CZ Hradec Kralove Cervinkova Z

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CZ Hradec Kralove Cervinkova Z

OROBOROS O2k-Network

O2k-Network
O2k-Network Lab Department of Physiology

Faculty of Medicine, Charles University in Prague

Address Simkova 870, 500 38
City Hradec Kralove
State/Prov
Country Czech Republic
Weblink
Contact Cervinkova Zuzana
Team Cervinka Miroslav, Drahota Zdenek, Endlicher Rene, Kucera Otto, Lotkova Halka, Sobotka Ondrej, Stankova Pavla
Team previous Rousar Tomas
Status 3 Power-O2k 2002-
OROBOROS Events IOC100, IOC95, IOC76, Bioblast 2012, IOC41, IOC31, IOC21
Topics Liver cells, Liver regeneration, Toxic liver injury in vivo and in vitro


O2k-Publications

Published Reference
Milerova 2016 Mol Cell Biochem 2016 Milerová M, Drahota Z, Chytilová A, Tauchmannová K, Houštěk J, Ošťádal B (2016) Sex difference in the sensitivity of cardiac mitochondrial permeability transition pore to calcium load. Mol Cell Biochem 412:147-54.
Hejzlarova 2015 Biochem J 2015 Hejzlarová K, Kaplanová V, Nůsková H, Kovářová N, Ješina P, Drahota Z, Mráček T, Seneca S, Houštěk J (2015) Alteration of structure and function of ATP synthase and cytochrome c oxidase by lack of Fo-a and Cox3 subunits caused by mitochondrial DNA 9205delTA mutation. Biochem J 466:601-11.
Kluckova 2015 Cell Death Dis 2015 Kluckova K, Sticha M, Cerny J, Mracek T, Dong L, Drahota Z, Gottlieb E, Neuzil J, Rohlena J (2015) Ubiquinone-binding site mutagenesis reveals the role of mitochondrial complex II in cell death initiation. Cell Death Dis 6:e1749.
Sobotka 2015 Physiol Res 2015 Sobotka O, Drahota Z, Kučera O, Endlicher R, Rauchová H, Červinková Z (2015) The effect of α-tocopheryl succinate on succinate respiration in rat liver mitochondria. Physiol Res 64 Suppl 5:S609-15.
Kucera 2014 Oxid Med Cell Longev 2014 Kučera O, Endlicher R, Roušar T, Lotková H, Garnol T, Drahota Z, Cervinková Z (2014) The effect of tert-butyl hydroperoxide-induced oxidative stress on lean and steatotic rat hepatocytes in vitro. Oxid Med Cell Longev 2014:752506.
Rauchova 2014 Int J Biochem Cell Biol 2014 Rauchová H, Vokurková M, Drahota Z (2014) Inhibition of mitochondrial glycerol-3-phosphate dehydrogenase by α-tocopheryl succinate. Int J Biochem Cell Biol 53:409-13.
Drahota 2014 Physiol Res 2014 Drahota Z, Palenickova E, Endlicher R, Milerova M, Brejchova J, Vosahlikova M, Svoboda P, Kazdova L, Kalous M, Cervinkova Z, Cahova M (2014) Biguanides inhibit complex I, II and IV of rat liver mitochondria and modify their functional properties. Physiol Res 63:1-11.
MiPNet18.04 IOC76 2013-05-28
O2k-Network
Prague CZ, 2013 May 28-29. O2k-Workshop on high-resolution respirometry, OROBOROS IOC76. O2k-Network Lab »CZ Prague Kalous M.
Drahota 2012 Physiol Res 2012 Drahota Z, Milerová M, Endlicher R, Rychtrmoc D, Červinková Z, Ošt'ádal B (2012) Developmental changes of the sensitivity of cardiac and liver mitochondrial permeability transition pore to calcium load and oxidative stress. Physiol Res 61:S165-72.
