- high-resolution terminology - matching measurements at high-resolution
NS-pathway control state
Description
NS-pathway control is exerted in the NS-linked substrate state (flux in the NS-linked substrate state, NS; or Complex I&II, CI&II-linked substrate state). NS-OXPHOS capacity provides an estimate of physiologically relevant maximum mitochondrial respiratory capacity. NS is induced in mt-preparations by addition of NADH-generating substrates (N-pathway control state in combination with succinate (Succinate pathway; S). Whereas NS expresses substrate control in terms of substrate types (N and S), CI&II defines the same concept in terms of convergent electron transfer to the Q-junction (pathway control). NS is the abbreviation for the combination of NADH-linked substrates (N) and succinate (S). This physiological substrate combination is required for partial reconstitution of TCA cycle function and convergent electron-input into the Q-junction, to compensate for metabolite depletion into the incubation medium. NS in combination exerts an additive effect of convergent electron flow in most types of mitochondria.
Abbreviation: NS, CI&II
Reference: Electron-transfer-pathway state, Gnaiger 2020 BEC MitoPathways, Gnaiger_2009_Int J Biochem Cell Biol
- More details
Communicated by Gnaiger E 2014-07-28 (edited 2016-11-08, Komlodi T 2019-01-22, Gnaiger E 2023-11-25).
NSL
NS pathway in the LEAK state can be evaluated in the following SUIT protocols:
NSP
NS pathway in the OXPHOS state can be evaluated in the following SUIT protocols:
- SUIT-008: N{PM}P, N{PGM}P, N{PGM}SP
- DL-Protocol for permeabilized fibers (pfi): SUIT-008 O2 pfi D014
- DL-Protocol for permeabilized cells (pce): SUIT-008 O2 ce-pce D025
- SUIT-009: SP, N{P}SP, SP
- DL-Protocol for isolated mitochondria and tissue homogenate (mt): SUIT-009 O2 mt D015 and SUIT-009 AmR mt D021 for Amplex UltraRed assay.
- DL-Protocol for permeabilized cells (pce): SUIT-009 O2 ce-pce D016 and SUIT-009 AmR ce-pce D019 for Amplex UltraRed assay.
NSE
NS pathway in the ET state can be evaluated in the following SUIT protocols:
- SUIT-001: N{PGM}E, N{PGM}SE, F{Oct}N{PGM}SE, SE, SGpE
- DL-Protocol for isolated mitochondria and tissue homogenate (mt): SUIT-001 O2 mt D001
- DL-Protocol for permeabilized fibers (pfi): SUIT-001 O2 pfi D002
- DL-Protocol for permeabilized cells (pce): SUIT-001 O2 ce-pce D003
- DL-Protocol for permeabilized PBMC and PLT: SUIT-001 O2 ce-pce D004
- SUIT-004: N{PM}E, N{PM}SE, SE
- DL-Protocol for permeabilized fibers (pfi): SUIT-004 O2 pfi D010
- SUIT-008: N{PGM}SE, SE
- DL-Protocol for permeabilized fibers (pfi): SUIT-008 O2 pfi D014
- DL-Protocol for permeabilized cells (pce): SUIT-008 O2 ce-pce D025
- »Publications: NS-pathway control state
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- » Publication count on NS-pathway control state: 1664
| Year | Reference | Coupling | Pathway | Preparation | Organism | Tissue;cell | |
|---|---|---|---|---|---|---|---|
| Cefis 2024 Acta Physiol (Oxf) | 2024 | Cefis M, Dargegen M, Marcangeli V, Taherkhani S, Dulac M, Leduc-Gaudet JP, Mayaki D, Hussain SNA, Gouspillou G (2024) MFN2 overexpression in skeletal muscles of young and old mice causes a mild hypertrophy without altering mitochondrial respiration and H2O2 emission. Acta Physiol (Oxf) [Epub ahead of print]. https://doi.org/10.1111/apha.14119 | LEAK OXPHOS | N NS ROX | Permeabilized tissue | Mouse | Skeletal muscle |
| Liepinsh 2024 Br J Pharmacol | 2024 | Liepinsh E, Zvejniece L, Clemensson L, Ozola M, Vavers E, Cirule H, Korzh S, Skuja S, Groma V, Briviba M, Grinberga S, Liu W, Olszewski P, Gentreau M, Fredriksson R, Dambrova M, Schiöth HB (2024) Hydroxymethylglutaryl-CoA reductase activity is essential for mitochondrial β-oxidation of fatty acids to prevent lethal accumulation of long-chain acylcarnitines in the mouse liver. Br J Pharmacol [Epub ahead of print]. https://doi.org/10.1111/bph.16363 | ET LEAK OXPHOS | F N S NS ROX | Homogenate | Mouse | Liver |
| Lhuissier 2024 iScience | 2024 | Lhuissier C, Desquiret-Dumas V, Girona A, Alban J, Faure J, Cassereau J, Codron P, Lenaers G, Baris OR, Gueguen N, Chevrollier A (2024) Mitochondrial F0F1-ATP synthase governs the induction of mitochondrial fission. iScience 27:109808. https://doi.org/10.1016/j.isci.2024.109808 | LEAK ROUTINE OXPHOS ET | N NS ROX | Permeabilized cells Intact cells | Mouse | Fibroblast |
| Garcia-Poyatos 2024 Dev Cell | 2024 | García-Poyatos C, Arora P, Calvo E, Marques IJ, Kirschke N, Galardi-Castilla M, Lembke C, Meer M, Fernández-Montes P, Ernst A, Haberthür D, Hlushchuk R, Vázquez J, Vermathen P, Enríquez JA, Mercader N (2024) Cox7a1 controls skeletal muscle physiology and heart regeneration through complex IV dimerization. Dev Cell [Epub ahead of print]. https://doi.org/10.1016/j.devcel.2024.04.012 | LEAK OXPHOS | N S CIV NS ROX | Isolated mitochondria | Zebrafish | Skeletal muscle |
| Jacovetti 2024 Mol Metab | 2024 | Jacovetti C, Donnelly C, Menoud V, Suleiman M, Cosentino C, Sobel J, Wu K, Bouzakri K, Marchetti P, Guay C, Kayser B, Regazzi R (2024) The mitochondrial tRNA-derived fragment, mt-tRF-LeuTAA, couples mitochondrial metabolism to insulin secretion. Mol Metab 84:101955. https://doi.org/10.1016/j.molmet.2024.101955 | LEAK OXPHOS | N S NS ROX | Permeabilized cells | Rat | Islet cell;pancreas;thymus |
| Hu 2024 Ecotoxicol Environ Saf | 2024 | Hu R, Fan W, Li S, Zhang G, Zang L, Qin L, Li R, Chen R, Zhang L, Gu W, Zhang Y, Rajagopalan S, Sun Q, Liu C (2024) PM2.5-induced cellular senescence drives brown adipose tissue impairment in middle-aged mice. Ecotoxicol Environ Saf 278:116423. https://doi.org/10.1016/j.ecoenv.2024.116423 | LEAK OXPHOS ET | N S CIV NS ROX | Homogenate | Mouse | Fat |
| Gnaiger 2024 MitoFit | 2024 | Gnaiger E (2024) Addressing the ambiguity crisis in bioenergetics and thermodynamics. MitoFit Preprints 2024.3. https://doi.org/10.26124/mitofit:2024-0003 | LEAK OXPHOS ET | NS | |||
| Ciccone 2024 J Exp Biol | 2024 | Ciccone C, Kante F, Folkow LP, Hazlerigg DG, West AC, Wood SH (2024) Circadian coupling of mitochondria in a deep-diving mammal. J Exp Biol 227:jeb24699. https://doi.org/10.1242/jeb.246990 | LEAK ROUTINE OXPHOS ET | N S NS | Permeabilized cells Intact cells | Other mammals | Fibroblast |
| Mahapatra 2024 J Gerontol A Biol Sci Med Sci | 2024 | Mahapatra G, Gao Z, Bateman JR 3rd, Lockhart SN, Bergstrom J, Piloso JE, Craft S, Molina AJA (2024) Peripheral blood cells from older adults exhibit sex-associated differences in mitochondrial function. J Gerontol A Biol Sci Med Sci [Epub ahead of print]. https://doi.org/10.1093/gerona/glae098 | ROUTINE OXPHOS ET | F N Gp CIV NS Other combinations ROX | Permeabilized cells Intact cells | Human | Blood cells |
| Natsui 2024 Physiol Rep | 2024 | Natsui H, Watanabe M, Yokota T, Tsuneta S, Fumoto Y, Handa H, Shouji M, Koya J, Nishino K, Tatsuta D, Koizumi T, Kadosaka T, Nakao M, Koya T, Temma T, Ito YM, Kanako HC, Hatanaka Y, Yasushige S, Wakasa S, Miura S, Masuda T, Nishioka N, Naraoka S, Ochi K, Kudo T, Ishikawa T, Anzai T (2024) Influence of epicardial adipose tissue inflammation and adipocyte size on postoperative atrial fibrillation in patients after cardiovascular surgery. Physiol Rep 12:e15957. https://doi.org/10.14814/phy2.15957 | LEAK OXPHOS ET | F N NS | Permeabilized tissue | Human | Fat |
| Hunter-Manseau 2024 Insect Sci | 2024 | Hunter-Manseau F, Cormier SB, Strang R, Pichaud N (2024) Fasting as a precursor to high-fat diet enhances mitochondrial resilience in Drosophila melanogaster. Insect Sci [Epub ahead of print]. https://doi.org/10.1111/1744-7917.13355 | LEAK OXPHOS ET | N S Gp NS Other combinations ROX | Permeabilized tissue | Drosophila | |
| Tsouka 2024 Commun Med (Lond) | 2024 | Tsouka S, Kumar P, Seubnooch P, Freiburghaus K, St-Pierre M, Dufour JF, Masoodi M (2024) Transcriptomics-driven metabolic pathway analysis reveals similar alterations in lipid metabolism in mouse MASH model and human. Commun Med (Lond) 4:39. https://doi.org/10.1038/s43856-024-00465-3 | LEAK OXPHOS ET | N S CIV NS ROX | Isolated mitochondria | Mouse | Liver |
| Kim 2024 J Exerc Rehabil | 2024 | Kim TW, Park SS, Kim SH, Kim MK, Shin MS, Kim SH (2024) Exercise before pregnancy exerts protective effect on prenatal stress-induced impairment of memory, neurogenesis, and mitochondrial function in offspring. J Exerc Rehabil 20:2-10. https://doi.org/10.12965/jer.2448068.034 | LEAK OXPHOS | N NS | Mouse | Nervous system | |
| Lavorato 2024 JCI Insight | 2024 | Lavorato M, Iadarola D, Remes C, Kaur P, Broxton C, Mathew ND, Xiao R, Seiler C, Nakamaru-Ogiso E, Anderson VE, Falk MJ (2024) dldhcri3 zebrafish exhibited altered mitochondrial ultrastructure, morphology and dysfunction partially rescued by probucol or thiamine. JCI Insight [Epub ahead of print]. https://doi.org/10.1172/jci.insight.178973 | ET LEAK ROUTINE OXPHOS | N S NS ROX CIV | Homogenate | Zebrafish | |
| Donnelly 2024 Redox Biol | 2024 | Donnelly C, Komlódi T, Cecatto C, Cardoso LHD, Compagnion A-C, Matera A, Tavernari D, Campiche O, Paolicelli RC, Zanou N, Kayser B, Gnaiger E, Place N (2024) Functional hypoxia reduces mitochondrial calcium uptake. Redox Biol 71:103037. https://doi.org/10.1016/j.redox.2024.103037 | LEAK OXPHOS ET | N S NS ROX | Intact organism Isolated mitochondria Intact cells | Human Mouse | Heart Skeletal muscle |
| Meszaros 2024 Transpl Int | 2024 | Meszaros AT, Weissenbacher A, Schartner M, Egelseer-Bruendl T, Hermann M, Unterweger J, Mittelberger C, Reyer BA, Hofmann J, Zelger BG, Hautz T, Resch T, Margreiter C, Maglione M, Komlódi T, Ulmer H, Cardini B, Troppmair J, Öfner D, Gnaiger E, Schneeberger S, Oberhuber R (2024) The predictive value of graft viability and bioenergetics testing towards the outcome in liver transplantation. Transpl Int 37:12380. https://doi.org/10.3389/ti.2024.12380 | LEAK OXPHOS ET | N S NS F ROX | Homogenate | Human | Liver |
| Hu 2024 Front Endocrinol (Lausanne) | 2024 | Hu Y, Fang B, Tian X, Wang H, Tian X, Yu F, Li T, Yang Z, Shi R (2024) Passive exercise is an effective alternative to HRT for restoring OVX induced mitochondrial dysfunction in skeletal muscle. Front Endocrinol (Lausanne) 15:1356312. https://doi.org/10.3389/fendo.2024.1356312 | LEAK OXPHOS | N S CIV NS ROX | Permeabilized tissue | Mouse | Skeletal muscle |
| Al-Sabri 2024 Sci Rep | 2024 | Al-Sabri MH, Ammar N, Korzh S, Alsehli AM, Hosseini K, Fredriksson R, Mwinyi J, Williams MJ, Boukhatmi H, Schiöth HB (2024) Fluvastatin-induced myofibrillar damage is associated with elevated ROS, and impaired fatty acid oxidation, and is preceded by mitochondrial morphological changes. https://doi.org/10.1038/s41598-024-53446-w | LEAK OXPHOS ET | F N S Gp NS ROX | Permeabilized tissue | Drosophila | Skeletal muscle |
