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...but increases mitochondrial respiration under conditions of mild oxidative stress. Cells 8:E1289. ...he disease-causing R94Q mutation in MFN2 are more susceptible to oxidative stress, which causes uncoupling of respiration and ATP production possibly by a le

...treatment with the mitochondrial-targeted peptide SS-31 reduces oxidative stress and improves muscle function in aged mice. However, whether long-term treat |injuries=Oxidative stress;RONS

...ld determine the molecular mechanisms [1] further explaining the effect of stress in certain disorders, viz. aging, hypertension, generalized anxiety disorde ...could be spatio-temporal changes that the genome might undergo during such stress conditions which could possibly explain systems biological reasons that lin

...xidative stress, reactive oxygen species (ROS) and endoplasmatic reticulum stress playing a major role [1]. Mitochondrial dysfunction seems to be crucial in

...effects of arsenic trioxide on spermatogonia are associated with oxidative stress, mitochondrial dysfunction, autophagy and metabolomic alterations. Ecotoxic .... We concluded that ATO was toxic to GC-1 spg cells via inducing oxidative stress, mitochondrial dysfunction and autophagy as well as the disruption of norma

...and compromise cell viability. To prevent or reduce ROS-induced oxidative stress, bacteria utilize different ROS defense mechanisms, of which ROS scavenging |keywords=Bacteria, Oxidative stress, Reactive oxygen species, Redox enzymes, Terminal oxidases

...This prompted us to study the effects of acute inflammation and oxidative stress on the morphology, transport, and function of mitochondria in axons. ...t effects: inflammation mostly reducing retrograde transport and oxidative stress slightly enhancing retrograde transportation.

...their contribution in chronic kidney disease progression through oxidative stress. Front Physiol 12:627837. https://doi.org/10.3389/fphys.2021.627837 ...of ROS and/or decreased antioxidants defense activity results in oxidative stress (OS), which leads to oxidative damage that affects several cellular compone

{{#ask:[[Category:Abstracts]] [[Additional label::MiP2013]] [[Stress::Hypoxia]]

|?Stress

...ioenergetics and provides preconditioning for protection against oxidative stress. Free Radic Biol Med 93:177-89. ...f Rev-erbα with mitochondrial homeostasis and protection against oxidative stress.

...ssociated impairments in mitochondrial ADP sensitivity contribute to redox stress in senescent human skeletal muscle. Cell Rep 22:2837–48. ...₂O₂ emission and contributes to age-associated redox stress.

...te MJ, Journot BJ, McKinley TO, Buckwalter JA, Martin JA (2013) Mechanical stress and ATP synthesis are coupled by mitochondrial oxidants in articular cartil |keywords=Articular Cartilage, Oxidants, Reactive Oxygen Species, Mechanical stress, Glycolysis

...protein adducts, due to lipid peroxidation following DOX-induced oxidative stress, was significantly attenuated by SFN treatment. The respiratory function of |injuries=Oxidative stress;RONS

...warth FC, Raza H (2021) Effect of aspirin on mitochondrial dysfunction and stress in the pancreas and heart of Goto-Kakizaki diabetic rats. Life (Basel) 11:9 ...redox homeostasis could be the key target in the improvement of oxidative-stress-dependent alterations in mitochondrial functions which, in turn, facilitate

...ivation and reperfusion (OGD/R)-induced apoptosis and the activation of ER stress response. Meanwhile, FtMt overexpression rescued OGD/R-induced mitochondria

...hao M, Yuan F, Liu F (2020) Polydatin attenuates cadmium-induced oxidative stress via stimulating SOD activity and regulating mitochondrial function in ''Mus ...ated. The larvae were exposed to Cd and/or PD, subsequently, the oxidative stress status, mitochondria activity, oxidative phosphorylation efficiency, and su

|keyword=Mitochondrial alterations after traumatic stress and in psychiatric disorders

Cellular Stress Group

...of whole animal performance. Better understanding of physiological thermal stress cascades will help to improve forecasts of how changing environmental tempe

...eath. Taken together these findings suggest that oxidative and nitrosative stress cooperatively play an important role in driving LHON pathology when excess |keywords=Nitric oxide, LHON, Oxidative and nitrosative stress, PBMC

|topics=nerve, AMPK, sensor neuron, nutrient stress, diabetes, neuropathy

...muscle, leading to impaired mitochondrial function and increased oxidative stress. |injuries=Oxidative stress;RONS

...1993) Mitochondria as a source of reactive oxygen species during reductive stress in rat hepatocytes. Am J Physiol 264:C961-7. ...ical formation by complex III is involved in cell killing during reductive stress. In support of this hypothesis, myxothiazol reduced rates of cell killing a

...evaluating mechanistic relationships between TDP-43 aggregation, oxidative stress and cellular changes in DHA-related proteins. ...since human neurons exhibited losses of FADS2 and drebrin after oxidative stress. These features (drebrin loss and FADS2 alterations) were also produced by

...metabolic syndrome, through a mechanism involving prevention of oxidative stress by mitochondrial homeostasis regulation. In conclusion, this study highligh |keywords=Autophagy, Diabetes, Mitochondria, Obesity, Oxidative stress, MEF

signs of oxidative stress-decreased alpha-tocopherol/cholesterol in the plasma (''p'' oxidative stress. Administration of simvastatin (10 mg/kg) to the

...role of mitochondria-derived ROS in the development of systemic oxidative stress during exercise as well as skeletal muscle diseases such as exertional rhab |keywords=high-resolution respirometry; horse; oxidative stress; skeletal muscle.

...erne Szappanos H, Tull D, Yeoh GC, Hool LC, Filipovska A, Rackham O (2019) Stress signaling and cellular proliferation reverse the effects of mitochondrial m ...on reduces the rate of protein synthesis without eliciting a mitochondrial stress response. Consequently, the rate of translation cannot be recovered and thi

...risk, although more research on these pathways in the context of traumatic stress is needed. Given that many of these mechanisms are closely intertwined, fut

...(2015) Low oxygen alters mitochondrial function and response to oxidative stress in human neural progenitor cells. PeerJ 3:e1486. ...itions, however, when exposed to external agents known to induce oxidative stress, greater susceptibility to DNA damage was observed. Our findings indicate t

...ncluded that CoQ10 may protect astrocytes through suppression of oxidative stress, prevention of mitochondrial dysfunction, blockade of mitochondria-mediated |injuries=Oxidative stress;RONS

...gly, measurements of plasmatic oxidative markers indicated lower oxidative stress in blood of the zebra finch compared to a size-matched mammalian model, the ...tive oxygen species (ROS) production. Interestingly, since blood oxidative stress was lower for our avian model compared to a size-matched mammalian, our res

...mpromised and to become less resilient under continuous stress. Meanwhile, stress and inflammation have been linked to the activation of the tryptophan (Trp)

...in Ppif(-/-) mice increases stability of brain mitochondria against Ca(2+) stress. Arch Biochem Biophys 579:40-6. ...mitochondrial function and increases mitochondria stability against Ca(2+) stress.

