ROUTINE respiration

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MitoPedia

ROUTINE respiration

Description

R.jpg In the intact cell, ROUTINE respiration or ROUTINE activity in the physiological coupling state R, is controlled by cellular energy demand, energy turnover and the degree of coupling to phosphorylation (intrinsic uncoupling and pathological dyscoupling). The conditions for measurement and expression of respiration vary (oxygen flux in state R, JO2R or oxygen flow in state R, IO2R). If these conditions are defined and remain consistent within a given context, then the simple symbol R for respiratory state can be used to substitute the more explicit expression for respiratory activity. R and growth of cells is supported by exogenous substrates in culture media. In media without energy substrates, R depends on endogenous substrates. R cannot be measured in permeabilized cells or isolated mitochondria. R is corrected for residual oxygen consumption (ROX), whereas R´ is the uncorrected apparent ROUTINE respiration or total cellular oxygen consumption of cells including ROX.

Abbreviation: R

Reference: Gnaiger 2014 MitoPathways, Gnaiger_2008_POS


MitoPedia concepts: Respiratory state, Recommended 


MitoPedia methods: Respirometry 


MitoPedia topics: EAGLE 

Contributed by Gnaiger E 2010-09-18, edited 2014-08-25.
Coupled energy cycles and and proton circuit of mitochondrial respiration in intact cells controlled by aerobic ATP demand in the ROUTINE state of activity. 2[H] indicates the reduced hydrogen equivalents of CHO substrates and electron transfer to oxygen, with a variety of energy substrates from carbohydrates through glycolysis to the tricarboxylic acid cycle (TCA) and glycerophosphate dehydrogenase complex (CGpDH), amino acid oxidation (AAO) and fatty acid oxidation (FAO through the electron transferring flavoprotein complex, CETF). H+out are protons pumped out of the matrix phase to the positive P-phase. Proton flow to the negative matrix phase (H+in) drives the phosphorylation of ADP to ATP. Proton leaks dissipate energy of translocated protons from the positive P-phase to the negative N-phase (modified after Gnaiger 2012 MitoPathways).


Why not 'basal respiration', and what about 'State 3.5'?

Basal respiration or "basal metabolic rate" is frequently used as LEAK respiration. Importantly, we have to make a clear distinction between (oligomycin-inhibited) LEAK respiration and physiologically controlled ROUTINE respiration, none of which conform to the physiological definition of basal respiration.