| Brunetta 2024 MitoFit | 2024 | Brunetta HS, Holloway GP (2024) Methodological considerations for the determination of mitochondrial ADP sensitivity in skeletal muscle. MitoFit Preprints 2024. 1. https://doi.org/10.26124/mitofit:2024-0001 | N NS | Permeabilized tissue | Mouse | Skeletal muscle | |
| Fitzgerald 2024 J Cachexia Sarcopenia Muscle | 2024 | Fitzgerald LF, Lackey J, Moussa A, Shah SV, Castellanos AM, Khan S, Schonk M, Thome T, Salyers ZR, Jakkidi N, Kim K, Yang Q, Hepple RT, Ryan TE (2024) Chronic aryl hydrocarbon receptor activity impairs muscle mitochondrial function with tobacco smoking. https://doi.org/10.1002/jcsm.13439 | LEAK OXPHOS | N CIV NS ROX | Permeabilized tissue Isolated mitochondria | Mouse | Skeletal muscle |
| Qiao 2024 J Sport Health Sci | 2024 | Qiao YS, Blackwell TL, Cawthon PM, Coen PM, Cummings SR, Distefano G, Farsijani S, Forman DE, Goodpaster BH, Kritchevsky SB, Mau T, Toledo FGS, Newman AB, Glynn NW (2024) Associations of accelerometry-measured and self-reported physical activity and sedentary behavior with skeletal muscle energetics: The Study of Muscle, Mobility and Aging (SOMMA). https://doi.org/10.1016/j.jshs.2024.02.001 | LEAK OXPHOS | N NS | Permeabilized tissue | Human | Skeletal muscle |
| Balmaceda 2024 Biochim Biophys Acta Mol Basis Dis | 2024 | Balmaceda V, Komlodi T, Szibor M, Gnaiger E, Moore AL, Fernandez-Vizarra E, Viscomi C (2024) The striking differences in the bioenergetics of brain and liver mitochondria are enhanced in mitochondrial disease. Biochim Biophys Acta Mol Basis Dis 1870:167033. https://doi.org/10.1016/j.bbadis.2024.167033 | LEAK OXPHOS ET | N S NS | Isolated mitochondria | Mouse | Nervous system Liver |
| Patil 2024 J Exp Biol | 2024 | Patil YN, Gnaiger E, Landry AP, Leno ZJ, Hand SC (2024) OXPHOS capacity is diminished and the phosphorylation system inhibited during diapause in an extremophile, embryos of Artemia franciscana. J Exp Biol 227:jeb.245828. https://doi.org/10.1242/jeb.245828 | LEAK OXPHOS ET | F N S NS | Homogenate Isolated mitochondria | Artemia | |
| Visker 2024 Exp Physiol | 2024 | Visker JR, Leszczynski EC, Wellette-Hunsucker AG, McPeek AC, Quinn MA, Kim SH, Bazil JN, Ferguson DP (2024) Postnatal growth restriction alters myocardial mitochondrial energetics in mice. https://doi.org/10.1113/ep091304 | LEAK OXPHOS | F N S NS | Isolated mitochondria | Mouse | Heart |
| Dong 2024 Nat Commun | 2024 | Dong J, Chen L, Ye F, Tang J, Liu B, Lin J, Zhou PH, Lu B, Wu M, Lu JH, He JJ, Engelender S, Meng Q, Song Z, He H (2024) Mic19 depletion impairs endoplasmic reticulum-mitochondrial contacts and mitochondrial lipid metabolism and triggers liver disease. https://doi.org/10.1038/s41467-023-44057-6 | LEAK OXPHOS ET | N S CIV NS | Homogenate | Mouse | Liver |
| Leo 2024 MitoFit | 2024 | Leo E, Rychtarova L, Garcia-Souza LF, Åsander Frostner E, Elmér E, Gnaiger E (2024) High-resolution respirometry in a small-volume chamber. MitoFit Preprints 2024.4.v2. https://doi.org/10.26124/mitofit:2024-0004.v2 | ET LEAK ROUTINE OXPHOS | F N S Gp CIV NS Other combinations ROX | Permeabilized cells Homogenate Isolated mitochondria Intact cells | Human Mouse | Heart Nervous system Blood cells HUVEC Platelet |
| Balnis 2024 Sci Adv | 2024 | Balnis J, Tufts A, Jackson EL, Drake LA, Singer DV, Lacomis D, Lee CG, Elias JA, Doles JD, Maher LJ 3rd, Jen A, Coon JJ, Jourd'heuil D, Singer HA, Vincent CE, Jaitovich A (2024) Succinate dehydrogenase-complex II regulates skeletal muscle cellular respiration and contractility but not muscle mass in genetically induced pulmonary emphysema. Sci Adv [Epub ahead of print]. https://doi.org/10.1126/sciadv.ado8549 | ET LEAK OXPHOS | N S NS | Permeabilized tissue | Mouse | Skeletal muscle |
| Jardon 2024 Gut Microbes | 2024 | Jardon KM, Goossens GH, Most J, Galazzo G, Venema K, Penders J, Blaak EE (2024) Examination of sex-specific interactions between gut microbiota and host metabolism after 12-week combined polyphenol supplementation in individuals with overweight or obesity. Gut Microbes 16:2392875. https://doi.org/10.1080/19490976.2024.2392875 | ET LEAK OXPHOS | N NS | Permeabilized tissue | Human | Skeletal muscle |
| Kolb 2024 Biochemistry | 2024 | Kolb AJ, Corridon P, Ullah M, Pfaffenberger ZJ, Xu WM, Winfree S, Sandoval RH, Hato T, Witzmann FA, Mohallem R, Franco J, Aryal UK, Atkinson SJ, Basile DP, Bacallao RL (2024) Sulfotransferase 1C2 increases mitochondrial respiration by converting mitochondrial membrane cholesterol to cholesterol sulfate. Biochemistry [Epub ahead of print]. https://doi.org/10.1021/acs.biochem.3c00344 | LEAK OXPHOS | N S NS | Isolated mitochondria | Rat | Kidney |
| Liu 2024 Cell Death Dis | 2024 | Liu JC, Zhao XY, Wu ML, Shi YF, Huang ZP, Fang LP, Zhu C, Peng X, Shi ZL, Lan LJ, Ji WL, Luo L, Feng L, Zhang ZL, Xu DE, Li S, Qin ZH, Sun YY, Schachner M, Ma QH (2024) GPR50 regulates neuronal development as a mitophagy receptor. Cell Death Dis 15:591. https://doi.org/10.1038/s41419-024-06978-y | ET LEAK OXPHOS | N S CIV NS ROX | Homogenate | Mouse | Nervous system |
| Zhang 2024 Cell Metab | 2024 | Zhang Y, Higgins CB, Tica S, Adams JA, Sun J, Kelly SC, Zong X, Dietzen DJ, Pietka T, Ballentine SJ, Shriver L, Patti G, Cao Y, DeBosch BJ (2024) Hierarchical tricarboxylic acid cycle regulation by hepatocyte arginase 2 links the urea cycle to oxidative metabolism. Cell Metab [Epub ahead of print]. https://doi.org/10.1016/j.cmet.2024.07.007 | ET LEAK OXPHOS | N NS | Mouse | Liver | |
| Doerrier 2024 Free Radic Biol Med | 2024 | Doerrier C, Gama-Perez P, Pesta D, Distefano G, Soendergaard SD, Maise Chroeis K, Gonzalez-Franquesa A, Goodpaster BH, Prats C, Sales-Pardo M, Guimera R, Coen PM, Gnaiger E, Larsen S, Garcia-Roves PM (2024) Harmonization of experimental procedures to assess mitochondrial respiration in human permeabilized skeletal muscle fibers. Free Radic Biol Med 223:384-97. https://doi.org/10.1016/j.freeradbiomed.2024.07.039 | ET LEAK OXPHOS | N S NS ROX | Permeabilized tissue | Human | Skeletal muscle |
| Magri 2024 Cell Death Discov | 2024 | Magrì A, Lipari CLR, Caccamo A, Battiato G, Conti Nibali S, De Pinto V, Guarino F, Messina A (2024) AAV-mediated upregulation of VDAC1 rescues the mitochondrial respiration and sirtuins expression in a SOD1 mouse model of inherited ALS. Cell Death Discov 10:178. https://doi.org/10.1038/s41420-024-01949-w | ET LEAK OXPHOS | N S NS ROX | Homogenate | Mouse | Nervous system |
| Wang 2024 J Biomed Sci | 2024 | Wang V, Tseng KY, Kuo TT, Huang EY, Lan KL, Chen ZR, Ma KH, Greig NH, Jung J, Choi HI, Olson L, Hoffer BJ, Chen YH (2024) Attenuating mitochondrial dysfunction and morphological disruption with PT320 delays dopamine degeneration in MitoPark mice. J Biomed Sci 31:38. https://doi.org/10.1186/s12929-024-01025-6 | ET LEAK OXPHOS | N S CIV NS ROX | Homogenate | Mouse | Nervous system |
| Artman 2024 J Equine Vet Sci | 2024 | Artman JL, Wesolowski LT, Semanchik PL, Isles JK, Norton SA, White-Springer SH (2024) Local and systemic responses to repeated gluteal muscle microbiopsies in mature sedentary horses. J Equine Vet Sci 136:105070. https://doi.org/10.1016/j.jevs.2024.105070 | ET LEAK OXPHOS | N S NS ROX | Permeabilized tissue | Horse | Skeletal muscle |
| Alanova 2024 Acta Physiol (Oxf) | 2024 | Alanova P, Alan L, Opletalova B, Bohuslavova R, Abaffy P, Matejkova K, Holzerova K, Benak D, Kaludercic N, Menabo R, Di Lisa F, Ostadal B, Kolar F, Pavlinkova G (2024) HIF-1α limits myocardial infarction by promoting mitophagy in mouse hearts adapted to chronic hypoxia. Acta Physiol (Oxf) [Epub ahead of print]. https://doi.org/10.1111/apha.14202 | ET LEAK OXPHOS | F N S CIV NS | Isolated mitochondria | Mouse | Heart |
| Holwerda 2024 J Cachexia Sarcopenia Muscle | 2024 | Holwerda AM, Dirks ML, Barbeau PA, Goessens J, Gijsen A, van Loon LJC, Holloway GP (2024) Mitochondrial bioenergetics are not associated with myofibrillar protein synthesis rates. J Cachexia Sarcopenia Muscle [Epub ahead of print]. https://doi.org/10.1002/jcsm.13532 | LEAK OXPHOS | N S NS | Permeabilized tissue | Human Mouse | Skeletal muscle |
| Zhao 2024 J Adv Res | 2024 | Zhao Y, Lu Z, Zhang H, Wang L, Sun F, Li Q, Cao T, Wang B, Ma H, You M, Zhou Q, Wei X, Li L, Liao Y, Yan Z, Liu D, Gao P, Zhu Z (2024) Sodium-glucose exchanger 2 inhibitor canagliflozin promotes mitochondrial metabolism and alleviates salt-induced cardiac hypertrophy via preserving SIRT3 expression. J Adv Res [Epub ahead of print]. https://doi.org/10.1016/j.jare.2024.04.030 | ET LEAK OXPHOS | F N S NS ROX | Isolated mitochondria | Mouse | Heart |
| Wilburn 2024 Sci Rep | 2024 | Wilburn D, Miserlis D, Fletcher E, Papoutsi E, Ismaeel A, Bradley C, Ring A, Wilkinson T, Smith RS, Ferrer L, Haynatzki G, Monteleone P, Banerjee S, Brisbois E, Bohannon WT, Koutakis P (2024) Skeletal muscle desmin alterations following revascularization in peripheral artery disease claudicants. Sci Rep 14:12609. https://doi.org/10.1038/s41598-024-63626-3 | LEAK OXPHOS | N S DQ CIV NS ROX | Permeabilized tissue | Human | Skeletal muscle |
| Morishita 2024 Biol Pharm Bull | 2024 | Morishita R, Onishi A, Oya M, Karashima H, Mori M, Kawatani Y, Kamei N, Takeda-Morishita M (2024) Effect of orally ingested water containing H2-filled ultrafine bubbles (UFBs) on ethanol-induced oxidative stress in rats. Biol Pharm Bull 47:1106-12. https://doi.org/10.1248/bpb.b24-00034 | ET LEAK OXPHOS | N S NS ROX | Homogenate | Rat | Liver |
| Wang 2024 Adv Sci (Weinh) | 2024 | Wang H, Stevens T, Lu J, Roberts A, Van't Land C, Muzumdar R, Gong Z, Vockley J, Prochownik EV (2024) Body-wide inactivation of the Myc-like Mlx transcription factor network accelerates aging and increases the lifetime cancer incidence. Adv Sci (Weinh) [Epub ahead of print]. https://doi.org/10.1002/advs.202401593 | LEAK OXPHOS | F N S NS | Isolated mitochondria | Mouse | Fat Skeletal muscle Liver |
| Noerregaard 2024 J Physiol | 2024 | Noerregaard LB, Hansen CC, Wickham KA, Moeller S, Olsen K, Ehlers T, Bangsbo J, Hellsten Y (2024) Exercise training alters skeletal muscle microvascular endothelial cell properties in recent postmenopausal females. J Physiol [Epub ahead of print]. https://doi.org/10.1113/jp286269 | LEAK OXPHOS ROUTINE | N S NS | Permeabilized cells Intact cells | Human | Skeletal muscle Endothelial;epithelial;mesothelial cell |
| Westerlund 2024 Heliyon | 2024 | Westerlund E, Marelsson SE, Karlsson M, Sjövall F, Chamkha I, Åsander Frostner E, Lundgren J, Fellman V, Eklund EA, Steding-Ehrenborg K, Darin N, Paul G, Hansson MJ, Ehinger JK, Elmér E (2024) Correlation of mitochondrial respiration in platelets, peripheral blood mononuclear cells and muscle fibers. Heliyon 10:e26745. https://doi.org/10.1016/j.heliyon.2024.e26745 | ET LEAK ROUTINE OXPHOS | N S CIV NS ROX | Permeabilized cells Permeabilized tissue Intact cells | Human | Skeletal muscle Blood cells Platelet |
