DK Copenhagen Dela F

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DK Copenhagen Dela F

OROBOROS O2k-Network

O2k-Network
O2k-Network Lab University of Copenhagen

Center for Healthy Aging

Faculty Of Health Sciences

Department of Biomedical Sciences

Address Blegdamsvej 3B, DK-2200
City Copenhagen
State/Prov
Country Denmark
Weblink healthy aging
Contact Larsen Steen, Dela Flemming
Team Bach Jeppe, Beck Thomas, Dohlmann Tine, Hansen NC, Helge Joern W, Gram Martin, Kraunsoee Regitze, Lindemose Soeren, Neigaard-Hansen C, Soendergaard Stine, Taulo Lund M
Team previous Boushel Robert C, Rodriguez-Juarez Felix, Stride Nis, Rabol Rasmus, Skovbro Mette, Hey-Mogensen Martin, Yokota Takashi
Status 9 Power-O2k 2004-
OROBOROS Events IOC95, MiP2014, MiP2013, IOC75, IOC74, IOC61, IOC59, IOC51, IOC47, IOC31, IOC30, IOC28
Topics


O2k-Publications

Published Reference
Soendergaard 2016 Eur J Sport Sci 2016 Søndergård SD, Dela F, Helge JW, Larsen S (2016) Actovegin, a non-prohibited drug increases oxidative capacity in human skeletal muscle. Eur J Sport Sci [Epub ahead of print].
Lund 2016 J Physiol 2016 Lund MT, Kristensen M, Hansen M, Tveskov L, Floyd AK, Støckel M, Vainer B, Poulsen SS, Helge JW, Prats C, Dela F (2016) Hepatic mitochondrial oxidative phosphorylation is normal in obese patients with and without type 2 diabetes. J Physiol [Epub ahead of print].
Gram 2015 J Physiol 2015 Gram M, Vigelsø A, Yokota T, Helge JW, Dela F, Hey-Mogensen M (2015) Skeletal muscle mitochondrial H2O2 emission increases with immobilization and decreases after aerobic training in young and older men. J Physiol 593:4011-27.
Guadalupe-Grau 2015 J Sports Sci 2015 Guadalupe-Grau A, Plenge U, Helbo S, Kristensen M, Andersen PR, Fago A, Belhage B, Dela F, Helge JW (2015) Effects of an 8-weeks erythropoietin treatment on mitochondrial and whole body fat oxidation capacity during exercise in healthy males. J Sports Sci 33:570-8.
Christiansen 2015 J Vet Med Sci 2015 Christiansen LB, Dela F, Koch J, Yokota T (2015) Tissue-specific and substrate-specific mitochondrial bioenergetics in feline cardiac and skeletal muscles. J Vet Med Sci 77:669-75.
Dahl 2015 Acta Physiol (Oxf) 2015 Dahl R, Larsen S, Dohlmann TL, Qvortrup K, Helge JW, Dela F, Prats C (2015) Three dimensional reconstruction of the human skeletal muscle mitochondrial network as a tool to assess mitochondrial content and structural organization. Acta Physiol (Oxf) 213:145-55.
Christiansen 2015 Am J Physiol Heart Circ Physiol 2015 Christiansen LB, Dela F, Koch J, Hansen CN, Leifsson PS, Yokota T (2015) Impaired cardiac mitochondrial oxidative phosphorylation and enhanced mitochondrial oxidative stress in feline hypertrophic cardiomyopathy. Am J Physiol Heart Circ Physiol 308:H1237-47.
Hey-Mogensen 2015 J Physiol 2015 Hey-Mogensen M, Gram M, Jensen MB, Lund MT, Hansen CN, Scheibye-Knudsen M, Bohr VA, Dela F (2015) A novel method for determining human ex vivo submaximal skeletal muscle mitochondrial function. J Physiol 593:3991-4010.
Soltysinska 2014 PLoS One 2014 Soltysinska E, Bentzen BH, Barthmes M, Hattel H, Thrush AB, Harper ME, Qvortrup K, Larsen FJ, Schiffer TA, Losa-Reyna J, Straubinger J, Kniess A, Thomsen MB, Brüggemann A, Fenske S, Biel M, Ruth P, Wahl-Schott C, Boushel RC, Olesen SP, Lukowski R (2014) KCNMA1 encoded cardiac BK channels afford protection against ischemia-reperfusion injury. PLoS One 9:e103402.
Gram 2014 Exp Gerontol 2014 Gram M, Vigelsoe A, Yokota T, Hansen CN, Helge JW, Hey-Mogensen M, Dela F (2014) Two weeks of one-leg immobilization decreases skeletal muscle 2 respiratory capacity equally in young and elderly men. Exp Gerontol 58C:269-78.
