CZ Prague Jezek P

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CZ Prague Jezek P

OROBOROS O2k-Network

O2k-Network Lab
Petr Jezek (right) with Rodrigue Rossignol (middle) and Guy Brown (left)

Institute of Physiology

Dept. No. 75

Academy of Sciences of the Czech Republic

Address Videnska 1083, 14220
City Prague
Country Czech Republic
Contact Jezek Petr
Team Dlaskova Andrea, Hlavata Lydie, Jaburek Martin, Jezek Jan, Plecita-Hlavata Lydie, Saudek Frantisek, Smolkova Katharina, Spacek Tomas, Uhrova Katerina, Zelenka Jaroslav, Pajuelo-Reguera David
Team previous
Status 2 Power-O2k 2003-
OROBOROS Events MiP2014, MiP2013, IOC76, IOC39, IOC24
Topics Hydrogen peroxide


Published Reference
Rohlenova 2016 Antioxid Redox Signal 2016 Rohlenova K, Sachaphibulkij K, Stursa J, Bezawork-Geleta A, Blecha J, Endaya B, Werner L, Cerny J, Zobalova R, Goodwin J, Spacek T, Alisadeh E, Yan B, Nguyen M, Vondrusova M, Sobol M, Jezek P, Hozak P, Truksa J, Rohlena J, Dong L, Neuzil J (2016) Selective disruption of respiratory supercomplexes as a new strategy to suppress Her2high breast cancer. Antioxid Redox Signal [Epub ahead of print].
Jezek 2015 Antioxid Redox Signal 2015 Ježek J, Dlasková A, Zelenka J, Jabůrek M, Ježek P (2015) H2O2-Activated Mitochondrial Phospholipase iPLA2γ Prevents Lipotoxic Oxidative Stress in Synergy with UCP2, Amplifies Signaling via G-protein-coupled receptor GPR40, and regulates insulin secretion in pancreatic β-cells. Antioxid Redox Signal 23:958-72.
Zelenka 2015 Oxid Med Cell Longev 2015 Zelenka J, Dvořák A, Alán L (2015) L-lactate protects skin fibroblasts against aging-associated mitochondrial dysfunction via mitohormesis. Oxid Med Cell Longev 2015:351698.
Smolkova 2015 Int J Biochem Cell Biol 2015 Smolková K, Dvořák A, Zelenka J, Vítek L, Ježek P (2015) Reductive carboxylation and 2-hydroxyglutarate formation by wild-type IDH2 in breast carcinoma cells. Int J Biochem Cell Biol 65:125-33.
Plecita-Hlavata 2015 Am J Respir Cell Mol Biol 2015 Plecitá-Hlavatá L, Tauber J, Li M, Zhang H, Flockton AR, Pullamsetti SS, Chelladurai P, D'alessandro A, El Kasmi KC, Ježek P, Stenmark KR (2015) Constitutive reprogramming of fibroblast mitochondrial metabolism in pulmonary hypertension. Am J Respir Cell Mol Biol 55:47-57.
Plecita-Hlavata 2015 J Bioenerg Biomembr 2015 Plecitá-Hlavatá L, Ježek J, Ježek P (2015) Aglycemia keeps mitochondrial oxidative phosphorylation under hypoxic conditions in HepG2 cells. J Bioenerg Biomembr 47(6):467-76.
Konickova 2014 Annals Hepatol 2014 Konickova R, Vankova K, Vanikova J, Vanova K, Muchova L, Subhanova I, Zadoinova M, Zelenka J, Dvorak A, Kolar M,Strnad H, Rimpelova S, Ruml T, Wong RJ, Vitek L (2014) Anti-cancer effects of blue-green alga Spirulina platensis, a natural source of bilirubin-like tetrapyrrolic compounds. Annals Hepatol 13:273-83.
MiPNet18.04 IOC76 2013-05-28
Prague CZ, 2013 May 28-29. O2k-Workshop on high-resolution respirometry, OROBOROS IOC76. O2k-Network Lab »CZ Prague Kalous M.
