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Term	Abbreviation	Description
ISS-Waste Bottle		ISS-Waste Bottle, 2-liter, component of the ISS-Integrated Suction System.
Iconic symbols		Iconic symbols are used in ergodynamics to indicate more explicitely — compared to standard SI or IUPAC symbols — the quantity represented and some boundary conditions. This is particularly the case in normalized quantities (ratios of quantities). Iconic (or canonical) symbols help to clarify the meaning, are based on SI and IUPAC symbols as far as possible, and may be translated into more commonly used, practical symbols. Several ambiguities in SI and IUPAC symbols are eliminated by the systematic structure of iconic symbols, but it may be impossible to avoid all ambiguities, particulary when long (canonical) symbols are abbreviated in a particular context. Clarity is improved always by showing the unit of a quantity together with the symbol of the quantity. Iconic symbols cannot be identical with IUPAC symbols when a different definition is used — this would add to the confusion. For example, the IUPAC symbols n_B [mol] and V_B [m³] denote amount and volume of B. Consequently, it should be expected, that the symbol Q_B indicates charge of B [C]. However, the IUPAC symbol Q_B is used for particle charge per ion B [C·x^-1]. This prohibits a consistent definition of Q_B as a potential iconic symbol for charge carried by a given quantity of ions B with unit [C], instead of particle charge per ion B with unit [C·x^-1]. Hence, the conventional ambigous system forces compatible iconic symbols to be more complicated, using Q_elB [C] and Q_NB [C·x^-1] to distinguish charge of B from charge per elementary B. Q_nB [C·mol^-1] is charge per molar amount of B.
Illumination	F10	The chambers of the Oroboros O2k are illuminated by an internal LED. The illumination is switched on and off in DatLab during the experiment by pressing [F10]. This illumination must be distinguished from light introduced into the chambers by LEDs for the purpose of spectrophotometric and fluorometric measurements. For these, the internal illumination must be switched off.
Illumination on/off	F10	The illumination in both chambers is switched on/off.
Impact factor	IF	Impact factor is a measure of a scientific journal's citations per publication. The Journal Citation Reports, maintained by Clarivate Analytics, provides the calculated impact factors. The IF is frequently used as an indicator of a journal's importance or prestige, which is nowadays increasingly contested.
Improvement score	RIS	The relative improvement score, RIS, provides a measure of improvement of a trait from a value measured at baseline, B, to a value measured after treatment, T, expressing the total improvement, T-B, in relation to the theoretical scope of improvement and the level of the trait observed at baseline. 'RIS incorporates the concept of diminishing returns and consideres maintaining a high value of a trait as an improvement relative to the potential loss.
In vitro diagnostic medical device	IVD	A medical device is an in vitro diagnostic medical device (IVD) if it is a reagent, calibrator, control material, kit, specimen receptacle, software, instrument, apparatus, equipment or system, whether used alone or in combination with other diagnostic goods for in vitro use.
Incident light		The term incident light is used for a beam of light falling upon a surface.
Inclusion criteria		The Inclusion criteria are based on key features of the target population that the researchers will use to answer their question. These criteria should identify the study population in a consistent, reliable, uniform, and objective manner. With the Exclusion criteria, this factor must be a cofounder for the outcome parameter
Indian Academy of Pediatrics Growth Charts Committee 2015 Indian Pediatr
Inorganic phosphate	P_i	Inorgnic phosphate (P_i) is a salt of phosphoric acid. In solution near physiological pH, the species HPO₄^2- and H₂PO₄^- dominate. See also: Phosphate carrier (Pic).
Inside the O2k		A glance inside the Oroboros O2k
Install Oroboros protocol package		The standard Instrumental and SUIT DL-Protocols package is automatically implemented with the simple DatLab programme installation. We recommend a 'clean install': rename your previous DatLab programme subdirectory (e.g. C:\DatLab_OLD). Updates and newly developed DL protocols can be simply downloaded by clicking on [Protocols]\Install Oroboros protocol package.
Instrumental: Browse DL-Protocols and templates		Instrumental DL-Protocols (DLP) including DatLab example traces, instructions, brief explanatory texts, links to relevant pages and templates for data evaluation can be browsed from inside DatLab 7.4. Click on menu [Protocols]\Instrumental: Browse DL-Protocols and templates to open a folder with all the DL-Protocols and templates for cleaning, calibration, and background determination provided with the DatLab 7.4. Select a sub-directory and open an DL-Protocol and/or template as desired.
