AT Innsbruck Gnaiger E

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AT Innsbruck Gnaiger E

OROBOROS O2k-Network

O2k-Network
O2k-Network Lab D. Swarovski Research Laboratory

Medical University of Innsbruck

Dept. Visceral, Transplant and Thoracic Surgery

>> See also AT Innsbruck OROBOROS

Address OROBOROS INSTRUMENTS

Schöpfstr. 18, A-6020

City Innsbruck
State/Prov
Country Austria
Weblink www.oroboros.at, www.bioblast.at, www.mitophysiology.org
Contact Gnaiger Erich
Team OROBOROS_Company#The_OROBOROS-Team
Team previous
Status 12 Power-O2k 1988-
OROBOROS Events International Oxygraph Courses since 1991
Topics Mitochondrial physiology, High-resolution respirometry


O2k-Publications

Published Reference
Schoepf 2016 FEBS J 2016 Schöpf B, Schöfer G, Weber A, Talasz H, Eder IE, Klocker H, Gnaiger E (2016) Oxidative phosphorylation and mitochondrial function differ between human prostate tissue and cultured cells. FEBS J 283:2181-96.
Krumschnabel 2015 Methods Mol Biol 2015
O2k-Protocols contents
Krumschnabel G, Fontana-Ayoub M, Sumbalova Z, Heidler J, Gauper K, Fasching M, Gnaiger E (2015) Simultaneous high-resolution measurement of mitochondrial respiration and hydrogen peroxide production. Methods Mol Biol 1264:245-61.
Burtscher 2015 Mitochondrion 2015 Burtscher J, Zangrandi L, Schwarzer C, Gnaiger E (2015) Differences in mitochondrial function in homogenated samples from healthy and epileptic specific brain tissues revealed by high-resolution respirometry. Mitochondrion 25:104-12.
Boushel 2015 Scand J Med Sci Sports 2015 Boushel R, Gnaiger E, Larsen FJ, Helge JW, Gonzalez-Alonso J, Ara I, Munch-Andersen T, van Hall G, Søndergaard H, Saltin B, Calbet JAL (2015) Maintained peak leg and pulmonary VO2 despite substantial reduction in muscle mitochondrial capacity. Scand J Med Sci Sports 25 (Suppl 4):135–43.
Harrison 2015 J Appl Physiol 2015 Harrison DK, Fasching M, Fontana-Ayoub M, Gnaiger E (2015) Cytochrome redox states and respiratory control in mouse and beef heart mitochondria at steady-state levels of hypoxia. J Appl Physiol 119:1210-8.
Gnaiger 2015 Scand J Med Sci Sports 2015 Gnaiger E, Boushel R, Søndergaard H, Munch-Andersen T, Damsgaard R, Hagen C, Díez-Sánchez C, Ara I, Wright-Paradis C, Schrauwen P, Hesselink M, Calbet JAL, Christiansen M, Helge JW, Saltin B (2015) Mitochondrial coupling and capacity of oxidative phosphorylation in skeletal muscle of Inuit and caucasians in the arctic winter. Scand J Med Sci Sports 25 (Suppl 4):126–34.
Makrecka-Kuka 2015 Biomolecules 2015
O2k-Protocols contents
Makrecka-Kuka M, Krumschnabel G, Gnaiger E (2015) High-resolution respirometry for simultaneous measurement of oxygen and hydrogen peroxide fluxes in permeabilized cells, tissue homogenate and isolated mitochondria. Biomolecules 5:1319-38.
Dueregger 2015 PLoS One 2015 Dueregger A, Schöpf B, Eder T, Höfer J, Gnaiger E, Aufinger A, Kenner L, Perktold B, Ramoner R, Klocker H, Eder IE (2015) Differential utilization of dietary fatty acids in benign and malignant cells of the prostate. PLoS One 10(8):e0135704.
Blatzer 2015 Antioxid Redox Signal 2015 Blatzer M, Jukic E, Posch W, Schöpf B, Binder U, Steger M, Blum G, Hackl H, Gnaiger E, Lass-Flörl C, Wilflingseder D (2015) Amphotericin B resistance in Aspergillus terreus is overpowered by co-application of pro-oxidants. Antioxid Redox Signal 23:1424-38.
Laner 2014 Mitochondr Physiol Network MiP2014 2014
MiPsociety
Laner V, Gnaiger E, eds (2014) Mitochondrial physiology – methods, concepts and biomedical perspectives. MiP2014. Mitochondr Physiol Network 19.13:88 pp. ISBN 978-3-9502399-9-7
Chicco 2014 J Exp Biol 2014 Chicco AJ, Le CH, Schlater AE, Nguyen AD, Kaye SD, Beals JW, Scalzo RL, Bell C, Gnaiger E, Costa DP, Crocker DE, Kanatous SB (2014) High fatty acid oxidation capacity and phosphorylation control despite elevated leak and reduced respiratory capacity in northern elephant seal muscle mitochondria. J Exp Biol 217:2947-55.
Krumschnabel 2014 Methods Enzymol 2014
O2k-Protocols contents
Krumschnabel G, Eigentler A, Fasching M, Gnaiger E (2014) Use of safranin for the assessment of mitochondrial membrane potential by high-resolution respirometry and fluorometry. Methods Enzymol 542:163-81.
Boushel 2014 Acta Physiol (Oxf) 2014 Boushel RC, Ara I, Gnaiger E, Helge JW, Gonzalez-Alonzo J, Munck-Andersen T, Sondergaard H, Damsgaard R, van Hall G, Saltin B, Calbet JA (2014) Low intensity training increases peak arm VO2 by enhancing both convective and diffusive O2 delivery. Acta Physiol (Oxf) 211:122-34.
Larsen 2014 Anal Biochem 2014 Larsen S, Kraunsøe R, Gram M, Gnaiger E, Helge JW, Dela F (2014) The best approach: homogenization or manual permeabilization of human skeletal muscle fibers for respirometry? Anal Biochem 446:64-8.
