Drahota Z

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Dr. Zdenek Drahota received from his team in Prague an OROBOROS cake at his 80th birthday
Name Drahota Zdenek, Dr.
Institution Dept. of Bioenergetics

Institute of Physiology

Academy of Sciences of the Czech Rep.

Address Videnska 1083

Prague 4, 14220

City Prague
State/Province
Country Czech Republic
Email drahota@biomed.cas.cz
Weblink
O2k-Network Lab CZ Hradec Kralove Cervinkova Z, CZ Prague Houstek J


Labels: Field of research: Basic 



Publications

Published Reference
Hejzlarova 2015 Biochem J 2015 Hejzlarová K, Kaplanová V, Nůsková H, Kovářová N, Ješina P, Drahota Z, Mráček T, Seneca S, Houštěk J (2015) Alteration of structure and function of ATP synthase and cytochrome c oxidase by lack of Fo-a and Cox3 subunits caused by mitochondrial DNA 9205delTA mutation. Biochem J 466:601-11.
Sobotka 2015 Physiol Res 2015 Sobotka O, Drahota Z, Kučera O, Endlicher R, Rauchová H, Červinková Z (2015) The effect of α-tocopheryl succinate on succinate respiration in rat liver mitochondria. Physiol Res 64 Suppl 5:S609-15.
Kluckova 2015 Cell Death Dis 2015 Kluckova K, Sticha M, Cerny J, Mracek T, Dong L, Drahota Z, Gottlieb E, Neuzil J, Rohlena J (2015) Ubiquinone-binding site mutagenesis reveals the role of mitochondrial complex II in cell death initiation. Cell Death Dis 6:e1749.
Rauchova 2014 Int J Biochem Cell Biol 2014 Rauchová H, Vokurková M, Drahota Z (2014) Inhibition of mitochondrial glycerol-3-phosphate dehydrogenase by α-tocopheryl succinate. Int J Biochem Cell Biol 53:409-13.
Kucera 2014 Oxid Med Cell Longev 2014 Kučera O, Endlicher R, Roušar T, Lotková H, Garnol T, Drahota Z, Cervinková Z (2014) The effect of tert-butyl hydroperoxide-induced oxidative stress on lean and steatotic rat hepatocytes in vitro. Oxid Med Cell Longev 2014:752506.
Drahota 2014 Physiol Res 2014 Drahota Z, Palenickova E, Endlicher R, Milerova M, Brejchova J, Vosahlikova M, Svoboda P, Kazdova L, Kalous M, Cervinkova Z, Cahova M (2014) Biguanides inhibit complex I, II and IV of rat liver mitochondria and modify their functional properties. Physiol Res 63:1-11.
Cahova 2014 Appl Physiol Nutr Metab 2014 Cahova M, Chrastina P, Hansikova H, Drahota Z, Trnovska J, Skop V, Spacilova J, Malinska HOliyarnyk O, Papackova Z, Palenickova E,Kazdova L (2014) Carnitine supplementation alleviates lipid metabolism derangements and protects against oxidative stress in non-obese hereditary hypertriglyceridemic rats. Appl Physiol Nutr Metab 40:280-91.
Drahota 2012 J Bioenerg Biomembr 2012 Drahota Z, Endlicher R, Staňková P, Rychtrmoc D, Milerová M, Cervinková Z (2012) Characterization of calcium, phosphate and peroxide interactions in activation of mitochondrial swelling using derivative of the swelling curves. J Bioenerg Biomembr 44:309-15.
Drahota 2012 Physiol Res 2012 Drahota Z, Milerová M, Endlicher R, Rychtrmoc D, Červinková Z, Ošt'ádal B (2012) Developmental changes of the sensitivity of cardiac and liver mitochondrial permeability transition pore to calcium load and oxidative stress. Physiol Res 61:S165-72.
Palenickova 2011 Physiol Res 2011 Palenickova E, Cahova M, Drahota Z, Kazdova L, Kalous M (2011) Inhibitory effect of metformin on oxidation of NADH-dependent substrates in rat liver homogenate. Physiol Res 60:835-9.
Benes 2011 Clin Sci (Lond) 2011 Benes J, Kazdova L, Drahota Z, Houstek J, Medrikova D, Kopecky J, Kovarova N, Vrbacky M, Sedmera D, Strnad H, Kolar M, Petrak J, Benada O, Skaroupkova P, Cervenka L, Melenovsky V (2011) Effect of metformin therapy on cardiac function and survival in a volume-overload model of heart failure in rats. Clin Sci (Lond) 121:29-41.
Pecinova 2011 Mitochondrion 2011 Pecinova A, Drahota Z, Nuskova H, Pecina P, Houstek J (2011) Evaluation of basic mitochondrial functions using rat tissue homogenates. Mitochondrion 11:722-8.
Havlickova 2010 Biochim Biophys Acta 2010 Havlíčková V, Kaplanová V, Nůsková H, Drahota Z, Houštěk J (2010) Knockdown of F1 epsilon subunit decreases mitochondrial content of ATP synthase 2 and leads to accumulation of subunit c. Biochim Biophys Acta 1797:1124-9.
Nuskova 2010 J Bioenerg Biomembr 2010 Nůsková H, Vrbacký M, Drahota Z, Houštěk J (2010) Cyanide inhibition and pyruvate-induced recovery of cytochrome c oxidase. J Bioenerg Biomembr 42:395-403.
Milerova 2010 Mol Cell Biochem 2010 Milerova M, Charvatova Z, Skarka L, Ostadalova I, Drahota Z, Fialova M, Ostadal B (2010) Neonatal cardiac mitochondria and ischemia/reperfusion injury. Mol Cell Biochem 335:147-53.
Endlicher 2009 Physiol Res 2009 Endlicher R, Kriváková P, Rauchová H, Nůsková H, Cervinková Z, Drahota Z (2009) Peroxidative damage of mitochondrial respiration is substrate-dependent. Physiol Res 58:685-92.
Cervinkova 2009 Arch Toxicol 2009 Cervinková Z, Kriváková P, Lábajová A, Rousar T, Lotková H, Kucera O, Endlicher R, Cervinka M, Drahota Z (2009) Mechanisms participating in oxidative damage of isolated rat hepatocytes. Arch Toxicol 83:363-72.
Cizkova 2008 Nat Genet 2008 Cızkova A, Stranecky V, Mayr JA, Tesarova M, Havlıckova V, Paul J, Ivanek R, Kuss AW, Hansıkova H, Kaplanova W, Vrbacky M, Hartmannova H, Noskova L, Honzık T, Drahota Z, Magner M, Hejzlarova K, Sperl W, Zeman J, Houstek J, Kmoch S (2008) TMEM70 mutations cause isolated ATP synthase deficiency and neonatal mitochondrial encephalocardiomyopathy. Nat Genet 40:1288-90.