Jirkovsky 2012 J Pharmacol Exp Ther 2012 Jirkovsky E, Popelová O, Kriváková-Stanková P, Vávrová A, Hroch M, Hasková P, Brcáková-Dolezelová E, Micuda S, Adamcová M, Simůnek T, Cervinková Z, Gersl V, Sterba M (2012) Chronic anthracycline cardiotoxicity: molecular and functional analysis with focus on nuclear factor erythroid 2-related factor 2 and mitochondrial biogenesis pathways. J Pharmacol Exp Ther 343:468-78.
Kucera 2012 J Gastroenterol Hepatol 2012 Kucera O, Rousar T, Stankova P, Hanackova L, Lotkova H, Podhola M, Cervinkova Z (2012) Susceptibility of rat non-alcoholic fatty liver to the acute toxic effect of acetaminophen. J Gastroenterol Hepatol 27:323-30.
Lotkova 2011 Gen Physiol Biophys 2011 Lotková H, Staňková P, Roušar T, Kučera O, Kohoutek L, Mičuda S, Brčáková E, Kolouchová G, Cervinková Z (2011) Deteriorating effect of fluvastatin on the cholestatic liver injury induced by bile duct ligation in rats. Gen Physiol Biophys 30:66-74.
Kucera 2011 Physiol Res 2011 Kučera O, Garnol T, Lotková H, Staňková P, Mazurová Y, Hroch M, Bolehovská R, Roušar T, Červinková Z (2011) The effect of rat strain, diet composition and feeding period on the development of a nutritional model of non-alcoholic fatty liver disease in rats. Physiol Res 60:317-28.
Kucera 2011 Int J Exp Pathol 2011 Kučera O, Lotková H, Staňková P, Podhola M, Roušar T, Mezera V, Cervinková Z (2011) Is rat liver affected by non-alcoholic steatosis more susceptible to the acute toxic effect of thioacetamide?. Int J Exp Pathol 92:281-9.
Pecinova 2011 Mitochondrion 2011 Pecinova A, Drahota Z, Nuskova H, Pecina P, Houstek J (2011) Evaluation of basic mitochondrial functions using rat tissue homogenates. Mitochondrion 11:722-8.
Nuskova 2010 J Bioenerg Biomembr 2010 Nůsková H, Vrbacký M, Drahota Z, Houštěk J (2010) Cyanide inhibition and pyruvate-induced recovery of cytochrome c oxidase. J Bioenerg Biomembr 42:395-403.
Milerova 2010 Mol Cell Biochem 2010 Milerova M, Charvatova Z, Skarka L, Ostadalova I, Drahota Z, Fialova M, Ostadal B (2010) Neonatal cardiac mitochondria and ischemia/reperfusion injury. Mol Cell Biochem 335:147-53.
Stankova 2010 Toxicol In Vitro 2010 Staňková P, Kučera O, Lotková H, Roušar T, Endlicher R, Cervinková Z (2010) The toxic effect of thioacetamide on rat liver in vitro. Toxicol In Vitro 24:2097-2103.
Havlickova 2010 Biochim Biophys Acta 2010 Havlíčková V, Kaplanová V, Nůsková H, Drahota Z, Houštěk J (2010) Knockdown of F1 epsilon subunit decreases mitochondrial content of ATP synthase 2 and leads to accumulation of subunit c. Biochim Biophys Acta 1797:1124-9.
Cervinkova 2009 Arch Toxicol 2009 Cervinková Z, Kriváková P, Lábajová A, Rousar T, Lotková H, Kucera O, Endlicher R, Cervinka M, Drahota Z (2009) Mechanisms participating in oxidative damage of isolated rat hepatocytes. Arch Toxicol 83:363-72.
Endlicher 2009 Physiol Res 2009 Endlicher R, Kriváková P, Rauchová H, Nůsková H, Cervinková Z, Drahota Z (2009) Peroxidative damage of mitochondrial respiration is substrate-dependent. Physiol Res 58:685-92.