...function, the mitochondrial permeability transition pore and on oxidative stress in more detail, we used the aging model ''Podospora anserina'' that lacks e ...ondrial dysfunction, Mitochondrial permeability transition pore, Oxidative stress

...mage were evaluated. Our results revealed species specificity in metabolic stress responses. An increase of ''ṀO₂'' was noted in cardinal tetra ...abolic rate, Mitochondria respiration, Ornamental Amazon fishes, Oxidative stress, Reactive oxygen species

...gest that during the early minutes of reperfusion, PostC reduces oxidative stress and inhibits mPTP opening, independent of alteration of oxidative phosphory |injuries=Ischemia-reperfusion, Oxidative stress;RONS

...is a key molecular machinery that allows quick metabolic adaptation to ER stress. |keywords=CP: Metabolism, CP: Molecular biology, ER, ER stress, ERO1, MAMs, MERCs, PERK, Bioenergetics, Endoplasmic reticulum, Mitochondri

...are known to simultaneously initiate different cellular responses against stress by triggering parallel mechanisms, therefore NFκB nuclear accumulation was |mipnetlab=3-Nitropropionic acid, Aging, Nrf2 signaling, Oxidative stress, Tert-Buthylhydroquinone

...ena SMSC, Acco A (2018) Effects of silymarin on angiogenesis and oxidative stress in streptozotocininduced diabetes in mice. Biomed Pharmacother 108:232-43. ...is or glycemia. In conclusion, treatment with silymarin red uced oxidative stress and inflammation that were induced in the model of streptozotocin-induced d

...inylglycine) are added to organ preservation solutions to reduce oxidative stress.^1,2 GSH is unstable, however, in University of Wisconsin (UW) so |injuries=Ischemia-reperfusion, Oxidative stress;RONS

...withstand anoxia-induced stress associated with cross-tolerance to thermal stress? ...estuarine habitats potentially exposing them to severe temperature-induced stress during summer low tides. We measured the effect of each temperature on: i)

...R, Sandlers Y, Willard B, Hoppel CL, Nagy LE, Dasarathy S (2019) Oxidative stress mediates ethanol-induced skeletal muscle mitochondrial dysfunction and dysr ...ons (including reduced oxygen consumption, generation of ROS and oxidative stress), increased TCA cycle intermediates, and reversed impaired protein synthesi

...e used a superoxide dismutase knockout mouse to demonstrate that oxidative stress directly impairs investment in morphological (preputial glands) and molecul

...ice: Relevance of cortico-cerebral mitochondrial dysfunction and oxidative stress. Neuroscience 197:99-106. ...ive impairment, and cortico-cerebral mitochondrial dysfunctional/oxidative stress. Because of the involvement of such alterations in AD patients, our data re

...ud-Billoud M, Genaro-Mattos TC, Campos ÉG (2015) Preparation for oxidative stress under hypoxia and metabolic depression: Revisiting the proposal two decades ...narios of biological and physiological cellular responses to environmental stress.

...human diaphragms after MV, and the role of mitochondria-derived oxidative stress in the development of VIDD. ...ene and protein expression. In addition, diaphragmatic force and oxidative stress after exposure to MV for 6 hours were evaluated in mice under different con

|topics=Aging, GPCRs, Oxidative and inflammatory stress, sodium transporters

...shchak VI (2015) Restriction of glucose and fructose causes mild oxidative stress independently of mitochondrial activity and reactive oxygen species in ''Dr ...mitochondrial activity, mitochondrial density, mtROS production, oxidative stress markers and antioxidant defense in fruit flies fed 0.25%, 4% and 10% glucos

...some activity contributes to pro-survival response upon mild mitochondrial stress in ''Caenorhabditis elegans''. PLoS Biol 19:3001302. ...PRmt]) that is mediated by activating transcription factor associated with stress 1 (ATFS-1). The UPRmt increases mitochondrial protein quality control. Mito

...important in cell signalling, oxidative defence mechanisms and [[oxidative stress]].

...prevention or reduction of necrotic glial cell death during the oxidative stress conditions met in neurodegenerative diseases. However, further elucidation ...l death, Glial cell, Neuroprotection, Oxidative phosphorylation, Oxidative stress

...ical PKU mouse identifies cerebral energy pathway disruption and oxidative stress. https://doi.org/10.1016/j.ymgme.2022.03.004 ...n and serotonin representation), energy dysregulation and tissue oxidative stress expand mechanisms underlying neuropathology.

|?Stress |?Stress

...ne expression, respiratory supercomplex, hypoxia, redox sensing, oxidative stress

...rreto Rubem FS</u> (2022) Mitochondrial plasticity in trypanosomatids as a stress adaptation mechanism. Bioblast 2022: BEC Inaugural Conference. In: https:// ...bioenergetics, mitochondrion has a decisive contribution to the oxidative stress, due to the electron leakage from the electron transfer system (ETS). The p

|topics=oxidative stress, hemochromatosis

...H (2014) Role of metabolic H2O2 generation: redox signaling and oxidative stress. J Biol Chem 289:8735-41. ...ged from recent research as a central hub in redox signaling and oxidative stress. Upon generation by major sources, the NADPH oxidases or Complex III of the

...of a high-fat diet, however the actual triggering of endoplasmic reticulum stress was only detected three days later, when IRE-1α was increased. Mitofusin-2 |keywords=Cytokines, Endoplasmic reticulum stress, Hypothalamus, Metabolism, Neurons

...tochondrial function are likely to be more profound, because environmental stress during early life can permanently alter cellular physiology and morphology. |injuries=Oxidative stress;RONS, Hypoxia

...uncoupling. The present study investigates the role of UCP-2 and oxidative stress in mitochondrial oxygen consumption and kidney function in db/db mice as a ...of diabetic nephropathy and the benefits of preventing increased oxidative stress.

