Jezek P

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Name Jezek Petr, Prof., Dr.
Institution
Petr Jezek

Institute of Physiology, Dept. No. 75

Academy of Sciences of the Czech Rep.

Address Videnska 1083, 14220
City Prague
State/Province
Country Czech Republic
Email jezek@biomed.cas.cz
Weblink
O2k-Network Lab CZ Prague Jezek P


Labels: Field of research: Basic 



Contents

Publications

Published Reference
Rohlenova 2016 Antioxid Redox Signal 2016 Rohlenova K, Sachaphibulkij K, Stursa J, Bezawork-Geleta A, Blecha J, Endaya B, Werner L, Cerny J, Zobalova R, Goodwin J, Spacek T, Alisadeh E, Yan B, Nguyen M, Vondrusova M, Sobol M, Jezek P, Hozak P, Truksa J, Rohlena J, Dong L, Neuzil J (2016) Selective disruption of respiratory supercomplexes as a new strategy to suppress Her2high breast cancer. Antioxid Redox Signal [Epub ahead of print].
Smolkova 2015 Int J Biochem Cell Biol 2015 Smolková K, Dvořák A, Zelenka J, Vítek L, Ježek P (2015) Reductive carboxylation and 2-hydroxyglutarate formation by wild-type IDH2 in breast carcinoma cells. Int J Biochem Cell Biol 65:125-33.
Plecita-Hlavata 2015 J Bioenerg Biomembr 2015 Plecitá-Hlavatá L, Ježek J, Ježek P (2015) Aglycemia keeps mitochondrial oxidative phosphorylation under hypoxic conditions in HepG2 cells. J Bioenerg Biomembr 47(6):467-76.
Jezek 2015 Antioxid Redox Signal 2015 Ježek J, Dlasková A, Zelenka J, Jabůrek M, Ježek P (2015) H2O2-Activated Mitochondrial Phospholipase iPLA2γ Prevents Lipotoxic Oxidative Stress in Synergy with UCP2, Amplifies Signaling via G-protein-coupled receptor GPR40, and regulates insulin secretion in pancreatic β-cells. Antioxid Redox Signal 23:958-72.
Plecita-Hlavata 2015 Am J Respir Cell Mol Biol 2015 Plecitá-Hlavatá L, Tauber J, Li M, Zhang H, Flockton AR, Pullamsetti SS, Chelladurai P, D'alessandro A, El Kasmi KC, Ježek P, Stenmark KR (2015) Constitutive reprogramming of fibroblast mitochondrial metabolism in pulmonary hypertension. Am J Respir Cell Mol Biol 55:47-57.
Jaburek 2013 Int J Biochem Cell Biol 2013 Jabůrek M, Ježek J, Zelenka J, Ježek P (2013) Antioxidant activity by a synergy of redox-sensitive mitochondrial phospholipase A2 and uncoupling protein-2 in lung and spleen. Int J Biochem Cell Biol 45:816-25.
Jezek 2011 AbstractMitoComLectures 2011 Jezek P, Dlaskova A, Santorova J, Spacek T, Smolkova K, Tauber J, Mlodzianoski MJ, Bewersdorf J (2011) 3D visualization of mitochondrial network and mtDNA nucleoids at 30 nm by biplane FPALM microscopy. Abstract MitoCom Lectures.
Jezek 2010 Physiol Res 2010 Ježek J, Jabůrek M, Zelenka J, Ježek P (2010) Mitochondrial phospholipase A2 activated by reactive oxygen species in heart mitochondria induces mild uncoupling. Physiol Res 59:737-47.
Smolkova 2010 J Bioenerg Biomembr 2010 Smolková K, Bellance N, Scandurra F, Génot E, Gnaiger E, Plecitá-Hlavatá L, Ježek P, Rossignol R (2010) Mitochondrial bioenergetic adaptations of breast cancer cells to aglycemia and hypoxia. J Bioenerg Biomembr 42:55-67.
Plecita-Hlavata 2009 Int J Biochem Cell Biol 2009 Plecita-Hlavata L, Jezek J, Jezek P (2009) Pro-oxidant mitochondrial matrix-targeted ubiquinone MitoQ10 acts as anti-oxidant at retarded electron transport or proton pumping within Complex I. Int J Biochem Cell Biol 41:1697-707.
Dlaskova 2008 Int J Biochem Cell Biol 2008 Dlasková A, Hlavatá L, Jezek J, Jezek P (2008) Mitochondrial Complex I superoxide production is attenuated by uncoupling. Int J Biochem Cell Biol 40:2098-109.
Hlavata 2008 Aging Cell 2008 Hlavatá L, Nachin L, Jezek P, Nyström T (2008) Elevated Ras/protein kinase A activity in Saccharomyces cerevisiae reduces proliferation rate and lifespan by two different reactive oxygen species-dependent routes. Aging Cell 7:148-57.
Spacek 2008 Int J Biochem Cell Biol 2008 Spacek T, Santorová J, Zacharovová K, Berková Z, Hlavatá L, Saudek F, Jezek P (2008) Glucose-stimulated insulin secretion of insulinoma INS-1E cells is associated with elevation of both respiration and mitochondrial membrane potential. Int J Biochem Cell Biol 40:1522-35.
Zacharovova 2005 Transplant Proc 2005 Zacharovova K, Berkova Z, Spacek T, Kriz J, Dovolilova E, Girman P, Koblas T, Jezek P, Saudek F (2005) In vitro assessment of pancreatic islet vitality by oxymetry. Transplant Proc 37:3454-6.