| Li 2024 Cell Res | 2024 | Li M, Wang Y, Wei X, Cai WF, Wu J, Zhu M, Wang Y, Liu YH, Xiong J, Qu Q, Chen Y, Tian X, Yao L, Xie R, Li X, Chen S, Huang X, Zhang C, Xie C, Wu Y, Xu Z, Zhang B, Jiang B, Wang ZC, Li Q, Li G, Lin SY, Yu L, Piao HL, Deng X, Han J, Zhang CS, Lin SC (2024) AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine. Cell Res [Epub ahead of print]. https://doi.org/10.1038/s41422-024-00985-6 | ET LEAK OXPHOS | N NS | Permeabilized tissue | Mouse | Skeletal muscle |
| Dulac 2024 J Physiol | 2024 | Dulac M, Hajj-Boutros G, Sonjak V, Faust A, Hussain SNA, Chevalier S, Dionne IJ, Morais JA, Gouspillou G (2024) A multimodal exercise countermeasure prevents the negative impact of head-down tilt bed rest on muscle volume and mitochondrial health in older adults. J Physiol [Epub ahead of print]. https://doi.org/10.1113/jp285897 | LEAK OXPHOS | F N NS ROX | Permeabilized tissue | Human | Skeletal muscle |
| Brunetta 2024 BEC | 2024 | Brunetta HS, Holloway GP (2024) Methodological considerations for the determination of mitochondrial ADP sensitivity in skeletal muscle. Bioenerg Commun 2024.4. https://doi.org/10.26124/bec:2024-0004 | N NS | Permeabilized tissue | Mouse | Skeletal muscle | |
| Buescher 2024 Acta Physiol (Oxf) | 2024 | Buescher FM, Schmitz MT, Frett T, Kramme J, de Boni L, Elmenhorst EM, Mulder E, Moestl S, Heusser K, Frings-Meuthen P, Jordan J, Rittweger J, Pesta D (2024) Effects of 30 days bed rest and exercise countermeasures on PBMC bioenergetics. Acta Physiol (Oxf) 240(3):e14102. https://doi.org/10.1111/apha.14102 | ET LEAK ROUTINE OXPHOS | N NS | Permeabilized cells Intact cells | Human | Blood cells |
| Szulik 2023 Basic Res Cardiol | 2023 | Szulik MW, Valdez S, Walsh M, Davis K, Bia R, Horiuchi E, O'Very S, Laxman AK, Sandaklie-Nicolova L, Eberhardt DR, Durrant JR, Sheikh H, Hickenlooper S, Creed M, Brady C, Miller M, Wang L, Garcia-Llana J, Tracy C, Drakos SG, Funai K, Chaudhuri D, Boudina S, Franklin S (2023) SMYD1a protects the heart from ischemic injury by regulating OPA1-mediated cristae remodeling and supercomplex formation. https://doi.org/10.1007/s00395-023-00991-6 | LEAK OXPHOS ET | N NS | Isolated mitochondria | Mouse | Heart |
| Bellar 2023 Clin Transl Med | 2023 | Bellar A, Welch N, Dasarathy J, Attaway A, Musich R, Kumar A, Sekar J, Mishra S, Sandlers Y, Streem D, Nagy LE, Dasarathy S (2023) Peripheral blood mononuclear cell mitochondrial dysfunction in acute alcohol-associated hepatitis. https://doi.org/10.1002/ctm2.1276 | LEAK ROUTINE OXPHOS ET | N S CIV NS ROX | Permeabilized cells Intact cells | Human | Blood cells |
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| Gonzalez-Franquesa 2022 Redox Biol | 2022 | Gonzalez-Franquesa A, Gama-Perez P, Kulis M, Szczepanowska K, Dahdah N, Moreno-Gomez S, Latorre-Pellicer A, Fernández-Ruiz R, Aguilar-Mogas A, Hoffman A, Monelli E, Samino S, Miró-Blanch J, Oemer G, Duran X, Sanchez-Rebordelo E, Schneeberger M, Obach M, Montane J, Castellano G, Chapaprieta V, Sun W, Navarro L, Prieto I, Castaño C, Novials A, Gomis R, Monsalve M, Claret M, Graupera M, Soria G, Wolfrum C, Vendrell J, Fernández-Veledo S, Enríquez JA, Carracedo A, Perales JC, Nogueiras R, Herrero L, Trifunovic A, Keller MA, Yanes O, Sales-Pardo M, Guimerà R, Blüher M, Martín-Subero JI, Garcia-Roves PM (2022) Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue. https://doi.org/10.1016/j.redox.2022.102353 | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue Homogenate | Mouse | Skeletal muscle Nervous system Liver Fat |
| Meszaros 2022 EBioMedicine | 2022 | Meszaros AT, Hofmann J, Buch ML, Cardini B, Dunzendorfer-Matt T, Nardin F, Blumer MJ, Fodor M, Hermann M, Zelger B, Otarashvili G, Schartner M, Weissenbacher A, Oberhuber R, Resch T, Troppmair J, Öfner D, Zoller H, Tilg H, Gnaiger E, Hautz T, Schneeberger S (2022) Mitochondrial respiration during normothermic liver machine perfusion predicts clinical outcome. https://doi.org/10.1016/j.ebiom.2022.104311 | OXPHOS ET LEAK | F N S NS ROX | Homogenate | Human | Liver |
| Pallag 2022 Int J Mol Sci | 2022 | Pallag G, Nazarian S, Ravasz D, Bui D, Komlódi T, Doerrier C, Gnaiger E, Seyfried TN, Chinopoulos C (2022) Proline oxidation supports mitochondrial ATP production when Complex I is inhibited. https://doi.org/10.3390/ijms23095111 | LEAK OXPHOS ET | N S Gp CIV NS Other combinations ROX | Isolated mitochondria | Mouse | Liver Kidney |
| Mandic 2022 J Comp Physiol B | 2022 | Mandic M, Frazier AJ, Naslund AW, Todgham AE (2022) A comparative and ontogenetic examination of mitochondrial function in antarctic notothenioid species. https://doi.org/10.1007/s00360-022-01461-6 | LEAK OXPHOS ET | N S CIV NS ROX | Permeabilized tissue | Fishes | Heart |
| Paulus 2022 Basic Res Cardiol | 2022 | Paulus MG, Renner K, Nickel AG, Brochhausen C, Limm K, Zügner E, Baier MJ, Pabel S, Wallner S, Birner C, Luchner A, Magnes C, Oefner PJ, Stark KJ, Wagner S, Maack C, Maier LS, Streckfuss-Bömeke K, Sossalla S, Dietl A (2022) Tachycardiomyopathy entails a dysfunctional pattern of interrelated mitochondrial functions. https://doi.org/10.1007/s00395-022-00949-0 | OXPHOS ET | NS F ROX | Permeabilized tissue Isolated mitochondria | Rabbit | Heart |
| Li 2022 Mol Med | 2022 | Li X, Zhou X, Liu X, Li X, Jiang X, Shi B, Wang S (2022) Spermidine protects against acute kidney injury by modulating macrophage NLRP3 inflammasome activation and mitochondrial respiration in an eIF5A hypusination-related pathway. https://doi.org/10.1186/s10020-022-00533-1 | LEAK OXPHOS ET | N S NS ROX | Permeabilized cells | Human | Blood cells |
| Gvozdjakova 2022 Environ Sci Pollut Res Int | 2022 | Gvozdjáková A, Sumbalová Z, Kucharská J, Rausová Z, Kovalčíková E, Takácsová T, Navas P, López-Lluch G, Mojto V, Palacka P (2022) Mountain spa rehabilitation improved health of patients with post-COVID-19 syndrome: pilot study. https://doi.org/10.1007/s11356-022-22949-2 | LEAK ROUTINE OXPHOS ET | N NS | Permeabilized cells Intact cells | Human | Platelet |
| Chinas 2022 Metabolites | 2022 | Chiñas Merlin A, Gonzalez K, Mockler S, Perez Y, Jia UA, Chicco AJ, Ullevig SL, Chung E (2022) Switching to a standard chow diet at weaning improves the effects of maternal and postnatal high-fat and high-sucrose diet on cardiometabolic health in adult male mouse offspring. https://doi.org/10.3390/metabo12060563 | LEAK OXPHOS | F N NS | Isolated mitochondria | Mouse | Heart |
| Vandenberg 2022 Am J Physiol Cell Physiol | 2022 | Vandenberg GG, Thotakura A, Scott AL (2022) Mitochondrial bioenergetics of astrocytes in Fragile X syndrome: new perspectives on culture conditions and sex effects. Am J Physiol Cell Physiol 322:C125-35. https://doi.org/10.1152/ajpcell.00130.2021 | LEAK OXPHOS | N S CIV NS ROX | Permeabilized cells | Mouse | Nervous system |
| Cano-Sanchez 2022 PLoS Negl Trop Dis | 2022 | Cano-Sanchez M, Ben-Hassen K, Louis OP, Dantin F, Gueye P, Roques F, Mehdaoui H, Resiere D, Neviere R (2022) Bothrops lanceolatus snake venom impairs mitochondrial respiration and induces DNA release in human heart preparation. https://doi.org/10.1371/journal.pntd.0010523 | LEAK OXPHOS ET | N S CIV NS ROX | Permeabilized tissue | Human | Heart |
| Sarabhai 2022 Diabetologia | 2022 | Sarabhai T, Mastrototaro L, Kahl S, Bönhof GJ, Jonuscheit M, Bobrov P, Katsuyama H, Guthoff R, Wolkersdorfer M, Herder C, Meuth SG, Dreyer S, Roden M (2022) Hyperbaric oxygen rapidly improves tissue-specific insulin sensitivity and mitochondrial capacity in humans with type 2 diabetes: a randomised placebo-controlled crossover trial. https://doi.org/10.1007/s00125-022-05797-0 | LEAK OXPHOS ET | N NS ROX | Permeabilized tissue | Human | Skeletal muscle Fat |
| Cherix 2022 Mol Psychiatry | 2022 | Cherix A, Poitry-Yamate C, Lanz B, Zanoletti O, Grosse J, Sandi C, Gruetter R, Cardinaux JR (2022) Deletion of Crtc1 leads to hippocampal neuroenergetic impairments associated with depressive-like behavior. https://doi.org/10.1038/s41380-022-01791-5 | LEAK OXPHOS ET | N S NS ROX | Homogenate | Mouse | Nervous system |
| Xu 2022 Sci Adv | 2022 | Xu H, Ahn B, Van Remmen H (2022) Impact of aging and oxidative stress on specific components of excitation contraction coupling in regulating force generation. https://doi.org/10.1126/sciadv.add7377 | LEAK OXPHOS | N S CIV NS ROX | Permeabilized tissue | Mouse | Skeletal muscle |
| Zhang 2022 Int J Mol Sci | 2022 | Zhang A, Gupte AA, Chatterjee S, Li S, Ayala AG, Miles BJ, Hamilton DJ (2022) Enhanced succinate oxidation with mitochondrial complex II reactive oxygen species generation in human prostate cancer. https://doi.org/10.3390/ijms232012168 | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue | Human | Genital |
| Fischer 2022 Metabolites | 2022 | Fischer C, Valente de Souza L, Komlódi T, Garcia-Souza LF, Volani C, Tymoszuk P, Demetz E, Seifert M, Auer K, Hilbe R, Brigo N, Petzer V, Asshoff M, Gnaiger E, Weiss G (2022) Mitochondrial respiration in response to iron deficiency anemia. Comparison of peripheral blood mononuclear cells and liver. https://doi.org/10.3390/metabo12030270 | LEAK ROUTINE OXPHOS ET | N S NS Other combinations ROX | Permeabilized cells Homogenate | Rat | Liver Blood cells |
| Qvit 2022 Pharmaceuticals (Basel) | 2022 | Qvit N, Lin AJ, Elezaby A, Ostberg NP, Campos JC, Ferreira JCB, Mochly-Rosen D (2022) A selective inhibitor of cardiac troponin I phosphorylation by delta protein kinase C (δPKC) as a treatment for ischemia-reperfusion injury. https://doi.org/10.3390/ph15030271 | LEAK OXPHOS | NS | Isolated mitochondria | Rat | Heart |
| De Jong 2022 Nutrients | 2022 | De Jong NP, Rudolph MC, Jackman MR, Sharp RR, Jones K, Houck J, Pan Z, Reusch JEB, MacLean PS, Bessesen DH, Bergouignan A (2022) Short-term adaptations in skeletal muscle mitochondrial oxidative capacity and metabolic pathways to breaking up sedentary behaviors in overweight or obese adults. https://doi.org/10.3390/nu14030454 | LEAK OXPHOS ET | F N S NS ROX | Permeabilized tissue | Human | Skeletal muscle |
| Zhang 2022 Mol Med Rep | 2022 | Zhang J, Sun B, Yang J, Chen Z, Li Z, Zhang N, Li H, Shen L (2022) Comparison of the effect of rotenone and 1‑methyl‑4‑phenyl‑1,2,3,6‑tetrahydropyridine on inducing chronic Parkinson's disease in mouse models. https://doi.org/10.3892/mmr.2022.12607 | LEAK OXPHOS ET | N NS | Isolated mitochondria | Mouse | Nervous system |