:::::'''Keywords:''' mitochondria, oxidative stress, cardiovascular diseases, metabolism

...ing physical exercise in humans [1] and contribute to attenuated oxidative stress in animal models of disease [2]. Nitrate accumulates in saliva and is bioac ...of dietary nitrate on basal metabolic rate (BMR) and markers of oxidative stress in man using a double-blind, randomized cross over design. 15 young healthy

...low-oxygen levels, whereas further pronounced depression induces energetic stress under hypoxia.

...mitochondrial dysfunction mediated by neuroinflammation through oxidative stress. Int J Mol Sci 24:950. https://doi.org/10.3390/ijms24020950 ...t ''P. gingivalis''-LPS causes mitochondrial dysfunction through oxidative stress and inflammatory events in neurodegenerative diseases.

...of cholestatic rats, increasing oxidative capacity and reducing oxidative stress, which, in turn, contribute to liver function recover. |injuries=Oxidative stress;RONS

...g of metabolism modulated by ER–mitochondria communication during early ER stress. ...y mechanism in the modulation of mitochondrial metabolism. During early ER stress, this communication increases as an adaptive mechanism [1]. The signalling

...acylglyceride effects on longevity, mitochondrial metabolism and oxidative stress: insights from Drosophila melanogaster. Mar Drugs 16:E453. ...ides (MAG, both EPA and DHA) on the mitochondrial metabolism and oxidative stress of a short-lifespan model, ''Drosophila melanogaster'', sampled at five dif

...-derived extracellular vesicles protect hippocampal neurons from oxidative stress and synapse damage induced by amyloid-β oligomers. J Biol Chem 293:1957-75 ...rived extracellular vesicles protect neurons against AβO-induced oxidative stress and synapse damage, revealed by loss of pre- and postsynaptic markers. Prot

...Larsson O, Topisirovic I, Trifunovic A (2021) Adaptation to mitochondrial stress requires CHOP-directed tuning of ISR. Sci Adv 7:0971. ...interplay between three transcription factors regulating the mitochondrial stress response: CHOP, C/EBPβ, and ATF4. We show that CHOP acts as a rheostat tha

|title=[[File:HoelF.jpg|left|90px|Hoel Fredrik]] A study on mitochondrial stress responses due to OXPHOS inhibition. ...dria through biogenesis. These processes are crucial for adaptation during stress conditions, and have also been linked to diseases such as Parkinson’s dis

...mitochondria were transferred to the injured hMSCs via TNTs, the oxidative stress was decreased, and the mitochondrial membrane potential of the H<sub>2</sub |injuries=Ischemia-reperfusion, Oxidative stress;RONS

...on alleviates lipid metabolism derangements and protects against oxidative stress in non-obese hereditary hypertriglyceridemic rats. Appl Physiol Nutr Metab ...ted disorders, particularly fatty acid oxidation, steatosis, and oxidative stress in the liver, could be attenuated by carnitine supplementation. The effect

...ase and insulin resistance are associated with increased cardiac oxidative stress in mice. Eur Heart J 34:P5045. ...e investigated how NAFL and insulin resistance relate to cardiac oxidative stress and mitochondrial oxidative capacity in mice.

...G, Hengster P, Margreiter R, Gnaiger E (1999) Does H2O2-mediated oxidative stress reproduce mitochondrial cold preservation/reoxygenation injury in endotheli |injuries=Ischemia-reperfusion, Oxidative stress;RONS

...WJ, Tronstad KJ (2012) Mitochondrial morphology and biogenesis in cellular stress. Mitochondr Physiol Network 17.12. ...uding mitochondrial respiration, may represent an important determinant of stress tolerance. Using new tools to study these phenomena is therefore important

...iate metabolism in the diatom ''Phaeodactylum tricornutum'' under nitrogen stress. Proc Natl Acad Sci U S A 112:412-7. ...d reductants is used to synthesize lipids. To further examine how nitrogen stress triggers the remodeling process, we knocked down the gene encoding for nitr

...le NAD+-dependent enzymes are involved in synaptic plasticity and neuronal stress resistance. Here, we review emerging findings that reveal key roles for NAD

...hoblastic leukemic cell lines ''in vitro'' through assessment of oxidative stress, DNA-fragmentation, mitochondrial function and apoptosis induction. The stu ...le cell gel electrophoresis (comet assay), protein expression of oxidative stress markers, induction of nitric oxide Synthases and expression of pro- and ant

...n periodontal tissues but not in the blood, suggesting a role of oxidative stress on periodontal tissues. Thus, our functional and genetic analysis provided |injuries=Oxidative stress;RONS

...ase in protein abundance of catalase. In this study, a novel mitochondrial stress response was highlighted where accumulation of citrate acted to preserve th |injuries=Oxidative stress;RONS

...nsitivity. OPA1-elicited mitochondrial dysfunction activates an integrated stress response that locally induces muscle atrophy, but via secretion of FGF21 ac |keywords=ER stress, FGF21, OPA1, Mitochondrial dysfunction, Skeletal muscle

|topics=psychopathological stress

|topics=Cell respiration, hypoxia, oxidative stress, Ischemia-reperfusion injury, mitochondrial pathways, respiratory control

...ation of astrocyte redox balance in FXS, which may contribute to oxidative stress. Astrocyte function and mitochondrial bioenergetics are significantly influ |injuries=Oxidative stress;RONS, Hypoxia

...protection mechanism and could be involved in protecting against oxidative stress.

...n of endogenous antioxidants with Auranofin causes mitochondrial oxidative stress which can be countered by selenium supplementation. Biochem Pharmacol 146:4 ...reductase (TrxR) and glutathione peroxidase (GPx), resulting in oxidative stress and the initiation of a pro-apoptotic cascade. The effect of Auranofin expo

...ry capacity, have a more fragile heart and will be more prone to oxidative stress and HF, and less tolerant to temperature changes and other stressors. Our r

...ultramarathon running on mitochondrial function of platelets and oxidative stress parameters: a pilot study. https://doi.org/10.3389/fphys.2021.632664 ...ential post-race as a protective consequence of the race-related oxidative stress and potential threat to the kidney. Our findings point toward an interrelat

...in the center of cellular metabolism, play a pivotal role in adaptation to stress conditions. We found that mitochondrial dysfunction and adaptation processe

...chondrial metabolism through regulation of cellular responses to oxidative stress. A low level of p66Shc protein or its complete ablation protects against nu ...oxidative stress. The status of the antioxidant defense system, oxidative stress markers and the p66Shc-Ser36 phosphorylation pathway were measured in these

...er A, Kuznetsov AV, Margreiter R, Gnaiger E (2002) H2O2-mediated oxidative stress versus cold ischemia-reperfusion: mitochondrial respiratory defects in cult |abstract=Oxidative stress to vascular endothelium plays an important role in cold ischemia-reperfusio

...ot fish hearts? Understanding the role of mitochondrial function with heat stress in ''Notolabrus celidotus''. PLoS One 8:e64120. ...HF in heat stressed hearts in fish and play a significant role in thermal stress tolerance, and perhaps limit species distributions by contributing to HF.