Gnaiger 2014 MitoPathways 2014
O2k-Protocols
Gnaiger E (2014) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 4th ed. Mitochondr Physiol Network 19.12. OROBOROS MiPNet Publications, Innsbruck:80 pp.
Khan 2014 J Comp Physiol 2014 Khan JR, Iftikar FI, Herbert NA, Gnaiger E, Hickey AJ (2014) Thermal plasticity of skeletal muscle mitochondrial activity and whole animal respiration in a common intertidal triplefin fish, Forsterygion lapillum (Family: Tripterygiidae). J Comp Physiol 184:991-1001.
Laner 2013 Mitochondr Physiol Network MiP2013 2013
MiPsociety
Laner V, Bidaurratzaga E, Gnaiger E, eds (2013) Comparative Mitochondrial Physiology. MiP2013. Mitochondr Physiol Network 18.08:96 pp. ISBN 978-3-9502399-7-3
Jacobs 2013 Exp Physiol 2013 Jacobs R, Boushel RC, Wright-Paradis C, Calbet JA, Robach P, Gnaiger E, Lundby C (2013) Mitochondrial function in human skeletal muscle following high altitude exposure. Exp Physiol 98:245-55.
Gnaiger 2012 Mitochondr Physiol Network Bioblast 2012 2012
OROBOROS
Gnaiger E, Meissner B, Laner V, eds (2012) Bioblast 2012: Mitochondrial Competence. Mitochondr Physiol Network 17.12. OROBOROS MiPNet Publications, Innsbruck:96 pp. ISBN 978-3-9502399-5-9
Larsen 2012 CryoLetters 2012 Larsen S, Wright-Paradis C, Gnaiger E, Helge JW, Boushel RC (2012) Cryopreservation of human skeletal muscle impairs mitochondrial function. Cryo Letters 33:170-6.
Pesta 2012 Methods Mol Biol 2012
O2k-Protocols
Pesta D, Gnaiger E (2012) High-resolution respirometry. OXPHOS protocols for human cells and permeabilized fibres from small biopsies of human muscle. Methods Mol Biol 810:25-58.
Robach 2012 Br J Sports Med 2012 Robach P, Siebenmann C, Jacobs R, Rasmussen P, Nordsborg N, Pesta D, Gnaiger E, Diaz V, Christ A, Fiedler J, Crivelli N, Secher NH, Pichon A, Maggiorini M, Lundby C (2012) The role of haemoglobin mass on VO2max following normobaric live high-train low in endurance-trained athletes. Br J Sports Med Jul 12. 46:822-7.
Iyer 2012 Hum Gene Ther 2012 Iyer S, Bergquist K, Young K, Gnaiger E, Rao RR, Bennett JP Jr (2012) Mitochondrial gene therapy improves respiration, biogenesis and transcription in G11778A Leber’s hereditary optic neuropathy and T8993G Leigh’s syndrome cells. Hum Gene Ther 23:647-57.
Votion 2012 PLoS One 2012 Votion DM, Gnaiger E, Lemieux H, Mouithys-Mickalad A, Serteyn D (2012) Physical fitness and mitochondrial respiratory capacity in horse skeletal muscle. PLoS One 7:e34890.
Jacobs 2011 J Appl Physiol 2011 Jacobs R, Rasmussen P, Siebenmann C, Díaz V, Pesta D, Gnaiger E, Nordsborg NB, Robach P, Lundby C (2011) Determinants of time trial performance and maximal incremental exercise in highly trained endurance athletes. J Appl Physiol 111:1422–30.
Pesta 2011 Am J Physiol Regul Integr Comp Physiol 2011 Pesta D, Hoppel F, Macek C, Messner H, Faulhaber M, Kobel C, Parson W, Burtscher M, Schocke M, Gnaiger E (2011) Similar qualitative and quantitative changes of mitochondrial respiration following strength and endurance training in normoxia and hypoxia in sedentary humans. Am J Physiol Regul Integr Comp Physiol 301:R1078–87.
Kristiansen 2011 J Biol Chem 2011 Kristiansen G, Hu J, Wichmann D, Stiehl DP, Rose M, Gerhardt J, Bohnert A, ten Haaf A, Moch H, Raleigh J, Varia MA, Subarsky P, Scandurra FM, Gnaiger E, Gleixner E, Bicker A, Gassmann M, Hankeln T, Dahl E, Gorr TA (2011) Endogenous myoglobin in breast cancer is hypoxia-inducible by alternate transcription and functions to impair mitochondrial activity: a role in tumor suppression? J Biol Chem 286:43417-28.
Boushel 2011 Mitochondrion 2011 Boushel RC, Gnaiger E, Calbet JA, Gonzalez-Alonso J, Wright-Paradis C, Sondergaard H, Ara I, Helge JW, Saltin B (2011) Muscle mitochondrial capacity exceeds maximal oxygen delivery in humans. Mitochondrion 11:303-7.
Eberhart 2011 Biochim Biophys Acta 2011 Eberhart K, Rainer J, Bindreither D, Ritter I, Gnaiger E, Kofler R, Oefner PJ, Renner K (2011) Glucocorticoid-induced alterations in mitochondrial membrane properties and respiration in childhood acute lymphoblastic leukemia. Biochim Biophys Acta 1807:719-25.
Lemieux 2011 Int J Biochem Cell Biol 2011 Lemieux H, Semsroth S, Antretter H, Höfer D, Gnaiger E (2011) Mitochondrial respiratory control and early defects of oxidative phosphorylation in the failing human heart. Int J Biochem Cell Biol 43:1729–38.
