B, Tuleukhanov S, Brooks AD, Sensenig R, Friedman G, Orynbayeva Z (2016) Mitochondria-mediated anticancer effects of non-thermal atmospheric plasma. PLOS ONE 11:e0156818.LEAK
ROUTINE
ETS
Intact cellsHumanGenital
Other cell lines
Cacabelos 2016 Acta Neuropathol Commun2016Cacabelos D, Ramírez-Núñez O, Granado-Serrano AB, Torres P, Ayala V, Moiseeva V, Povedano M, Ferrer I, Pamplona R, Portero-Otin M, Boada J (2016) Early and gender-specific differences in spinal cord mitochondrial function and oxidative stress markers in a mouse model of ALS. Acta Neuropathol Commun 4:3.LEAK
ROUTINE
OXPHOS
ETS
N
S
NS
ROX
Intact cells
Permeabilized tissue
MouseNervous system
Other cell lines
Lesage 2016 Am J Hum Genet2016Lesage S, Drouet V, Majounie E, Deramecourt V, Jacoupy M, Nicolas A, Cormier-Dequaire F, Hassoun SM, Pujol C, Ciura S, Erpapazoglou Z, Usenko T, Maurage CA, Sahbatou M, Liebau S, Ding J, Bilgic B, Emre M, Erginel-Unaltuna N, Guven G, Tison F, Tranchant C, Vidailhet M, Corvol JC, Krack P, Leutenegger AL, Nalls MA, Hernandez DG, Heutink P, Gibbs JR, Hardy J, Wood NW, Gasser T, Durr A, Deleuze JF, Tazir M, Destée A, Lohmann E, Kabashi E, Singleton A, Corti O, Brice A (2016) Loss of VPS13C function in autosomal-recessive parkinsonism causes mitochondrial dysfunction and increases PINK1/Parkin-Dependent Mitophagy. Am J Hum Genet 98:500-13.LEAK
ROUTINE
ETS
ROXIntact cellsOther mammalsKidney
Other cell lines
Christensen 2016 J Appl Physiol (1985)2016Christensen PM, Jacobs RA, Bonne T, Flück D, Bangsbo J, Lundby C (2016) A short period of high-intensity interval training improves skeletal muscle mitochondrial function and pulmonary oxygen uptake kinetics. J Appl Physiol (1985) 120:1319-27.LEAK
OXPHOS
ETS
F
N
S
CIV
NS
Other combinations
ROX
Permeabilized tissueHumanSkeletal muscle
Du 2016 Thesis2016Du X (2016) Anthropogenic pollution effects on mitochondrial energy metabolism, gene expression, and genotypes of natural Fundulus heteroclitus populations. Dissertation p175.LEAK
ROUTINE
OXPHOS
ETS
S
CIV
Other combinations
ROX
FishesLiver
Tunholi 2016 J Invertebr Pathol2016Tunholi VM, Tunholi-Alves VM, Santos AT, Garcia Jda S, Maldonado A Jr, da-Silva WS, Rodrigues Mde L, Pinheiro J (2016) Evaluation of the mitochondrial system in the gonad-digestive gland complex of Biomphalaria glabrata (Mollusca, Gastropoda) after infection by Echinostoma paraensei (Trematoda, Echinostomatidae). J Invertebr Pathol 136:136-41.LEAK
OXPHOS
ETS
N
NS
ROX
Permeabilized tissueMolluscsGenital
Kilbaugh 2016 Mitochondrion2016Kilbaugh TJ, Karlsson M, Duhaime AC, Hansson MJ, Elmer E, Margulies SS (2016) Mitochondrial response in a toddler-aged swine model following diffuse non-impact traumatic brain injury. Mitochondrion 26:19-25.LEAK
OXPHOS
ETS
N
S
CIV
NS
ROX
HomogenatePigNervous system
Szczepanowska 2016 EMBO J2016Szczepanowska K, Maiti P, Kukat A, Hofsetz E, Nolte H, Senft K, Becker C, Ruzzenente B, Hornig-Do HT, Wibom R, Wiesner RJ, Krüger M, Trifunovic A (2016) CLPP coordinates mitoribosomal assembly through the regulation of ERAL1 levels. EMBO J 35:2566-83.LEAK
OXPHOS
ETS
N
NS
Isolated mitochondriaMouseHeart
Holandino 2016 Bioelectrochemistry2016Holandino C, Teixeira CA, de Oliveira FA, Barbosa GM, Siqueira CM, Messeder DJ, de Aguiar FS, da Veiga VF, Girard-Dias W, Miranda K, Galina A, Capella MA, Morales MM (2016) Direct electric current treatment modifies mitochondrial function and lipid body content in the A549 cancer cell line. Bioelectrochemistry 111:83-92.LEAK
ROUTINE
ETS
ROXIntact cellsHumanLung;gill
Other cell lines
ETS capacity2016Gnaiger E (2016) Why ETS capacity, why not State 3u? Mitochondr Physiol Network 2014-07-06, edited 2016-11-07, 2017-02-17.ETS
Gemmink 2016 Diabetologia2016Gemmink A, Bosma M, Kuijpers HJ, Hoeks J, Schaart G, van Zandvoort MA, Schrauwen P, Hesselink MK (2016) Decoration of intramyocellular lipid droplets with PLIN5 modulates fasting-induced insulin resistance and lipotoxicity in humans. Diabetologia 59:1040-8.ETS
OXPHOS
F
NS
Other combinations
Permeabilized tissueHumanSkeletal muscle
Grundmanova 2016 Physiol Res2016Grundmanová M, Jarkovská D, Süß A, Tůma Z, Marková M, Grundman Z, El-Kadi A, Čedíková M, Štengl M, Kuncová J (2016) Propofol-induced mitochondrial and contractile dysfunction of the rat ventricular myocardium. Physiol Res 65:S601-9.LEAK
OXPHOS
ETS
N
S
CIV
NS
ROX
Permeabilized tissueRatHeart
Schoepf 2016 FEBS J2016Schöpf B, Schäfer G, Weber A, Talasz H, Eder IE, Klocker H, Gnaiger E (2016) Oxidative phosphorylation and mitochondrial function differ between human prostate tissue and cultured cells. FEBS J 283:2181-96.LEAK
OXPHOS
ETS
F
N
S
NS
Other combinations
ROX
Permeabilized cells
Permeabilized tissue
HumanEndothelial;epithelial;mesothelial cell
Genital
Other cell lines
Fibroblast
Jiroutkova 2016 JPEN J Parenter Enteral Nutr2016Jiroutková K, Krajčová A, Žiak J, Fric M, Gojda J, Džupa V, Kalous M, Tůmová J, Trnka J, Duška F (2016) Mitochondrial function in an in vitro model of skeletal muscle of patients with protracted critical illness and intensive care unit-acquired weakness. JPEN J Parenter Enteral Nutr [Epub ahead of print].LEAK
ETS
F
ROX
HumanSkeletal muscle
Other cell lines
Davuluri 2016 J Physiol2016Davuluri G, Allawy A, Thapaliya S, Rennison JH, Singh D, Kumar A, Sandlers Y, Van Wagoner DR, Flask CA, Hoppel C, Kasumov T, Dasarathy S (2016) Hyperammonaemia-induced skeletal muscle mitochondrial dysfunction results in cataplerosis and oxidative stress. J Physiol 594:7341-60.LEAK
ETS
ROXIntact cellsMouseSkeletal muscle
Cheng 2016 Nat Immunol2016Cheng SC, Scicluna BP, Arts RJ, Gresnigt MS, Lachmandas E, Giamarellos-Bourboulis EJ, Kox M, Manjeri GR, Wagenaars JA, Cremer OL, Leentjens J, van der Meer AJ, van de Veerdonk FL, Bonten MJ, Schultz MJ, Willems PH, Pickkers P, Joosten LA, van der Poll T, Netea MG (2016) Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis. Nat Immunol 17:406-13.LEAK
ROUTINE
ETS
ROXIntact cellsHumanBlood cells
Lymphocyte
Karlsson 2016 Shock2016Karlsson M, Hara N, Morata S, Sjövall F, Kilbaugh T, Hansson MJ, Uchino H, Elmér E (2016) Diverse and tissue-specific mitochondrial respiratory response in a mouse model of sepsis-induced multiple organ failure. Shock 45:404-10.LEAK
OXPHOS
ETS
N
S
CIV
NS
HomogenateMouseNervous system
Liver
Lukasiak 2016 Eur J Pharmacol2016Łukasiak A, Skup A, Chlopicki S, Łomnicka M, Kaczara P, Proniewski B, Szewczyk A, Wrzosek A (2016) SERCA, complex I of the respiratory chain and ATP-synthase inhibition are involved in pleiotropic effects of NS1619 on endothelial cells. Eur J Pharmacol 786:137-47.LEAK
ETS
Other combinationsPermeabilized cellsHumanEndothelial;epithelial;mesothelial cell
Radovic 2016 Diabetologia2016Radović B, Vujić N, Leopold C, Schlager S, Goeritzer M, Patankar JV, Korbelius M, Kolb D, Reindl J, Wegscheider M, Tomin T, Birner-Gruenberger R, Schittmayer M, Groschner L, Magnes C, Diwoky C, Frank S, Steyrer E, Du H, Graier WF, Madl T, Kratky D (2016) Lysosomal acid lipase regulates VLDL synthesis and insulin sensitivity in mice. Diabetologia 59:1743-52.LEAK
OXPHOS
ETS
N
S
NS
Isolated mitochondriaMouseLiver
MiPNet17.03 Shredder vs Fibres2015-06-18
O2k-Protocols
Mitochondrial respiration in permeabilized fibres versus homogenate from fish liver and heart. An application study with the PBI-Shredder.
LEAK
OXPHOS
ETS
N
S
NS
HomogenateFishesHeart
Liver
MiPNet18.05 Amplex-Mouse-heart2015-06-16
O2k-Protocols
O2k-Fluorometry: HRR and H2O2 production in mouse cardiac tissue homogenate.
LEAK
OXPHOS
ETS
N
S
NS
HomogenateMouseHeart
MiPNet20.13 Safranin mt-membranepotential2015-06-15
O2k-Protocols
O2k-Fluorometry: HRR and simultaneous determination of mt-membrane potential with safranin.
LEAK
ETS
S
ROX
HomogenateMouseNervous system
MiPNet20.14 AmplexRed H2O2-production2015-06-15
O2k-Protocols
O2k-Fluorometry: HRR and simultaneous determination of H2O2 production with Amplex Red.
LEAK
OXPHOS
ETS
SIsolated mitochondriaMouseHeart
MiPNet18.06 Amplex-Yeast2015-06-15
O2k-Protocols
O2k-Fluorometry: Amplex® UltraRed using freeze-dried baker’s yeast.
ROUTINE
ETS
Intact cellsSaccharomyces cerevisiae
Fungi
Kelly 2015 Biotechnol J2015Kelly PS, Breen L, Gallagher C, Kelly S, Henry M, Lao NT, Meleady P, O'Gorman D, Clynes M, Barron N (2015) Re-programming CHO cell metabolism using miR-23 tips the balance towards a highly productive phenotype. Biotechnol J 10:1029-40.LEAK
ROUTINE
OXPHOS
ETS
N
S
CIV
NS
ROX
Intact cells
Permeabilized cells
CHO
Ruiz-Perez 2015 J Biol Chem2015Ruiz-Pérez MV, Medina MÁ, Urdiales JL, Keinänen TA, Sánchez-Jiménez F (2015) Polyamine metabolism is sensitive to glycolysis inhibition in human neuroblastoma cells. J Biol Chem 290:6106-19.LEAK
ROUTINE
ETS
ROXIntact cellsHumanNervous system
Other cell lines
Neuroblastoma
Hwang 2015 EMBO Mol Med2015Hwang S, Disatnik MH, Mochly-Rosen D (2015) Impaired GAPDH-induced mitophagy contributes to the pathology of Huntington's disease. EMBO Mol Med 7:1307-26.LEAK
OXPHOS
ETS
ROXIntact cellsRatNervous system
Other cell lines
Patil 2015 J Nutr Biochem2015Patil YN, Dille KN, Burk DH, Cortez CC, Gettys TW (2015) Cellular and molecular remodeling of inguinal adipose tissue mitochondria by dietary methionine restriction. J Nutr Biochem 26:1235-47.LEAK
OXPHOS
ETS
F
N
S
Gp
ROX
Isolated mitochondriaMouseSkeletal muscle
Liver
Fat
Cell ergometry2015Gnaiger E (2015) Cell ergometry and OXPHOS. Mitochondr Physiol Network 2015-01-18.LEAK
OXPHOS
ETS
N
S
NS
ROX
Moore 2015 PhD Thesis2015Moore D (2015) Biostabilization of lipid bilayers: dealing with water stress in embryos of Artemia franciscana. PhD Thesis 1-111.LEAK
OXPHOS
ETS
SIsolated mitochondriaRatLiver
Grabez 2015 J Anim Sci2015Grabež V, Kathri M, Phung V, Moe KM, Slinde E, Skaugen M, Saarem K, Egelandsdal B (2015) Protein expression and oxygen consumption rate of early postmortem mitochondria relate to meat tenderness. J Anim Sci 93:1967-79.LEAK
OXPHOS
ETS
F
N
S
NS
Other combinations
ROX
Permeabilized tissueBovinesSkeletal muscle
Ramos-Filho 2015 PLoS One2015Ramos-Filho D, Chicaybam G, de-Souza-Ferreira E, Guerra Martinez C, Kurtenbach E, Casimiro-Lopes G, Galina A (2015) High intensity interval training (HIIT) induces specific changes in respiration and electron leakage in the mitochondria of different rat skeletal muscles. PLoS One 10:e0131766.LEAK
OXPHOS
ETS
F
N
S
Gp
NS
ROX
Permeabilized tissueRatSkeletal muscle
Gnaiger 2015 Scand J Med Sci Sports2015Gnaiger E, Boushel R, Søndergaard H, Munch-Andersen T, Damsgaard R, Hagen C, Díez-Sánchez C, Ara I, Wright-Paradis C, Schrauwen P, Hesselink M, Calbet JAL, Christiansen M, Helge JW, Saltin B (2015) Mitochondrial coupling and capacity of oxidative phosphorylation in skeletal muscle of Inuit and caucasians in the arctic winter. Scand J Med Sci Sports 25 (Suppl 4):126–34.ETS
LEAK
OXPHOS
F
N
ROX
S
Permeabilized tissueHumanSkeletal muscle
Bock 2015 Thesis2015Bock UB (2015) Auswirkung von normobarer Hyperoxie auf die mitochondriale Atmung von Alveolarmakrophagen. Dissertation p80.LEAK
ROUTINE
OXPHOS
ETS
N
S
CIV
NS
ROX
Intact cells
Permeabilized cells
MouseLung;gill
Macrophage-derived
Orynbayeva 2015 Nanomedicine (Lond)2015Orynbayeva Z, Sensenig R, Polyak B (2015) Metabolic and structural integrity of magnetic nanoparticle-loaded primary endothelial cells for targeted cell therapy. Nanomedicine (Lond) 10:1555-68.LEAK
ROUTINE
ETS
ROXIntact cellsRatEndothelial;epithelial;mesothelial cell
Roy Chowdhury 2015 Biosci Rep2015Roy Chowdhury SK, Djordjevic J, Albensi B, Fernyhough P (2015) Simultaneous evaluation of substrate-dependent oxygen consumption rates and mitochondrial membrane potential by TMRM and safranin in cortical mitochondria. Biosci Rep 36.LEAK
OXPHOS
ETS
N
S
NS
ROX
Homogenate
Isolated mitochondria
MouseNervous system
Schoettl 2015 Mol Metab2015Schöttl T, Kappler L, Fromme T, Klingenspor M (2015) Limited OXPHOS capacity in white adipocytes is a hallmark of obesity in laboratory mice irrespective of the glucose tolerance status. Mol Metab 4:631-42.LEAK
ROUTINE
OXPHOS
ETS
F
N
S
ROX
Intact cells
Isolated mitochondria
MouseFat
Other cell lines
Hendricks 2015 Thesis2015Hendricks EW (2015) The impact of aging and estrogen therapy on synaptic mitochondrial bioenergetics in an Alzheimer's mouse model. Master Thesis 1-67.LEAK
ROUTINE
OXPHOS
ETS
N
S
NS
ROX
Intact cells
Permeabilized cells
Isolated mitochondria
MouseNervous system
Cassina 2015 Biol Reprod2015Cassina AM, Silveira P, Cantu L, Montes JM, Radi R, Sapiro R (2015) Defective Human sperm cells are associated with mitochondrial dysfunction and oxidant production. Biol Reprod 93:119.LEAK
ROUTINE
ETS
ROXHumanGenital
Christiansen 2015 Am J Physiol Heart Circ Physiol2015Christiansen LB, Dela F, Koch J, Hansen CN, Leifsson PS, Yokota T (2015) Impaired cardiac mitochondrial oxidative phosphorylation and enhanced mitochondrial oxidative stress in feline hypertrophic cardiomyopathy. Am J Physiol Heart Circ Physiol 308:H1237-47.LEAK
OXPHOS
ETS
F
N
S
CIV
NS
ROX
Permeabilized tissue
Isolated mitochondria
CatHeart
Skeletal muscle
Park 2015 Proc Natl Acad Sci USA2015Park JH, Kang HJ, Lee YK, Kang H, Kim J, Chung JH, Chang JS, McPherron AC, Lee SB (2015) Inactivation of EWS reduces PGC-1α protein stability and mitochondrial homeostasis. Proc Natl Acad Sci USA 112:6074-9.LEAK
ROUTINE
ETS
ROXIntact cellsMouseFat
Burtscher 2015 Mitochondrion2015Burtscher J, Zangrandi L, Schwarzer C, Gnaiger E (2015) Differences in mitochondrial function in homogenated samples from healthy and epileptic specific brain tissues revealed by high-resolution respirometry. Mitochondrion 25:104-12.LEAK
OXPHOS
ETS
N
S
CIV
NS
ROX
Permeabilized tissue
Homogenate
MouseNervous system
Kishita 2015 Am J Hum Genet2015Kishita Y, Pajak A, Bolar NA, Marobbio CM, Maffezzini C, Miniero DV, Monné M, Kohda M, Stranneheim H, Murayama K, Naess K, Lesko N, Bruhn H, Mourier A, Wibom R, Nennesmo I, Jespers A, Govaert P, Ohtake A, Van Laer L, Loeys BL, Freyer C, Palmieri F, Wredenberg A, Okazaki Y, Wedell A (2015) Intra-mitochondrial methylation deficiency due to mutations in SLC25A26. Am J Hum Genet 97:761-8.OXPHOS
ETS
N
NS
HumanSkeletal muscle
Fibroblast
Duicu 2015 Biomed Res Int2015Duicu OM, Lighezan R, Sturza A, Ceausu RA, Borza C, Vaduva A, Noveanu L, Gaspar M, Ionac A, Feier H, Muntean DM, Mornos C (2015) Monoamine oxidases as potential contributors to oxidative stress in diabetes: time for a study in patients undergoing heart surgery. Biomed Res Int 2015:515437.LEAK
OXPHOS
ETS
N
S
ROX
Permeabilized tissueHumanHeart
Tan 2015 Cell Metab2015Tan AS, Baty JW, Dong L, Bezawork-Geleta A, Endaya B, Goodwin J, Bajzikova M, Kovarova J, Peterka M, Yan B, Pesdar EA, Sobol M, Filimonenko A, Stuart S, Vondrusova M, Kluckova K, Sachaphibulkij K, Rohlena J, Hozak P, Truksa J, Eccles D, Haupt LM, Griffiths LR, Neuzil J, Berridge MV (2015) Mitochondrial genome acquisition restores respiratory function and tumorigenic potential of cancer cells without mitochondrial DNA. Cell Metab 21:81-94.LEAK
ROUTINE
OXPHOS
ETS
N
S
NS
ROX
Intact cells
Permeabilized cells
Isolated mitochondria
Human
Mouse
Endothelial;epithelial;mesothelial cell
Genital
Other cell lines
Sundstroem 2015 PhD Thesis2015Sundstrøm T (2015) Experimental modeling and novel therapeutic strategies in melanoma brain metastasis. PhD Thesis 1-146.ETSN
S
NS
ROX
MouseNervous system
Hollis 2015 Proc Natl Acad Sci U S A2015Hollis F, van der Kooij MA, Zanoletti O, Lozano L, Cantó C, Sandi C (2015) Mitochondrial function in the brain links anxiety with social subordination. Proc Natl Acad Sci U S A 112:15486-91.OXPHOS
ETS
N
S
NS
ROX
HomogenateRatNervous system
Aroor 2015 Diabetes2015Aroor AR, Habibi J, Ford DA, Nistala R, Lastra G, Manrique C, Dunham MM, Ford KD, Thyfault JP, Parks EJ, Sowers JR, Rector RS (2015) Dipeptidyl peptidase-4 inhibition ameliorates western diet-induced hepatic steatosis and insulin resistance through hepatic lipid remodeling and modulation of hepatic mitochondrial function. Diabetes 64:1988-2001.ETS
LEAK
OXPHOS
ROUTINE
F
N
NS
S
Isolated mitochondriaMouseLiver
Six 2015 Cell Death Dis2015Six E, Lagresle-Peyrou C, Susini S, De Chappedelaine C, Sigrist N, Sadek H, Chouteau M, Cagnard N, Fontenay M, Hermine O, Chomienne C, Reynier P, Fischer A, André-Schmutz I, Gueguen N, Cavazzana M (2015) AK2 deficiency compromises the mitochondrial energy metabolism required for differentiation of human neutrophil and lymphoid lineages. Cell Death Dis 6:e1856.LEAK
ROUTINE
ETS
ROXIntact cellsHumanBlood cells
Other cell lines
Venter 2015 J Clin Cell Immunol2015Venter G, Wijers M, Oerlemans FTJJ, Manjeri G, Fransen JAM, Wieringa B (2015) Glycolytic metabolism is differentially coupled to proliferative potential and morphodynamic capacity in RAW 264.7 and Mafb/C-Maf deficient macrophage lineages. J Clin Cell Immunol 6:1-11.LEAK
ROUTINE
ETS
ROXMouseBlood cells
Macrophage-derived
Ofer 2015 Mol Endocrinol2015Ofer P, Heidegger I, Eder IE, Schöpf B, Neuwirt H, Geley S, Klocker H, Massoner P (2015) Both IGF1R and INSR knockdown exert anti-tumorigenic effects in prostate cancer in vitro and in vivo. Mol Endocrinol 29:1694-707.ROUTINE
OXPHOS
ETS
F
N
NS
Intact cells
Permeabilized cells
HumanGenital
Other cell lines
Luevano-Martinez 2015 Biochim Biophys Acta2015Luévano-Martínez LA, Forni MF, Dos Santos VT, Souza-Pinto NC, Kowaltowski AJ (2015) Cardiolipin is a key determinant for mtDNA stability and segregation during mitochondrial stress. Biochim Biophys Acta 1847:587-98.ROUTINE
ETS
ROXIntact cellsSaccharomyces cerevisiae
Fungi
Dahl 2015 Acta Physiol (Oxf)2015Dahl R, Larsen S, Dohlmann TL, Qvortrup K, Helge JW, Dela F, Prats C (2015) Three dimensional reconstruction of the human skeletal muscle mitochondrial network as a tool to assess mitochondrial content and structural organization. Acta Physiol (Oxf) 213:145-55.LEAK
OXPHOS
ETS
N
CIV
NS
Permeabilized tissueHumanSkeletal muscle
Schwarzkopf 2015 Neuroscience2015Schwarzkopf TM, Koch K, Klein J (2015) Reduced severity of ischemic stroke and improvement of mitochondrial function after dietary treatment with the anaplerotic substance triheptanoin. Neuroscience 300:201-9.LEAK
OXPHOS
ETS
N
S
CIV
NS
ROX
Isolated mitochondriaMouseNervous system
Kuznetsov 2015 Biochim Biophys Acta2015Kuznetsov AV, Javadov S, Sickinger S, Frotschnig S, Grimm M (2014) H9c2 and HL-1 cells demonstrate distinct features of energy metabolism, mitochondrial function and sensitivity to hypoxia-reoxygenation. Biochim Biophys Acta 1853:276-84.ROUTINE
ETS
Intact cellsRatHeart
Other cell lines
Du 2015 Aquat Toxicol2015Du X, Crawford DL, Oleksiak MF (2015) Effects of anthropogenic pollution on the oxidative phosphorylation pathway of hepatocytes from natural populations of Fundulus heteroclitus. Aquat Toxicol 165:231-40.LEAK
OXPHOS
ETS
N
S
CIV
ROX
Permeabilized cellsFishesLiver
Victorino 2015 Tumour Biol2015Victorino VJ, Barroso WA, Assunção AK, Cury V, Jeremias IC, Petroni R, Chausse B, Ariga SK, Herrera AC, Panis C, Lima TM, Souza HP (2015) PGC-1β regulates HER2-overexpressing breast cancer cells proliferation by metabolic and redox pathways. Tumour Biol 37:6035-44.LEAK
ROUTINE
ETS
ROXIntact cellsHumanGenital
Other cell lines
Fritsch 2015 Am J Clin Nutr2015Fritsch M, Koliaki C, Livingstone R, Phielix E, Bierwagen A, Meisinger M, Jelenik T, Strassburger K, Zimmermann S, Brockmann K, Wolff C, Hwang JH, Szendroedi J, Roden M (2015) Time course of postprandial hepatic phosphorus metabolites in lean, obese, and type 2 diabetes patients. Am J Clin Nutr 102:1051-8.OXPHOS
ETS
N
NS
HumanSkeletal muscle
Irving 2015 J Clin Endocrinol Metab2015Irving BA, Lanza IR, Henderson GC, Rao RR, Spiegelman BM, Nair KS (2015) Combined training enhances skeletal muscle mitochondrial oxidative capacity independent of age. J Clin Endocrinol Metab 100:1654-63.LEAK
OXPHOS
ETS
N
S
NS
Isolated mitochondriaHumanSkeletal muscle
Imran 2015 J Neurochem2015Imran I, Hillert MH, Klein J (2015) Early metabolic responses to lithium/pilocarpine-induced status epilepticus in rat brain. J Neurochem 135:1007-18.LEAK
OXPHOS
ETS
N
S
CIV
NS
ROX
Isolated mitochondriaRatNervous system
Boutant 2015 Mol Metab2015Boutant M, Joffraud M, Kulkarni SS, Garcia-Casarrubios E, Garcia-Roves PM, Ratajczak J, Fernandez-Marcos PJ, Valverde AM, Serrano M, Canto C (2015) SIRT1 enhances glucose tolerance by potentiating brown adipose tissue function. Mol Metab 4:118-31.ETS
LEAK
OXPHOS
N
NS
ROX
S
Homogenate
Permeabilized tissue
MouseFat
Liver
Skeletal muscle
Hansen 2015 Obesity (Silver Spring)2015Hansen M, Lund MT, Gregers E, Kraunsøe R, Van Hall G, Helge JW, Dela F (2015) Adipose tissue mitochondrial respiration and lipolysis before and after a weight loss by diet and RYGB. Obesity (Silver Spring) 23:2022-9.LEAK
OXPHOS
ETS
F
N
NS
Permeabilized tissueHumanFat
Sobotka 2015 Physiol Res2015Sobotka O, Drahota Z, Kučera O, Endlicher R, Rauchová H, Červinková Z (2015) The effect of α-tocopheryl succinate on succinate respiration in rat liver mitochondria. Physiol Res 64 Suppl 5:S609-15.OXPHOS
ETS
SPermeabilized cells
Homogenate
Isolated mitochondria
RatLiver
Makrecka-Kuka 2015 Biomolecules2015
O2k-Protocols contents
Makrecka-Kuka M, Krumschnabel G, Gnaiger E (2015) High-resolution respirometry for simultaneous measurement of oxygen and hydrogen peroxide fluxes in permeabilized cells, tissue homogenate and isolated mitochondria. Biomolecules 5:1319-38.