Related terms in Bioblast

P.jpg OXPHOS, P
R.jpg ROUTINE, R
E.jpg ETS, E
L.jpg LEAK, L
ROX.jpg ROX, R


Publications in the MiPMap

List of publications: ROUTINE

Sort in ascending/descending order by a click on one of the small symbols in squares below.
Default sorting: chronological. Empty fields appear first in ascending order. 
 YearReferenceCouplingPathwayPreparationOrganismTissue;cell
MiPNet15.09. Yeast: HRR Reference Assay2017-02-05
O2k-Protocols
A mitochondrial reference assay for high-resolution respirometry using freeze-dried Baker’s yeast.
ROUTINE
ETS
ROXSaccharomyces cerevisiae
Fungi
MiPNet21.17 BloodCellsIsolation2016-11-14
O2k-Protocols
O2k-Protocols: Isolation of blood cells for HRR.
LEAK
ROUTINE
OXPHOS
ETS
F
N
S
Gp
CIV
NS
ROX
Intact cells
Permeabilized cells
MouseBlood cells
Lymphocyte
Platelet
MiPNet08.09 CellRespiration2016-08-11
O2k-Protocols contents
High-resolution respirometry and coupling control protocol with intact cells: ROUTINE, LEAK, ETS, ROX.
LEAK
ROUTINE
ETS
Intact cellsHumanBlood cells
Lymphocyte
MiPNet10.04 CellRespiration2016-08-08
O2k-Protocols
An experiment with high-resolution respirometry: coupling control in cell respiration.
LEAK
ROUTINE
ETS
ROXIntact cellsMouseBlood cells
Cheng 2016 Nat Immunol2016Cheng SC, Scicluna BP, Arts RJ, Gresnigt MS, Lachmandas E, Giamarellos-Bourboulis EJ, Kox M, Manjeri GR, Wagenaars JA, Cremer OL, Leentjens J, van der Meer AJ, van de Veerdonk FL, Bonten MJ, Schultz MJ, Willems PH, Pickkers P, Joosten LA, van der Poll T, Netea MG (2016) Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis. Nat Immunol 17:406-13.LEAK
ROUTINE
ETS
ROXIntact cellsHumanBlood cells
Lymphocyte
Oliveira 2016 PLOS ONE2016Oliveira MP, Correa Soares JB, Oliveira MF (2016) Sexual preferences in nutrient utilization regulate oxygen consumption and reactive oxygen species generation in Schistosoma mansoni: potential implications for parasite redox biology. PLOS ONE 11:e0158429.LEAK
ROUTINE
F
ROX
Intact organismOther invertebrates
Chennamsetty 2016 Cell Rep2016Chennamsetty I, Coronado M, Contrepois K, Keller MP, Carcamo-Orive I, Sandin J, Fajardo G, Whittle AJ, Fathzadeh M, Snyder M, Reaven G, Attie AD, Bernstein D, Quertermous T, Knowles JW (2016) Nat1 deficiency is associated with mitochondrial dysfunction and exercise intolerance in mice. Cell Rep 17:527-40.ROUTINEIntact organ
Isolated mitochondria
MouseHeart
Fat
Jang 2016 J Intensive Care Med2016Jang DH, Greenwood JC, Spyres MB, Eckmann D (2016) Measurement of mitochondrial respiration and motility in acute care: sepsis, trauma, and poisoning. J Intensive Care Med 32:86-94.LEAK
ROUTINE
ETS
ROXIntact cellsBlood cells
Lymphocyte
Cacabelos 2016 Neurobiol Dis2016Cacabelos D, Ayala V, Granado-Serrano AB, Jové M, Torres P, Boada J, Cabré R, Ramírez-Núñez O, Gonzalo H, Soler-Cantero A, Serrano JC, Bellmunt MJ, Romero MP, Motilva MJ, Nonaka T, Hasegawa M, Ferrer I, Pamplona R, Portero-Otín M (2016) Interplay between TDP-43 and docosahexaenoic acid-related processes in amyotrophic lateral sclerosis. Neurobiol Dis 88:148-60.ROUTINEIntact cellsRatNervous system
Schaefer 2016 PLOS ONE2016Schaefer PM, von Einem B, Walther P, Calzia E, von Arnim CA (2016) Metabolic characterization of intact cells reveals intracellular amyloid beta but not its precursor protein to reduce mitochondrial respiration. PLOS ONE 11:e0168157.LEAK
ROUTINE
ETS
CIV
ROX
Intact cellsHuman
Mouse
Nervous system
HEK
Bynum 2016 Transfusion2016Bynum JA, Adam Meledeo M, Getz TM, Rodriguez AC, Aden JK, Cap AP, Pidcoke HF (2016) Bioenergetic profiling of platelet mitochondria during storage: 4°C storage extends platelet mitochondrial function and viability. Transfusion 56 Suppl 1:S76-84.LEAK
ROUTINE
ETS
ROXIntact cellsHumanBlood cells
Platelet
Sheremet 2016 Biochemistry (Moscow)2016Sheremet NL, Nevinitsyna TA, Zhorzholadze NV, Ronzina IA, Itkis YS, Krylova TD, Tsygankova PG, Malakhova VA, Zakharova EY, Tokarchuk AV, Panteleeva AA, Karger EM, Lyamzaev KG, Avetisov SE (2016) Previously unclassified mutation of mtDNA m.3472T>C: evidence of pathogenicity in Leber’s hereditary optic neuropathy. Biochemistry (Moscow) BM16-078.LEAK
ROUTINE
OXPHOS
ETS
N
S
NS
ROX
Intact cells
Permeabilized cells
HumanEndothelial;epithelial;mesothelial cell
Fibroblast
Platelet
Anand 2016 PLOS ONE2016Anand R, Strecker V, Urbach J, Wittig I, Reichert AS (2016) Mic13 is essential for formation of crista junctions in mammalian cells. PLOS ONE 11:e0160258.LEAK
ROUTINE
OXPHOS
ETS
N
CIV
NS
Other combinations
ROX
Intact cells
Permeabilized cells
HEK
Lores-Arnaiz 2016 Neurochem Res2016Lores-Arnaiz S, Lombardi P, Karadayian AG, Orgambide F, Cicerchia D, Bustamante J (2016) Brain cortex mitochondrial bioenergetics in synaptosomes and non-synaptic mitochondria during aging. Neurochem Res 41:353-63.LEAK
ROUTINE
OXPHOS
ETS
N
S
Intact cells
Isolated mitochondria
MouseNervous system
MiPNet21.12 Comparison mt respiration media2016
O2k-Protocols
O2k-MultiSensor: Mitochondrial respiration media for HRR and simultaneous O2k-Fluorometry.
LEAK
ROUTINE
OXPHOS
ETS
N
S
NS
ROX
Intact cells
Permeabilized cells
HumanHEK
Vevera 2016 Physiol Res2016Vevera J, Fišar Z, Nekovářová T, Vrablík M, Zlatohlávek L, Hroudová J, Singh N, Raboch J, Valeš K (2016) Statin-induced changes in mitochondrial respiration in blood platelets in rats and human with dyslipidemia. Physiol Res 65:777-88.LEAK
ROUTINE
OXPHOS
ETS
N
S
NS
Other combinations
ROX
Intact cells
Permeabilized cells
Human
Rat
Blood cells
Platelet
Macheiner 2016 Sci Rep2016Macheiner T, Fengler VH, Agreiter M, Eisenberg T, Madeo F, Kolb D, Huppertz B, Ackbar R, Sargsyan K (2016) Magnetomitotransfer: An efficient way for direct mitochondria transfer into cultured human cells. Sci Rep 6:35571.LEAK
ROUTINE
ETS
ROXFibroblast
Zelenka 2016 Oxid Med Cell Longev2016Zelenka J, Dvořák A, Alán L, Zadinová M, Haluzík M, Vítek L (2016) Hyperbilirubinemia protects against aging-associated inflammation and metabolic deterioration. Oxid Med Cell Longev ID 6190609:10p.ROUTINEIntact cells
Isolated mitochondria
RatLiver
Kidney
Fibroblast
McFarlane 2016 Thesis2016McFarlane SV (2016) Temperature-dependent alterations of brown adipose tissue metabolism during hibernation in the thirteen-lined ground squirrel, Ictidomys tridecemlineatus. Dissertation p74.LEAK
OXPHOS
ROUTINE
F
N
Intact cells
Isolated mitochondria
Other mammalsFat
Lesage 2016 Am J Hum Genet2016Lesage S, Drouet V, Majounie E, Deramecourt V, Jacoupy M, Nicolas A, Cormier-Dequaire F, Hassoun SM, Pujol C, Ciura S, Erpapazoglou Z, Usenko T, Maurage CA, Sahbatou M, Liebau S, Ding J, Bilgic B, Emre M, Erginel-Unaltuna N, Guven G, Tison F, Tranchant C, Vidailhet M, Corvol JC, Krack P, Leutenegger AL, Nalls MA, Hernandez DG, Heutink P, Gibbs JR, Hardy J, Wood NW, Gasser T, Durr A, Deleuze JF, Tazir M, Destée A, Lohmann E, Kabashi E, Singleton A, Corti O, Brice A (2016) Loss of VPS13C function in autosomal-recessive parkinsonism causes mitochondrial dysfunction and increases PINK1/Parkin-Dependent Mitophagy. Am J Hum Genet 98:500-13.LEAK
ROUTINE
ETS
ROXIntact cellsOther mammalsKidney
Other cell lines
Rohlenova 2016 Antioxid Redox Signal2016Rohlenova K, Sachaphibulkij K, Stursa J, Bezawork-Geleta A, Blecha J, Endaya B, Werner L, Cerny J, Zobalova R, Goodwin J, Spacek T, Alisadeh E, Yan B, Nguyen M, Vondrusova M, Sobol M, Jezek P, Hozak P, Truksa J, Rohlena J, Dong L, Neuzil J (2016) Selective disruption of respiratory supercomplexes as a new strategy to suppress Her2high breast cancer. Antioxid Redox Signal 26:84-103.LEAK
ROUTINE
ETS
N
S
Other combinations
Permeabilized cells
Homogenate
Human
Mouse
Liver
Genital
Other cell lines
Peruzzo 2016 Cell Cycle2016Peruzzo P, Comelli M, Di Giorgio E, Franforte E, Mavelli I, Brancolini C (2016) Transformation by different oncogenes relies on specific metabolic adaptations. Cell Cycle 15:2656-68.LEAK
ROUTINE
ETS
ROXIntact cellsMouseFibroblast
Valek 2016 Redox Biol2016Valek L, Häussler A, Dröse S, Eaton P, Schröder K, Tegeder I (2016) Redox-guided axonal regrowth requires cyclic GMP dependent protein kinase 1: Implication for neuropathic pain. Redox Biol 11:176-91.ROUTINE
OXPHOS
N
S
CIV
HomogenateMouseNervous system
MiPNet21.14 Reference sample HRR2016
O2k-Protocols
Development of a reference sample for HRR.
LEAK
ROUTINE
OXPHOS
ETS
F
N
S
Gp
CIV
NS
Other combinations
ROX
Intact cells
Permeabilized cells
HumanHEK
Boeck 2016 Mitochondrion2016Boeck C, Koenig AM, Schury K, Geiger ML, Karabatsiakis A, Wilker S, Waller C, Gündel H, Fegert JM, Calzia E, Kolassa IT (2016) Inflammation in adult women with a history of child maltreatment: The involvement of mitochondrial alterations and oxidative stress. Mitochondrion 30:197-207.LEAK
ROUTINE
ETS
ROXIntact cellsHumanBlood cells
Lymphocyte
Stier 2016 Methods Ecol Evol2016Stier A, Romestaing C, Schull Q, Lefol E, Robin JP, Roussel D, Bize P (2016) How to measure mitochondrial function in birds using red blood cells: a case study in the king penguin and perspectives in ecology and evolution. Methods Ecol Evol doi:10.1111/2041-210X.12724.LEAK
ROUTINE
OXPHOS
ETS
N
S
ROX
Intact cellsBirdsSkeletal muscle
Blood cells
Puskarich 2016 J Crit Care2016Puskarich MA, Kline JA, Watts JA, Shirey K, Hosler J, Jones AE (2016) Early alterations in platelet mitochondrial function are associated with survival and organ failure in patients with septic shock. J Crit Care 31:63-7.LEAK
ROUTINE
ETS
ROXIntact cellsHumanBlood cells
Platelet
Camacho-Pereira 2016 Cell Metab2016Camacho-Pereira J, Tarragó MG, Chini CC, Nin V, Escande C, Warner GM, Puranik AS, Schoon RA, Reid JM, Galina A, Chini EN (2016) CD38 dictates age-related NAD decline and mitochondrial dysfunction through an SIRT3-dependent mechanism. Cell Metab 23:1127-39.ETS
LEAK
OXPHOS
ROUTINE
ROX
S
Intact cells
Isolated mitochondria
Human
Mouse
Liver
Lung;gill
Other cell lines
Drehmer 2016 Stem Cell Res2016Drehmer DL, de Aguiar AM, Brandt AP, Petiz L, Cadena SM, Rebelatto CK, Brofman PR, Filipak Neto F, Dallagiovanna B, Abud AP (2016) Metabolic switches during the first steps of adipogenic stem cells differentiation. Stem Cell Res 17:413-421.LEAK
ROUTINE
ETS
ROXHumanFat
Stem cells
Jang 2016 Clin Toxicol (Phila)2016Jang DH, Shofer FS, Weiss SL, Becker LB (2016) Impairment of mitochondrial respiration following ex vivo cyanide exposure in peripheral blood mononuclear cells. Clin Toxicol (Phila) 54:303-7.LEAK
ROUTINE
ETS
ROXIntact cellsHumanBlood cells
Lymphocyte
Sanchez-Calvo 2016 PLOS ONE2016Sánchez-Calvo B, Cassina A, Rios N, Peluffo G, Boggia J, Radi R, Rubbo H, Trostchansky A (2016) Nitro-arachidonic acid prevents Angiotensin II-induced mitochondrial dysfunction in a cell line of kidney proximal tubular cells. PLOS ONE 11:e0150459.LEAK
ROUTINE
ETS
ROXIntact cellsHumanKidney
Other cell lines
Tsai 2016 Sci Rep2016Tsai HH, Chang SC, Chou CH, Weng TP, Hsu CC, Wang JS (2016) Exercise training alleviates hypoxia-induced mitochondrial dysfunction in the lymphocytes of sedentary males. Sci Rep 6:35170.LEAK
ROUTINE
OXPHOS
ETS
F
N
S
NS
Other combinations
ROX
Intact cells
Permeabilized cells
HumanLymphocyte
Moll 2016 bioRxiv2016Moll CWI, Lindtner RA, Vogel GF, Brunner M, Gutleben K, Blauth M, Krumschnabel G, Ebner HL (2016) Bone marrow mesenchymal stem cells from osteoporotic patients do not show altered mitochondrial energetics or ultrastructure. bioRxiv doi.org/10.1101/046300.LEAK
ROUTINE
OXPHOS
ETS
N
S
ROX
Intact cells
Permeabilized cells
HumanStem cells
Ehinger 2016 Mov Disord2016Ehinger JK, Morota S, Hansson MJ, Gesine P, Elmér E (2016) Mitochondrial respiratory function in peripheral blood cells from Huntington’s disease patients. Mov Disord doi:10.1002/mdc3.12308.LEAK
ROUTINE
OXPHOS
ETS
N
S
CIV
NS
Other combinations
ROX
Intact cells
Permeabilized cells
HumanBlood cells
Lymphocyte
Platelet
Reynolds 2016 Am J Physiol Endocrinol Metab2016Reynolds MS, Hancock CR, Ray JD, Kener KB, Draney C, Garland K, Hardman J, Bikman BT, Tessem JS (2016) β-cell deletion of Nr4a1 and Nr4a3 nuclear receptors impedes mitochondrial respiration and insulin secretion. Am J Physiol Endocrinol Metab 311:E186-201.LEAK
ROUTINE
OXPHOS
ETS
N
S
ROX
Intact cells
Permeabilized cells
RatIslet cell;pancreas;thymus
Davuluri 2016 Proc Natl Acad Sci U S A2016Davuluri G, Song P, Liu Z, Wald D, Sakaguchi TF, Green MR, Devireddy L (2016) Inactivation of 3-hydroxybutyrate dehydrogenase 2 delays zebrafish erythroid maturation by conferring premature mitophagy. Proc Natl Acad Sci U S A 113:E1460-9.LEAK
ROUTINE
ETS
Intact cellsZebrafishBlood cells
Heimer 2016 Am J Hum Genet2016Heimer G, Kerätär JM, Riley LG, Balasubramaniam S, Eyal E, Pietikäinen LP, Hiltunen JK, Marek-Yagel D, Hamada J, Gregory A, Rogers C, Hogarth P, Nance MA, Shalva N, Veber A, Tzadok M, Nissenkorn A, Tonduti D, Renaldo F, Kraoua I, Panteghini C, Valletta L, Garavaglia B, Cowley MJ, Gayevskiy V, Roscioli T, Silberstein JM, Hoffmann C, Raas-Rothschild A, Tiranti V, Anikster Y, Christodoulou J, Kastaniotis AJ, Ben-Zeev B, Hayflick SJ (2016) MECR mutations cause childhood-onset dystonia and optic atrophy, a mitochondrial fatty acid synthesis disorder. Am J Hum Genet 99:1229-44.LEAK
ROUTINE
ETS
ROXIntact cellsHuman
Siewiera 2016 Life Sci2016Siewiera K, Kassassir H, Talar M, Wieteska L, Watala C (2016) Higher mitochondrial potential and elevated mitochondrial respiration are associated with excessive activation of blood platelets in diabetic rats. Life Sci 148:293-304.LEAK
ROUTINE
ETS
ROXIntact cellsRatBlood cells
Platelet
Kawalec 2016 Praca doktorska2016Kawalec MM (2016) Badanie komórkowych skutków mutacji w genie mitofuzyny 2. Próba zaproponowania testu patogenności mutacji. Praca doktorska p86.LEAK
ROUTINE
ETS
Intact cellsMouseFibroblast
Du 2016 Thesis2016Du X (2016) Anthropogenic pollution effects on mitochondrial energy metabolism, gene expression, and genotypes of natural Fundulus heteroclitus populations. Dissertation p175.LEAK
ROUTINE
OXPHOS
ETS
S
CIV
Other combinations
ROX
FishesLiver
Gdynia 2016 Nat Commun2016Gdynia G, Sauer SW, Kopitz J, Fuchs D, Duglova K, Ruppert T, Miller M, Pahl J, Cerwenka A, Enders M, Mairbäurl H, Kamiński MM, Penzel R, Zhang C, Fuller JC, Wade RC, Benner A, Chang-Claude J, Brenner H, Hoffmeister M, Zentgraf H, Schirmacher P, Roth W (2016) The HMGB1 protein induces a metabolic type of tumour cell death by blocking aerobic respiration. Nat Commun 7:10764.ROUTINEROXPermeabilized cellsHumanEndothelial;epithelial;mesothelial cell
Other cell lines
Barison 2016 J Bioenerg Biomembr2016Barisón MJ, Damasceno FS, Mantilla BS, Silber AM (2016) The active transport of histidine and its role in ATP production in Trypanosoma cruzi. J Bioenerg Biomembr 48:437-49.LEAK
ROUTINE
ETS
Intact cellsProtists
Brandt 2016 Chem Biol Interact2016Brandt AP, Gozzi GJ, Pires Ado R, Martinez GR, Dos Santos Canuto AV, Echevarria A, Di Pietro A, Cadena SM (2016) Impairment of oxidative phosphorylation increases the toxicity of SYD-1 on hepatocarcinoma cells (HepG2). Chem Biol Interact 256:154-60.LEAK
ROUTINE
ETS
ROXIntact cellsHumanLiver
Other cell lines
Cacabelos 2016 Acta Neuropathol Commun2016Cacabelos D, Ramírez-Núñez O, Granado-Serrano AB, Torres P, Ayala V, Moiseeva V, Povedano M, Ferrer I, Pamplona R, Portero-Otin M, Boada J (2016) Early and gender-specific differences in spinal cord mitochondrial function and oxidative stress markers in a mouse model of ALS. Acta Neuropathol Commun 4:3.LEAK
ROUTINE
OXPHOS
ETS
N
S
NS
ROX
Intact cells
Permeabilized tissue
MouseNervous system
Other cell lines
Bastow 2016 J Cell Sci2016Bastow EL, Peswani AR, Tarrant DS, Pentland DR, Chen X, Morgan A, Staniforth GL, Tullet JM, Rowe ML, Howard MJ, Tuite MF, Gourlay CW (2016) New links between SOD1 and metabolic dysfunction from a yeast model of amyotrophic lateral sclerosis. J Cell Sci 129:4118-29.ETS
LEAK
ROUTINE
ROXSaccharomyces cerevisiae
Salvi 2016 Oxid Med Cell Longev2016Salvi A, Patki G, Khan E, Asghar M, Salim S (2016) Protective effect of tempol on buthionine sulfoximine (BSO)-induced mitochondrial impairment in hippocampal derived HT22 cells. Oxid Med Cell Longev 2016:5059043.ROUTINEIntact cellsMouseNervous system
Other cell lines
Holandino 2016 Bioelectrochemistry2016Holandino C, Teixeira CA, de Oliveira FA, Barbosa GM, Siqueira CM, Messeder DJ, de Aguiar FS, da Veiga VF, Girard-Dias W, Miranda K, Galina A, Capella MA, Morales MM (2016) Direct electric current treatment modifies mitochondrial function and lipid body content in the A549 cancer cell line. Bioelectrochemistry 111:83-92.LEAK
ROUTINE
ETS
ROXIntact cellsHumanLung;gill
Other cell lines
Frey 2016 Biochim Biophys Acta2016Frey S, Geffroy G, Desquiret-Dumas V, Gueguen N, Bris C, Belal S, Amati-Bonneau P, Chevrollier A, Barth M, Henrion D, Lenaers G, Bonneau D, Reynier P, Procaccio V (2016) The addition of ketone bodies alleviates mitochondrial dysfunction by restoring complex I assembly in a MELAS cellular model. Biochim Biophys Acta 1863:284-91.ROUTINEIntact cells
Permeabilized cells
HumanNervous system
Castellano-Gonzalez 2016 Oncotarget2016Castellano-González G, Pichaud N, Ballard JW, Bessede A, Marcal H, Guillemin GJ (2016) Epigallocatechin-3-gallate induces oxidative phosphorylation by activating cytochrome c oxidase in human cultured neurons and astrocytes. Oncotarget 7:7426-40LEAK
ROUTINE
ETS
ROXIntact cellsHumanNervous system
Barth 2016 Thesis2016Barth C (2016) Effekte einer intermittierenden Hyperoxie auf die mitochondriale Atmung in Alveolarmakrophagen. Dissertation p69.LEAK
ROUTINE
OXPHOS
N
S
CIV
NS
ROX
Intact cells
Permeabilized cells
MouseLung;gill
Macrophage-derived
Larsen 2016 FASEB J2016Larsen FJ, Schiffer TA, Ørtenblad N, Zinner C, Morales-Alamo D, Willis SJ, Calbet JA, Holmberg HC, Boushel R (2016) High-intensity sprint training inhibits mitochondrial respiration through aconitase inactivation. FASEB J 30:417-27.LEAK
ROUTINE
OXPHOS
N
NS
Intact cells
Permeabilized cells
Isolated mitochondria
HumanSkeletal muscle
Xiong 2016 Hypertension2016Xiong S, Wang P, Ma L, Gao P, Gong L, Li L, Li Q, Sun F, Zhou X, He H, Chen J, Yan Z, Liu D, Zhu Z (2016) Ameliorating endothelial mitochondrial dysfunction restores coronary function via transient receptor potential vanilloid 1-mediated protein kinase A/uncoupling protein 2 pathway. Hypertension 67:451-60.LEAK
ROUTINE
OXPHOS
ETS
N
S
NS
ROX
Intact cells
Permeabilized cells
HumanEndothelial;epithelial;mesothelial cell
Other cell lines
Zhunussova 2016 PLOS ONE2016Zhunussova A, Vitol EA, Polyak B, Tuleukhanov S, Brooks AD, Sensenig R, Friedman G, Orynbayeva Z (2016) Mitochondria-mediated anticancer effects of non-thermal atmospheric plasma. PLOS ONE 11:e0156818.LEAK
ROUTINE
ETS
Intact cellsHumanGenital
Other cell lines