Larsen 2014 Anal Biochem 2014 Larsen S, Kraunsøe R, Gram M, Gnaiger E, Helge JW, Dela F (2014) The best approach: homogenization or manual permeabilization of human skeletal muscle fibers for respirometry? Anal Biochem 446:64-8.
Guadalupe-Grau 2014 J Sports Sci 2014 Guadalupe-Grau A, Plenge U, Helbo S, Kristensen M, Andersen PR, Fago A, Belhage B, Dela F, Helge JW (2014) Effects of an 8-weeks erythropoietin treatment on mitochondrial and whole body fat oxidation capacity during exercise in healthy males. J Sports Sci 26:1-9.
Larsen 2014 World J Diabetes 2014 Larsen S, Skaaby S, Helge JW, Dela F (2014) Effects of exercise training on mitochondrial function in patients with type 2 diabetes. World J Diabetes 5:482-92.
Svendsen 2014 Thesis 2014 Svendsen PF (2014) Metabolic aspects of polycystic ovary syndrome and obesity. Thesis Copenhagen University Hospital:38 pp.
Larsen 2014 Biochim Biophys Acta 2014 Larsen S, Díez-Sánchez C, Rabøl R, Royo IA, Dela F, Helge JW (2014) Increased intrinsic mitochondrial function in humans with mitochondrial haplogroup H. Biochim Biophys Acta 1837:226-31.
Larsen 2013 J Am Coll Cardiol 2013 Larsen S, Stride N, Hey-Mogensen M, Hansen CN, Bang LE, Bundgaard H, Nielsen LB, Helge JW, Dela F (2013) Simvastatin effects on skeletal muscle: relation to decreased mitochondrial function and glucose intolerance. J Am Coll Cardiol 61:44-53.
Kristensen 2013 PLoS One 2013 Kristensen JM, Larsen S, Helge JW, Dela F, Wojtaszewski JFP (2013) Two weeks of metformin treatment enhances mitochondrial respiration in skeletal muscle of AMPK kinase dead but not wild type mice. PLoS One 8:e53533.
Stride 2013 Eur J Heart Fail 2013 Stride N, Larsen S, Hey-Mogensen M, Sander K, Lund JT, Gustafsson F, Kober L, Dela F (2013) Decreased mitochondrial oxidative phosphorylation capacity in the human heart with left ventricular systolic dysfunction. Eur J Heart Fail 15:150-7.
Larsen 2012 Acta Physiol (Oxf) 2012 Larsen S, Hey-Mogensen M, Rabol R, Stride N, Helge JW, Dela F (2012) The influence of age and aerobic fitness: Effects on mitochondrial respiration in skeletal muscle. Acta Physiol (Oxf) 205:423-32.
Larsen 2012 J Physiol 2012 Larsen S, Nielsen J, Neigaard Nielsen C, Nielsen LB, Wibrand F, Stride N, Schroder HD, Boushel RC, Helge JW, Dela F, Hey-Mogensen M (2012) Biomarkers of mitochondrial content in skeletal muscle of healthy young human subjects. J Physiol 590:3349-60.
Stride 2012 Front Physiol 2012 Stride N, Larsen S, Treebak JT, Hansen CN, Hey-Mogensen M, Speerschneider T, Jensen TE, Jeppesen J, Wojtaszewski JF, Richter EA, Køber L, Dela F (2012) 5'-AMP activated protein kinase is involved in the regulation of myocardial β-oxidative capacity in mice. Front Physiol 3:33.
Plenge 2012 Endocrine Abstracts 2012 Plenge U, Guadeloupe-Grau A, Andersen P, Carsten L, Dela F, Pott F, Jørn H, Belhage B, Boushel RC (2012) Recombinant erythropoietin treatment enhances mitochondrial function in human skeletal muscle. Endocrine Abstracts 29 P302 .
Plenge 2012 Front Physiol 2012 Plenge U, Belhage B, Guadalupe-Grau A, Andersen PR, Lundby C, Dela F, Stride N, Pott FC, Helge JW, Boushel RC (2012) Erythropoietin treatment enhances muscle mitochondrial capacity in humans. Front Physiol 3:50.
Skovbro 2011 J Appl Physiol 2011 Skovbro M, Boushel RC, Hansen CN, Helge JW, Dela F (2011) High-fat feeding inhibits exercise-induced increase in mitochondrial respiratory flux in skeletal muscle. J Appl Physiol 110:1607-14.
Larsen 2011 Acta Physiol (Oxf) 2011 Larsen S, Kristensen JM, Stride N, Wojtaszewski JF, Helge JW, Dela F (2011) Skeletal muscle mitochondrial respiration in AMPKα2 kinase-dead mice. Acta Physiol (Oxf) 205: 314-320.
