Metformin: Difference between revisions
From Bioblast
No edit summary |
No edit summary |
||
Line 9: | Line 9: | ||
== References: Metformin == | == References: Metformin == | ||
:::# | {{#ask:[[Category:Publications]] [[Additional label::Metformin]] | ||
|?Was published in year=Year | |||
|?Has title=Reference | |||
|?Mammal and model=Organism | |||
|?Tissue and cell=Tissue;cell | |||
|format=broadtable | |||
|limit=5000 | |||
|offset=0 | |||
|sort=Was published in year | |||
|order=descending | |||
}} | |||
{{#ask:[[Category:Abstracts]] [[Additional label::Metformin]] | |||
|?Was submitted in year=Year | |||
|?Has title=Reference | |||
|?Mammal and model=Organism | |||
|?Tissue and cell=Tissue;cell | |||
|format=broadtable | |||
|limit=5000 | |||
|offset=0 | |||
|sort=Was submitted in year | |||
|order=descending | |||
}} | |||
:::# Dantas-Ferreira RF, Raingard H, Dumont S, Schuster-Klein C, Guardiola-Lemaitre B, Pevet P, Challet E (2018) Melatonin potentiates the effects of metformin on glucose metabolism and food intake in high-fat-fed rats. Endocrinol Diabetes Metab 1:e00039. - https://www.ncbi.nlm.nih.gov/pubmed/30815567 | :::# Dantas-Ferreira RF, Raingard H, Dumont S, Schuster-Klein C, Guardiola-Lemaitre B, Pevet P, Challet E (2018) Melatonin potentiates the effects of metformin on glucose metabolism and food intake in high-fat-fed rats. Endocrinol Diabetes Metab 1:e00039. - https://www.ncbi.nlm.nih.gov/pubmed/30815567 | ||
:::# Alshahrani A, AlDubayee M, Zahra M, Alsebayel FM, Alammari N, Alsudairy F, Almajed M, Aljada A (2019) Differential expression of human N-alpha-acetyltransferase 40 (hNAA40), nicotinamide phosphoribosyltransferase (NAMPT) and Sirtuin-1 (SIRT-1) pathway in obesity and T2DM: modulation by metformin and macronutrient intake. Diabetes Metab Syndr Obes 12:2765-74. - https://www.ncbi.nlm.nih.gov/pubmed/31920356 | :::# Alshahrani A, AlDubayee M, Zahra M, Alsebayel FM, Alammari N, Alsudairy F, Almajed M, Aljada A (2019) Differential expression of human N-alpha-acetyltransferase 40 (hNAA40), nicotinamide phosphoribosyltransferase (NAMPT) and Sirtuin-1 (SIRT-1) pathway in obesity and T2DM: modulation by metformin and macronutrient intake. Diabetes Metab Syndr Obes 12:2765-74. - https://www.ncbi.nlm.nih.gov/pubmed/31920356 |
Revision as of 03:26, 12 February 2020
Description
Metformin is mainly known as an important antidiabetic drug which is effective, however, in a wide spectrum of degenerative diseases. It is an inhibitor of Complex I.
Reference: Brunmair 2004 Diabetes
Metformin and mitObesity
Work in progress by Gnaiger E 2020-02-10 linked to a preprint in preparation on BME and mitObesity.