Abstracts

Published Reference
Jaburek 2014 Abstract MiP2014 2014 The role of phospholipase A2γ in the regulation of mitochondrial uncoupling protein 2–dependent antioxidant function.
Jezek 2014 Abstract MiP2014 2014 Mitochondrial cristae morphology changes: from Hackenbrock to hypoxia.
Plecita-Hlavata 2013 Abstract MiP2013 2013 Plecita-Hlavata L, Engstova H, Spacek T, Alan L, Stradalova V, Malinsky J, Jezek P(2013) Mitochondrial network and cristae remodeling upon hypoxia. Mitochondr Physiol Network 18.08.
Jezek 2013 Abstract MiP2013 2013 Ježek P, Ježek J, Zelenka J, Dlasková A, Jabůrek M (2013) Antioxidant synergy of mitochondrial uncoupling protein UCP2 and phospholipase iPLA2γ. Mitochondr Physiol Network 18.08.
Zelenka J 2013 Abstract MiP2013 2013 Zelenka J, Alan L, Jezek P(2013) Response of cancer cells to mitochondrial DNA damage. Mitochondr Physiol Network 18.08.
Pajuelo-Reguera 2013 Abstract MiP2013 2013 Pajuelo DR, Ježek P, Olejár T, Alán L (2013) Some mitophagy markers in liver and skeletal muscle in Goto Kakizaki rats. Mitochondr Physiol Network 18.08.
Dlaskova 2013 Abstract MiP2013 2013 Dlasková A, Tauber J, Špaček T, Alán L, Ježek P (2013) Distribution of nucleoids of mitochondrial DNA. Mitochondr Physiol Network 18.08.
Zelenka 2013 Abstract MiP2013 2013 Zelenka J, Smolkova K, Dvorak A, Vitek L, Jezek P (2013) Reverse carboxylation glutaminolysis in breast cancer cells. Mitochondr Physiol Network 18.08.

Participated at

CV (Nov 2011)

Born: April 22, 1957; Current job position: Head, Dept. Membrane Transport Biophysics, No.75, Inst.Physiology.

Engaged in the European Union project BIOCEV, Vestec by Prague.

Education: 1981: Faculty of Mathematics and Physics, Charles University, Prague, Czech Republic, graduated in biophysics (title "RNDr" in physics); 1981-1986: a postgraduate fellowship at the Department of Bioenergetics, Institute of Physiology, Acad. Sci., under supervision of Josef Houštek, M.D 1986: Ph.D.-degree in Physiology of animals - Ph.D. thesis: "Ion transport and thermogenesis in brown adipose tissue mitochondria". 2001: achieved D.Sc.-degree (doctor scienciarum) in Physiology of animals (Acad.Sciences and Charles University, Prague). DSc. Thesis: „Mitochondrial uncoupling proteins, anion carriers and ion channels.“

Postdoctoral research training: 1987 Germany - lab. of Prof. Klaus Ring, President Univ. Frankfurt/Main, FRG. 1988-1990: U.S.A., Advanced postdoctoral fellowships in the lab. of Prof. K.D. Garlid at the Dept. Pharmacology, Medical College of Ohio, Toledo, Ohio, U.S.A. 1992: CSIC, CIB, Institute of Biology, Madrid - 8 months. Research and academic positions:

Since 1991: Head of the Department, permanent position of researcher in the Institute of Physiology, Prague; February 1991 formed own Department of Membrane transport Biophysics in this Institute, building completely new laboratory for biofluorescence methods and molecular biology up to present. Recently, he is developing the 3D superresolution microscopy, such as 4Pi microscopy and BiplaneFPALM microscopy.

Dr. P.J. is member of four commissions organizing Ph.D. studies in Czech Republic, supervising many Ph.D. students, several have already graduated under his supervision in biochemistry and biophysics, respectively. Memberships in Editorial Boards: member of the editorial board of the Int.J. Biochem.& Cell Biology (London).

Past achievement: Dr. P. J.: h-index 29; till 2010: >3000 citations, published 91 major scientific papers (total impact factor 351.5, i.e. 13.5 per year since 1984, an average IF 3.86 per paper; among which 18 appeared in the Journal of Biological Chemistry (2 in FASEB J., 1 in Aging Cell, 15 in IJBCB, 6 in BBA, 16 in FEBS Lett., 6 in J. Bioenerg. Biomembr., 3 in Eur. J. Bioch., 2 in Am. J. Physiol., etc.). One Czech and PCT patent (EU applied) in photodynamic therapy of tumors.

Dr. PJ has received numerous foreign grants such as Fogarty Int. grant 1992-1995, & Prof.Garlid, OGI. Portland OR, USA; grant of Czech&US Science & Technology Program 1996-1998, Prof.Garlid, OGI Portland OR, USA; DFG grant 1996-1997, (& Dr. D. Siemen, Univ. Kiel), PRONEX - Brazilian Federal Grant for the Excellence centers – 1998-2002 PIs: Prof. Vercesi, Arruda UNICAMP; DFG grant 2000-2001, (& Dr. P. Pohl, Univ. Halle, SRN); Fogarty International grant 2002-2005,& Garlid, Portland State University, OR, USA. Dr. P.J. has been developing (&colleagues) for past 10 years numerous techniques of modern mol. biology and recently superresolution 3Dimensional fluorescence microscopy.

List of milestone papers (antichronologically): (C = citations without autocitations)

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