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COST Action CA15203 (2016-2021): MitoEAGLE
Evolution-Age-Gender-Lifestyle-Environment: mitochondrial fitness mapping
The protonmotive force and respiratory control
- » WG1 Action - WG1 MITOEAGLE protocols, terminology, documentation: Standard operating procedures and user requirement document: Protocols, terminology, documentation
- » WG1 Project application
Mitochondrial respiratory coupling control - a conceptual perspective on terminology
- Scope of MITOEAGLE publication: Respiratory states
- Target a broad audience – also the new generation
- List of terms including historical terms; abbreviations (mtDNA, mt to abbreviate mitochondr*); OXPHOS capacity versus State 3 (discuss saturating ADP/Pi .. concentrations)
- Scientific terminology should be general and platform independent - demands of the working groups
- Scope of MITOEAGLE publication: Respiratory states
- Structure
- From bioenergetics to mitochondrial physiology - historical view
- The mitochondrial respiratory system
- Rates and states - Units (important for a database); analogous to electic terms: Flow [C.s-1]; Flux [C.s-1.m-2]; Rate (?)
- Intact cells, mt preparation and normalization
- Coupling states: mt-preparations and intact cells
- Pathway states: mt-preparations and intact cells
- References
- Structure
- Journal
- Int J Biochem Cell Biol (W Koopman will be the new editor); Open Access is a requirement
- Journal
Action
References
- Cohen ER, Cvitas T, Frey JG, Holmström B, Kuchitsu K, Marquardt R, Mills I, Pavese F, Quack M, Stohner J, Strauss HL, Takami M, Thor HL (2008) Quantities, Units and Symbols in Physical Chemistry, IUPAC Green Book, 3rd Edition, 2nd Printing, IUPAC & RSC Publishing, Cambridge. - »Bioblast link«
- Gnaiger E (1993) Nonequilibrium thermodynamics of energy transformations. Pure Appl Chem 65:1983-2002. - »Bioblast link«
- Gnaiger 2014 MitoPathways
- International Union of Biochemistry and Molecular Biology: Recommendations for terminology and databases for biochemical thermodynamics. - »Open Access«
- International Union of Biochemistry (1981) Symbolism and terminology in enzyme kinetics. - »Open Access«
- Lemieux H, Blier PU, Gnaiger E (2017) Remodeling pathway control of oxidative phosphorylation by temperature in the heart. bioRxiv doi10.1101/103457. - »Bioblast link«
- Miller 1991 Scientific American Library
Next steps
- Mitochondrial respiratory pathway control - substrates and inhibitors
- Switch to pathway-related nomenclature instead of enzyme-linked terminology (N/NS/S versus CI/CI+II/CII)
- Mitochondrial respiratory pathway control - substrates and inhibitors