References: Metformin
Year | Reference | Organism | Tissue;cell | |
---|---|---|---|---|
LaMoia 2022 Proc Natl Acad Sci U S A | 2022 | LaMoia TE, Butrico GM, Kalpage HA, Goedeke L, Hubbard BT, Vatner DF, Gaspar RC, Zhang XM, Cline GW, Nakahara K, Woo S, Shimada A, Hüttemann M, Shulman GI (2022) Metformin, phenformin, and galegine inhibit complex IV activity and reduce glycerol-derived gluconeogenesis. Proc Natl Acad Sci U S A 119:e2122287119. https://doi.org/10.1073/pnas.2122287119 | ||
Siewiera 2022 Int J Mol Sci | 2022 | Siewiera K, Labieniec-Watala M, Kassassir H, Wolska N, Polak D, Watala C (2022) Potential role of mitochondria as modulators of blood platelet activation and reactivity in diabetes and effect of metformin on blood platelet bioenergetics and platelet activation. https://doi.org/10.3390/ijms23073666 | Rat | Platelet |
Zhao 2021 Trends Cancer | 2021 | Zhao H, Swanson KD, Zheng B (2021) Therapeutic repurposing of biguanides in cancer. Trends Cancer 7:714-30. https://doi.org/10.1016/j.trecan.2021.03.001 | ||
Kenny 2019 Circ Res | 2019 | Kenny HC, Abel ED (2019) Heart failure in Type 2 Diabetes Mellitus. Circ Res 124:121–41. | Human | Heart |
Gabandé-Rodríguez 2019 Cells | 2019 | Gabandé-Rodríguez E, M Gómez de Las Heras M, Mittelbrunn M (2019) Control of inflammation by calorie restriction mimetics: on the crossroad of autophagy and mitochondria. Cells 2019;9:E82. | ||
Teh 2019 Mol Cancer Ther | 2019 | Teh JT, Zhu WL, Newgard CB, Casey PJ, Wang M (2019) Respiratory capacity and reserve predict cell sensitivity to mitochondria inhibitors: mechanism-based markers to identify metformin-responsive cancers. Mol Cancer Ther 18:693-705. | Human Mouse | Other cell lines |
Ruegsegger 2019 JCI Insight | 2019 | Ruegsegger GN, Vanderboom PM, Dasari S, Klaus KA, Kabiraj P, McCarthy CB, Lucchinetti CF, Nair KS (2019) Exercise and metformin counteract altered mitochondrial function in the insulin-resistant brain. JCI Insight 4:130681. | Mouse | Nervous system |
Machado 2019 MitoFit Preprint Arch EA | 2019 | Machado Ivo F, Teodoro JS, Palmeira CM, Rolo AP (2019) Interplay between metformin and miR-378a-3p in cells under hyperglycaemia. https://doi.org/10.26124/mitofit:ea19.MiPSchool.0008 | ||
Wilmanns 2018 Mol Metab | 2018 | Wilmanns JC, Pandey R, Hon O, Chandran A, Schilling JM, Forte E, Wu Q, Cagnone G, Bais P, Philip V, Coleman D, Kocalis H, Archer SK, Pearson JT, Ramialison M, Heineke J, Patel HH, Rosenthal NA, Furtado MB, Costa MW (2018) Metformin intervention prevents cardiac dysfunction in a murine model of adult congenital heart disease. Mol Metab 20:102-14. | Mouse | Heart |
Machado-Neto 2018 Cell Death Dis | 2018 | Machado-Neto JA, Fenerich BA, Scopim-Ribeiro R, Eide CA, Coelho-Silva JL, Dechandt CRP, Fernandes JC, Rodrigues Alves APN, Scheucher PS, Simões BP, Alberici LC, de Figueiredo Pontes LL, Tognon CE, Druker BJ, Rego EM, Traina F (2018) Metformin exerts multitarget antileukemia activity in JAK2V617F-positive myeloproliferative neoplasms. Cell Death Dis 9:311. | Human Mouse | Other cell lines |
Rivas 2018 Am J Physiol Endocrinol Metab | 2018 | Rivas E, Herndon DN, Porter C, Meyer W, Suman OE. (2018) Short-term metformin and exercise training effects on strength, aerobic capacity, glycemic control, and mitochondrial function in children with burn injury.. Am J Physiol Endocrinol Metab. 314(3):E232-E240. | Human | Skeletal muscle |