Naimi 2011 Clin Physiol Funct Imaging 2011 Naimi AI, Bourbeau J, Perrault H, Baril J, Wright-Paradis C, Rossi A, Taivassalo T, Sheel AW, Rabøl R, Dela F, Boushel RC (2011) Altered mitochondrial regulation in quadriceps muscles of patients with COPD. Clin Physiol Funct Imaging 31:124-31.
Ara 2011 Int J Obes 2011 Ara I, Larsen S, Stallknecht B, Guerra B, Morales-Alamo D, Andersen JL, Ponce-González JG, Guadalupe-Grau A, Galbo H, Calbet JA, Helge JW (2011) Normal mitochondrial function and increased fat oxidation capacity in leg and arm muscles in obese humans. Int J Obes 35: 99-108.
Larsen 2011 Diabetologia 2011 Larsen S, Stride N, Hey-Mogensen M, Hansen CN, Andersen JL, Madsbad S, Worm D, Helge JW, Dela F (2011) Increased mitochondrial substrate sensitivity in skeletal muscle of patients with type 2 diabetes. Diabetologia 54: 1427-1436.
Rabol 2011 Eur J Endocrinol 2011 Rabol R, Svendsen PF, Skovbro M, Boushel RC, Schjerling P, Nilas L, Madsbad S, Dela F (2011) Skeletal muscle mitochondrial function in polycystic ovarian syndrome. Eur J Endocrinol 165:631-7.
Kraunsoee 2010 J Physiol 2010 Kraunsøe R, Boushel RC, Hansen CN, Schjerling P, Qvortrup K, Støckel M, Mikines KJ, Dela F (2010) Mitochondrial respiration in subcutaneous and visceral adipose tissue from patients with morbid obesity. J Physiol 588:2023-32.
Rabol 2010 Diabetes Obes Metab 2010 Rabol R, Boushel RC, Almdal T, Hansen CN, Ploug T, Haugaard SB, Prats C, Madsbad S, Dela F (2010) Opposite effects of pioglitazone and rosiglitazone on mitochondrial respiration in skeletal muscle of patients with type 2 diabetes. Diabetes Obes Metab 12:806-14.
Rabol 2010 J Clin Endocrinol Metab 2010 Rabol R, Larsen S, Hojberg PM, Almdal T, Boushel RC, Haugaard SB, Andersen JL, Madsbad S, Dela F (2010) Regional anatomic differences in skeletal muscle mitochondrial respiration in type 2 diabetes and obesity. J Clin Endocrinol Metab 95:857-63.
Larsen 2009 Diabetologia 2009 Larsen S, Ara I, Rabøl R, Andersen JL, Boushel RC, Dela F, Helge JW (2009) Are substrate use during exercise and mitochondrial respiratory capacity decreased in arm and leg muscle in type 2 diabetes? Diabetologia 52:1400-8.
Raboel 2009 J Clin Endocrinol Metabol 2009 Rabøl R, Højberg PM, Almdal T, Boushel R, Haugaard SB, Madsbad S, Dela F (2009) Effect of hyperglycemia on mitochondrial respiration in type 2 diabetes. J Clin Endocrinol Metabol 94:1372-78.
Rabol 2009 Diabetes Obes Metab 2009 Rabol R, Hojberg PM, Almdal T, Boushel RC, Haugaard SB, Madsbad S, Dela F (2009) Improved glycaemic control decreases inner mitochondrial membrane leak in type 2 diabetes. Diabetes Obes Metab 11:355-60.
Rabol 2009 Metabolism 2009 Rabøl R, Svendsen PF, Skovbro M, Boushel RC, Haugaard SB, Schjerling P, Schrauwen P, Hesselink MK, Nilas L, Madsbad S, Dela F (2009) Reduced skeletal muscle mitochondrial respiration and improved glucose metabolism in nondiabetic obese women during a very low calorie dietary intervention leading to rapid weight loss. Metabolism 58:1145-52.
Huetter 2007 Aging Cell 2007 Hütter E, Skovbro M, Lener B, Prats C, Rabol R, Dela F, Jansen-Dürr P (2007) Oxidative stress and mitochondrial impairment can be separated from lipofuscin accumulation in aged human skeletal muscle. Aging Cell 6:245-56.
Boushel 2007 Diabetologia 2007 Boushel RC, Gnaiger E, Schjerling P, Skovbro M, Kraunsoee R, Dela F (2007) Patients with Type 2 diabetes have normal mitochondrial function in skeletal muscle. Diabetologia 50:790-6.
Rabol 2006 Appl Physiol Nutr Metab 2006 Rabol R, Boushel RC, Dela F (2006) Mitochondrial oxidative function and type 2 diabetes. Appl Physiol Nutr Metab 31:675-83.