LEAK
ROUTINE
OXPHOS
ETS
N
S
NS
ROX
Intact cells
Permeabilized cells
Homogenate
Isolated mitochondria
Human
Mouse
Heart
Nervous system
HEK
Pasdar 2015 PLoS One2015Pasdar EA, Smits M, Stapelberg M, Bajzikova M, Stantic M, Goodwin J, Yan B, Stursa J, Kovarova J, Sachaphibulkij K, Bezawork-Geleta A, Sobol M, Filimonenko A, Tomasetti M, Zobalova R, Hozak P, Dong LF, Neuzil J (2015) Characterisation of mesothelioma-initiating cells and their susceptibility to anti-cancer agents. PLoS One 10:e0119549.LEAK
ROUTINE
OXPHOS
ETS
N
S
NS
Intact cells
Permeabilized cells
Human
Mouse
Endothelial;epithelial;mesothelial cell
Other cell lines
Woodlief 2015 Obesity (Silver Spring)2015Woodlief TL, Carnero EA, Standley RA, Distefano G, Anthony SJ, Dubis GS, Jakicic JM, Houmard JA, Coen PM, Goodpaster BH (2015) Dose response of exercise training following roux-en-Y gastric bypass surgery: A randomized trial. Obesity (Silver Spring) 23:2454-61.LEAK
OXPHOS
ETS
N
NS
Permeabilized tissueHumanSkeletal muscle
Fouret 2015 Biochim Biophys Acta2015Fouret G, Tolika E, Lecomte J, Bonafos B, Aoun M, Murphy MP, Ferreri C, Chatgilialoglu C, Dubreucq E, Coudray C, Feillet-Coudray C (2015) The mitochondrial-targeted antioxidant, MitoQ, increases liver mitochondrial cardiolipin content in obesogenic diet-fed rats. Biochim Biophys Acta 1847:1025-35.OXPHOS
ETS
NSIsolated mitochondriaRatLiver
Petrus 2015 Can J Physiol Pharmacol2015Petruş A, Duicu OM, Sturza A, Noveanu L, Kiss L, Dănilă M, Baczkó I, Muntean DM, Jost N (2015) Modulation of mitochondrial respiratory function and ROS production by novel benzopyran analogues. Can J Physiol Pharmacol 93:811-8.LEAK
OXPHOS
ETS
N
ROX
Isolated mitochondriaRatHeart
Khiati 2015 Proc Natl Acad Sci U S A2015Khiati S, Baechler SA, Factor VM, Zhang H, Huang SY, Dalla Rosa I, Sourbier C, Neckers L, Thorgeirsson SS, Pommier Y (2015) Lack of mitochondrial topoisomerase I (TOP1mt) impairs liver regeneration. Proc Natl Acad Sci U S A 112:11282-7.LEAK
ROUTINE
ETS
Intact cellsHumanEndothelial;epithelial;mesothelial cell
Other cell lines
Schoettl 2015 Endocrinology2015Schöttl T, Kappler L, Braun K, Fromme T, Klingenspor M (2015) Limited mitochondrial capacity of visceral versus subcutaneous white adipocytes in male C57BL/6N mice. Endocrinology 156:923-33.LEAK
ROUTINE
OXPHOS
ETS
N
S
ROX
Intact cells
Permeabilized cells
Isolated mitochondria
MouseFat
Kawalec 2015 PLoS One2015Kawalec M, Boratyńska-Jasińska A, Beręsewicz M, Dymkowska D, Zabłocki K, Zabłocka B (2015) Mitofusin 2 deficiency affects energy metabolism and mitochondrial biogenesis in MEF cells. PLoS One 10:e0134162.ETS
LEAK
ROUTINE
Permeabilized cellsMouseFibroblast
Mourier 2015 J Cell Biol2015Mourier A, Motori E, Brandt T, Lagouge M, Atanassov I, Galinier A, Rappl G, Brodesser S, Hultenby K, Dieterich C, Larsson NG (2015) Mitofusin 2 is required to maintain mitochondrial coenzyme Q levels. J Cell Biol 208:429-42.LEAK
OXPHOS
ETS
N
S
Gp
Other combinations
Permeabilized cells
Isolated mitochondria
MouseHeart
Fibroblast
Lehtola 2015 Master's Thesis2015Lehtola A (2015) Main protein component of high density lipoprotein, apolipoprotein A1, modulates leukocyte cell respiration. Master's Thesis 1-44.LEAK
ROUTINE
OXPHOS
ETS
N
S
NS
ROX
Intact cells
Permeabilized cells
HumanBlood cells
Other cell lines
Lymphocyte
Jiroutkova 2015 Crit Care2015Jiroutková K, Krajčová A, Ziak J, Fric M, Waldauf P, Džupa V, Gojda J, Němcova-Fürstová V, Kovář J, Elkalaf M, Trnka J, Duška F (2015) Mitochondrial function in skeletal muscle of patients with protracted critical illness and ICU-acquired weakness. Crit Care 19:448.LEAK
OXPHOS
ETS
N
S
Gp
CIV
NS
Other combinations
ROX
HomogenateHumanSkeletal muscle
Soares 2015 PLoS One2015Soares JB, Gaviraghi A, Oliveira MF (2015) Mitochondrial physiology in the major arbovirus vector Aedes aegypti: substrate preferences and sexual differences define respiratory capacity and superoxide production. PLoS One 10:e0120600.LEAK
OXPHOS
ETS
N
S
Gp
NS
Other combinations
ROX
Permeabilized tissue
Isolated mitochondria
HexapodsSkeletal muscle
Cagnone 2015 Methods Mol Biol2015Cagnone G, Vaghjiani V, Lee W, Sun C, Johnson J, Yeung KY, St John JC (2015) Analysis of the mitochondrial DNA and its replicative capacity in induced pluripotent stem cells. Methods Mol Biol 1357:231-67.ETS
LEAK
ROUTINE
ROXIntact cellsHumanStem cells
Renner 2015 Eur J Immunol2015Renner K, Geiselhöringer AL, Fante M, Bruss C, Färber S, Schönhammer G, Peter K, Singer K, Andreesen R, Hoffmann P, Oefner P, Herr W, Kreutz M (2015) Metabolic plasticity of human T cells: Preserved cytokine production under glucose deprivation or mitochondrial restriction, but 2-deoxy-glucose affects effector functions. Eur J Immunol 45:2504-16.LEAK
ROUTINE
ETS
Intact cellsHumanBlood cells
Lymphocyte
Li 2015 Sci Rep2015Li P, Wang B, Sun F, Li Y, Li Q, Lang H, Zhao Z, Gao P, Zhao Y, Shang Q, Liu D, Zhu Z (2015) Mitochondrial respiratory dysfunctions of blood mononuclear cells link with cardiac disturbance in patients with early-stage heart failure. Sci Rep 5:10229.LEAK
ROUTINE
OXPHOS
ETS
N
S
NS
Intact cellsHumanBlood cells
Lymphocyte
Porter 2015 Med Sci Sports Exerc2015Porter C, Reidy PT, Bhattarai N, Sidossis LS, Rasmussen BB (2015) Resistance exercise training alters mitochondrial function in human skeletal muscle. Med Sci Sports Exerc 47:1922-31.ETS
LEAK
OXPHOS
N
NS
S
Permeabilized tissueHumanSkeletal muscle
Tyrrell 2015 Exp Gerontol2015Tyrrell DJ, Bharadwaj MS, Van Horn CG, Marsh AP, Nicklas BJ, Molina AJ (2015) Blood-cell bioenergetics are associated with physical function and inflammation in overweight/obese older adults. Exp Gerontol 70:84-91.LEAK
ETS
Intact cellsHumanBlood cells
Lymphocyte
Lee 2015 Methods Mol Biol2015Lee W, Kelly RD, Yeung KY, Cagnone G, McKenzie M, John JC (2015) Analysis of mitochondrial DNA in induced pluripotent and embryonic stem cells. Methods Mol Biol 1330:219-52.LEAK
ROUTINE
ETS
ROXIntact cellsMouseStem cells
Rodrigues 2015 J Cell Biochem2015Rodrigues MF, Carvalho É, Pezzuto P, Rumjanek FD, Amoêdo ND (2015) Reciprocal modulation of histone deacetylase inhibitors sodium butyrate and trichostatin a on the energy metabolism of breast cancer cells. Int J Biochem Cell Biol 116:797-808.LEAK
ROUTINE
OXPHOS
ETS
ROXIntact cellsHumanEndothelial;epithelial;mesothelial cell
Other cell lines
Hagl 2015 Molecules2015Hagl S, Berressem D, Bruns B, Sus N, Frank J, Eckert GP (2015) Beneficial Effects of Ethanolic and Hexanic Rice Bran Extract on Mitochondrial Function in PC12 Cells and the Search for Bioactive Components. Molecules 20(9):16524-39.LEAK
ROUTINE
OXPHOS
ETS
N
S
CIV
NS
ROX
Permeabilized cellsRatNervous system
Other cell lines
Tesori 2015 Sci Rep2015Tesori V, Piscaglia AC, Samengo D, Barba M, Bernardini C, Scatena R, Pontoglio A, Castellini L, Spelbrink JN, Maulucci G, Puglisi MA, Pani G, Gasbarrini A (2015) The multikinase inhibitor Sorafenib enhances glycolysis and synergizes with glycolysis blockade for cancer cell killing. Sci Rep 5:9149.LEAK
ROUTINE
ETS
Intact cellsRatLiver
Other cell lines
Stem cells
Hagl 2015 J Alzheimers Dis2015Hagl S, Grewal R, Ciobanu I, Helal A, Khayyal MT, Muller WE, Eckert GP (2015) Rice bran extract compensates mitochondrial dysfunction in a cellular model of early Alzheimer’s disease. J Alzheimers Dis 43:927-38.LEAK
OXPHOS
ETS
N
S
CIV
NS
ROX
Permeabilized cellsRatNervous system
Kidney
Other cell lines
Kruska 2015 Biochim Biophys Acta2015Kruska N, Schönfeld P, Pujol A, Reiser G (2015) Astrocytes and mitochondria from adrenoleukodystrophy protein (ABCD1)-deficient mice reveal that the adrenoleukodystrophy-associated very long-chain fatty acids target several cellular energy-dependent functions. Biochim Biophys Acta 1852:925-36.LEAK
OXPHOS
ETS
N
NS
Isolated mitochondriaMouseNervous system
Peyta 2015 Biochim Biophys Acta2015Peyta L, Jarnouen K, Pinault M, Coulouarn C, Guimaraes C, Goupille C, de Barros JP, Chevalier S, Dumas JF, Maillot F, Hatch GM, Loyer P, Servais S (2015) Regulation of hepatic cardiolipin metabolism by TNFα: Implication in cancer cachexia. Biochim Biophys Acta 1851:1490-500.LEAK
ROUTINE
OXPHOS
ETS
NSIntact cells
Permeabilized cells
RatLiver
Other cell lines
Chu 2015 Liver Transpl2015Chu MJ, Hickey AJ, Jiang Y, Petzer A, Bartlett AS, Phillips AR (2015) Mitochondrial dysfunction in steatotic rat livers occurs because a defect in complex I makes the liver susceptible to prolonged cold ischemia. Liver Transpl 21:396-407.LEAK
OXPHOS
ETS
N
S
HomogenateRatLiver
Kilbaugh 2015 Exp Neurol2015Kilbaugh TJ, Karlsson M, Byro M, Bebee A, Ralston J, Sullivan S, Duhaime AC, Hansson MJ, Elmér E, Margulies SS (2015) Mitochondrial bioenergetic alterations after focal traumatic brain injury in the immature brain. Exp Neurol 271:136-144.LEAK
ROUTINE
OXPHOS
ETS
N
S
CIV
NS
ROX
Permeabilized tissue
Homogenate
PigNervous system
Bernhardt 2015 Sci Rep2015Bernhardt D, Müller M, Reichert AS, Osiewacz HD (2015) Simultaneous impairment of mitochondrial fission and fusion reduces mitophagy and shortens replicative lifespan. Sci Rep 5:7885.ROUTINE
ETS
ROXIntact cellsSaccharomyces cerevisiae
Coupling control protocol2015Gnaiger E (2015) From PCP to CCP. Mitochondr Physiol Network 2015-01-11.LEAK
ROUTINE
OXPHOS
ETS
Cahill 2015 J Biol Chem2015Cahill TJ, Leo V, Kelly M, Stockenhuber A, Kennedy NW, Bao L, Cereghetti G, Harper AR, Czibik G, Lao C, Bellahcene M, Steeples V, Ghaffari S, Yavari A, Mayer A, Poulton J, Ferguson D, Scorrano L, Hettiarachchi NT, Peers C, Boyle J, Hill RB, Simmons A, Watkins H, Dear TN, Ashrafian H (2015) Resistance of dynamin-related protein 1 oligomers to disassembly impairs mitophagy resulting in myocardial inflammation and heart failure. J Biol Chem 290:25907-19.LEAK
OXPHOS
ETS
N
S
NS
ROX
Permeabilized tissueMouseHeart
Sundaram 2015 Mol Microbiol2015Sundaram V, Petkova MI, Pujol-Carrion N, Boada J, de la Torre-Ruiz MA (2015) Tor1, Sch9 and PKA downregulation in quiescence rely on Mtl1 to preserve mitochondrial integrity and cell survival. Mol Microbiol 97:93-109.LEAK
ROUTINE
ETS
ROXIntact cellsSaccharomyces cerevisiae
Keane 2015 Clin Sci (Lond)2015Keane KN, Calton EK, Cruzat VF, Soares MJ, Newsholme P (2015) The impact of cryopreservation on human peripheral blood leukocyte bioenergetics. Clin Sci (Lond) 128:723–33.ROUTINE
ETS
Intact cellsHumanBlood cells
Crombie 2015 Biochem Biophys Rep2015Crombie DE, van Bergena N, Davidsona KC, Anjomani Virmounib S, Mckelviec PA, Chrysostomoua V, Conquesta A, Corbend LA, Pookb MA, Kulkarnia T, Trouncea IA, Peraf MF, Delatyckid MB, Pébaya A (2015) Characterization of the retinal pigment epithelium in Friedreich ataxia. Biochem Biophys Rep 4:141–7.LEAK
OXPHOS
ETS
N
S
NS
ROX
Permeabilized cellsHumanNervous system
Endothelial;epithelial;mesothelial cell
Stem cells
Kluckova 2015 Cell Death Dis2015Kluckova K, Sticha M, Cerny J, Mracek T, Dong L, Drahota Z, Gottlieb E, Neuzil J, Rohlena J (2015) Ubiquinone-binding site mutagenesis reveals the role of mitochondrial complex II in cell death initiation. Cell Death Dis 6:e1749.OXPHOS
ETS
S
ROX
Permeabilized cells
Isolated mitochondria
Other mammalsLung;gill
Other cell lines
Fibroblast
Coen 2015 Diabetes2015Coen PM, Menshikova EV, Distefano G, Zheng D, Tanner CJ, Standley RA, Helbling NL, Dubis GS, Ritov VB, Xie H, Desimone ME, Smith SR, Stefanovic-Racic M, Toledo FG, Houmard JA, Goodpaster BH (2015) Exercise and weight loss improve muscle mitochondrial respiration, lipid partitioning, and insulin sensitivity after gastric bypass surgery. Diabetes 64:3737-50.ETS
LEAK
OXPHOS
F
N
NS
Other combinations
Permeabilized tissueHumanSkeletal muscle
Hezel 2015 Redox Biol2015Hezel MP, Liu M, Schiffer TA, Larsen FJ, Checa A, Wheelock CE, Carlström M, Lundberg JO, Weitzberg E (2015) Effects of long-term dietary nitrate supplementation in mice. Redox Biol 5:234-42.LEAK
OXPHOS
ETS
NIsolated mitochondriaMouseSkeletal muscle
Bratic 2015 Nat Commun2015Bratic A, Kauppila TE, Macao B, Grönke S, Siibak T, Stewart JB, Baggio F, Dols J, Partridge L, Falkenberg M, Wredenberg A, Larsson NG (2015) Complementation between polymerase- and exonuclease-deficient mitochondrial DNA polymerase mutants in genomically engineered flies. Nat Commun 6:8808.LEAK
OXPHOS
ETS
NPermeabilized tissueDrosophila
Hexapods
Torelli 2015 Free Radic Biol Med2015Torelli NQ, Ferreira-Júnior JR, Kowaltowski AJ, da Cunha FM (2015) RTG1- and RTG2-dependent retrograde signaling controls mitochondrial activity and stress resistance in Saccharomyces cerevisiae. Free Radic Biol Med 81C:30-7.LEAK
ROUTINE
OXPHOS
ETS
CIV
ROX
Intact cells
Isolated mitochondria
Saccharomyces cerevisiae
Hansen 2015 Shock2015Hansen ME, Simmons KJ, Tippetts TS, Thatcher MO, Saito RR, Hubbard ST, Trumbull AM, Parker BA, Taylor OJ, Bikman BT (2015) Lipopolysaccharide disrupts mitochondrial physiology in skeletal muscle via disparate effects on sphingolipid metabolism. Shock 44:585-92.OXPHOS
ETS
N
NS
ROX
Permeabilized cells
Permeabilized tissue
MouseSkeletal muscle
Jezek 2015 Antioxid Redox Signal2015Ježek J, Dlasková A, Zelenka J, Jabůrek M, Ježek P (2015) H2O2-Activated Mitochondrial Phospholipase iPLA2γ Prevents Lipotoxic Oxidative Stress in Synergy with UCP2, Amplifies Signaling via G-protein-coupled receptor GPR40, and regulates insulin secretion in pancreatic β-cells. Antioxid Redox Signal 23:958-72.ETSCIVPermeabilized cells
Isolated mitochondria
Islet cell;pancreas;thymus
Plecita-Hlavata 2015 J Bioenerg Biomembr2015Plecitá-Hlavatá L, Ježek J, Ježek P (2015) Aglycemia keeps mitochondrial oxidative phosphorylation under hypoxic conditions in HepG2 cells. J Bioenerg Biomembr 47(6):467-76.LEAK
ROUTINE
ETS
Intact cellsHumanLiver
Doerrier 2015 Thesis2015Doerrier C (2015) Estudio bioenergetica mitochondrial en la sepsis experimental y efecto protector de la Melatonina. Doctoral Thesis p154.LEAK
OXPHOS
ETS
N
S
NS
Permeabilized tissue
Isolated mitochondria
MouseHeart
Liver
Konopka 2015 Diabetes2015Konopka AR, Asante A, Lanza IR, Robinson MM, Johnson ML, Dalla Man C, Cobelli C, Amols MH, Irving BA, Nair KS (2015) Defects in mitochondrial efficiency and H2O2 emissions in obese women are restored to a lean phenotype with aerobic exercise training. Diabetes 64:2104-15.LEAK
OXPHOS
ETS
N
S
NS
ROX
Isolated mitochondriaHumanSkeletal muscle
Van Hoose 2015 Thesis2015Van Hoose P (2015) Co-treatment with conjugated linoleic acid and nitrite modulates mitochondrial respiration and electron transport chain activity in vivo and attenuates mitochondrial dysfunction during cardiac injury. Dissertations p128.LEAK
OXPHOS
ETS
Isolated mitochondriaMouseHeart
Hanssen 2015 Nat Med2015Hanssen MJ, Hoeks J, Brans B, van der Lans AA, Schaart G, van den Driessche JJ, Jörgensen JA, Boekschoten MV, Hesselink MK, Havekes B, Kersten S, Mottaghy FM, van Marken Lichtenbelt WD, Schrauwen P (2015) Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus. Nat Med 21:863-5.LEAK
OXPHOS
ETS
F
N
NS
Other combinations
Permeabilized tissueHumanSkeletal muscle
Rodrigues 2016 Biochem J2015Rodrigues MF, Obre E, Melo FH, Santos-Jr GC, Galina A, Jasiulionis MG, Rossignol R, Rumjanek FD, Amoedo ND (2016) Enhanced OXPHOS, glutaminolysis and beta-oxidation constitute the metastatic phenotype of melanoma cells. Biochem J 473:703-15.LEAK
ROUTINE
OXPHOS
ETS
F
N
S
ROX
Intact cells
Permeabilized cells
MouseEndothelial;epithelial;mesothelial cell
Other cell lines
Ping 2015 Oxid Med Cell Longev2015Ping Z, Zhang LF, Cui YJ, Chang YM, Jiang CW, Meng ZZ, Xu P, Liu HY, Wang DY, Cao XB (2015) The protective effects of Salidroside from exhaustive exercise-induced heart injury by enhancing the PGC-1𝛼–NRF1/NRF2 pathway and mitochondrial respiratory function in rats. Oxid Med Cell Longev Article ID 876825.OXPHOS
ETS
N
S
CIV
ROX
Permeabilized tissueRatHeart
Hagl 2015 Neurochem Int2015Hagl S, Kocher A, Schiborr C, Kolesova N, Frank J, Eckert GP (2015) Curcumin micelles improve mitochondrial function in neuronal PC12 cells and brains of NMRI mice - Impact on bioavailability. Neurochem Int 89:234-42.ETS
LEAK
OXPHOS
CIV
N
S
Isolated mitochondriaMouseNervous system
Hejzlarova 2015 Biochem J2015Hejzlarová K, Kaplanová V, Nůsková H, Kovářová N, Ješina P, Drahota Z, Mráček T, Seneca S, Houštěk J (2015) Alteration of structure and function of ATP synthase and cytochrome c oxidase by lack of Fo-a and Cox3 subunits caused by mitochondrial DNA 9205delTA mutation. Biochem J 466:601-11.LEAK
OXPHOS
ETS
S
CIV
Permeabilized cells
Isolated mitochondria
HumanOther cell lines
Boss 2015 US Patent2015Boss OD, Crisan M, Giacobino JP, (2015) Brown adipocyte progenitors in human sceletal muscle. US Patent US 2015/0240206 A1.LEAK
ROUTINE
ETS
ROXPermeabilized cellsHuman
Mouse
Skeletal muscle
Endothelial;epithelial;mesothelial cell
Fat
Hansson 2015 Eur J Pharmacol2015Hansson MJ, Llwyd O, Morin D, de Paulis D, Arnoux T, Gouarné C, Koul S, Engblom H, Bordet T, Tissier R, Arheden H, Erlinge D, Halestrap AP, Berdeaux A, Pruss RM, Schaller S (2015) Differences in the profile of protection afforded by TRO40303 and mild hypothermia in models of cardiac ischemia/reperfusion injury. Eur J Pharmacol 760:7-19.LEAK
OXPHOS
ETS
N
S
NS
Permeabilized tissuePigHeart
Plecita-Hlavata 2015 Am J Respir Cell Mol Biol2015Plecitá-Hlavatá L, Tauber J, Li M, Zhang H, Flockton AR, Pullamsetti SS, Chelladurai P, D'alessandro A, El Kasmi KC, Ježek P, Stenmark KR (2015) Constitutive reprogramming of fibroblast mitochondrial metabolism in pulmonary hypertension. Am J Respir Cell Mol Biol 55:47-57.LEAK
ROUTINE
OXPHOS
ETS
N
CIV
Other combinations
Intact cells
Isolated mitochondria
Human
Bovines
Endothelial;epithelial;mesothelial cell
Fibroblast
Khera 2015 Placenta2015Khera A, Dong LF, Holland O, Vanderlelie J, Pasdar EA, Neuzil J, Perkins AV (2015) Selenium supplementation induces mitochondrial biogenesis in trophoblasts. Placenta 36:863-9.LEAK
ROUTINE
OXPHOS
ETS
N
S
CIV
Intact cells
Permeabilized cells
HumanGenital
Other cell lines
Ikaga 2015 Biochem Biophys Rep2015Ikaga R, Namekatac I, Kotiadisd VN, Ogawab H, Duchend MR, Tanakac H, Iida-Tanakab N (2015) Knockdown of aquaporin-8 induces mitochondrial dysfunction in 3T3-L1 cells. Biochem Biophys Rep 4:187–95.ETS
LEAK
ROUTINE
CIV
ROX
Intact cellsMouseFat
Other cell lines
Kasvandik 2015 J Proteome Res2015Kasvandik S, Samuel K, Peters M, Eimre M, Peet N, Roost AM, Padrik L, Paju K, Peil L, Salumets A (2015) Deep quantitative proteomics reveals extensive metabolic reprogramming and cancer-like changes of ectopic endometriotic stromal cells. J Proteome Res 15:572-84.LEAK
ROUTINE
ETS
ROXHumanGenital
Other cell lines
Birkenmeier 2015 Int J Cancer2015Birkenmeier K, Dröse S, Wittig I, Winkelmann R, Käfer V, Döring C, Hartmann S, Wenz T, Reichert AS, Brandt U, Hansmann ML (2015) Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma are highly dependent on oxidative phosphorylation. Int J Cancer 138:2231-46.LEAK
ROUTINE
ETS
CIV
ROX
HumanOther cell lines