Piel 2018 Intensive Care Med Exp | 2018 | Piel S, Ehinger JK, Chamkha I, Frostner EÅ, Sjövall F, Elmér E, Hansson MJ (2018) Bioenergetic bypass using cell-permeable succinate, but not methylene blue, attenuates metformin-induced lactate production. Intensive Care Med Exp 6:22. | Human | Platelet Blood cells |
Tai 2018 Acta Pharm Sin B | 2018 | Tai Y, Li L, Peng X, Zhu J, Mao X, Qin N, Ma M, Huo R, Bai Y, Dong D (2018) Mitochondrial uncoupler BAM15 inhibits artery constriction and potently activates AMPK in vascular smooth muscle cells. Acta Pharm Sin B 8:909-18. | Mouse | Endothelial;epithelial;mesothelial cell |
Christensen 2018 Diabetes Metab Res Rev | 2018 | Christensen M, Schiffer TA, Gustafsson H, Krag SP, Nørregaard R, Palm F (2018) Metformin attenuates renal medullary hypoxia in diabetic nephropathy through uncoupling protein-2 inhibition. Diabetes Metab Res Rev 21:e3091. | Rat | Kidney |
Arnoux 2018 Elife | 2018 | Arnoux I, Willam M, Griesche N, Krummeich J, Watari H, Offermann N, Weber S, Narayan Dey P, Chen C, Monteiro O, Buettner S, Meyer K, Bano D, Radyushkin K, Langston R, Lambert JJ, Wanker E, Methner A, Krauss S, Schweiger S, Stroh A (2018) Metformin reverses early cortical network dysfunction and behavior changes in Huntington's disease. Elife 7:e38744. | Mouse | Nervous system |
Konopka 2018 Aging Cell | 2018 | Konopka AR, Laurin JL, Schoenberg HM, Reid JJ, Castor WM, Wolff CA, Musci RV, Safairad OD, Linden MA, Biela LM, Bailey SM, Hamilton KL, Miller BF (2018) Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults. Aging Cell 18:e12880. | Human | Skeletal muscle |
Zhou 2018 Cell Death Dis | 2018 | Zhou C, Sun H, Zheng C, Gao J, Fu Q, Hu N, Shao X, Zhou Y, Xiong J, Nie K, Zhou H, Shen L, Fang H, Lyu J (2018) Oncogenic HSP60 regulates mitochondrial oxidative phosphorylation to support Erk1/2 activation during pancreatic cancer cell growth. Cell Death Dis 9:161. | Human | Islet cell;pancreas;thymus Other cell lines |
Schommers 2017 Mol Metab | 2017 | Schommers P, Thurau A, Bultmann-Mellin I, Guschlbauer M, Klatt AR, Rozman J, Klingenspor M, de Angelis MH, Alber J, Gründemann D, Sterner-Kock A, Wiesner RJ (2017) Metformin causes a futile intestinal-hepatic cycle which increases energy expenditure and slows down development of a type 2 diabetes-like state. Mol Metab 6:737-47. | Mouse | |
Wetzel 2017 Thesis | 2017 | Wetzel MD (2017) Mechanism of metformin action in dermal fibroblasts. PhD Thesis 125. | Human | Fibroblast |
Pecinova 2017 Oxid Med Cell Longev | 2017 | Pecinova A, Drahota Z, Kovalcikova J, Kovarova N, Pecina P, Alan L, Zima M, Houstek J, Mracek T (2017) Pleiotropic effects of biguanides on mitochondrial reactive oxygen species production. Oxid Med Cell Longev 7038603. | Rat | Fat |
Timmers 2016 Diabetes Care | 2016 | Timmers S, de Ligt M, Phielix E, van de Weijer T, Hansen J, Moonen-Kornips E, Schaart G, Kunz I, Hesselink MK, Schrauwen-Hinderling VB, Schrauwen P (2016) Resveratrol as add-on therapy in subjects with well-controlled type 2 diabetes: a randomized controlled trial. Diabetes Care 39:2211-17. | Human | Skeletal muscle |
Villani 2016 Mol Metab | 2016 | Villani LA, Smith BK, Marcinko K, Ford RJ, Broadfield LA, Green AE, Houde VP, Muti P, Tsakiridis T, Steinberg GR (2016) The diabetes medication Canagliflozin reduces cancer cell proliferation by inhibiting mitochondrial complex-I supported respiration. Mol Metab 5:1048-56. | Human | Genital |