Renner-Sattler 2010 Mitochondr Physiol Network MiP2010 2010
MiPsociety
Renner-Sattler K, Gnaiger E, eds (2010) Mitochondrial physiology. The many functions of the organism in our cells. Mitochondr Physiol Network 15.6:128 pp. ISBN 978-3-9502399-4-2
Aguirre 2010 Biochim Biophys Acta 2010 Aguirre E, Rodríguez-Juárez F, Bellelli A, Gnaiger E, Cadenas S (2010) Kinetic model of the inhibition of respiration by endogenous nitric oxide in intact cells. Biochim Biophys Acta 1797:557-65.
Sommer 2010 Eur Respir J 2010 Sommer N, Pak O, Schörner S, Derfuss T, Krug A, Gnaiger E, Ghofrani HA, Schermuly RT, Huckstorf C, Seeger W, Grimminger F, Weissmann N (2010) Mitochondrial cytochrome redox states and respiration in acute pulmonary oxygen sensing. Eur Respir J 36:1056-66.
Kozlov 2010 Inflammation 2010 Kozlov AV, van Griensven M, Haindl S, Kehrer I, Duvigneau JC, Hartl RT, Ebel T, Jafarmadar M, Calzia E, Gnaiger E, Redl H, Radermacher P, Bahrami Sl (2010) Peritoneal inflammation in pigs is associated with early mitochondrial dysfunction in liver and kidney. Inflammation 33:295-305.
Sjoevall 2010 Crit Care 2010 Sjoevall F, Morota S, Hansson Magnus J, Friberg H, Gnaiger E, Elmer E (2010) Temporal increase of platelet mitochondrial respiration is negatively associated with clinical outcome in patients with sepsis. Crit Care 14:R214.
Scandurra 2010 Adv Exp Med Biol 2010 Scandurra FM, Gnaiger E (2010) Cell respiration under hypoxia: facts and artefacts in mitochondrial oxygen kinetics. Adv Exp Med Biol 662:7-25.
Smolkova 2010 J Bioenerg Biomembr 2010 Smolková K, Bellance N, Scandurra F, Génot E, Gnaiger E, Plecitá-Hlavatá L, Ježek P, Rossignol R (2010) Mitochondrial bioenergetic adaptations of breast cancer cells to aglycemia and hypoxia. J Bioenerg Biomembr 42:55-67.
Gnaiger 2009 Int J Biochem Cell Biol 2009 Gnaiger E (2009) Capacity of oxidative phosphorylation in human skeletal muscle. New perspectives of mitochondrial physiology. Int J Biochem Cell Biol 41:1837-45.
Gnaiger 2008 POS 2008
O2k-Protocols contents
Gnaiger E (2008) Polarographic oxygen sensors, the oxygraph and high-resolution respirometry to assess mitochondrial function. In: Mitochondrial Dysfunction in Drug-Induced Toxicity (Dykens JA, Will Y, eds) John Wiley & Sons, Inc, Hoboken, NJ:327-52.
Aragones 2008 Nat Genet 2008 Aragonés J, Schneider M, Van Geyte K, Fraisl P, Dresselaers T, Mazzone M, Dirkx R, Zacchigna S, Lemieux H, Jeoung NH, Lambrechts D, Bishop T, Lafuste P, Diez-Juan A, K Harten S, Van Noten P, De Bock K, Willam C, Tjwa M, Grosfeld A, Navet R, Moons L, Vandendriessche T, Deroose C, Wijeyekoon B, Nuyts J, Jordan B, Silasi-Mansat R, Lupu F, Dewerchin M, Pugh C, Salmon P, Mortelmans L, Gallez B, Gorus F, Buyse J, Sluse F, Harris RA, Gnaiger E, Hespel P, Van Hecke P, Schuit F, Van Veldhoven P, Ratcliffe P, Baes M, Maxwell P, Carmeliet P (2008) Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism. Nat Genet 40:170-80.
Rostrup M 2008 Amino Acids 2008 Rostrup M, Fossbakk A, Hauge A, Kleppe R, Gnaiger E, Haavik J (2008) Oxygen dependence of tyrosine hydroxylase. Amino Acids 34:455-64.
Schneeberger 2008 Shock 2008 Schneeberger S, Kuznetsov AV, Seiler R, Renz O, Meusburger H, Mark W, Brandacher G, Margreiter R, Gnaiger E (2008) Mitochondrial ischemia-reperfusion injury of the transplanted rat heart: improved protection by preservation versus cardioplegic solutions. Shock 30:365-71.
Boushel 2007 Diabetologia 2007 Boushel RC, Gnaiger E, Schjerling P, Skovbro M, Kraunsoee R, Dela F (2007) Patients with Type 2 diabetes have normal mitochondrial function in skeletal muscle. Diabetologia 50:790-6.
Stadlmann 2006 Cell Biochem Biophys 2006 Stadlmann S, Renner K, Pollheimer J, Moser PL, Zeimet AG, Offner FA, Gnaiger E (2006) Preserved coupling of oxydative phosphorylation but decreased mitochondrial respiratory capacity in IL-1ß treated human peritoneal mesothelial cells. Cell Biochem Biophys 44:179-86.
Cadenas 2006 Biochim Biophys Acta 2006 Aguirre E, Rodriguez-Juarez F, Gnaiger E, Cadenas S (2006) Measurement of the control of cellular respiration by nitric oxide under normoxia and hypoxia: instrumental comparison including high-resolution respirometry. Biochim Biophys Acta, EBEC Short Reports Suppl 14:136-7.
Huetter 2006 Exp Gerontol 2006 Hütter E, Unterluggauer H, Garedew A, Jansen-Dürr P, Gnaiger E (2006) High-resolution respirometry - a modern tool in aging research. Exp Gerontol 41:103-9.
Garedew 2005 Eur Shock Soc 2005 Garedew A, Hütter E, Haffner B, Gradl P, Gradl L, Jansen-Dürr P, Gnaiger E (2005) High-resolution respirometry for the study of mitochondrial function in health and disease. The OROBOROS O2k. Proc 11th Congress Eur Shock Soc, Vienna, Austria (Redl H, ed) Medimond, Bologna:107-11.
