Dyscoupled respiration

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Dyscoupled respiration

Description

Dyscoupled respiration is LEAK respiration distinguished from intrinsically (physiologically) uncoupled and from extrinsic experimentally uncoupled respiration as an indication of extrinsic uncoupling (pathological, toxicological, pharmacological by agents that are not specifically applied to induce uncoupling, but are tested for their potential dyscoupling effect). Dyscoupling indicates a mitochondrial dysfunction.

In addition to intrinsic uncoupling, dyscoupling occurs under pathological and toxicological conditions. Thus a distinction is made between physiological uncoupling and pathologically defective dyscoupling in mitochondrial respiration.


Reference: Gnaiger 2014 MitoPathways


MitoPedia concepts: Respiratory state 


MitoPedia methods: Respirometry 




Coupling efficiency: from 0 to <1

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