Integration time		Integration time is the time taken to scan a single full range spectrum using photodiode arrays. It is equivalent to the exposure time for a camera. The shortest integration time defines the fastest response time of a spectrophotometer. Increasing the integration time increases the sensitivity of the device. The white balance or balance and subsequent measurements must always be carried out at the same integration time.
Intensive quantity		Intensive quantities are partial derivatives of an extensive quantity by the advancement, d_trξ_X, of an energy transformation tr; example: Force. In contrast to extensive quantities which pertain to the entire system and are additive, extensive quantities 'take well defined values at each point of the system' (Prigogine 1967 Interscience) and are non-additive. Intensive and extensive quantities can be easily discriminated by the units, e.g. [J] for the extensive quantity, in contrast to [J·mol^-1] for the corresponding intensive quantity. In the general definition of thermodynamics, intensive quantities are not distinguished from specific quantities (Cohen 2008 IUPAC Green Book). Ergodynamics emphasizes the contrast between specific quantities which are extensive quantities normalized for a variable expressing system size (mass, volume of the system, amount of substance in a system) and intensive quantities which are normalized for the motive unit of a transformation (mass exchanged, volume change of the system, amount of substance reacting in a system; Gnaiger 1993 Pure Appl Chem). Intensive and specific quantities are both non-additive, take well defined values at each point of the system, and both corresponding quantities are expressed in identical units, e.g. the intensive quantity Gibbs force of a catabolic reaction (such as oxidation; 0 = -1 Glc - 6 O₂ + 6 CO₂ + 6 H₂O), Δ_kG_Glc [kJ·mol^-1], and the specific quantity Gibbs energy per mole glucose contained in a system, G_Glc [kJ·mol^-1] (with respect to an arbitrarily defined reference state, such as the reference state of formation or combustion).
Interlaboratory comparison		An interlaboratory comparison is the organization, performance and evaluation of measurements or tests on the same or similar items by two or more laboratories in accordance with predetermined conditions.
Internal flow	I_i [MU·s^-1]	Within the system boundaries, irreversible internal flows, I_i,—including chemical reactions and the dissipation of internal gradients of heat and matter—contribute to internal entropy production, d_iS/dt. In contrast, external flows, I_e, of heat, work, and matter proceed reversibly across the system boundaries (of zero thickness). Flows are expressed in various formats per unit of time, with corresponding motive units [MU], such as chemical [mol], electrical [C], mass [kg]. Flow is an extensive quantity, in contrast to flux as a specific quantity.
Internal-energy	U [J]	Internal-energy, U [J], can neither be destroyed nor created (first law of thermodynamics: d_iU/dt = 0). Note that internal (subscript i), as opposed to external (subscript e), must be distinguished from "internal-energy", U, which contrasts with "Helmholtz energy", A, as enthalpy, H, contrasts with Gibbs energy, G.
International Mito Patients (IMP)	IMP	The International Mito Patients is a network of national patient organizations involved in mitochondrial disease. Mitochondrial disease is a rare disease with a limited number of patients per country. The national patient organizations which are a member of IMP each are active and powerful in their own countries. By joining forces IMP can represent a large group of patients and as such be their voice on an international level.
International Society for Mountain Medicine	ISMM	The International Society for Mountain Medicine is an interdisciplinary society comprising about xx members worldwide. Its purpose is ..
International Society on Oxygen Transport to Tissue	ISOTT	The International Society on Oxygen Transport to Tissue is an interdisciplinary society comprising about 250 members worldwide. Its purpose is to further the understanding of all aspects of the processes involved in the transport of oxygen from the air to its ultimate consumption in the cells of the various organs of the body. Founded in 1973, the society has been the leading platform for the presentation of many of the technological and conceptual developments within the field both at the meetings themselves and in the proceedings of the society.
