Difference between revisions of "Dyscoupled respiration"
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|abbr=n.a. | |abbr=n.a. | ||
|description='''Dyscoupled respiration''' is distinguished from intrinsically (physiologically) | |description='''Dyscoupled respiration''' is [[LEAK respiration]] distinguished from intrinsically (physiologically) uncoupled and from extrinsic experimentally [[Uncoupler|uncoupled]] respiration as an indication of extrinsic uncoupling (pathological, toxicological, pharmacological by agents that are not specifically applied to induce uncoupling, but are tested for their potential dyscoupling effect). Dyscoupling indicates a mitochondrial dysfunction. Β | ||
In addition to intrinsic [[uncoupling]], dyscoupling occurs under pathological and toxicological conditions.Β Thus a distinction is made between physiological uncoupling and pathologically defective dyscoupling in mitochondrial respiration. | In addition to intrinsic [[uncoupling]], dyscoupling occurs under pathological and toxicological conditions.Β Thus a distinction is made between physiological uncoupling and pathologically defective dyscoupling in mitochondrial respiration. |
Revision as of 05:47, 31 October 2012
Description
Dyscoupled respiration is LEAK respiration distinguished from intrinsically (physiologically) uncoupled and from extrinsic experimentally uncoupled respiration as an indication of extrinsic uncoupling (pathological, toxicological, pharmacological by agents that are not specifically applied to induce uncoupling, but are tested for their potential dyscoupling effect). Dyscoupling indicates a mitochondrial dysfunction.
In addition to intrinsic uncoupling, dyscoupling occurs under pathological and toxicological conditions. Thus a distinction is made between physiological uncoupling and pathologically defective dyscoupling in mitochondrial respiration.
Abbreviation: n.a.
Reference: Pesta 2012 Methods Mol Biol
MitoPedia methods:
Respirometry
MitoPedia topics: "Respiratory state" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property.
Respiratory state"Respiratory state" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property.