Cahova 2016 Am J Physiol Gastrointest Liver Physiol | 2016 | Cahova M, Palenickova E, Dankova H, Sticova E, Burian M, Drahota Z, Cervinkova Z, Kucera O, Gladkova C, Stopka P, Krizova J, Papackova Z, Oliyarnyk O, Kazdova L (2016) Metformin prevents ischemia reperfusion-induced oxidative stress in the fatty liver by attenuation of reactive oxygen species formation. Am J Physiol Gastrointest Liver Physiol 309:G100-11. | Rat | Liver |
Alcocer-Gomez 2016 Biochim Biophys Acta | 2016 | Alcocer-Gómez E, Garrido-Maraver J, Bullón P, Marín-Aguilar F, Cotán D, Carrión AM, Alvarez-Suarez JM, Giampieri F, Sánchez-Alcazar JA, Battino M, Cordero MD (2016) Metformin and caloric restriction induce an AMPK-dependent restoration of mitochondrial dysfunction in fibroblasts from Fibromyalgia patient. Biochim Biophys Acta 1852:1257-67. | Mouse | Fibroblast |
Rajh 2016 PLOS ONE | 2016 | Rajh M, Dolinar K, Miš K, Pavlin M, Pirkmajer (2016) Medium renewal blocks antiproliferative effects of metformin in cultured MDA-MB-231 breast cancer cells. PLOS ONE 11:e0154747. | Human | Genital Other cell lines |
Cheng 2016 Nat Immunol | 2016 | Cheng SC, Scicluna BP, Arts RJ, Gresnigt MS, Lachmandas E, Giamarellos-Bourboulis EJ, Kox M, Manjeri GR, Wagenaars JA, Cremer OL, Leentjens J, van der Meer AJ, van de Veerdonk FL, Bonten MJ, Schultz MJ, Willems PH, Pickkers P, Joosten LA, van der Poll T, Netea MG (2016) Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis. Nat Immunol 17:406-13. | Human | Blood cells Lymphocyte |
Drahota 2014 Physiol Res | 2014 | Drahota Z, Palenickova E, Endlicher R, Milerova M, Brejchova J, Vosahlikova M, Svoboda P, Kazdova L, Kalous M, Cervinkova Z, Cahova M (2014) Biguanides inhibit Complex I, II and IV of rat liver mitochondria and modify their functional properties. Physiol Res 63:1-11. | Rat | Liver |
Cheng 2014 Science | 2014 | Cheng SC, Quintin J, Cramer RA, Shepardson KM, Saeed S, Kumar V, Giamarellos-Bourboulis EJ, Martens JH, Rao NA, Aghajanirefah A, Manjeri GR6, Li Y, Ifrim DC, Arts RJ, van der Meer BM, Deen PM, Logie C, O'Neill LA, Willems P, van de Veerdonk FL, van der Meer JW, Ng A, Joosten LA, Wijmenga C, Stunnenberg HG, Xavier RJ, Netea MG (2014) mTOR- and HIF-1 α–mediated aerobic glycolysis as metabolic basis for trained immunity. Science 345:1250684. | Human | Blood cells Other cell lines |
Wessels 2014 PLoS One | 2014 | Wessels B, Ciapaite J, van den Broek NMA, Nicolay K, Prompers JJ (2014) Metformin impairs mitochondrial function in skeletal muscle of both lean and diabetic rats in a dose-dependent manner. PLoS One 9:e100525. | Rat | Skeletal muscle |
Svendsen 2014 Thesis | 2014 | Svendsen PF (2014) Metabolic aspects of polycystic ovary syndrome and obesity. Thesis Copenhagen University Hospital:38 pp. | Human | |
Piel 2014 Acta Physiol (Oxf) | 2014 | Piel S, Ehinger JK, Elmér E, Hansson Magnus J (2014) Metformin induces lactate production in peripheral blood mononuclear cells and platelets through specific mitochondrial Complex I inhibition. Acta Physiol (Oxf) 213:171-80. | Human | Blood cells Other cell lines Platelet |
Kristensen 2013 PLoS One | 2013 | Kristensen JM, Larsen S, Helge JW, Dela F, Wojtaszewski JFP (2013) Two weeks of metformin treatment enhances mitochondrial respiration in skeletal muscle of AMPK kinase dead but not wild type mice. PLoS One 8:e53533. | Mouse | Skeletal muscle |