HeLa
Macrophage-derived
Assmann 2014 PhD Thesis2015Assman N (2015) Impact of Fanconi-associated protein on the mitochonrial proteome. PhD Thesis 1-111.LEAK
ROUTINE
OXPHOS
ETS
F
N
S
CIV
NS
ROX
Intact cells
Permeabilized cells
PigKidney
Other cell lines
Nelson 2015 Master Thesis2015Nelson MB (2015) The role of receptors for advanced glycation end-products (RAGE) and ceramide in cardiovascular disease. Master Thesis 1-53.LEAK
OXPHOS
ETS
N
S
NS
Permeabilized cells
Permeabilized tissue
Mouse
Rat
Heart
Other cell lines
Yan 2015 BMC Cancer2015Yan B, Stantic M, Zobalova R, Bezawork-Geleta A, Stapelberg M, Stursa J, Prokopova K, Dong L, Neuzil J (2015) Mitochondrially targeted vitamin E succinate efficiently kills breast tumour-initiating cells in a complex II-dependent manner. BMC Cancer 15:401.ETS
LEAK
OXPHOS
ROUTINE
N
NS
ROX
S
Intact cells
Permeabilized cells
Human
Mouse
Genital
Other cell lines
Lisak 2015 Cell Death Differ2015Lisak D, Schacht T, Gawlitza A, Albrecht P, Aktas O, Koop B, Gliem M, Hofstetter HH, Zanger K, Bultynck G, Parys JB, De Smedt H, Kindler T, Adams-Quack P, Hahn M, Waisman A, Reed JC, Hövelmeyer N, Methner A (2015) BAX inhibitor-1 is a Ca2+ channel critically important for immune cell function and survival. Cell Death Differ 23:358-68.LEAK
ROUTINE
ETS
ROXIntact cellsMouseBlood cells
Lymphocyte
Baris 2015 Am J Physiol Regul Integr Comp Physiol2015Baris TZ, Crawford DL, Oleksiak MF (2015) Acclimation and acute temperature effects on population differences in oxidative phosphorylation. Am J Physiol Regul Integr Comp Physiol 310:R185-96.LEAK
OXPHOS
ETS
N
S
CIV
NS
Other combinations
ROX
Permeabilized tissueFishesHeart
Sheldon 2015 Am J Physiol Gastrointest Liver Physiol2015Sheldon RD, Padilla J, Jenkins NT, Laughlin MH, Rector RS (2015) Chronic NOS inhibition accelerates NAFLD progression in an obese rat model. Am J Physiol Gastrointest Liver Physiol 308:G540-9.LEAK
OXPHOS
ETS
N
NS
Isolated mitochondriaRatLiver
Wessels 2015 Am J Physiol2015Wessels B, van den Broek NM, Ciapaite J, Houten SM, Wanders RJ, Nicolay K, Prompers JJ. (2015) Carnitine supplementation in high-fat diet-fed rats does not ameliorate lipid-induced skeletal muscle mitochondrial dysfunction in vivo. Am J Physiol 309(7):E670-8.LEAK
OXPHOS
ETS
F
N
Isolated mitochondriaRatSkeletal muscle
Koliaki 2015 Cell Metab2015Koliaki C, Szendroedi J, Kaul K, Jelenik T, Nowotny P, Jankowiak F, Herder C, Carstensen M, Krausch M, Knoefel WT, Schlensak M, Roden M (2015) Adaptation of hepatic mitochondrial function in humans with non-alcoholic fatty liver is lost in steatohepatitis. Cell Metab 21:739-46.LEAK
OXPHOS
ETS
F
N
NS
Other combinations
ROX
Homogenate
Isolated mitochondria
HumanLiver
Weidinger 2015 Antioxid Redox Signal2015Weidinger A, Müllebner A, Paier-Pourani J, Banerjee A*, Miller I, Lauterböck L, Duvigneau JC, Skulachev VP, Redl H, Kozlov AV (2015) Vicious inducible nitric oxide synthase-mitochondrial reactive oxygen species cycle accelerates inflammatory response and causes liver injury in rats. Antioxid Redox Signal 22:572-86.LEAK
OXPHOS
ETS
N
S
HomogenateRatLiver
Dungel 2015 Free Radic Biol Med2015Dungel P, Perlinger M, Weidinger A, Redl H, Kozlov AV (2015) The cytoprotective effect of nitrite is based on the formation of dinitrosyl iron complexes. Free Radic Biol Med 89:300-10.ETS
LEAK
OXPHOS
N
S
Isolated mitochondriaRatLiver
Zelenka 2015 Oxid Med Cell Longev2015Zelenka J, Dvořák A, Alán L (2015) L-lactate protects skin fibroblasts against aging-associated mitochondrial dysfunction via mitohormesis. Oxid Med Cell Longev 2015:351698.LEAK
ROUTINE
ETS
N
S
Intact cells
Isolated mitochondria
RatLiver
Endothelial;epithelial;mesothelial cell
Fibroblast
Ziak 2015 Mitochondrion2015Ziak J, Krajcova A, Jiroutkova K, Nemcova V, Dzupa V, Duska F (2015) Assessing the function of mitochondria in cytosolic context in human skeletal muscle: Adopting high-resolution respirometry to homogenate of needle biopsy tissue samples. Mitochondrion 21:106-12.LEAK
OXPHOS
ETS
N
S
NS
ROX
Homogenate
Isolated mitochondria
HumanSkeletal muscle
Ortiz 2015 J Pineal Res2015Ortiz F, Acuña-Castroviejo D, Doerrier C, Dayoub JC, López LC, Venegas C, García JA, López A, Volt H, Luna-Sánchez M, Escames G (2015) Melatonin blunts the mitochondrial/NLRP3 connection and protects against radiation-induced oral mucositis. J Pineal Res 58:34-49.LEAK
OXPHOS
ETS
N
S
Homogenate
Isolated mitochondria
Lages 2015 PeerJ2015Lages YM, Nascimento JM, Lemos GA, Galina A, Castilho LR, Rehen SK (2015) Low oxygen alters mitochondrial function and response to oxidative stress in human neural progenitor cells. PeerJ 3:e1486.ETS
LEAK
ROUTINE
ROXIntact cellsHumanStem cells
Vincent 2015 Front Physiol2015Vincent G, Lamon S, Gant N, Vincent PJ, MacDonald JR, Markworth JF, Edge JA, Hickey AJ (2015) Changes in mitochondrial function and mitochondria associated protein expression in response to 2-weeks of high intensity interval training. Front Physiol 6:51.LEAK
OXPHOS
ETS
N
S
ROX
Permeabilized tissueHumanSkeletal muscle
Montero 2015 J Physiol2015Montero D, Cathomen A, Jacobs RA, Flück D, de Leur J, Keiser S, Bonne T, Kirk N, Lundby AK, Lundby C (2015) Haematological rather than skeletal muscle adaptations contribute to the increase in peak oxygen uptake induced by moderate endurance training. J Physiol 593:4677-88.OXPHOS
ETS
Permeabilized tissueHumanSkeletal muscle
Hanssen 2015 Diabetes2015Hanssen MJ, van der Lans AA, Brans B, Hoeks J, Jardon KM, Schaart G, Mottaghy FM, Schrauwen P, van Marken Lichtenbelt WD (2015) Short-term cold acclimation recruits brown adipose tissue in obese humans. Diabetes 65:1179-89.LEAK
OXPHOS
ETS
F
N
NS
Other combinations
Permeabilized tissueHumanSkeletal muscle
Flatters 2015 Prog Mol Biol Transl Sci2015Flatters SJ (2015) The contribution of mitochondria to sensory processing and pain. Prog Mol Biol Transl Sci 131:119-46.OXPHOS
ETS
N
S
CIV
NS
Homogenate
Isolated mitochondria
RatNervous system
Hals 2015 PLoS One2015Hals IK, Bruerberg SG, Ma Z, Scholz H, Björklund A, Grill V (2015) Mitochondrial respiration in insulin-producing β-cells: general characteristics and adaptive effects of hypoxia. PLoS One 10:e0138558.LEAK
ROUTINE
OXPHOS
ETS
N
S
NS
ROX
Intact cells
Permeabilized cells
RatIslet cell;pancreas;thymus
Other cell lines
Jeger 2015 BioMed Res Internat2015Jeger V, Brandt S, Porta F, Jakob SM, Takala J, Djafarzadeh S (2015) Dose response of Endotoxin on hepatocyte and muscle mitochondrial respiration in vitro. BioMed Res Internat Article ID 353074:1-13.LEAK
ROUTINE
OXPHOS
ETS
N
S
CIV
NS
ROX
Intact cells
Permeabilized cells
Isolated mitochondria
HumanSkeletal muscle
Liver
Other cell lines
Ehinger 2015 J Neurol2015Ehinger JK, Morota S, Hansson MJ, Paul G, Elmér E (2015) Mitochondrial dysfunction in blood cells from amyotrophic lateral sclerosis patients. J Neurol 262:1493-503.LEAK
ROUTINE
OXPHOS
ETS
N
S
CIV
NS
ROX
Intact cells
Permeabilized cells
HumanBlood cells
Lymphocyte
Platelet
Zhunussova 2015 Am J Cancer Res2015Zhunussova A, Sen B, Friedman L, Tuleukhanov S, Brooks AD, Sensenig R, Orynbayeva Z (2015) Tumor microenvironment promotes dicarboxylic acid carrier-mediated transport of succinate to fuel prostate cancer mitochondria. Am J Cancer Res 5:1665-79.ETS
ROUTINE
SIntact cells
Permeabilized cells
Human
Rat
Endothelial;epithelial;mesothelial cell
Genital
Other cell lines
Porter 2015 Burns2015Porter C, Herndon DN, Bhattarai N, Ogunbileje JO, Szczesny B, Szabo C, Toliver-Kinsky T, Sidossis LS (2015) Differential acute and chronic effects of burn trauma on murine skeletal muscle bioenergetics. Burns 42:112-22.LEAK
OXPHOS
ETS
NS
Other combinations
Permeabilized tissueMouseSkeletal muscle
Kluckova 2015 Methods Mol Biol2015Kluckova K, Dong L, Bajzikova M, Rohlena J, Neuzil J (2015) Evaluation of respiration of mitochondria in cancer cells exposed to mitochondria-targeted agents. Methods Mol Biol 1265:181-94.ETS
LEAK
OXPHOS
N
NS
ROX
S
Homogenate
Intact cells
Permeabilized cells
MouseEndothelial;epithelial;mesothelial cell
Genital
Other cell lines
Errea 2015 J Neuroinflammation2015Errea O, Moreno B, Gonzalez-Franquesa A, Garcia-Roves PM, Villoslada P (2015) The disruption of mitochondrial axonal transport is an early event in neuroinflammation. J Neuroinflammation 12:152.LEAK
OXPHOS
ETS
N
S
CIV
NS
ROX
HomogenateMouseNervous system
Du 2015 J Biol Chem2015Du J, Rountree A, Cleghorn WM, Contreras L, Lindsay KJ, Sadilek M, Gu H, Djukovic D, Raftery D, Satrustegui J, Kanow M, Chan L, Tsang SH, Sweet IR, Hurley JB (2015) Phototransduction influences metabolic flux and nucleotide metabolism in mouse retina. J Biol Chem 291:4698-710.LEAK
ROUTINE
OXPHOS
ETS
N
ROX
Isolated mitochondriaMouseNervous system
Islet cell;pancreas;thymus
Christiansen 2015 J Vet Med Sci2015Christiansen LB, Dela F, Koch J, Yokota T (2015) Tissue-specific and substrate-specific mitochondrial bioenergetics in feline cardiac and skeletal muscles. J Vet Med Sci 77:669-75.LEAK
OXPHOS
ETS
F
N
S
CIV
NS
Other combinations
ROX
Permeabilized tissueCatHeart
Skeletal muscle
Clemens 2015 Brain2015Clemens LE, Weber JJ, Wlodkowski TT, Yu-Taeger L, Michaud M, Calaminus C, Eckert SH, Gaca J, Weiss A, Magg JC, Jansson EK, Eckert GP, Pichler BJ, Bordet T, Pruss RM, Riess O, Nguyen HP (2015) Olesoxime suppresses calpain activation and mutant huntingtin fragmentation in the BACHD rat. Brain 138:3632-53.LEAK
OXPHOS
ETS
N
S
CIV
NS
ROX
Isolated mitochondriaRatNervous system
Llobet 2015 Dis Model Mech2015Llobet L, Toivonen JM, Montoya J, Ruiz-Pesini E, López-Gallardo E (2015) OXPHOS xenobiotics alter adipogenic differentiation at concentrations found in human blood. Dis Model Mech 8:1441-55.LEAK
ROUTINE
ETS
Intact cellsHumanFat
Stem cells
Drechsler 2015 Intensive Care Medicine Experimental2015Drechsler S, Weixelbaumer KM, Weidinger A, Raeven P, Khadem A, Redl H, van Griensven M, Bahrami S, Remick D, Kozlov A, Osuchowski MF (2015) Why do they die? Comparison of selected aspects of organ injury and dysfunction in mice surviving and dying in acute abdominal sepsis. Intensive Care Medicine Experimental 3:12.LEAK
OXPHOS
ETS
N
S
HomogenateMouseLiver
Kidney
Lourenco 2015 Front Aging Neurosci2015Lourenço CF, Ledo A, Dias C, Barbosa RM, Laranjinha J (2015) Neurovascular and neurometabolic derailment in aging and Alzheimer's disease. Front Aging Neurosci 7:103.ROUTINE
ETS
ROXIntact cellsMouseNervous system
Miwa 2015 Free Radic Biol Med2015Miwa S, Treumann A, Bell A, Vistoli G, Nelson G, Hay S, von Zglinicki T (2015) Carboxylesterase converts Amplex red to resorufin: Implications for mitochondrial H2O2 release assays.. Free Radic Biol Med 90:173-83.LEAK
OXPHOS
ETS
N
S
ROX
Isolated mitochondriaMouseLiver
Maiti 2015 PhD Thesis2015Maiti P (2015) The role of caseinolytic mitochondrial matrix peptidase proteolytic subunit (CLPP) in regulation of mitochondrial ribosome biogenesis in mammals. PhD Thesis 1-120.LEAK
OXPHOS
ETS
N
S
NS
ROX
Isolated mitochondriaMouseHeart
Houben 2015 Mitochondrion2015Houben R, Leleu C, Fraipont A, Serteyn D, Votion DM (2015) Determination of muscle mitochondrial respiratory capacity in Standardbred racehorses as an aid to predicting exertional rhabdomyolysis. Mitochondrion 24:99-104.OXPHOS
ETS
N
S
NS
ROX
Permeabilized tissueHorseSkeletal muscle
Porter 2015 Am J Physiol Endocrinol Metab2015Porter C, Hurren NM, Cotter MV, Bhattarai N, Reidy PT, Dillon EL, Durham WJ, Tuvdendorj D, Sheffield-Moore M, Volpi E, Sidossis LS, Rasmussen BB, Børsheim E (2015) Mitochondrial respiratory capacity and coupling control decline with age in human skeletal muscle. Am J Physiol Endocrinol Metab 309:E224-32.LEAK
OXPHOS
ETS
F
N
NS
Other combinations
Permeabilized tissueHumanSkeletal muscle
Iftikar 2015 Comp Biochem Physiol A Mol Integr Physiol2015Iftikar FI, Morash AJ, Cook DG, Herbert NA, Hickey AJ (2015) Temperature acclimation of mitochondria function from the hearts of a temperate wrasse (Notolabrus celidotus). Comp Biochem Physiol A Mol Integr Physiol 184:46-55.ETS
LEAK
OXPHOS
CIV
N
NS
ROX
S
Permeabilized tissueFishesHeart
Canto 2015 Curr Protoc Mouse Biol2015Cantó C, Garcia-Roves PM (2015) High-resolution respirometry for mitochondrial characterization of ex vivo mouse tissues. Curr Protoc Mouse Biol 5:135-53.LEAK
OXPHOS
ETS
N
S
NS
Permeabilized tissue
Homogenate
MouseHeart
Skeletal muscle
Nervous system
Liver
Fat
Seillier 2015 EMBO Mol Med2015Seillier M, Pouyet L, N'Guessan P, Nollet M, Capo F, Guillaumond F, Peyta L, Dumas JF, Varrault A, Bertrand G, Bonnafous S, Tran A, Meur G, Marchetti P, Ravier MA, Dalle S, Gual P, Muller D, Rutter GA, Servais S, Iovanna JL, Carrier A (2015) Defects in mitophagy promote redox-driven metabolic syndrome in the absence of TP53INP1. EMBO Mol Med 7:802-18.LEAK
ROUTINE
OXPHOS
ETS
F
CIV
NS
ROX
Intact cells
Permeabilized cells
Human
Mouse
Fibroblast
Smolkova 2015 Int J Biochem Cell Biol2015Smolková K, Dvořák A, Zelenka J, Vítek L, Ježek P (2015) Reductive carboxylation and 2-hydroxyglutarate formation by wild-type IDH2 in breast carcinoma cells. Int J Biochem Cell Biol 65:125-33.LEAK
ROUTINE
ETS
ROXIntact cellsHumanEndothelial;epithelial;mesothelial cell
Other cell lines
Schirris 2015 Cell Metab2015Schirris TJ, Renkema GH, Ritschel T, Voermans NC, Bilos A, van Engelen BG, Brandt U, Koopman WJ, Beyrath JD, Rodenburg RJ, Willems PH, Smeitink JA, Russel FG (2015) Statin-induced myopathy is associated with mitochondrial complex III inhibition. Cell Metab 22:399-407.ROUTINE
OXPHOS
ETS
N
S
Gp
CIV
NS
ROX
Permeabilized cellsHuman
Mouse
Skeletal muscle
Other cell lines
Senyilmaz 2015 Nature2015Senyilmaz D, Virtue S, Xu X, Tan CY, Griffin JL, Miller AK, Vidal-Puig A, Teleman AA (2015) Regulation of mitochondrial morphology and function by stearoylation of TFR1. Nature 525:124-8.OXPHOS
ETS
N
S
CIV
NS
Permeabilized tissueDrosophila
Madsen 2015 Nat Commun2015Madsen CT, Sylvestersen KB, Young C, Larsen SC, Poulsen JW, Andersen MA, Palmqvist EA, Hey-Mogensen M, Jensen PB, Treebak JT, Lisby M, Nielsen ML (2015) Biotin starvation causes mitochondrial protein hyperacetylation and partial rescue by the SIRT3-like deacetylase Hst4p. Nat Commun 6:7726.ROUTINE
ETS
Intact cellsSaccharomyces cerevisiae
Bowen 2015 Eur J Heart Fail2015Bowen TS, Rolim NP, Fischer T, Baekkerud FH, Medeiros A, Werner S, Brønstad E, Rognmo O, Mangner N, Linke A, Schuler G, Silva GJ, Wisløff U, Adams V (2015) Heart failure with preserved ejection fraction induces molecular, mitochondrial, histological, and functional alterations in rat respiratory and limb skeletal muscle. Eur J Heart Fail 17:263-72.LEAK
OXPHOS
ETS
N
NS
Permeabilized tissueRatSkeletal muscle
Kilbaugh 2015 J Am Heart Assoc2015Kilbaugh TJ, Sutton RM, Karlsson M, Hansson MJ, Naim MY, Morgan RW, Bratinov G, Lampe JW, Nadkarni VM, Becker LB, Margulies SS, Berg RA (2015) Persistently Altered Brain Mitochondrial Bioenergetics After Apparently Successful Resuscitation From Cardiac Arrest. J Am Heart Assoc 4(9) pii: e002232.LEAK
OXPHOS
ETS
N
S
CIV
NS
ROX
HomogenatePigNervous system
Wessels 2015 Diabetes Obes Metab2015Wessels B, Ciapaite J, van den Broek NM, Houten SM, Nicolay K, Prompers JJ (2015) Pioglitazone treatment restores in vivo muscle oxidative capacity in a rat model of diabetes. Diabetes Obes Metab 17:52-60.LEAK
OXPHOS
ETS
F
N
S
Isolated mitochondriaRatSkeletal muscle
Van Rahden 2015 Am J Hum Genet2015van Rahden VA, Fernandez-Vizarra E, Alawi M, Brand K, Fellmann F, Horn D, Zeviani M, Kutsche K (2015) Mutations in NDUFB11, encoding a complex I component of the mitochondrial respiratory chain, cause microphthalmia with linear skin defects syndrome. Am J Hum Genet 96:640-50.LEAK
ROUTINE
ETS
Intact cellsHumanHeLa
Antoun 2015 JIMD Rep2015Antoun G, McBride S, Vanstone JR, Naas T, Michaud J, Redpath S, McMillan HJ, Brophy J, Daoud H, Chakraborty P, Dyment D, Holcik M, Harper ME, Lines MA (2015) Detailed biochemical and bioenergetic characterization of FBXL4-related encephalomyopathic mitochondrial DNA depletion. JIMD Rep 27:1-9.LEAK
OXPHOS
ETS
F
N
S
CIV
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Kruse 2015 Aging Cell2015Kruse SE, Karunadharma PP, Basisty N, Johnson R, Beyer RP, MacCoss MJ, Rabinovitch PS, Marcinek DJ (2015) Age modifies respiratory complex I and protein homeostasis in a muscle type-specific manner. Aging Cell 15:89-99.LEAK
OXPHOS
ETS
N
S
CIV
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Hanssen 2015 Diabetologia2015Hanssen MJ, Wierts R, Hoeks J, Gemmink A, Brans B, Mottaghy FM, Schrauwen P, van Marken Lichtenbelt WD (2015) Glucose uptake in human brown adipose tissue is impaired upon fasting-induced insulin resistance. Diabetologia 58:586-95.LEAK
ETS
FIsolated mitochondriaHumanSkeletal muscle
Dueregger 2015 PLoS One2015Dueregger A, Schöpf B, Eder T, Höfer J, Gnaiger E, Aufinger A, Kenner L, Perktold B, Ramoner R, Klocker H, Eder IE (2015) Differential utilization of dietary fatty acids in benign and malignant cells of the prostate. PLoS One 10(8):e0135704.LEAK
ROUTINE
OXPHOS
ETS
F
N
NS
ROX
Permeabilized cells
Permeabilized tissue
HumanGenital
Other cell lines
Hasli 2015 Master Thesis2015Hasli PR (2015) Characterization of mitochondrial respiration and quality differences in diploid and triploid Atlantic salmon (Salmo salar L.) at 5 °C, 10 °C and 15 °C. Master Thesis:1-147.LEAK
OXPHOS
ETS
N
S
NS
ROX
Permeabilized tissue
Homogenate
FishesHeart
Skeletal muscle
Hecker 2015 Methods Mol Biol2015Hecker M, Sommer N, Mayer K (2015) Assessment of short- and medium-chain fatty acids on mitochondrial function in severe Inflammation. Methods Mol Biol 1265:389-96.LEAK
ROUTINE
ETS
ROXIntact cellsHumanEndothelial;epithelial;mesothelial cell
ETS coupling efficiency2015Gnaiger E (2015) Biochemical coupling efficiency: from 0 to <1. Mitochondr Physiol Network 2015-01-18.LEAK
ETS
Garama 2015 Mol Cell Biol2015Garama DJ, Harris TJ, White CL, Rossello FJ, Abdul-Hay M, Gough DJ, Levy DE (2015) A Synthetic Lethal Interaction between Glutathione Synthesis and Mitochondrial Reactive Oxygen Species Provides a Tumor-Specific Vulnerability Dependent on STAT3. Mol Cell Biol 35(21):3646-56.LEAK
ROUTINE
ETS
Intact cellsMouseEndothelial;epithelial;mesothelial cell
Fibroblast
Warne 2015 J Biol Chem2015Warne J, Pryce G, Hill J, Shi X, Lennerås F, Puentes F, Kip M, Hilditch L, Walker P, Simone MI, Chan AW, Towers GJ, Coker A, Duchen MR, Szabadkai G, Baker D, Selwood D (2015) Selective inhibition of the mitochondrial permeability transition pore protects against neuro-degeneration in experimental multiple sclerosis. J Biol Chem 291:4356-73.LEAK
OXPHOS
ETS
N
ROX
Isolated mitochondriaMouseLiver
Krumschnabel 2015 Methods Mol Biol2015
O2k-Protocols contents
Krumschnabel G, Fontana-Ayoub M, Sumbalova Z, Heidler J, Gauper K, Fasching M, Gnaiger E (2015) Simultaneous high-resolution measurement of mitochondrial respiration and hydrogen peroxide production. Methods Mol Biol 1264:245-61.
