NS-pathway control state: Difference between revisions
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{{MitoPedia | {{MitoPedia | ||
|abbr= | |abbr=NS-state | ||
|description=The '''Complex I<small>&</small>II-linked substrate state''' is induced in mt-preparations by addition of [[NADH]]-generating substrates (CI-linked) in combination with succinate (CII-linked). This physiological substrate combination is required for partial reconstiturion of [[TCA cycle]] function and convergent electron-input into the [[Q-junction]] to compensate for metabolite depletion into the incubation medium. An [[Additive effect of convergent CI&II electron flow]] is observed in most types of mitochondria. | |description=The '''Complex I<small>&</small>II-linked substrate state''' is induced in mt-preparations by addition of [[NADH]]-generating substrates (CI-linked) in combination with succinate (CII-linked). This physiological substrate combination is required for partial reconstiturion of [[TCA cycle]] function and convergent electron-input into the [[Q-junction]] to compensate for metabolite depletion into the incubation medium. An [[Additive effect of convergent CI&II electron flow]] is observed in most types of mitochondria. | ||
|info=[[Gnaiger 2014 MitoPathways]] | |info=[[Gnaiger 2014 MitoPathways]] | ||
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|mitopedia topic=Substrate and metabolite | |mitopedia topic=Substrate and metabolite | ||
}} | }} | ||
= List of publications: CI<small>&</small>II-linked substrate state = | = List of publications: NS- or CI<small>&</small>II-linked substrate state = | ||
{{#ask:[[Category:Publications]] [[Substrate states::CI&II]] | {{#ask:[[Category:Publications]] [[Substrate states::CI&II]] | ||
|?Was published in year=Year | |?Was published in year=Year |
Revision as of 19:54, 20 March 2016
Description
The Complex I&II-linked substrate state is induced in mt-preparations by addition of NADH-generating substrates (CI-linked) in combination with succinate (CII-linked). This physiological substrate combination is required for partial reconstiturion of TCA cycle function and convergent electron-input into the Q-junction to compensate for metabolite depletion into the incubation medium. An Additive effect of convergent CI&II electron flow is observed in most types of mitochondria.
Abbreviation: NS-state
Reference: Gnaiger 2014 MitoPathways
MitoPedia concepts:
Respiratory state
MitoPedia O2k and high-resolution respirometry: "SUIT state" is not in the list (O2k hardware, DatLab, Oroboros QM, O2k-Open Support, O2k-Respirometry, O2k-FluoRespirometry) of allowed values for the "MitoPedia O2k and high-resolution respirometry" property. SUIT state"SUIT state" is not in the list (O2k hardware, DatLab, Oroboros QM, O2k-Open Support, O2k-Respirometry, O2k-FluoRespirometry) of allowed values for the "MitoPedia O2k and high-resolution respirometry" property.
MitoPedia topics:
Substrate and metabolite