Watala 2016 Int J Pharm2016Watala C, Karolczak K, Kassassir H, Siewiera K, Maczynska K, Pieniazek A, Labieniec-Watala M (2016) How do the full-generation poly(amido)amine (PAMAM) dendrimers activate blood platelets? Platelet membrane zeta potential and other membrane-associated phenomena. Int J Pharm 500:379-89.LEAK
ROUTINE
ETS
ROXIntact cellsHumanBlood cells
Platelet
Schinagl 2016 PLoS One2016Schinagl CW, Vrabl P, Burgstaller W (2016) Adapting high-resolution respirometry to glucose-limited steady state mycelium of the filamentous fungus Penicillium ochrochloron: method development and standardisation. PLoS One 11:e0146878.ROUTINE
ETS
Intact cellsFungi
Chubanov 2016 Elife2016Chubanov V, Ferioli S, Wisnowsky A, Simmons DG, Leitzinger C, Einer C, Jonas W, Shymkiv Y, Bartsch H, Braun A, Akdogan B, Mittermeier L, Sytik L, Torben F, Jurinovic V, van der Vorst EP, Weber C, Yildirim ÖA, Sotlar K, Schürmann A, Zierler S, Zischka H, Ryazanov AG, Gudermann T (2016) Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival. Elife 5. pii: e20914.ROUTINE
ETS
ROXIntact cellsHumanFibroblast
Scrima 2016 Biochim Biophys Acta2016Scrima R, Cela O, Merla G, Augello B, Rubino R, Quarato G, Fugetto S, Menga M, Fuhr L, Relógio A, Piccoli C, Mazzoccoli G, Capitanio N (2016) Clock-genes and mitochondrial respiratory activity: Evidence of a reciprocal interplay. Biochim Biophys Acta 1857:1344-51.LEAK
ROUTINE
ETS
ROXIntact cellsHumanLiver
Endothelial;epithelial;mesothelial cell
Other cell lines
Fibroblast
Sengupta 2016 Free Radic Biol Med2016Sengupta S, Yang G, O'Donnell JC, Hinson MD, McCormack SE, Falk MJ, La P, Robinson MB, Williams ML, Yohannes MT, Polyak E, Nakamaru-Ogiso E, Dennery PA (2016) The circadian gene Rev-erbα improves cellular bioenergetics and provides preconditioning for protection against oxidative stress. Free Radic Biol Med 93:177-89.LEAK
ROUTINE
ETS
ROXIntact cellsMouseLung;gill
Fibroblast
Torres 2016 Redox Biol2016Torres S, Matías N, Baulies A, Nuñez S, Alarcon-Vila C, Martinez L, Nuño N, Fernandez A, Caballeria J, Levade T, Gonzalez-Franquesa A, Garcia-Rovés P, Balboa E, Zanlungo S, Fabrías G, Casas J, Enrich C, Garcia-Ruiz C, Fernández-Checa JC (2016) Mitochondrial GSH replenishment as a potential therapeutic approach for Niemann Pick type C disease. Redox Biol 11:60-72.LEAK
ROUTINE
OXPHOS
ETS
N
S
ROX
HomogenateHuman
Mouse
Nervous system
Liver
Endothelial;epithelial;mesothelial cell
Fibroblast
MiPNet18.06 Amplex-Yeast2015-06-15
O2k-Protocols
O2k-Fluorometry: Amplex® UltraRed using freeze-dried baker’s yeast.
ROUTINE
ETS
Intact cellsSaccharomyces cerevisiae
Fungi
Lehtola 2015 Master's Thesis2015Lehtola A (2015) Main protein component of high density lipoprotein, apolipoprotein A1, modulates leukocyte cell respiration. Master's Thesis 1-44.LEAK
ROUTINE
OXPHOS
ETS
N
S
NS
ROX
Intact cells
Permeabilized cells
HumanBlood cells
Other cell lines
Lymphocyte
Grimm 2015 Exp Gerontol2015Grimm C, Osiewacz HD (2015) Manganese rescues adverse effects on lifespan and development in Podospora anserina challenged by excess hydrogen peroxide. Exp Gerontol 63:8-17.ROUTINECIV
ROX
Intact cells
Isolated mitochondria
Fungi
Falabella 2015 Oxid Med Cell Longev2015Falabella M, Forte E, Magnifico MC, Santini P, Arese M, Giuffrè A, Radić K, Chessa L, Coarelli G, Buscarinu MC, Mechelli R, Salvetti M, Sarti P (2015) Evidence for detrimental cross interactions between reactive oxygen and nitrogen species in Leber’s hereditary optic neuropathy cells. Oxid Med Cell Longev 3187560.ROUTINEROXIntact cellsHumanBlood cells
Lymphocyte
Makrecka-Kuka 2015 Biomolecules2015
O2k-Protocols contents
Makrecka-Kuka M, Krumschnabel G, Gnaiger E (2015) High-resolution respirometry for simultaneous measurement of oxygen and hydrogen peroxide fluxes in permeabilized cells, tissue homogenate and isolated mitochondria. Biomolecules 5:1319-38.
LEAK
ROUTINE
OXPHOS
ETS
N
S
NS
ROX
Intact cells
Permeabilized cells
Homogenate
Isolated mitochondria
Human
Mouse
Heart
Nervous system
HEK
Du 2015 J Biol Chem2015Du J, Rountree A, Cleghorn WM, Contreras L, Lindsay KJ, Sadilek M, Gu H, Djukovic D, Raftery D, Satrustegui J, Kanow M, Chan L, Tsang SH, Sweet IR, Hurley JB (2015) Phototransduction influences metabolic flux and nucleotide metabolism in mouse retina. J Biol Chem 291:4698-710.LEAK
ROUTINE
OXPHOS
ETS
N
ROX
Isolated mitochondriaMouseNervous system
Islet cell;pancreas;thymus
Orynbayeva 2015 Nanomedicine (Lond)2015Orynbayeva Z, Sensenig R, Polyak B (2015) Metabolic and structural integrity of magnetic nanoparticle-loaded primary endothelial cells for targeted cell therapy. Nanomedicine (Lond) 10:1555-68.LEAK
ROUTINE
ETS
ROXIntact cellsRatEndothelial;epithelial;mesothelial cell
Ikaga 2015 Biochem Biophys Rep2015Ikaga R, Namekatac I, Kotiadisd VN, Ogawab H, Duchend MR, Tanakac H, Iida-Tanakab N (2015) Knockdown of aquaporin-8 induces mitochondrial dysfunction in 3T3-L1 cells. Biochem Biophys Rep 4:187–95.ETS
LEAK
ROUTINE
CIV
ROX
Intact cellsMouseFat
Other cell lines
Ruiz-Perez 2015 J Biol Chem2015Ruiz-Pérez MV, Medina MÁ, Urdiales JL, Keinänen TA, Sánchez-Jiménez F (2015) Polyamine metabolism is sensitive to glycolysis inhibition in human neuroblastoma cells. J Biol Chem 290:6106-19.LEAK
ROUTINE
ETS
ROXIntact cellsHumanNervous system
Other cell lines
Neuroblastoma
Renner 2015 Eur J Immunol2015Renner K, Geiselhöringer AL, Fante M, Bruss C, Färber S, Schönhammer G, Peter K, Singer K, Andreesen R, Hoffmann P, Oefner P, Herr W, Kreutz M (2015) Metabolic plasticity of human T cells: Preserved cytokine production under glucose deprivation or mitochondrial restriction, but 2-deoxy-glucose affects effector functions. Eur J Immunol 45:2504-16.LEAK
ROUTINE
ETS
Intact cellsHumanBlood cells
Lymphocyte
Van Rahden 2015 Am J Hum Genet2015van Rahden VA, Fernandez-Vizarra E, Alawi M, Brand K, Fellmann F, Horn D, Zeviani M, Kutsche K (2015) Mutations in NDUFB11, encoding a complex I component of the mitochondrial respiratory chain, cause microphthalmia with linear skin defects syndrome. Am J Hum Genet 96:640-50.LEAK
ROUTINE
ETS
Intact cellsHumanHeLa
Yan 2015 BMC Cancer2015Yan B, Stantic M, Zobalova R, Bezawork-Geleta A, Stapelberg M, Stursa J, Prokopova K, Dong L, Neuzil J (2015) Mitochondrially targeted vitamin E succinate efficiently kills breast tumour-initiating cells in a complex II-dependent manner. BMC Cancer 15:401.ETS
LEAK
OXPHOS
ROUTINE
N
NS
ROX
S
Intact cells
Permeabilized cells
Human
Mouse
Genital
Other cell lines
Zhunussova 2015 Am J Cancer Res2015Zhunussova A, Sen B, Friedman L, Tuleukhanov S, Brooks AD, Sensenig R, Orynbayeva Z (2015) Tumor microenvironment promotes dicarboxylic acid carrier-mediated transport of succinate to fuel prostate cancer mitochondria. Am J Cancer Res 5:1665-79.ETS
ROUTINE
SIntact cells
Permeabilized cells
Human
Rat
Endothelial;epithelial;mesothelial cell
Genital
Other cell lines
Ofer 2015 Mol Endocrinol2015Ofer P, Heidegger I, Eder IE, Schöpf B, Neuwirt H, Geley S, Klocker H, Massoner P (2015) Both IGF1R and INSR knockdown exert anti-tumorigenic effects in prostate cancer in vitro and in vivo. Mol Endocrinol 29:1694-707.ROUTINE
OXPHOS
ETS
F
N
NS
Intact cells
Permeabilized cells
HumanGenital
Other cell lines
Keane 2015 Clin Sci (Lond)2015Keane KN, Calton EK, Cruzat VF, Soares MJ, Newsholme P (2015) The impact of cryopreservation on human peripheral blood leukocyte bioenergetics. Clin Sci (Lond) 128:723–33.ROUTINE
ETS
Intact cellsHumanBlood cells
Lee 2015 Methods Mol Biol2015Lee W, Kelly RD, Yeung KY, Cagnone G, McKenzie M, John JC (2015) Analysis of mitochondrial DNA in induced pluripotent and embryonic stem cells. Methods Mol Biol 1330:219-52.LEAK
ROUTINE
ETS
ROXIntact cellsMouseStem cells
Alonso-Vale 2015 FASEB J2015Alonso-Vale MI, Cruz M, Bolsoni-Lopes A, de Sá R, Bresciani Martins de Andrade P (2015) Palmitoleic acid (C16:1n7) treatment enhances fatty acid oxidation and oxygen consumption in white adipocytes. FASEB J 29:884.25.ROUTINEIntact cellsMouseFat
Taferner 2015 PLoS One2015Taferner A, Pircher H, Koziel R, von Grafenstein S, Baraldo G, Palikaras K, Liedl KR, Tavernarakis N, Jansen-Dürr P (2015) FAH domain containing protein 1 (FAHD-1) is required for mitochondrial function and locomotion activity in C. elegans. PLoS One 10(8):e0134161.ROUTINEIntact organismCaenorhabditis elegans
Nematodes
Aroor 2015 Diabetes2015Aroor AR, Habibi J, Ford DA, Nistala R, Lastra G, Manrique C, Dunham MM, Ford KD, Thyfault JP, Parks EJ, Sowers JR, Rector RS (2015) Dipeptidyl peptidase-4 inhibition ameliorates western diet-induced hepatic steatosis and insulin resistance through hepatic lipid remodeling and modulation of hepatic mitochondrial function. Diabetes 64:1988-2001.ETS
LEAK
OXPHOS
ROUTINE
F
N
NS
S
Isolated mitochondriaMouseLiver
Tesori 2015 Sci Rep2015Tesori V, Piscaglia AC, Samengo D, Barba M, Bernardini C, Scatena R, Pontoglio A, Castellini L, Spelbrink JN, Maulucci G, Puglisi MA, Pani G, Gasbarrini A (2015) The multikinase inhibitor Sorafenib enhances glycolysis and synergizes with glycolysis blockade for cancer cell killing. Sci Rep 5:9149.LEAK
ROUTINE
ETS
Intact cellsRatLiver
Other cell lines
Stem cells
Ma 2015 Int J Biol Sci2015Ma W, Jing L, Valladares A, Mehta SL, Wang Z, Li PA, Bang JJ (2015) Silver nanoparticle exposure induced mitochondrial stress, caspase-3 activation and cell death: amelioration by sodium selenite. Int J Biol Sci 11:860-7.ROUTINEIntact cellsMouseNervous system
Other cell lines
Garama 2015 Mol Cell Biol2015Garama DJ, Harris TJ, White CL, Rossello FJ, Abdul-Hay M, Gough DJ, Levy DE (2015) A Synthetic Lethal Interaction between Glutathione Synthesis and Mitochondrial Reactive Oxygen Species Provides a Tumor-Specific Vulnerability Dependent on STAT3. Mol Cell Biol 35(21):3646-56.LEAK
ROUTINE
ETS
Intact cellsMouseEndothelial;epithelial;mesothelial cell
Fibroblast
Truksa 2015 Antioxid Redox Signal2015Truksa J, Dong L, Rohlena J, Stursa J, Vondrusova M, Goodwin J, Nguyen M, Kluckova K, Rychtarcikova Z, Lettlova S, Spacilova J, Stapelberg M, Zoratti M, Neuzil J (2015) Mitochondrially targeted vitamin E succinate modulates expression of mitochondrial DNA transcripts and mitochondrial biogenesis. Antioxid Redox Signal 22:883-900.ROUTINESIntact cellsHuman
Mouse
Genital
Other cell lines
Plecita-Hlavata 2015 J Bioenerg Biomembr2015Plecitá-Hlavatá L, Ježek J, Ježek P (2015) Aglycemia keeps mitochondrial oxidative phosphorylation under hypoxic conditions in HepG2 cells. J Bioenerg Biomembr 47(6):467-76.LEAK
ROUTINE
ETS
Intact cellsHumanLiver
Lim 2015 Am J Cancer Res2015Lim SC, Carey KT, McKenzie M (2015) Anti-cancer analogues ME-143 and ME-344 exert toxicity by directly inhibiting mitochondrial NADH: ubiquinone oxidoreductase (Complex I). Am J Cancer Res 5:689-701.LEAK
ROUTINE
OXPHOS
N
S
Intact cells
Permeabilized cells
Isolated mitochondria
HumanKidney
Other cell lines
HEK
HeLa
Fibroblast
Lourenco 2015 Front Aging Neurosci2015Lourenço CF, Ledo A, Dias C, Barbosa RM, Laranjinha J (2015) Neurovascular and neurometabolic derailment in aging and Alzheimer's disease. Front Aging Neurosci 7:103.ROUTINE
ETS
ROXIntact cellsMouseNervous system
Dueregger 2015 PLoS One2015Dueregger A, Schöpf B, Eder T, Höfer J, Gnaiger E, Aufinger A, Kenner L, Perktold B, Ramoner R, Klocker H, Eder IE (2015) Differential utilization of dietary fatty acids in benign and malignant cells of the prostate. PLoS One 10(8):e0135704.LEAK
ROUTINE
OXPHOS
ETS
F
N
NS
ROX
Permeabilized cells
Permeabilized tissue
HumanGenital
Other cell lines
Tan 2015 Cell Metab2015Tan AS, Baty JW, Dong L, Bezawork-Geleta A, Endaya B, Goodwin J, Bajzikova M, Kovarova J, Peterka M, Yan B, Pesdar EA, Sobol M, Filimonenko A, Stuart S, Vondrusova M, Kluckova K, Sachaphibulkij K, Rohlena J, Hozak P, Truksa J, Eccles D, Haupt LM, Griffiths LR, Neuzil J, Berridge MV (2015) Mitochondrial genome acquisition restores respiratory function and tumorigenic potential of cancer cells without mitochondrial DNA. Cell Metab 21:81-94.LEAK
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OXPHOS
ETS
N
S
NS
ROX
Intact cells
Permeabilized cells
Isolated mitochondria
Human
Mouse
Endothelial;epithelial;mesothelial cell
Genital
Other cell lines
Peyta 2015 Biochim Biophys Acta2015Peyta L, Jarnouen K, Pinault M, Coulouarn C, Guimaraes C, Goupille C, de Barros JP, Chevalier S, Dumas JF, Maillot F, Hatch GM, Loyer P, Servais S (2015) Regulation of hepatic cardiolipin metabolism by TNFα: Implication in cancer cachexia. Biochim Biophys Acta 1851:1490-500.LEAK
ROUTINE
OXPHOS
ETS
NSIntact cells
Permeabilized cells
RatLiver
Other cell lines
Rodrigues 2016 Biochem J2015Rodrigues MF, Obre E, Melo FH, Santos-Jr GC, Galina A, Jasiulionis MG, Rossignol R, Rumjanek FD, Amoedo ND (2016) Enhanced OXPHOS, glutaminolysis and beta-oxidation constitute the metastatic phenotype of melanoma cells. Biochem J 473:703-15.LEAK
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OXPHOS
ETS
F
N
S
ROX
Intact cells
Permeabilized cells
MouseEndothelial;epithelial;mesothelial cell
Other cell lines
Blatzer 2015 Antioxid Redox Signal2015Blatzer M, Jukic E, Posch W, Schöpf B, Binder U, Steger M, Blum G, Hackl H, Gnaiger E, Lass-Flörl C, Wilflingseder D (2015) Amphotericin B resistance in Aspergillus terreus is overpowered by co-application of pro-oxidants. Antioxid Redox Signal 23:1424-38.ROUTINEROXIntact cellsFungi
Plecita-Hlavata 2015 Am J Respir Cell Mol Biol2015Plecitá-Hlavatá L, Tauber J, Li M, Zhang H, Flockton AR, Pullamsetti SS, Chelladurai P, D'alessandro A, El Kasmi KC, Ježek P, Stenmark KR (2015) Constitutive reprogramming of fibroblast mitochondrial metabolism in pulmonary hypertension. Am J Respir Cell Mol Biol 55:47-57.LEAK
ROUTINE
OXPHOS
ETS
N
CIV
Other combinations
Intact cells
Isolated mitochondria
Human
Bovines
Endothelial;epithelial;mesothelial cell
Fibroblast
Martinez 2015 Thesis2015Martínez Gasca B (2015) Generacion de modelos celulares para el estudio del efecto fenotipico de la variacion genetica en el mtDNA. Thesis 1-35.ROUTINEIntact cellsHumanLiver
Other cell lines
Rodrigues 2015 J Cell Biochem2015Rodrigues MF, Carvalho É, Pezzuto P, Rumjanek FD, Amoêdo ND (2015) Reciprocal modulation of histone deacetylase inhibitors sodium butyrate and trichostatin a on the energy metabolism of breast cancer cells. Int J Biochem Cell Biol 116:797-808.LEAK
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OXPHOS
ETS
ROXIntact cellsHumanEndothelial;epithelial;mesothelial cell
Other cell lines
Luevano-Martinez 2015 Biochim Biophys Acta2015Luévano-Martínez LA, Forni MF, Dos Santos VT, Souza-Pinto NC, Kowaltowski AJ (2015) Cardiolipin is a key determinant for mtDNA stability and segregation during mitochondrial stress. Biochim Biophys Acta 1847:587-98.ROUTINE
ETS
ROXIntact cellsSaccharomyces cerevisiae
Fungi
Duskova 2015 Mol Microbiol2015Dušková M, Ferreira C, Lucas C, Sychrová H (2015) Two glycerol uptake systems contribute to the high osmotolerance of Zygosaccharomyces rouxii. Mol Microbiol 97:541-59.ROUTINEIntact cellsFungi
Six 2015 Cell Death Dis2015Six E, Lagresle-Peyrou C, Susini S, De Chappedelaine C, Sigrist N, Sadek H, Chouteau M, Cagnard N, Fontenay M, Hermine O, Chomienne C, Reynier P, Fischer A, André-Schmutz I, Gueguen N, Cavazzana M (2015) AK2 deficiency compromises the mitochondrial energy metabolism required for differentiation of human neutrophil and lymphoid lineages. Cell Death Dis 6:e1856.LEAK
ROUTINE
ETS
ROXIntact cellsHumanBlood cells
Other cell lines
Bernhardt 2015 Sci Rep2015Bernhardt D, Müller M, Reichert AS, Osiewacz HD (2015) Simultaneous impairment of mitochondrial fission and fusion reduces mitophagy and shortens replicative lifespan. Sci Rep 5:7885.ROUTINE
ETS
ROXIntact cellsSaccharomyces cerevisiae
Schirris 2015 Cell Metab2015Schirris TJ, Renkema GH, Ritschel T, Voermans NC, Bilos A, van Engelen BG, Brandt U, Koopman WJ, Beyrath JD, Rodenburg RJ, Willems PH, Smeitink JA, Russel FG (2015) Statin-induced myopathy is associated with mitochondrial complex III inhibition. Cell Metab 22:399-407.ROUTINE
OXPHOS
ETS
N
S
Gp
CIV
NS
ROX
Permeabilized cellsHuman
Mouse
Skeletal muscle
Other cell lines
Li 2015 Sci Rep2015Li P, Wang B, Sun F, Li Y, Li Q, Lang H, Zhao Z, Gao P, Zhao Y, Shang Q, Liu D, Zhu Z (2015) Mitochondrial respiratory dysfunctions of blood mononuclear cells link with cardiac disturbance in patients with early-stage heart failure. Sci Rep 5:10229.LEAK
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OXPHOS
ETS
N
S
NS
Intact cellsHumanBlood cells
Lymphocyte
Coupling control protocol2015Gnaiger E (2015) From PCP to CCP. Mitochondr Physiol Network 2015-01-11.LEAK
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OXPHOS
ETS
Madsen 2015 Nat Commun2015Madsen CT, Sylvestersen KB, Young C, Larsen SC, Poulsen JW, Andersen MA, Palmqvist EA, Hey-Mogensen M, Jensen PB, Treebak JT, Lisby M, Nielsen ML (2015) Biotin starvation causes mitochondrial protein hyperacetylation and partial rescue by the SIRT3-like deacetylase Hst4p. Nat Commun 6:7726.ROUTINE
ETS
Intact cellsSaccharomyces cerevisiae
Boss 2015 US Patent2015Boss OD, Crisan M, Giacobino JP, (2015) Brown adipocyte progenitors in human sceletal muscle. US Patent US 2015/0240206 A1.LEAK
ROUTINE
ETS
ROXPermeabilized cellsHuman
Mouse
Skeletal muscle
Endothelial;epithelial;mesothelial cell
Fat
Lages 2015 PeerJ2015Lages YM, Nascimento JM, Lemos GA, Galina A, Castilho LR, Rehen SK (2015) Low oxygen alters mitochondrial function and response to oxidative stress in human neural progenitor cells. PeerJ 3:e1486.ETS
LEAK
ROUTINE
ROXIntact cellsHumanStem cells
Smolkova 2015 Int J Biochem Cell Biol2015Smolková K, Dvořák A, Zelenka J, Vítek L, Ježek P (2015) Reductive carboxylation and 2-hydroxyglutarate formation by wild-type IDH2 in breast carcinoma cells. Int J Biochem Cell Biol 65:125-33.LEAK
ROUTINE
ETS
ROXIntact cellsHumanEndothelial;epithelial;mesothelial cell
Other cell lines
Kelly 2015 Biotechnol J2015Kelly PS, Breen L, Gallagher C, Kelly S, Henry M, Lao NT, Meleady P, O'Gorman D, Clynes M, Barron N (2015) Re-programming CHO cell metabolism using miR-23 tips the balance towards a highly productive phenotype. Biotechnol J 10:1029-40.LEAK
ROUTINE
OXPHOS
ETS
N
S
CIV
NS
ROX
Intact cells
Permeabilized cells
CHO
Jeger 2015 BioMed Res Internat2015Jeger V, Brandt S, Porta F, Jakob SM, Takala J, Djafarzadeh S (2015) Dose response of Endotoxin on hepatocyte and muscle mitochondrial respiration in vitro. BioMed Res Internat Article ID 353074:1-13.LEAK
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OXPHOS
ETS
N
S
CIV
NS
ROX
Intact cells
Permeabilized cells
Isolated mitochondria
HumanSkeletal muscle
Liver
Other cell lines
Assmann 2014 PhD Thesis2015Assman N (2015) Impact of Fanconi-associated protein on the mitochonrial proteome. PhD Thesis 1-111.LEAK
ROUTINE
OXPHOS
ETS
F
N
S
CIV
NS
ROX
Intact cells
Permeabilized cells
PigKidney
Other cell lines