LEAK
OXPHOS
ETS
N
S
NS
ROX
Isolated mitochondriaMouseNervous system
Banerjee 2015 Placenta2015Banerjee A, Weidinger A, Hofer M, Steinborn R, Lindenmair A, Hennerbichler-Lugscheider S, Eibl J, Redl H, Kozlov AV, Wolbank S (2015) Different metabolic activity in placental and reflected regions of the human amniotic membrane. Placenta 36:1329-32.ROUTINE
OXPHOS
ETS
NIntact cells
Permeabilized tissue
HumanGenital
Bonsignore 2015 Mech Ageing Dev2015Bonsignore LA, Tooley JG, Van Hoose PM, Wang E, Cheng A, Cole MP, Schaner Tooley CE (2015) NRMT1 knockout mice exhibit phenotypes associated with impaired DNA repair and premature aging. Mech Ageing Dev 146-148:42-52.LEAK
OXPHOS
ETS
N
ROX
Isolated mitochondriaMouseLiver
Labieniec-Watala 2015 Int J Pharm Sci Res2015Labieniec-Watala M, Przygodzki T, Siewiera K, Podsedek A, Watala C (2015) Facts and artifacts in the evaluation of the anti-diabetic activity of spent hop extract in rat hearts in the “experimental model of diabetes. Int J Pharm Sci Res 1:106.LEAK
OXPHOS
ETS
S
ROX
Isolated mitochondriaRatHeart
MiPNet12.01 Suppl T-issue2014-07-20
O2k-Protocols contents
MitoPathways at the Q-junction: mouse skeletal muscle fibres.
LEAK
ROUTINE
ETS
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
MiPNet12.11 MitoRespiration2014-02-20
O2k-Protocols
Flux control ratios in isolated mitochondria. OXPHOS capacity and respiratory control.
LEAK
OXPHOS
ETS
SIsolated mitochondriaArtemia
Crustaceans
Dube 2014 Am J Physiol Endocrinol Metab2014Dube JJ, Coen PM, DiStefano G, Chacon AC, Helbling NL, Desimone ME, Stafanovic-Racic M, Hames KC, Despines AA, Toledo FG, Goodpaster BH (2014) Effects of acute lipid overload on skeletal muscle insulin resistance, metabolic flexibility, and mitochondrial performance. Am J Physiol Endocrinol Metab 307:E1117-24.LEAK
OXPHOS
ETS
Permeabilized tissueHumanSkeletal muscle
Kramer 2014 J Vis Exp2014Kramer PA, Chacko BK, Ravi S, Johnson MS, Mitchell T, Darley-Usmar VM (2014) Bioenergetics and the oxidative burst: protocols for the isolation and evaluation of human leukocytes and platelets. J Vis Exp 2014 Mar 27(85). doi: 10.3791/51301.LEAK
ROUTINE
ETS
Intact cellsHumanBlood cells
Platelet
Pham 2014 Am J Physiol2014Pham T, Loiselle D, Power A, Hickey AJ (2014) Mitochondrial inefficiencies and anoxic ATP hydrolysis capacities in diabetic rat heart. Am J Physiol 307:C499–507.LEAK
OXPHOS
ETS
N
NS
ROX
HomogenateRatHeart
Hereng 2014 Human Reprod2014Hereng TH, Elgstoen KBP, Eide L, Rosendal KR, Skalhegg BS (2014) Serum albumin and HCO3 2 regulate separate pools of ATP in human spermatozoa. Human Reprod 29:918-30.ETS
LEAK
ROUTINE
Intact cellsHumanGenital
Widmann 2014 Thesis2014Widmann M (2014) Effekte von Noradrenalin und LPS auf die mitochondriale Atmung von Alveolarmakrophagen. Thesis Universität Ulm, Medizinische Fakultät. 63 pp.LEAK
ROUTINE
ETS
ROXIntact cellsMouseLung;gill
Other cell lines
Hort 2014 Biochimie2014Hort MA, Straliotto MR, de Oliveira J, Amoêdo ND, da Rocha JB, Galina A, Ribeiro-do-Valle RM, de Bem AF (2014) Diphenyl diselenide protects endothelial cells against oxidized low density lipoprotein-induced injury: Involvement of mitochondrial function. Biochimie 105:172-81.LEAK
ROUTINE
ETS
Intact cellsBovinesOther cell lines
Beiral 2014 Cell Transplant2014Beiral HJ, Rodrigues-Ferreira C, Fernandes AM, Gonsalez SR, Mortari NC, Takiya CM, Sorenson MM, Figueiredo-Freitas C, Galina A, Vieyra A (2014) The impact of stem cells on electron fluxes, proton translocation and ATP synthesis in kidney mitochondria after ischemia/reperfusion. Cell Transplant 23:207-20.LEAK
OXPHOS
ETS
SIsolated mitochondriaRatKidney
Stem cells
Gnaiger 2014 MitoPathways2014
O2k-Protocols
Gnaiger E (2014) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 4th ed. Mitochondr Physiol Network 19.12. OROBOROS MiPNet Publications, Innsbruck:80 pp.
LEAK
ROUTINE
OXPHOS
ETS
F
N
S
Gp
CIV
NS
ROX
Intact cells
Permeabilized cells
Permeabilized tissue
Homogenate
Isolated mitochondria
Human
Mouse
Heart
Skeletal muscle
Fibroblast
Solinas 2014 Mech Ageing Dev2014Solinas P, Fujioka H, Radivoyevitch T, Tandler B, Hoppel CL (2014) Aging effects on oxidative phosphorylation in rat adrenocortical 3 mitochondria. Mech Ageing Dev 138:10-4.ETS
LEAK
OXPHOS
CIV
N
NS
S
Isolated mitochondriaRatKidney
Hirzel 2014 PhD Thesis2014Hirzel E (2014) Characterization of human bone marrow derived mesenchymal stem cells as a model for in vitro adipocytes studies. PhD Thesis 1-106.LEAK
ROUTINE
OXPHOS
ETS
N
NS
Intact cells
Permeabilized cells
HumanFat
Other cell lines
Uncoupler2014Gnaiger E (2014) Is respiration uncoupled - noncoupled - dyscoupled? Mitochondr Physiol Network 2014-04-18.LEAK
ETS
Brandt 2014 Chem Biol Interact2014Brandt AP, do Rocio Andrade Pires A, Rocha ME, Noleto GR, Acco A, de Souza CE, Echevarria A, Dos Santos Canuto AV, Cadena SM (2014) Sydnone SYD-1 affects the metabolic functions of isolated rat hepatocytes. Chem Biol Interact 218C:107-14.LEAK
ROUTINE
ETS
ROXIntact cellsRatLiver
Schoerner 2014 Thesis University Giessen2014Schörner S (2014) Changes in function of mitochondrial respiratory chain in pulmonary artery smooth muscle cells under conditions of chronic hypoxia : measurements by respirometry and remission-spectrophotometry. Thesis University Giessen 130 pp.LEAK
ROUTINE
ETS
ROXRabbitEndothelial;epithelial;mesothelial cell
DeLany 2014 J Clin Endocrinol Metab2014DeLany JP, Dube JJ, Standley RA, Distefano G, Goodpaster BH, Stefanovic-Racic M, Coen PM, Toledo FG (2014) Racial differences in peripheral insulin sensitivity and mitochondrial capacity in the absence of obesity. J Clin Endocrinol Metab 99:4307-14.LEAK
OXPHOS
ETS
Other combinationsPermeabilized tissueHumanSkeletal muscle
Hagl 2014 J Alzheimers Dis b2014Hagl S, Heinrich M, Kocher A, Schiborr C, Frank J, Eckert GP (2014) Curcumin micelles improve mitochondrial function in a mouse model of Alzheimer’s disease. J Alzheimers Dis 1:80-3.ETS
LEAK
OXPHOS
CIV
N
NS
ROX
S
Isolated mitochondriaMouseNervous system
Karabatsiakis 2014 Transl Psychiatry2014Karabatsiakis A, Böck C, Salinas-Manrique J, Kolassa S, Calzia E, Dietrich DE, Kolassa IT (2014) Mitochondrial respiration in peripheral blood mononuclear cells correlates with depressive subsymptoms and severity of major depression. Transl Psychiatry 4:e397.LEAK
ROUTINE
ETS
ROXIntact cellsHumanBlood cells
Lymphocyte
OXPHOS control ratio2014Gnaiger E (2014) P/E from mouse to man. Mitochondr Physiol Network 2014-05-20.OXPHOS
ETS
Porter 2014 Am J Physiol2014Porter C, Herndon DN, Børsheim E, Chao T, Reidy P, Borack M, Rasmussen BB, Chondronikola M, Saraf M, Sidossis LS (2014) Uncoupled skeletal muscle mitochondria contribute to hypermetabolism in severely burned adults. Am J Physiol 307:E462-7.ETS
LEAK
OXPHOS
N
NS
Permeabilized tissueHumanSkeletal muscle
Bayot 2014 Biochimie2014Bayot A, Gareil M, Chavatte L, Hamon MP, L'hermitte-Stead C, Beaumatin F, Priault M, Rustin P, Lombès A, Friguet B, Bulteau AL (2014) Effect of Lon protease knockdown on mitochondrial function in HeLa cells. Biochimie 100:38-47.LEAK
ROUTINE
ETS
HumanEndothelial;epithelial;mesothelial cell
HeLa
Jiroutkova 2014 Intensive Care Medicine Experimental2014Jiroutkova K, Ziak J, Krajcova A, Fric M, Dzupa V, Duska F (2014) The role of mitochondrial dysfunction in the pathophysiology of icu-acquired weakness. Intensive Care Med 2:29.LEAK
OXPHOS
ETS
N
S
HumanSkeletal muscle
Chini 2014 Clin Cancer Res2014Chini CC, Gonzalez Guerrico A, Nin V, Camacho-Pereira J, Escande C, Barbosa M, Chini EN (2014) Targeting of NAD metabolism in pancreatic cancer cells: potential novel therapy for pancreatic tumors. Clin Cancer Res 20:120-30.ROUTINE
ETS
Intact cellsHumanIslet cell;pancreas;thymus
Other cell lines
Matallo 2014 Nitric Oxide2014Matallo J, Vogt J, McCook O, Wachter U, Tillmans F, Groeger M, Szabo C, Georgieff M, Radermacher P, Calzia E (2014) Sulfide-inhibition of mitochondrial respiration at very low oxygen concentrations. Nitric Oxide 15:79-84.ROUTINE
ETS
Intact cellsMouseLung;gill
Macrophage-derived
Larsen 2014 Anal Biochem2014Larsen S, Kraunsøe R, Gram M, Gnaiger E, Helge JW, Dela F (2014) The best approach: homogenization or manual permeabilization of human skeletal muscle fibers for respirometry? Anal Biochem 446:64-8.LEAK
OXPHOS
ETS
N
NS
Permeabilized tissue
Homogenate
Human
Mouse
Skeletal muscle
Casanova 2014 Biochim Biophys Acta2014Casanova E, Baselga-Escudero L, Ribas-Latre A, Arola-Arnal A, Bladé C, Arola L, Salvadó MJ (2014) Epigallocatechin gallate counteracts oxidative stress in docosahexaenoxic acid-treated myocytes. Biochim Biophys Acta 1837:783-91.LEAK
ROUTINE
ETS
NIntact cellsRatSkeletal muscle
Other cell lines
Tippets 2014 BMC Cardiovasc Disord2014Tippetts TS, Winden DR, Swensen AC, Nelson MB, Thatcher MO, Saito RR, Condie TB, Simmons KJ, Judd AM, Reynolds PR, Bikman BT (2014) Cigarette smoke increases cardiomyocyte ceramide accumulation and inhibits mitochondrial respiration. BMC Cardiovasc Disord 14:165.LEAK
OXPHOS
ETS
N
S
NS
ROX
Permeabilized cells
Permeabilized tissue
Isolated mitochondria
Mouse
Rat
Heart
Other cell lines
Chicco 2014 J Exp Biol2014Chicco AJ, Le CH, Schlater AE, Nguyen AD, Kaye SD, Beals JW, Scalzo RL, Bell C, Gnaiger E, Costa DP, Crocker DE, Kanatous SB (2014) High fatty acid oxidation capacity and phosphorylation control despite elevated leak and reduced respiratory capacity in northern elephant seal muscle mitochondria. J Exp Biol 217:2947-55.LEAK
OXPHOS
ETS
F
N
S
NS
Permeabilized tissueHuman
Other mammals
Skeletal muscle
Afshordel 2014 Prostaglandins Leukot Essent Fatty Acids2014Afshordel S, Hagl S, Werner D, Roehner N, Koegel D, Bazan NG, Eckert GP (2014) Omega-3 polyunsaturated fatty acids improve mitochondrial dysfunction in brain aging - impact of Bcl-2 and NPD-1 like metabolites. Prostaglandins Leukot Essent Fatty Acids 92:23-31.LEAK
OXPHOS
ETS
N
S
CIV
NS
ROX
Isolated mitochondriaMouseNervous system
Onukwufor 2013 J Exp Biol2014Onukwufor JO, Macdonald N, Kibenge F, Stevens D, Kamunde C (2013) Hypoxia-cadmium interactions on rainbow trout (Oncorhynchus mykiss) mitochondrial bioenergetics: attenuation of hypoxia-induced proton leak by low doses of cadmium. J Exp Biol 217:831-40.LEAK
OXPHOS
ETS
NIsolated mitochondriaFishesLiver
Cordero-Reyes 2014 J Mol Cell Cardiol2014Cordero-Reyes AM, Gupte AA, Youker KA, Loebe M, Hsueh WA, Torre-Amione G, Taegtmeyer H, Hamilton DJ (2014) Freshly isolated mitochondria from failing human hearts exhibit preserved respiratory function. J Mol Cell Cardiol 68:98-105.LEAK
OXPHOS
ETS
N
S
ROX
Isolated mitochondriaHumanHeart
Nunez-Figueredo 2014 Brain Res Bull2014Nunez-Figueredo Y, Pardo-Andreu GL, Ramirez-Sanchez J, Delgado-Hernandez R, Ochoa-Rodriguez E, Verdecia-Reyes Y, Naal Z, Muller AP, Portela LV, Souza DO (2014) Antioxidant effects of JM-20 on rat brain mitochondria and synaptosomes: Mitoprotection against Ca2+-induced mitochondrial impairment. Brain Res Bull 109:68-76.ETSN
S
Isolated mitochondriaRatNervous system
Van Bergen 2014 Mitochondrion2014Van Bergen NJ, Blake RE, Crowston JG, Trounce IA (2014) Oxidative phosphorylation measurement in cell lines and tissues. Mitochondrion 15:24-33.LEAK
ROUTINE
OXPHOS
ETS
N
S
NS
Intact cells
Permeabilized cells
Isolated mitochondria
Human
Mouse
Nervous system
Blood cells
Lymphocyte
Davoudi 2014 PhD Thesis2014Davoudi M (2014) Effect of experimental complex III deficiency on respiratory chain assembly and function. PhD Thesis 1-65.LEAK
OXPHOS
ETS
N
S
Isolated mitochondriaMouseLiver
Wessels 2014 PLoS One2014Wessels B, Ciapaite J, van den Broek NMA, Nicolay K, Prompers JJ (2014) Metformin Impairs Mitochondrial Function in Skeletal Muscle of Both Lean and Diabetic Rats in a Dose-Dependent Manner. PLoS One 9:e100525.LEAK
OXPHOS
ETS
N
S
Isolated mitochondriaRatSkeletal muscle
Cedikova 2014 Evid Based Complement Alternat Med2014Cedikova M, Miklikova M, Stachova L, Grundmanova M, Tuma Z, Vetvicka V, Zech N, Kralickova M, Kuncova J (2014) Effects of the Czech propolis on sperm mitochondrial function. Evid Based Complement Alternat Med 248768.LEAK
OXPHOS
ETS
F
N
S
CIV
NS
ROX
Permeabilized cellsHumanGenital
Corona 2014 Exp Neurol2014Corona JC, de Souza SC, Duchen MR (2014) PPARγ activation rescues mitochondrial function from inhibition of 2 complex I and loss of PINK1. Exp Neurol 253:16-27.LEAK
ROUTINE
ETS
Intact cellsHumanNeuroblastoma
Thatcher 2014 Am J Physiol Endocrinol Metab2014Thatcher MO, Tippetts TS, Nelson MB, Swensen AC, Winden DR, Hansen ME, Anderson MC, Johnson IE, Porter JP, Reynolds PR, Bikman BT (2014) Ceramides mediate cigarette smoke-induced metabolic disruption in mice. Am J Physiol Endocrinol Metab 307:E919-27.LEAK
OXPHOS
ETS
N
S
NS
ROX
Permeabilized cells
Permeabilized tissue
Human
Mouse
Skeletal muscle
Zachariah 2014 Diabetes2014Zachariah Tom R, Garcia-Roves PM, Sjögren RJ, Jiang LQ, Holmström MH, Deshmukh AS, Vieira E, Chibalin AV, Björnholm M, Zierath JR (2014) Effects of AMPK activation on insulin sensitivity and metabolism in leptin-deficient ob/ob mice. Diabetes 63:1560-71.ETS
LEAK
OXPHOS
N
NS
Permeabilized tissueMouseSkeletal muscle
Rossato 2014 PLoS One2014Rossato FA, Zecchin KG, La Guardia PG, Ortega RM, Alberici LC, Costa RA, Catharino RR, Graner E, Castilho RF, Vercesi AE (2014) Fatty acid synthase inhibitors induce apoptosis in non-tumorigenic Melan-A cells associated with inhibition of mitochondrial respiration. PLoS One 9:e101060.LEAK
OXPHOS
ETS
N
S
CIV
NS
Intact cells
Permeabilized cells
MouseEndothelial;epithelial;mesothelial cell
Other cell lines
Shama 2014 Funct Ecol2014Shama LNS, Strobel A, Mark FC, Wegner KM (2014) Transgenerational plasticity in marine sticklebacks: maternal effects mediate impacts of a warming ocean. Funct Ecol 28:1482–93.LEAK
OXPHOS
ETS
N
ROX
Permeabilized tissueFishesHeart
Mourier 2014 Hum Mol Genet2014Mourier A, Ruzzenente B, Brandt T, Kühlbrandt W, Larsson NG (2014) Loss of LRPPRC causes ATP synthase deficiency. Hum Mol Genet 23:2580-92.LEAK
OXPHOS
ETS
N
S
Isolated mitochondriaMouseHeart
Di Noia 2014 J Biol Chem2014Di Noia MA, Todisco S, Cirigliano A, Rinaldi T, Agrimi G, Iacobazzi V, Palmieri F (2014) The human SLC25A33 and SLC25A36 genes of solute carrier family 25 encode two mitochondrial pyrimidine nucleotide transporters. J Biol Chem 289:33137-48.ROUTINE
ETS
Intact cellsSaccharomyces cerevisiae
Konickova 2014 Annals Hepatol2014Konickova R, Vankova K, Vanikova J, Vanova K, Muchova L, Subhanova I, Zadoinova M, Zelenka J, Dvorak A, Kolar M,Strnad H, Rimpelova S, Ruml T, Wong RJ, Vitek L (2014) Anti-cancer effects of blue-green alga Spirulina platensis, a natural source of bilirubin-like tetrapyrrolic compounds. Annals Hepatol 13:273-83.ROUTINE
ETS
HumanOther cell lines
Baggio 2014 Nucleic Acids Res2014Baggio F, Bratic A, Mourier A, Kauppila TE, Tain LS, Kukat C, Habermann B, Partridge L, Larsson NG5 (2014) Drosophila melanogaster LRPPRC2 is involved in coordination of mitochondrial translation. Nucleic Acids Res 42:13920-38.LEAK
OXPHOS
ETS
N
S
Gp
CIV
Other combinations
Permeabilized tissueDrosophila
Hexapods
Felser 2014 Toxicology II2014Felser A, Lindinger PW, Schnell D, Kratschmar DV, Odermatt A, Mies S, Jenö P, Krähenbühl S (2014) Hepatocellular toxicity of benzbromarone: effects on mitochondrial function and structure. Toxicology 324:136-46.LEAK
ROUTINE
OXPHOS
ETS
N
S
ROX
Intact cellsHumanLiver
Other cell lines
Casanova 2014 J Nutr Biochem2014Casanova E, Baselga-Escudero L, Ribas-Latre A, Cedó L, Arola-Arnal A, Pinent M, Bladé C, Arola L, Salvadó MJ (2014) Chronic intake of proanthocyanidins and docosahexaenoic acid improves skeletal muscle oxidative capacity in diet-obese rats. J Nutr Biochem 25:1003–10.LEAK
OXPHOS
ETS
F
N
S
NS
Isolated mitochondriaRatSkeletal muscle
Schiffer 2014 FASEB J2014Schiffer TA, Ekblom B, Lundberg JO, Weitzberg E, Larsen FJ (2014) Dynamic regulation of metabolic efficiency explains tolerance to acute hypoxia in humans. FASEB J 28:4303-11.LEAK
OXPHOS
ETS
N
S
Isolated mitochondriaHumanSkeletal muscle
Ambrosio 2014 Free Radic Biol Med2014Ambrosio F, Brown E, Stolz D, Ferrari R, Goodpaster BH, Deasy B, Distefano G, Roperti A, Cheikhi A, Garciafigueroa Y, Barchowsky A (2014) Arsenic induces sustained impairment of skeletal muscle and muscle progenitor cell ultrastructure and bioenergetics. Free Radic Biol Med 74C:64-73.LEAK
OXPHOS
ETS
F
N
NS
Permeabilized tissueMouseSkeletal muscle
Koenemann 2014 Dissertation2014Koenemann B (2014) Einfluss der Hyperglykämie auf die mitochondriale Atmung von Leberzellen septischer Mäuse mit und ohne Imeglimin. PhD Thesis 1-61.LEAK
OXPHOS
ETS
F
N
S
NS
Other combinations
ROX
HomogenateMouseLiver
Chu 2014 Liver Transpl2014Chu MJ, Hickey AJ, Jiang Y, Petzer A, Bartlett AS, Phillips AR (2014) Mitochondrial dysfunction in rat steatotic liver is due to a defect in Complex-I making them more susceptible to prolonged cold ischemia. Liver Transpl 21:396-407.LEAK
OXPHOS
ETS
N
S
ROX
HomogenateRatLiver