Benes 2011 Clin Sci (Lond) | 2011 | Benes J, Kazdova L, Drahota Z, Houstek J, Medrikova D, Kopecky J, Kovarova N, Vrbacky M, Sedmera D, Strnad H, Kolar M, Petrak J, Benada O, Skaroupkova P, Cervenka L, Melenovsky V (2011) Effect of metformin therapy on cardiac function and survival in a volume-overload model of heart failure in rats. Clin Sci (Lond) 121:29-41. | Rat | Heart |
Palenickova 2011 Physiol Res | 2011 | Palenickova E, Cahova M, Drahota Z, Kazdova L, Kalous M (2011) Inhibitory effect of metformin on oxidation of NADH-dependent substrates in rat liver homogenate. Physiol Res 60:835-9. | Rat | Liver |
Kane 2010 Free Radic Biol Med | 2010 | Kane DA, Anderson EJ, Price III JW, Woodlief TL, Lin C-T, Bikman BT, Cortright RN, Neufer PD (2010) Metformin selectively attenuates mitochondrial H2O2 emission without affecting respiratory capacity in skeletal muscle of obese rats. Free Radic Biol Med 49:1082–7. | Rat | Skeletal muscle |
Canto 2009 Nature | 2009 | Cantó AC, Gerhart-Hines Z, Feige JN, Lagouge M, Noriega L, Milne JC, Elliott PJ, Puigserver P, Auwerx J (2009) AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature 458:1056-60. | Mouse | Skeletal muscle |
Morota 2009 Exp Neurol | 2009 | Morota S, Månsson R, Hansson Magnus J, Kasuya K, Shimazu M, Hasegawa E, Yanagi S, Omi A, Uchino H, Elmér E (2009) Evaluation of putative inhibitors of mitochondrial permeability transition for brain disorders-specificity vs. toxicity. Exp Neurol 218:353-62. | Human | Liver |
Brunmair 2004 Diabetes | 2004 | Brunmair B, Staniek K, Gras F, Scharf N, Althaym A, Clara R, Roden M, Gnaiger E, Nohl H, Waldhäusl W, Fürnsinn C (2004) Thiazolidinediones, like metformin, inhibit respiratory Complex I: a common mechanism contributing to their antidiabetic actions? Diabetes 53:1052-9. | Rat | Skeletal muscle Liver |
El-Mir 2000 J Biol Chem | 2000 | El-Mir MY, Nogueira V, Fontaine E, Avéret N, Rigoulet M, Leverve X (2000) Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain Complex I. J Biol Chem 275:223-8. https://doi.org/10.1074/jbc.275.1.223 | Rat |
Year | Reference | Organism | Tissue;cell | |
---|---|---|---|---|
Jeremic 2019 MiP2019 | 2019 | Neurotoxic effect of extracellular alpha-synuclein can be alleviated by AMPK and autophagy. | Human | Neuroblastoma |
Avram 2019 MiP2019 | 2019 | Cell-permeable succinate bypasses statin-induced decrease in mitochondrial ATP-generating respiration in human platelets. | Human | Platelet |
Pavlovic 2019 MiP2019 | 2019 | Effects of therapeutic metformin concentration on mitochondria in muscle cells. | Mouse | Skeletal muscle |
Konopka 2018 FASEB J | 2018 | Konopka AR, Castor WM, Reid J, Schoenberg H, Laurin J, Wolff C, Hamilton K, Miller B (2018) Metformin blunts exercise-induced improvements in skeletal muscle mitochondrial respiration independent of changes in mitochondrial biogenesis. FASEB J. | Human | Skeletal muscle |
Siewiera 2018 MiPschool Tromso E2 | 2018 | Effect of metformin treatment on blood platelet bioenergetics and platelet function in STZ-diabetic and non-diabetic rats. | Rat | Platelet |
Avram 2018 MiP2018 | 2018 | Cell-permeable succinate bypasses statin-induced mitochondrial complex I inhibition in human platelets. Avram_Presentation | Human | Platelet |
Labieniec-Watala 2017 MiP2017 | 2017 | Lack of the effect of low metformin concentrations on the response of breast cancer cell mitochondria to radiotherapy under conditions of the in vitro experimental hyperglycemia. Labieniec-Watala_Presentation | Human | Genital |