Hendricks 2015 Thesis2015Hendricks EW (2015) The impact of aging and estrogen therapy on synaptic mitochondrial bioenergetics in an Alzheimer's mouse model. Master Thesis 1-67.LEAK
ROUTINE
OXPHOS
ETS
N
S
NS
ROX
Intact cells
Permeabilized cells
Isolated mitochondria
MouseNervous system
Martos 2015 Plant Physiol Biochem2015Martos GG, Terán Mdel M, Díaz Ricci JC (2015) The defence elicitor AsES causes a rapid and transient membrane depolarization, a triphasic oxidative burst and the accumulation of nitric oxide. Plant Physiol Biochem 97:443-50.ROUTINEIntact cellsPlants
Ehinger 2015 J Neurol2015Ehinger JK, Morota S, Hansson MJ, Paul G, Elmér E (2015) Mitochondrial dysfunction in blood cells from amyotrophic lateral sclerosis patients. J Neurol 262:1493-503.LEAK
ROUTINE
OXPHOS
ETS
N
S
CIV
NS
ROX
Intact cells
Permeabilized cells
HumanBlood cells
Lymphocyte
Platelet
Gupta 2015 PLoS Genet2015Gupta S, Radhakrishnan A, Raharja-Liu P, Lin G, Steinmetz LM, Gagneur J, Sinha H (2015) Temporal expression profiling identifies pathways mediating effect of causal variant on phenotype. PLoS Genet 11:e1005195.ROUTINEIntact cellsFungi
Hagl 2015 Molecules2015Hagl S, Berressem D, Bruns B, Sus N, Frank J, Eckert GP (2015) Beneficial Effects of Ethanolic and Hexanic Rice Bran Extract on Mitochondrial Function in PC12 Cells and the Search for Bioactive Components. Molecules 20(9):16524-39.LEAK
ROUTINE
OXPHOS
ETS
N
S
CIV
NS
ROX
Permeabilized cellsRatNervous system
Other cell lines
Lisak 2015 Cell Death Differ2015Lisak D, Schacht T, Gawlitza A, Albrecht P, Aktas O, Koop B, Gliem M, Hofstetter HH, Zanger K, Bultynck G, Parys JB, De Smedt H, Kindler T, Adams-Quack P, Hahn M, Waisman A, Reed JC, Hövelmeyer N, Methner A (2015) BAX inhibitor-1 is a Ca2+ channel critically important for immune cell function and survival. Cell Death Differ 23:358-68.LEAK
ROUTINE
ETS
ROXIntact cellsMouseBlood cells
Lymphocyte
Seillier 2015 EMBO Mol Med2015Seillier M, Pouyet L, N'Guessan P, Nollet M, Capo F, Guillaumond F, Peyta L, Dumas JF, Varrault A, Bertrand G, Bonnafous S, Tran A, Meur G, Marchetti P, Ravier MA, Dalle S, Gual P, Muller D, Rutter GA, Servais S, Iovanna JL, Carrier A (2015) Defects in mitophagy promote redox-driven metabolic syndrome in the absence of TP53INP1. EMBO Mol Med 7:802-18.LEAK
ROUTINE
OXPHOS
ETS
F
CIV
NS
ROX
Intact cells
Permeabilized cells
Human
Mouse
Fibroblast
Sundaram 2015 Mol Microbiol2015Sundaram V, Petkova MI, Pujol-Carrion N, Boada J, de la Torre-Ruiz MA (2015) Tor1, Sch9 and PKA downregulation in quiescence rely on Mtl1 to preserve mitochondrial integrity and cell survival. Mol Microbiol 97:93-109.LEAK
ROUTINE
ETS
ROXIntact cellsSaccharomyces cerevisiae
Mallick 2015 Cell Calcium2015Mallick RL, Kumari S, Singh N, Sonkar VK, Dash D (2015) Prion protein fragment (106-126) induces prothrombotic state by raising platelet intracellular calcium and microparticle release. Cell Calcium 57:300-11.ROUTINEROXIntact cellsHumanBlood cells
Platelet
Schoettl 2015 Mol Metab2015Schöttl T, Kappler L, Fromme T, Klingenspor M (2015) Limited OXPHOS capacity in white adipocytes is a hallmark of obesity in laboratory mice irrespective of the glucose tolerance status. Mol Metab 4:631-42.LEAK
ROUTINE
OXPHOS
ETS
F
N
S
ROX
Intact cells
Isolated mitochondria
MouseFat
Other cell lines
Schoettl 2015 Endocrinology2015Schöttl T, Kappler L, Braun K, Fromme T, Klingenspor M (2015) Limited mitochondrial capacity of visceral versus subcutaneous white adipocytes in male C57BL/6N mice. Endocrinology 156:923-33.LEAK
ROUTINE
OXPHOS
ETS
N
S
ROX
Intact cells
Permeabilized cells
Isolated mitochondria
MouseFat
Farrar 2015 US Patent2015Farrar GJ, Millington-Ward S, Chadderton N (2015) Variants of yeast ndi1 gene, and uses thereof in the treatment of disease associated with mitochondrial dysfunction. US Patent WO 2013093029 A3.ROUTINEROXHumanHeLa
Venter 2015 J Clin Cell Immunol2015Venter G, Wijers M, Oerlemans FTJJ, Manjeri G, Fransen JAM, Wieringa B (2015) Glycolytic metabolism is differentially coupled to proliferative potential and morphodynamic capacity in RAW 264.7 and Mafb/C-Maf deficient macrophage lineages. J Clin Cell Immunol 6:1-11.LEAK
ROUTINE
ETS
ROXMouseBlood cells
Macrophage-derived
Neves 2015 Elife2015Neves A, Busso C, Gönczy P (2015) Cellular hallmarks reveal restricted aerobic metabolism at thermal limits. Elife 4:e04810.ROUTINEIntact organismCaenorhabditis elegans
Kilbaugh 2015 Exp Neurol2015Kilbaugh TJ, Karlsson M, Byro M, Bebee A, Ralston J, Sullivan S, Duhaime AC, Hansson MJ, Elmér E, Margulies SS (2015) Mitochondrial bioenergetic alterations after focal traumatic brain injury in the immature brain. Exp Neurol 271:136-144.LEAK
ROUTINE
OXPHOS
ETS
N
S
CIV
NS
ROX
Permeabilized tissue
Homogenate
PigNervous system
Llobet 2015 Dis Model Mech2015Llobet L, Toivonen JM, Montoya J, Ruiz-Pesini E, López-Gallardo E (2015) OXPHOS xenobiotics alter adipogenic differentiation at concentrations found in human blood. Dis Model Mech 8:1441-55.LEAK
ROUTINE
ETS
Intact cellsHumanFat
Stem cells
Birkenmeier 2015 Int J Cancer2015Birkenmeier K, Dröse S, Wittig I, Winkelmann R, Käfer V, Döring C, Hartmann S, Wenz T, Reichert AS, Brandt U, Hansmann ML (2015) Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma are highly dependent on oxidative phosphorylation. Int J Cancer 138:2231-46.LEAK
ROUTINE
ETS
CIV
ROX
HumanOther cell lines
HeLa
Macrophage-derived
Park 2015 Proc Natl Acad Sci USA2015Park JH, Kang HJ, Lee YK, Kang H, Kim J, Chung JH, Chang JS, McPherron AC, Lee SB (2015) Inactivation of EWS reduces PGC-1α protein stability and mitochondrial homeostasis. Proc Natl Acad Sci USA 112:6074-9.LEAK
ROUTINE
ETS
ROXIntact cellsMouseFat
Cassina 2015 Biol Reprod2015Cassina AM, Silveira P, Cantu L, Montes JM, Radi R, Sapiro R (2015) Defective Human sperm cells are associated with mitochondrial dysfunction and oxidant production. Biol Reprod 93:119.LEAK
ROUTINE
ETS
ROXHumanGenital
Hecker 2015 Methods Mol Biol2015Hecker M, Sommer N, Mayer K (2015) Assessment of short- and medium-chain fatty acids on mitochondrial function in severe Inflammation. Methods Mol Biol 1265:389-96.LEAK
ROUTINE
ETS
ROXIntact cellsHumanEndothelial;epithelial;mesothelial cell
Schoeckel 2015 Cancer Metab2015Schöckel L, Glasauer A, Basit F, Bitschar K, Truong H, Erdmann G, Algire C, Hägebarth A, Willems PH, Kopitz C, Koopman WJ, Héroult M (2015) Targeting mitochondrial complex I using BAY 87-2243 reduces melanoma tumor growth. Cancer Metab 3:11.ROUTINEROXIntact cellsHuman
Mouse
Endothelial;epithelial;mesothelial cell
Other cell lines
Grefte 2015 Biochim Biophys Acta2015Grefte S, Wagenaars JA, Jansen R, Willems PH, Koopman WJ (2015) Rotenone inhibits primary murine myotube formation via Raf-1 and ROCK2. Biochim Biophys Acta 1853:1606-14.ROUTINEIntact cellsMouseSkeletal muscle
Other cell lines
Kasvandik 2015 J Proteome Res2015Kasvandik S, Samuel K, Peters M, Eimre M, Peet N, Roost AM, Padrik L, Paju K, Peil L, Salumets A (2015) Deep quantitative proteomics reveals extensive metabolic reprogramming and cancer-like changes of ectopic endometriotic stromal cells. J Proteome Res 15:572-84.LEAK
ROUTINE
ETS
ROXHumanGenital
Other cell lines
Zelenka 2015 Oxid Med Cell Longev2015Zelenka J, Dvořák A, Alán L (2015) L-lactate protects skin fibroblasts against aging-associated mitochondrial dysfunction via mitohormesis. Oxid Med Cell Longev 2015:351698.LEAK
ROUTINE
ETS
N
S
Intact cells
Isolated mitochondria
RatLiver
Endothelial;epithelial;mesothelial cell
Fibroblast
Kawalec 2015 PLoS One2015Kawalec M, Boratyńska-Jasińska A, Beręsewicz M, Dymkowska D, Zabłocki K, Zabłocka B (2015) Mitofusin 2 deficiency affects energy metabolism and mitochondrial biogenesis in MEF cells. PLoS One 10:e0134162.ETS
LEAK
ROUTINE
Permeabilized cellsMouseFibroblast
Torelli 2015 Free Radic Biol Med2015Torelli NQ, Ferreira-Júnior JR, Kowaltowski AJ, da Cunha FM (2015) RTG1- and RTG2-dependent retrograde signaling controls mitochondrial activity and stress resistance in Saccharomyces cerevisiae. Free Radic Biol Med 81C:30-7.LEAK
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OXPHOS
ETS
CIV
ROX
Intact cells
Isolated mitochondria
Saccharomyces cerevisiae
Hals 2015 PLoS One2015Hals IK, Bruerberg SG, Ma Z, Scholz H, Björklund A, Grill V (2015) Mitochondrial respiration in insulin-producing β-cells: general characteristics and adaptive effects of hypoxia. PLoS One 10:e0138558.LEAK
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OXPHOS
ETS
N
S
NS
ROX
Intact cells
Permeabilized cells
RatIslet cell;pancreas;thymus
Other cell lines
Adlimoghaddam 2015 J Exp Biol2015Adlimoghaddam A, Boeckstaens M, Marini AM, Treberg JR, Brassinga AK, Weihrauch D (2015) Ammonia excretion in Caenorhabditis elegans: mechanism and evidence of ammonia transport of the Rhesus protein CeRhr-1. J Exp Biol 218:675-83.ROUTINEIntact organismCaenorhabditis elegans
Pasdar 2015 PLoS One2015Pasdar EA, Smits M, Stapelberg M, Bajzikova M, Stantic M, Goodwin J, Yan B, Stursa J, Kovarova J, Sachaphibulkij K, Bezawork-Geleta A, Sobol M, Filimonenko A, Tomasetti M, Zobalova R, Hozak P, Dong LF, Neuzil J (2015) Characterisation of mesothelioma-initiating cells and their susceptibility to anti-cancer agents. PLoS One 10:e0119549.LEAK
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OXPHOS
ETS
N
S
NS
Intact cells
Permeabilized cells
Human
Mouse
Endothelial;epithelial;mesothelial cell
Other cell lines
Khiati 2015 Proc Natl Acad Sci U S A2015Khiati S, Baechler SA, Factor VM, Zhang H, Huang SY, Dalla Rosa I, Sourbier C, Neckers L, Thorgeirsson SS, Pommier Y (2015) Lack of mitochondrial topoisomerase I (TOP1mt) impairs liver regeneration. Proc Natl Acad Sci U S A 112:11282-7.LEAK
ROUTINE
ETS
Intact cellsHumanEndothelial;epithelial;mesothelial cell
Other cell lines
Khera 2015 Placenta2015Khera A, Dong LF, Holland O, Vanderlelie J, Pasdar EA, Neuzil J, Perkins AV (2015) Selenium supplementation induces mitochondrial biogenesis in trophoblasts. Placenta 36:863-9.LEAK
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OXPHOS
ETS
N
S
CIV
Intact cells
Permeabilized cells
HumanGenital
Other cell lines
Kuznetsov 2015 Biochim Biophys Acta2015Kuznetsov AV, Javadov S, Sickinger S, Frotschnig S, Grimm M (2014) H9c2 and HL-1 cells demonstrate distinct features of energy metabolism, mitochondrial function and sensitivity to hypoxia-reoxygenation. Biochim Biophys Acta 1853:276-84.ROUTINE
ETS
Intact cellsRatHeart
Other cell lines
Banerjee 2015 Placenta2015Banerjee A, Weidinger A, Hofer M, Steinborn R, Lindenmair A, Hennerbichler-Lugscheider S, Eibl J, Redl H, Kozlov AV, Wolbank S (2015) Different metabolic activity in placental and reflected regions of the human amniotic membrane. Placenta 36:1329-32.ROUTINE
OXPHOS
ETS
NIntact cells
Permeabilized tissue
HumanGenital
Victorino 2015 Tumour Biol2015Victorino VJ, Barroso WA, Assunção AK, Cury V, Jeremias IC, Petroni R, Chausse B, Ariga SK, Herrera AC, Panis C, Lima TM, Souza HP (2015) PGC-1β regulates HER2-overexpressing breast cancer cells proliferation by metabolic and redox pathways. Tumour Biol 37:6035-44.LEAK
ROUTINE
ETS
ROXIntact cellsHumanGenital
Other cell lines
Cagnone 2015 Methods Mol Biol2015Cagnone G, Vaghjiani V, Lee W, Sun C, Johnson J, Yeung KY, St John JC (2015) Analysis of the mitochondrial DNA and its replicative capacity in induced pluripotent stem cells. Methods Mol Biol 1357:231-67.ETS
LEAK
ROUTINE
ROXIntact cellsHumanStem cells
Bock 2015 Thesis2015Bock UB (2015) Auswirkung von normobarer Hyperoxie auf die mitochondriale Atmung von Alveolarmakrophagen. Dissertation p80.LEAK
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OXPHOS
ETS
N
S
CIV
NS
ROX
Intact cells
Permeabilized cells
MouseLung;gill
Macrophage-derived
MiPNet12.01 Suppl T-issue2014-07-20
O2k-Protocols contents
MitoPathways at the Q-junction: mouse skeletal muscle fibres.
LEAK
ROUTINE
ETS
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Brahma 2014 J Lipid Res2014Brahma MK, Adam RC, Pollak NM, Jaeger D, Zierler KA, Poecher N, Schreiber R, Romauch M, Moustafa T, Eder S, Ruelicke T, Preiss-Landl K, Lass A, Zechner R, Haemmerle G (2014) Fibroblast growth factor 21 is induced upon cardiac stress and alters cardiac lipid homeostasis. J Lipid Res 55:2229-41.LEAK
ROUTINE
ETS
Intact cellsMouse
Rat
Heart
De Oliveira 2014 Cell Tiss Res2014De Oliveira GP, Cortez E, Araujo GJ, de Carvalho Sabino KC, Neves FA, Bernardo AF, de Carvalho SN, Moura AS, Carvalho L, Thole AA (2014) Impaired mitochondrial function and reduced viability in bone marrow cells of obese mice. Cell Tiss Res 357:185-94.LEAK
OXPHOS
ROUTINE
NSPermeabilized cellsMouseStem cells
Chakraborty 2014 J Cardiovasc Dis2014Chakraborty M, Phillips ARJ, Macdonald J, Windsor JA, Hickey AJR (2014) Mitochondrial respiration in mononuclear cells and heart fibers in spontaneously hypertensive rats. J Cardiovasc Dis ISSN:2330-459.LEAK
ROUTINE
OXPHOS
ETS
N
S
Gp
CIV
NS
ROX
Permeabilized cells
Permeabilized tissue
RatHeart
Blood cells
Hort 2014 Biochimie2014Hort MA, Straliotto MR, de Oliveira J, Amoêdo ND, da Rocha JB, Galina A, Ribeiro-do-Valle RM, de Bem AF (2014) Diphenyl diselenide protects endothelial cells against oxidized low density lipoprotein-induced injury: Involvement of mitochondrial function. Biochimie 105:172-81.LEAK
ROUTINE
ETS
Intact cellsBovinesOther cell lines
Fiuza 2014 Free Radic Res2014Fiuza B, Subelzú N, Calcerrada P, Straliotto MR, Piacenza L, Cassina A, Rocha JB, Radi R, de Bem AF, Peluffo G (2014) Impact of SIN-1-derived peroxynitrite flux on endothelial cell redox homeostasis and bioenergetics: protective role of diphenyl diselenide via induction of peroxiredoxins. Free Radic Res 49:122-32.LEAK
ROUTINE
ETS
Intact cellsBovinesEndothelial;epithelial;mesothelial cell
D'Aprile 2014 Stem Cells2014D'Aprile A, Scrima R, Quarato G, Tataranni T, Falzetti F, Di Ianni M, Gemei M, Del Vecchio L, Piccoli C, Capitanio N (2014) Hematopoietic stem/progenitor cells express myoglobin and neuroglobin: adaptation to hypoxia or prevention from oxidative stress? Stem Cells 32:1267-77.ROUTINEIntact cellsHumanStem cells
Karabatsiakis 2014 Transl Psychiatry2014Karabatsiakis A, Böck C, Salinas-Manrique J, Kolassa S, Calzia E, Dietrich DE, Kolassa IT (2014) Mitochondrial respiration in peripheral blood mononuclear cells correlates with depressive subsymptoms and severity of major depression. Transl Psychiatry 4:e397.LEAK
ROUTINE
ETS
ROXIntact cellsHumanBlood cells
Lymphocyte
Mishra 2014 Invest Ophthalmol Vis Sci2014Mishra M, Kowluru RA (2014) Retinal mitochondrial DNA mismatch repair in the development of diabetic retinopathy, and its continued progression after termination of hyperglycemia. Invest Ophthalmol Vis Sci. 55:6960-7.ROUTINEIntact cellsBovinesEndothelial;epithelial;mesothelial cell
Chini 2014 Clin Cancer Res2014Chini CC, Gonzalez Guerrico A, Nin V, Camacho-Pereira J, Escande C, Barbosa M, Chini EN (2014) Targeting of NAD metabolism in pancreatic cancer cells: potential novel therapy for pancreatic tumors. Clin Cancer Res 20:120-30.ROUTINE
ETS
Intact cellsHumanIslet cell;pancreas;thymus
Other cell lines
Bayot 2014 Biochimie2014Bayot A, Gareil M, Chavatte L, Hamon MP, L'hermitte-Stead C, Beaumatin F, Priault M, Rustin P, Lombès A, Friguet B, Bulteau AL (2014) Effect of Lon protease knockdown on mitochondrial function in HeLa cells. Biochimie 100:38-47.LEAK
ROUTINE
ETS
HumanEndothelial;epithelial;mesothelial cell
HeLa
Doridot 2014 Antioxid Redox Signal2014Doridot LD Chatre LD, Ducat A, Vilotte JL, Lombes A, Méhats C, Barbaux S, Calicchio R, Ricchetti M, Vaiman D (2014) Nitroso-redox balance and mitochondrial homeostasis are regulated by STOX1, a pre-eclampsia associated gene. Antioxid Redox Signal 21:819-34.LEAK
ROUTINE
ETS
ROXHumanEndothelial;epithelial;mesothelial cell
Other cell lines
Cotoia 2014 PLoS One2014Cotoia A, Scrima R, Gefter JV, Piccoli C, Cinnella G, Dambrosio M, Fink MP, Capitanio N (2014) p-Hydroxyphenylpyruvate, an intermediate of the Phe/ Tyr catabolism, improves mitochondrial oxidative metabolism under stressing conditions and prolongs survival in rats subjected to profound hemorrhagic shock. PLoS One 9:e90917.LEAK
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ETS
Intact cellsRat
Matallo 2014 Nitric Oxide2014Matallo J, Vogt J, McCook O, Wachter U, Tillmans F, Groeger M, Szabo C, Georgieff M, Radermacher P, Calzia E (2014) Sulfide-inhibition of mitochondrial respiration at very low oxygen concentrations. Nitric Oxide 15:79-84.ROUTINE
ETS
Intact cellsMouseLung;gill
Macrophage-derived
Glaser 2014 Thesis2014Glaser V (2014) Efeitos da hiperglicemia cronica e seus metabolitos, metilglioxal e produtos terminais de glicacao, na fisiologia e dinamica mitochondrial no sistema nervoso central. PhD Thesis 1-117.LEAK
ROUTINE
ETS
ROXIntact cellsRatNervous system
Other cell lines
Casanova 2014 Biochim Biophys Acta2014Casanova E, Baselga-Escudero L, Ribas-Latre A, Arola-Arnal A, Bladé C, Arola L, Salvadó MJ (2014) Epigallocatechin gallate counteracts oxidative stress in docosahexaenoxic acid-treated myocytes. Biochim Biophys Acta 1837:783-91.LEAK
ROUTINE
ETS
NIntact cellsRatSkeletal muscle
Other cell lines
Rudnicki 2014 United States Patent Application Publication2014Rudnicki MA, Yin Hang (2014) MICRORNA INHIBITORS. United States Patent Application Publication 1-49.LEAK
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OXPHOS
ETS
F
N
S
NS
ROX
Intact cells
Permeabilized cells
MouseSkeletal muscle
Fat
Felser 2014 Toxicology II2014Felser A, Lindinger PW, Schnell D, Kratschmar DV, Odermatt A, Mies S, Jenö P, Krähenbühl S (2014) Hepatocellular toxicity of benzbromarone: effects on mitochondrial function and structure. Toxicology 324:136-46.LEAK
ROUTINE
OXPHOS
ETS
N
S
ROX
Intact cellsHumanLiver
Other cell lines
Corona 2014 Exp Neurol2014Corona JC, de Souza SC, Duchen MR (2014) PPARγ activation rescues mitochondrial function from inhibition of 2 complex I and loss of PINK1. Exp Neurol 253:16-27.LEAK
ROUTINE
ETS
Intact cellsHumanNeuroblastoma
Piel 2014 Acta Physiol (Oxf)2014Piel S, Ehinger JK, Elmér E, Hansson Magnus J (2014) Metformin induces lactate production in peripheral blood mononuclear cells and platelets through specific mitochondrial complex I inhibition. Acta Physiol (Oxf) 213:171-80.LEAK
ROUTINE
OXPHOS
ETS
N
S
CIV
NS
ROX
Intact cells
Permeabilized cells
HumanBlood cells
Other cell lines
Platelet
Schmidl 2014 Blood2014Schmidl C, Renner K, Peter K, Eder R, Lassmann T, Balwierz PJ, Itoh M, Nagao-Sato S, Kawaji H, Carninci P, Suzuki H, Hayashizaki Y, Andreesen R, Hume DA, Hoffmann P, Forrest AR, Kreutz MP, Edinger M, Rehli M (2014) Transcription and enhancer profiling in human monocyte subsets. Blood 123:e90-9.ROUTINECIV
ROX
Intact cells
Permeabilized cells
HumanBlood cells