Huetter 2004 Biochem J 2004 Hütter E, Renner K, Pfister G, Stöckl P, Jansen-Dürr P, Gnaiger E (2004) Senescence-associated changes in respiration and oxidative phosphorylation in primary human fibroblasts. Biochem J 380:919-28.
Kuznetsov 2004 Am J Physiol Heart Circ Physiol 2004 Kuznetsov AV, Schneeberger S, Seiler R, Brandacher G, Mark W, Steurer W, Saks V, Usson Y, Margreiter R, Gnaiger E (2004) Mitochondrial defects and heterogeneous cytochrome c release after cardiac cold ischemia and reperfusion. Am J Physiol Heart Circ Physiol 286:H1633–41.
Pecina 2004 Am J Physiol Cell Physiol 2004 Pecina P, Gnaiger E, Zeman J, Pronicka E, Houstek J (2004) Decreased affinity to oxygen of cytochrome c oxidase in Leigh syndrome caused by SURF1 mutations. Am J Physiol Cell Physiol 287:C1384-8.
Gnaiger 2003 Adv Exp Med Biol 2003 Gnaiger E (2003) Oxygen conformance of cellular respiration. A perspective of mitochondrial physiology. Adv Exp Med Biol 543:39-55.
Renner 2003 Biochim Biophys Acta 2003 Renner K, Amberger A, Konwalinka G, Gnaiger E (2003) Changes of mitochondrial respiration, mitochondrial content and cell size after induction of apoptosis in leukemia cells. Biochim Biophys Acta 1642:115-23.
Huetter 2002 Mol Biol Rep 2002 Hütter E, Renner K, Jansen-Dürr P, Gnaiger E (2002) Biphasic oxygen kinetics of cellular respiration and linear oxygen dependence of antimycin A inhibited oxygen consumption. Mol Biol Rep 29:83-7.
Kuznetsov 2002 Anal Biochem 2002 Kuznetsov AV, Strobl D, Ruttmann E, Königsrainer A, Margreiter R, Gnaiger E (2002) Evaluation of mitochondrial respiratory function in small biopsies of liver. Anal Biochem 305:186-94.
Steininger 2002 J Antimicrob Chemother 2002 Steininger C, Allerberger F, Gnaiger E (2002) Clinical significance of inhibition kinetics in Streptococcus pyogenes in response to penicillin. J Antimicrob Chemother 50:517-23.
Renner 2002 Mol Biol Rep 2002 Renner K, Kofler R, Gnaiger E (2002) Mitochondrial function in glucocorticoid triggered T-ALL cells with transgenic Bcl-2 expression. Mol Biol Rep 29:97-101.
Stadlmann 2002 Transplantation 2002 Stadlmann S, Rieger G, Amberger A, Kuznetsov AV, Margreiter R, Gnaiger E (2002) H2O2-mediated oxidative stress versus cold ischemia-reperfusion: mitochondrial respiratory defects in cultured human endothelial cells. Transplantation 74:1800-3.
Gnaiger 2002 Biochem Soc Trans 2002 Gnaiger E, Kuznetsov AV (2002) Mitochondrial respiration at low levels of oxygen and cytochrome c. Biochem Soc Trans 30:242-8.
Gnaiger 2001 Respir Physiol 2001 Gnaiger E (2001) Bioenergetics at low oxygen: dependence of respiration and phosphorylation on oxygen and adenosine diphosphate supply. Respir Physiol 128:277-97.
Kuznetsov 2000 Transplant Proc 2000 Kuznetsov AV, Brandacher G, Steurer W, Margreiter R, Gnaiger E (2000) Isolated rat heart mitochondria and whole heart as models for mitochondrial cold ischemia-reperfusion injury. Transplant Proc 32:45.
Gnaiger 2000 Transplant Proc 2000 Gnaiger E, Kuznetsov AV, Königsrainer A, Margreiter R (2000) Autooxidation of glutathione in organ preservation solutions. Transplant Proc 32:14.
Gnaiger 2000 Life in the Cold 2000
O2k-Protocols contents
Gnaiger E, Kuznetsov AV, Schneeberger S, Seiler R, Brandacher G, Steurer W, Margreiter R (2000) Mitochondria in the cold. In: Life in the Cold (Heldmaier G, Klingenspor M, eds) Springer, Heidelberg, Berlin, New York:431-42.
Gnaiger 2000 Transpl Int 2000 Gnaiger E, Kuznetsov AV, Rieger G, Amberger A, Fuchs A, Stadlmann S, Eberl T, Margreiter R (2000) Mitochondrial defects by intracellular calcium overload versus endothelial cold ischemia/reperfusion injury. Transpl Int 13:555-7.
Gnaiger 2000 Proc Natl Acad Sci U S A 2000 Gnaiger E, Méndez G, Hand SC (2000) High phosphorylation efficiency and depression of uncoupled respiration in mitochondria under hypoxia. Proc Natl Acad Sci U S A 97:11080-5.
Kuznetsov 1999 Transplant Proc 1999 Kuznetsov AV, Brandacher G, Steurer W, Margreiter R, Gnaiger E (1999) Estimation of mitochondrial damage in heart preservation. Transplant Proc 31:992.
Oexle 1999 Biochim Biophys Acta 1999 Oexle H, Gnaiger E, Weiss G (1999) Iron-dependent changes in cellular energy metabolism: influence on citric acid cycle and oxidative phosphorylation. Biochim Biophys Acta 1413:99-107.
Stadlmann 1999 Transplant Proc 1999 Stadlmann S, Amberger A, Kuznetsov AV, Rieger G, Hengster P, Margreiter R, Gnaiger E (1999) Does H2O2-mediated oxidative stress reproduce mitochondrial cold preservation/reoxygenation injury in endothelial cells? Transplant Proc 31:993.
Steurer 1999 Transplant Proc 1999 Steurer W, Stadlmann S, Roberts K, Fischer M, Margreiter R, Gnaiger E (1999) Quality assessment of isolated pancreatic rat islets by high-resolution respirometry. Transplant Proc 31:650.