Jaburek 2013 Int J Biochem Cell Biol 2013 Jabůrek M, Ježek J, Zelenka J, Ježek P (2013) Antioxidant activity by a synergy of redox-sensitive mitochondrial phospholipase A2 and uncoupling protein-2 in lung and spleen. Int J Biochem Cell Biol 45:816-25.
Jezek 2010 Physiol Res 2010 Ježek J, Jabůrek M, Zelenka J, Ježek P (2010) Mitochondrial phospholipase A2 activated by reactive oxygen species in heart mitochondria induces mild uncoupling. Physiol Res 59:737-47.
Smolkova 2010 J Bioenerg Biomembr 2010 Smolková K, Bellance N, Scandurra F, Génot E, Gnaiger E, Plecitá-Hlavatá L, Ježek P, Rossignol R (2010) Mitochondrial bioenergetic adaptations of breast cancer cells to aglycemia and hypoxia. J Bioenerg Biomembr 42:55-67.
Bellance 2009 Int J Biochem Cell Biol 2009 Bellance N, Benard G, Furt F, Begueret H, Smolková K, Passerieux E, Delage JP, Baste JM, Moreau P, Rossignol R (2009) Bioenergetics of lung tumors: Alteration of mitochondrial biogenesis and respiratory capacity. Int J Biochem Cell Biol 41:2566-77.
Plecita-Hlavata 2009 Int J Biochem Cell Biol 2009 Plecita-Hlavata L, Jezek J, Jezek P (2009) Pro-oxidant mitochondrial matrix-targeted ubiquinone MitoQ10 acts as anti-oxidant at retarded electron transport or proton pumping within Complex I. Int J Biochem Cell Biol 41:1697-707.
Dlaskova 2008 Int J Biochem Cell Biol 2008 Dlasková A, Hlavatá L, Jezek J, Jezek P (2008) Mitochondrial Complex I superoxide production is attenuated by uncoupling. Int J Biochem Cell Biol 40:2098-109.
Spacek 2008 Int J Biochem Cell Biol 2008 Spacek T, Santorová J, Zacharovová K, Berková Z, Hlavatá L, Saudek F, Jezek P (2008) Glucose-stimulated insulin secretion of insulinoma INS-1E cells is associated with elevation of both respiration and mitochondrial membrane potential. Int J Biochem Cell Biol 40:1522-35.
Hlavata 2008 Aging Cell 2008 Hlavatá L, Nachin L, Jezek P, Nyström T (2008) Elevated Ras/protein kinase A activity in Saccharomyces cerevisiae reduces proliferation rate and lifespan by two different reactive oxygen species-dependent routes. Aging Cell 7:148-57.
Zacharovova 2005 Transplant Proc 2005 Zacharovova K, Berkova Z, Spacek T, Kriz J, Dovolilova E, Girman P, Koblas T, Jezek P, Saudek F (2005) In vitro assessment of pancreatic islet vitality by oxymetry. Transplant Proc 37:3454-6.


Published Reference
Jaburek 2014 Abstract MiP2014 2014 The role of phospholipase A2γ in the regulation of mitochondrial uncoupling protein 2–dependent antioxidant function.
Jezek 2014 Abstract MiP2014 2014 Mitochondrial cristae morphology changes: from Hackenbrock to hypoxia.
Zelenka J 2013 Abstract MiP2013 2013 Zelenka J, Alan L, Jezek P(2013) Response of cancer cells to mitochondrial DNA damage. Mitochondr Physiol Network 18.08.
Jezek 2013 Abstract MiP2013 2013 Ježek P, Ježek J, Zelenka J, Dlasková A, Jabůrek M (2013) Antioxidant synergy of mitochondrial uncoupling protein UCP2 and phospholipase iPLA2γ. Mitochondr Physiol Network 18.08.
Zelenka 2013 Abstract MiP2013 2013 Zelenka J, Smolkova K, Dvorak A, Vitek L, Jezek P (2013) Reverse carboxylation glutaminolysis in breast cancer cells. Mitochondr Physiol Network 18.08.
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