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Curcumin

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Curcumin

Description

Curcumin has been shown to possess significant anti-inflammatory, anti-oxidant, anti-carcinogenic, anti-mutagenic, anti-coagulant and anti-infective effects. The protective effects of curcumin on rat heart mitochondrial injuries induced by in vitro anoxia–reoxygenation were evaluated by Xu et al 2013. It was found that curcumin added before anoxia or immediately prior to reoxygenation exhibited remarkable protective effects against anoxia–reoxygenation induced oxidative damage to mitochondria.


Reference: Xu et al 2013

Communicated by Doerrier C (2015-03-03).

Curcumin and mitObesity

Work in progress by Gnaiger E 2020-02-09 linked to a preprint in preparation on mitObesity drugs.

References: Curcumin

 YearReferenceOrganismTissue;cellPathology
Ceja-Galicia 2022 Antioxidants (Basel)2022Ceja-Galicia ZA, García-Arroyo FE, Aparicio-Trejo OE, El-Hafidi M, Gonzaga-Sánchez G, León-Contreras JC, Hernández-Pando R, Guevara-Cruz M, Tovar AR, Rojas-Morales P, Aranda-Rivera AK, Sánchez-Lozada LG, Tapia E, Pedraza-Chaverri J (2022) Therapeutic effect of curcumin on 5/6Nx hypertriglyceridemia: association with the improvement of renal mitochondrial β-oxidation and lipid metabolism in kidney and liver. https://doi.org/10.3390/antiox11112195RatKidneyOther
Kener 2018 J Vis Exp2018Kener KB, Munk DJ, Hancock CR, Tessem JS (2018) High-resolution respirometry to measure mitochondrial function of intact beta cells in the presence of natural compounds. J Vis Exp 131.Islet cell;pancreas;thymusDiabetes
Tueller 2017 Biochem Biophys Res Commun2017Tueller DJ, Harley JS, Hancock CR (2017) Effects of curcumin and ursolic acid on the mitochondrial coupling efficiency and hydrogen peroxide emission of intact skeletal myoblasts. Biochem Biophys Res Commun 492:368-72.Skeletal muscle
Ortega-Dominguez 2017 Food Chem Toxicol2017Ortega-Domínguez B, Aparicio-Trejo OE, García-Arroyo FE, León-Contreras JC, Tapia E, Molina-Jijón E, Hernández-Pando R, Sánchez-Lozada LG, Barrera-Oviedo D, Pedraza-Chaverri J (2017) Curcumin prevents cisplatin-induced renal alterations in mitochondrial bioenergetics and dynamic. Food Chem Toxicol 107:373-85.
Hagl 2015 Neurochem Int2015Hagl S, Kocher A, Schiborr C, Kolesova N, Frank J, Eckert GP (2015) Curcumin micelles improve mitochondrial function in neuronal PC12 cells and brains of NMRI mice - Impact on bioavailability. Neurochem Int 89:234-42.MouseNervous system
Hagl 2014 J Alzheimers Dis b2014Hagl S, Heinrich M, Kocher A, Schiborr C, Frank J, Eckert GP (2014) Curcumin micelles improve mitochondrial function in a mouse model of Alzheimer’s disease. J Alzheimers Dis 1:80-3.MouseNervous systemAlzheimer's
Hirzel 2013 J Recept Signal Transduct Res2013Hirzel E, Lindinger PW, Maseneni S, Giese M, Rhein VV, Eckert A, Hoch M, Krähenbühl S, Eberle AN (2013) Differential modulation of ROS signals and other mitochondrial parameters by the antioxidants MitoQ, resveratrol and curcumin in human adipocytes. J Recept Signal Transduct Res 33:304-12.HumanFat
Other cell lines
Eckert 2013 Neurochem Int2013Eckert GP, Schiborr C, Hagl S, Abdel-Kader R, Müller WE, Rimbach G, Frank J (2013) Curcumin prevents mitochondrial dysfunction in the brain of the senescence-accelerated mouse-prone 8. Neurochem Int 62:595-602.MouseAging;senescence
Eckert 2012 Mol Neurobiol2012Eckert GP, Renner K, Eckert SH, Eckmann J, Hagl S, Abdel-Kader RM, Kurz C, Leuner K, Muller WE (2012) Mitochondrial dysfunction - a pharmacological target in Alzheimer's disease. Mol Neurobiol 46:136-50.Human