Gnaiger 1999 Transplant Proc 1999 Gnaiger E, Rieger G, Stadlmann S, Amberger A, Eberl T, Margreiter R (1999) Mitochondrial defect in endothelial cold ischemia/reperfusion injury. Transplant Proc 31:994-5.
Gnaiger 1998 J Exp Biol 1998 Gnaiger E, Lassnig B, Kuznetsov AV, Rieger G, Margreiter R (1998) Mitochondrial oxygen affinity, respiratory flux control, and excess capacity of cytochrome c oxidase. J Exp Biol 201:1129-39.
Kuznetsov 1998 BTK 1998 Kuznetsov AV, Lassnig B, Margreiter R, Gnaiger E (1998) Diffusion limitation of oxygen versus ADP in permeabilized muscle fibers. In BioThermoKinetics in the Post Genomic Era (Larsson C, Påhlman I-L, Gustafsson L, eds) Chalmers Reproservice, Göteborg:273-6.
Lassnig 1998 BTK 1998 Lassnig B, Kuznetsov AV, Margreiter R, Gnaiger E (1998) Aerobic-anoxic transitions and regulation of mitochondrial oxygen flux. In BioThermoKinetics in the Post Genomic Era (Larsson C, Påhlman I-L, Gustafsson L, eds) Chalmers Reproservice, Göteborg:312-6.
Gnaiger 1998 BTK-COX 1998 Gnaiger E, Kuznetsov AV, Lassnig B, Margreiter R (1998) Functional interpretation of the flux control coefficient and excess capacity of cytochrome c oxidase at intracellular oxygen. In BioThermo-Kinetics in the Post Genomic Era (Larsson C, Påhlman I-L, Gustafsson L, eds) Chalmers Reproservice, Göteborg:81-8.
Gnaiger 1998 BTK-HRR 1998 Gnaiger E, Kuznetsov AV, Lassnig B, Fuchs A, Reck M, Renner K, Stadlmann S, Rieger G, Margreiter R (1998) High-resolution respirometry. Optimum permeabilization of the cell membrane by digitonin. In BioThermoKinetics in the Post Genomic Era (Larsson C, Pahlman I-L, Gustafsson L, eds) Chalmers Reproservice, Göteborg:89-95.
Gnaiger 1998 Biochim Biophys Acta 1998 Gnaiger E, Lassnig B, Kuznetsov AV, Margreiter R (1998) Mitochondrial respiration in the low oxygen environment of the cell: Effect of ADP on oxygen kinetics. Biochim Biophys Acta 1365:249-54.
Sperl 1997 Mol Cell Biochem 1997 Sperl W, Skladal D, Gnaiger E, Wyss M, Mayr U, Hager J, Gellerich FN (1997) High resolution respirometry of premeabilized skeletal muscle fibers in the diagnosis of neuromuscular disorders. Mol Cell Biochem 174:71-8.
Gnaiger 1997 Transplant Proc 1997 Gnaiger E, Rieger G, Kuznetsov A, Fuchs A, Stadlmann S, Lassnig B, Hengster P, Eberl T, Margreiter R (1997) Mitochondrial ischemia-reoxygenation injury and plasma membrane integrity in human endothelial cells. Transplant Proc 29:3524-6.
Steinlechner-Maran 1997 Transplantation 1997 Steinlechner-Maran R, Eberl T, Kunc M, Schröcksnadel H, Margreiter R, Gnaiger E (1997) Respiratory defect as an early event in preservation/reoxygenation injury in endothelial cells. Transplantation 63:136-42.
Gnaiger 1996 BTK-441 1996 Gnaiger E, Reck M, Steinlechner-Maran R, Rieger G, Stadlmann S, Margreiter R (1996) High resolution - the decisive difference in mitochondrial and cellular respirometry. In BioThermoKinetics of the Living Cell (Westerhoff HV, Snoep JL, Wijker JE, Sluse FE, Kholodenko BN, eds), BioThermo-Kinetics, Amsterdam:441-2.
Steinlechner-Maran 1996 Am J Physiol Cell Physiol 1996 Steinlechner-Maran R, Eberl T, Kunc M, Margreiter R, Gnaiger E (1996) Oxygen dependence of respiration in coupled and uncoupled endothelial cells. Am J Physiol Cell Physiol 271:C2053-61.
Gnaiger 1995 J Bioenerg Biomembr 1995 Gnaiger E, Steinlechner-Maran R, Méndez G, Eberl T, Margreiter R (1995) Control of mitochondrial and cellular respiration by oxygen. J Bioenerg Biomembr 27:583-96.
Gellerich 1995 HRR 1995 Gellerich FN, Skladal D, Schranzhofer R, Lanznaster N, Kunz WS, Wisniewski E, Kuznetsov A, Krishmer M, Gnaiger E, Margreiter R, Sperl W (1995) Hochauflösende Respirometrie und multiple Substrat/Inhibitor-Titration zum funktionellen Nachweis mitochondrialer Defekte in permeabilisierten Muskelfasern. In: Molekulare Grundlage hereditärer Myopathien. (Gross M, Gresser U, Hrsg), Zuckschwerdt Verlag, München, Bern, Wien, New York:52-66.
Kemp 1994 BTK-226 1994
BTK1994
Kemp RB, Hoare S, Schmalfeldt M, Bridge ChMC, Evansa PM, Gnaiger E (1994) A thermochemical study of the producion of lactate by glutaminolysis and glycolysis in mouse macrophage hybridoma cells. In: What is Controlling Life? (Gnaiger E, Gellerich FN, Wyss M, eds) Modern Trends in BioThermoKinetics 3. Innsbruck Univ Press:226-31.
