View source for Xing 2022 Atlantis Press

{{Publication
|title=Xing Yunxie (2022) Is genome instability a significant cause of aging? A review. Advances in Social Science, Education and Humanities Research 664, Atlantis Press. https://doi.org/10.2991/assehr.k.220504.260
|info=[https://www.atlantis-press.com/proceedings/ichssr-22/125974698 Atlantis Press]
|authors=Xing Yunxie
|year=2022
|journal=Advances in Social Science, Education and Humanities Research, Atlantis Press
|abstract=What is the main cause of aging has been discussed over last decades. Accumulating evidences has indicated that genome instability including mitochondrial DNA in somatic cell played an important role in human aging process. Various sources of damage such as reactive oxygen species and UV radiation can lead to the decrease of DNA robustness. In addition, the erroneous replication and failure in DNA maintenance system is also able to casus mutations and epimutations. In this review we will first summarize the relation between the accumulation of DNA damage and longevity. Then we will review the contribution made by mitochondrial free radical to the aging process. Finally, we will briefly discuss whether the telomere is an eligible biomarker of life span.
|editor=Gnaiger E
}}
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{{Labeling
|enzymes=Complex II;succinate dehydrogenase
}}