International Standard Serial Number	ISSN	The International Standard Serial Number, ISSN, is a code used to identify periodical publications, independent of which media are used (print and/or electronic). - Bioenergetics Communications, BEC: ISSN 2791-4690
International System of Units	SI	The International System of Units (SI) is the modern form of the metric system of units for use in all aspects of life, including international trade, manufacturing, security, health and safety, protection of the environment, and in the basic science that underpins all of these. The system of quantities underlying the SI and the equations relating them are based on the present description of nature and are familiar to all scientists, technologists and engineers. The definition of the SI units is established in terms of a set of seven defining constants. The complete system of units can be derived from the fixed values of these defining constants, expressed in the units of the SI. These seven defining constants are the most fundamental feature of the definition of the entire system of units. These particular constants were chosen after having been identified as being the best choice, taking into account the previous definition of the SI, which was based on seven base units, and progress in science (p. 125).
International Union of Pure and Applied Chemistry, IUPAC	IUPAC	The International Union of Pure and Applied Chemistry (IUPAC) celebrated in 2019 the 100^th anniversary, which coincided with the International Year of the Periodic Table of Chemical Elements (IYPT 2019). IUPAC {Quote} notes that marking Mendeleev's achievement will show how the periodic table is central to connecting cultural, economic, and political dimensions of global society “through a common language” {end of Quote} (Horton 2019). 2019 is proclaimed as the International Year of the Periodic Table of Chemical Elements (IYPT 2019). For a common language in mitochondrial physiology and bioenergetics, the IUPAC Green book (Cohen et al 2008) is a most valuable resource, which unfortunately is largely neglected in bioenergetics textbooks. Integration of open systems and non-equilibrium thermodynamic approaches remains a challenge for developing a common language (Gnaiger 1993; BEC 2020.1).
International oxygraph course	IOC	International Oxygraph Course (IOC), see O2k-Workshops.
Internationale Gesellschaft fuer Regenerative Mitochondrien-Medizin	IGRMM e.V.	Organizer of Klinische MitochondrienMedizin und Umweltmedizin 2015 Klinische MitochondrienMedizin und Umweltmedizin 2016 Klinische MitochondrienMedizin und Umweltmedizin 2017 Klinische MitochondrienMedizin und Umweltmedizin 2018
Interpolate points		Select Interpolate points in the Mark information window to interpolate all data points in the marked section of the active graph. See also Delete points and Restore points or Recalculate slope.
Intracellular oxygen	p_O2,i	Physiological, intracellular oxygen pressure is significantly lower than air saturation under normoxia, hence respiratory measurements carried out at air saturation are effectively hyperoxic for cultured cells and isolated mitochondria.
Intrinsic fluorophores		An Intrinsic flourophore is a naturally occurring fluorophore of which NADH, aromatic amino acids and flavins are examples.
Ion-Selective Electrode TPP+ and Ca2+		Ion-Selective Electrode TPP+ and Ca2+: ISE with 6 mm outer diameter shaft, for Stopper\white PVDF\angular Shaft\side+6.2+2.6 mm Port. O2k-TPP+ ISE-Module: 2 ISE.
Ionomycin	Imy	Ionomycin (Imy) is a ionophore used to raise intracellular [Ca²⁺].
Isocitrate		isocitrate, C₆H₅O₇^-3, is a tricarboxylic acid trianion, intermediate of the TCA cycle, obtained by isomerization of citrate. The process is catalyzed by aconitase, forming the enzyme-bound intermediate cis-aconitate.
Isocitrate dehydrogenase	IDH	Isocitrate dehydrogenase forms 2-oxoglutarate from isocitrate in the TCA cycle.
Isolated mitochondria	imt	Isolated mitochondria, imt, are mitochondria separated from a tissue or cells by breaking the plasma membranes and attachments to the cytoskeleton, followed by centrifugation steps to separate the mitochondria from other components.
Isolated system		The boundaries of isolated systems are impermeable for all forms of energy and matter. Changes of isolated systems have exclusively internal origins, e.g., internal entropy production, d_iS/dt, internal formation of chemical species i which is produced in a reaction r, d_in_i/dt = d_rn_i/dt. In isolated systems some internal terms are restricted to zero by various conservation laws which rule out the production or destruction of the respective quantity.