O2k-Abstracts

Published Reference
Soendergaard 2016 Abstract IOC109 2016 Soendergaard SD (2016) Acute exposure of human muscle fibers to EPO or Actovegin has a marked effect on the mitochondrial respiratory capacity. Mitochondr Physiol Network 21.01.
Larsen 2014 Abstract MiP2014 2014 The effect of high intensity training on mitochondrial fat oxidation in skeletal muscle and subcutaneous adipose tissue.
Dohlmann 2014 Abstract MiP2014 2014 Mitochondrial adaptations to high-intensity training in young and elderly men and women.
Dela 2013 Abstract MiP2013 2013 Dela F (2013) Glucose tolerance and skeletal muscle coenzyme Q(10). Mitochondr Physiol Network 18.08.
Dohlmann 2013 Abstract IOC75 2013 Dohlmann T (2013) Effects of high-intense interval training on mitochondrial respiratory capacity. Mitochondr Physiol Network 18.03.
Larsen S 2013 Abstract MiP2013 2013 Larsen S, Dohlmann TL, Hindsø M, Dela F, Helge JW (2013) High intensity training decreases mitochondrial ADP sensitivity in human adipose and skeletal muscle tissue. Mitochondr Physiol Network 18.08.
Harper 2012 Abstract Bioblast 2012 Harper ME, Yin H, Pasut A, Soleimani VD, Bentzinger CF, Antoun G, Thorn S, Seale P, Fernando P, Van IJcken W Frank Grosveld F, Dekemp RA, Boushel RC, Rudnicki MA (2012) Metabolic effects of microRNA-133 and its antagomir in mice. Mitochondr Physiol Network 17.12.
Dela MiP2010 2010 Kraunsoee R, Boushel RC, Hansen CN, Schjerling P, Qvortrup K, Stoecke M, Mikines KJ, Dela F (2010) Mitochondrial respiration in subcutaneous and visceral adipose tissue from patients with morbid obesity. Mitochondr Physiol Network 15.6:50-1.

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