Pecinova 2017 MiP2017 | 2017 | Targeting tumor cell proliferation by inhibition of mitochondrial metabolic pathways. | ||
Brazdova 2017 MiP2017 | 2017 | Pleiotropic effects of biguanides on mitochondrial reactive oxygen species production. | Fat | |
Scatena 2017 MITOEAGLE Obergurgl | 2017 | Cancer stem cell differentiation induced by PPAR ligands. Which role for an inhibition of mitochondrial respiratory chain? | Human | Liver |
Forbes-Hernandez 2017 MiPschool Obergurgl | 2017 | The reduction of mitochondrial functionality by a strawberry extract: a mechanism that contributes to its lipid-lowering effect? | Human | Liver |
Siewiera 2017 Abstract MITOEAGLE Barcelona | 2017 | The effect of metformin on blood platelet bioenergetics and platelet function. | Human | Blood cells Platelet |
Kopitar-Jerala 2017 Abstract MITOEAGLE Barcelona | 2017 | |||
Scatena 2017 Abstract MITOEAGLE Barcelona | 2017 | Mitochondria and cancer stem cells in hepatocarcinoma. An illustrative example of a tangled methodological approach. | Liver | |
Murphy 2016 Abstract FASEB J | 2016 | Metformin limits loss of mitochondrial respiration seen with doxorubicin treatment without affecting muscle function. | Mouse | Skeletal muscle |
Ehinger 2015 Abstract MiPschool London 2015 | 2015 | Cell-permeable mitochondrial complex II substrates – a new compound class for treatment of complex I-linked mitochondrial disease. | Human | Heart Blood cells Fibroblast |
Jana Prado 2014 Abstract MiP2014 | 2014 | Defining the role of mitochondrial electron transfer Complex I on the modulation of Ca2+ homeostasis: effects of metformin on cancer cell metabolism. Mitochondr Physiol Network 19.13. |
- Dantas-Ferreira RF, Raingard H, Dumont S, Schuster-Klein C, Guardiola-Lemaitre B, Pevet P, Challet E (2018) Melatonin potentiates the effects of metformin on glucose metabolism and food intake in high-fat-fed rats. Endocrinol Diabetes Metab 1:e00039. - https://www.ncbi.nlm.nih.gov/pubmed/30815567
- Alshahrani A, AlDubayee M, Zahra M, Alsebayel FM, Alammari N, Alsudairy F, Almajed M, Aljada A (2019) Differential expression of human N-alpha-acetyltransferase 40 (hNAA40), nicotinamide phosphoribosyltransferase (NAMPT) and Sirtuin-1 (SIRT-1) pathway in obesity and T2DM: modulation by metformin and macronutrient intake. Diabetes Metab Syndr Obes 12:2765-74. - https://www.ncbi.nlm.nih.gov/pubmed/31920356
- Sanches-Silva A, Testai L, Nabavi SF, Battino M, Devi KP, Tejada S, Sureda A, Xu S, Yousefi B, Majidinia M, Russo GL, Efferth T, Nabavi SM, Farzaei MH (2020) Therapeutic potential of polyphenols in cardiovascular diseases: regulation of mTOR signaling pathway. Pharmacol Res 2020 Jan 2:104626. - https://www.ncbi.nlm.nih.gov/pubmed/31904507
- Srivastava SB (2019) Is there a prescription to treat pediatric obesity? Am J Lifestyle Med 14:36-9. - https://www.ncbi.nlm.nih.gov/pubmed/31903078
- McCrimmon RJ, Catarig AM, Frias JP, Lausvig NL, le Roux CW, Thielke D, Lingvay I (2020) Effects of once-weekly semaglutide vs once-daily canagliflozin on body composition in type 2 diabetes: a substudy of the SUSTAIN 8 randomised controlled clinical trial. Diabetologia 2020 Jan 2. doi: 10.1007/s00125-019-05065-8. - https://www.ncbi.nlm.nih.gov/pubmed/31897524
- Kothari S, Dhami-Shah H, Shah SR (2019) Antidiabetic drugs and statins in nonalcoholic fatty liver disease. J Clin Exp Hepatol 9:723-30. - https://www.ncbi.nlm.nih.gov/pubmed/31889754