Ren 2014 Sci Rep2014Ren JG, Seth P, Clish CB, Lorkiewicz PK, Higashi RM, Lane AN, Fan TW, Sukhatme VP (2014) Knockdown of malic enzyme 2 suppresses lung tumor growth, induces differentiation and impacts PI3K/AKT signaling. Sci Rep 4:5414.ROUTINEIntact cellsHumanLung;gill
Other cell lines
Boczek 2014 Biomed Res Int2014Boczek T, Lisek M, Ferenc B, Kowalski A, Wiktorska M, Zylinska L (2014) Silencing of plasma membrane Ca2+-ATPase isoforms 2 and 3 impairs energy metabolism in differentiating PC12 cells. Biomed Res Int 2014:735106.LEAK
ROUTINE
ETS
RatNervous system
Other cell lines
Larsen 2014 Am J Clin Nutr2014Larsen FJ, Schiffer TA, Ekblom B, Mattsson MP, Checa A, Wheelock CE, Nyström T, Lundberg JO, Weitzberg E (2014) Dietary nitrate reduces resting metabolic rate: a randomized, crossover study in humans. Am J Clin Nutr 99:843-50.LEAK
ROUTINE
OXPHOS
Intact cells
Permeabilized cells
HumanSkeletal muscle
Stem cells
Logan 2014 Nat Genet2014Logan CV, Szabadkai G, Sharpe JA, Parry DA, Torelli S, Childs AM, Kriek M, Phadke R, Johnson CA, Roberts NY, Bonthron DT, Pysden KA, Whyte T, Munteanu I, Foley AR, Wheway G, Szymanska K, Natarajan S, Abdelhamed ZA, Morgan JE, Roper H, Santen GW, Niks EH, van der Pol WL, Lindhout D, Raffaello A, De Stefani D, den Dunnen JT, Sun Y, Ginjaar I, Sewry CA, Hurles M, Rizzuto R. UK10K Consortium, Duchen MR, Muntoni F, Sheridan E (2014) Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling. Nat Genet 46:188-93.LEAK
ROUTINE
ETS
ROXIntact cellsHumanFibroblast
Brandt 2014 Chem Biol Interact2014Brandt AP, do Rocio Andrade Pires A, Rocha ME, Noleto GR, Acco A, de Souza CE, Echevarria A, Dos Santos Canuto AV, Cadena SM (2014) Sydnone SYD-1 affects the metabolic functions of isolated rat hepatocytes. Chem Biol Interact 218C:107-14.LEAK
ROUTINE
ETS
ROXIntact cellsRatLiver
Carriere 2014 Diabetes2014Carrière A, Jeanson Y, Berger-Müller S, André M, Chenouard V, Arnaud E, Barreau C, Walther R, Galinier A, Wdziekonski B, Villageois P, Louche K, Collas P, Moro C, Dani C, Villarroya F, Casteilla L (2014) Browning of white adipose cells by intermediate metabolites: an adaptive mechanism to alleviate redox pressure. Diabetes 63:3253-65.LEAK
ROUTINE
ETS
Intact cellsMouseFat
Van Bergen 2014 Mitochondrion2014Van Bergen NJ, Blake RE, Crowston JG, Trounce IA (2014) Oxidative phosphorylation measurement in cell lines and tissues. Mitochondrion 15:24-33.LEAK
ROUTINE
OXPHOS
ETS
N
S
NS
Intact cells
Permeabilized cells
Isolated mitochondria
Human
Mouse
Nervous system
Blood cells
Lymphocyte
Cheng 2014 Science2014Cheng SC, Quintin J, Cramer RA, Shepardson KM, Saeed S, Kumar V, Giamarellos-Bourboulis EJ, Martens JH, Rao NA, Aghajanirefah A, Manjeri GR6, Li Y, Ifrim DC, Arts RJ, van der Meer BM, Deen PM, Logie C, O'Neill LA, Willems P, van de Veerdonk FL, van der Meer JW, Ng A, Joosten LA, Wijmenga C, Stunnenberg HG, Xavier RJ, Netea MG (2014) mTOR- and HIF-1 α –mediated aerobic glycolysis as metabolic basis for trained immunity. Science 345:1250684.LEAK
ROUTINE
ETS
HumanBlood cells
Other cell lines
Konickova 2014 Annals Hepatol2014Konickova R, Vankova K, Vanikova J, Vanova K, Muchova L, Subhanova I, Zadoinova M, Zelenka J, Dvorak A, Kolar M,Strnad H, Rimpelova S, Ruml T, Wong RJ, Vitek L (2014) Anti-cancer effects of blue-green alga Spirulina platensis, a natural source of bilirubin-like tetrapyrrolic compounds. Annals Hepatol 13:273-83.ROUTINE
ETS
HumanOther cell lines
Schoerner 2014 Thesis University Giessen2014Schörner S (2014) Changes in function of mitochondrial respiratory chain in pulmonary artery smooth muscle cells under conditions of chronic hypoxia : measurements by respirometry and remission-spectrophotometry. Thesis University Giessen 130 pp.LEAK
ROUTINE
ETS
ROXRabbitEndothelial;epithelial;mesothelial cell
Hirzel 2014 PhD Thesis2014Hirzel E (2014) Characterization of human bone marrow derived mesenchymal stem cells as a model for in vitro adipocytes studies. PhD Thesis 1-106.LEAK
ROUTINE
OXPHOS
ETS
N
NS
Intact cells
Permeabilized cells
HumanFat
Other cell lines
Kramer 2014 J Vis Exp2014Kramer PA, Chacko BK, Ravi S, Johnson MS, Mitchell T, Darley-Usmar VM (2014) Bioenergetics and the oxidative burst: protocols for the isolation and evaluation of human leukocytes and platelets. J Vis Exp 2014 Mar 27(85). doi: 10.3791/51301.LEAK
ROUTINE
ETS
Intact cellsHumanBlood cells
Platelet
Mandò 2014 Am J Physiol Endocrinol Metab2014Mandò C, De Palma C, Stampalija T, Anelli GM, Figus M, Novielli C, Parisi F, Clementi E, Ferrazzi E, Cetin I (2014) Placental mitochondrial content and function in intrauterine growth restriction and preeclampsia. Am J Physiol Endocrinol Metab 306:E404-13.ROUTINE
OXPHOS
N
S
CIV
NS
ROX
Intact cells
Permeabilized cells
HumanGenital
Widmann 2014 Thesis2014Widmann M (2014) Effekte von Noradrenalin und LPS auf die mitochondriale Atmung von Alveolarmakrophagen. Thesis Universität Ulm, Medizinische Fakultät. 63 pp.LEAK
ROUTINE
ETS
ROXIntact cellsMouseLung;gill
Other cell lines
Di Noia 2014 J Biol Chem2014Di Noia MA, Todisco S, Cirigliano A, Rinaldi T, Agrimi G, Iacobazzi V, Palmieri F (2014) The human SLC25A33 and SLC25A36 genes of solute carrier family 25 encode two mitochondrial pyrimidine nucleotide transporters. J Biol Chem 289:33137-48.ROUTINE
ETS
Intact cellsSaccharomyces cerevisiae
Gnaiger 2014 MitoPathways2014
O2k-Protocols
Gnaiger E (2014) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 4th ed. Mitochondr Physiol Network 19.12. OROBOROS MiPNet Publications, Innsbruck:80 pp.
LEAK
ROUTINE
OXPHOS
ETS
F
N
S
Gp
CIV
NS
ROX
Intact cells
Permeabilized cells
Permeabilized tissue
Homogenate
Isolated mitochondria
Human
Mouse
Heart
Skeletal muscle
Fibroblast
Hereng 2014 Human Reprod2014Hereng TH, Elgstoen KBP, Eide L, Rosendal KR, Skalhegg BS (2014) Serum albumin and HCO3 2 regulate separate pools of ATP in human spermatozoa. Human Reprod 29:918-30.ETS
LEAK
ROUTINE
Intact cellsHumanGenital
Breton-Romero 2014 Biochim Biophys Acta2014Bretón-Romero R, Acín-Perez R, Rodríguez-Pascual F, Martínez-Molledo M, Brandes RP, Rial E, Enríquez JA, Lamas S (2014) Laminar shear stress regulates mitochondrial dynamics, bioenergetics responses and PRX3 activation in endothelial cells. Biochim Biophys Acta 1843:2403-13.ROUTINEIntact cellsEndothelial;epithelial;mesothelial cell
HUVEC
Sonkar 2014 FASEB J2014Sonkar VK, Kulkarni PP, Dash D (2014) Amyloid beta peptide stimulates platelet activation through RhoA-dependent modulation of actomyosin organization. FASEB J 28:1819-29.LEAK
ROUTINE
ROXIntact cellsHuman
Mouse
Blood cells
Platelet
Hecker 2014 JPEN2014Hecker M, Sommer N, Voigtmann H, Pak O, Mohr A, Wolf M, Vadász I, Herold S, Weissmann N, Morty R, Seeger W, Mayer K (2014) Impact of short- and medium-chain fatty acids on mitochondrial function in severe inflammation. J Parenter Enteral Nutr 38:587-94.LEAK
ROUTINE
ETS
Intact cellsHumanEndothelial;epithelial;mesothelial cell
Blood cells
HUVEC
Zhang 2013 PLoS One2013Zhang Z, Tsukikawa M, Peng M, Polyak E, Nakamaru-Ogiso E, Ostrovsky J, McCormack S, Place E, Clarke C, Reiner G, McCormick E, Rappaport E, Haas R, Baur JA, Falk MJ (2013) Primary respiratory chain disease causes tissue-specific dysregulation of the global transcriptome and nutrient-sensing signaling network. PLoS One 8:e69282.LEAK
ROUTINE
OXPHOS
ETS
NIntact cells
Permeabilized cells
HumanFibroblast
Casanova 2013 Thesis Universitat Rovira i Virgili - Spain2013Casanova Vallvé E (2013) Modulation of Mmuscle energy metabolism by bioactive compounds. Thesis Universitat Rovira i Virgili - Spain 117pp.ROUTINE
ETS
N
S
NS
ROX
Intact cellsRatSkeletal muscle
Dutta 2013 Autophagy2013Dutta D, Xu J, Kim J-S, Dunn WA Jr, Leeuwenburgh C (2013) Upregulated autophagy protects cardiomyocytes from oxidative stress-induced toxicity. Autophagy 9:328-44.ROUTINEIntact cellsMouseHeart
Perales Villarroel 2013 J Surg Res2013Perales Villarroel JP, Figueredo R, Guan Y, Tomaiuolo M, Karamercan MA, Welsh J, Selak MA, Becker LB, Sims C (2013) Increased platelet storage time is associated with mitochondrial dysfunction and impaired platelet function. J Surg Res 184:422-9.ROUTINE
OXPHOS
ETS
N
S
NS
ROX
Permeabilized cellsHumanBlood cells
Platelet
Smith 2013 Biochem J2013Smith ME, Tippetts TS, Brassfield ES, Tucker BJ, Ockey A, Swensen AC, Anthonymuthu TS, Washburn TD, Kane DA, Prince JT, Bikman BT (2013) Mitochondrial fission mediates ceramide-induced metabolic disruption in skeletal muscle. Biochem J 456:427-39.LEAK
ROUTINE
OXPHOS
ETS
N
S
NS
ROX
Intact cells
Permeabilized tissue
MouseSkeletal muscle
Other cell lines
Pak 2013 Am J Respir Cell Mol Biol2013Pak O, Sommer N, Hoeres T, Bakr A, Waisbrod S, Sydykov A, Haag D, Esfandiary A, Kojonazarov B, Veit F, Fuchs B, Weisel FC, Hecker M, Schermuly RT, Grimminger F, Ghofrani HA, Seeger W, Weissmann N (2013) Mitochondrial hyperpolarization in pulmonary vascular remodeling - UCP2 deficiency as disease model. Am J Respir Cell Mol Biol 49:358-67.LEAK
ROUTINE
ETS
N
S
Intact cellsHuman
Rat
Lung;gill
Ceusters 2013 Mitochondrion2013Ceusters Justine D, Mouithys-Mickalad AA, Franck TJ, Derochette S, Vanderplasschen A, Deby-Dupont GP, Serteyn DA (2013) Effect of myeloperoxidase and anoxia/reoxygenation on mitochondrial respiratory function of cultured primary equine skeletal myoblasts. Mitochondrion 13:410-16.ETS
LEAK
OXPHOS
ROUTINE
Permeabilized cellsHorseSkeletal muscle
Ghozlan 2013 Thesis University of Calgary - Canada2013Ghozlan M (2013) The effect of myostatin on glucose metabolism and insulin sensitivity. Thesis University of Calgary - Canada 104pp.LEAK
ROUTINE
ETS
Intact cellsMouseSkeletal muscle
Liver
Other cell lines
Stier 2013 Front Zool2013Stier A, Bize P, Schull Q, Zoll J, Singh F, Geny B, Gros F, Royer C, Massemin S, Criscuolo F (2013) Avian erythrocytes have functional mitochondria, opening novel perspectives for birds as animal models in the study of ageing. Front Zool 10:33.ROUTINEPermeabilized cellsMouse
Birds
Blood cells
Chacko 2013 Lab Invest2013Chacko BK, Kramer PA, Ravi S, Johnson MS, Hardy RW, Ballinger SW, Darley-Usmar VM (2013) Methods for defining distinct bioenergetic profiles in platelets, lymphocytes, monocytes, and neutrophils, and the oxidative burst from human blood. Lab Invest 93:690-700.LEAK
ROUTINE
ETS
ROXIntact cellsHumanBlood cells
Other cell lines
Lymphocyte
Platelet
Santidrian 2013 J Clin Invest2013Santidrian AF, Matsuno-Yagi A, Ritland M, Seo BB, Leboeuf SE, Gay LJ, Yagi T, Felding-Habermann B (2013) Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression. J Clin Invest 123:1068-81.ROUTINEIntact cellsHumanGenital
Leadsham 2013 Cell Metab2013Leadsham JE, Sanders G, Giannaki S, Bastow EL, Hutton R, Naeimi WR, Breitenbach M, Gourlay CW (2013) Loss of cytochrome c oxidase promotes RAS-dependent ROS production from the ER resident NADPH oxidase, Yno1p, in yeast. Cell Metab 18:279-86.ROUTINEIntact cellsSaccharomyces cerevisiae
Hals 2013 J Diabetes Res2013Hals IK, Rokstad AM, Strand BL, Oberholzer J, Grill V (2013) Alginate microencapsulation of human islets does not increase susceptibility to acute hypoxia. J Diabetes Res 2013:374925.ROUTINE
ETS
N
ROX
Intact cellsHumanIslet cell;pancreas;thymus
Hirzel 2013 J Recept Signal Transduct Res2013Hirzel E, Lindinger PW, Maseneni S, Giese M, Rhein VV, Eckert A, Hoch M, Krähenbühl S, Eberle AN (2013) Differential modulation of ROS signals and other mitochondrial parameters by the antioxidants MitoQ, resveratrol and curcumin in human adipocytes. J Recept Signal Transduct Res 33:304-12.ETS
ROUTINE
N
NS
Permeabilized cellsHumanFat
Other cell lines
Constant-Urban 2013 Bioorg Med Chem Lett2013Constant-Urban C, Charif M, Goffin E, Van Heugen JC, Elmoualij B, Chiap P, Mouithys-Mickalad A, Serteyn D, Lebrun P, Pirotte B, De Tullio P (2013) Triphenylphosphonium salts of 1,2,4-benzothiadiazine 1,1-dioxides related to diazoxide targeting mitochondrial ATP-sensitive potassium channels. Bioorg Med Chem Lett 23:5878-81.LEAK
ROUTINE
ETS
RatOther cell lines
Petiz 2013 Thesis Universidade Federal do Parana - Brazil2013Petiz LL (2013) Efeitos da N-N’-difenil-4-metoxi-benzamidina sobre parâmetros do metabolismo energético em mitocôndrias e hepatócitos. Thesis Universidade Federal do Parana - Brazil 91pp.LEAK
ROUTINE
OXPHOS
NIntact cells
Isolated mitochondria
Liver
Dufour 2013 Appl Environ Microbiol2013Dufour V, Stahl M, Rosenfeld E, Stintzi A, Baysse C (2013) Insights into the mode of action of benzylisothiocyanate on Campylobacter jejuni. Appl Environ Microbiol 79:6958-68.ROUTINEIntact cellsEubacteria
Bociaga-Jasik 2013 Pharmacol Rep2013Bociąga-Jasik M, Polus A, Góralska J, Czech U, Gruca A, Sliwa A, Garlicki A, Mach T, Dembińska-Kieć A (2013) Metabolic effects of the HIV protease inhibitor – saquinavir in differentiating human preadipocytes. Pharmacol Rep 65:937-50.ROUTINEIntact cellsHumanFat
Other cell lines
Dufour 2013 Microbiology2013Dufour V, Li J, Flint A, Rosenfeld E, Rivoal K, Georgeault S, Alazzam B, Ermel G, Stintzi A, Bonnaure-Mallet M, Baysse C (2013) Inactivation of the LysR regulator Cj1000 of Campylobacter jejuni affects host colonisation and respiration. Microbiology 159:1165-78.ROUTINEIntact cellsEubacteria
Dickinson 2013 Cell Death Differ2013Dickinson A, Yeung KY, Donoghue J, Baker MJ, Kelly RDW, McKenzie M, Johns TG, St. John JC (2013) The regulation of mitochondrial DNA copy number in glioblastoma cells. Cell Death Differ 20:1644–53.LEAK
ROUTINE
ETS
ROXHumanNervous system
Other cell lines
Dickinson 2013 Thesis University of Warwick - Great Britain2013Dickinson A (2013) The role of mitochondrial DNA in tumorigenesis. Thesis University of Warwick - Great Britain 292pp.LEAK
ROUTINE
ETS
ROXIntact cellsHumanOther cell lines
Villarroel 2013 J Trauma Acute Care Surg2013Villarroel JP, Guan Y, Werlin E, Selak MA, Becker LB, Sims CA (2013) Hemorrhagic shock and resuscitation are associated with peripheral blood mononuclear cell mitochondrial dysfunction and immunosuppression. J Trauma Acute Care Surg 75:24-31.LEAK
ROUTINE
ETS
S
ROX
Intact cellsRatBlood cells
Lymphocyte
Ceusters 2013 Res Vet Sci2013Ceusters Justine D, Mouithys-Mickalad AA, Franck TJ, Deby-Dupont GP, Derochette S, Serteyn DA (2013) Effect of different kinds of anoxia/reoxygenation on the mitochondrial function and the free radicals production of cultured primary equine skeletal myoblasts. Res Vet Sci 95:870-8.ROUTINENIntact cellsHorseSkeletal muscle
Kushnareva 2013 Cell Death Differ2013Kushnareva YE, Gerencser AA, Bossy B, Ju WK, White AD, Waggoner J, Ellisman MH, Perkins G, Bossy-Wetzel E (2013) Loss of OPA1 disturbs cellular calcium homeostasis and sensitizes for excitotoxicity. Cell Death Differ 20:353-65.LEAK
ROUTINE
OXPHOS
ETS
N
S
Intact cells
Permeabilized cells
HumanEndothelial;epithelial;mesothelial cell
HeLa
Huai 2013 J Cell Sci2013Huai J, Vögtle FN, Jöckel L, Li Y, Kiefer T, Ricci JE, Borner C (2013) TNFα-induced lysosomal membrane permeability (LMP) is downstream of MOMP and triggered by caspase-mediated p75 cleavage and ROS formation. J Cell Sci 126:4015-25.ROUTINEIntact cellsHuman
Mouse
HeLa
Fibroblast
Sjoevall 2013 Mitochondrion2013Sjövall F, Ehinger JK, Marelsson SE, Morota S, Asander Frostner E, Uchino H, Lundgren J, Arnbjörnsson E, Hansson Magnus J, Fellman V, Elmér E (2013) Mitochondrial respiration in human viable platelets - methodology and influence of gender, age and storage. Mitochondrion 13:7-14.LEAK
ROUTINE
OXPHOS
ETS
N
ROX
Intact cells
Permeabilized cells
HumanBlood cells
Platelet
Hall 2013 Biochim Biophys Acta2013Hall A, Larsen AK, Parhamifar L, Meyle KD, Wu LP, Moghimi SM (2013) High-resolution respirometry analysis of polyethylenimine-mediated mitochondrial energy crisis and cellular stress: Mitochondrial proton leak and inhibition of the electron transport system. Biochim Biophys Acta 1827:1213-25.LEAK
ROUTINE
OXPHOS
ETS
N
S
CIV
ROX
Isolated mitochondria
SMP
MouseLiver
Other cell lines
Bhattacharyya 2013 PLoS One2013Bhattacharyya S, Saha S, Giri K, Lanza IR, Nair KS, Jennings NB, Rodriguez-Aguayo C, Lopez-Berestein G, Basal E, Weaver AL, Visscher DW, Cliby W, Sood AK, Bhattacharya R, Mukherjee P (2013) Cystathionine Beta-Synthase (CBS) contributes to advanced ovarian cancer progression and drug resistance. PLoS One 8:e79167.ROUTINE
ETS
Intact cellsHumanGenital
Other cell lines
Basal respiration2013Gnaiger E (2013) Basal respiration in physiology, cellular bioenergetics and mitochondrial physiology. Mitochondr Physiol Network 2013-07-07.LEAK
ROUTINE
Intact cells
Permeabilized cells
Permeabilized tissue
Homogenate
Isolated mitochondria
Volejnikova 2013 FEMS Yeast Res2013Volejníková A, Hlousková J, Sigler K, Pichová A (2013) Vital mitochondrial functions show profound changes during yeast culture ageing. FEMS Yeast Res 13:7-15.ROUTINE
ETS
Intact cells
Isolated mitochondria
Saccharomyces cerevisiae
Fungi
Mathieu 2013 J Med Chem2013Mathieu V, Van Den Berge E, Ceusters Justine D, Konopka T, Cops A, Bruyère C, Pirker C, Berger W, Trieu-Van T, Serteyn D, Kiss R, Robiette R (2013) New 5-Aryl-1H-imidazoles display in vitro antitumor activity against apoptosis-resistant cancer models, including melanomas, through mitochondrial targeting. J Med Chem 56:6626-37.ROUTINEIntact cellsHumanEndothelial;epithelial;mesothelial cell
Other cell lines
Henriques 2013 Thesis Universidade de Coimbra - Portugal2013Henriques TAF (2013) High-resolution respirometry for metabolic profiling of acute rat hippocampal slices. Thesis Universidade de Coimbra - Portugal 38pp.LEAK
ROUTINE
ETS
N
S
ROX
Intact cellsRatNervous system
Sjoevall 2013 Crit Care2013Sjoevall F, Morota S, Persson J, Hansson Magnus J, Elmer E (2013) Patients with sepsis exhibit increased mitochondrial respiratory capacity in peripheral blood immune cells. Crit Care 17:R152.LEAK
ROUTINE
OXPHOS
ETS
N
S
CIV
NS
ROX
Intact cells
Permeabilized cells
HumanBlood cells
Sjövall 2013 Thesis Lund University - Sweden2013Sjövall F (2013) Mitochondrial function in sepsis - temporal evolvement of respiratory capacity in human blood cells. Thesis Lund University - Sweden 83pp.LEAK
ROUTINE
OXPHOS
ETS
N
S
ROX
Intact cells
Permeabilized cells
HumanBlood cells
Platelet
Vijgen 2013 J Clin Endocrinol Metab2013Vijgen GH, Sparks LM, Bouvy ND, Schaart G, Hoeks J, van Marken Lichtenbelt WD, Schrauwen P (2013) Increased oxygen consumption in human adipose tissue from the "brown adipose tissue" region. J Clin Endocrinol Metab 98:E1230-4.ETS
LEAK
ROUTINE
Permeabilized tissueHumanFat
Hroudova 2013 Mitochondrion2013Hroudová J, Fišar Z, Kitzlerová E, Zvěřová M, Raboch J (2013) Mitochondrial respiration in blood platelets of depressive patients. Mitochondrion 13:795-800.LEAK
ROUTINE
OXPHOS
ETS
N
S
NS
ROX
Intact cells
Permeabilized cells
HumanBlood cells
Platelet
Segalés 2013 Am J Physiol Endocrinol Metab2013Segalés J, Paz JC, Hernández-Alvarez MI, Sala D, Muñoz JP, Noguera E, Pich S, Palacín M, Enríquez JA, Zorzano A (2013) A form of mitofusin 2 (Mfn2) lacking the transmembrane domains and the COOH-terminal end stimulates metabolism in muscle and liver cells. Am J Physiol Endocrinol Metab 305:1208-21.LEAK