Lotkova 2009 Acta Vet Brno 2009 Lotková H, Kučera O, Roušar T, Endlicher R, Křiváková P, Garnol T, Červinková Z (2009) Effect of S-adenosylmethionine on Acetaminophen-induced toxic injury of rat hepatocytes in vitro. Acta Vet Brno 78:603-13.
Rauchova 2008 J Bioenerg Biomembr 2008 Rauchova H, Drahota Z, Bergamini C, Fato R, Lenaz G (2008) Modification of respiratory-chain enzyme activities in brown adipose tissue mitochondria by idebenone (hydroxydecyl-ubiquinone). J Bioenerg Biomembr 40:85-93.
Cervinkova 2008 Physiol Res 2008 Cervinková Z, Rauchová H, Kriváková P, Drahota Z (2008) Inhibition of palmityl carnitine oxidation in rat liver mitochondria by tert-butyl hydroperoxide. Physiol Res 57:133-6.
Cizkova 2008 Nat Genet 2008 Cızkova A, Stranecky V, Mayr JA, Tesarova M, Havlıckova V, Paul J, Ivanek R, Kuss AW, Hansıkova H, Kaplanova W, Vrbacky M, Hartmannova H, Noskova L, Honzık T, Drahota Z, Magner M, Hejzlarova K, Sperl W, Zeman J, Houstek J, Kmoch S (2008) TMEM70 mutations cause isolated ATP synthase deficiency and neonatal mitochondrial encephalocardiomyopathy. Nat Genet 40:1288-90.
Kus 2008 Am J Physiol Endocrinol Metab 2008 Kus V, Prazak T, Brauner P, Hensler M, Kuda O, Flachs P, Janovska P, Medrikova D, Rossmeisl M, Jilkova Z, Stefl B, Pastalkova E, Drahota Z, Houstek J, Kopecky J (2008) Induction of muscle thermogenesis by high-fat diet in mice: Association with obesity-resistance. Am J Physiol Endocrinol Metab 295:356-67.
Cervinkova 2007 Altern Lab Anim 2007 Cervinkova Z, Lotkova H, Krivaikova P, Rousar T, Kucera O, Tichy L, Cervinka M, Drahota Z (2007) Evaluation of mitochondrial function in isolated rat hepatocytes and mitochondria during oxidative stress. Altern Lab Anim 35:353-61.
Krivakova 2007 Physiol Res 2007 Krivakova P, Labajova A, Cervinkova Z, Drahota Z (2007) Inhibitory effect of t-butyl hydroperoxide on mitochondrial oxidative phosphorylation in isolated rat hepatocytes. Physiol Res 56:137-40.
Vrbacky 2007 Biochim Biophys Acta 2007 Vrbacky M, Drahota Z, Mracek T, Vojtískova A, Jesina P, Stopka P, Houstek J (2007) Respiratory chain components involved in the glycerophosphate dehydrogenase-dependent ROS production by brown adipose tissue mitochondria. Biochim Biophys Acta 1767:989-97.
Labajova 2006 Gen Physiol Biophys 2006 Lábajová A, Kofránek J, Kriváková P, Cervinková Z, Drahota Z (2006) Tetraphenylphosphonium-Selective Electrode as a Tool for Evaluating Mitochondrial Permeability Transition Pore Function in Isolated Rat Hepatocytes. Gen Physiol Biophys 25:325-31.
Labajova 2006 Anal Biochem 2006 Labajova A, Vojtiskova A, Krivakova P, Kofranek J, Drahota Z, Houstek J (2006) Evaluation of mitochondrial membrane potential using a computerized device with a tetraphenylphosphonium-selective electrode. Anal Biochem 353:37-42.
Honzik 2006 Placenta 2006 Honzik T, Drahota Z, Bohm M, Jesina P, Mracek T, Paul J, Zeman J, Houstek J (2006) Specific properties of heavy fraction of mitochondria from human-term placenta - Glycerophosphate-dependent hydrogen peroxide production. Placenta 27:348-56.