Kus 2008 Am J Physiol Endocrinol Metab 2008 Kus V, Prazak T, Brauner P, Hensler M, Kuda O, Flachs P, Janovska P, Medrikova D, Rossmeisl M, Jilkova Z, Stefl B, Pastalkova E, Drahota Z, Houstek J, Kopecky J (2008) Induction of muscle thermogenesis by high-fat diet in mice: Association with obesity-resistance. Am J Physiol Endocrinol Metab 295:356-67.
Rauchova 2008 J Bioenerg Biomembr 2008 Rauchova H, Drahota Z, Bergamini C, Fato R, Lenaz G (2008) Modification of respiratory-chain enzyme activities in brown adipose tissue mitochondria by idebenone (hydroxydecyl-ubiquinone). J Bioenerg Biomembr 40:85-93.
Cervinkova 2008 Physiol Res 2008 Cervinková Z, Rauchová H, Kriváková P, Drahota Z (2008) Inhibition of palmityl carnitine oxidation in rat liver mitochondria by tert-butyl hydroperoxide. Physiol Res 57:133-6.
Vrbacky 2007 Biochim Biophys Acta 2007 Vrbacky M, Drahota Z, Mracek T, Vojtískova A, Jesina P, Stopka P, Houstek J (2007) Respiratory chain components involved in the glycerophosphate dehydrogenase-dependent ROS production by brown adipose tissue mitochondria. Biochim Biophys Acta 1767:989-97.
Cervinkova 2007 Altern Lab Anim 2007 Cervinkova Z, Lotkova H, Krivaikova P, Rousar T, Kucera O, Tichy L, Cervinka M, Drahota Z (2007) Evaluation of mitochondrial function in isolated rat hepatocytes and mitochondria during oxidative stress. Altern Lab Anim 35:353-61.
Krivakova 2007 Physiol Res 2007 Krivakova P, Labajova A, Cervinkova Z, Drahota Z (2007) Inhibitory effect of t-butyl hydroperoxide on mitochondrial oxidative phosphorylation in isolated rat hepatocytes. Physiol Res 56:137-40.
Labajova 2006 Gen Physiol Biophys 2006 Lábajová A, Kofránek J, Kriváková P, Cervinková Z, Drahota Z (2006) Tetraphenylphosphonium-Selective Electrode as a Tool for Evaluating Mitochondrial Permeability Transition Pore Function in Isolated Rat Hepatocytes. Gen Physiol Biophys 25:325-31.
Labajova 2006 Anal Biochem 2006 Labajova A, Vojtiskova A, Krivakova P, Kofranek J, Drahota Z, Houstek J (2006) Evaluation of mitochondrial membrane potential using a computerized device with a tetraphenylphosphonium-selective electrode. Anal Biochem 353:37-42.
Honzik 2006 Placenta 2006 Honzik T, Drahota Z, Bohm M, Jesina P, Mracek T, Paul J, Zeman J, Houstek J (2006) Specific properties of heavy fraction of mitochondria from human-term placenta - Glycerophosphate-dependent hydrogen peroxide production. Placenta 27:348-56.
Drahota 2005 Physiol Res 2005 Drahota Z, Krivakova P, Cervinkova Z, Kmonickova E, Lotkova H, Kucera O, Houstek J (2005) Tert-butyl hydroperoxide selectively inhibits mitochondrial respiratory-chain enzymes in isolated rat hepatocytes. Physiol Res 54:67-72.
Drahota 2005 Cell Biochem Biophys 2005 Drahota Z, Milerova M, Stieglerova A, Skarka L, Houstek J, Ostadal B (2005) Development of cytochrome-c oxidase in rat heart. Cell Biochem Biophys 43:87-94.
Rauchova 2005 Biochem Biophys Res Comm 2005 Rauchova H, Vrbacky M, Bergamini C, Fato R, Lenaz G, Houstek J, Drahota Z (2005) Inhibition of glycerophosphate-dependent H2O2 generation in brown fat mitochondria by idebenone. Biochem Biophys Res Comm 339:362-6.
Jesina 2004 Physiol Res 2004 Jesina P, Kholova D, Bolehovska R, Cervinkova Z, Drahota Z, Houstek J (2004) Glycerophosphate-dependent hydrogen peroxide production by rat liver mitochondria. Physiol Res 53:305-10.
Pecina 2003 Biochim Biophys Acta 2003 Pecina P, Capkova M, Roy Chowdhury SK, Drahota Z, Dubot A, Vojtiskova A, Hansikova H, Houstekova H, Zeman J, Godinot C, Houstek J (2003) Functional alteration of cytochrome c oxidase by SURF1 mutations in Leigh syndrome. Biochim Biophys Acta 1639:53-63.
Kalbacova 2003 Cytometry 2003 Kalbácová M, Vrbacký M, Drahota Z, Melková Z (2003) Comparison of the effect of mitochondrial inhibitors on mitochondrial membrane potential in two different cell lines using flow cytometry and spectrofluorometry. Cytometry 52A:110-6.
Vrbacky 2003 Physiol Res 2003 Vrbacký M, Krijt J, Drahota Z, Mĕlková Z (2003) Inhibitory effects of Bcl-2 on mitochondrial respiration. Physiol Res 52:545-54.
Wenchich 2003 Physiol Res 2003 Wenchich L, Drahota Z, Honzík T, Hansíková H, Tesarová M, Zeman J, Houstek J (2003) Polarographic evaluation of mitochondrial enzymes activity in isolated mitochondria and in permeabilized human muscle cells with inherited mitochondrial defects. Physiol Res 52:781-88.
Rauchova 2003 Acta Biochim Pol 2003 Rauchová H, Drahota Z, Rauch P, Fato R, Lenaz G (2003) Coenzyme Q releases the inhibitory effect of free fatty acids on mitochondrial glycerophosphate dehydrogenase. Acta Biochim Pol 50:405-13.
Drahota 2002 J Bioenerg Biomembr 2002 Drahota Z, Roy Chowdhury SK, Floryk D, Mrácek T, Wilhelm J, Rauchova H, Lenaz G, Houstek J (2002) Glycerophosphate-dependent hydrogen peroxide production by brown adipose tissue mitochondria and ist activation by ferricyanide. J Bioenerg Biomembr 34:105-13.
Roy Chowdhury 2000 Clin Chim Acta 2000 Roy Chowdhury SK, Drahota Z, Floryk D, Calda P, Houstek J (2000) Activities of mitochondrial oxidative phosphorylation enzymes in cultured amniocytes. Clin Chim Acta 298:157-73.