| Sumbalova 2022 Front Mol Biosci | 2022 | Sumbalová Z, Kucharská J, Rausová Z, Palacka P, Kovalčíková E, Takácsová T, Mojto V, Navas P, Lopéz-Lluch G, Gvozdjáková A (2022) Reduced platelet mitochondrial respiration and oxidative phosphorylation in patients with post COVID-19 syndrome are regenerated after spa rehabilitation and targeted ubiquinol therapy. https://doi.org/10.3389/fmolb.2022.1016352 | LEAK ROUTINE OXPHOS ET | N NS | Permeabilized cells Intact cells | Human | Platelet |
| Chicco 2022 MitoFit | 2022 | Chicco AJ, Zilhaver PT, Whitcomb LA, Fresa KJ, Izon CS, Gonzalez-Franquesa A, Izon CS, Dometita C, Irving BA, Garcia-Roves PM (2022) Resolving the Rotenone Paradox: elucidating the complexity of multi-substrate respirometry protocols. https://doi.org/10.26124/mitofit:2022-0017 | N S NS | Isolated mitochondria | |||
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| Englund 2022 Mol Metab | 2022 | Englund DA, Jolliffe A, Aversa Z, Zhang X, Sturmlechner I, Sakamoto AE, Zeidler JD, Warner GM, McNinch C, White TA, Chini EN, Baker DJ, van Deursen JM, LeBrasseur NK (2022) p21 induces a senescence program and skeletal muscle dysfunction. https://doi.org/10.1016/j.molmet.2022.101652 | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue | Mouse | Skeletal muscle |
| Galambo 2022 Curr Res Physiol | 2022 | Galambo D, Bergdahl A (2022) Physiological levels of cardiolipin acutely affect mitochondrial respiration in vascular smooth muscle cells. https://doi.org/10.1016/j.crphys.2022.100097 | LEAK OXPHOS | F N NS ROX | Permeabilized cells | Mouse | Other cell lines |
| Ahn 2022 Aging Cell | 2022 | Ahn B, Ranjit R, Kneis P, Xu H, Piekarz KM, Freeman WM, Kinter M, Richardson A, Ran Q, Brooks SV, Van Remmen H (2022) Scavenging mitochondrial hydrogen peroxide by peroxiredoxin 3 overexpression attenuates contractile dysfunction and muscle atrophy in a murine model of accelerated sarcopenia. Aging Cell 21:e13569. | LEAK OXPHOS | N S NS ROX | Isolated mitochondria | Mouse | Skeletal muscle |
| Alexander 2022 Cardiovasc Drugs Ther | 2022 | Alexander ED, Aldridge JL, Burleson TS, Frasier CR (2022) Teriflunomide treatment exacerbates cardiac ischemia reperfusion injury in isolated rat hearts. https://doi.org/10.1007/s10557-022-07341-z | ET LEAK OXPHOS | N NS | Isolated mitochondria | Rat | Heart |
| Molinie 2022 Biochim Biophys Acta Bioenerg | 2022 | Molinié T, Cougouilles E, David C, Cahoreau E, Portais JC, Mourier A (2022) MDH2 produced OAA is a metabolic switch rewiring the fuelling of respiratory chain and TCA cycle. Biochim Biophys Acta Bioenerg 1863:148532. | LEAK OXPHOS ET | N S NS ROX | Isolated mitochondria | Mouse | Heart Liver |
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| Lemminger 2022 Antioxidants (Basel) | 2022 | Lemminger AK, Fiorenza M, Eibye K, Bangsbo J, Hostrup M (2022) High-intensity exercise training alters the effect of N-acetylcysteine on exercise-related muscle ionic shifts in men. https://doi.org/10.3390/antiox12010053 | LEAK OXPHOS ET | F N S NS ROX | Permeabilized tissue | Human | Skeletal muscle |
| Spielmann 2022 Mamm Genome | 2022 | Spielmann N, Schenkl C, Komlódi T, da Silva-Buttkus P, Heyne E, Rohde J, Amarie OV, Rathkolb B, Gnaiger E, Doenst T, Fuchs H, Gailus-Durner V, de Angelis MH, Szibor M (2022) Knockout of the Complex III subunit Uqcrh causes bioenergetic impairment and cardiac contractile dysfunction. Mamm Genome 10.1007/s00335-022-09973-w | LEAK OXPHOS ET | N S NS ROX | Intact organism Isolated mitochondria | Mouse | Heart |
| De Goede 2022 FASEB J | 2022 | de Goede P, Wüst RCI, Schomakers BV, Denis S, Vaz FM, Pras-Raves ML, van Weeghel M, Yi CX, Kalsbeek A, Houtkooper RH (2022) Time-restricted feeding during the inactive phase abolishes the daily rhythm in mitochondrial respiration in rat skeletal muscle. FASEB J 36:e22133. | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue | Rat | Skeletal muscle |
| Schober 2022 Hum Mol Genet | 2022 | Schober FA, Tang JX, Sergeant K, Moedas MF, Zierz CM, Moore D, Smith C, Lewis D, Guha N, Hopton S, Falkous G, Lam A, Pyle A, Poulton J, Gorman GS, Taylor RW, Freyer C, Wredenberg A (2022) Pathogenic SLC25A26 variants impair SAH transport activity causing mitochondrial disease. https://doi.org/10.1093/hmg/ddac002 | LEAK OXPHOS | N S CIV NS ROX | Permeabilized cells Intact cells | Mouse Drosophila | Fibroblast |
| Lehto 2022 Neurochem Res | 2022 | Lehto A, Koch K, Barnstorf-Brandes J, Viel C, Fuchs M, Klein J (2022) ß-Hydroxybutyrate improves mitochondrial function after transient ischemia in the mouse. https://doi.org/10.1007/s11064-022-03637-6 | LEAK OXPHOS ET | N S CIV NS ROX | Isolated mitochondria | Mouse | Nervous system |
| Banerjee 2022 FEBS J | 2022 | Banerjee R, Purhonen J, Kallijärvi J (2022) The mitochondrial coenzyme Q junction and Complex III: biochemistry and pathophysiology. FEBS J 289:6936-58. https://doi.org/10.1111/febs.16164 | NS | ||||
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| Soares 2022 Geroscience | 2022 | Soares RN, Ramirez-Perez FI, Cabral-Amador FJ, Morales-Quinones M, Foote CA, Ghiarone T, Sharma N, Power G, Smith JA, Rector RS, Martinez-Lemus LA, Padilla J, Manrique-Acevedo C (2022) SGLT2 inhibition attenuates arterial dysfunction and decreases vascular F-actin content and expression of proteins associated with oxidative stress in aged mice. https://doi.org/10.1007/s11357-022-00563-x | LEAK OXPHOS ET | N S NS ROX | Permeabilized cells | Mouse | Endothelial;epithelial;mesothelial cell |
| Petry 2022 Antioxidants (Basel) | 2022 | Petry SF, Römer A, Rawat D, Brunner L, Lerch N, Zhou M, Grewal R, Sharifpanah F, Sauer H, Eckert GP, Linn T (2022) Loss and recovery of glutaredoxin 5 is inducible by diet in a murine model of diabesity and mediated by free fatty acids in vitro. https://doi.org/10.3390/antiox11040788 | LEAK OXPHOS ET | N S CIV NS ROX | Permeabilized cells | Mouse | Islet cell;pancreas;thymus |
| Hansen 2022 Magn Reson Med | 2022 | Hansen K, Hansen ESS, Jespersen NRV, Bøtker HE, Pedersen M, Wang T, Laustsen C (2022) Hyperpolarized 13C MRI reveals large changes in pyruvate metabolism during digestion in snakes. https://doi.org/10.1002/mrm.29239 | LEAK OXPHOS ET | N S NS ROX | Isolated mitochondria | Reptiles | Liver |
| Bina 2022 Mol Cell Biochem | 2022 | Bînă AM, Aburel OM, Avram VF, Lelcu T, Lința AV, Chiriac DV, Mocanu AG, Bernad E, Borza C, Craina ML, Popa ZL, Muntean DM, Crețu OM (2022) Impairment of mitochondrial respiration in platelets and placentas: a pilot study in preeclamptic pregnancies. https://doi.org/10.1007/s11010-022-04415-2 | LEAK ROUTINE OXPHOS ET | N S NS ROX | Permeabilized cells Isolated mitochondria Intact cells | Human | Genital Platelet |
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| Starr 2022 Curr Res Physiol | 2022 | Starr VJ, Dzialowski EM (2022) Developing chicken cardiac muscle mitochondria are resistant to variations in incubation oxygen levels. https://doi.org/10.1016/j.crphys.2022.03.001 | LEAK OXPHOS | N S CIV NS ROX | Permeabilized tissue | Chicken | Heart |
| Loughland 2022 J Exp Biol | 2022 | Loughland I, Lau GY, Jolly J, Seebacher F (2022) Rates of warming impact oxidative stress in zebrafish (Danio rerio). | LEAK OXPHOS ET | N NS | Isolated mitochondria | Zebrafish | Skeletal muscle |
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| Hadanny 2022 Sports Med Open | 2022 | Hadanny A, Hachmo Y, Rozali D, Catalogna M, Yaakobi E, Sova M, Gattegno H, Abu Hamed R, Lang E, Polak N, Friedman M, Finci S, Zemel Y, Bechor Y, Gal N, Efrati S (2022) Effects of hyperbaric oxygen therapy on mitochondrial respiration and physical performance in middle-aged athletes: a blinded, randomized controlled trial. | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue | Human | Skeletal muscle |
| Chojnacka 2022 Mol Biol Cell | 2022 | Chojnacka KJ, Elancheliyan P, Mussulini BHM, Mohanraj K, Callegari S, Gosk A, Banach T, Góral T, Szczepanowska K, Rehling P, Serwa RA, Chacinska A (2022) Ovarian carcinoma immunoreactive antigen-like protein 2 (OCIAD2) is a novel complex III-specific assembly factor in mitochondria. https://doi.org/10.1091/mbc.e21-03-0143 | LEAK ROUTINE OXPHOS ET | F N S Gp CIV NS ROX | Permeabilized cells Intact cells | Human | HEK |
| Crislip 2022 Biomolecules | 2022 | Crislip GR, Wohlgemuth SE, Wolff CA, Gutierrez-Monreal MA, Douglas CM, Ebrahimi E, Cheng KY, Masten SH, Barral D, Bryant AJ, Esser KA, Gumz ML (2022) Apparent absence of BMAL1-dependent skeletal muscle-kidney cross talk in mice. https://doi.org/10.3390/biom12020261 | LEAK OXPHOS ET | N S CIV NS ROX | Isolated mitochondria | Mouse | Kidney |
| Yoval-Sanchez 2022 Redox Biol | 2022 | Yoval-Sánchez B, Ansari F, James J, Niatsetskaya Z, Sosunov S, Filipenko P, Tikhonova IG, Ten V, Wittig I, Rafikov R, Galkin A (2022) Redox-dependent loss of flavin by mitochondria complex I is different in brain and heart. https://doi.org/10.1016/j.redox.2022.102258 | LEAK OXPHOS | NS | Isolated mitochondria | Mouse | Heart Nervous system |
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| Vaccari 2020 Eur J Appl Physiol | 2020 | Vaccari F, Passaro A, D'Amuri A, Sanz JM, Di Vece F, Capatti E, Magnesa B, Comelli M, Mavelli I, Grassi B, Fiori F, Bravo G, Avancini A, Parpinel M, Lazzer S (2020) Effects of 3-month high-intensity interval training vs. moderate endurance training and 4-month follow-up on fat metabolism, cardiorespiratory function and mitochondrial respiration in obese adults. Eur J Appl Physiol 120:1787-803. | LEAK OXPHOS ET | N S NS | Permeabilized tissue | Human | Skeletal muscle |
| Politis-Barber 2020 Am J Physiol Endocrinol Metab | 2020 | Politis-Barber V, Brunetta HS, Paglialunga S, Petrick HL, Holloway GP (2020) Long-term high-fat feeding exacerbates short-term increases in adipose mitochondrial reactive oxygen species, without impairing mitochondrial respiration. Am J Physiol Endocrinol Metab 319:E376-87. | LEAK OXPHOS | F N Gp NS | Permeabilized cells | Mouse | Fat |
| Falcao-Tebas 2020 J Physiol | 2020 | Falcão-Tebas F, Marin EC, Kuang J, Bishop DJ, McConell GK (2020) Maternal exercise attenuates the lower skeletal muscle glucose uptake and insulin secretion caused by paternal obesity in female adult rat offspring. J Physiol 598:4251-70. | LEAK OXPHOS ET | N NS ROX | Permeabilized tissue | Rat | Skeletal muscle |
| Dulac 2020 J Physiol | 2020 | Dulac M, Leduc-Gaudet JP, Reynaud O, Ayoub MB, Guérin A, Finkelchtein M, Hussain SN, Gouspillou G (2020) Drp1 knockdown induces severe muscle atrophy and remodelling, mitochondrial dysfunction, autophagy impairment and denervation . J Physiol 598:3691-710. | LEAK OXPHOS | N NS ROX | Permeabilized tissue | Mouse | Skeletal muscle |