Drahota 2005 Physiol Res 2005 Drahota Z, Krivakova P, Cervinkova Z, Kmonickova E, Lotkova H, Kucera O, Houstek J (2005) Tert-butyl hydroperoxide selectively inhibits mitochondrial respiratory-chain enzymes in isolated rat hepatocytes. Physiol Res 54:67-72.
Jesina 2004 Physiol Res 2004 Jesina P, Kholova D, Bolehovska R, Cervinkova Z, Drahota Z, Houstek J (2004) Glycerophosphate-dependent hydrogen peroxide production by rat liver mitochondria. Physiol Res 53:305-10.
Rauchova 2003 Acta Biochim Pol 2003 Rauchová H, Drahota Z, Rauch P, Fato R, Lenaz G (2003) Coenzyme Q releases the inhibitory effect of free fatty acids on mitochondrial glycerophosphate dehydrogenase. Acta Biochim Pol 50:405-13.
Pecina 2003 Biochim Biophys Acta 2003 Pecina P, Capkova M, Roy Chowdhury SK, Drahota Z, Dubot A, Vojtiskova A, Hansikova H, Houstekova H, Zeman J, Godinot C, Houstek J (2003) Functional alteration of cytochrome c oxidase by SURF1 mutations in Leigh syndrome. Biochim Biophys Acta 1639:53-63.
Vrbacky 2003 Physiol Res 2003 Vrbacký M, Krijt J, Drahota Z, Mĕlková Z (2003) Inhibitory effects of Bcl-2 on mitochondrial respiration. Physiol Res 52:545-54.
Kalbacova 2003 Cytometry 2003 Kalbácová M, Vrbacký M, Drahota Z, Melková Z (2003) Comparison of the effect of mitochondrial inhibitors on mitochondrial membrane potential in two different cell lines using flow cytometry and spectrofluorometry. Cytometry 52A:110-6.
Wenchich 2003 Physiol Res 2003 Wenchich L, Drahota Z, Honzík T, Hansíková H, Tesarová M, Zeman J, Houstek J (2003) Polarographic evaluation of mitochondrial enzymes activity in isolated mitochondria and in permeabilized human muscle cells with inherited mitochondrial defects. Physiol Res 52:781-88.
Drahota 2002 J Bioenerg Biomembr 2002 Drahota Z, Roy Chowdhury SK, Floryk D, Mrácek T, Wilhelm J, Rauchova H, Lenaz G, Houstek J (2002) Glycerophosphate-dependent hydrogen peroxide production by brown adipose tissue mitochondria and ist activation by ferricyanide. J Bioenerg Biomembr 34:105-13.
Roy Chowdhury 2000 Clin Chim Acta 2000 Roy Chowdhury SK, Drahota Z, Floryk D, Calda P, Houstek J (2000) Activities of mitochondrial oxidative phosphorylation enzymes in cultured amniocytes. Clin Chim Acta 298:157-73.


O2k-Abstracts

Published Reference
Mracek 2014 Abstract MiP2014 2014 Function of mitochondrial energy provision apparatus is compromised in patients with chronic heart failure. Mitochondr Physiol Network 19.13.
Sobotka 2014 Abstract IOC95 2014 Sobotka O (2014) Effect of α-Tocopheryl succinate on Complex II. Mitochondr Physiol Network 19.10
Cervinkova 2012 Abstract Bioblast 2012 Cervinkova Z, Stankova P, Cervinka M, Kucera O, Drahota Z (2012) Evaluation of mitochondrial functions – an important tool for experimental hepatology. Mitochondr Physiol Network 17.12.


O2k-Network

Ondrej Sobotka: Visiting scientist at the OROBOROS MitoFit Laboratory within the framework of the Mobility fund of the Charles University from March 01 to June 10 2016.

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