...blocking the typical cancer progression. The main aim of this review is to stress some neglected aspects of oxidative mitochondrial metabolism of cancer cell ...ic Biomarkers, Metabolism, Mitochondria, Molecular therapeutics, Oxidative stress, ROS

|abstract=Mitochondrial dysfunction and oxidative stress participate in the development of diabetic complications, however, the mech ...ds=Diabetes mellitus, Mitochondria, Alpha-tocopherol,Coenzyme Q, Oxidative stress

...one system activation, cardiac autonomic neuropathy, endoplasmic reticulum stress, microvascular dysfunction, and a myriad of cardiac metabolic abnormalities |injuries=Oxidative stress;RONS, Mitochondrial disease

...brane potential, Psim), whereas intact cardiac cells can display oxidative stress either when mitochondria become more uncoupled (i.e., low Psim) or when mit

...ion respirometry, ROS production and footprints of oxidative and nitrative stress processes in intact human sperm cells. We showed that mitochondrial dysfunc |keywords=Mitochondria, Reactive oxygen species, Nitro-oxidative stress, Sperm motility and transport, Male infertility

...recent data, besides confirming the mitochondrial role in tissue oxidative stress and protection, show interplay between mitochondria and other ROS cellular

|topics=Cell respiration, hypoxia, oxidative stress, Ischemia-reperfusion injury, mitochondrial pathways, respiratory control

...LC, Antunes LMG, Barbosa F Jr (2019) Cytotoxicity, mutagenicity, oxidative stress and mitochondrial impairment in human hepatoma (HepG2) cells exposed to cop ...ed assays), mutagenicity (cytokinesis-block micronucleus assay), oxidative stress (total reactive oxygen species and superoxide anion production) and mitocho

...lts point to the potential of this strategy for the treatment of oxidative stress-based cardiac diseases. |injuries=Oxidative stress;RONS, Hypoxia

...patients, due mostly to mitochondrial dysfunction and resulting oxidative stress. Endurance exercise has been firmly established as a way to reduce diabetes ...rdiovascular disease, Vascular disease, Reactive oxygen species, Oxidative stress, Mitochondria, Mitochondrial dysfunction, Oxidative phosphorylation, Exerci

...itochondrial NADPH plays an important role in the protection against redox stress and cell death and mitochondrial NADPH-utilizing thioredoxin reductase 2 le

...ized by reduced nitric oxide bioavailability as a consequence of oxidative stress. Damaged and dysfunctional mitochondria as a result of CKD are likely a lar ...Improving mitochondria health and reducing mitochondria derived oxidative stress may be a potential therapeutic target for improving endothelial function in

...ion, our findings show that SIL A protects against SNP-induced nitrosative stress at the level of mitochondria making it potentially beneficial against neuro

...PM, Mottis A, Auwerx J (2016) Mitonuclear communication in homeostasis and stress. Nat Rev Mol Cell Biol 17:213-26.

...pa GB, Guzy RD, Vanden Hoek TL, Schumacker PT (2011) Mitochondrial oxidant stress triggers cell death in simulated ischemia-reperfusion. Biochim Biophys Acta ...of Mn-SOD or mito-PHGPx. These findings suggest that mitochondrial oxidant stress causes oscillation of the mPTP prior to reperfusion. Cytochrome c release f

...ter 24 h. In rotenone-inhibited HepG2 cells (i.e., already under oxidative stress) MitoQ₁₀ sharply decreased rotenone-induced ''J''_m, b |injuries=Oxidative stress;RONS

...of LD may be toxic for photoreceptors cells of the retina under oxidative stress. Collectively, these findings indicate that FATP-mediated LD formation in R

...are ER, Vercesi AE, Passarelli M (2012) Inhibition of macrophage oxidative stress prevents the reduction of ABCA-1 transporter induced by advanced glycated a ...generation was not able to restore ABCA-1 levels. Inhibition of oxidative stress induced by AGE-albumin prevents disturbances in reverse cholesterol transpo

...ter lipid storing and oxidative capacity, resulting in increased oxidative stress, which in turn could deteriorate hepatic mitochondrial function in chronic

...g YJ, Prolla TA, Santana LF, Rabinovitch PS (2011) Mitochondrial oxidative stress mediates angiotensin II-induced cardiac hypertrophy and Galphaq overexpress ...ral cardiovascular diseases; however, the roles of mitochondrial oxidative stress and DNA damage in hypertensive cardiomyopathy are not well understood.

...-activated mitochondrial phospholipase iPLA2γ prevents lipotoxic oxidative stress in synergy with UCP2, amplifies signaling via G-protein-coupled receptor GP ...ic lipotoxicity evolves from acute free fatty acid (FA)-mediated oxidative stress, unprotected by antioxidant mechanisms. Since mitochondrial uncoupling prot

...blood mononuclear cells and platelets mitochondrial dysfunction, oxidative stress, and circulating mtDNA in cardiovascular diseases. J Clin Med 9 pii:E311. ...ible adjunct of PBMCs' and platelets' mitochondrial dysfunction, oxidative stress, and circulating mtDNA as biomarkers of CVD diagnosis and prognosis. This n

...echa B, Cutrin JC, Boveris A (1993) Time course and mechanism of oxidative stress and tissue damage in rat liver subjected to in vivo ischemia-reperfusion. J

...down the functions controlled by Nrf2 in muscle mitohormesis and oxidative stress defense during mitochondrial OXPHOS inefficiency.