Abstracts

Published Reference
Mracek 2015 Abstract MiP2015 2015 Myocardial iron and mitochondrial function in failing and non-failing human heart: direct tissue analysis.
Rohlena 2015 Abstract MiP2015 2015 Ubiquinone-binding site mutagenesis reveals the role of mitochondrial complex II in cell death initiation.
Kovalcikova 2015 Abstract MiP2015 2015 Derangements of myocardial mitochondrial function in patients with end-stage heart failure is associated with reduced endonuclease G.
Pecinova 2015 Abstract MiP2015 2015 Autocrine effects of transgenic resistin reduce palmitate and glucose oxidation in brown adipose tissue.
Karbanova 2015 Abstract MiP2015 2015 CD36 does not directly participate in mitochondrial fatty acid transport and oxidation.
Houstek 2014 Abstract MiP2014 2014 Alteration of structure and function of ATP synthase and cytochrome c oxidase by lack of Fo-a and Cox3 subunits caused by mitochondrial DNA 9205delTA mutation.
Sobotka 2014 Abstract IOC95 2014 Sobotka O (2014) Effect of α-Tocopheryl succinate on Complex II. Mitochondr Physiol Network 19.10
Mracek 2014 Abstract MiP2014 2014 Function of mitochondrial energy provision apparatus is compromised in patients with chronic heart failure. Mitochondr Physiol Network 19.13.
Cervinkova 2012 Abstract Bioblast 2012 Cervinkova Z, Stankova P, Cervinka M, Kucera O, Drahota Z (2012) Evaluation of mitochondrial functions – an important tool for experimental hepatology. Mitochondr Physiol Network 17.12.

O2k-Workshops

2012-09-16: Happy birthday to Dr. Zdenek Drahota - 80 active years - and many more!!
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