ROUTINE
OXPHOS
ETS
NIntact cells
Permeabilized tissue
MouseSkeletal muscle
Liver
Other cell lines
Kenwood 2013 Mol Metab2013Kenwood BM, Weaver JL, Bajwa A, Poon IK, Byrne FL, Murrow BA, Calderone JA, Huang L, Divakaruni AS, Tomsig JL, Okabe K, Lo RH, Cameron Coleman G, Columbus L, Yan Z, Saucerman JJ, Smith JS, Holmes JW, Lynch KR, Ravichandran KS, Uchiyama S, Santos WL, Rogers GW, Okusa MD, Bayliss DA, Hoehn KL (2013) Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane. Mol Metab 3:114-23.ROUTINE
ETS
Intact organism
Intact cells
Mouse
Bresciani Martins de Andrade P 2013 J Bioenerg Biomembr2013Bresciani Martins de Andrade P, Glaser V, da Luz Scheffer D, de Paula Ferreira PM, Wannmacher CM, Farina M, de Oliveira PA, Prediger RD, Latini A (2013) Platelet oxygen consumption as a peripheral blood marker of brain energetics in a mouse model of severe neurotoxicity. J Bioenerg Biomembr 45:449-57.ROUTINE
ETS
MouseBlood cells
Platelet
Kettunen 2013 Thesis University of Applied Sciences - Turku2013Kettunen J (2013) Ruskean rasvan hapenkulutuksen mittaaminen. Thesis University of Applied Sciences - Turku pp106.ROUTINEIntact cellsMouseFat
Karamercan 2013 Shock2013Karamercan MA, Weiss SL, Villarroel JP, Guan Y, Werlin E, Figueredo R, Becker LB, Sims C (2013) Can peripheral blood mononuclear cells be used as a proxy for mitochondrial dysfunction in vital organs during hemorrhagic shock and resuscitation? Shock 40:476-84.LEAK
ROUTINE
OXPHOS
ETS
N
S
CIV
Intact cells
Isolated mitochondria
RatHeart
Liver
Kidney
Blood cells
Lymphocyte
Gottfried 2013 PLoS One2013Gottfried E, Lang SA, Renner K, Bosserhoff A, Gronwald W, Rehli M, Einhell S, Gedig I, Singer K, Seilbeck A, Mackensen A, Grauer O, Hau P, Dettmer K, Andreesen R, Oefner PJ, Kreutz M (2013) New aspects of an old drug - Diclofenac targets MYC and glucose metabolism in tumor cells. PLoS One 8:e66987.LEAK
ROUTINE
ETS
Intact cellsHuman
Mouse
Endothelial;epithelial;mesothelial cell
Blood cells
Other cell lines
Lymphocyte
Zobi 2012 Dalton Trans2012Zobi F, Blacque O, Jacobs RA, Schaub MC, Bogdanova AY (2012) 17 e- rhenium dicarbonyl CO-releasing molecules on a cobalamin scaffold for biological application. Dalton Trans 41:370-8.ROUTINEPermeabilized cellsRatHeart
Quoilin 2012 Biochem Biophys Res Commun2012Quoilin C, Mouithys-Mickalad A, Duranteau J, Gallez B, Hoebeke M (2012) Endotoxin-induced basal respiration alterations of renal HK-2 cells: A sign of pathologic metabolism down-regulation. Biochem Biophys Res Commun 423:350-54.ROUTINEIntact cellsEndothelial;epithelial;mesothelial cell
Other cell lines
Boyle 2012 Brain Res2012Boyle JP, Hettiarachchi NT, Wilkinson JA, Pearson HA, Scragg JL, Lendon C, Al-Owais MM, Kim CB, Myers DM, Warburton P, Peers C (2012) Cellular consequences of the expression of Alzheimer's disease-causing presenilin 1 mutations in human neuroblastoma (SH-SY5Y) cells. Brain Res 1443:75-88.ROUTINEIntact cellsHumanNeuroblastoma
Hughey 2012 Cell Regen (Lond)2012Hughey CC, Alfaro MP, Belke DD, Rottman JN, Young PP, Wasserman DH, Shearer J (2012) Increased oxygen consumption and OXPHOS potential in superhealer mesenchymal stem cells. Cell Regen (Lond) 1:3.LEAK
ROUTINE
OXPHOS
ETS
N
S
NS
ROX
Intact cells
Permeabilized cells
Mouse
Rat
Heart
Stem cells
Goo 2012 PLoS One2012Goo CK, Lim HY, Ho QS, Too HP, Clement MV, Wong KP (2012) PTEN/Akt signaling controls mitochondrial respiratory capacity through 4E-BP1. PLoS One 7:e45806.ETS
LEAK
ROUTINE
ROXIntact cellsMouseFibroblast
Pesta 2012 Methods Mol Biol2012
O2k-Protocols
Pesta D, Gnaiger E (2012) High-resolution respirometry. OXPHOS protocols for human cells and permeabilized fibres from small biopsies of human muscle. Methods Mol Biol 810:25-58.
ETS
LEAK
OXPHOS
ROUTINE
F
N
NS
ROX
S
Intact cells
Permeabilized cells
Permeabilized tissue
HumanFibroblast
HEK
HUVEC
Other cell lines
Skeletal muscle
Hirsch 2012 PloS One2012Hirsch A, Hahn D, Kempná P, Hofer G, Mullis PE, Nuoffer JM, Flück CE (2012) Role of AMP-activated protein kinase on steroid hormone biosynthesis in adrenal NCI-H295R cells. PLoS One 7:e30956.ETS
ROUTINE
N
NS
S
Intact cells
Permeabilized cells
Human
Pig
Other cell lines
Welchen 2012 Biochim Biophys Acta2012Welchen E, Hildebrandt TM, Lewejohann D, Gonzalez DH, Braun HP (2012) Lack of cytochrome c in Arabidopsis decreases stability of Complex IV and modifies redox metabolism without affecting Complexes I and III. Biochim Biophys Acta 1817:990-1001.ROUTINE
OXPHOS
S
ROX
Intact cells
Isolated mitochondria
Plants
Wu 2012 Cell2012Wu J, Boström P, Sparks LM, Ye L, Choi JH, Giang AH, Khandekar M, Virtanen KA, Nuutila P, Schaart G, Huang K, Tu H, van Marken Lichtenbelt WD, Hoeks J, Enerbäck S, Schrauwen P, Spiegelman BM (2012) Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell 150:366-76.ROUTINE
ETS
Intact cellsMouseFat
Albertini 2012 Aging (Albany NY)2012Albertini E, Kozieł R, Duerr A, Neuhaus M, Jansen-Duerr P (2012) Cystathionine beta synthase modulates senescence of human endothelial cells. Aging (Albany NY) 4:664-73.LEAK
ROUTINE
ETS
Intact cellsHumanEndothelial;epithelial;mesothelial cell
HUVEC
Stiburek 2012 Mol Biol Cell2012Stiburek L, Cesnekova J, Kostkova O, Fornuskova D, Vinsova K, Wenchich L, Houstek J, Zeman J (2012) YME1L controls the accumulation of respiratory chain subunits and is required for apoptotic resistance, cristae morphogenesis and cell proliferation. Mol Biol Cell 23: 1010-1023.ROUTINEHumanHEK
De Paula Martins 2012 Thesis Universidade Federal de Santa Catarina2012De Paula Martins R (2012) Altered mitochondrial ultrastructure, diminished content and energetics in the cerebral cortex from methylmercury-poisoned mice are prevented by diphenyl diselenide administration. Thesis Universidade Federal de Santa Catarina, Centro de Ciências Biológicas 104pp.LEAK
ROUTINE
ETS
Intact cellsMouseBlood cells
Platelet
Gomez-Duran 2012 Biochim Biophys Acta2012Gómez-Durán A, Pacheu-Grau D, Martínez-Romero I, López-Gallardo E, López-Pérez MJ, Montoya J, Ruiz-Pesini E (2012) Oxidative phosphorylation differences between mitochondrial DNA haplogroups modify the risk of Leber's hereditary optic neuropathy. Biochim Biophys Acta 1822:1216-22.LEAK
ROUTINE
ETS
Intact cellsHumanBlood cells
Platelet
Sugimura 2012 J Reprod Dev2012Sugimura S, Matoba S, Hashiyada Y, Aikawa Y, Ohtake M, Matsuda H, Kobayashi S, Konishi K, Imai K. (2012) Oxidative phosphorylation-linked respiration in individual bovine oocytes. J Reprod Dev 58:636-41.LEAK
ROUTINE
ETS
Intact cellsBovinesGenital
Jose 2012 Thesis Université Victor Segalen Bordeaux - France2012Jose C (2012) Rôle des mitochondries dans la tumorigénèse: implications pour le traitement du cancer. Thesis Université Victor Segalen Bordeaux - France 272pp.LEAK
ROUTINE
OXPHOS
ETS
N
S
Intact cells
Permeabilized cells
HumanOther cell lines
HeLa
Jung 2012 J Med Food2012Jung HY, Lee AN, Song TJ, An HS, Kim YH, Kim KD, Kim IB, Kim KS, Han BS, Kim CH, Kim KS, Kim JB (2012) Korean mistletoe (Viscum album coloratum) extract improves endurance capacity in mice by stimulating mitochondrial activity. J Med Food 15:621-8.ROUTINEIntact cellsMouseLiver
Kidney
Mebarek 2011 Global Change2011Mebarek L, Denis M, Grégori G (2011) A new method to measure prokaryote respiration at the single cell level by flow cytometry. Global Change: Mankind-Marine Environment Interactions. Part 5: 269-271.ROUTINEIntact cellsEubacteria
Viader 2011 J Neurosci2011Viader A, Golden JP, Baloh RH, Schmidt RE, Hunter DA, Milbrandt J (2011) Schwann cell mitochondrial metabolism supports long-term axonal survival and peripheral nerve function. J Neurosci 31:10128-40.ROUTINEIntact cellsMouseNervous system
Kristiansen 2011 J Biol Chem2011Kristiansen G, Hu J, Wichmann D, Stiehl DP, Rose M, Gerhardt J, Bohnert A, ten Haaf A, Moch H, Raleigh J, Varia MA, Subarsky P, Scandurra FM, Gnaiger E, Gleixner E, Bicker A, Gassmann M, Hankeln T, Dahl E, Gorr TA (2011) Endogenous myoglobin in breast cancer is hypoxia-inducible by alternate transcription and functions to impair mitochondrial activity: a role in tumor suppression? J Biol Chem 286:43417-28.ROUTINEIntact cellsHumanGenital
Other cell lines
Eberhart 2011 Biochim Biophys Acta2011Eberhart K, Rainer J, Bindreither D, Ritter I, Gnaiger E, Kofler R, Oefner PJ, Renner K (2011) Glucocorticoid-induced alterations in mitochondrial membrane properties and respiration in childhood acute lymphoblastic leukemia. Biochim Biophys Acta 1807:719-25.ETS
LEAK
OXPHOS
ROUTINE
N
NS
S
Intact cells
Permeabilized cells
HumanBlood cells
Ye 2011 J Biol Chem2011Ye F, Lemieux H, Hoppel CL, Hanson RW, Hakimi P, Croniger CM, Puchowicz M, Anderson VE, Fujioka H, Stavnezer E (2011) Peroxisome proliferator-activated receptor γ (PPARγ) mediates a Ski-induced shift from glycolysis to oxidative energy metabolism. J Biol Chem 286:40013-24.ROUTINEIntact cellsChickenFibroblast
Sebollela 2010 Neurotox Res2010Sebollela A, Freitas-Corrêa L, Oliveira FF, Mendes CT, Wasilewska-Sampaio AP, Camacho-Pereira J, Galina A, Brentani H, Passetti F, De Felice FG, Dias-Neto E, Ferreira ST (2010) Expression profile of rat hippocampal neurons treated with the neuroprotective compound 2,4-dinitrophenol: Up-regulation of cAMP signaling genes. Neurotox Res 18:112-23.ROUTINEIntact cellsRatNervous system
Sommer 2010 Eur Respir J2010Sommer N, Pak O, Schörner S, Derfuss T, Krug A, Gnaiger E, Ghofrani HA, Schermuly RT, Huckstorf C, Seeger W, Grimminger F, Weissmann N (2010) Mitochondrial cytochrome redox states and respiration in acute pulmonary oxygen sensing. Eur Respir J 36:1056-66.ROUTINE
ETS
Intact cellsHumanLung;gill
Endothelial;epithelial;mesothelial cell
Lagoutte 2010 Biochim Biophys Acta2010Lagoutte E, Mimoun S, Andriamihaja M, Chaumontet C, Blachier F, Bouillaud F (2010) Oxidation of hydrogen sulfide remains a priority in mammalian cells and causes reverse electron transfer in colonocytes. Biochim Biophys Acta 1797:1500-11.LEAK
ROUTINE
Other combinationsIsolated mitochondriaMouseHeart
Nervous system
Liver
Kidney
Aguirre 2010 Biochim Biophys Acta2010Aguirre E, Rodríguez-Juárez F, Bellelli A, Gnaiger E, Cadenas S (2010) Kinetic model of the inhibition of respiration by endogenous nitric oxide in intact cells. Biochim Biophys Acta 1797:557-65.LEAK
ROUTINE
ETS
ROXIntact cells
Enzyme
Oxidase;biochemical oxidation
HEK
Remels 2010 Mol Cell Endocrinol2010Remels AH, Langen RC, Schrauwen P, Schaart G, Schols AM, Gosker HR (2010) Regulation of mitochondrial biogenesis during myogenesis. Mol Cell Endocrinol 315:113-20.ROUTINE
OXPHOS
ETS
FPermeabilized cellsMouse
Rat
Skeletal muscle
Other cell lines
Sjoevall 2010 Crit Care2010Sjoevall F, Morota S, Hansson Magnus J, Friberg H, Gnaiger E, Elmer E (2010) Temporal increase of platelet mitochondrial respiration is negatively associated with clinical outcome in patients with sepsis. Crit Care 14:R214.LEAK
ROUTINE
OXPHOS
ETS
N
S
NS
ROX
Intact cells
Permeabilized cells
HumanBlood cells
Platelet
Dikov 2010 Exp Gerontol2010Dikov D, Aulbach A, Muster B, Dröse S, Jendrach M, Bereiter-Hahn J (2010) Do UCP2 and mild uncoupling improve longevity? Exp Gerontol 45:586-95.LEAK
ROUTINE
ETS
Intact cellsHeLa
Fibroblast
HUVEC
Gomez-Duran 2010 Hum Mol Genet2010Gómez-Durán A, Pacheu-Grau D, López-Gallardo E, Díez-Sánchez C, Montoya J, López-Pérez MJ, Ruiz-Pesini E (2010) Unmasking the causes of multifactorial disorders: OXPHOS differences between mitochondrial haplogroups. Hum Mol Genet 19:3343-53.LEAK
ROUTINE
ETS
Intact cellsHuman
Scandurra 2010 Adv Exp Med Biol2010Scandurra FM, Gnaiger E (2010) Cell respiration under hypoxia: facts and artefacts in mitochondrial oxygen kinetics. Adv Exp Med Biol 662:7-25.LEAK
ROUTINE
OXPHOS
ETS
Intact cells
Isolated mitochondria
MouseBlood cells
Esteves 2010 J Neurochem2010Esteves AR, Lu J, Rodova M, Onyango I, Lezi E, Dubinsky R, Lyons KE, Pahwa R, Burns JM, Cardoso SM, Swerdlow RH (2010) Mitochondrial respiration and respiration-associated proteins in cell lines created through Parkinson's subject mitochondrial transfer. J Neurochem 113:674-82.LEAK
ROUTINE
ETS
N
ROX
Intact cellsHumanBlood cells
Platelet
Smolkova 2010 J Bioenerg Biomembr2010Smolková K, Bellance N, Scandurra F, Génot E, Gnaiger E, Plecitá-Hlavatá L, Ježek P, Rossignol R (2010) Mitochondrial bioenergetic adaptations of breast cancer cells to aglycemia and hypoxia. J Bioenerg Biomembr 42:55-67.ROUTINE
OXPHOS
ETS
N
NS
Intact cellsHumanFibroblast
Carmona 2009 Int J Obes2009Carmona OMC, Amigó M, Barceló-Batllori S, Julià M, Esteban Y, Moreno S, Gomis R (2009) Dual effects of sodium tungstate on adipocyte biology: Inhibition of adipogenesis and stimulation of cellular oxygen consumption. Int J Obes 33:534-40.ROUTINEIntact cells
Eberhart 2009 Leukemia2009Eberhart K, Renner K, Ritter I, Kastenberger M, Singer K, Hellerbrand C, Kreutz M, Kofler R, Oefner PJ (2009) Low doses of 2-deoxy-glucose sensitize acute lymphoblastic leukemia cells to glucocorticoid-induced apoptosis. Leukemia 23:2167-70.LEAK
ROUTINE
ETS
ROXIntact cellsHumanBlood cells
Lymphocyte
Guachalla 2009 Aging (Albany NY)2009Guachalla LM, Ju Z, Koziel R, Figura G, Song Z, Fusser M, Epe B, Jansen-Dürr P, Rudolph KL (2009) SOD2 haploinsufficiency does not accelerate aging of telomere dysfunctional mice. Aging (Albany NY) 1:303-15.ROUTINEIntact cellsMouseNervous system
Bosworth 2009 Proc Natl Acad Sci U S A2009Bosworth CA, Toledo JC Jr, Zmijewski JW, Li Q, Lancaster JR (2009) Dinitrosyliron complexes and the mechanism(s) of cellular protein nitrosothiol formation from nitric oxide. Proc Natl Acad Sci U S A 106:4671-6.ROUTINEIntact cellsFungi
Iyer 2009 Mitochondrion2009Iyer S, Thomas R, Portell F, Dunham L, Quigley C, Bennett JP (2009) Recombinant mitochondrial transcription factor A with N-terminal mitochondrial transduction domain increases respiration and mitochondrial gene expression. Mitochondrion 9:196-203.ROUTINEHumanSkeletal muscle
Nervous system
Bredholt T 2009 Mol Cancer2009Bredholt T, Dimba EA, Hagland HR, Wergeland L, Skavland J, Fossan KO, Tronstad KJ, Johannessen AC, Vintermyr OK, Gjertsen BT (2009) Camptothecin and khat (Catha edulis Forsk.) induced distinct cell death phenotypes involving modulation of c-FLIPL, Mcl-1, procaspase-8 and mitochondrial function in acute myeloid leukemia cell lines. Mol Cancer 8:101.ROUTINEIntact cellsHumanBlood cells
Hoeks 2008 FEBS Lett2008Hoeks J, Briedé JJ, de Vogel J, Schaart G, Nabben M, Moonen-Kornips E, Hesselink MK, Schrauwen P (2008) Mitochondrial function, content and ROS production in rat skeletal muscle: Effect of high-fat feeding. FEBS Lett 582:510-16.ROUTINE
OXPHOS
ETS
F
NS
ROX
Isolated mitochondriaRatSkeletal muscle
Spacek 2008 Int J Biochem Cell Biol2008Spacek T, Santorová J, Zacharovová K, Berková Z, Hlavatá L, Saudek F, Jezek P (2008) Glucose-stimulated insulin secretion of insulinoma INS-1E cells is associated with elevation of both respiration and mitochondrial membrane potential. Int J Biochem Cell Biol 40:1522-35.LEAK
ROUTINE
ETS
ROXIntact cellsRatIslet cell;pancreas;thymus
Other cell lines
Gnaiger 2008 POS2008
O2k-Protocols contents
Gnaiger E (2008) Polarographic oxygen sensors, the oxygraph and high-resolution respirometry to assess mitochondrial function. In: Mitochondrial Dysfunction in Drug-Induced Toxicity (Dykens JA, Will Y, eds) John Wiley & Sons, Inc, Hoboken, NJ:327-52.
LEAK
ROUTINE
ETS
ROXIntact cells
Permeabilized cells
Permeabilized tissue
MouseBlood cells
Franciso 2007 Eur J Pharmacol2007Franciso R, Perez-Tomas R, Gimenez-Bonafe P, Soto-Cerrato V, Gimenez-Xavier P, Santiago A (2007) Mechanisms of prodigiosin cytotoxicity in human neuroblastoma cell lines. Eur J Pharmacol 572:111-9.ROUTINEIntact cellsHumanNeuroblastoma
Rodriguez-Juarez 2007 Biochem J2007Rodriguez-Juarez F, Aguirre E, Cadenas S (2007) Relative sensitivity of soluble guanylate cyclase and mitochondrial respiration to endogenous nitric oxide at physiological oxygen concentration. Biochem J 405:223-31.ROUTINEIntact cellsRatFibroblast
Stephenne 2007 Cell Transplant2007Stéphenne X, Najimi M, Ngoc DK, Smets F, Hue L, Guigas B, Sokal EM (2007) Cryopreservation of human hepatocytes alters the mitochondrial respiratory chain complex 1. Cell Transplant 16:409-19.ROUTINE
ETS
NIntact cells
Permeabilized cells
Human
Mouse
Liver
Schober 2007 Theriogenology2007Schober D, Aurich C, Nohl H, Gille L (2007) Influence of cryopreservation on mitochondrial functions in equine spermatozoa. Theriogenology 68:745-54.ROUTINE
ETS
Intact cellsHorse
Cadenas 2006 Biochim Biophys Acta2006Aguirre E, Rodriguez-Juarez F, Gnaiger E, Cadenas S (2006) Measurement of the control of cellular respiration by nitric oxide under normoxia and hypoxia: instrumental comparison including high-resolution respirometry. Biochim Biophys Acta, EBEC Short Reports Suppl 14:136-7.ROUTINEIntact cells
Enzyme
Oxidase;biochemical oxidation
HumanHEK
Huetter 2006 Exp Gerontol2006Hütter E, Unterluggauer H, Garedew A, Jansen-Dürr P, Gnaiger E (2006) High-resolution respirometry - a modern tool in aging research. Exp Gerontol 41:103-9.ROUTINEIntact cellsHumanEndothelial;epithelial;mesothelial cell
HUVEC
Stadlmann 2006 Cell Biochem Biophys2006Stadlmann S, Renner K, Pollheimer J, Moser PL, Zeimet AG, Offner FA, Gnaiger E (2006) Preserved coupling of oxydative phosphorylation but decreased mitochondrial respiratory capacity in IL-1ß treated human peritoneal mesothelial cells. Cell Biochem Biophys 44:179-86.ROUTINE
ETS
Intact cellsHumanEndothelial;epithelial;mesothelial cell
Hervouet 2006 Biochem Biophys Res Commun2006Hervouet E, Pecina P, Demont J, Vojtíšková A, Simonnet H, Houštek J, Godinot C (2006) Inhibition of cytochrome c oxidase subunit 4 precursor processing by the hypoxia mimic cobalt chloride. Biochem Biophys Res Commun 344:1086-93.ROUTINEIntact cellsHuman
Saccharomyces cerevisiae
Fungi
Pecina 2004 Am J Physiol Cell Physiol2004Pecina P, Gnaiger E, Zeman J, Pronicka E, Houstek J (2004) Decreased affinity to oxygen of cytochrome c oxidase in Leigh syndrome caused by SURF1 mutations. Am J Physiol Cell Physiol 287:C1384-8.ROUTINEIntact cellsHumanFibroblast
Manzl 2004 J Exp Zool A2004Manzl C, Krumschnabel G, Schwarzbaum PJ, Chabicovsky M, Dallinger R (2004) Intracellular pH regulation in isolated hepatopancreas cells from the Roman snail (Helix pomatia). J Exp Zool A 301:75-84.ROUTINEIntact cellsMolluscs
Manzl 2004 Comp Biochem Physiol C Toxicol Pharmacol2004Manzl C, Krumschnabel G, Schwarzbaum PJ, Dallinger R (2004) Acute toxicity of cadmium and copper in hepatopancreas cells from the Roman snail (Helix pomatia). Comp Biochem Physiol C Toxicol Pharmacol 138:45-52.ROUTINEMolluscs
