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COST Action CA15203 (2016-2021): MitoEAGLE
Evolution-Age-Gender-Lifestyle-Environment: mitochondrial fitness mapping
The protonmotive force and respiratory control
- » WG1 Action - WG1 MITOEAGLE protocols, terminology, documentation: Standard operating procedures and user requirement document: Protocols, terminology, documentation
- » WG1 Project application
Mitochondrial respiratory coupling control - a conceptual perspective on terminology
- Scope of MITOEAGLE publication: Respiratory states
- Target a broad audience – also the new generation
- List of terms including historical terms; abbreviations (mtDNA, mt to abbreviate mitochondr*); move to pathway related nomenclature instead of using CI+/CI+II/CII; OXPHOS capacity (discuss saturating ADP/Pi .. concentrations)
- Scientific terminology should be general and platform independent - demands of the working groups
- Scope of MITOEAGLE publication: Respiratory states
- Structure
- From bioenergetics to mitochondrial physiology - historical view
- The mitochondrial respiratory system
- Rates and states - Units (important for a database); analogous to electic terms: Flow [C.s-1]; Flux [C.s-1.m-2]; Rate (?)
- Intact cells, mt preparation and normalization
- Coupling states: mt-preparations and intact cells
- Pathway states: mt-preparations and intact cells
- References
- Structure
- Journal
- Int J Biochem Cell Biol (W Koopman will be the new editor); Open Access is a requirement
- Journal
Action
References
- Lemieux H, Blier PU, Gnaiger E (2017) Remodeling pathway control of oxidative phosphorylation by temperature in the heart. bioRxiv doi10.1101/103457. - »Bioblast link«
- Miller 1991 Scientific American Library
- http://www.nature.com/cdd/journal/v16/n1/full/cdd2008150a.html
- http://www.nature.com/cdd/journal/v20/n7/full/cdd201327a.html