Sjoevall 2014 PLoS One2014Sjövall F, Morota S, Asander Frostner E, Hansson Magnus J, Elmer E (2014) Cytokine and nitric oxide levels in patients with sepsis - temporal evolvement and relation to platelet mitochondrial respiratory function. PLoS One 9:e97673.LEAK
OXPHOS
ETS
N
S
CIV
NS
ROX
Permeabilized cellsBlood cells
Platelet
Fiuza 2014 Free Radic Res2014Fiuza B, Subelzú N, Calcerrada P, Straliotto MR, Piacenza L, Cassina A, Rocha JB, Radi R, de Bem AF, Peluffo G (2014) Impact of SIN-1-derived peroxynitrite flux on endothelial cell redox homeostasis and bioenergetics: protective role of diphenyl diselenide via induction of peroxiredoxins. Free Radic Res 49:122-32.LEAK
ROUTINE
ETS
Intact cellsBovinesEndothelial;epithelial;mesothelial cell
Carriere 2014 Diabetes2014Carrière A, Jeanson Y, Berger-Müller S, André M, Chenouard V, Arnaud E, Barreau C, Walther R, Galinier A, Wdziekonski B, Villageois P, Louche K, Collas P, Moro C, Dani C, Villarroya F, Casteilla L (2014) Browning of white adipose cells by intermediate metabolites: an adaptive mechanism to alleviate redox pressure. Diabetes 63:3253-65.LEAK
ROUTINE
ETS
Intact cellsMouseFat
Hoevenaars 2014 Mol Nutr Food Res2014Hoevenaars FP, Bekkenkamp-Grovenstein M, Janssen RJ, Heil SG, Bunschoten A, Hoek-van den Hil EF, Snaas-Alders S, Teerds K, van Schothorst EM, Keijer J (2014) Thermoneutrality results in prominent diet-induced body weight differences in C57BL/6J mice, not paralleled by diet-induced metabolic differences. Mol Nutr Food Res 58:799-807.LEAK
OXPHOS
ETS
N
NS
Isolated mitochondriaMouseSkeletal muscle
Slinde 2014 freepatentsonline.com2014Slinde E, Egelandsdal B (2014) Meat treatment and preservation method. Freepatentsonline.com 14/128207.LEAK
OXPHOS
ETS
F
N
NS
ROX
Permeabilized tissueBovinesSkeletal muscle
Glaser 2014 Thesis2014Glaser V (2014) Efeitos da hiperglicemia cronica e seus metabolitos, metilglioxal e produtos terminais de glicacao, na fisiologia e dinamica mitochondrial no sistema nervoso central. PhD Thesis 1-117.LEAK
ROUTINE
ETS
ROXIntact cellsRatNervous system
Other cell lines
Logan 2014 Nat Genet2014Logan CV, Szabadkai G, Sharpe JA, Parry DA, Torelli S, Childs AM, Kriek M, Phadke R, Johnson CA, Roberts NY, Bonthron DT, Pysden KA, Whyte T, Munteanu I, Foley AR, Wheway G, Szymanska K, Natarajan S, Abdelhamed ZA, Morgan JE, Roper H, Santen GW, Niks EH, van der Pol WL, Lindhout D, Raffaello A, De Stefani D, den Dunnen JT, Sun Y, Ginjaar I, Sewry CA, Hurles M, Rizzuto R. UK10K Consortium, Duchen MR, Muntoni F, Sheridan E (2014) Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling. Nat Genet 46:188-93.LEAK
ROUTINE
ETS
ROXIntact cellsHumanFibroblast
Garnol 2014 Physiol Res2014Garnol T, Endlicher R, Kučera O, Drahota Z, Cervinková Z (2014) Impairment of mitochondrial function of rat hepatocytes by high fat diet and oxidative stress. Physiol Res 63:271-4.LEAK
OXPHOS
ETS
N
S
Intact cells
Permeabilized cells
Isolated mitochondria
RatLiver
Serteyn 2014 Bioenergetics2014Serteyn D, de la Rebière de Pouyade G, Sandersen C, Salciccia A, Grulke S, Mouithys-Mickalad A, Franck T, Lejeune JP, Ceusters Justine D (2014) Muscle mitochondrial dysfunction in horses affected by acute laminitis. Bioenergetics 3:1-7.LEAK
OXPHOS
ETS
N
S
NS
ROX
Permeabilized tissueHorseSkeletal muscle
Chakraborty 2014 J Cardiovasc Dis2014Chakraborty M, Phillips ARJ, Macdonald J, Windsor JA, Hickey AJR (2014) Mitochondrial respiration in mononuclear cells and heart fibers in spontaneously hypertensive rats. J Cardiovasc Dis ISSN:2330-459.LEAK
ROUTINE
OXPHOS
ETS
N
S
Gp
CIV
NS
ROX
Permeabilized cells
Permeabilized tissue
RatHeart
Blood cells
Echevarría 2014 Biochem J2014Echevarría L, Clemente P, Hernández Sierra R, Gallardo ME, Fernández-Moreno MA, Garesse R (2014) Mammalian GatCAB is essential for mitochondrial translation 1 Glutamyl-tRNAGln amidotransferase is essential for mammalian mitochondrial translation in vivo. Biochem J 460:91-101.LEAK
ETS
NIntact cellsHuman
Mouse
Other cell lines
HEK
HeLa
Jelenik 2014 Diabetes2014Jelenik T, Séquaris G, Kaul K, Ouwens DM, Phielix E, Kotzka J, Knebel B, Weiß J, Reinbeck AL, Janke L, Nowotny P, Partke HJ, Zhang D, Shulman GI, Szendroedi J, Roden M (2014) Tissue-specific differences in the development of insulin resistance in a mouse model for type 1 diabetes. Diabetes 63:3856-67.OXPHOS
ETS
N
NS
ROX
Permeabilized tissue
Isolated mitochondria
MouseSkeletal muscle
Liver
Iftikar 2014 Thesis University of Auckland2014Iftikar FI (2014) Testing the role of heart mitochondrial stability and function in heart failure of ectotherms exposed to heat stress. Thesis University of Auckland:167pp.ETS
LEAK
OXPHOS
CIV
N
NS
ROX
Permeabilized tissueFishesHeart
Broeker 2014 Thesis2014Broeker C (2014) Mitochondriopathien als Ursache des renalen Fanconi-Syndroms. Dissertation 85pp.LEAK
OXPHOS
ETS
N
CIV
NS
ROX
Permeabilized cellsPigKidney
Other cell lines
Brahma 2014 J Lipid Res2014Brahma MK, Adam RC, Pollak NM, Jaeger D, Zierler KA, Poecher N, Schreiber R, Romauch M, Moustafa T, Eder S, Ruelicke T, Preiss-Landl K, Lass A, Zechner R, Haemmerle G (2014) Fibroblast growth factor 21 is induced upon cardiac stress and alters cardiac lipid homeostasis. J Lipid Res 55:2229-41.LEAK
ROUTINE
ETS
Intact cellsMouse
Rat
Heart
Grimpo 2014 Comp Biochem Physiol A Mol Integr Physiol2014Grimpo K, Kutschke M, Kastl A, Meyer CW, Heldmaier G, Exner C, Jastroch M (2014) Metabolic depression during warm torpor in the Golden spiny mouse (Acomys russatus) does not affect mitochondrial respiration and hydrogen peroxide release. Comp Biochem Physiol A Mol Integr Physiol 167:7-14.LEAK
OXPHOS
ETS
SIsolated mitochondriaOther mammalsHeart
Skeletal muscle
Liver
Kidney
Castelein 2014 Exp Gerontol2014Castelein N, Muschol M, Dhondt I, Cai H, De Vos WH, Dencher NA, Braeckman BP (2014) Mitochondrial efficiency is increased in axenically cultured Caenorhabditis elegans. Exp Gerontol 56:26-36.LEAK
OXPHOS
ETS
N
S
NS
Isolated mitochondriaCaenorhabditis elegans
Doerrier 2014 Life Sci2014Doerrier C, García JA, Volt H, Díaz-Casado ME, Lima-Cabello E, Ortiz F, Luna-Sánchez M, Escames G, López LC, Acuña-Castroviejo D (2014) Identification of mitochondrial deficits and melatonin targets in liver of septic mice by high-resolution respirometry. Life Sci 121:158-65.LEAK
OXPHOS
ETS
N
S
NS
Homogenate
Isolated mitochondria
MouseLiver
Doridot 2014 Antioxid Redox Signal2014Doridot LD Chatre LD, Ducat A, Vilotte JL, Lombes A, Méhats C, Barbaux S, Calicchio R, Ricchetti M, Vaiman D (2014) Nitroso-redox balance and mitochondrial homeostasis are regulated by STOX1, a pre-eclampsia associated gene. Antioxid Redox Signal 21:819-34.LEAK
ROUTINE
ETS
ROXHumanEndothelial;epithelial;mesothelial cell
Other cell lines
Divakaruni 2014 Curr Protoc Toxicol2014Divakaruni AS, Rogers GW, Murphy AN (2014) Measuring mitochondrial function in permeabilized cells using the Seahorse XF Analyzer or a clark-type oxygen electrode. Curr Protoc Toxicol 60:25.2.1-25.2.16.LEAK
OXPHOS
ETS
F
N
S
Gp
CIV
ROX
Permeabilized cellsMouseSkeletal muscle
Other cell lines
Vigueira 2014 Cell Rep2014Vigueira PA, McCommis KS, Schweitzer GG, Remedi MS, Chambers KT, Fu X, McDonald WG, Cole SL, Colca JR, Kletzien RF, Burgess SC, Finck BN (2014) Mitochondrial pyruvate carrier 2 hypomorphism in mice leads to defects in glucose-stimulated insulin secretion. Cell Rep 7:2042-53.ETSN
S
Isolated mitochondriaMouseHeart
Kidney
Hecker 2014 JPEN2014Hecker M, Sommer N, Voigtmann H, Pak O, Mohr A, Wolf M, Vadász I, Herold S, Weissmann N, Morty R, Seeger W, Mayer K (2014) Impact of short- and medium-chain fatty acids on mitochondrial function in severe inflammation. J Parenter Enteral Nutr 38:587-94.LEAK
ROUTINE
ETS
Intact cellsHumanEndothelial;epithelial;mesothelial cell
Blood cells
HUVEC
Chu 2014 PLoS One2014Chu MJ, Hickey AJ, Tagaloa S, Zhang L, Dare AJ, MacDonald JR, Yeong ML, Bartlett AS, Phillips AR (2014) Ob/ob mouse livers show decreased oxidative phosphorylation efficiencies and anaerobic capacities after cold ischemia. PLoS One 9:e100609.LEAK
OXPHOS
ETS
N
S
CIV
NS
Permeabilized tissueMouseLiver
Phielix 2014 Diabetologia2014Phielix E, Jelenik T, Nowotny P, Szendroedi J, Roden M (2014) Reduction of non-esterified fatty acids improves insulin sensitivity and lowers oxidative stress, but fails to restore oxidative capacity in type 2 diabetes: a randomised clinical trial. Diabetologia 57:572-81.LEAK
OXPHOS
ETS
N
NS
Permeabilized tissue
Isolated mitochondria
HumanSkeletal muscle
Cheng 2014 Science2014Cheng SC, Quintin J, Cramer RA, Shepardson KM, Saeed S, Kumar V, Giamarellos-Bourboulis EJ, Martens JH, Rao NA, Aghajanirefah A, Manjeri GR6, Li Y, Ifrim DC, Arts RJ, van der Meer BM, Deen PM, Logie C, O'Neill LA, Willems P, van de Veerdonk FL, van der Meer JW, Ng A, Joosten LA, Wijmenga C, Stunnenberg HG, Xavier RJ, Netea MG (2014) mTOR- and HIF-1 α –mediated aerobic glycolysis as metabolic basis for trained immunity. Science 345:1250684.LEAK
ROUTINE
ETS
HumanBlood cells
Other cell lines
LEAK respiration2014Gnaiger E (2014) LEAK respiration: concept-linked terminology of respiratory states. Mitochondr Physiol Network 2014-07-04.LEAK
ETS
Garratt 2014 Proc Natl Acad Sci U S A2014Garratt M, Pichaud N, Glaros EN, Kee AJ, Brooks RC (2014) Superoxide dismutase deficiency impairs olfactory sexual signaling and alters bioenergetic function in mice. Proc Natl Acad Sci U S A 111:8119-24.LEAK
OXPHOS
ETS
F
N
S
CIV
NS
ROX
Permeabilized tissueMouseLiver
De Palma 2014 Skelet Muscle2014De Palma C, Morisi F, Pambianco S, Assi E, Touvier T, Russo S, Perrotta C, Romanello V, Carnio S, Cappello V, Pellegrino P, Moscheni C, Bassi MT, Sandri M, Cervia D, Clementi E (2014) Deficient nitric oxide signalling impairs skeletal muscle growth and performance: involvement of mitochondrial dysregulation. Skelet Muscle 4:22.ETS
LEAK
OXPHOS
CIV
N
NS
S
Isolated mitochondria
Permeabilized tissue
MouseSkeletal muscle
Khan 2014 J Comp Physiol2014Khan JR, Iftikar FI, Herbert NA, Gnaiger E, Hickey AJ (2014) Thermal plasticity of skeletal muscle mitochondrial activity and whole animal respiration in a common intertidal triplefin fish, Forsterygion lapillum (Family: Tripterygiidae). J Comp Physiol 184:991-1001.LEAK
OXPHOS
ETS
N
S
NS
ROX
Permeabilized tissueFishesSkeletal muscle
Zambrano 2014 J Cell Biol2014Zambrano A, García-Carpizo V, Gallardo ME, Villamuera R, Gómez-Ferrería MA, Pascual A, Buisine N, Sachs LM, Garesse R, Aranda A (2014) The thyroid hormone receptor induces DNA damage and premature senescence. J Cell Biol 204:129-46.LEAK
OXPHOS
ETS
N
ROX
Intact cellsMouse
Rudnicki 2014 United States Patent Application Publication2014Rudnicki MA, Yin Hang (2014) MICRORNA INHIBITORS. United States Patent Application Publication 1-49.LEAK
ROUTINE
OXPHOS
ETS
F
N
S
NS
ROX
Intact cells
Permeabilized cells
MouseSkeletal muscle
Fat
Cotoia 2014 PLoS One2014Cotoia A, Scrima R, Gefter JV, Piccoli C, Cinnella G, Dambrosio M, Fink MP, Capitanio N (2014) p-Hydroxyphenylpyruvate, an intermediate of the Phe/ Tyr catabolism, improves mitochondrial oxidative metabolism under stressing conditions and prolongs survival in rats subjected to profound hemorrhagic shock. PLoS One 9:e90917.LEAK
ROUTINE
ETS
Intact cellsRat
Montaigne 2014 Circulation2014Montaigne D, Marechal X, Coisne A, Debry N, Modine T, Fayad G, Potelle C, El Arid JM, Mouton S, Sebti Y, Duez H, Preau S, Remy-Jouet I, Zerimech F, Koussa M, Richard V, Neviere R, Edme JL, Lefebvre P, Staels B (2014) Myocardial contractile dysfunction is associated with impaired mitochondrial function and dynamics in Type 2 Diabetic but not in obese patients. Circulation 130:554-64.LEAK
OXPHOS
ETS
F
N
S
CIV
NS
Permeabilized tissueHumanHeart
Fletcher 2014 Med Sci Sports Exerc2014Fletcher JA, Meers GM, Linden MA, Kearney ML, Morris EM, Thyfault JP, Rector RS (2014) Impact of various exercise modalities on hepatic mitochondrial function. Med Sci Sports Exerc 46:1089-97.LEAK
OXPHOS
ETS
N
S
NS
Isolated mitochondriaRatLiver
Abdurrachim 2014 Biochim Biophys Acta2014Abdurrachim D, Ciapaite J, Wessels B, Nabben M, Luiken JJ, Nicolay K, Prompers JJ (2014) Cardiac diastolic dysfunction in high-fat diet fed mice is associated with lipotoxicity without impairment of cardiac energetics in vivo. Biochim Biophys Acta 1842:1525-37.LEAK
OXPHOS
ETS
F
N
Isolated mitochondriaMouseHeart
Fisar 2014 Toxicol Lett2014Fišar Z, Singh N, Hroudová J (2014) Cannabinoid-induced changes in respiration of brain mitochondria. Toxicol Lett 231:62-71.LEAK
OXPHOS
ETS
N
S
CIV
ROX
Isolated mitochondriaPigNervous system
Miquel 2014 Free Radic Biol Med2014Miquel E, Cassina A, Martínez-Palma L, Souza JM, Bolatto C, Rodríguez-Bottero S, Logan A, Smith RA, Murphy MP, Barbeito L, Radi R, Cassina P (2014) Neuroprotective effects of the mitochondria-targeted antioxidant MitoQ in a model of inherited amyotrophic lateral sclerosis. Free Radic Biol Med 70:204-13.LEAK
OXPHOS
ETS
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Nervous system
Kivelae 2014 EMBO Mol Med2014Kivelä R, Bry M, Robciuc MR, Räsänen M, Taavitsainen M, Silvola JM, Saraste A, Hulmi JJ, Anisimov A, Mäyränpää MI, Lindeman JH, Eklund L, Hellberg S, Hlushchuk R, Zhuang ZW, Simons M, Djonov V, Knuuti J, Mervaala E, Alitalo K (2016) VEGF-B-induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart. EMBO Mol Med 6:307-21.LEAK
OXPHOS
ETS
F
N
S
HomogenateRatHeart
Ost 2014 PLoS One2014Ost M, Werner F, Dokas J, Klaus S, Voigt A (2014) Activation of AMPKa2 is not crucial for mitochondrial uncoupling-induced metabolic effects but required to maintain skeletal muscle integrity. PLoS One 14:e94689.LEAK
OXPHOS
ETS
F
N
NS
Permeabilized tissueMouseSkeletal muscle
Den Hollander 2014 Toxicol Sci2014den Hollander B, Sundström M, Pelander A, Ojanperä I, Mervaala E, Korpi ER, Kankuri E (2014) Keto amphetamine toxicity - focus on the redox reactivity of the cathinone designer drug mephedrone. Toxicol Sci 141:120-31.LEAK
OXPHOS
ETS
N
S
NS
ROX
HomogenateMouseNervous system
Valenti 2014 Anal Biochem2014Valenti D, de Bari L, De Filippis B, Ricceri L, Vacca RA (2014) Preservation of mitochondrial functional integrity in mitochondria isolated from small cryopreserved mouse brain areas. Anal Biochem 444:25-31.ETS
OXPHOS
N
ROX
S
Isolated mitochondriaMouseNervous system
Damiano 2014 PLoS One2014Damiano M, Gautier CA, Bulteau AL, Ferrando-Miguel R, Gouarne C, Paoli MG, Pruss R, Auchère F, L'Hermitte-Stead C, Bouillaud F, Brice A, Corti O, Lombès A (2014) Tissue- and cell-specific mitochondrial defect in Parkin- deficient mice. PLoS One 9:e99898.LEAK
OXPHOS
ETS
N
ROX
Isolated mitochondriaMouseNervous system
Davoudi 2014 PLoS One2014Davoudi M, Kotarsky H, Hansson E, Fellman V (2014) Complex I function and supercomplex formation are preserved in liver mitochondria despite progressive Complex III deficiency. PLoS One 9:e86767.LEAK
OXPHOS
ETS
N
S
ROX
Isolated mitochondriaMouseLiver
Van Bree 2014 PhD Thesis2014van Bree B (2014) Mitochondria, lipotoxicity and skeletal muscle metabolism: implications for type 2 diabetes mellitus. PhD Thesis 1-150.LEAK
OXPHOS
ETS
F
N
Isolated mitochondriaMouseSkeletal muscle
Diana 2014 Ann Surg2014Diana M, Noll E, Diemunsch P, Dallemagne B, Benahmed MA, Agnus V, Soler L, Barry B, Namer IJ, Demartines N, Charles AL, Geny B, Marescaux J (2014) Enhanced-reality video fluorescence: a real-time assessment of intestinal viability. Ann Surg 259:700-7.ETSN
S
CIV
Other combinations
Intact cellsPigEndothelial;epithelial;mesothelial cell
Piel 2014 Acta Physiol (Oxf)2014Piel S, Ehinger JK, Elmér E, Hansson Magnus J (2014) Metformin induces lactate production in peripheral blood mononuclear cells and platelets through specific mitochondrial complex I inhibition. Acta Physiol (Oxf) 213:171-80.LEAK
ROUTINE
OXPHOS
ETS
N
S
CIV
NS
ROX
Intact cells
Permeabilized cells
HumanBlood cells
Other cell lines
Platelet
Boczek 2014 Biomed Res Int2014Boczek T, Lisek M, Ferenc B, Kowalski A, Wiktorska M, Zylinska L (2014) Silencing of plasma membrane Ca2+-ATPase isoforms 2 and 3 impairs energy metabolism in differentiating PC12 cells. Biomed Res Int 2014:735106.LEAK
ROUTINE
ETS
RatNervous system
Other cell lines
Hasenour 2014 J Biol Chem2014Hasenour CM, Ridley DE, Hughey CC, James FD, Donahue EP, Shearer J, Viollet B, Foretz M, Wasserman DH (2014) 5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR) effect on glucose production, but not energy metabolism, is independent of hepatic AMPK in vivo. J Biol Chem 289:5950-9.LEAK
OXPHOS
ETS
N
ROX
Isolated mitochondriaMouseLiver
Iglesias-Gonzalez 2014 PhD Thesis2014Iglesias-Gonzalez J (2014) Neurotoxicity induced by oxidative stress and aluminium in relation to Parkinson’s disease: a mitochondrial bioenergetic approach by high-resolution respirometry. PhD Thesis 1-242.LEAK
OXPHOS
ETS
N
S
NS
ROX
Isolated mitochondriaHumanNervous system
Krumschnabel 2014 Methods Enzymol2014
O2k-Protocols contents
Krumschnabel G, Eigentler A, Fasching M, Gnaiger E (2014) Use of safranin for the assessment of mitochondrial membrane potential by high-resolution respirometry and fluorometry. Methods Enzymol 542:163-81.