Isomorphic		The term isomorphic refers to quantities which have identical or similar form, shape, or structure. In mathematics, an isomorphism defines a one-to-one correspondence between two mathematical sets. In ergodynamics, isomorphic quantities are defined by equations of identical form. If isomorphic quantities are not expressed in identical units, then these quantities are expressed in different formats which can be converted to identical untis. Example: electric force [V=J/C] and chemical force [Jol=J/mol] are ismorphic forces; the electrical format [J/C] can be converted to the chemical format [J/mol] by the Faraday constant. Units not only give meaning to the numerical value of a quantity, but units provide also an abbreviated common language to communicate and compare isomorphic quantities. In irreversible thermodynamics, isomorphic forces are referred to as generalized forces.
Japanese Society of Mitochondrial Research and Medicine	J-mit	The Japanese Society of Mitochondrial Research and Medicine (J-mit) was founded to share the latest knowledge on mitochondrial research. J-mit is the biggest Asian society of mitochondrial research and medicine and is a member of ASMRM.
Jmax	J_max	J_max is the maximum pathway flux (e.g. oxygen flux) obtained at saturating substrate concentration. J_max is a function of metabolic state. In hyperbolic ADP or oxygen kinetics, J_max is calculated by extrapolation of the hyperbolic function, with good agreement between the calculated and directly measured fluxes, when substrate levels are >20 times the c₅₀ or p₅₀.
Journal indexing		Journal indexing allows publications to be found on search tools/databases. Each database might have different criteria of inclusion.
Journal issue		An issue of a journal or periodical is a number, which typically indicates how many times a volume of the journal has been published in sequence.
Journal publication		In most cases journal publication {Quote} will not be affected by posting a preprint. However, there are some publishers that do not consider papers that have already appeared online. We strongly recommend that you check all journals that you might submit to in advance {end of Quote}. A list of academic journals by preprint policy is available.
Journal volume		The volume of a journal or periodical is a number, which in many cases indicates the sequential number of years the journal has been published. Alternatively, the volume number may indicate the current year, independent of the year in which the journal published its first volume. A volume may be subdivided into issues.
Kelvin	K	The kelvin, symbol K, is the SI unit of thermodynamic temperature. It is defined by taking the fixed numerical value of the Boltzmann constant k to be 1.380 649 × 10⁻²³ when expressed in the unit J x^-1 K⁻¹.
Keyboard shortcuts - DatLab		DatLab provides several keyboard shortcuts to allow for quick access to many functions and settings without using a mouse.
Keywords-MitoPedia in BEC		Keywords—MitoPedia is the concept to link keywords in articles published in Bioenergetics Communications (BEC) to MitoPedia terms. Authors should consider the message in the selected keywords. Provide consistent definitions of your keywords by linking them to MitoPedia. Extend MitoPedia entries critically by your contributions. The BEC editorial team will hyperlink your keywords with MitoPedia, and a reference to your BEC publication will be generated automatically from the MitoPedia term to your publication. With your contributions, BEC elevates keywords to terms with meaning. Your article gains visibility.
Kilogram	kg	The kilogram, symbol kg, is the SI unit of mass. It is defined by taking the fixed numerical value of the Planck constant h to be 6.626 070 15 × 10⁻³⁴ when expressed in the unit J s, which is equal to kg m² s⁻¹, where the meter and the second are defined in terms of c and Δν_Cs.
Korean Society of Mitochondrial Research and Medicine	KSMRM	The Korean Society of Mitochondrial Research and Medicine (KSMRM) is a member of ASMRM.
Kynurenine hydroxylase		Kynurenine hydroxylase (kynurenine 3-monooxygenase) is located in the outer mitochondrial membrane. Kynurenine hydroxylase catalyzes the chemical reaction: L-kynurenine + NADPH + H⁺ + O₂ ↔ 3-hydroxy-L-kynurenine + NADP⁺ + H₂O Kynurenine hydroxylase belongs to the family of oxidoreductases acting on paired donors, with O₂ as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O₂ with NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor. This enzyme participates in tryptophan metabolism. It employs one cofactor, FAD.
L/E coupling-control ratio	L/E	The L/E coupling-control ratio is the flux ratio of LEAK respiration over ET capacity, as determined by measurement of oxygen consumption in L and E sequentially. The L/E coupling-control ratio is an index of uncoupling or dyscoupling at constant ET-capacity. L/E increases with uncoupling from a theoretical minimum of 0.0 for a fully coupled system, to 1.0 for a fully uncoupled system.

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