Gellerich 1994 BTK-263 1994
BTK1994
Gellerich FN, Steinlechner R, Wyss M, Eberl T, Müller LC, Skladal D, Sperl W, Dapunt O, Margreiter R, Gnaiger E (1994) Mitochondrial function in the atrial appendage of the human heart. Characterization by high-resolution respirometry. In: What is Controlling Life? (Gnaiger E, Gellerich FN, Wyss M, eds) Modern Trends in BioThermo-Kinetics 3. Innsbruck Univ Press:263-7.
Gnaiger 1994 BTK 1994
BTK1994
Gnaiger E, Gellerich FN, Wyss M (1994) What is controlling life? 50 years after Erwin Schrödinger's What is life? Modern trends in BiothermoKinetics 3, Innsbruck Univ Press:336 pp.
Laterveer 1994 BTK-186 1994
BTK1994
Laterveer FD, Gellerich FN, Gnaiger E, Nicolay K (1994) Macromolecules increase the channeling of ADP from mitochondrially associated hexokinase to the mitochondrial matrix. In: What is Controlling Life? (Gnaiger E, Gellerich FN, Wyss M, eds) Modern Trends in BioThermoKinetics 3. Innsbruck Univ Press:186-90.
Haller 1994 Anal Biochem 1994 Haller T, Ortner M, Gnaiger E (1994) A respirometer for investigating oxidative cell metabolism. Toward optimization of respiratory studies. Anal Biochem 218:338-42.
Eberl 1994 BTK-288 1994
BTK1994
Eberl T, Steinlechner R, Salvenmoser W, Abendstein B, Rhomberg M, Schröcksnadel H, Schmid T, Gnaiger E, Margreiter R (1994) Endothelial cell cultures as a model for organ preservation studies. In: What is Controlling Life? (Gnaiger E, Gellerich FN, Wyss M, eds) Modern Trends in BioThermoKinetics 3. Innsbruck Univ Press:288-93.
Knoblechner 1994 BTK-294 1994
BTK1994
Knoblechner A, Steinlechner R, Schirmer M, Gellerich FN, Margreiter R, Konwalinka G, Gnaiger E (1994) The effect of 2-chlorodeoxy-adenosine on endogenous respiration of a human lymphoma cell line (U-937). In: What is Controlling Life? (Gnaiger E, Gellerich FN, Wyss M, eds) Modern Trends in BioThermoKinetics 3. Innsbruck Univ Press:294-6.
Mendez 1994 BTK-191 1994
BTK1994
Méndez G, Gnaiger E (1994) How does oxygen pressure control oxygen flux in isolated mitochondria? A methodological approach by high-resolution respirometry and digital data analysis. In: What is Controlling Life? (Gnaiger E, Gellerich FN, Wyss M, eds) Modern Trends in BioThermo-Kinetics 3. Innsbruck Univ Press:191-4.
Skladal 1994 BTK-268 1994
BTK1994
Skladal D, Sperl W, Schranzhofer R, Krismer M, Gnaiger E, Margreiter R, Gellerich FN (1994) Preservation of mitochondrial functions in human skeletal muscle during storage in high energy preservation solution (HEPS). In: What is Controlling Life? (Gnaiger E, Gellerich FN, Wyss M, eds) Modern Trends in BioThermoKinetics 3. Innsbruck Univ Press:268-71.
Sperl 1994 J Inher Metab Dis 1994 Sperl W, Skladal D, Lanznaster N, Schranzhofer R, Zaunschirm G, Gnaiger E, Gellerich FN (1994) Polarographic studies of saponin-skinned muscle fibers in patients with mitochondrial myopathies. J Inher Metab Dis 17:307-10.
SteinlechnerMaran 1994 BTK-283 1994
BTK1994
Steinlechner-Maran R, Eberl T, Margreiter R, Gnaiger E (1994) Oxygen dependence of cellular respiration in endothelial cells: A sensitive toxicological test. In: What is Controlling Life? (Gnaiger E, Gellerich FN, Wyss M, eds) Modern Trends in BioThermo-Kinetics 3. Innsbruck Univ Press:283-7.
Gellerich 1994 BTK-181 1994
BTK1994
Gellerich FN, Laterveer FD, Gnaiger E, Nicolay K (1994) Effect of macromolecules on ADP-transport into mitochondria. In: What is Controlling Life? (Gnaiger E, Gellerich FN, Wyss M, eds) Modern Trends in BioThermoKinetics 3. Innsbruck Univ Press:181-5.
Buck 1993 Am J Physiol Regul Integr Comp Physiol 1993 Buck LT, Hochachka PW, Schön A, Gnaiger E (1993) Microcalorimetric measurement of reversible metabolic suppression induced by anoxia in isolated hepatocytes. Am J Physiol Regul Integr Comp Physiol 265:R1014-9.
Gnaiger 1992 Funct Ecol 1992 Gnaiger E (1992) Optimum efficiency of energy transformation and the evolution of catabolic pathways. Funct Ecol 6:234-41.
Haller 1990 CYCYCLOBIOS Mitos 1990 Haller T (1990) Methodological considerations for respiratory studies with isolated mitochondria. CYCLOBIOS Newsletter 4:51-5.
Haller 1990 CYCLOBIOS Kinetics 1990 Haller T, Gnaiger E (1990) Kinetic control and reaction pressure in steady state coupled mitochondria. CYCLOBIOS Newsletter 4:63-6.
Raich 1990 CYCLOBIOS 1990 Raich K, Haller T, Gnaiger E (1990) The kinetics of mitochondria isolated from oligochaetes: Comparison with classical rat liver mitochondria. CYCLOBIOS Newsletter 4:77-9.
Gnaiger 1990 CYCLOBIOS 1990 Gnaiger E, Steinlechner R, Doeller JE, Haller T, eds (1990) Calorimetry, Respirometry and Mitochondrial Energetics. CYCLOBIOS Newsletter 4:93 pp.
Schoen 1990 Cyclobios 1990 Schön A, Haller T, Gnaiger E (1990) Hexokinase induced, steady state coupled mitochondria studied by injection calorimetry and respirometry. CYCLOBIOS Newsletter 4:67-72.