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| Severo 2020 Life Sci | 2020 | Severo L, Godinho D, Machado F, Hartmann D, Fighera MR, Soares FA, Furian AF, Oliveira MS, Royes LF (2020) The role of mitochondrial bioenergetics and oxidative stress in depressive behavior in recurrent concussion model in mice. Life Sci 257:117991. | LEAK OXPHOS ET | N S NS ROX | Homogenate | Mouse | Nervous system |
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| Irion 2020 Stem Cells Int | 2020 | Irion CI, Martins EL, Christie MLA, de Andrade CBV, de Moraes ACN, Ferreira RP, Pimentel CF, Suhett GD, Campos de Carvalho AC, Lindoso RS, Vieyra A, Galina A, Goldenberg RCS (2020) Acute myocardial infarction reduces respiration in rat cardiac fibers, despite adipose tissue mesenchymal stromal cell transplant. Stem Cells Int 2020:4327965 . | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue | Rat | Heart |
| Rondot 2020 Thesis | 2020 | Rondot A (2020) Fuels for winter: the role of proline in overwintering bumblebee queens (Bombus impatiens). Master's Thesis 41. | LEAK OXPHOS | N S NS ROX | Permeabilized tissue | Hexapods | Skeletal muscle |
| Dawid 2020 Biochim Biophys Acta Bioenerg | 2020 | Dawid C, Weber D, Musiol E, Janas V, Baur S, Lang R, Fromme T (2020) Comparative assessment of purified saponins as permeabilization agents during respirometry. Biochim Biophys Acta Bioenerg 1861:148251. | LEAK ROUTINE OXPHOS ET | N S Gp NS ROX | Permeabilized cells Isolated mitochondria Intact cells | Human Mouse | Nervous system HEK |
| Parker 2020 Thesis | 2020 | Parker EP (2020) The effect of isoleucine supplementation of peripheral blood mononuclear cell metabolism in subjects with type 2 diabetes. URS Thesis 31. | LEAK ROUTINE OXPHOS ET | N S CIV NS ROX | Permeabilized cells Intact cells | Human | Blood cells |
| Keller 2020 Oxid Med Cell Longev | 2020 | Keller Amy, Hull Sara E, Elajaili Hanan, Johnston Aspen, Knaub Leslie A, Chun Ji hye, Walker Lori, Nozik-Grayck Eva, Reusch Jane EB (2020) (–)-Epicatechin modulates mitochondrial redox in vascular cell models of oxidative stress. Oxid Med Cell Longev 2020:6392629. | LEAK OXPHOS ET | N NS | Permeabilized cells | Human | Endothelial;epithelial;mesothelial cell |
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| Buch 2020 FASEB J | 2020 | Buch BT, Halling JF, Ringholm S, Gudiksen A, Kjøbsted R, Olsen MA, Wojtaszewski JFP, Pilegaard H (2020) Colchicine treatment impairs skeletal muscle mitochondrial function and insulin sensitivity in an age-specific manner. FASEB J 34:8653-70. | LEAK OXPHOS | N NS | Permeabilized tissue | Mouse | Skeletal muscle |
| Wefers 2020 Mol Metab | 2020 | Wefers J, Connell NJ, Fealy CE, Andriessen C, de Wit V, van Moorsel D, Moonen-Kornips E, Jörgensen JA, Hesselink MKC, Havekes B, Hoeks J, Schrauwen P (2020) Day-night rhythm of skeletal muscle metabolism is disturbed in older, metabolically compromised individuals. Mol Metab 41:101050. | LEAK OXPHOS ET | F N NS | Permeabilized tissue | Human | Skeletal muscle |
| Macasoi 2020 Oncol Rep | 2020 | Macașoi I, Pavel IZ, Moacă AE, Avram S, David LV, Coricovac D, Mioc A, Spandidos DA, Tsatsakis A, Șoica C, Dumitrașcu V, Dehelean C (2020) Mechanistic investigations of antitumor activity of a Rhodamine B‑oleanolic acid derivative bioconjugate. Oncol Rep 44:1169-83. | LEAK ROUTINE OXPHOS ET | N S NS ROX | Permeabilized cells Intact cells | Human | Endothelial;epithelial;mesothelial cell |
| Le 2020 J Biol Chem | 2020 | Le CH, Benage LG, Specht KS, Li Puma LC, Mulligan CM, Heuberger AL, Prenni JE, Claypool SM, Chatfield KC, Sparagna GC, Chicco AJ (2020) Tafazzin deficiency impairs CoA-dependent oxidative metabolism in cardiac mitochondria. J Biol Chem 295:12485-97. | LEAK OXPHOS | F N S NS | Intact organism | Human | Heart |
| Courtes 2020 Brain Res Bull | 2020 | Courtes AA, Gonçalves DF, Hartmann DD, da Rosa PC, Cassol G, Royes LFF, de Carvalho NR, Soares FAA (2020) Guanosine protects against behavioural and mitochondrial bioenergetic alterations after mild traumatic brain injury. Brain Res Bull 163:31-39. | LEAK OXPHOS ET | N S NS ROX | Homogenate | Rat | Nervous system |
| Weber 2020 FASEB J | 2020 | Weber M, Mera P, Casas J, Salvador J, Rodríguez A, Alonso S, Sebastián D, Soler-Vázquez MC, Montironi C, Recalde S, Fucho R, Calderón-Domínguez M, Mir JF, Bartrons R, Escola-Gil JC, Sánchez-Infantes D, Zorzano A, Llorente-Cortes V, Casals N, Valentí V, Frühbeck G, Herrero L, Serra D (2020) Liver CPT1A gene therapy reduces diet-induced hepatic steatosis in mice and highlights potential lipid biomarkers for human NAFLD. FASEB J 34:11816-37. | LEAK OXPHOS | N NS | Isolated mitochondria | Mouse | Liver |
| Brum 2020 Mol Neurobiol | 2020 | Brum EDS, Fialho MFP, Fischer SPM, Hartmann DD, Gonçalves DF, Scussel R, Machado-de-Ávila RA, Dalla Corte CL, Soares FAA, Oliveira SM (2020) Relevance of mitochondrial dysfunction in the reserpine-induced experimental fibromyalgia model. Mol Neurobiol 57:4202-17. | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue Homogenate | Mouse | Skeletal muscle Nervous system |
| Esselun 2020 Neuromolecular Med | 2020 | Esselun C, Dilberger B, Silaidos CV, Koch E, Schebb NH, Eckert GP (2020) A walnut diet in combination with enriched environment improves cognitive function and affects lipid metabolites in brain and liver of aged NMRI mice. Neuromolecular Med 23:140-60. | LEAK OXPHOS ET | N S CIV NS ROX | Isolated mitochondria | Mouse | Nervous system |
| McCommis 2020 Nat Metab | 2020 | McCommis KS, Kovacs A, Weinheimer CJ, Shew TM, Koves TR, Ilkayeva OR, Kamm DR, Pyles KD, King MT, Veech RL, DeBosch BJ, Muoio DM, Gross RW, Finck BN (2020) Nutritional modulation of heart failure in mitochondrial pyruvate carrier-deficient mice. Nat Metab 2:1232-47. https://doi.org/10.1038/s42255-020-00296-1 | LEAK OXPHOS | F N S NS | Permeabilized tissue Isolated mitochondria | Mouse | Heart |
| Kunz 2020 J Biol Chem | 2020 | Kunz HE, Dorschner JM, Berent TE, Meyer T, Wang X, Jatoi A, Kumar R, Lanza IR (2020) Methylarginine metabolites are associated with attenuated muscle protein synthesis in cancer-associated muscle wasting. J Biol Chem 295:17441-59. | LEAK ROUTINE OXPHOS ET | N NS ROX S | Permeabilized tissue Intact cells | Mouse | Skeletal muscle |
| Kupats 2020 Oxid Med Cell Longev | 2020 | Kupats E, Stelfa G, Zvejniece B, Grinberga S, Vavers E, Makrecka-Kuka M, Svalbe B, Zvejniece L, Dambrova M (2020) Mitochondrial-protective effects of R-phenibut after experimental traumatic brain injury. Oxid Med Cell Longev 2020:9364598. | LEAK OXPHOS ET | N S NS | Homogenate Isolated mitochondria | Mouse | Nervous system |
| Battaglia 2020 Cell Death Dis | 2020 | Battaglia CR, Cursano S, Calzia E, Catanese A, Boeckers TM (2020) Corticotropin-releasing hormone (CRH) alters mitochondrial morphology and function by activating the NF-kB-DRP1 axis in hippocampal neurons. Cell Death Dis 11:1004. | LEAK OXPHOS ET | N S CIV NS ROX | Intact cells | Rat | Nervous system |
| Wen 2020 Biomedicines | 2020 | Wen JJ, Cummins CB, Williams TP, Radhakrishnan RS (2020) The genetic evidence of burn-induced cardiac mitochondrial metabolism dysfunction . Biomedicines 8:E566. | LEAK OXPHOS ET | N S NS | Permeabilized tissue | Rat | Heart |
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| Woessner 2020 Thesis | 2020 | Woessner MN (2020) BEET-HF: The effects of dietary inorganic nitrate supplementation on aerobic exercise performance, vascular function, cardiac performance and mitochondrial respiration in patients with heart failure with reduced ejection fraction. PhD Thesis 198. | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue | Human | Skeletal muscle |
| Marquez 2020 J Am Heart Assoc | 2020 | Marquez AM, Morgan RW, Ko T, Landis WP, Hefti MM, Mavroudis CD, McManus MJ, Karlsson M, Starr J, Roberts AL, Lin Y, Nadkarni V, Licht DJ, Berg RA, Sutton RM, Kilbaugh TJ (2020) Oxygen exposure during cardiopulmonary resuscitation is associated with cerebral oxidative injury in a randomized, blinded, controlled, preclinical trial. J Am Heart Assoc 9:015032. | LEAK OXPHOS ET | N S CIV NS | Homogenate | Pig | Nervous system |
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| Hedges 2020 Biosci Rep | 2020 | Hedges CP, Pham T, Shetty B, Masson SWC, Hickey AJR, Shepherd PR, Merry TL (2020) Prolonged treatment with a PI3K p110α inhibitor causes sex- and tissue-dependent changes in antioxidant content, but does not affect mitochondrial function. https://doi.org/10.1042/bsr20201128 | LEAK OXPHOS ET | N CIV NS ROX | Permeabilized tissue | Mouse | Skeletal muscle Liver |
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| Musi 2020 Aging Cell | 2020 | Musi N, Valentine JM, Sickora KR, Baeuerle E, Thompson CS, Shen Q, Orr ME (2020) Tau protein aggregation is associated with cellular senescence in the brain. Aging Cell 17:e12840. | LEAK OXPHOS ET | N S NS ROX | Homogenate | Mouse | Nervous system |
| Silva-Rodrigues 2020 Free Radic Biol Med | 2020 | Silva-Rodrigues T, De-Souza-Ferreira E, Machado CM, Cabral-Braga B, Rodrigues-Ferreira C, Galina A (2020) Hyperglycemia in a Type 1 Diabetes Mellitus model causes a shift in mitochondria coupled-glucose phosphorylation and redox metabolism in rat brain. Free Radic Biol Med 160:796-806. | LEAK OXPHOS ET | N NS | Isolated mitochondria | Rat | Nervous system |
| Weaver 2020 Biol Lett | 2020 | Weaver RJ, Carrion G, Nix R, Maeda GP, Rabinowitz S, Iverson ENK, Thueson K, Havird JC (2020) High mitochondrial mutation rates in Silene are associated with nuclear-mediated changes in mitochondrial physiology. Biol Lett 16:20200450. | LEAK OXPHOS | N S CIV NS | Isolated mitochondria | Plants | |
| Miotto 2020 Am J Physiol Endocrinol Metab | 2020 | Miotto PM, Petrick HL, Holloway GP (2020) Acute insulin deprivation results in altered mitochondrial substrate sensitivity conducive to greater fatty acid transport. Am J Physiol Endocrinol Metab 319:E345-53. | OXPHOS LEAK | N NS F | Permeabilized tissue | Rat | Skeletal muscle |
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| Avila-Rojas 2020 Food Chem Toxicol | 2020 | Avila-Rojas SH, Aparicio-Trejo OE, Briones-Herrera A, Medina-Campos ON, Reyes-Fermín LM, Martínez-Klimova E, León-Contreras JC, Hernández-Pando R, Tapia E, Pedraza-Chaverri J (2020) Alterations in mitochondrial homeostasis in a potassium dichromate model of acute kidney injury and their mitigation by curcumin. Food Chem Toxicol 145:111774. | LEAK OXPHOS ET | N S NS ROX | Isolated mitochondria | Rat | Kidney |
| Russell 2020 Nutrients | 2020 | Russell JS, Griffith TA, Naghipour S, Vider J, Du Toit EF, Patel HH, Peart JN, Headrick JP (2020) Dietary α-linolenic acid counters cardioprotective dysfunction in diabetic mice: unconventional PUFA protection. Nutrients 12:E2679. | LEAK OXPHOS ET | N S NS | Homogenate | Mouse | Heart |