LEAK
OXPHOS
ETS
N
S
ROX
HomogenateMouseNervous system
Stephenson 2013 Thesis Royal Melbourne Institute of Technology - Melbourne2013Stephenson EJ (2013) Mitochondrial function in metabolic health. Thesis Royal Melbourne Institute of Technology - Melbourne: 106pp.LEAK
OXPHOS
ETS
N
S
NS
ROX
Permeabilized tissueRatSkeletal muscle
Montaigne 2013 J Am Coll Cardiol2013Montaigne D, Marechal X, Lefebvre P, Modine T, Fayad G, Dehondt H, Hurt C, Coisne A, Koussa M, Remy-Jouet I, Zerimech F, Boulanger E, Lacroix D, Staels B, Neviere R (2013) Mitochondrial dysfunction as an arrhythmogenic substrate. J Am Coll Cardiol 62:1466-73.LEAK
OXPHOS
ETS
N
S
Permeabilized tissueHumanHeart
Hara 2013 Eur J Anaesthesiol2013Hara N, Karlsson M, Sjövall F, Hansson Magnus J, Elmér E, Uchino H (2013) Early brain mitochondrial dysfunction in a mouse model of sepsis: 7AP4‐9. Eur J Anaesthesiol 30,112-112.LEAK
OXPHOS
ETS
N
S
CIV
NS
HomogenateMouseNervous system
Casanova 2013 Thesis Universitat Rovira i Virgili - Spain2013Casanova Vallvé E (2013) Modulation of Mmuscle energy metabolism by bioactive compounds. Thesis Universitat Rovira i Virgili - Spain 117pp.ROUTINE
ETS
N
S
NS
ROX
Intact cellsRatSkeletal muscle
Beaudoin 2013 Am J Physiol Regul Integr Comp Physiol2013Beaudoin MS, Snook LA, Arkell AM, Simpson JA, Holloway GP, Wright DC (2013) Resveratrol supplementation improves white adipose tissue function in a depot-specific manner in Zucker diabetic fatty rats. Am J Physiol Regul Integr Comp Physiol 305:542-51.LEAK
OXPHOS
ETS
N
NS
Permeabilized cellsRatFat
Kushnareva 2013 Cell Death Differ2013Kushnareva YE, Gerencser AA, Bossy B, Ju WK, White AD, Waggoner J, Ellisman MH, Perkins G, Bossy-Wetzel E (2013) Loss of OPA1 disturbs cellular calcium homeostasis and sensitizes for excitotoxicity. Cell Death Differ 20:353-65.LEAK
ROUTINE
OXPHOS
ETS
N
S
Intact cells
Permeabilized cells
HumanEndothelial;epithelial;mesothelial cell
HeLa
Munro 2013 Aging Cell2013Munro D, Pichaud N, Paquin F, Kemeid V, Blier PU (2013) Low hydrogen peroxide production in mitochondria of the long-lived Arctica islandica: underlying mechanisms for slow aging. Aging Cell 12:5845-92.LEAK
OXPHOS
ETS
N
S
CIV
NS
ROX
Isolated mitochondriaOther invertebratesEndothelial;epithelial;mesothelial cell
Vijgen 2013 Surg Obes Relat Dis2013Vijgen GH, Bouvy ND, Hoeks J, Wijers S, Schrauwen P, van Marken Lichtenbelt WD (2013) Impaired skeletal muscle mitochondrial function in morbidly obese patients is normalized one year after bariatric surgery. Surg Obes Relat Dis 9:936-41.LEAK
OXPHOS
ETS
N
NS
Permeabilized tissueHumanSkeletal muscle
Pichaud 2013 J Exp Biol2013Pichaud N, Garratt M, Ballard JWO, Brooks RC (2013) Physiological adaptations to reproduction II. Mitochondrial adjustments in livers of lactating mice. J Exp Biol 216:2889-95.LEAK
OXPHOS
ETS
N
S
NS
ROX
Permeabilized tissueMouseLiver
Hall 2013 Biochim Biophys Acta2013Hall A, Larsen AK, Parhamifar L, Meyle KD, Wu LP, Moghimi SM (2013) High-resolution respirometry analysis of polyethylenimine-mediated mitochondrial energy crisis and cellular stress: Mitochondrial proton leak and inhibition of the electron transport system. Biochim Biophys Acta 1827:1213-25.LEAK
ROUTINE
OXPHOS
ETS
N
S
CIV
ROX
Isolated mitochondria
SMP
MouseLiver
Other cell lines
Hirzel 2013 J Recept Signal Transduct Res2013Hirzel E, Lindinger PW, Maseneni S, Giese M, Rhein VV, Eckert A, Hoch M, Krähenbühl S, Eberle AN (2013) Differential modulation of ROS signals and other mitochondrial parameters by the antioxidants MitoQ, resveratrol and curcumin in human adipocytes. J Recept Signal Transduct Res 33:304-12.ETS
ROUTINE
N
NS
Permeabilized cellsHumanFat
Other cell lines
Ceusters 2013 Mitochondrion2013Ceusters Justine D, Mouithys-Mickalad AA, Franck TJ, Derochette S, Vanderplasschen A, Deby-Dupont GP, Serteyn DA (2013) Effect of myeloperoxidase and anoxia/reoxygenation on mitochondrial respiratory function of cultured primary equine skeletal myoblasts. Mitochondrion 13:410-16.ETS
LEAK
OXPHOS
ROUTINE
Permeabilized cellsHorseSkeletal muscle
Dickinson 2013 Cell Death Differ2013Dickinson A, Yeung KY, Donoghue J, Baker MJ, Kelly RDW, McKenzie M, Johns TG, St. John JC (2013) The regulation of mitochondrial DNA copy number in glioblastoma cells. Cell Death Differ 20:1644–53.LEAK
ROUTINE
ETS
ROXHumanNervous system
Other cell lines
Claiborne 2013 Thesis2013Claiborne MS (2013) Exercice Training improves exercice capacity despite present muscle mitochondrial dysfunction in the TAZ shRNA mouse model of human barth syndrome. Master's Thesis 67pp.LEAK
OXPHOS
ETS
NIsolated mitochondriaMouseSkeletal muscle
Manko 2013 Acta Physiol (Oxf)2013Manko BO, Manko VV (2013) Mechanisms of respiration intensification of rat pancreatic acini upon carbachol-induced Ca2+ release. Acta Physiol (Oxf) 208:387-99.LEAK
OXPHOS
ETS
N
S
Permeabilized cellsRatIslet cell;pancreas;thymus
Clarke 2013 Int J Biochem Cell Biol2013Clarke KJ, Porter RK (2013) Uncoupling protein 1 dependent reactive oxygen species production by thymus mitochondria. Int J Biochem Cell Biol 45:81-9.LEAK
ETS
N
S
Gp
Isolated mitochondriaRatIslet cell;pancreas;thymus
Li 2013 Free Radic Biol Med2013Li H, Kumar Sharma L, Li Y, Hu P, Idowu A, Liu D, Lu J, Bai Y (2013) Comparative bioenergetic study of neuronal and muscle mitochondria during aging. Free Radic Biol Med 63:30-40.ETS
LEAK
CIV
N
S
Intact cellsMouseNervous system
Skeletal muscle
Karamercan 2013 Shock2013Karamercan MA, Weiss SL, Villarroel JP, Guan Y, Werlin E, Figueredo R, Becker LB, Sims C (2013) Can peripheral blood mononuclear cells be used as a proxy for mitochondrial dysfunction in vital organs during hemorrhagic shock and resuscitation? Shock 40:476-84.LEAK
ROUTINE
OXPHOS
ETS
N
S
CIV
Intact cells
Isolated mitochondria
RatHeart
Liver
Kidney
Blood cells
Lymphocyte
Gupte 2013 Endocrinology2013Gupte AA, Minze LJ, Reyes M, Ren Y, Wang X, Brunner G, Ghosn M, Cordero-Reyes AM, Ding K, Pratico D, Morrisett J, Shi ZZ, Hamilton DJ, Lyon CJ, Hsueh WA (2013) High fat feeding-induced hyperinsulinemia increases cardiac glucose uptake and mitochondrial function despite peripheral insulin resistance. Endocrinology 154:2650-62.LEAK
OXPHOS
ETS
N
S
ROX
Isolated mitochondriaMouseHeart
Hagl 2013 Pharmacol Res2013Hagl S, Kocher A, Schiborr C, Eckert SH, Ciobanu I, Birringer M, El-Askary H, Helal A, Khayyal MT, Frank J, Muller WE, Eckert GP (2013) Rice bran extract protects from mitochondrial dysfunction in guinea pig brains. Pharmacol Res 76C:17-27.LEAK
OXPHOS
ETS
N
S
CIV
NS
ROX
Isolated mitochondriaGuinea pigNervous system
Volejnikova 2013 FEMS Yeast Res2013Volejníková A, Hlousková J, Sigler K, Pichová A (2013) Vital mitochondrial functions show profound changes during yeast culture ageing. FEMS Yeast Res 13:7-15.ROUTINE
ETS
Intact cells
Isolated mitochondria
Saccharomyces cerevisiae
Fungi
Hall 2013 Oncotarget2013Hall A, Meyle KD, Lange MK, Klima M, Sanderhoff M, Dahl C, Abildgaard C, Thorup K, Moghimi SM, Jensen PB, Bartek J, Guldberg P, Christensen C (2013) Dysfunctional oxidative phosphorylation makes malignant melanoma cells addicted to glycolysis driven by the (V600E)BRAF oncogene. Oncotarget 4:584-99.LEAK
OXPHOS
ETS
N
ROX
HumanOther cell lines
Aidt 2013 PLoS Curr2013Aidt FH, Nielsen SM, Kanters J, Pesta D, Nielsen TT, Nørremølle A, Hasholt L, Christiansen M, Hagen CM (2013) Dysfunctional mitochondrial respiration in the striatum of the Huntington's disease transgenic R6/2 mouse model. PLoS Curr 5. pii:ecurrents.hd.d8917b4862929772c5a2f2a34ef1c201.LEAK
OXPHOS
ETS
N
S
CIV
NS
ROX
HomogenateMouseNervous system
Constant-Urban 2013 Bioorg Med Chem Lett2013Constant-Urban C, Charif M, Goffin E, Van Heugen JC, Elmoualij B, Chiap P, Mouithys-Mickalad A, Serteyn D, Lebrun P, Pirotte B, De Tullio P (2013) Triphenylphosphonium salts of 1,2,4-benzothiadiazine 1,1-dioxides related to diazoxide targeting mitochondrial ATP-sensitive potassium channels. Bioorg Med Chem Lett 23:5878-81.LEAK
ROUTINE
ETS
RatOther cell lines
Weber 2013 Thesis East Carolina University2013Weber T (2013) The effect of contractile activity and substrate challenges on metabolic flexibility in human primary myotubes. Thesis East Carolina University - USA:105 pp.LEAK
OXPHOS
ETS
N
S
NS
Permeabilized cellsHumanSkeletal muscle
Other cell lines
Viall 2013 J Autoimmun2013Viall CA, Chen Q, Liu B, Hickey A, Snowise S, Salmon JE, Stone PR, Chamley LW (2013) Antiphospholipid antibodies internalised by human syncytiotrophoblast cause aberrant cell death and the release of necrotic trophoblast debris. J Autoimmun 47:45-57.LEAK
OXPHOS
ETS
N
S
HumanGenital
Sjoevall 2013 Mitochondrion2013Sjövall F, Ehinger JK, Marelsson SE, Morota S, Asander Frostner E, Uchino H, Lundgren J, Arnbjörnsson E, Hansson Magnus J, Fellman V, Elmér E (2013) Mitochondrial respiration in human viable platelets - methodology and influence of gender, age and storage. Mitochondrion 13:7-14.LEAK
ROUTINE
OXPHOS
ETS
N
ROX
Intact cells
Permeabilized cells
HumanBlood cells
Platelet
Jacobs 2013 Exp Physiol2013Jacobs R, Boushel RC, Wright-Paradis C, Calbet JA, Robach P, Gnaiger E, Lundby C (2013) Mitochondrial function in human skeletal muscle following high altitude exposure. Exp Physiol 98:245-55.LEAK
OXPHOS
ETS
F
N
S
NS
Permeabilized tissueHumanSkeletal muscle
Vijgen 2013 J Clin Endocrinol Metab2013Vijgen GH, Sparks LM, Bouvy ND, Schaart G, Hoeks J, van Marken Lichtenbelt WD, Schrauwen P (2013) Increased oxygen consumption in human adipose tissue from the "brown adipose tissue" region. J Clin Endocrinol Metab 98:E1230-4.ETS
LEAK
ROUTINE
Permeabilized tissueHumanFat
Chacko 2013 Lab Invest2013Chacko BK, Kramer PA, Ravi S, Johnson MS, Hardy RW, Ballinger SW, Darley-Usmar VM (2013) Methods for defining distinct bioenergetic profiles in platelets, lymphocytes, monocytes, and neutrophils, and the oxidative burst from human blood. Lab Invest 93:690-700.LEAK
ROUTINE
ETS
ROXIntact cellsHumanBlood cells
Other cell lines
Lymphocyte
Platelet
Wohlwend 2013 Thesis2013Wohlwend M (2013) Mitochondrial function in health and disease - high-resolution respirometry in rats inbred for high vs. low running capacity. Thesis Norwegian University of Science and Technology - Trondheim: 44pp.LEAK
OXPHOS
ETS
F
N
S
NS
Permeabilized tissueRatHeart
Skeletal muscle
Pak 2013 Am J Respir Cell Mol Biol2013Pak O, Sommer N, Hoeres T, Bakr A, Waisbrod S, Sydykov A, Haag D, Esfandiary A, Kojonazarov B, Veit F, Fuchs B, Weisel FC, Hecker M, Schermuly RT, Grimminger F, Ghofrani HA, Seeger W, Weissmann N (2013) Mitochondrial hyperpolarization in pulmonary vascular remodeling - UCP2 deficiency as disease model. Am J Respir Cell Mol Biol 49:358-67.LEAK
ROUTINE
ETS
N
S
Intact cellsHuman
Rat
Lung;gill
Bhattacharyya 2013 PLoS One2013Bhattacharyya S, Saha S, Giri K, Lanza IR, Nair KS, Jennings NB, Rodriguez-Aguayo C, Lopez-Berestein G, Basal E, Weaver AL, Visscher DW, Cliby W, Sood AK, Bhattacharya R, Mukherjee P (2013) Cystathionine Beta-Synthase (CBS) contributes to advanced ovarian cancer progression and drug resistance. PLoS One 8:e79167.ROUTINE
ETS
Intact cellsHumanGenital
Other cell lines
Yuzefovych 2013 Endocrinology2013Yuzefovych LV, Schuler AM, Chen J, Alvarez DF, Eide L, Ledoux SP, Wilson GL, Rachek LI (2013) Alteration of mitochondrial function and insulin sensitivity in primary mouse skeletal muscle cells isolated from transgenic and knockout mice: role of OGG1. Endocrinology 154:2640-9.LEAK
ETS
NPermeabilized tissueMouseSkeletal muscle
Hughey 2013 Cardiovasc Diabetol2013Hughey CC, Ma L, James FD, Bracy DP, Wang Z, Wasserman DH, Rottman JN, Hittel DS, Shearer J (2013) Mesenchymal stem cell transplantation for the infarcted heart: therapeutic potential for insulin resistance beyond the heart. Cardiovasc Diabetol 12:128.OXPHOS
ETS
N
NS
Permeabilized tissueMouseHeart
Chu 2013 PLoS One2013Chu MJ, Phillips AR, Hosking AW, Macdonald JR, Bartlett AS, Hickey AJ (2013) Hepatic mitochondrial function analysis using needle liver biopsy samples. PLoS One 8:e79097.LEAK
OXPHOS
ETS
N
ROX
Permeabilized tissueHuman
Rat
Liver
Kenwood 2013 Mol Metab2013Kenwood BM, Weaver JL, Bajwa A, Poon IK, Byrne FL, Murrow BA, Calderone JA, Huang L, Divakaruni AS, Tomsig JL, Okabe K, Lo RH, Cameron Coleman G, Columbus L, Yan Z, Saucerman JJ, Smith JS, Holmes JW, Lynch KR, Ravichandran KS, Uchiyama S, Santos WL, Rogers GW, Okusa MD, Bayliss DA, Hoehn KL (2013) Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane. Mol Metab 3:114-23.ROUTINE
ETS
Intact organism
Intact cells
Mouse
Hroudova 2013 Mitochondrion2013Hroudová J, Fišar Z, Kitzlerová E, Zvěřová M, Raboch J (2013) Mitochondrial respiration in blood platelets of depressive patients. Mitochondrion 13:795-800.LEAK
ROUTINE
OXPHOS
ETS
N
S
NS
ROX
Intact cells
Permeabilized cells
HumanBlood cells
Platelet
Muller 2013 Exp Neurol2013Muller AP, Haas CB, Camacho-Pereira J, Brochier AW, Gnoatto J, Zimmer ER, de Souza DO, Galina A, Portela LV (2013) Insulin prevents mitochondrial generation of H2O2 in rat brain. Exp Neurol 247:66-72.LEAK
OXPHOS
ETS
N
S
RatNervous system
Freitas-Correa 2013 Stem Cell Res2013Freitas-Correa L, Lourenco MV, Acquarone M, da Costa RF, Galina A, Rehen SK, Ferreira ST (2013) 2,4-Dinitrophenol induces neural differentiation of murine embryonic stem cells. Stem Cell Res 11:1407-16.ETSIntact cellsMouseStem cells
Dos Santos 2013 J Bioenerg Biomembr2013dos Santos RS, Peçanha FL, da-Silva WS (2013) Functional characterization of an uncoupling protein in goldfish white skeletal muscle. J Bioenerg Biomembr 45:243-51.LEAK
OXPHOS
ETS
SIsolated mitochondriaFishesSkeletal muscle
Van der Laans 2013 J Clin Invest2013van der Lans AA, Hoeks J, Brans B, Vijgen GH, Visser MG, Vosselman MJ, Hansen J, Jörgensen JA, Wu J, Mottaghy FM, Schrauwen P, van Marken Lichtenbelt WD (2013) Cold acclimation recruits human brown fat and increases nonshivering thermogenesis. J Clin Invest 123:3395-403.LEAK
OXPHOS
ETS
N
NS
Permeabilized tissue
Isolated mitochondria
HumanSkeletal muscle
Ghozlan 2013 Thesis University of Calgary - Canada2013Ghozlan M (2013) The effect of myostatin on glucose metabolism and insulin sensitivity. Thesis University of Calgary - Canada 104pp.LEAK
ROUTINE
ETS
Intact cellsMouseSkeletal muscle
Liver
Other cell lines
Schwarzkopf 2013 Pharmazie2013Schwarzkopf TM, Hagl S, Eckert GP, Klein J (2013) Neuroprotection by bilobalide in ischemia: improvement of mitochondrial function. Pharmazie 68:584-9.LEAK
OXPHOS
ETS
N
S
CIV
ROX
Isolated mitochondriaMouseNervous system
Gottfried 2013 PLoS One2013Gottfried E, Lang SA, Renner K, Bosserhoff A, Gronwald W, Rehli M, Einhell S, Gedig I, Singer K, Seilbeck A, Mackensen A, Grauer O, Hau P, Dettmer K, Andreesen R, Oefner PJ, Kreutz M (2013) New aspects of an old drug - Diclofenac targets MYC and glucose metabolism in tumor cells. PLoS One 8:e66987.LEAK
ROUTINE
ETS
Intact cellsHuman
Mouse
Endothelial;epithelial;mesothelial cell
Blood cells
Other cell lines
Lymphocyte
La Guardia 2013 Front Physiol2013La Guardia PG, Alberici LC, Ravagnani FG, Catharino RR, Vercesi AE (2013) Protection of rat skeletal muscle fibers by either L-carnitine or coenzyme Q10 against statins toxicity mediated by mitochondrial reactive oxygen generation. Front Physiol 4:103.ETS
LEAK
OXPHOS
CIV
N
S
Permeabilized tissueRatSkeletal muscle
Sjövall 2013 Thesis Lund University - Sweden2013Sjövall F (2013) Mitochondrial function in sepsis - temporal evolvement of respiratory capacity in human blood cells. Thesis Lund University - Sweden 83pp.LEAK
ROUTINE
OXPHOS
ETS
N
S
ROX
Intact cells
Permeabilized cells
HumanBlood cells
Platelet
Bresciani Martins de Andrade P 2013 J Bioenerg Biomembr2013Bresciani Martins de Andrade P, Glaser V, da Luz Scheffer D, de Paula Ferreira PM, Wannmacher CM, Farina M, de Oliveira PA, Prediger RD, Latini A (2013) Platelet oxygen consumption as a peripheral blood marker of brain energetics in a mouse model of severe neurotoxicity. J Bioenerg Biomembr 45:449-57.ROUTINE
ETS
MouseBlood cells
Platelet
Dickinson 2013 Thesis University of Warwick - Great Britain2013Dickinson A (2013) The role of mitochondrial DNA in tumorigenesis. Thesis University of Warwick - Great Britain 292pp.LEAK
ROUTINE
ETS
ROXIntact cellsHumanOther cell lines
Villarroel 2013 J Trauma Acute Care Surg2013Villarroel JP, Guan Y, Werlin E, Selak MA, Becker LB, Sims CA (2013) Hemorrhagic shock and resuscitation are associated with peripheral blood mononuclear cell mitochondrial dysfunction and immunosuppression. J Trauma Acute Care Surg 75:24-31.LEAK
ROUTINE
ETS
S
ROX
Intact cellsRatBlood cells
Lymphocyte
Dos Santos 2013 Bio Open2013Dos Santos RS, Galina A, Da-Silva WS (2013) Cold acclimation increases mitochondrial oxidative capacity without inducing mitochondrial uncoupling in goldfish white skeletal muscle. Bio Open 2:82-7.LEAK
OXPHOS
ETS
N
S
Permeabilized tissue
Isolated mitochondria
FishesSkeletal muscle
Zeh 2013 Thesis2013Zeh RM (2013) Neurological and molecular biological characterisation of the mutant mouse line Tom40. Thesis Technische Universität München 243pp.OXPHOS
ETS
N
S
ROX
Isolated mitochondriaRatHeart
Nervous system
Strobel 2013 PLoS One2013Strobel A, Graeve M, Poertner HO, Mark FC (2013) Mitochondrial acclimation capacities to ocean warming and acidification are limited in the antarctic nototheniid fish, Notothenia rossii and Lepidonotothen squamifrons. PLoS One 8:e68865.LEAK
OXPHOS
ETS
N
S
NS
ROX
Isolated mitochondriaFishesLiver
Pichaud 2013 J Bioenerg Biomembr2013Pichaud N, Ballard JWO, Tanguay RM, Blier PU (2013) Mitochondrial haplotype divergences affect specific temperature sensitivity of mitochondrial respiration. J Bioenerg Biomembr 45:25-35.LEAK
OXPHOS
ETS
N
NS
ROX
Permeabilized tissueHexapodsSkeletal muscle
Wredenberg 2013 PLoS Genet2013Wredenberg A, Lagouge M, Bratic A, Metodiev MD, Spåhr H, Mourier A, Freyer C, Ruzzenente B, Tain L, Grönke S, Baggio F, Kukat C, Kremmer E, Wibom R, Polosa PL, Habermann B, Partridge L, Park CB, Larsson NG (2013) MTERF3 regulates mitochondrial ribosome biogenesis in invertebrates and mammals. PLoS Genet 9:e1003178.LEAK
OXPHOS
ETS
N
S
Gp
NS
Permeabilized tissueDrosophila
Segalés 2013 Am J Physiol Endocrinol Metab2013Segalés J, Paz JC, Hernández-Alvarez MI, Sala D, Muñoz JP, Noguera E, Pich S, Palacín M, Enríquez JA, Zorzano A (2013) A form of mitofusin 2 (Mfn2) lacking the transmembrane domains and the COOH-terminal end stimulates metabolism in muscle and liver cells. Am J Physiol Endocrinol Metab 305:1208-21.LEAK
ROUTINE
OXPHOS
ETS
NIntact cells
Permeabilized tissue
MouseSkeletal muscle
Liver
Other cell lines
Costa 2013 Cell Death Dis2013Costa AC, Loh SH, Martins LM (2013) Drosophila Trap1 protects against mitochondrial dysfunction in a PINK1/parkin model of Parkinson's disease. Cell Death Dis 4:e467.OXPHOS
ETS
N
S
Permeabilized tissueDrosophila
Smith 2013 Thesis The University of Guelph - Canada2013Smith BK (2013) Investigations into the regulation of skeletal muscle mitochondrial metabolism. Thesis The University of Guelph - Canada 139pp.ETS
LEAK
OXPHOS
N
NS
ROX
Permeabilized tissueRatSkeletal muscle
Karlsson 2013 Int J Biochem Cell Biol2013Karlsson M, Hempel C, Sjövall F, Hansson Magnus J, Kurtzhals JA, Elmér E (2013) Brain mitochondrial function in a murine model of cerebral malaria and the therapeutic effects of rhEPO. Int J Biochem Cell Biol 45:151-5.LEAK
OXPHOS
ETS
HomogenateMouseNervous system
Alvarez-Fischer 2013 J Neurochem2013Alvarez-Fischer D, Noelker C, Grünewald A, Vulinović F, Guerreiro S, Fuchs J, Lu L, Lombès A, Hirsch EC, Oertel WH, Michel PP, Hartmann A (2013) Probenecid potentiates MPTP/MPP+ toxicity by interference with cellular energy metabolism. J Neurochem 127:782-92.LEAK
OXPHOS
ETS
N
ROX
Mouse
Schneeberger 2013 Cell2013Schneeberger M, Dietrich MO, Sebastián D, Imbernón M, Castaño C, Garcia A, Esteban Y, Gonzalez-Franquesa A, Rodríguez IC, Bortolozzi A, Garcia-Roves PM, Gomis R, Nogueiras R, Horvath TL, Zorzano A, Claret M (2013) Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance. Cell 155:172-87.LEAK
OXPHOS
ETS
N
NS
ROX
HomogenateMouseNervous system
De Castro IP 2013 Cell Death Dis2013de Castro IP, Costa AC, Celardo I, Tufi R, Dinsdale D, Loh SH, Martins LM (2013) Drosophila ref(2)P is required for the parkin-mediated suppression of mitochondrial dysfunction in pink1 mutants. Cell Death Dis 24:e873.LEAK
OXPHOS
ETS
N
S
HomogenateDrosophila
Rojahn 2013 Thesis Norwegian University of Life Sciences - Ås2013Rojahn L (2013) Effects of micronutrients on survival and mitochondrial viability in honey bees (Apis mellifera). Thesis Norwegian University of Life Sciences - Ås: 41 pp.OXPHOS
ETS
N
S
ROX
Permeabilized tissueHexapodsSkeletal muscle
Iftikar 2013 PLoS One2013Iftikar FI, Hickey AJ (2013) Do mitochondria limit hot fish hearts? Understanding the role of mitochondrial function with heat stress in Notolabrus celidotus. PLoS One 8:e64120.LEAK
OXPHOS
ETS
N
CIV
NS
ROX
Permeabilized tissueFishesHeart
Martinez 2013 Marine Biol2013Martinez E, Menze MA, Torres JJ (2013) Mitochondrial energetics of benthic and pelagic Antarctic teleosts. Marine Biol 160:2813-23.LEAK
OXPHOS
ETS
N
S
NS
HomogenateFishesLiver
Perales Villarroel 2013 J Surg Res2013Perales Villarroel JP, Figueredo R, Guan Y, Tomaiuolo M, Karamercan MA, Welsh J, Selak MA, Becker LB, Sims C (2013) Increased platelet storage time is associated with mitochondrial dysfunction and impaired platelet function. J Surg Res 184:422-9.ROUTINE
OXPHOS
ETS
N
S
NS
ROX
Permeabilized cellsHumanBlood cells
Platelet
Trumbeckaite 2013 Mitochondrion2013Trumbeckaite S, Gizatullina Z, Arandarcikaite O, Röhnert P, Vielhaber S, Malesevic M, Fischer G, Seppet E, Striggow F, Gellerich FN (2013) Oxygen glucose deprivation causes mitochondrial dysfunction in cultivated rat hippocampal slices: Protective effects of CsA, its immunosuppressive congener [D-Ser](8)CsA, the novel non-immunosuppressive cyclosporin derivative Cs9, and the NMDA receptor antagonist MK 801. Mitochondrion 13:539–47.LEAK
OXPHOS
ETS
N
S
HomogenateRatNervous system
Henriques 2013 Thesis Universidade de Coimbra - Portugal2013Henriques TAF (2013) High-resolution respirometry for metabolic profiling of acute rat hippocampal slices. Thesis Universidade de Coimbra - Portugal 38pp.LEAK
ROUTINE
ETS
N
S
ROX
Intact cellsRatNervous system
Hagenbuchner 2013 Oncogene2013Hagenbuchner J, Kuznetsov AV, Obexer P, Ausserlechner MJ (2013) BIRC5/Survivin enhances aerobic glycolysis and drug resistance by altered regulation of the mitochondrial fusion/fission machinery. Oncogene 32:4748-57.OXPHOS
ETS
N
S
CIV
Intact cells
Permeabilized cells
HumanOther cell lines
Stride 2013 Eur J Heart Fail2013Stride N, Larsen S, Hey-Mogensen M, Sander K, Lund JT, Gustafsson F, Kober L, Dela F (2013) Decreased mitochondrial oxidative phosphorylation capacity in the human heart with left ventricular systolic dysfunction. Eur J Heart Fail 15:150-7.OXPHOS
ETS
N
S
CIV
NS
Permeabilized tissueHumanHeart
Mayeur 2013 PhD Thesis2013Mayeur S (2013) Retard de croissance intra-utérin et vulnérabilité au syndrome métabolique: recherche de marqueurs placentaires dans un modèle de dénutrition maternelle prénatale et chez l'Homme. PhD Thesis 1-225.LEAK
OXPHOS
ETS
N
S
CIV
NS
ROX
Isolated mitochondriaRatGenital
Thompson 2013 J Surg Res2013Thompson JR, Swanson SA, Casale GP, Johanning JM, Papoutsi E, Koutakis P, Miserlis D, Zhu Z, Pipinos II (2013) Gastrocnemius mitochondrial respiration: are there any differences between men and women? J Surg Res 185:206-11.OXPHOS
ETS
N
S
CIV
Permeabilized tissueHumanSkeletal muscle
... further results


Publications in the MiPMap

Abstracts: ETS

Sort in ascending/descending order by a click on one of the small symbols in squares below.