Gnaiger 1983 Springer POS 1983 Gnaiger E, Forstner H, eds (1983) Polarographic Oxygen Sensors. Aquatic and Physiological Applications. Springer, Berlin, Heidelberg, New York:370 pp.


O2k-Abstracts

Published Reference
Gnaiger 2016 UMDF2016 2016 Schöpf B, Schäfer G, Weber A, Talasz H, Eder IE, Klocker H, Gnaiger E (2016) Oxidative phosphorylation and mitochondrial function differ between human prostate tissue and cultured cells.
Chicco 2016b Abstract MitoFit Science Camp 2016 2016 OXPHOS coupling efficiency of permeabilized muscle fibers predicts metabolic efficiency of subjects exercising at 5260 m.
Doerrier 2015 Abstract MiP2015 2015 Simultaneous measurement of mitochondrial respiration, hydrogen peroxide production, and NADH autofluorescence to assess mitochondrial function.
Hoppel 2015 Abstract MiPschool London 2015 2015 Human blood cell types as study models of mitochondrial respiration and H2O2 production.
Volani 2015 Abstract IOC106 2015 Volani C, Haschka D, Demetz E, Doerrier C, Gnaiger E, Weiss G (2015) Determination of mitochondrial respiration in peripheral blood mononuclear cells. Mitochondr Physiol Network 20.10.
Laner 2015 Abstract MiPschool Greenville 2015 2015 Comparative mitochondrial physiology: OXPHOS and ETS capacity in permeabilized fibres of canine superathletes.
Doerrier 2015 Abstract MiPschool Greenville 2015 2015 "Succinate paradox" study by high resolution respirometry combined with fluorometry and spectrofluorometry: NextGen-O2k.
Hoppel 2015 Abstract MiP2015 2015 Effects of ultramarathon performance on mitochondrial respiration in human platelets.
Laner 2015 Abstract MiP2015 2015 Comparative mitochondrial physiology: OXPHOS and ETS capacity in permeabilized fibres of canine superathletes.
Sumbalova 2015 Abstract MiP2015 2015 High-resolution measurement of mitochondrial membrane potential and respiration – comparison of potentiometric and fluorometric methods.
Laner 2015 Abstract MiPschool Cape Town 2015 2015 The OROBOROS Oxygraph-2k for high-resolution respirometry and O2k-Fluorometry: a new quality in OXPHOS analysis.
Gnaiger 2015 Abstract MiPschool Cape Town 2015 2015 The functional design of the electron transfer system: substrate control of mitochondrial respiration.
Gnaiger 2015 Abstract MiP2015 2015 Mitochondrial function of cyropreserved HEK 293T cells: development of a reference sample for high-resolution respirometry.
Harrison 2014 Abstract MiP2014 2014 The relationship between cytochrome redox state and oxygen consumption in isolated mouse and beef heart mitochondria during hypoxia.
Schoepf 2014 Abstract MiP2014 2014 OXPHOS analysis in small prostate biopsies.
Sumbalova 2014 Abstract MiP2014 2014 Optimization of malate concentration for high-resolution respirometry: mitochondria from rat liver and brain.
Laner 2014 Abstract MiP2014 2014 Cytochrome c flux control factor as a quality criterion in respiratory OXPHOS analysis in canine permeabilized fibres.
Burtscher 2014 Abstract MiP2014 2014 Region-specific differences in Complex I- and Complex II-linked respiration in the mouse brain.
Krumschnabel 2014 Abstract MiP2014 2014 Simultaneous high-resolution measurement of mitochondrial respiration and hydrogen peroxide production.
Laner 2013 ASMRM 2013 Laner V, Gradl P, Eigentler A, Fontana-Ayoub M, Fasching M, Gnaiger E (2013) The OROBOROS Oxygraph-2k for high-resolution respirometry and O2k-Fluorometry: a new quality in OXPHOS analysis. ASMRM2013.
Gnaiger 2013 Abstract ASMRM 2013 Gnaiger E(2013) Loss of mitochondrial competence and degenerative disease: cause and effect. Abstract ASMRM-Seoul.
Krumschnabel 2013 Abstract MiP2013 2013 Krumschnabel G, Eigentler A, Fontana-Ayoub M, Draxl A, Fasching M, Gnaiger E (2013) Tissue homogenates for respiratory OXPHOS analysis in comparative mitochondrial physiology: mouse and trout – heart and liver. Mitochondr Physiol Network 18.08.
Gnaiger 2013 Abstract Neurocon Kolkata 2013 Gnaiger E (2013) Body mass index and the risk of neurodegeneration: from mitochondrial fitness to brain function. Abstract Neurocon 2013, Kolkata, India. Symposium: Neurocon 2013. January 17-20.
Gnaiger 2013 Abstract MiP2013 2013 Gnaiger E, Søndergaard H, Munch-Andersen T, Damsgaard R, Hagen C, Díez-Sánchez C, Ara I, Wright-Paradis C, Schrauwen P, Hesselink M, Calbet J, Christiansen M, Helge JW, Saltin B, Boushel R (2013) Biochemical coupling efficiency in permeabilized fibres from arm and leg muscle in Inuit versus Caucasians: A functional test of the uncoupling hypothesis in Greenland. Mitochondr Physiol Network 18.08.
Sumbalova 2012 Abstract Bioblast 2012 Sumbalova Z, Fasching M, Erich Gnaiger E (2012) Evaluation of mitochondrial respiration and membrane potential in mouse brain homogenate. Mitochondr Physiol Network 17.12:61.
Harrison 2012 Abstract Bioblast 2012 Harrison DK, Fasching M (2012) O2k-Spectrophotometry – A MitoCom Project. Mitochondr Physiol Network 17.12.