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| Lensu 2020 Nutrients | 2020 | Lensu S, Pariyani R, Mäkinen E, Yang B, Saleem W, Munukka E, Lehti M, Driuchina A, Lindén J, Tiirola M, Lahti L, Pekkala S (2020) Prebiotic xylo-oligosaccharides ameliorate high-fat-diet-induced hepatic steatosis in rats . Nutrients 12:E3225. | LEAK OXPHOS ET | N S NS ROX | Homogenate | Rat | Liver |
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| Pajuelo-Reguera 2020 Cells | 2020 | Pajuelo Reguera David, Čunátová Kristýna, Vrbacký Marek, Pecinová Alena, Houštěk Josef, Mráček Tomáš, Pecina Petr (2020) Cytochrome c oxidase subunit 4 isoform exchange results in modulation of oxygen affinity. Cells 9:E443. | OXPHOS ET | N S Gp NS Other combinations | Permeabilized cells Oxidase;biochemical oxidation | Human | HEK |
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| Groennebaek 2020 Cells | 2020 | Groennebaek T, Billeskov TB, Schytz CT, Jespersen NR, Bøtker HE, Olsen RKJ, Eldrup N, Nielsen J, Farup J, De Paoli FV, Vissing K (2020) Mitochondrial structure and function in the metabolic myopathy accompanying patients with critical limb ischemia. Cells 9:E570. | LEAK OXPHOS | N NS ROX | Permeabilized tissue | Human | Skeletal muscle |
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| Jayakumari 2020 J Diabetes | 2020 | Jayakumari NR, Rajendran RS, Sivasailam A, Vimala SS, Nanda S, Manjunatha S, Pillai VV, Karunakaran J, Gopala S (2020) Impaired substrate-mediated cardiac mitochondrial complex I respiration with unaltered regulation of fatty acid metabolism and oxidative stress status in type 2 diabetic Asian Indians. J Diabetes 12:542-55. | LEAK OXPHOS ET | F N S NS ROX | Isolated mitochondria | Human | Heart |
| Xia 2020 Biomed Res Int | 2020 | Xia W, Wang Q, Lu Y, Hu Y, Zhang X, Zhang J, Liu D, Song J, Zhu Z, Liu D, Zhang H (2020) Transient receptor potential channel canonical type 3 deficiency antagonizes myofibroblast transdifferentiation in vivo. Biomed Res Int 2020:1202189. | LEAK ROUTINE OXPHOS ET | N S NS ROX | Permeabilized cells Intact cells | Human | Fibroblast |
| Cornelissen 2020 Hum Mol Genet | 2020 | Cornelissen T, Spinazzi M, Martin S, Imberechts D, Vangheluwe P, Bird M, De Strooper B, Vandenberghe W (2020) CHCHD2 harboring the Parkinson's disease-linked T61I mutation precipitates inside mitochondria and induces precipitation of wild-type CHCHD2. Hum Mol Genet 29:1096-106. | LEAK OXPHOS ET | N S CIV NS ROX | Permeabilized cells | Human | Fibroblast |
| Larsen 2020 Acta Physiol (Oxf) | 2020 | Larsen FJ, Schiffer TA, Zinner C, Willis SJ, Morales-Alamo D, Calbet J, Boushel R, Holmberg HC (2020) Mitochondrial oxygen affinity increases after sprint interval training and is related to the improvement in peak oxygen uptake. https://doi.org/10.1111/apha.13463 | OXPHOS | N NS | Isolated mitochondria | Human | Skeletal muscle |
| Khamoui 2020 Physiol Genomics | 2020 | Khamoui AV, Tokmina-Roszyk D, Rossiter HB, Fields GB, Visavadiya NP (2020) Hepatic proteome analysis reveals altered mitochondrial metabolism and suppressed acyl-CoA synthetase-1 in colon-26 tumor-induced cachexia. Physiol Genomics 52:203-16. | LEAK OXPHOS ET | N NS | Intact cells | Mouse | Liver |
| Yadav 2020 Cell Death Dis | 2020 | Yadav SK, Kambis TN, Kar S, Park SY, Mishra PK (2020) MMP9 mediates acute hyperglycemia-induced human cardiac stem cell death by upregulating apoptosis and pyroptosis in vitro. Cell Death Dis 11:186. | LEAK OXPHOS ET | N CIV NS ROX | Permeabilized cells | Human | Heart Stem cells |
| Yurre 2020 Arq Bras Cardiol | 2020 | Yurre AR, Silva JDFD, Torres MKDS, Martins EL, Ramos IP, Silva WSFLD, Sarpa JDS, Guedes CCDS, Napoleão TH, Coelho LCBB, Paiva PMG, Medei E (2020) Evaluation of the cardiac effects of a water-soluble lectin (Wsmol) from Moringa oleifera seeds. Arq Bras Cardiol 114:1029-37. | LEAK OXPHOS | N NS ROX | Isolated mitochondria | Mouse | Heart |
| Baggio 2020 Neurotoxicology | 2020 | Baggio S, Zenki K, Martins Silva A, Dos Santos TG, Rech G, Lazzarotto G, Dias RD, Mussulini BH, Rico EP, de Oliveira DL (2020) Fetal alcohol spectrum disorders model alters the functionality of glutamatergic neurotransmission in adult zebrafish. Neurotoxicology 78:152-160. | LEAK OXPHOS ET | N S NS ROX | Homogenate | Zebrafish | Nervous system |
| Bloise 2020 Thyroid | 2020 | Bloise FF, Santos AT, Brito JT, Andrade CBV, Oliveira TS, Souza AF, Fontes KN, Silva JD, Blanco NG, Silva PL, Rocco PRM, Fliers E, Boelen A, da-Silva WS, Ortiga-Carvalho TM (2020) Sepsis impairs thyroid hormone signaling and mitochondrial function in the mouse diaphragm. Thyroid 30:1079-90. | LEAK OXPHOS ET | N CIV NS | Permeabilized tissue | Mouse | Skeletal muscle |
| Tichanek 2020 Sci Rep | 2020 | Tichanek F, Salomova M, Jedlicka J, Kuncova J, Pitule P, Macanova T, Petrankova Z, Tuma Z, Cendelin J (2020) Hippocampal mitochondrial dysfunction and psychiatric-relevant behavioral deficits in spinocerebellar ataxia 1 mouse model. Sci Rep 10:5418. | LEAK OXPHOS ET | N S CIV NS ROX | Homogenate | Mouse | Nervous system |
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| Gvozdjakova 2020 Diagnostics (Basel) | 2020 | Gvozdjáková A, Sumbalová Z, Kucharská J, Komlósi M, Rausová Z, Vančová O, Számošová M, Mojto V (2020) Platelet mitochondrial respiration, endogenous coenzyme Q10 and oxidative stress in patients with chronic kidney disease. Diagnostics (Basel) 10:176. | LEAK ROUTINE OXPHOS ET | N S NS ROX | Permeabilized cells Intact cells | Human | Platelet |
| Hraoui 2020 J Exp Biol | 2020 | Hraoui G, Bettinazzi S, Gendron AD, Boisclair D, Breton S (2020) Mitochondrial thermo-sensitivity in invasive and native freshwater mussels. J Exp Biol 223:jeb215921. | LEAK OXPHOS ET | N S CIV NS ROX | Permeabilized tissue | Molluscs | Lung;gill |
| Cassereau 2020 Exp Neurol | 2020 | Cassereau J, Chevrollier A, Codron P, Goizet C, Gueguen N, Verny C, Reynier P, Bonneau D, Lenaers G, Procaccio V (2020) Oxidative stress contributes differentially to the pathophysiology of Charcot-Marie-Tooth disease type 2K. Exp Neurol 323:113069. | LEAK OXPHOS ET | N S NS | Permeabilized cells | Human | Fibroblast |
| Oellermann 2020 Sci Rep | 2020 | Oellermann M, Hickey AJR, Fitzgibbon QP, Smith G (2020) Thermal sensitivity links to cellular cardiac decline in three spiny lobsters. Sci Rep 10:202. | LEAK OXPHOS ET | N S NS | Homogenate | Crustaceans | Heart |
| Roginski 2020 Biochim Biophys Acta Mol Basis Dis | 2020 | Roginski AC, Wajner A, Cecatto C, Wajner SM, Castilho RF, Wajner M, Amaral AU (2020) Disturbance of bioenergetics and calcium homeostasis provoked by metabolites accumulating in propionic acidemia in heart mitochondria of developing rats. Biochim Biophys Acta Mol Basis Dis 1866:165682. | LEAK OXPHOS ET | N S NS | Permeabilized cells Isolated mitochondria Homogenate | Rat | Heart Other cell lines |
| Pena 2020 Int J Chronic Dis | 2020 | Pena GS, Paez HG, Johnson TK, Halle JL, Carzoli JP, Visavadiya NP, Zourdos MC, Whitehurst MA, Khamoui AV (2020) Hippocampal growth factor and myokine cathepsin B expression following aerobic and resistance training in 3xTg-AD mice. Int J Chronic Dis 2020:Article ID 5919501. | LEAK OXPHOS ET | N S NS ROX | Homogenate | Mouse | Nervous system |
| No 2020 Pflugers Arch | 2020 | No MH, Heo JW, Yoo SZ, Kim CJ, Park DH, Kang JH, Seo DY, Han J, Kwak HB (2020) Effects of aging and exercise training on mitochondrial function and apoptosis in the rat heart. Pflugers Arch 472:179-93. | LEAK OXPHOS | N NS | Permeabilized tissue | Rat | Heart |
| Hartmann 2020 Free Radic Res | 2020 | Hartmann DD, Gonçalves DF, Da Rosa PC, Martins RP, Courtes AA, Franco JL, A Soares FA, Puntel GO (2020) A single muscle contusion promotes an immediate alteration in mitochondrial bioenergetics response in skeletal muscle fibres with different metabolism. Free Radic Res 54:137-49. | LEAK OXPHOS ET | N S NS | Permeabilized tissue | Rat | Skeletal muscle |
| Close 2020 Cells | 2020 | Close AF, Dadheech N, Lemieux H, Wang Q, Buteau J (2020) Disruption of beta-cell mitochondrial networks by the orphan nuclear receptor Nor1/Nr4a3. Cells 9:E168. | LEAK ROUTINE | N S CIV NS ROX | Permeabilized cells Intact cells | Rat | Islet cell;pancreas;thymus |
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| Dirks 2020 J Physiol | 2020 | Dirks ML, Miotto PM, Goossens GH, Senden JM, Petrick HL, van Kranenburg J, van Loon LJC, Holloway GP (2020) Short-term bed rest-induced insulin resistance cannot be explained by increased mitochondrial H2O2 emission. J Physiol 598:123-37. | LEAK OXPHOS | N NS | Permeabilized tissue | Human | Skeletal muscle |
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| Ost 2020 EMBO Rep | 2020 | Ost M, Igual Gil C, Coleman V, Keipert S, Efstathiou S, Vidic V, Weyers M, Klaus S (2020) Muscle-derived GDF15 drives diurnal anorexia and systemic metabolic remodeling during mitochondrial stress. EMBO Rep 21:e48804. | LEAK OXPHOS ET | N NS ROX | Permeabilized tissue | Mouse | Skeletal muscle |
| Baxter 2020 Elife | 2020 | Baxter M, Voronkov M, Poolman T, Galli G, Pinali C, Goosey L, Knight A, Krakowiak K, Maidstone R, Iqbal M, Zi M, Prehar S, Cartwright EJ, Gibbs J, Matthews LC, Adamson AD, Humphreys NE, Rebelo-Guiomar P, Minczuk M, Bechtold DA, Loudon A, Ray D (2020) Cardiac mitochondrial function depends on BUD23 mediated ribosome programming. Elife 9:e50705. | LEAK OXPHOS ET | N S CIV NS ROX | Homogenate | Mouse | Heart |
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| Makrecka-Kuka 2020 Cardiovasc Drugs Ther | 2020 | Makrecka-Kuka Marina, Korzh Stanislava, Videja Melita, Vilks Karlis, Cirule Helena, Kuka Janis, Dambrova Maija, Liepinsh Edgars (2020) Empagliflozin protects cardiac mitochondrial fatty acid metabolism in a mouse model of diet-induced lipid overload. Cardiovasc Drugs Ther 34:791-97. | OXPHOS ET | F N S NS ROX | Permeabilized tissue | Mouse | Heart |
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| Rebane-Klemm 2020 Cancers (Basel) | 2020 | Rebane-Klemm E, Truu L, Reinsalu L, Puurand M, Shevchuk I, Chekulayev V, Timohhina N, Tepp K, Bogovskaja J, Afanasjev V, Suurmaa K, Valvere V, Kaambre T (2020) Mitochondrial respiration in KRAS and BRAF mutated colorectal tumors and polyps. Cancers (Basel) 12:E815. | LEAK OXPHOS | N NS | Permeabilized tissue | Human | Endothelial;epithelial;mesothelial cell |
| Bose 2020 Aging Cell | 2020 | Bose C, Alves I, Singh P, Palade PT, Carvalho E, Børsheim E, Jun SR, Cheema A, Boerma M, Awasthi S, Singh SP (2020) Sulforaphane prevents age-associated cardiac and muscular dysfunction through Nrf2 signaling. Aging Cell 19:e13261. | LEAK OXPHOS | F N CIV NS ROX | Permeabilized tissue | Mouse | Heart |