Krumschnabel 2004 Aquat Toxicol2004Krumschnabel G, Nawaz M (2004) Acute toxicity of hexavalent chromium in isolated teleost hepatocytes. Aquat Toxicol 70:159-167.ROUTINEIntact cellsFishesLiver
Huetter 2004 Biochem J2004Hütter E, Renner K, Pfister G, Stöckl P, Jansen-Dürr P, Gnaiger E (2004) Senescence-associated changes in respiration and oxidative phosphorylation in primary human fibroblasts. Biochem J 380:919-28.LEAK
ROUTINE
ETS
Intact cellsHumanFibroblast
Rissanen 2003 Aquat Toxicol2003Rissanen E, Krumschnabel G, Nikinmaa M (2003) Dehydroabietic acid, a major component of wood industry effluents, interferes with cellular energetics in rainbow trout hepatocytes. Aquat Toxicol 62:45-53.ROUTINEIntact cellsFishesLiver
Kalbacova 2003 Cytometry2003Kalbácová M, Vrbacký M, Drahota Z, Melková Z (2003) Comparison of the effect of mitochondrial inhibitors on mitochondrial membrane potential in two different cell lines using flow cytometry and spectrofluorometry. Cytometry 52A:110-6.ROUTINEIntact cellsOther cell lines
Gnaiger 2003 Adv Exp Med Biol2003Gnaiger E (2003) Oxygen conformance of cellular respiration. A perspective of mitochondrial physiology. Adv Exp Med Biol 543:39-55.ROUTINE
OXPHOS
N
ROX
Intact cells
Permeabilized cells
Permeabilized tissue
Isolated mitochondria
Oxidase;biochemical oxidation
Human
Rat
Heart
Liver
Endothelial;epithelial;mesothelial cell
Fibroblast
Vrbacky 2003 Physiol Res2003Vrbacký M, Krijt J, Drahota Z, Mĕlková Z (2003) Inhibitory effects of Bcl-2 on mitochondrial respiration. Physiol Res 52:545-54.ROUTINE
OXPHOS
ETS
N
S
Intact cells
Permeabilized cells
Human
Other mammals
Endothelial;epithelial;mesothelial cell
Other cell lines
HeLa
Hollis 2003 Biochim Biophys Acta2003Hollis VS, Palacios-Callender M, Springett RJ, Delpy DT, Moncada S (2003) Monitoring cytochrome redox changes in the mitochondria of intact cells using multi-wavelength visible light spectroscopy. Biochim Biophys Acta 1607:191-202.ROUTINEIntact cellsHumanBlood cells
Renner 2003 Biochim Biophys Acta2003Renner K, Amberger A, Konwalinka G, Gnaiger E (2003) Changes of mitochondrial respiration, mitochondrial content and cell size after induction of apoptosis in leukemia cells. Biochim Biophys Acta 1642:115-23.ROUTINE
ETS
Intact cells
Permeabilized cells
Enzyme
Oxidase;biochemical oxidation
HumanBlood cells
Stadlmann 2002 Transplantation2002Stadlmann S, Rieger G, Amberger A, Kuznetsov AV, Margreiter R, Gnaiger E (2002) H2O2-mediated oxidative stress versus cold ischemia-reperfusion: mitochondrial respiratory defects in cultured human endothelial cells. Transplantation 74:1800-3.LEAK
ROUTINE
OXPHOS
N
S
CIV
ROX
Intact cells
Permeabilized cells
HumanEndothelial;epithelial;mesothelial cell
Huetter 2002 Mol Biol Rep2002Hütter E, Renner K, Jansen-Dürr P, Gnaiger E (2002) Biphasic oxygen kinetics of cellular respiration and linear oxygen dependence of antimycin A inhibited oxygen consumption. Mol Biol Rep 29:83-7.ROUTINEROXIntact cellsHumanFibroblast
Renner 2002 Mol Biol Rep2002Renner K, Kofler R, Gnaiger E (2002) Mitochondrial function in glucocorticoid triggered T-ALL cells with transgenic Bcl-2 expression. Mol Biol Rep 29:97-101.ROUTINEIntact cellsHumanBlood cells
Steininger 2002 J Antimicrob Chemother2002Steininger C, Allerberger F, Gnaiger E (2002) Clinical significance of inhibition kinetics in Streptococcus pyogenes in response to penicillin. J Antimicrob Chemother 50:517-23.ROUTINEIntact cellsEubacteria
Tomita 2001 Arthritis Rheum2001Tomita M, Sato EF, Nishikawa M, Yamano Y, Inoue M (2001) Nitric oxide regulates mitochondrial respiration and functions of articular chondrocytes. Arthritis Rheum 44:96-104.ROUTINEIntact cellsRabbit
Krumschnabel 2001 Gen Comp Endocrinol2001Krumschnabel G, Manzl C, Schwarzbaum PJ (2001) Metabolic responses to epinephrine stimulation in goldfish hepatocytes: evidence for the presence of alpha-adrenoceptors. Gen Comp Endocrinol 121:205-213.ROUTINEIntact cellsFishesLiver
Wieser 2001 Biochem J2001Wieser W, Krumschnabel G (2001) Hierarchies of ATP-consuming processes: direct compared with indirect measurements, and comparative aspects. Biochem J 355:389-395.ROUTINEIntact cellsHuman
Fishes
Liver
Krumschnabel 2001 J Exp Biol2001Krumschnabel G, Manzl C, Schwarzbaum PJ (2001) Regulation of intracellular pH in anoxia-tolerant and anoxia-intolerant teleost hepatocytes. J Exp Biol 204:3943-3951.ROUTINEIntact cellsFishesLiver
Johnson 2000 Arthritis Rheum2000Johnson K, Jung A, Murphy A, Andreyev A, Dykens J, Terkeltaub R (2000) Mitochondrial oxidative phosphorylation is a downstream regulator of nitric oxide effects on chondrocyte matrix synthesis and mineralization. Arthritis Rheum 43:1560-70.ROUTINEIntact cellsHuman
Roy Chowdhury 2000 Clin Chim Acta2000Roy Chowdhury SK, Drahota Z, Floryk D, Calda P, Houstek J (2000) Activities of mitochondrial oxidative phosphorylation enzymes in cultured amniocytes. Clin Chim Acta 298:157-73.LEAK
ROUTINE
OXPHOS
N
S
CIV
Permeabilized cellsHumanEndothelial;epithelial;mesothelial cell
Fibroblast
Gnaiger 2000 Transpl Int2000Gnaiger E, Kuznetsov AV, Rieger G, Amberger A, Fuchs A, Stadlmann S, Eberl T, Margreiter R (2000) Mitochondrial defects by intracellular calcium overload versus endothelial cold ischemia/reperfusion injury. Transpl Int 13:555-7.ROUTINE
OXPHOS
Intact cells
Permeabilized cells
Oxidase;biochemical oxidation
HumanEndothelial;epithelial;mesothelial cell
HUVEC
Guan 1999 Cytotechnol1999Guan YH, Kemp RB (1999) On-line heat flux measurements improve the culture medium for the growth and productivity of genetically engineered CHO cells. Cytotechnol 30:107-20.ROUTINEIntact cellsCHO
Steurer 1999 Transplant Proc1999Steurer W, Stadlmann S, Roberts K, Fischer M, Margreiter R, Gnaiger E (1999) Quality assessment of isolated pancreatic rat islets by high-resolution respirometry. Transplant Proc 31:650.ROUTINEIntact cellsRatIslet cell;pancreas;thymus
Hand 1999 Calorimetry1999Hand SC (1999) Calorimetric approaches to animal physiology and bioenergetics. In Kemp RB (ed) Handbook of Thermal Analysis and Calorimetry. Vol. 4: From Macromolecules to Man. Elsevier:469-510.ROUTINEIntact organism
Krumschnabel 1999 Comp Biochem Physiol C Pharmacol Toxicol Endocrinol1999Krumschnabel G, Schwarzbaum PJ, Wieser W (1999) Energetics of trout hepatocytes during A23187-induced disruption of Ca2+ homeostasis. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 124:187-195.ROUTINEIntact cellsFishesLiver
Guan 1999 ACT1999Guan YH, Kemp RB (1999) A model for the on-line scrutiny of metabolism: Its application to the changing nutritional demands of clutured animal cells. In Bernard A et al (eds) Animal cell technology: Products from cells, cells as products. Kluwer Academic Publ:131-3.ROUTINE
Guan 1999 J Biotechnol1999Guan YH, Kemp RB (1999) Detection of the changing substrate requirements of cultured animal cells by stoichiometric growth equations validated by enthalpy balances. J Biotechnol 69:95-114.ROUTINEIntact cellsCHO
Macrophage-derived
Gnaiger 1998 BTK-HRR1998Gnaiger E, Kuznetsov AV, Lassnig B, Fuchs A, Reck M, Renner K, Stadlmann S, Rieger G, Margreiter R (1998) High-resolution respirometry. Optimum permeabilization of the cell membrane by digitonin. In BioThermoKinetics in the Post Genomic Era (Larsson C, Pahlman I-L, Gustafsson L, eds) Chalmers Reproservice, Göteborg:89-95.ROUTINE
OXPHOS
SIntact cells
Permeabilized cells
HumanEndothelial;epithelial;mesothelial cell
HUVEC
Gnaiger 1998 J Exp Biol1998Gnaiger E, Lassnig B, Kuznetsov AV, Rieger G, Margreiter R (1998) Mitochondrial oxygen affinity, respiratory flux control, and excess capacity of cytochrome c oxidase. J Exp Biol 201:1129-39.ROUTINE
OXPHOS
N
S
CIV
Intact cells
Isolated mitochondria
Enzyme
Oxidase;biochemical oxidation
Human
Rat
Heart
Liver
Endothelial;epithelial;mesothelial cell
HUVEC
Villani 1998 J Biol Chem1998Villani G, Greco M, Papa S, Attardi G (1998) Low reserve of cytochrome c oxidase capacity in vivo in the respiratory chain of a variety of human cell types. J Biol Chem 273:31829-36.ROUTINE
ETS
N
S
Intact cells
Permeabilized cells
Other cell lines
Platelet
McClelland 1998 Proc Natl Acad Sci U S A1998McClelland GB, Hochachka PW, Weber JM (1998) Carbohydrate utilization during exercise after high-altitude acclimation: a new perspective. Proc Natl Acad Sci U S A 95:10288-93.ROUTINEIntact organismRat
Krumschnabel 1997 J Comp Physiol B1997Krumschnabel G, Biasi C, Schwarzbaum PJ, Wieser W (1997) Acute and chronic effects of temperature, and of nutritional state, on ion homeostasis and energy metabolism in teleost hepatocytes. J Comp Physiol B 167:280-6.ROUTINEIntact cellsFishesLiver
Kidane 1997 J Thermal Anal1997Kidane AH, Guan Y, Evans PM, Kaderbhai MA, Kemp RB (1997) Comparison of heat flux in wild-type and genetically-engineered Chinese hamster ovary cells. J Thermal Anal 49: 771-783.ROUTINEIntact cellsOther mammalsCHO
Steinlechner-Maran 1997 Transplantation1997Steinlechner-Maran R, Eberl T, Kunc M, Schröcksnadel H, Margreiter R, Gnaiger E (1997) Respiratory defect as an early event in preservation/reoxygenation injury in endothelial cells. Transplantation 63:136-42.ROUTINE
ETS
ROXIntact cellsHumanEndothelial;epithelial;mesothelial cell
HUVEC
Steinlechner-Maran 1996 Am J Physiol Cell Physiol1996Steinlechner-Maran R, Eberl T, Kunc M, Margreiter R, Gnaiger E (1996) Oxygen dependence of respiration in coupled and uncoupled endothelial cells. Am J Physiol Cell Physiol 271:C2053-61.ROUTINE
ETS
Intact cellsHumanEndothelial;epithelial;mesothelial cell
HUVEC
Krumschnabel 1996 Am J Physiol1996Krumschnabel G, Biasi C, Schwarzbaum PJ, Wieser W (1996) Membrane-metabolic coupling and ion homeostasis in anoxia-tolerant and anoxia-intolerant hepatocytes. Am J Physiol 270:R614-620.ROUTINEIntact cellsFishes
Gnaiger 1995 J Bioenerg Biomembr1995Gnaiger E, Steinlechner-Maran R, Méndez G, Eberl T, Margreiter R (1995) Control of mitochondrial and cellular respiration by oxygen. J Bioenerg Biomembr 27:583-96.LEAK
ROUTINE
OXPHOS
N
S
Intact cells
Isolated mitochondria
Human
Rat
Liver
Endothelial;epithelial;mesothelial cell
HUVEC
Kemp 1994 BTK-2261994
BTK1994
Kemp RB, Hoare S, Schmalfeldt M, Bridge ChMC, Evansa PM, Gnaiger E (1994) A thermochemical study of the producion of lactate by glutaminolysis and glycolysis in mouse macrophage hybridoma cells. In: What is Controlling Life? (Gnaiger E, Gellerich FN, Wyss M, eds) Modern Trends in BioThermoKinetics 3. Innsbruck Univ Press:226-31.
ROUTINEIntact cellsMouseMacrophage-derived
Eberl 1994 BTK-2881994
BTK1994
Eberl T, Steinlechner R, Salvenmoser W, Abendstein B, Rhomberg M, Schröcksnadel H, Schmid T, Gnaiger E, Margreiter R (1994) Endothelial cell cultures as a model for organ preservation studies. In: What is Controlling Life? (Gnaiger E, Gellerich FN, Wyss M, eds) Modern Trends in BioThermoKinetics 3. Innsbruck Univ Press:288-93.
ROUTINE
ETS
Intact cellsHumanEndothelial;epithelial;mesothelial cell
HUVEC
Krumschnabel 1994 Experientia1994Krumschnabel G, Wieser W (1994) Inhibition of the sodium pump does not cause a stoichiometric decrease of ATP-production in energy limited fish hepatocytes. Experientia 50:483-5.ROUTINEIntact cellsFishesLiver
Knoblechner 1994 BTK-2941994
BTK1994
Knoblechner A, Steinlechner R, Schirmer M, Gellerich FN, Margreiter R, Konwalinka G, Gnaiger E (1994) The effect of 2-chlorodeoxy-adenosine on endogenous respiration of a human lymphoma cell line (U-937). In: What is Controlling Life? (Gnaiger E, Gellerich FN, Wyss M, eds) Modern Trends in BioThermoKinetics 3. Innsbruck Univ Press:294-6.
ROUTINEIntact cellsHumanBlood cells
SteinlechnerMaran 1994 BTK-2831994
BTK1994
Steinlechner-Maran R, Eberl T, Margreiter R, Gnaiger E (1994) Oxygen dependence of cellular respiration in endothelial cells: A sensitive toxicological test. In: What is Controlling Life? (Gnaiger E, Gellerich FN, Wyss M, eds) Modern Trends in BioThermo-Kinetics 3. Innsbruck Univ Press:283-7.
ROUTINE
ETS
Intact cellsHumanEndothelial;epithelial;mesothelial cell
HUVEC
Krumschnabel 1994 J Exp Biol1994Krumschnabel G, Malle S, Schwarzbaum PJ, Wieser W (1994) Glycolytic function in goldfish hepatocytes at different temperatures: relevance for Na+ pump activity and protein synthesis. J Exp Biol 193:285-90.ROUTINEIntact cellsFishesLiver
Krumschnabel 1994 Physiol Zool1994Krumschnabel G, Schwarzbaum PJ, Wieser W (1994) Coupling of energy supply and energy demand in isolated goldfish hepatocytes. Physiol Zool 67:438-448.ROUTINEIntact cellsFishesLiver
Von Stockar 1993 Biochim Biophys Acta1993Von Stockar U, Gustafsson L, Larsson C, Marison I, Tissot P, Gnaiger E (1993) Thermodynamic considerations in constructing energy balances for cellular growth. Biochim Biophys Acta 1183:221-40.ROUTINEIntact organism
Intact cells
Fungi
Eubacteria
Doeller 1993 J Exp Zool1993Doeller JE, Kraus DW, Shick JM, Gnaiger E (1993) Heat flux, oxygen flux and mitochondrial redox state as a function of oxygen availability and ciliary beat activity in isolated gills of Mytilus edulis. J Exp Zool 265:1-8.ROUTINEIntact organMolluscsLung;gill
Gnaiger 1993 Verh Dtsch Zool Ges1993Gnaiger E (1993) Adaptations to winter hypoxia in a shallow alpine lake. Ecophysiological energetics of Cyclops abyssorum and rainbow trout. Verh Dtsch Zool Ges 86:43-65.ROUTINEIntact organismFishes
Crustaceans
Gnaiger 1993 Hypoxia1993Gnaiger E (1993) Efficiency and power strategies under hypoxia. Is low efficiency at high glycolytic ATP production a paradox? In: Surviving Hypoxia: Mechanisms of Control and Adaptation. Hochachka PW, Lutz PL, Sick T, Rosenthal M, Van den Thillart G (eds) CRC Press, Boca Raton, Ann Arbor, London, Tokyo:77-109.ROUTINEIntact organismHuman
Annelids
Skeletal muscle
Buck 1993 Am J Physiol Regul Integr Comp Physiol1993Buck LT, Hochachka PW, Schön A, Gnaiger E (1993) Microcalorimetric measurement of reversible metabolic suppression induced by anoxia in isolated hepatocytes. Am J Physiol Regul Integr Comp Physiol 265:R1014-9.LEAK
ROUTINE
Intact cellsReptilesLiver
Gnaiger 1993 Transitions1993Gnaiger E (1993) Homeostatic and microxic regulation of respiration in transitions to anaerobic metabolism. In: The vertebrate gas transport cascade: Adaptations to environment and mode of life. Bicudo JEPW (ed), CRC Press, Boca Raton, Ann Arbor, London, Tokyo:358-70.ROUTINEIntact organismReptiles
Fishes
Crustaceans
Annelids
Gnaiger 1992 Funct Ecol1992Gnaiger E (1992) Optimum efficiency of energy transformation and the evolution of catabolic pathways. Funct Ecol 6:234-41.ROUTINE
OXPHOS
Intact organism
Isolated mitochondria
RatLiver
Gnaiger 1991 Soc Exp Biol Seminar Series1991Gnaiger E (1991) Animal energetics at very low oxygen: Information from calorimetry and respirometry. In: Strategies for gas exchange and metabolism. Woakes R, Grieshaber M, Bridges CR (eds), Soc Exp Biol Seminar Series 44, Cambridge Univ Press, London:149-71.ROUTINEIntact organismAnnelids
Hand 1990 J Comp Physiol B1990Hand SC (1990) Heat dissipation during long-term anoxia in Artemia franciscana embryos: Identification and fate of metabolic fuels. J Comp Physiol B 160:357-63.ROUTINEIntact organismArtemia
Crustaceans
Doeller 1990 Thermochim Acta1990Doeller JE, Kraus DW, Gnaiger E, Shick JM (1990) Calorespirometry and spectrophotometry of the ciliated gill of the marine mussel Mytilus edulis. Thermochim Acta 172:171-8.ROUTINEIntact organMolluscsLung;gill
Gnaiger 1990 Biochim Biophys Acta1990Gnaiger E, Kemp RB (1990) Anaerobic metabolism in aerobic mammalian cells: information from the ratio of calorimetric heat flux and respirometric oxygen flux. Biochim Biophys Acta 1016:328-32.ROUTINEIntact cells
Gnaiger 1989 Soc Exp Biol Seminar Series1989Gnaiger E, Shick JM, Widdows J (1989) Metabolic microcalorimetry and respirometry of aquatic animals. In: Techniques in comparative respiratory physiology. An experimental approach. Bridges CR, Butler PJ (eds), Soc Exp Biol Seminar Series, Cambridge Univ Press, London:113-35.ROUTINEIntact organismCrustaceans
Annelids
Molluscs
Hand 1989 Thieme1989Hand SC, Gnaiger E (1989) Metabolic arrest in Artemia embryos quantified with microcalorimetric, respirometric and biochemical measurements. In: Energy transformations in cells and organisms. Wieser W, Gnaiger E (eds), Thieme, Stuttgart:155-62.ROUTINEIntact organismArtemia
Crustaceans
Hand 1988 Science1988Hand SC, Gnaiger E (1988) Anaerobic dormancy quantified in Artemia embryos: A calorimetric test of the control mechanism. Science 239:1425-7.ROUTINEIntact organismArtemia
Crustaceans
Gnaiger 1987 Physiol Zool1987Gnaiger E, Staudigl I (1987) Aerobic metabolism and physiological responses of aquatic oligochaetes to environmental anoxia. Heat dissipation, oxygen consumption, feeding and defecation. Physiol Zool 60:659-77.ROUTINEIntact organismAnnelids
Putzer 1985 Comp Biochem Physiol1985Putzer V, Gnaiger E, Lackner R (1985) Flexibility of anaerobic metabolism in aquatic oligochaetes (Tubifex sp.). Biochemical and calorimetric changes induced by a deproteinized hydrolysate of bovine blood. Comp Biochem Physiol 82A:965-70.ROUTINEIntact organismCrustaceans
Annelids
Gnaiger 1983 Sci Tools1983Gnaiger E (1983) Microcalorimetric monitoring of biological activities: Ecological and toxicological studies with aquatic animals. Sci Tools 30:21-6.ROUTINEIntact organism
Lomholt 1983 POS1983Lomholt JP, Johansen K (1983) The application of polarographic oxygen sensors for continuous assessment of gas exchange in aquatic animals. In: Polarographic Oxygen Sensors. Aquatic and Physiological Applications. Gnaiger E, Forstner H (eds), Springer, Berlin, Heidelberg, New York: 127-133. Springer 127-133.ROUTINEIntact organismFishes
Crustaceans
Gnaiger 1983 J Exp Zool1983Gnaiger E (1983) Heat dissipation and energetic efficiency in animal anoxibiosis. Economy contra power. J Exp Zool 228:471-90.ROUTINEIntact organismAnnelids
Molluscs
Skeletal muscle
Gnaiger 1983 Aquat Physiol Appl1983Gnaiger E (1983) The twin-flow microrespirometer and simultaneous calorimetry. In: Polarographic Oxygen Sensors. Aquatic and Physiological Applications. Gnaiger E, Forstner H (eds), Springer, Berlin, Heidelberg, New York:134-66.ROUTINEIntact organismFishes
Crustaceans
Annelids
Gnaiger 1983 POS1983Gnaiger E, Forstner H, eds (1983) Polarographic oxygen sensors. Aquatic and physiological applications. Springer, Berlin, Heidelberg, New York:370 pp.ROUTINE
OXPHOS
Intact organism
Intact cells
Isolated mitochondria
Chloroplasts
Human
Fishes
Crustaceans
Annelids
Molluscs
Plants
Eubacteria
Blood cells
Gnaiger 1980 FEBS Lett1980Gnaiger E (1980) Energetics of invertebrate anoxibiosis: direct calorimetry in aquatic oligochaetes. FEBS Lett 112:239-42.ROUTINEIntact organismAnnelids
Crabtree 1929 Biochem J1929Crabtree HG (1929) Observations on the carbohydrate metabolism of tumours. Biochem J 23:536–45.ROUTINEIntact cellsHuman
Rat