Eigentler 2012 Abstract Bioblast 2012 Eigentler A, Draxl A, Fontana-Ayoub M, Gnaiger E (2012) The PBI-Shredder - an auxiliary HRR-tool for the preparation of tissue homogenates for diagnosis of mitochondrial respiratory function. Mitochondr Physiol Network 17.12.
OROBOROS 2012 Abstract Bioblast 2012 OROBOROS (2012) 20 Years High-Resolution Respirometry – OROBOROS INSTRUMENTS and WGT. Mitochondr Physiol Network 17.12.
Stoeger 2012 Abstract Bioblast 2012 Stoeger H, Fontana-Ayoub M, Eigentler A, Gnaiger E (2012) Cell respiration with yeast as a model. Mitochondr Physiol Network 17.12.
Gnaiger 2012 Abstract Bioblast-Gentle Science 2012 Gnaiger E (2012) Gentle Science and the Bioblast Conference. Mitochondr Physiol Network 17.12.
Gnaiger 2012 Abstract-FEPS-Santiago de Compostela 2012 Gnaiger E (2012) Aging and mitochondrial physiology. The effect of exercise and caloric balance on oxidative phosphorylation (OXPHOS). Abstract FEPS, Santiago de Compostela, Spain. Symposium: Advances in Aging and Mitochondria Research. September 08-12.
Fasching 2012 Abstract Bioblast 2012 Fasching M, Sumbalova Z, Gnaiger E (2012) O2k-Fluorometry - a MitoCom project. Mitochondr Physiol Network 17.12.
Gnaiger 2011 Abstract-Berlin 2011 Gnaiger E (2011) Fewer mitochondria - mitochondrial 'fever': Mitochondrial physiology and capacity of oxidative phosphorylation in active and sedentary life styles. Abstract Targeting Mitochondria Berlin.
Pesta 2011Abstract Mitochondrial Medicine-Training 2011 Pesta D, Hoppel F, Macek C, Messner H, Faulhaber M, Kobel C, Parson W, Burtscher M, Schocke M, Gnaiger E (2011) Mitochondrial improvements after strength, endurance, and intermittend hypoxic training in sedentary humans. A respiratory study on permeabilized muscle fibres. Abstract Mitochondrial Medicine Chicago.
Fasching 2011 Abstract Berlin 2011 Fasching M, Harrison DK, Tretter L, Gnaiger E (2011) Combination of high-resolution respirometry and fluorometry for continuous monitoring of hydrogen peroxide production by mitochondria with resolution in the nanomolar range. Abstract Berlin.
Sumbalova 2011 Abstract Bordeaux 2011 Sumbalova Z, Wiethuechter A, Fasching M, Gnaiger E (2011) Coupling control and substrate control of mitochondrial membrane potential and respiration in the mouse brain, and comparison with skeletal and cardiac muscle. Abstract MiP2011, Bordeaux.
Pesta 2011Abstract Mitochondrial Medicine-Diagnosis 2011 Pesta D, Wiethuechter A, Karall D, Schocke M, Gnaiger E (2011) Functional mitochondrial diagnosis in a patient suffering from sudden exercise intolerance. Abstract Mitochondrial Medicine Chicago.
Sumbalova 2011 Abstract Kagoshima 2011 Sumbalova Z, Harrison DK, Gradl P, Fasching M, Gnaiger E (2011) Mitochondrial membrane potential, coupling control, H2O2 production, and the upper limit of mitochondrial performance. Abstract Kagoshima.
Gnaiger 2011 Abstract SMRM-Hyderabad 2011 Gnaiger E, Wright-Paradis C, Sondergaard H, Calbet J, Damsgaard R, Munck-Andersen T, Saltin B, Boushel RC (2011) Conserved mitochondrial coupling and adaptive substrate control in Inuit and Caucasians: Acclimatization to active life styles in the Arctic winter. Abstract SMRM-Hyderabad.
Lemieux 2011 Abstract Bordeaux 2011 Lemieux H, Semsroth S, Antretter H, Hoefer D, Gnaiger E (2011) Increased OXPHOS capacity after cold preservation of the human heart – a paradox resolved by a dyscoupling mechanism. MiP2011
Gnaiger 2011 Abstract-MonteVerita 2011 Gnaiger E (2011) Mitochondrial respiratory capacity at maximum aerobic exercise levels: Are intracellular oxygen levels limiting? Abstract Monte Verita.
Sumbalova 2011Abstract Mitochondrial Medicine 2011 Sumbalova Z, Fasching M, Gnaiger E (2011) Substrate control in mitochondrial respiration and regulation of mitochondrial membrane potential. Abstract Mitochondrial Medicine Chicago.
Pesta 2010 MiP Abstract 2010 Pesta D, Faulhaber M, Burtscher M, Gnaiger E, Schocke M (2010) Investigation of muscle metabolism of the M. quadriceps via 31P MRS and high-resolution respirometry in connection with 10 weeks of strength and endurance training in normoxia and hypoxia. MiP2010.
Pesta 2010 Abstract IOC60 2010 Pesta D, Macek C, Hoppel F, Faulhaber M, Burtscher M, Gnaiger E, Schocke M (2010) The impact of endurance training on muscle oxidative capacity. MiPNet15.10.
Gnaiger Abstract MiP2010 2-01 2010 Gnaiger E (2010) Measuring the upper limit of mitochondrial performance - how and why?
Garedew 2006 Biochim Biophys Acta 2006 Garedew A, Lemieux H, Schachner T, Blier PU, Tardif J-C, Gnaiger E (2006) High excess capacity of cytochrome c oxidase in permeabilized fibers of the mouse heart. Biochim Biophys Acta, EBEC Short Reports Suppl 14 (2006):167-8.
Lemieux 2006 Biochim Biophys Acta 2006 Lemieux H, Garedew A, Blier PU, Tardif J-C, Gnaiger E (2006) Temperature effects on the control and capacity of mitochondrial respiration in permeabilized fibers of the mouse heart. Biochim Biophys Acta, EBEC Short Reports Suppl 14 (2006):201-2.


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