| Purhonen 2020 Nat Commun | 2020 | Purhonen J, Grigorjev V, Ekiert R, Aho N, Rajendran J, Pietras R, Truvé K, Wikström M, Sharma V, Osyczka A, Fellman V, Kallijärvi J (2020) A spontaneous mitonuclear epistasis converging on Rieske Fe-S protein exacerbates complex III deficiency in mice. Nat Commun 11:322. | LEAK OXPHOS ET | N NS ROX | Isolated mitochondria | Mouse | Liver Kidney |
| Tepp 2020 Biochim Biophys Acta Gen Subj | 2020 | Tepp K, Puurand M, Timohhina N, Aid-Vanakova J, Reile I, Shevchuk I, Chekulayev V, Eimre M, Peet N, Kadaja L, Paju K, Kaambre T (2020) Adaptation of striated muscles to Wolframin deficiency in mice: Alterations in cellular bioenergetics. Biochim Biophys Acta Gen Subj 1864:129523. | LEAK OXPHOS ET | N S CIV NS ROX | Permeabilized tissue | Mouse | Heart Skeletal muscle |
| De-Souza 2020 J Biol Chem | 2020 | De-Souza EA, Pimentel FSA, De-Queiroz ALFV, Camara H, Felix-Formiga ML, Machado CM, Pinto S, Galina A, Mori MA, Montero-Lomelí M, Masuda CA (2020) The yeast protein Ubx4p contributes to mitochondrial respiration and lithium-galactose-mediated activation of the unfolded protein response. J Biol Chem 295:3773-82. | LEAK OXPHOS | N Gp NS ROX | Isolated mitochondria Intact cells | Caenorhabditis elegans Saccharomyces cerevisiae | |
| Almoiliqy 2020 Acta Pharmacol Sin | 2020 | Almoiliqy M, Wen J, Xu B, Sun YC, Lian MQ, Li YL, Qaed E, Al-Azab M, Chen DP, Shopit A, Wang L, Sun PY, Lin Y (2020) Cinnamaldehyde protects against rat intestinal ischemia/reperfusion injuries by synergistic inhibition of NF-κB and p53. Acta Pharmacol Sin 41:1208-22. | LEAK ROUTINE OXPHOS ET | N S NS ROX | Permeabilized cells Intact cells | Rat | Endothelial;epithelial;mesothelial cell |
| Boel 2020 J Exp Biol | 2020 | Boël M, Romestaing C, Duchamp C, Veyrunes F, Renaud S, Roussel D, Voituron Y (2020) Improved mitochondrial coupling as a response to high mass-specific metabolic rate in extremely small mammals. J Exp Biol 223:jeb215558. | LEAK ET | N NS | Permeabilized tissue | Mouse | Skeletal muscle |
| Li Puma 2020 Am J Physiol Regul Integr Comp Physiol | 2020 | Li Puma LC, Hedges M, Heckman JM, Mathias AB, Engstrom MR, Brown AB, Chicco AJ (2020) Experimental oxygen concentration influences rates of mitochondrial hydrogen peroxide release from cardiac and skeletal muscle preparations. Am J Physiol Regul Integr Comp Physiol 318:972-80. | LEAK OXPHOS | N NS | Permeabilized tissue Homogenate Isolated mitochondria | Mouse | Heart Skeletal muscle |
| Carvalho 2020 BMC Nutr | 2020 | Carvalho E, Adams SH, Borsheim E, Blackburn ML, Ono-Moore KD, Cotter M, Bowlin AK, Yeruva L (2020) Neonatal diet impacts liver mitochondrial bioenergetics in piglets fed formula or human milk. BMC Nutr 6:13. | LEAK OXPHOS | N NS ROX | Permeabilized tissue | Pig | Liver |
| Silaidos 2020 Mitochondrion | 2020 | Silaidos C, Grube J, Muley C, Eckert GP (2020) Time-dependent melatonin secretion is associated with mitochondrial function in peripheral blood mononuclear cells (PBMC) of male volunteers. Mitochondrion 53:21-29. | LEAK ROUTINE OXPHOS ET | N S CIV NS ROX | Permeabilized cells Intact cells | Human | Blood cells |
| MiPNet18.05 Amplex-Mouse-heart | 2019-06-24 | | LEAK OXPHOS ET | N S NS | Homogenate | Mouse | Heart |
| Chatfield 2019 JACC Basic Transl Sci | 2019 | Chatfield KC, Sparagna GC, Chau S, Phillips EK, Ambardekar AV, Aftab M, Mitchell MB, Sucharov CC, Miyamoto SD, Stauffer BL (2019) Elamipretide improves mitochondrial function in the failing human heart. JACC Basic Transl Sci 4:147-57. | LEAK OXPHOS ET | N S NS | Permeabilized tissue | Human | Heart |
| Doerrier 2019 MitoFit Preprint Arch EA | 2019 | Doerrier C, Gama-Perez P, Distefano G, Pesta D, Soendergaard SD, Chroeis KM, Gonzalez-Franquesa A, Goodpaster BH, Coen P, Larsen S, Gnaiger E, Garcia-Roves PM (2019) Inter-laboratory harmonization of respiratory protocols in permeabilized human muscle fibers. https://doi.org/10.26124/mitofit:ea19.MiPSchool.0009 | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue | Human | Skeletal muscle |
| Jaskiewicz 2019 J Clin Med | 2019 | Jaśkiewicz A, Pająk B, Łabieniec-Watała M, De Palma C, Orzechowski A (2019) Diverse action of selected statins on skeletal muscle cells - An attempt to explain the protective effect of geranylgeraniol (GGOH) in statin-associated myopathy (SAM). J Clin Med 8:694. | ROUTINE OXPHOS ET LEAK | N S NS ROX | Permeabilized cells Intact cells | Mouse | Skeletal muscle Other cell lines |
| Crescenzo 2019 Mol Neurobiol | 2019 | Crescenzo R, Spagnuolo MS, Cancelliere R, Iannotta L, Mazzoli A, Gatto C, Iossa S, Cigliano L (2019) Effect of initial aging and high-fat/high-fructose diet on mitochondrial bioenergetics and oxidative status in rat brain. Mol Neurobiol 56:7651-63. | LEAK OXPHOS ET | N S NS ROX | Homogenate | Rat | Nervous system |
| Gonzalez-Armenta 2019 J Nutr | 2019 | Gonzalez-Armenta JL, Gao Z, Appt SE, Vitolins MZ, Michalson KT, Register TC, Shively CA, Molina AJA (2019) Skeletal muscle mitochondrial respiration is elevated in female cynomolgus macaques fed a western compared with a mediterranean diet. J Nutr 149:1493-502. | LEAK OXPHOS ET | F N S Gp NS ROX | Permeabilized tissue | Other mammals | Skeletal muscle |
| Detaille 2019 PLoS One | 2019 | Detaille D, Pasdois P, Sémont A, Dos Santos P, Diolez P (2019) An old medicine as a new drug to prevent mitochondrial complex I from producing oxygen radicals. PLoS One 14:e0216385. | LEAK OXPHOS | N S NS ROX | Isolated mitochondria | Rat | Heart |
| Stepanova 2019 Antioxid Redox Signal | 2019 | Stepanova Anna, Sosunov S, Niatsetskaya Z, Konrad Csaba, Starkov AA, Manfredi G, Wittig I, Ten V, Galkin A (2019) Redox-dependent loss of flavin by mitochondrial complex I in brain ischemia/reperfusion injury. Antioxid Redox Signal 31:608-22. | LEAK OXPHOS | N NS | Isolated mitochondria | Mouse | Nervous system |
| Zhang 2019 Redox Biol | 2019 | Zhang Y, Bharathi SS, Beck ME, Goetzman ES (2019) The fatty acid oxidation enzyme long-chain acyl-CoA dehydrogenase can be a source of mitochondrial hydrogen peroxide. Redox Biol 26:101253. | LEAK OXPHOS | N NS F | Isolated mitochondria | Mouse | Liver |
| Ng 2019 J Biol Chem | 2019 | Ng J, Kaur H, Collier T, Chang K, Brooks AES, Allison JR, Brimble MA, Hickey A, Birch NP (2019) Site-specific glycations of Aβ1-42 affect fibril formation and are neurotoxic. J Biol Chem 294:8806-18. | LEAK OXPHOS ET | N S CIV NS ROX | Permeabilized cells | Human | Neuroblastoma |
| Neyroud 2019 J Muscle Res Cell Motil | 2019 | Neyroud D, Nosacka RL, Judge AR, Hepple RT (2019) Colon 26 adenocarcinoma (C26)-induced cancer cachexia impairs skeletal muscle mitochondrial function and content. J Muscle Res Cell Motil 40:59-65. | OXPHOS | N NS | Permeabilized cells | Mouse | Skeletal muscle |
| Scavuzzo 2019 J Neurophysiol | 2019 | Scavuzzo CJ, Leblancq MJ, Nargang F, Lemieux H, Hamilton TJ, Dickson CT (2019) The amnestic agent anisomycin disrupts intrinsic membrane properties of hippocampal neurons via a loss of cellular energetics. J Neurophysiol 122:1123-35. | LEAK OXPHOS | N S CIV NS ROX | Homogenate | Rat | Nervous system |
| Aubin 2019 Thesis | 2019 | Aubin M (2019) Glucocorticoids and acute lymphoid leukemia: a proteomic approach. Doctoral Dissertation 99. | ROUTINE OXPHOS ET | N S NS ROX | Intact cells Permeabilized cells | Human | Lymphocyte |
| Power 2019 PLoS One | 2019 | Power AS, Norman R, Jones TLM, Hickey AJ, Ward ML (2019) Mitochondrial function remains impaired in the hypertrophied right ventricle of pulmonary hypertensive rats following short duration metoprolol treatment. PLoS One 14:e0214740. | LEAK OXPHOS | N NS | Permeabilized tissue | Rat | Heart |
| Tetsi 2019 Antioxidants (Basel) | 2019 | Tetsi L, Charles AL, Georg I, Goupilleau F, Lejay A, Talha S, Maumy-Bertrand M, Lugnier C, Geny B (2019) Effect of the phosphodiesterase 5 inhibitor sildenafil on ischemia-reperfusion-induced muscle mitochondrial dysfunction and oxidative stress. Antioxidants (Basel) 8:E93. | LEAK OXPHOS | N CIV NS | Permeabilized tissue | Mouse | Skeletal muscle |
| Miotto 2019 FASEB J | 2019 | Miotto PM, McGlory C, Bahniwal R, Kamal M, Phillips SM, Holloway GP (2019) Supplementation with dietary ω-3 mitigates immobilization-induced reductions in skeletal muscle mitochondrial respiration in young women. FASEB J 33:8232-40. | LEAK OXPHOS | N NS F | Permeabilized tissue | Human | Skeletal muscle |
| Sundstroem 2019 Acta Neuropathol Commun | 2019 | Sundstrøm T, Prestegarden L, Azuaje F, Aasen SN, Røsland GV, Varughese JK, Bahador M, Bernatz S, Braun Y, Harter PN, Skaftnesmo KO, Ingham ES, Mahakian LM, Tam S, Tepper CG, Petersen K, Ferrara KW, Tronstad KJ, Lund-Johansen M, Beschorner R, Bjerkvig R, Thorsen F (2019) Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis. Acta Neuropathol Commun 7:55. | ET LEAK | N S NS ROX | Permeabilized cells | Human | Endothelial;epithelial;mesothelial cell |
| Itkis 2019 Mitochondrion | 2019 | Itkis Y, Krylova T, Pechatnikova NL, De Grassi A, Tabakov VY, Pierri CL, Aleshin V, Boyko A, Bunik VI, Zakharova EY (2019) A novel variant m.641A>T in the mitochondrial MT-TF gene is associated with epileptic encephalopathy in adolescent. Mitochondrion 47:10-17. | LEAK ROUTINE OXPHOS ET | N CIV NS ROX | Intact cells Permeabilized cells | Human | Fibroblast |
| McCoin 2019 Am J Physiol Endocrinol Metab | 2019 | McCoin CS, Von Schulze A, Allen J, Fuller KN, Xia Q, Koestler DC, Houchen CJ, Maurer A, Dorn Ii GW, Shankar K, Morris EM, Thyfault JP (2019) Sex modulates hepatic mitochondrial adaptations to high fat diet and physical activity. Am J Physiol Endocrinol Metab 317:E298-E311. | LEAK OXPHOS ET | F N NS | Isolated mitochondria | Mouse | Liver |
| De-Souza-Ferreira 2019 J Neurochem | 2019 | de-Souza-Ferreira E, Rios-Neto IM, Martins EL, Galina A (2019) Mitochondria-coupled glucose phosphorylation develops after birth to modulate H2O2 release and calcium handling in rat brain. J Neurochem 149:624-40. | LEAK OXPHOS ET | N Gp CIV NS | Isolated mitochondria | Rat | Nervous system |
| Pedrotti 2019 Sci Adv | 2019 | Pedrotti S, Caccia R, Neguembor MV, Garcia-Manteiga JM, Ferri G, de Palma C, Canu T, Giovarelli M, Marra P, Fiocchi A, Molineris I, Raso M, Sanvito F, Doglioni C, Esposito A, Clementi E, Gabellini D (2019) The Suv420h histone methyltransferases regulate PPAR-γ and energy expenditure in response to environmental stimuli. Sci Adv 5:eaav1472. | LEAK ROUTINE OXPHOS ET | N S NS ROX | Intact cells | Mouse | Fat |
| ... further results | |||||||
- »Abstracts: NS-pathway control state
Sort in ascending/descending order by a click on one of the small symbols in squares below.