- Hiluy JC, Nazar BP, Gonçalves WS, Coutinho W, Appolinario JC (2019) Effectiveness of pharmacologic interventions in the management of weight gain in patients with severe mental illness: a systematic review and meta-analysis. Prim Care Companion CNS Disord 21 pii: 19r02483. - https://www.ncbi.nlm.nih.gov/pubmed/31856432
- Crocker CL, Baumgarner BL, Kinsey ST (2019) β-guanidinopropionic acid and metformin differentially impact autophagy, mitochondria and cellular morphology in developing C2C12 muscle cells. J Muscle Res Cell Motil. 2019 Dec 13. doi: 10.1007/s10974-019-09568-0. - https://www.ncbi.nlm.nih.gov/pubmed/31836952
- Guo H, Kong W, Zhang L, Han J, Clark LH, Yin Y, Fang Z, Sun W, Wang J, Gilliam TP, Lee D, Makowski L, Zhou C, Bae-Jump VL (2019) Reversal of obesity-driven aggressiveness of endometrial cancer by metformin. Am J Cancer Res 9:2170-93. - https://www.ncbi.nlm.nih.gov/pubmed/31720081
- Wang Y, An H, Liu T, Qin C, Sesaki H, Guo S, Radovick S, Hussain M, Maheshwari A, Wondisford FE, O'Rourke B, He L (2019) Metformin improves mitochondrial respiratory activity through activation of AMPK. Cell Rep 29:1511-23.e5. - https://www.ncbi.nlm.nih.gov/pubmed/31693892
- MacNeil LT, Schertzer JD, Steinberg GR (2020) Bacteria transmit metformin-associated lifespan extension. Nat Rev Endocrinol 16:9-10. - https://www.ncbi.nlm.nih.gov/pubmed/31645681
- El-Sayed SM, Ibrahim HM (2019) Effect of high-fat diet-induced obesity on thyroid gland structure in female rats and the possible ameliorating effect of metformin therapy. Folia Morphol (Warsz). 2019 Sep 6. doi: 10.5603/FM.a2019.0100. - https://www.ncbi.nlm.nih.gov/pubmed/31489607
- Hartman SJ, Nelson SH, Marinac CR, Natarajan L, Parker BA, Patterson RE (2019) The effects of weight loss and metformin on cognition among breast cancer survivors: Evidence from the Reach for Health study. Psychooncology 28:1640-46. - https://www.ncbi.nlm.nih.gov/pubmed/31140202
- Rotermund C, Machetanz G, Fitzgerald JC (2018) The therapeutic potential of metformin in neurodegenerative diseases. Front Endocrinol (Lausanne) 9:400. - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060268/
- Glossmann HH, Lutz OMD (2019) Metformin and aging: a review. Gerontology 65:581-90. - https://www.karger.com/Article/FullText/502257#
- Saraei P, Asadi I, Kakar MA, Moradi-Kor N (2019) The beneficial effects of metformin on cancer prevention and therapy: a comprehensive review of recent advances. Cancer Manag Res 11:3295-313. - https://www.ncbi.nlm.nih.gov/pubmed/31114366
- Higgins L, Palee S, Chattipakorn SC, Chattipakorn N (2019) Effects of metformin on the heart with ischaemia-reperfusion injury: Evidence of its benefits from in vitro, in vivo and clinical reports. Eur J Pharmacol 858:172489. - https://www.sciencedirect.com/science/article/pii/S0014299919304418
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5654524/
- https://www.ncbi.nlm.nih.gov/pubmed/30151735
- https://journals.lww.com/jhypertension/Abstract/2017/01000/Effects_of_metformin_on_blood_pressure_in.4.aspx
- https://pubmed.ncbi.nlm.nih.gov/28208582-nutrients-in-energy-and-one-carbon-metabolism-learning-from-metformin-users/?from_term=Obesity+and+comorbidities+and+mitochondria&from_page=4&from_pos=1
MitoPedia: mitObesity drugs
Healthy reference population | Body mass excess | BFE | BME cutoffs | BMI | H | M | VO2max | mitObesity drugs |
MitoPedia concepts:
MiP concept
Labels:
MitoPedia:mitObesity drug