...re often depleted through mitochondrial dysfunction and elevated oxidative stress. ...Alzheimer’s disease, Ascorbate, Energy production, Mitochondria, Oxidative stress

...otects maize seedlings against mitochondrial damage due to low temperature stress. In ...ios, respiration rates, or respiration rate ratios. In the low temperature stress study, there was a hybrid by treatment interaction. Stamina did not effect

|?Stress |?Stress

...ribed. These include oxidative stress, inflammation, endoplasmic reticulum stress, aberrant insulin signaling, accumulation of advanced glycated end-products |injuries=Cell death, Oxidative stress;RONS

|topics=Oxidative stress, tumors, hemorrhage, brain

...ograms cardiac substrate metabolism via protein O-GlcNAcylation to enhance stress adaptation. JCI Insight 2:96184. ...ams cardiac substrate metabolism to favorably modify adaptation to chronic stress. Our results also suggest that increased fatty acid oxidation in the chroni

...Toxicology and also Immunology. My research is mainly focused on oxidative stress, tryptophan metabolism, nanoparticles, neurodegenerative disorders, immunot

...n impairs ADP-stimulated respiration and increases mitochondrial oxidative stress in primary human skeletal myotubes. Free Radic Biol Med 52:198-207. ...ulated maximal mitochondrial respiratory capacity, mitochondrial oxidative stress, and apoptosis in primary human skeletal myotubes, suggesting that mitochon

...sed mice. These pathological changes from a possible maladaptive oxidative stress response provide insight into declines in muscle functioning caused by expo |keywords=Metabolism, Mitochondria, Resistance to stress, Free radicals

...-dependent dual role of mitochondrial ROS in redox signaling and oxidative stress. |injuries=Ischemia-reperfusion, Oxidative stress;RONS

...Brusco A, Seneca S, Lombès A, Taylor RW, Battersby BJ (2019) Mitochondrial stress response triggered by defects in protein synthesis quality control. Life Sc ...itochondrial protein synthesis with chloramphenicol completely blocks this stress response. Together, our data establish a mechanism linking major cell biolo

...gen utilization in salt-induced hypertension and renal medullary oxidative stress. ..., oxygen utilization, salt-induced hypertension, renal medullary oxidative stress

...m the diet reverses inflammation, mitochondrial dysfunction, and oxidative stress in hippocampus. Antioxidants (Basel) 10:487. ...rt-term fructose-rich diet induced mitochondrial dysfunction and oxidative stress, associated with an increased concentration of inflammatory markers and dec

|abstract=Mitochondrial dysfunction and oxidative stress are among the earliest and most frequently reported pathogenic changes in l ...sation for mitochondrial genetics, bioenergetic dysfunction, and oxidative stress in the pathogenesis of age-related disease.

...It has been proposed that derangements in cardiac metabolism and oxidative stress may underlie the progression of this comorbidity, but scarce evidence exist ...sed substrates, depleted glutathione, and evidence of persistent oxidative stress in their atrial tissue.

...on efficiency, and block the massive loss of skin nutrients and net energy stress. Furthermore, LQ can promote collagen synthesis and keratinocyte proliferat |injuries=Oxidative stress;RONS

...st whether estradiol directly affects mitochondria by preventing oxidative stress and protecting frail mitochondria. Incubation with estradiol at normal intr |keywords=Estrogenic compound, Oxidative stress, Genistein, Cytochrome c, Mitochondria, Antioxidant

...sembly mutants display unexpected changes in markers of cellular oxidative stress at stationary phase. Our results suggest that mitochondria may not be a maj |keywords=Cytochrome c oxidase (complex IV) assembly, Mitochondria, Oxidative stress, Stationary phase, Yeast

...e-based technologies for the study of mitochondrial dysfunction, oxidative stress and fibrogenesis in NAFLD. We highlight the limitations of current methodol |keywords=Citric acid cycle, Fatty acid oxidation, Fibrosis, NAFLD, Oxidative stress, Stable isotopes

...alters gene expression, mitochondrial content, inflammation and oxidative stress without affecting high-fat diet-induced obesity or insulin resistance. Bioc ...ial content and function and elevated inflammatory signaling and oxidative stress.

...The impaired mitochondrial function can contribute to increased oxidative stress by triggering the reverse electron transport from the CoQ₁₀ cycl |keywords=Mitochondrial bioenergetics, Oxidative stress, Platelets, Reprogramming, Urothelial carcinoma

...tabolic processes of ''S. culicis'' are modulated in response to oxidative stress conditions, providing new perspectives on the biology of the trypanosomatid ...=Antioxidant system, Ascorbate peroxidase, Energetic metabolism, Oxidative stress, Pentose phosphate pathway

|title=Targeting mitochondrial redox stress reveals two phases for reversal of mitochondrial dysfunction in aged mouse ...hondrial membrane, to test the interaction between mitochondrial oxidative stress, energetics, and muscle performance in aged mice.

...d for the effective protection of liver cells from mitochondrial oxidative stress induced by TNFα. These findings emphasize the importance of maintaining th ...atocytes, Liver injury, Mitochondrial dysfunction, Mitochondrial oxidative stress, Mitochondrial respiration, Tricarboxylic acid cycle

...covered. Involvement of this protein in cell death is related to oxidative stress. Phosphorylation of p66Shc at Ser36 can be activated by extracellular or in |injuries=Oxidative stress;RONS

...tments to restore cellular homeostasis are crucial to survive this type of stress. In this study, we exposed male ''Drosophila melanogaster'' to two modulate ..., Fasting, High‐fat diet, Metabolic flexibility, Mitochondrial metabolism, Stress response

|keyword=hypoxia, ischaemic heart disease, nitric oxide, oxidative stress, uncoupling proteins (UCPs)

...NAD and NADP profoundly affect aging-influencing factors such as oxidative stress and mitochondrial activities, and NAD-dependent sirtuins also mediate the a

...myocyte function by increasing antioxidant capacity and reducing oxidative stress in cryopreserved rat hearts during a prolonged preservation time, resulting ...itochondrial inhibitor, Myocardial ischaemia-reperfusion injury, Oxidative stress

...op growth of tumors that shifted to mitochondrial FAO to survive oxidative stress and nutrient scarcity.