 YearReferenceCouplingPathwayPreparationOrganismTissue;cell
Sobotka 2016 Abstract IOC1162016Sobotka O, Kucera O, Stankova P, Endlicher R, Nozickova K, Banni A, Cervinkova Z (2016) Mitochondrial respiration in fatty liver. Mitochondr Physiol Network 21.11ETS
LEAK
OXPHOS
CIV
F
Gp
N
NS
Other combinations
ROX
S
Isolated mitochondriaRatLiver
Krumschnabel 2016b Abstract MitoFit Science Camp 20162016O2k-MultiSensor: Mitochondrial respiration media for HRR and simultaneous O2k-Fluorometry.LEAK
OXPHOS
ETS
N
S
NS
ROX
HumanKidney
HEK
Sumbalova 2016a Abstract MitoFit Science Camp 20162016Optimizing strategies on the malate concentration in SUIT protocols.OXPHOS
ETS
N
S
NS
RatNervous system
Krajcova 2016 Abstract MitoFit Science Camp 20162016Mitochondrial pathogenesis of propofol infusion syndrome in an in vitro model of human skeletal muscle.LEAK
ETS
FHomogenateHumanSkeletal muscle
Volani 2016 Abstract Mito Xmas Meeting Innsbruck2016Effects of systemic iron perturbations on mitochondrial activity and on cellular metabolism in vivo.LEAK
ROUTINE
OXPHOS
ETS
N
S
HomogenateMouseLiver
Soendergaard 2016 Abstract IOC1092016Soendergaard SD (2016) Acute exposure of human muscle fibers to EPO or Actovegin has a marked effect on the mitochondrial respiratory capacity. Mitochondr Physiol Network 21.01.OXPHOS
ETS
N
NS
Permeabilized tissueHumanSkeletal muscle
Cecatto 2016 Abstract IOC1162016Cecatto C, Silva JC, Wajner A, Godoy KS, Ribeiro, RT, Amaral AU, Wajner M (2016) cis-4-Decenoic and decanoic acids impair mitochondrial energy, redox and Ca2+ homeostasis and induce mitochondrial permeability transition pore opening in rat brain and liver. Mitochondr Physiol Network 21.11LEAK
OXPHOS
ETS
F
N
CIV
Other combinations
Permeabilized tissue
Isolated mitochondria
RatNervous system
Liver
Bezuidenhout 2016b Abstract MitoFit Science Camp 20162016Analysis and comparison of mitochondrial function using cooling plate or ice during mechanical separation of mouse skeletal muscle fibers.LEAK
OXPHOS
ETS
N
S
ROX
Permeabilized tissueMouseSkeletal muscle
Laner 2016 Abstract MitoFit Science Camp 20162016OXPHOS and ETS capacity in permeabilized fibres of canine superathletes. Analysis of HRR data presenting unexpected challenges.LEAK
OXPHOS
ETS
F
N
S
NS
ROX
Permeabilized tissueDogSkeletal muscle
Calzia 2016 Abstract MitoFit Science Camp 20162016Mitochondrial respiration shows tissue- and strain-specific aging in short- and long-lived N. furzeri strains.LEAK
OXPHOS
ETS
NSFishesHeart
Skeletal muscle
Nervous system
Liver
Gnaiger 2016 Abstract UMDF20162016Schöpf B, Schäfer G, Weber A, Talasz H, Eder IE, Klocker H, Gnaiger E (2016) Oxidative phosphorylation and mitochondrial function differ between human prostate tissue and cultured cells.LEAK
OXPHOS
ETS
F
N
NS
Permeabilized cells
Permeabilized tissue
HumanEndothelial;epithelial;mesothelial cell
Genital
Other cell lines
Fibroblast
Sumbalova 2016 Abstract Mito Xmas Meeting Innsbruck2016Methods for evaluation of mitochondrial membrane potential with multi-sensor high-resolution respirometry: potentiometry vs fluorometry.LEAK
OXPHOS
ETS
F
N
S
NS
ROX
MouseNervous system
Lamberti 2016 Abstract MitoFit Science Camp 20162016Development of a reference sample for HRR.LEAK
ROUTINE
OXPHOS
ETS
F
N
S
Gp
CIV
NS
Other combinations
ROX
HumanKidney
HEK
Louw 2016 Abstract FASEB J2016Exercise limits loss of respiratory function seen with doxorubicin treatment without affecting muscle function.ETSN
S
Permeabilized tissueMouseSkeletal muscle
Burtscher J 2016 Abstract MitoFit Science Camp 20162016Oxidative phosphorylation in the healthy and epileptic mouse brain.OXPHOS
ETS
N
S
HomogenateMouseNervous system
Chicco 2016b Abstract MitoFit Science Camp 20162016OXPHOS coupling efficiency of permeabilized muscle fibers predicts metabolic efficiency of subjects exercising at 5260 m.LEAK
OXPHOS
ETS
F
N
Permeabilized tissueHumanSkeletal muscle
Laner 2016 Abstract Mito Xmas Meeting Innsbruck2016OXPHOS and ETS capacity in permeabilized fibres of canine superathletes.LEAK
OXPHOS
ETS
F
N
S
NS
ROX
Permeabilized tissueDogSkeletal muscle
Murphy 2016 Abstract FASEB J2016Metformin limits loss of mitochondrial respiration seen with doxorubicin treatment without affecting muscle function.ETSN
S
Permeabilized tissueMouseSkeletal muscle
Hoppel 2016c Abstract MitoFit Science Camp 20162016Mitochondrial respiration in permeabilized skin fibroblasts.ETS
OXPHOS
CIV
N
NS
ROX
S
Permeabilized cellsHumanEndothelial;epithelial;mesothelial cell
Fibroblast
Krumschnabel 2016a Abstract MitoFit Science Camp 20162016O2k-Protocols: Mitochondrial preparations for HRR.LEAK
OXPHOS
ETS
N
S
NS
ROX
Permeabilized tissue
Homogenate
Isolated mitochondria
MouseHeart
Osiki 2016 Abstract MitoFit Science Camp 20162016Suitability of octanoylcarnitine & malate for assessment of beta oxidation capacity by respirometry in aconitase-inhibited samples.OXPHOS
ETS
F
N
Other combinations
RatSkeletal muscle
Doerrier 2016b Abstract Mito Xmas Meeting Innsbruck2016Searching for specific targets of ischemic damage of cardiac mitochondria using O2k-Fluorometry.LEAK
OXPHOS
ETS
F
N
S
Gp
CIV
ROX
Isolated mitochondriaMouseHeart
Sumbalova 2016b Abstract MitoFit Science Camp 20162016Human blood cells: isolation and HRR.LEAK
ROUTINE
OXPHOS
ETS
F
N
S
Gp
CIV
NS
Other combinations
ROX
Intact cells
Permeabilized cells
HumanBlood cells
Lymphocyte
Platelet
Volani 2016 Abstract MitoFit Science Camp 20162016Effects of iron imbalances on mitochondrial activity in mouse liver homogenate and permabilized rat PBMCs.LEAK
OXPHOS
ETS
N
S
HomogenateMouse
Rat
Liver
Blood cells
Lymphocyte
Doerrier 2016 Abstract MitoFit Science Camp 20162016Development of a SUIT reference protocol for OXPHOS analysis by high-resolution respirometry.LEAK
ROUTINE
OXPHOS
ETS
F
N
S
Gp
CIV
NS
ROX
Permeabilized cells
Permeabilized tissue
Homogenate
Isolated mitochondria
Human
Mouse
Heart
Blood cells
HEK
Platelet
Madlala 2016 Abstract MitoFit Science Camp 20162016Fructose-induced defects in selected mitochondrial enzymes is detected by respirometry using glutamate&malate but not pyruvate&malate substrates.LEAK
OXPHOS
ETS
NPermeabilized cellsHumanLiver
Schoepf 2016 Abstract Mito Xmas Meeting Innsbruck2016Mitochondrial function in primary prostate cancer.ETS
LEAK
OXPHOS
N
Other combinations
S
Permeabilized tissueHuman
Chou 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Chou 2015 Fatty Acid Oxidation O2k-Network Discussion ForumOXPHOS
ETS
F
N
S
NS
ROX
Permeabilized cells
Permeabilized tissue
Blood cells
Lymphocyte
Platelet
Ali 2015 Abstract MiPschool Cape Town 20152015Early gender-related dimorphism in heart and brain mitochondria function and ROS dynamics.LEAK
OXPHOS
ETS
MouseHeart
Nervous system
Sleiman 2015 Abstract MiP20152015Mitochondrial respiration in sequential biospies from skeletal muscles during hemorrhagic shock and over the course of 48h of reperfusion in pigs.LEAK
OXPHOS
ETS
N
S
HomogenatePigSkeletal muscle
Smenes 2015 Abstract IOC1002015Smenes BT, Baekkerud FH, Hassel E, Wohlwend M, Slagsvold KH, Rognmo O, Wahba A (2015) Mitochondrial function in patients exercising prior to coronary surgery – A single blinded randomized controlled trial. Mitochondr Physiol Network 20.01.LEAK
ROUTINE
ETS
N
S
HumanSkeletal muscle
Hoppel 2015 Abstract MiP20152015Effects of ultramarathon performance on mitochondrial respiration in human platelets.ROUTINE
OXPHOS
ETS
N
S
NS
Permeabilized cellsHumanBlood cells
Platelet
Ljubkovic 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Ljubkovic 2015 Fatty Acid Oxidation O2k-Network Discussion ForumOXPHOS
ETS
F
N
NS
Permeabilized tissueHumanHeart
Laner 2015 Abstract MiPschool Greenville 20152015Comparative mitochondrial physiology: OXPHOS and ETS capacity in permeabilized fibres of canine superathletes.OXPHOS
ETS
F
N
S
NS
Permeabilized tissueDogSkeletal muscle
Komelina 2015 Abstract MiP20152015Artificial hypothermia of rats, as opposed to natural hibernation of ground squirrels Spermophilus undulatus, is not accompanied by inhibition of mitochondrial respiration in liver.ETSRat
Other mammals
Liver
Nardin 2015 Abstract MiPschool London 20152015Parkin translocation is triggered by its dephosporylation by calcineurin.ETS
Weidgang 2015 Abstract MiP20152015Mitochondrial respiration in homogenized biopsies from kidney, liver, heart and diaphragm from mice after blunt thoracic trauma and hemorrhagic shock. Effects of a novel hydrogen sulfide donor AP39.LEAK
OXPHOS
ETS
N
S
HomogenateMouseHeart
Skeletal muscle
Liver
Kidney
Gnaiger 2015 Abstract MiPschool Cape Town 20152015The functional design of the electron transfer system: substrate control of mitochondrial respiration.LEAK
ROUTINE
OXPHOS
ETS
N
S
NS
Permeabilized cells
Permeabilized tissue
Homogenate
Isolated mitochondria
Gnaiger 2015 Abstract MiP20152015Mitochondrial function of cyropreserved HEK 293T cells: development of a reference sample for high-resolution respirometry.LEAK
ROUTINE
OXPHOS
ETS
N
S
NS
Intact cells
Permeabilized cells
HumanHEK
Ojuka 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Ojuka 2015 Fatty Acid Oxidation O2k-Network Discussion ForumOXPHOS
ETS
FPermeabilized tissue
Rutkai 2015 Abstract MiPschool Greenville 20152015Sex-differences in mitochondrial respiration is mediated by nitric oxide in rat cerebral arteries.LEAK
ROUTINE
ETS
RatEndothelial;epithelial;mesothelial cell
Volani 2015 Abstract IOC1062015Volani C, Haschka D, Demetz E, Doerrier C, Gnaiger E, Weiss G (2015) Determination of mitochondrial respiration in peripheral blood mononuclear cells. Mitochondr Physiol Network 20.10.ROUTINE
OXPHOS
ETS
N
S
Intact cells
Homogenate
Human
Mouse
Heart
Liver
Blood cells
Lymphocyte
Mussulini 2015 Abstract MiPschool London2015Changes of brain substrates preference and metabolism during seizure induced by pentylenetetrazole in adult zebrafish.ETS
ROUTINE
N
S
Intact organZebrafishNervous system
Devaux 2015 Abstract MiP20152015Mitochondrial complexes I and II behave differently in two anoxia-tolerant species: adaptive mitochondrial plasticity may be related to the ability to undergo metabolic depression.ETS
LEAK
OXPHOS
N
S
HomogenateFishesNervous system
Laner 2015 Abstract MiPschool Cape Town 20152015The OROBOROS Oxygraph-2k for high-resolution respirometry and O2k-Fluorometry: a new quality in OXPHOS analysis.LEAK
ROUTINE
OXPHOS
ETS
N
S
NS
Intact cells
Isolated mitochondria
Mouse
Saccharomyces cerevisiae
Heart
Karabatsiakis 2015 Abstract MiP20152015Mitochondrial respiration of peripheral blood mononuclear cells in patients with borderline personality disorder.LEAK
ROUTINE
OXPHOS
ETS
ROXHumanBlood cells
Smith 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Smith 2015 Fatty Acid Oxidation O2k-Network Discussion ForumOXPHOS
ETS
FPermeabilized tissue
Morris 2015 Abstract MiPschool Greenville 20152015Intrinsic high aerobic capacity is associated with protection of mitochondrial respiratory capacity and decreased inflammation following chronic high-fat/high-cholesterol diet challenge.OXPHOS
ETS
NRatLiver
Lindquist 2015 Abstract IOC1062015Alteraas EK, Lindquist C, Berge RK, Bjorndal B (2015) OXPHOS capacity in mouse liver altered by modified fatty acids that inhibit or stimulate beta-oxidation. Mitochondr Physiol Network 20.10.OXPHOS
ETS
HomogenateMouseLiver
Dyrstad 2015 Abstract MiPschool London 20152015Activation of epithelial to mesenchymal transition (EMT) regulates stemness and metabolic reprogramming in mammary epithelial cells.LEAK
ROUTINE
ETS
N
ROX
HumanEndothelial;epithelial;mesothelial cell
Other cell lines
Renshaw 2015 Abstract MiP20152015Mitochondrial responses to thermal stress: is the ability to withstand anoxia-induced stress associated with cross-tolerance to thermal stress?LEAK
OXPHOS
ETS
N
S
HomogenateFishesNervous system
Gnaiger 2015 Abstract MiPschool Cape Town 2015 II2015On coupling control of mitochondrial respiration. What is wrong with the RCR?LEAK
ROUTINE
OXPHOS
ETS
N
S
ROX
Ali 2015 Abstract MiP20152015Mitochondrial function and ROS homeostasis in young mouse heart and brain: the sex factor!LEAK
OXPHOS
ETS
HomogenateMouseHeart
Nervous system
Schauer 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Schauer 2015 Fatty Acid Oxidation O2k-Network Discussion ForumOXPHOS
ETS
FPermeabilized tissue
Blecha 2015 Abstract MiP20152015Modulation of mitochondrial electron transport chain activity differentially regulates cell death in proliferating and quiescent cells.LEAK
ETS
ROX
Cannon 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Cannon 2015 Fatty Acid Oxidation O2k-Network Discussion ForumLEAK
OXPHOS
ETS
F
N
S
NS
ROX
Permeabilized tissueHuman
Mouse
Skeletal muscle
Hill 2015 Abstract MiPschool London 20152015A novel inhibitor of the mitochondrial permeability transition pore is beneficial in an experimental model of multiple sclerosis.OXPHOS
ETS
Isolated mitochondriaMouseLiver
Sumbalova 2015 Abstract MiP20152015High-resolution measurement of mitochondrial membrane potential and respiration – comparison of potentiometric and fluorometric methods.LEAK
OXPHOS
ETS
N
S
NS
Isolated mitochondriaMouseNervous system
Ciapaite 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Ciapaite 2015 Fatty Acid Oxidation O2k-Network Discussion ForumLEAK
OXPHOS
ETS
FPermeabilized tissueHuman
Rat
Skeletal muscle
Ojuka 2015 Abstract MiPschool Cape Town 20152015Use of malate or carnitine as co-substrates for assessment of fatty acid oxidation.LEAK
OXPHOS
ETS
Permeabilized cells
Permeabilized tissue
Isolated mitochondria
Rohlena 2015 Abstract MiP20152015Ubiquinone-binding site mutagenesis reveals the role of mitochondrial complex II in cell death initiation.ROUTINE
OXPHOS
ETS
S
ROX
Permeabilized cells
Isolated mitochondria
HumanOther cell lines
Van Dyk 2015 Abstract MiPschool Cape Town 20152015Optimization of selected cell lines for use on the Seahorse extracellular flux analyzer.LEAK
ROUTINE
ETS
N
ROX
Isolated mitochondriaHumanOther cell lines
Fibroblast
Calzia 2015 Abstract MiP20152015Mitochondrial respiration in homogenized small tissue biopsies from the M. Vastus lateralis of patients with Huntington's Disease before and after cycling exercise.LEAK
OXPHOS
ETS
N
S
ROX
HumanSkeletal muscle
Wuest 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Wuest 2015 Fatty Acid Oxidation O2k-Network Discussion ForumOXPHOS
ETS
F
N
S
NS
ROX
Permeabilized tissueRatHeart
Sheldon 2015 Abstract MiPschool Greenville 20152015eNOS is required to preserve hepatic mitochondrial function in western diet-induced nonalcoholic fatty liver disease.LEAK
OXPHOS
ETS
N
NS
MouseLiver
Laner 2015 Abstract MiP20152015Comparative mitochondrial physiology: OXPHOS and ETS capacity in permeabilized fibres of canine superathletes.LEAK
OXPHOS
ETS
F
N
S
NS
ROX
Permeabilized tissueDogSkeletal muscle
Porter 2014 Abstract IOC952014Porter C (2014) The impact of resistance exercise training on skeletal muscle mitochondrial respiration in healthy young adults. Mitochondr Physiol Network 19.10LEAK
OXPHOS
ETS
Permeabilized tissueHumanSkeletal muscle
Burtscher 2014 Abstract MiP20142014Region-specific differences in Complex I- and Complex II-linked respiration in the mouse brain.OXPHOS
ETS
N
S
CIV
NS
Permeabilized tissueMouseNervous system
Felser 2014 Abstract MiP20142014Assessing mitochondrial dysfunction in fibroblast cells – a comparison between O2k and multiwell respirometry.ROUTINE
ETS
ROXIntact cellsHumanEndothelial;epithelial;mesothelial cell
HeLa
Fibroblast
Laner 2014 Abstract MiP20142014Cytochrome c flux control factor as a quality criterion in respiratory OXPHOS analysis in canine permeabilized fibres.LEAK
ROUTINE
OXPHOS
ETS
N
NS
Permeabilized tissueDogSkeletal muscle
Nagy 2014 Abstract MiP20142014Investigation of the energy metabolism of microglial cells.ETS
ROUTINE
Intact cellsHumanNervous system
Kluckova 2014 Abstract MiP20142014Proximal ubiquinone binding site in mitochondrial respiratory Complex II is a target for vitamin E analog MitoVES, an experimental anti-cancer agent. Mitochondr Physiol Network 19.13.OXPHOS
ETS
SOther cell lines
Karabatsiakis 2014 Abstract IOC962014Karabatsiakis A (2014) Consequences of depression on respiratory activity in peripheral blood mononuclear cells. Mitochondr Physiol Network 19.11.LEAK
ROUTINE
ETS
Intact cellsHumanBlood cells
Lymphocyte
Schoepf 2014 Abstract MiP20142014OXPHOS analysis in small prostate biopsies.LEAK
OXPHOS
ETS
N
S
CIV
NS
Permeabilized tissueHumanGenital
Paes 2014 Abstract IOC 2014-04 Schroecken2014Paes MC, Saraiva FMS, Nogueira NP, Laranja GAT, Coelho MGP, Oliveira MF (2014) Heme increases mitochondrial membrane potential and ROS production in Trypanosoma cruzi epimastigotes. Mitochondr Physiol Network 19.02.LEAK
OXPHOS
ETS
S
Other combinations
Permeabilized cells
Oxidase;biochemical oxidation
Protists
Komlodi 2014 Abstract MiP20142014Methylenblue, an enhancer of mitochondrial substrate-level phosphorylation.OXPHOS
ETS
N
S
Isolated mitochondriaGuinea pigNervous system
Doerrier 2014 Abstract SECF2014Evaluation of melatonin treatment in mitochondria of permeabilized myocardial fibers from septic mice.LEAK
OXPHOS
ETS
N
S
NS
ROX
Permeabilized tissue
Isolated mitochondria
MouseHeart
Sumbalova 2014 Abstract MiP20142014Optimization of malate concentration for high-resolution respirometry: mitochondria from rat liver and brain.OXPHOS
ETS
F
N
S
NS
Isolated mitochondriaRatNervous system
Liver