Publications in the MiPMap

Abstracts: ROUTINE

Sort in ascending/descending order by a click on one of the small symbols in squares below.
 YearReferenceCouplingPathwayPreparationOrganismTissue;cell
Volani 2016 Abstract Mito Xmas Meeting Innsbruck2016Effects of systemic iron perturbations on mitochondrial activity and on cellular metabolism in vivo.LEAK
ROUTINE
OXPHOS
ETS
N
S
HomogenateMouseLiver
Lamberti 2016 Abstract MitoFit Science Camp 20162016Development of a reference sample for HRR.LEAK
ROUTINE
OXPHOS
ETS
F
N
S
Gp
CIV
NS
Other combinations
ROX
HumanKidney
HEK
Doerrier 2016 Abstract MitoFit Science Camp 20162016Development of a SUIT reference protocol for OXPHOS analysis by high-resolution respirometry.LEAK
ROUTINE
OXPHOS
ETS
F
N
S
Gp
CIV
NS
ROX
Permeabilized cells
Permeabilized tissue
Homogenate
Isolated mitochondria
Human
Mouse
Heart
Blood cells
HEK
Platelet
Sumbalova 2016b Abstract MitoFit Science Camp 20162016Human blood cells: isolation and HRR.LEAK
ROUTINE
OXPHOS
ETS
F
N
S
Gp
CIV
NS
Other combinations
ROX
Intact cells
Permeabilized cells
HumanBlood cells
Lymphocyte
Platelet
Gnaiger 2016 Abstract SFRR Australasia 20162016Facts and artefacts in measurements of H2O2 production under hypoxia.ROUTINEIntact cellsSaccharomyces cerevisiae
Weber 2016 Abstract Mito Xmas Meeting Innsbruck2016Loss of PTEN in prostate cancer cells leads to a switch to succinate-mediated mitochondrial respiration associated with increased expression of NaDC3 and HIF-1alpha.ROUTINEN
NS
Intact cells
Permeabilized cells
Human
Mouse
Genital
Rutkai 2015 Abstract MiPschool Greenville 20152015Sex-differences in mitochondrial respiration is mediated by nitric oxide in rat cerebral arteries.LEAK
ROUTINE
ETS
RatEndothelial;epithelial;mesothelial cell
Laner 2015 Abstract MiPschool Cape Town 20152015The OROBOROS Oxygraph-2k for high-resolution respirometry and O2k-Fluorometry: a new quality in OXPHOS analysis.LEAK
ROUTINE
OXPHOS
ETS
N
S
NS
Intact cells
Isolated mitochondria
Mouse
Saccharomyces cerevisiae
Heart
Hoppel 2015 Abstract MiP20152015Effects of ultramarathon performance on mitochondrial respiration in human platelets.ROUTINE
OXPHOS
ETS
N
S
NS
Permeabilized cellsHumanBlood cells
Platelet
Gnaiger 2015 Abstract MiPschool Cape Town 2015 II2015On coupling control of mitochondrial respiration. What is wrong with the RCR?LEAK
ROUTINE
OXPHOS
ETS
N
S
ROX
Gnaiger 2015 Abstract MiP20152015Mitochondrial function of cyropreserved HEK 293T cells: development of a reference sample for high-resolution respirometry.LEAK
ROUTINE
OXPHOS
ETS
N
S
NS
Intact cells
Permeabilized cells
HumanHEK
Mussulini 2015 Abstract MiPschool London2015Changes of brain substrates preference and metabolism during seizure induced by pentylenetetrazole in adult zebrafish.ETS
ROUTINE
N
S
Intact organZebrafishNervous system
Van Dyk 2015 Abstract MiPschool Cape Town 20152015Optimization of selected cell lines for use on the Seahorse extracellular flux analyzer.LEAK
ROUTINE
ETS
N
ROX
Isolated mitochondriaHumanOther cell lines
Fibroblast
Karabatsiakis 2015 Abstract MiP20152015Mitochondrial respiration of peripheral blood mononuclear cells in patients with borderline personality disorder.LEAK
ROUTINE
OXPHOS
ETS
ROXHumanBlood cells
Nuskova 2015 Abstract MiPschool London 20152015Insufficient energy provision or increased oxidative stress – what matters more in ATP synthase deficiencies?ROUTINE
OXPHOS
HumanHEK
Smenes 2015 Abstract IOC1002015Smenes BT, Baekkerud FH, Hassel E, Wohlwend M, Slagsvold KH, Rognmo O, Wahba A (2015) Mitochondrial function in patients exercising prior to coronary surgery – A single blinded randomized controlled trial. Mitochondr Physiol Network 20.01.LEAK
ROUTINE
ETS
N
S
HumanSkeletal muscle
Rohlena 2015 Abstract MiP20152015Ubiquinone-binding site mutagenesis reveals the role of mitochondrial complex II in cell death initiation.ROUTINE
OXPHOS
ETS
S
ROX
Permeabilized cells
Isolated mitochondria
HumanOther cell lines
Dyrstad 2015 Abstract MiPschool London 20152015Activation of epithelial to mesenchymal transition (EMT) regulates stemness and metabolic reprogramming in mammary epithelial cells.LEAK
ROUTINE
ETS
N
ROX
HumanEndothelial;epithelial;mesothelial cell
Other cell lines
Gnaiger 2015 Abstract MiPschool Cape Town 20152015The functional design of the electron transfer system: substrate control of mitochondrial respiration.LEAK
ROUTINE
OXPHOS
ETS
N
S
NS
Permeabilized cells
Permeabilized tissue
Homogenate
Isolated mitochondria
Volani 2015 Abstract IOC1062015Volani C, Haschka D, Demetz E, Doerrier C, Gnaiger E, Weiss G (2015) Determination of mitochondrial respiration in peripheral blood mononuclear cells. Mitochondr Physiol Network 20.10.ROUTINE
OXPHOS
ETS
N
S
Intact cells
Homogenate
Human
Mouse
Heart
Liver
Blood cells
Lymphocyte
Laner 2014 Abstract MiP20142014Cytochrome c flux control factor as a quality criterion in respiratory OXPHOS analysis in canine permeabilized fibres.LEAK
ROUTINE
OXPHOS
ETS
N
NS
Permeabilized tissueDogSkeletal muscle
Eggimann 2014 Abstract MiP20142014Adaptation to nutrient availability in human fibroblasts with mitochondrial dysfunction: the role of sirtuins.ROUTINEIntact cellsHumanFibroblast
Karabatsiakis 2014 Abstract IOC962014Karabatsiakis A (2014) Consequences of depression on respiratory activity in peripheral blood mononuclear cells. Mitochondr Physiol Network 19.11.LEAK
ROUTINE
ETS
Intact cellsHumanBlood cells
Lymphocyte
El-Bacha 2014 Abstract MiP20142014Cytotoxicity of grape pomace extract (Vitis vinifera L.) from Brazilian wine industry in human hepatocarcinoma HepG2 cells.LEAK
ROUTINE
ETS
Intact cellsHumanLiver
Alberici 2014 Abstract MiP20142014Effects of long-chain acyl-CoA synthetase 6 knockdown in primary skeletal muscle cells metabolism.LEAK
ROUTINE
ETS
Intact cellsRatSkeletal muscle
Felser 2014 Abstract MiP20142014Assessing mitochondrial dysfunction in fibroblast cells – a comparison between O2k and multiwell respirometry.ROUTINE
ETS
ROXIntact cellsHumanEndothelial;epithelial;mesothelial cell
HeLa
Fibroblast
Nagy 2014 Abstract MiP20142014Investigation of the energy metabolism of microglial cells.ETS
ROUTINE
Intact cellsHumanNervous system
Widlund 2014 Abstract MiP20142014Resveratrol as a double edged sword on mitochondrial function.ROUTINEIntact cellsHeLa
Sonkar 2013 Abstract MiP20132013Sonkar VK, Dash D, Kulkarn PP (2013) Platelets, amyloid beta and mitochondrial respiration. Mitochondr Physiol Network 18.08.ROUTINEIntact cellsHumanBlood cells
Wieckowski 2013 Abstract MiP20132013Wieckowski MR, Karkucinska-Wieckowska A, Wojtala A, Lebiedzinska M, Pronicki M, Duszynski J (2013) Mitochondrial bioenergetic parameters, reactive oxygen species production and the status of antioxidant defense system can be used to differentiate mitochondrial defects studied in the fibroblasts from patients with various mitochondrial disorders. Mitochondr Physiol Network 18.08.ROUTINECIV
NS
Intact cellsHuman
Mouse
Fibroblast
Wojtala 2013 Abstract MiP20132013Wojtala A, Karkucinska-Wieckowska A, Lebiedzinska M, Duszynski J, Wieckowski MR(2013) Comparative studies of reactive oxygen species production and the level of antioxidant defense system in the fibroblasts derived from patients with defined mitochondrial disorders. Mitochondr Physiol Network 18.08.ROUTINEIntact cellsHumanFibroblast
Hickey 2013 Abstract MiP20132013Hickey AJ, Iftikar FI, MacDonald J, Baker D (2013) Mitochondria in a changing climate? The role of mitochondrial in hyperthermic heart failure in different fish species. Mitochondr Physiol Network 18.08.ETS
LEAK
OXPHOS
ROUTINE
CIV
N
NS
S
Permeabilized tissueFishes
Other mammals
Heart
Petit 2013 Abstract MiP20132013Petit PX (2013) The cardiolipin defect linked to a tafazzin mutation in Barth syndrome disturbs mitochondrial metabolism, alters apoptosis and autophagic fluxes but does not affect cell cycle progression. Mitochondr Physiol Network 18.08.ROUTINEIntact cellsHumanBlood cells
Other cell lines
HeLa
Menze 2013 Abstract MiP20132013Menze MA, Marunde MA, Samarajeewa DA, Anderson J, Li S, Hand SC (2013) Group1 LEA protein ameliorates inhibition of mitochondrial respiration in Drosophila melanogaster Kc167 cells and isolated mitochondria. Mitochondr Physiol Network 18.08.LEAK
ROUTINE
OXPHOS
NIntact organism
Intact cells
Permeabilized cells
Isolated mitochondria
Enzyme
Drosophila
Artemia
Crustaceans
Hexapods
Other cell lines
CHO
HEK
Macrophage-derived
Wright 2013 Abstract MiP20132013Wright L, Rizzuto R (2013) Calcium regulation of metabolism in adipocytes. Mitochondr Physiol Network 18.08.ROUTINEIntact cellsMouseFat
Other cell lines
Jezek 2013 Abstract MiP20132013Ježek P, Ježek J, Zelenka J, Dlasková A, Jabůrek M (2013) Antioxidant synergy of mitochondrial uncoupling protein UCP2 and phospholipase iPLA2γ. Mitochondr Physiol Network 18.08.LEAK
ROUTINE
OXPHOS
ETS
N
S
ROX
Intact cells
Isolated mitochondria
MouseLung;gill
Islet cell;pancreas;thymus
Garcia-Souza 2013 Abstract IOC802013Garcia-Souza LF (2013) Thrombin trigger mitochondrial functional remodeling in human platelets. Mitochondr Physiol Network 18.09.LEAK
ROUTINE
ETS
Intact cellsHumanBlood cells
Bouillaud 2013 Abstract MiP20132013Bouillaud F, Andriamihaja M, Mimoun S, Ransy C, Chaumontet C, Blachier F (2013) Adaptation of mitochondria in colonocytes to hydrogen sulfide exposure. Mitochondr Physiol Network 18.18.ROUTINEOther combinationsIntact cellsOther cell lines
Zelenka 2013 Abstract MiP20132013Zelenka J, Smolkova K, Dvorak A, Vitek L, Jezek P (2013) Reverse carboxylation glutaminolysis in breast cancer cells. Mitochondr Physiol Network 18.08.ROUTINEIntact cellsHumanOther cell lines
HeLa
Oliveira HC 2013 Abstract MiP20132013Oliveira HC, Dorighello GG, Rovani JC, Raposo HF, Paim BA, Vercesi AE (2013) Intermittent fasting improves oxidative stress but not metabolic disturbances and atherosclerosis in hypercholesterolemic mice. Mitochondr Physiol Network 18.08.ROUTINENIntact organism
Homogenate
Isolated mitochondria
MouseLiver
Hendricks 2013 Abstract MiP20132013Hendricks E, Nathan BP, Menze MA (2013) Bioenergetics of permeabilized and intact nerve cell terminals from ApoE deficient and wild type mice. Mitochondr Physiol Network 18.08.LEAK
ROUTINE
OXPHOS
ETS
N
S
NS
Intact cells
Permeabilized cells
Isolated mitochondria
MouseNervous system
Zelenka J 2013 Abstract MiP20132013Zelenka J, Alan L, Jezek P(2013) Response of cancer cells to mitochondrial DNA damage. Mitochondr Physiol Network 18.08.ROUTINE
ETS
Other cell lines
Oliveira MF 2013 Abstract MiP20132013Oliveira MF (2013) Comparative mitochondrial physiology in blood feeding insect vectors and parasites. Mitochondr Physiol Network 18.08.LEAK
ROUTINE
OXPHOS
ETS
F
N
S
Gp
CIV
ROX
Intact organism
Intact organ
Intact cells
Permeabilized cells
Permeabilized tissue
Homogenate
Human
Drosophila
Hexapods
Other invertebrates
Skeletal muscle
Neuroblastoma
Klamt 2013 Abstract IOC792013Klamt F (2013) Differences in basal mitochondrial respiratory parameters and reactive species generation between the cholinergic, dopaminergic and tumoral phenotypes of SH-SY5Y human neuroblastoma cell line. Mitochondr Physiol Network 18.07.ROUTINEIntact cellsHumanNeuroblastoma
Galina 2013 Abstract MiP20132013Galina A, Messeder DJM, Camacho-Pereira J, Pereira da Silva AP, Rodrigues-Ferreira C (2013) Effects of antitumor alkylating agent 3-bromopyruvate on energy transducing pathways in hepatoma HepG2, liver mitochondria and SERCA: Is there any role for mitochondrial hexokinase activity? Mitochondr Physiol Network 18.08.LEAK
ROUTINE
OXPHOS
ETS
N
S
Intact cells
Permeabilized cells
Isolated mitochondria
Enzyme
RatSkeletal muscle
Nervous system
Liver
Other cell lines
Camacho-Pereira 2013 Abstract IOC752013Camacho-Pereira J (2013) CD38 as a regulator of mitochondrial function. Mitochondr Physiol Network 18.03.ETS
LEAK
OXPHOS
ROUTINE
N
NS
S
Intact cells
Isolated mitochondria
Permeabilized cells
MouseHEK
Liver
Macrophage-derived
Rodrigues 2013 Abstract MiP20132013Rodrigues MF, Amoedo ND, Rumjanek FD (2013) Studies of bioenergetics alterations in breast cancer lines induced by histone desacetylase inhibitors. Mitochondr Physiol Network 18.08.LEAK
ROUTINE
ETS
ROXIntact cellsGenital
Amoedo 2013 Abstract MiP20132013Amoêdo ND, Rodrigues MF, Pereira S, Melo F, Jasiulionis M, Galina A, Rumjanek FD(2013) Comparative biochemistry of tumorigenesis: role of mitochondria in the metastatic process. Mitochondr Physiol Network 18.08.ETS
LEAK
OXPHOS
ROUTINE
N
ROX
S
Enzyme
Intact cells
Permeabilized cells
MouseEndothelial;epithelial;mesothelial cell
Other cell lines
Albertini 2012 Abstract Bioblast2012Albertini E, Koziel R, Duerr A, Neuhaus M, Jansen-Duerr P (2012) Cystathionine beta synthase modulates senescence of human endothelial cells. Mitochondr Physiol Network 17.12.LEAK
ROUTINE
ETS
Intact cellsEndothelial;epithelial;mesothelial cell
HUVEC
Mark 2012 Abstract Bioblast2012Mark FC, Strobel A, Poertner HO (2012) Ocean warming and acidification – when fish mitochondria turn sour. Mitochondr Physiol Network 17.12.LEAK
ROUTINE
OXPHOS
N
S
CIV
NS
Permeabilized tissue
Isolated mitochondria
FishesHeart
Liver
Acuna-Castroviejo 2012 Abstract Bioblast2012Acuna-Castroviejo D (2012) Melatonin and the quality of life: the melatonin-mitochondrion connection. Mitochondr Physiol Network 17.12.ROUTINE
OXPHOS
N
S
NS
Intact organism
Intact cells
Isolated mitochondria
Mouse
Rat
Heart
Skeletal muscle
Nervous system
Liver
Rodrigues 2012 Abstract IOC722012Rodrigues MF, Amoedo ND, Rumjanek FD (2012) Studies of bioenergetics alterations in breast cancer lines induced by sodium butyrate. Mitochondr Physiol Network 17.13.LEAK
ROUTINE
ETS
Watala 2012 Abstract Bioblast2012Watala C, Przygodzki T, Siewiera K, Kassassir H, Talar M, Labieniec-Watala M (2012) Oxygen consumption in resting and activated blood platelets: platelet mitochondria and cyclooxygenases as compounding targets for high-resolution respirometry. Mitochondr Physiol Network 17.12.ROUTINE
ETS
NS
ROX
Intact cells
Isolated mitochondria
Enzyme
Human
Rat
Endothelial;epithelial;mesothelial cell
Blood cells
Platelet
Stoeger 2012 Abstract Bioblast2012Stoeger H, Fontana-Ayoub M, Eigentler A, Gnaiger E (2012) Cell respiration with yeast as a model. Mitochondr Physiol Network 17.12.ROUTINEIntact cellsSaccharomyces cerevisiae
Fungi
Towheed 2012 Abstract IOC722012Towheed A (2012) Elucidating pathogenesis of ATP synthase dysfunction in a Drosophila model of mitochondrial encephalomyopathy. Mitochondr Physiol Network 17.13.LEAK
ROUTINE
OXPHOS
ETS
N
S
NS
Intact organism
Permeabilized tissue
Drosophila
Hexapods
Amoedo 2012 Abstract Bioblast2012Amoedo ND, Rodrigues MF, Pereira SAS, Melo FH, Jasiulionis MG, Galina A, Rumjanek FD (2012) Mitochondrial function and bioenergetics during malignant transformation and metastasis. Mitochondr Physiol Network 17.12.LEAK
ROUTINE
OXPHOS
ETS
SIntact cellsMouseOther cell lines
Silva MiP 20112011Silva da Costa L, Pereira da Silva AP, Da Poian AT, El-Bacha T (2011) Mitochondrial bioenergetic alterations in mouse neuroblastoma cells infected with Sindbis Virus: Implications to viral replication and neuronal death. MiP2011.ROUTINEIntact cellsNeuroblastoma
Itkis 2010 Abstract IOC602010Itkis YS (2010) Respirometry application in Leigh disease diagnostic and treatment. MiPNet15.10.ROUTINEIntact cellsHumanFibroblast