...ssion to mitochondrial O₂ consumption, and markers of oxidative stress were not altered following bed rest. Altogether, while bed rest impairs mit |injuries=Oxidative stress;RONS

...or for the regeneration process in the necrotic liver damaged by oxidative stress. |injuries=Oxidative stress;RONS

...tory dysfunctions of PBMCs link with the cellular inflammation / oxidative stress and cardiac disturbance in early-stage HF. |injuries=Oxidative stress;RONS

...in neurodegenerative disease as neurons are highly sensitive to oxidative stress and mitochondrial impairment. ...3-monooxygenase, Kynurenine pathway, Mitochondrial dysfunction, Oxidative stress

...uroprotective effect of the novel compound ITH33/IQM9.21 against oxidative stress and Na⁺ and Ca²⁺ overload in motor neuron-like NSC-34 ...bindin-D28k levels. Therefore, ITH33 was neuroprotective against oxidative stress and Na⁺/Ca²⁺ overload, both of which are involved in

...CA (2021) Differential age-dependent mitochondrial dysfunction, oxidative stress, and apoptosis induced by neonatal hypoxia-ischemia in the immature rat bra ...n, reduced TCA cycle enzymes, and RC activities and induction of oxidative stress in this group of animals. Considering that HIP3 and the sham animals showed

...oncentration in cephalopod blood is modulated in response to physiological stress and that octopine metabolism is closely integrated with the metabolism of g

|?Stress |?Stress

|abstract=Oral inflammatory pathologies are linked to increased oxidative stress, thereby partly explaining their relevance in the etiology of systemic diso ...TP generation. These findings provide insight into the nature of oxidative stress in oral inflammatory pathologies.

|keyword=mitigation of metabolic stress in clinical conditions: obesity, diabetes, sarcopenia and alcohol abuse

...ies (ROS) in the reproductive system. In: Agarwal A, et al (eds) Oxidative stress in human reproduction. Springer, Cham. https://doi.org/10.1007/978-3-319-48 ...high concentration, overwhelming the antioxidant defense system, oxidative stress results, and this may lead to cellular dysfunction via lipid peroxidation,

...Mitochondria are affected by TAA secondarily as a consequence of oxidative stress. Oxidation of the NADH-dependent substrates of respiratory Complex I is sig |injuries=Oxidative stress;RONS

...ounds rescue neurons from Abeta-induced cell death by preventing oxidative stress, which in turn inhibits the activation of p38, protecting neurons from cell

...own of bioenergetics: Protection of macromolecules and survivorship during stress. '''Bioblast 2022: BEC Inaugural Conference.''' In: https://doi.org/10.2612 ...ls can be extended to a desiccation-sensitive, whole organism during water stress.

|abstract=We have investigated the differential mitochondrial oxidative stress between males and females to understand the molecular mechanisms enabling f |injuries=Oxidative stress;RONS

...ial pathways associated with distinct adolescent behavioral phenotypes and stress response. https://doi.org/10.1038/s41398-023-02648-3 ...le also underscoring the detrimental functional consequences of adolescent stress on the PFC.

...contribute to explain both the ability of aluminium to generate oxidative stress and its suggested potential to act as an etiological factor by promoting th |keywords=Aluminium, High-resolution respirometry, Mitochondria, Oxidative stress, Parkinson’s disease, Rat brain

...y to fully understand the contribution of mitochondrial mediated oxidative stress to pathology of PE.

Mitochondria are under stress from external factors as well as from their own respiratory activity. Maint ...harbouring mutations in MQC pathways to address the role of mitochondrial stress signaling and mitochondria homeostasis in PD.

...Surprisingly,this cellular respiration alteration persists even after the stress factor is removed. We suggested that this irreversible decrease in renal ox |injuries=Cell death, Ischemia-reperfusion, Oxidative stress;RONS

...ng mitochondrial dysfunction, steatosis, acute inflammation, and oxidative stress.

...sed respiration unless glucose is present; and (c) mitochondrial oxidative stress must precede the insulin stimulus to cause insulin resistance, explaining w ...s=Adipocyte, Glucose, Insulin, Insulin resistance, Mitochondria, Oxidative stress, Respiration

...h a complex III-dependent mechanism. Therefore, a combination of oxidative stress and respiration disturbance could partly explain aerobic PYO toxicity. Surp |keywords=Saccharomyces cerevisiae , Aerobiosis, Anaerobiosis, Oxidative stress, Phenazine, Pyocyanin, Yeast mutants

...ions]] [[Instrument and method::Oxygraph-2k]] [[Diseases::Inherited]] OR [[Stress::Mitochondrial disease]] ...acts]] [[Instrument and method::Oxygraph-2k]] [[Diseases::Inherited]] OR [[Stress::Mitochondrial disease]]

|injuries=Ischemia-reperfusion, Oxidative stress;RONS

the pathological stress of cardiac volume overload which is stress.

...ransfer pathway, stem cells, iPSC, mitochondrial disease, mtDNA, oxidative stress, metabolic reprogramming

...t result in increased oxidative stress. Normal levels of ROS and oxidative stress could also be a result of an active compensatory mechanism such as a mild i |injuries=Oxidative stress;RONS

...lipids for energy, contributes to these diseases. The effects of oxidative stress are mitigated by an endogenous antioxidant enzyme network, but little is kn |injuries=Oxidative stress;RONS

...vely correlated with urinary 8-hydroxydeoxyguanosine, a systemic oxidative stress marker, in CHF patients. Importantly, mitochondrial ROS generation in PBMCs |injuries=Oxidative stress;RONS

...ess impact and management can partly explain tolerance to high temperature stress in fish. ...tween heart lipid composition and individual tolerance to an acute thermal stress, pointing out to mitochondria as a likely mechanistic cause of general home

...and 47.4 ± 2.1%, respectively. The proteomics analysis revealed that under stress conditions, microalgae altered cellular components such as the nucleus and

...asive treatment that promotes energy production and reduces both oxidative stress and inflammation, and has garnered increasing attention in recent years. MB

...utraceutical for the prevention of mitochondrial dysfunction and oxidative stress in brain aging and neurodegenerative diseases. ...ration, Cardiolipin, Mitochondrial dynamics, Nitrosative stress, Oxidative stress, Rice bran extract

...a leading role in opposing the high ASL glucose level as well as oxidative stress in CF.

...as shown that selenium can protect trophoblast mitochondria from oxidative stress. This report examines mitochondrial function and content in trophoblasts su

...disturbance of glutamatergic neurotransmission and induction of oxidative stress in vitro in brain of adolescent rats. Neurotox Res 32:276-90. ...idation and GSH levels, making unlikely a secondary induction of oxidative stress through overstimulation of glutamate receptors. In contrast, KAA and AAA di

...le. Furthermore, Mfn2 deficiency was associated with endoplasmic reticulum stress, enhanced hydrogen peroxide concentration, altered reactive oxygen species ...er-specific Mfn2 KO mice, glucose intolerance, hepatic gluconeogenesis, ER stress, hydrogen peroxide, metabolic homeostasis, ROS, JNK, N-acetylcysteine

...nd besides their expected involvement in the cell survival of hyperosmotic stress, they surprisingly both contribute to an efficient survival of hypoosmotic

...increases of extracellular lactate, choline and glycerol, and by oxidative stress, while mitochondrial function remains normal for at least 90 minutes. Membr

...nd RTG2-dependent retrograde signaling controls mitochondrial activity and stress resistance in ''Saccharomyces cerevisiae''. Free Radic Biol Med 81C:30-7. induction of antioxidant defenses and stress resistance.