Mendonca 2014 Abstract IOC 2014-04 Schroecken2014Mendonca AP, Rodrigues MF, Amoedo ND, Oliveira MF (2014) Effects of iron on mitochondrial physiology of central nervous system cell lines. Mitochondr Physiol Network 19.02.LEAK
OXPHOS
ETS
Nervous system
Other cell lines
Neuroblastoma
Krumschnabel 2014 Abstract MiP20142014Simultaneous high-resolution measurement of mitochondrial respiration and hydrogen peroxide production.LEAK
OXPHOS
ETS
N
S
NS
Homogenate
Isolated mitochondria
MouseNervous system
Dohlmann 2014 Abstract MiP20142014Mitochondrial adaptations to high-intensity training in young and elderly men and women.OXPHOS
ETS
Permeabilized cellsHumanSkeletal muscle
HeLa
Fibroblast
Volodina 2014 Abstract MiP20142014Multipotent stromal cells injection improves rat liver regeneration through activation of mitochondrial functions after subtotal hepatectomy.LEAK
OXPHOS
ETS
N
NS
Isolated mitochondriaRatLiver
Alberici 2014 Abstract MiP20142014Effects of long-chain acyl-CoA synthetase 6 knockdown in primary skeletal muscle cells metabolism.LEAK
ROUTINE
ETS
Intact cellsRatSkeletal muscle
El-Bacha 2014 Abstract MiP20142014Cytotoxicity of grape pomace extract (Vitis vinifera L.) from Brazilian wine industry in human hepatocarcinoma HepG2 cells.LEAK
ROUTINE
ETS
Intact cellsHumanLiver
Dzialowski 2013 Abstract MiP20132013Dzialowski EM, Ream S, Duquaine A, Sirsat TS, Goy Sirsat SK (2013) Mitochondrial function and the development of endothermy in the precocial Pekin duck (Anas pekin). Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ETS
F
N
S
NS
Intact organism
Permeabilized tissue
BirdsSkeletal muscle
Cavalcanti de Albuquerque 2013 Abstract MiP20132013Cavalcanti de Albuquerque JP, Salvador IC, Martins EG, Jardim-Messeder D; Werneck de Castro JPS; Carvalho DP; Galina A (2013) Skeletal muscle mitochondrial function in ovariectomized rats: A time course study and the role of estrogen replacement. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ETS
F
N
S
Gp
NS
ROX
Intact organism
Permeabilized tissue
RatSkeletal muscle
Hendricks 2013 Abstract MiP20132013Hendricks E, Nathan BP, Menze MA (2013) Bioenergetics of permeabilized and intact nerve cell terminals from ApoE deficient and wild type mice. Mitochondr Physiol Network 18.08.LEAK
ROUTINE
OXPHOS
ETS
N
S
NS
Intact cells
Permeabilized cells
Isolated mitochondria
MouseNervous system
Salin 2013 Abstract MiP20132013Salin K, Luquet E, Rey B, Roussel D, Voituron Y (2013) Mitochondrial functioning, a proximate mechanism underlying the pace-of- life? Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ETS
S
CIV
Isolated mitochondria
Enzyme
Oxidase;biochemical oxidation
Other mammals
Amphibians
Liver
Laner 2013 ASMRM2013Laner V, Gradl P, Eigentler A, Fontana-Ayoub M, Fasching M, Gnaiger E (2013) The OROBOROS Oxygraph-2k for high-resolution respirometry and O2k-Fluorometry: a new quality in OXPHOS analysis. ASMRM2013.LEAK
OXPHOS
ETS
N
S
NS
HomogenateMouseHeart
Christen 2013 Abstract MiP20132013Christen F, Desrosiers V, Blier PU (2013) Thermal sensitivity of mitochondria from arctic charr heart: Mitochondrial respiration and ROS production. Mitochondr Physiol Network 18.08.ETS
OXPHOS
CIV
N
NS
ROX
S
Isolated mitochondriaFishes
Other mammals
Heart
Hickey 2013 Abstract MiP20132013Hickey AJ, Iftikar FI, MacDonald J, Baker D (2013) Mitochondria in a changing climate? The role of mitochondrial in hyperthermic heart failure in different fish species. Mitochondr Physiol Network 18.08.ETS
LEAK
OXPHOS
ROUTINE
CIV
N
NS
S
Permeabilized tissueFishes
Other mammals
Heart
Galina 2013 Abstract MiP20132013Galina A, Messeder DJM, Camacho-Pereira J, Pereira da Silva AP, Rodrigues-Ferreira C (2013) Effects of antitumor alkylating agent 3-bromopyruvate on energy transducing pathways in hepatoma HepG2, liver mitochondria and SERCA: Is there any role for mitochondrial hexokinase activity? Mitochondr Physiol Network 18.08.LEAK
ROUTINE
OXPHOS
ETS
N
S
Intact cells
Permeabilized cells
Isolated mitochondria
Enzyme
RatSkeletal muscle
Nervous system
Liver
Other cell lines
Shabalina 2013 Abstract IOC792013Shabalina IG (2013) Enhanced Complex I but low Complex II substrate-derived ROS production rates in mice, prematurely aging due to enhanced mitochondrial DNA mutation rate. Mitochondr Physiol Network 18.07LEAK
OXPHOS
ETS
N
S
NS
Isolated mitochondriaMouseHeart
Skeletal muscle
Liver
Shabalina 2013 Abstract MiP20132013Shabalina IG, Petrovic N, Kalinovich AV, Cannon B, Nedergaard J (2013) Comparative study of brown and white adipose tissue mitochondria in mice upon cold acclimation. Mitochondr Physiol Network 18.08.OXPHOS
ETS
GpIsolated mitochondriaFat
Gnaiger 2013 Abstract Mito20132013Gnaiger E, Søndergaard H, Munch-Andersen T, Damsgaard R, Hagen C, Díez-Sánchez C, Ara I, Wright-Paradis C, Schrauwen P, Hesselink M, Calbet J, Christiansen M, Helge JW, Saltin B, Boushel R (2013) Conserved mitochondrial coupling efficiency and adaptive substrate control in Inuit and Caucasians: adaptation and acclimatization to the Arctic winter.LEAK
OXPHOS
ETS
F
N
S
NS
Permeabilized tissueHumanSkeletal muscle
Matallo 2013 Abstract MiP20132013Matallo J, Gröger M, Wagner K, Wagner F, Radermacher P, Calzia E (2013) Effects of mechanical ventilation after blunt chest trauma on diaphragmatic mitochondrial respiration in chronically cigarette smoke exposed mice: A clinically relevant model? Mitochondr Physiol Network 18.08.ETSNSHomogenateMouseHeart
Lung;gill
Skeletal muscle
Skulachev 2013 Abstract MiP20132013Skulachev VP (2013) SkQ1, the first mitochondria-targeted medicine available in drugstores. Mitochondr Physiol Network 18.08.LEAK
ETS
Intact organism
Intact cells
Isolated mitochondria
SMP
Human
Mouse
Horse
Dog
Rabbit
Fishes
Other invertebrates
Fungi
Plants
Heart
Skeletal muscle
Nervous system
Kidney
Islet cell;pancreas;thymus
Other cell lines
HeLa
Fibroblast
Stem cells
Irving 2013 Abstract MiP20132013Irving BA, Stahl R, Kane CJ, Chernousov M, Argyropoulos G, Carey D (2013) Sex differences in murine mitochondrial oxidative capacity following a 24 week high-fat diet. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ETS
N
NS
Permeabilized tissue
Homogenate
MouseSkeletal muscle
Liver
Fat
Amoedo 2013 Abstract MiP20132013Amoêdo ND, Rodrigues MF, Pereira S, Melo F, Jasiulionis M, Galina A, Rumjanek FD(2013) Comparative biochemistry of tumorigenesis: role of mitochondria in the metastatic process. Mitochondr Physiol Network 18.08.ETS
LEAK
OXPHOS
ROUTINE
N
ROX
S
Enzyme
Intact cells
Permeabilized cells
MouseEndothelial;epithelial;mesothelial cell
Other cell lines
Slinde 2013 Abstract MiP20132013Slinde E, Egelandsdal B, Olsen RE (2013) Respiration of tissue and mitochondria from Atlantic salmon (Salmo salar, L) liver, muscle, heart, brain and blood. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ETS
N
ROX
Permeabilized tissue
Isolated mitochondria
Other mammals
Fishes
Heart
Liver
Blood cells
Oliveira MF 2013 Abstract MiP20132013Oliveira MF (2013) Comparative mitochondrial physiology in blood feeding insect vectors and parasites. Mitochondr Physiol Network 18.08.LEAK
ROUTINE
OXPHOS
ETS
F
N
S
Gp
CIV
ROX
Intact organism
Intact organ
Intact cells
Permeabilized cells
Permeabilized tissue
Homogenate
Human
Drosophila
Hexapods
Other invertebrates
Skeletal muscle
Neuroblastoma
Krumschnabel 2013 Abstract MiP20132013Krumschnabel G, Eigentler A, Fontana-Ayoub M, Draxl A, Fasching M, Gnaiger E (2013) Tissue homogenates for respiratory OXPHOS analysis in comparative mitochondrial physiology: mouse and trout – heart and liver. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ETS
N
S
NS
ROX
HomogenateMouse
Fishes
Heart
Nervous system
Liver
Garcia-Roves 2013 Abstract MiP20132013Garcia-Roves PM, Gonzalez-Franquesa A, Martinez-Navarro L, Fernandez-Ruiz R (2013) Metabolic flexibility before and after lifestyle intervention in a diet-induced type 2 diabetes animal model. Mitochondr Physiol Network 18.08.ETS
LEAK
OXPHOS
CIV
N
NS
S
Homogenate
Permeabilized cells
Permeabilized tissue
MouseFat
Islet cell;pancreas;thymus
Liver
Nervous system
Skeletal muscle
Calzia 2013 Abstract MiP20132013Calzia E, Wagner K, Wagner F, Groeger M, Matallo J, McCook O, Wachter U, Vogt J, Radermacher P (2013) Studying mitochondrial effects of sulfide. Does the species matter? Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ETS
Pig
Mouse
Liver
Votion 2013 Abstract MiP20132013Votion DM, Mouithys-Mickalad A, Ceusters Justine D, Lemieux H, Tosi I, Franck T, Art T, Niesten A, Serteyn D (2013) The challenge of understanding myopathies in horses using permeabilized muscle cells. Mitochondr Physiol Network 18.08.ETS
OXPHOS
F
N
NS
ROX
S
Permeabilized tissueHorseSkeletal muscle
Camacho-Pereira 2013 Abstract IOC752013Camacho-Pereira J (2013) CD38 as a regulator of mitochondrial function. Mitochondr Physiol Network 18.03.ETS
LEAK
OXPHOS
ROUTINE
N
NS
S
Intact cells
Isolated mitochondria
Permeabilized cells
MouseHEK
Liver
Macrophage-derived
Pichaud 2013 Abstract MiP20132013Pichaud N, Blier PU(2013) Importance of mitochondrial haplotypes in the expression of metabolic phenotypes under different conditions. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ETS
N
S
Gp
CIV
NS
ROX
Permeabilized tissueDrosophila
Hexapods
Skeletal muscle
Pecina 2013 Abstract MiP20132013Pecina P, Houšťková H, Mráček T, Pecinová A, Nůsková H, Tesařová M, Hansíková H, Janota J, Zeman J, Houštěk J (2013) The use of lymphocytes for diagnostics of mitochondrial oxidative phosphorylation disorders. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ETS
N
S
Gp
NS
Other combinations
ROX
Permeabilized cells
Homogenate
HumanBlood cells
Lymphocyte
Jezek 2013 Abstract MiP20132013Ježek P, Ježek J, Zelenka J, Dlasková A, Jabůrek M (2013) Antioxidant synergy of mitochondrial uncoupling protein UCP2 and phospholipase iPLA2γ. Mitochondr Physiol Network 18.08.LEAK
ROUTINE
OXPHOS
ETS
N
S
ROX
Intact cells
Isolated mitochondria
MouseLung;gill
Islet cell;pancreas;thymus
Chicco 2013 Abstract MiP20132013Chicco AJ, Le CH, Schlater A, Kanatous S (2013) Comparative muscle mitochondrial physiology of the northern elephant seal. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ETS
F
N
Other combinations
Permeabilized tissueHuman
Other mammals
Skeletal muscle
Zelenka J 2013 Abstract MiP20132013Zelenka J, Alan L, Jezek P(2013) Response of cancer cells to mitochondrial DNA damage. Mitochondr Physiol Network 18.08.ROUTINE
ETS
Other cell lines
Gnaiger 2013 Abstract MiP20132013Gnaiger E, Søndergaard H, Munch-Andersen T, Damsgaard R, Hagen C, Díez-Sánchez C, Ara I, Wright-Paradis C, Schrauwen P, Hesselink M, Calbet J, Christiansen M, Helge JW, Saltin B, Boushel R (2013) Biochemical coupling efficiency in permeabilized fibres from arm and leg muscle in Inuit versus Caucasians: A functional test of the uncoupling hypothesis in Greenland. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ETS
F
N
S
NS
Permeabilized tissueHumanSkeletal muscle
Rodrigues 2013 Abstract MiP20132013Rodrigues MF, Amoedo ND, Rumjanek FD (2013) Studies of bioenergetics alterations in breast cancer lines induced by histone desacetylase inhibitors. Mitochondr Physiol Network 18.08.LEAK
ROUTINE
ETS
ROXIntact cellsGenital
Garcia-Souza 2013 Abstract IOC802013Garcia-Souza LF (2013) Thrombin trigger mitochondrial functional remodeling in human platelets. Mitochondr Physiol Network 18.09.LEAK
ROUTINE
ETS
Intact cellsHumanBlood cells
Hand 2013 Abstract MiP20132013Hand SC, Patil Y (2013) Defense against ATP depletion during the energy-limited state of diapause. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ETS
N
S
Intact organism
Homogenate
Isolated mitochondria
Enzyme
Artemia
Crustaceans
Watala 2012 Abstract Bioblast2012Watala C, Przygodzki T, Siewiera K, Kassassir H, Talar M, Labieniec-Watala M (2012) Oxygen consumption in resting and activated blood platelets: platelet mitochondria and cyclooxygenases as compounding targets for high-resolution respirometry. Mitochondr Physiol Network 17.12.ROUTINE
ETS
NS
ROX
Intact cells
Isolated mitochondria
Enzyme
Human
Rat
Endothelial;epithelial;mesothelial cell
Blood cells
Platelet
Jacobs 2012 Abstract Bioblast2012Jacobs R, Lundby C (2012) Mitochondria express enhanced quality as well as quantity in parallel with aerobic fitness across recreationally active individuals up to elite athletes. Mitochondr Physiol Network 17.12.ETS
LEAK
OXPHOS
F
N
NS
S
Permeabilized cellsHumanSkeletal muscle
Towheed 2012 Abstract IOC722012Towheed A (2012) Elucidating pathogenesis of ATP synthase dysfunction in a Drosophila model of mitochondrial encephalomyopathy. Mitochondr Physiol Network 17.13.LEAK
ROUTINE
OXPHOS
ETS
N
S
NS
Intact organism
Permeabilized tissue
Drosophila
Hexapods
Doerrier 2012 Abstract Bioblast2012Doerrier C, Garcia JA, Escames G, Acuna-Castroviejo D (2012) Treatment with melatonin prevents myocardial mitochondrial dysfunction in experimental sepsis in mice. Mitochondr Physiol Network 17.12.LEAK
OXPHOS
ETS
N
S
NS
Permeabilized tissueMouseHeart
Rodrigues 2012 Abstract IOC722012Rodrigues MF, Amoedo ND, Rumjanek FD (2012) Studies of bioenergetics alterations in breast cancer lines induced by sodium butyrate. Mitochondr Physiol Network 17.13.LEAK
ROUTINE
ETS
Horscroft 2012 Abstract IOC722012Horscroft JA, Kotwica AO, Ashmore T, Colleoni F, Morash AJ, Gilbert E, Gnaiger E, Martin DS, Murray AJ (2012) Mitochondrial function at altitude in lowland Europeans and highland Sherpas. Mitochondr Physiol Network 17.13.LEAK
OXPHOS
ETS
N
NS
HumanSkeletal muscle
Hand 2012 Abstract Bioblast2012Patil Y, Gnaiger E, Hand SC (2012) Respiration in embryo lysates reveals diminished Complex I activity and inhibition of the phosphorylation system during diapause in Artemia franciscana. Mitochondr Physiol Network 17.12.OXPHOS
ETS
N
S
NS
HomogenateArtemia
Crustaceans
Horvath 2012 Abstract Bioblast2012Horvath G, Eigentler A, Gnaiger E, Tretter L (2012) Respiratory substrate effects on mitochondrial membrane potential - experiments with mouse cardiac muscle homogenate. Mitochondr Physiol Network 17.12.ETS
LEAK
OXPHOS
N
NS
S
HomogenateMouseHeart
Kamath 2012 Abstract IOC722012Kamath VG, Lizenby ZJ, Adusumilli VRKR, Hsiung CH, McKee EE (2012) Measuring mitochondrial OXPHOS as a nucleoside reverse transcriptase inhibitor induced cardiac toxicity endpoint. Mitochondr Physiol Network 17.13.LEAK
OXPHOS
ETS
Isolated mitochondriaRat
Labieniec-Watala 2012 Abstract Bioblast2012Labieniec-Watala M, Siewiera K, Watala C (2012) Seasonal fluctuations affect the physiology of laboratory animals – facts and artifacts from the perspective of heart mitochondrial respiratory response to tested compounds. Mitochondr Physiol Network 17.12.LEAK
OXPHOS
ETS
N
S
NS
Homogenate
Isolated mitochondria
Mouse
Rat
Heart
Liver
Fibroblast
Amoedo 2012 Abstract Bioblast2012Amoedo ND, Rodrigues MF, Pereira SAS, Melo FH, Jasiulionis MG, Galina A, Rumjanek FD (2012) Mitochondrial function and bioenergetics during malignant transformation and metastasis. Mitochondr Physiol Network 17.12.LEAK
ROUTINE
OXPHOS
ETS
SIntact cellsMouseOther cell lines
Le 2012 Abstract Bioblast2012Le CH, Hocker AD, Dreyer HC, Roach RC, Gnaiger E, Chicco AJ (2012) Two-week acclimatization to 5200m markedly alters substrate utilization and increases OXPHOS efficiency, with no effect on respiratory capacity in skeletal muscle mitochondria. Mitochondr Physiol Network 17.12.OXPHOS
ETS
N
S
Permeabilized tissueHumanSkeletal muscle
Albertini 2012 Abstract Bioblast2012Albertini E, Koziel R, Duerr A, Neuhaus M, Jansen-Duerr P (2012) Cystathionine beta synthase modulates senescence of human endothelial cells. Mitochondr Physiol Network 17.12.LEAK
ROUTINE
ETS
Intact cellsEndothelial;epithelial;mesothelial cell
HUVEC
Sumbalova 2011 Abstract Mitochondrial Medicine2011Sumbalova Z, Fasching M, Gnaiger E (2011) Substrate control in mitochondrial respiration and regulation of mitochondrial membrane potential. Abstract Mitochondrial Medicine Chicago.LEAK
OXPHOS
ETS
N
S
NS
Homogenate
Isolated mitochondria
MouseNervous system
Pesta 2011Abstract Mitochondrial Medicine-Training2011Pesta D, Hoppel F, Macek C, Messner H, Faulhaber M, Kobel C, Parson W, Burtscher M, Schocke M, Gnaiger E (2011) Mitochondrial improvements after strength, endurance, and intermittend hypoxic training in sedentary humans. A respiratory study on permeabilized muscle fibres. Abstract Mitochondrial Medicine Chicago.LEAK
OXPHOS
ETS
F
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Pesta 2010 MiP Abstract2010Pesta D, Faulhaber M, Burtscher M, Gnaiger E, Schocke M (2010) Investigation of muscle metabolism of the M. quadriceps via 31P MRS and high-resolution respirometry in connection with 10 weeks of strength and endurance training in normoxia and hypoxia. MiP2010.LEAK
OXPHOS
ETS
F
N
S
NS
Human
Matallo MiP20102010Matallo J, Reich V, Calzia E, Radermacher P, Groeger M (2010) Interactions between sulfide and mitochondrial respiration in cultured murine alveolar macrophage. Abstract. MiP2010.OXPHOS
ETS
N
S
Permeabilized cellsLung;gill
Macrophage-derived
Amoedo 2010 Abstract MiP20102010Amoêdo ND, Rodrigues MF, Pezutto P, Lourenço MVC, Madeiro da Costa RF, Oliveira MF, Galina A, Rumjanek FD, El-Bacha T (2010) Metabolic reprogramming of lung cancer cell induced by sodium butyrate: Studies on mitochondrial physiology and bioenergetics. Mitochondr Physiol Network 15.06.OXPHOS
ETS
Intact cellsHumanEndothelial;epithelial;mesothelial cell
Fibroblast