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  8. Yang YSH, Li ZL, Shih YJ, Bennett JA, Whang-Peng J, Lin HY, Davis PJ, Wang K (2019) Herbal medicines attenuate PD-L1 expression to induce anti-proliferation in obesity-related cancers. Nutrients 11 pii: E2979. - https://www.ncbi.nlm.nih.gov/pubmed/31817534
  9. Rocha-Ferreira E, Sisa C, Bright S, Fautz T, Harris M, Contreras Riquelme I, Agwu C, Kurulday T, Mistry B, Hill D, Lange S, Hristova M (2019) Curcumin: novel treatment in neonatal hypoxic-ischemic brain injury. Front Physiol 10:1351. - https://www.ncbi.nlm.nih.gov/pubmed/31798458
  10. Feng D, Zou J, Su D, Mai H, Zhang S, Li P, Zheng X (2019) Curcumin prevents high-fat diet-induced hepatic steatosis in ApoE-/- mice by improving intestinal barrier function and reducing endotoxin and liver TLR4/NF-κB inflammation. Nutr Metab (Lond) 16:79. - https://www.ncbi.nlm.nih.gov/pubmed/31788011
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MitoPedia: mitObesity drugs

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TermAbbreviationDescription
AspirinAspirin is a widely applied drug that requires dosage adjusted to individual body mass. It is a non-selective COX inhibitor and exerts an effect on long-chain fatty acid transport into mitochondria.
CurcuminCurcumin has been shown to possess significant anti-inflammatory, anti-oxidant, anti-carcinogenic, anti-mutagenic, anti-coagulant and anti-infective effects. The protective effects of curcumin on rat heart mitochondrial injuries induced by in vitro anoxia–reoxygenation were evaluated by Xu et al 2013. It was found that curcumin added before anoxia or immediately prior to reoxygenation exhibited remarkable protective effects against anoxia–reoxygenation induced oxidative damage to mitochondria.
ElamipretideBendaviaBendavia (Elamipretide) was developed as a mitochondria-targeted drug against degenerative diseases, including cardiac ischemia-reperfusion injury. Clinical trials showed variable results. It is a cationic tetrapeptide which readily passes cell membranes, associates with cardiolipin in the mitochondrial inner membrane. Supercomplex-associated CIV activity significantly improved in response to elamipretide treatment in the failing human heart.
FlavonoidsFlavonoids are a group of bioactive polyphenols with potential antioxidant and anti-inflammatory effects, abundant in fruits and vegetables, and in some medicinal herbs. Flavonoids are synthesized in plants from phenylalanine. Dietary intake of flavonoids as nutraceuticals is discussed for targeting T2D and other degenerative diseases.
MelatoninaMTMelatonin (N-acetyl-5-methoxytryptamine, aMT) is a highly conserved molecule present in unicellular to vertebrate organisms. Melatonin is synthesized from tryptophan in the pinealocytes by the pineal gland and also is produced in other organs, tissues and fluids (extrapineal melatonin). Melatonin has lipophilic and hydrophilic nature which allows it to cross biological membranes. Therefore, melatonin is present in all subcellular compartments predominantly in the nucleus and mitochondria. Melatonin has pleiotropic functions with powerful antioxidant, anti-inflammatory and oncostatic effects with a wide spectrum of action particularly at the level of mitochondria. » MiPNet article
MetforminMetformin (dimethylbiguanide) is mainly known as an important antidiabetic drug which is effective, however, in a wide spectrum of degenerative diseases. It is an inhibitor of Complex I and glycerophosphate dehydrogenase complex.
RapamycinRapamycin is an inhibitor of the mammalian/mechanistic target of rapamycin, complex 1 (mTORC1). Rapamycin induces autophagy and dyscouples mitochondrial respiration. Rapamycin delays senescence in human cells, and extends lifespan in mice without detrimental effects on mitochondrial fitness in skeletal muscle.
ResveratrolResveratrol is a natural bioactive phenol prouced by several plants with antioxidant and anti-inflammatory effects. Dietary intake as nutraceutical is discussed for targeting mitochondria with a wide spectrum of action in degenerative diseases.
SpermidineSpermidine is a polycationic bioactive polyamine mainly found in wheat germ, soybean and various vegetables, involved in the regulation of mitophagy, cell growth and cell death. Like other caloric restriction mimetics, spermidine is effective in cardioprotection, neuroprotection and anticancer immunosuppression by preserving mitochondrial function and control of autophagy.
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MitoPedia:mitObesity drug