...endorse this protocol as the method of choice for metabolic and oxidative stress experiments with fresh isolated rat brain mitochondria. ...ain, EDTA, EGTA, Isolation procedure, Mitochondrial respiration, Oxidative stress

...latonin and its metabolites ameliorate UVR-induced mitochondrial oxidative stress in human MNT-1 melanoma cells. Int J Mol Sci 19:E3786. ...ch express melatonin receptors (MT1 and MT2) against UVB-induced oxidative stress and mitochondrial dysfunction, including the uncoupling of oxidative phosph

...sistent metabolic perturbations in a diabetes phenotype. Overall, nutrient stress in GK SMCs caused a persistent decline in eNOS and mitochondrial function a |injuries=Oxidative stress;RONS

...teine 684 (C684) of MFN2. Mitochondrial hyperfusion represents an adaptive stress response that confers transient protection by increasing mitochondrial ATP |keywords=Fusion/fission, Hyperfusion, MFN2, Mitochondria, Oxidative stress

...yeast to mammals. However, the underlying molecular mechanisms regulating stress resistance during aging are still largely unknown. Here we identify Krüppe

...se-regulated protein (GRP78) were up-regulated, both typical markers of ER stress. However, GRP78 was down-regulated at the protein level. A pro-apoptotic sh |keywords=Endoplasmic reticulum stress, Gene expression, Inflammatory response, Mitochondria, Proteome analysis

...anoxia/reoxygenation, and temperature variations known to elicit oxidative stress. Their mitochondrial electron transport system is also connected to an alte |injuries=Oxidative stress;RONS

...Hu M, Tang Z (2018) Neuroprotective effect of phosphocreatine on oxidative stress and mitochondrial dysfunction induced apoptosis ''in vitro'' and ''in vivo' ...n vivo'' rely on normalizing mitochondrial function and reducing oxidative stress via Akt mediated Nrf2/HO-1 pathway, suggesting that PCr may be a novel ther

...d I, Lau GY, Jolly J, Seebacher F (2022) Rates of warming impact oxidative stress in zebrafish (''Danio rerio''). ...erature increase affect mitochondrial bioenergetics and modulate oxidative stress. We exposed zebrafish (''Danio rerio'') to warming from 20°C to 28°C over

...g flies, possibly related to disruption of energetic metabolism, oxidative stress, and deregulation of genes implied in growth, sleep, and metabolism. ...y, Dithiocarbamate, Embryotoxicity, Mitochondrial bioenergetics, Oxidative stress

...r mitochondrial permeability transition pore to calcium load and oxidative stress. Physiol Res 61:S165-72. ...etter protected against damaging effects of the calcium load and oxidative stress. We can only speculate that the lower sensitivity to calcium-induced swelli

...uchi T, Rabinowitz J, Maack C, Dudek J (2023) Activation of the integrated stress response rewires cardiac metabolism in Barth syndrome. https://doi.org/10.1 ...yses revealed that the activation of the eIF2α/ATF4 axis of the integrated stress response upregulates one-carbon metabolism, which diverts glycolytic interm

...cadalenes derivates towards breast cancer cells: involvement of oxidative stress-mediated apoptosis. https://doi.org/10.7717/peerj.15586 ...ene suggested that this natural product exerted cytotoxicity via oxidative stress as evidenced in a significantly increase of intracellular ROS levels and in

...idative phosphorylation, potentially impacting the management of oxidative stress. Longitudinal studies using the framework of metabolic control analysis hav

...-NADPH oxidase levels were high in control aged rats, suggesting oxidative stress burden in these rats. GP treatment in aged rats restored these parameters t |keywords=Oxidative stress, Grape powder, Blood pressure, Kidney functions

...response to muscle disuse, challenge the necessity for increased oxidative stress during inactivity, and establish that ω-3 supplementation preserves oxidat |keywords=Metabolism, Mitochondrial function, Oxidative stress, Buffer Z, Blebbistatin, Amplex Red in muscle fibers

...ardiomyopathy in mice is associated with lipotoxicity-associated oxidative stress, fibrosis, and disturbed calcium homeostasis, rather than impaired cardiac

|?Stress

...ading to apoptosis and necrosis. Hypoxic or anoxic stress does not signal stress in turtle brain but rather protective mechanisms with the onset of anoxia. |injuries=Ischemia-reperfusion, Oxidative stress;RONS

|?Stress |?Stress

...p-38 mitogen-activated protein kinase, nuclear factor kappa B (NF-κB), and stress-activated protein kinases/Jun amino-terminal kinases (SAPK/JNK) in C2C12 my

...s, lack of vigor, inability to accumulate fat, reduced ability to tolerate stress, and premature death. Other prominent pathological changes included low spe |injuries=Oxidative stress;RONS

...ion, AMPK upregulates genes involved in oxidative metabolism and oxidative stress resistance by regulating a number of transcription factors which affects th

...reactive oxygen species production in mouse models of aging and oxidative stress but not denervation. https://doi.org/10.1002/rco2.29 ...ic nerve transection (denervation), and in response to increased oxidative stress (Sod1^-/- mice). Further, we asked whether the mitochondrial-targ

...b>2</sub>O₂ production, higher resistance toward both oxidative stress, and severe hypoxia compared with control cells. These results suggest an i |injuries=Oxidative stress;RONS, Hypoxia

...-term (transcriptional/translational) homeostatic mechanisms of stress and stress responses. The redox set point is a variable moving target value, modulated

...ed by β-cell mitochondria as a result of metabolic stress activate several stress-response pathways. This paper focuses on mechanisms whereby ROS affect mito

...raction between dysregulation of respiratory protein expression, oxidative stress, and mitochondrial function with age. |injuries=Oxidative stress;RONS

...tivity and ETS coupling efficiency under conditions of amplified oxidative stress could reinforce mitochondrial integrity and improve redox status, beneficia

...y and atherogenesis under conditions of hypercholesterolemia and oxidative stress. |keywords=Oxidized lipoproteins, Oxidative stress, Oxygen consumption, Enzymes of the mitochondrial respiratory chain

...Cadenas S, Melov S (2009) Increase in mitochondrial biogenesis, oxidative stress, and glycolysis in murine lymphomas. Free Radic Biol Med 46:387-96. |injuries=Oxidative stress;RONS

...g the tissue to adapt to developmental changes and respond to preeclampsia stress, whereas the inability to reprogram placental metabolism may result in seve

...cle mitochondrial function: Increasing metabolic power increases oxidative stress. Comp Biochem Physiol A Mol Integr Physiol 230:115-21. ...ee radical production. To examine how metabolic requirements and oxidative stress vary between species, we explored the variation in flight mechanics and met

...-1 and HFGD groups at 24 h after acetaminophen application. Mild oxidative stress induced by acetaminophen was confirmed by measurement of malondialdehyde. L |keywords=Acetaminophen, Cytokines, Fatty liver, Hepatotoxicity, Oxidative stress

...on and progression of kidney ischemia/reperfusion injury linking oxidative stress, inflammation, and cell death. The dependence of kidney proximal tubule cel

...elial cells, we have recently shown the sequential intervention of various stress proteins which are crucial to prevent apoptosis and maintain cell function.

...ose metabolism, and lipid metabolism. In: Huang C, Zhang Y (eds) Oxidative stress. Springer, Singapore. https://doi.org/10.1007/978-981-16-0522-2_9 ...glucose metabolism increases the production of ROS and enhances oxidative stress by glucose auto-oxidation and glycosylation of proteins and activated the p

...irus. Resolution is normally achieved after viral clearance as the initial stress activates a hormetic negative feedback mechanism. It is therefore possible |injuries=Oxidative stress;RONS

...Together, it suggests that Var1 physically interacts with mtDNA and under stress negatively regulates its maintenance [1].

...ism is suppressed during torpor and how this suppression affects oxidative stress. In liver and skeletal muscle, state 3 respiration measured at 37 °C with ...roxide, Top-down elasticity analysis, Oxidative phosphorylation, Oxidative stress

...h hydrogen peroxide, indicating a higher capability to cope with oxidative stress. |injuries=Oxidative stress;RONS

|?Stress |?Stress

...2B-Fc provided beneficial effects on cardiac function in prolonged cardiac stress in cardiotoxicity model. By blocking myostatin, ACVR2B-Fc potentially reduc

...ophy during cancer cachexia and is linked to muscle-specific mitochondrial stress. https://doi.org/10.1172/jci.insight.155147 ...tochondrial alterations that could involve adaptive responses to metabolic stress. Eventual muscle-specific restorations in force and bioenergetics highlight

...alis'' Kaczmarek, Mioduchowska, Poprawa & Roszkowska, 2020 to heat related stress. |keywords=water bears, Tardigrada, Eutardigrada, heat stress, mitochondria

|abstract=Mitochondrial dysfunction and bioenergetic stress play an important role in the etiology of alcoholic liver disease. Previous ...f key mitochondrial bioenergetic parameters and the attenuation of hypoxic stress.

|injuries=Oxidative stress;RONS

...aur T, Stöggl W, Kranner I (2022) Retrograde signalling during high light stress involves reactive carbonyl / electrophile species. '''Bioblast 2022: BEC In ...ific role of (¹O₂ in RES signalling under high light stress. Finally, a comparison to differential gene expression in response to H<sub

...sing its capacity for fatty acid oxidation. Along with increased oxidative stress, this may represent one of the earliest signs of dysfunction that will ulti ...tty acid metabolism, Fructose, Insulin resistance, Mitochondria, Oxidative stress, Sirtuins, Type‐2 diabetes mellitus

respiration, and redox status. Oxidative stress was evaluated by measurements of mitochondrial hydrogen peroxide, carbonyl ...ting that administration of CORM-3 during sepsis elicited a mild oxidative stress response that stimulated mitochondrial biogenesis with [[PGC-1alpha|(PGC)-1

...orescin as an indicator of reactive oxygen species formation and oxidative stress. Chem Res Toxicol 5:227-31. ...However, DCFH remains an attractive probe as an overall index of oxidative stress in toxicological phenomena.

...ular respiration, but the level of peripheral muscle fatigue and metabolic stress could be explaining factors.

...-Flecha B, Peralta J, Carreras MC, Poderoso JJ, Boveris A (1994) Oxidative stress in muscle and liver of rats with septic syndrome. Free Radic Biol Med 16:44

...under tissue conditions in vivo. Hyperoxic conditions may impose oxidative stress and may increase maximum aerobic performance.

|keyword=Neuropathology, Oxidative stress

...2',7'-dichlorodihydrofluorescein diacetate staining. PD-related oxidative stress was simulated by paraquat and rotenone, and mitochondrial membrane potentia ...tochondrial function and protect mitochondria from PD-associated oxidative stress by activating the mitochondrial unfolded protein response (UPR^mt

...glycol dimethacrylate impairs bioenergetic functions and induces oxidative stress in mitochondria via inhibiting respiratory Complex I. Dent Mater 34:e166-e1 ...that dental resin monomers lower cellular viability and provoke oxidative stress. Reactive oxygen species (ROS) formation has a key role in triethylene glyc

...us exercise regimens on platelet mitochondrial bioenergetics under hypoxic stress. ...e phosphorylation and thrombin generation (TG) of platelets during hypoxic stress. Twenty-four sedentary males were randomized to perform either aerobic inte

...a rare cause of familial PD. Although a critical role of DJ-1 in oxidative stress response and mitochondrial function has been recognized, the effects on mit |keywords=Parkinson's disease (PD), Oxidative stress response, Mitochondria, Lysosomes, DJ-1, ROS, Mouse embryonic fibroblasts (

...ON, Sciutto E, Fragoso G, Pedraza-Chaverri J (2022) GK-1 Induces oxidative stress, mitochondrial dysfunction, decreased membrane potential, and impaired auto ...</sub>) production, GSSG, and protein carbonyl content, inducing oxidative stress (OS) in tumoral tissues. This imbalance between reactive oxygen species (RO

...sion and promote longevity. In this way, HIF-1 appears to link respiratory stress in the mitochondria to a nuclear transcriptional response that promotes lon |injuries=Ischemia-reperfusion, Oxidative stress;RONS