| Year | Reference | Coupling | Pathway | Preparation | Organism | Tissue;cell | |
|---|---|---|---|---|---|---|---|
| Umbrasas 2024 Abstract IOC167 | 2024 | Umbrasas D, Pampuščenko K, Gružaitė J, Morkūnienė R, Smirnovas V, Borutaitė V (2024) Extracellular alpha-synuclein and S100A9 species cause a shift in microglial energy metabolism. Mitochondr Physiol Network 28.12. | N NS | Permeabilized cells | Mouse | Nervous system | |
| Sobotka 2024 EBEC | 2024 |  | ROUTINE LEAK OXPHOS ET | S NS | Permeabilized cells Intact cells | Human | |
| Cecatto 2023 BPS2023 San Diego | 2023 |  | OXPHOS | F N Gp NS | Permeabilized tissue Homogenate | Mouse | Heart Nervous system Kidney |
| Irving 2022 Abstract Bioblast | 2022 | 7.4. «5 min»   | LEAK OXPHOS ET | N Gp NS ROX | Permeabilized tissue Homogenate | Mouse | Nervous system |
| Magri 2022 Abstract Bioblast | 2022 | 8.5. «5 min»  | LEAK ROUTINE OXPHOS ET | N S NS ROX | Permeabilized cells Intact cells | Human | Nervous system |
| Cardoso 2022 Abstract Bioblast | 2022 | 4.3. «10+5»  | LEAK OXPHOS ET | N S NS ROX | Permeabilized cells Isolated mitochondria | Mouse | Liver HEK |
| Cardoso 2022 ESCI Bari | 2022 | | LEAK OXPHOS ET | N S NS | Permeabilized cells | Human | HEK |
| Cecatto 2022 EBEC | 2022 |  | LEAK OXPHOS ET | N S NS ROX | Isolated mitochondria | Mouse | Liver |
| Cardoso 2022a EBEC | 2022 | | LEAK OXPHOS ET | F N S NS | Permeabilized cells | Human | HEK |
| Doerrier 2020 PaduaMuscleDays Poster | 2020 | Doerrier C, Gama-Perez P, Chabi B, Ost M, Distefano G, Pesta D, Dahdah N, Lemieux H, Holody C, Carpenter RG, Tepp K, Puurand M, Kaambre T, Dubouchaud H, Cortade F, Calabria E, Casado M, Fernandez-Ortiz M, Acuna-Castroviejo D, Villena JA, Grefte S, Keijer J, O'Brien K, Sowton A, Murray AJ, Campbell MD, Marcinek DJ, Nollet E, Wuest R, Dayanidhi S, Soendergaard SD, Chroeis KM, Gonzalez-Franquesa A, Goodpaster BH, Coen PM, Larsen S, Gnaiger E, Garcia-Roves PM (2020) Commitment to reproducibility in mitochondrial respiration studies with permeabilized muscle fibers. PaduaMuscleDays. | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue | Human Mouse | Skeletal muscle |
| Kramer 2019 Abstract IOC141 | 2019 | Kramer P, Distefano G, Monte J, Mills A, Edmunds L, Jurczak M, Cummings SR, Kritchevsky S, Newman AB, Hepple RT, Goodpaster B, Coen PM, Molina A (2019) The Study of Muscle, Mobility, and Aging (SOMMA): A multi-institutional respirometry study. Mitochondr Physiol Network 24.02. | LEAK OXPHOS ET | N CIV NS ROX | Human | Skeletal muscle | |
| Van der Ende 2019 MiPschool Coimbra | 2019 |  | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue | Human | Skeletal muscle |
| Goncalves Debora 2019 MiPschool Coimbra | 2019 |  | LEAK OXPHOS ET | N S NS ROX | Homogenate | Drosophila | |
| Garcia-Roves 2019 MiPschool Coimbra | 2019 |  | LEAK OXPHOS ET | N S CIV NS ROX | Permeabilized tissue | Mouse | Skeletal muscle |
| Abdel-Rahman 2019 MiP2019 | 2019 | | ROUTINE OXPHOS | N NS | Intact cells | Human | Platelet |
| Gnaiger 2019 MiP2019 | 2019 |  | OXPHOS | NS | Intact organism Permeabilized tissue Isolated mitochondria | Human | Skeletal muscle |
| Lelcu 2019 MiP2019 | 2019 |  | LEAK OXPHOS ET | N NS ROX | Permeabilized cells | Human | Platelet |
| Holody 2019 MiP2019 | 2019 |  | N S NS | Permeabilized tissue | Rat | Heart | |
| Chabi 2019 MiP2019 | 2019 |  | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue | Mouse | Skeletal muscle |
| Doerrier 2019 MiP2019 | 2019 |  | LEAK ET | N S NS ROX | Permeabilized tissue | Human | Skeletal muscle |
| Lemieux 2019a MiP2019 | 2019 |  | LEAK OXPHOS ET | N S CIV NS | Other invertebrates | ||
| Sumbalova 2019a MiP2019 | 2019 |  | LEAK OXPHOS | F N S Gp CIV NS ROX | Intact cells | Human | Platelet |
| Sumbalova 2019b MiP2019 | 2019 | | LEAK OXPHOS | F N S Gp CIV NS ROX | Intact cells | Human | Platelet |
| Chicco 2018 MiP2018b | 2018 |  | OXPHOS | F N NS | Permeabilized tissue | Mouse | Heart |
| Pereira da Silva Grilo da Silva 2018 MiP2018 | 2018 |  | OXPHOS ET | F N S NS Other combinations | Permeabilized cells Isolated mitochondria | Human Mouse | Nervous system Liver Other cell lines |
| Doerrier 2018 MiP2018c | 2018 | | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue | Human | Skeletal muscle |
| Doerrier 2018 MiP2018a | 2018 | | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue | Mouse | Skeletal muscle |
| Gnaiger 2018 MiP2018 | 2018 |  | OXPHOS | N F S Gp DQ CIV NS Other combinations | |||
| Liu 2018 Atherosclerosis Suppl | 2018 | Liu D (2018) Enhanced Trpc3-mediated mitochondrial respiratory dysfunction by inhibition of mitochondria-hexokinase in monocytes from hypertension rats. Atherosclerosis Suppl. | ROUTINE OXPHOS ET | N NS | Intact cells | Rat | Blood cells |
| Votion 2018 MiP2018 | 2018 |  | OXPHOS | F N S NS | Intact cells | Horse | Skeletal muscle |
| Nemec 2018 MiP2018 | 2018 |  | LEAK | F N NS Other combinations | Permeabilized tissue | Human | Skeletal muscle |
| Doerrier 2018 EBEC2018 | 2018 | | LEAK ROUTINE OXPHOS ET | F N S Gp CIV NS Other combinations ROX | Permeabilized cells Homogenate Isolated mitochondria | Human Mouse | Heart Nervous system Blood cells HEK Platelet |
| Hunt 2018 J Urol | 2018 | Marked increase in mitochondrial respiration, hydrogen peroxide emitting potential and ATP production in the urothelium versus detrusor smooth muscle. | N S CIV NS | Intact cells | Mouse | Endothelial;epithelial;mesothelial cell | |
| Chang 2018 Life Sciences Meeting 2018 Innsbruck AT | 2018 | pH dependence of mitochondrial respiration and H2O2 production in oral cancer cells – a pilot study. | LEAK ROUTINE OXPHOS ET | F N S Gp CIV NS Other combinations ROX | Permeabilized cells | Human | HEK Kidney |
| Schoepf 2018 33rd Annual EAU Congress Copenhagen | 2018 | Shift of mitochondrial oxidative phosphorylation is associated with mtDNA mutational load in primary prostate cancer tissue. | LEAK OXPHOS ET | F N NS Other combinations ROX | Permeabilized cells Permeabilized tissue | Human | Genital |
| Dubouchaud 2018 MiPschool Tromso | 2018 |  | N CIV NS | Isolated mitochondria | Mouse | Heart | |
| Krajcova 2018 ICO134 | 2018 | Skeletal muscle bioenergetics in critically ill patients: effect of early rehabilitation on mitochondrial functions and insulin resistance during and 6 months after critical illness. | LEAK OXPHOS ET | N S NS ROX | Homogenate | Human | Skeletal muscle |
| Gnaiger 2018 AussieMit | 2018 | Komlodi Timea, Sobotka Ondrej, Doerrier Carolina, Gnaiger Erich (2018) Mitochondrial H2O2 production is low under tissue normoxia but high at in-vitro air-level oxygen pressure - comparison of LEAK and OXPHOS states. AussieMit 2018 Melbourne AU. | LEAK ROUTINE OXPHOS | NS | Isolated mitochondria Intact cells | Mouse Saccharomyces cerevisiae | Heart Nervous system |
| Gnaiger 2018 MiPschool Tromso A1 | 2018 | | LEAK ET OXPHOS | F N S Gp DQ CIV NS Other combinations | |||
| Garipi 2018 MiPschool Tromso E2 | 2018 | Phenotyping mitochondrial metabolism in Barrett’s metaplasia-dysplasia-adenocarcinoma sequence: respiratory capacity, extracelular proton flux and ROS production | LEAK ROUTINE OXPHOS ET | CIV NS ROX | Permeabilized cells Permeabilized tissue | Human | Endothelial;epithelial;mesothelial cell Other cell lines |
| Kidere 2018 MiPschool Tromso E2 | 2018 |  | N NS S | Isolated mitochondria | Human | Platelet | |
| Isola 2018 MiPschool Tromso C3 | 2018 |  | N CIV NS | Isolated mitochondria | Mouse | Heart | |
| Krajcova 2018 MiPschool Tromso E2 | 2018 |  | LEAK OXPHOS ET | N NS ROX | Homogenate | Human | Heart |
| Konopka 2018 FASEB J | 2018 | Konopka AR, Castor WM, Reid J, Schoenberg H, Laurin J, Wolff C, Hamilton K, Miller B (2018) Metformin blunts exercise-induced improvements in skeletal muscle mitochondrial respiration independent of changes in mitochondrial biogenesis. FASEB J. | OXPHOS ET | F N NS | Permeabilized tissue | Human | Skeletal muscle |
| Meszaros 2018 Mt Med Hinxton | 2018 | High-resolution mitochondrial oxygen kinetics as diagnostic tool in Complex IV impairments. | LEAK OXPHOS ET | N CIV NS | Isolated mitochondria | Mouse | Heart Nervous system Liver |
| Garcia-Roves 2018 MiP2018b | 2018 | | OXPHOS ET | N S NS ROX | Permeabilized tissue | Mouse | Skeletal muscle |
| Waldauf 2017 MITOEAGLE Obergurgl | 2017 |  | LEAK OXPHOS ET | F N S CIV NS | Homogenate | Human | Skeletal muscle |
| Labieniec-Watala 2017 MiP2017 | 2017 |  | OXPHOS ET | N S NS ROX | Permeabilized cells | Human | Genital |
| Gnaiger 2017 MiPschool A4 | 2017 | | F N S Gp CIV NS Other combinations ROX | Permeabilized cells Permeabilized tissue Isolated mitochondria | |||
| Gnaiger 2017 MiPschool C1 | 2017 | | N S CIV NS ROX | Permeabilized cells Permeabilized tissue Isolated mitochondria | |||
| Panajatovic 2017 IOC124 | 2017 | Role of PGC-1α associated mitochondrial biogenesis in statin-induced myotoxicity. | N S NS | Permeabilized tissue | Mouse | Skeletal muscle | |
| Nemec 2017 MiP2017 | 2017 | | LEAK | N NS | Permeabilized tissue | Human | Skeletal muscle |
| Scheiber 2017 Europ Heart J | 2017 | High-resolution respirometry in human endomyocardial biopsies to assess myocardial mitochondrial function. | OXPHOS | F N NS | Permeabilized tissue | Human | Heart |
| Nakajima 2017 Europ Heart J | 2017 | Mitochondrial dysfunction in epicardial adipose tissue; possible role in progression of coronary artery disease. | OXPHOS | F N NS | Permeabilized tissue | Human | Fat |
| Han 2017 MiP2017 | 2017 | | LEAK OXPHOS | S CIV NS | Rat | Nervous system | |
| Krajcova 2017 MITOEAGLE Obergurgl | 2017 | | LEAK OXPHOS ET | N NS | Homogenate | Human | |
| Chabi 2017 MITOEAGLE Obergurgl | 2017 | | LEAK | NS | Permeabilized tissue | Mouse | Skeletal muscle |
| Dubouchaud 2017 MITOEAGLE Obergurgl | 2017 | | NS | Isolated mitochondria | Rat | Skeletal muscle Liver | |
| Ukropec 2017 MITOEAGLE Obergurgl | 2017 | | LEAK OXPHOS ET | F N S Gp NS | Permeabilized cells | Skeletal muscle | |
| Keppner 2017 MiPschool Obergurgl | 2017 | | LEAK OXPHOS ET | N NS | Permeabilized cells | Blood cells | |
| Distefano 2017 MiPschool Obergurgl | 2017 |  | LEAK OXPHOS ET | F NS | Permeabilized tissue | Human | Skeletal muscle |
| Markova 2017 MiPschool Obergurgl | 2017 |  | LEAK OXPHOS | N S CIV NS ROX | Homogenate | Rat | Heart |
| Collins 2017 MiPschool Obergurgl | 2017 | | OXPHOS | F N S Gp CIV NS ROX | Intact cells | ||
| Han 2017 Abstract IOC122 | 2017 | Retinal mitochondria respiration defects precede hyperglycemia onset in type 2 diabetes. | OXPHOS | NS | Homogenate | Rat | Nervous system |
| Gnaiger 2017 Abstract EUROMIT2017 Cologne | 2017 |  | OXPHOS ET | N NS S | Human | Endothelial;epithelial;mesothelial cell Genital Fibroblast | |
| Brazdova 2017 MiP2017 | 2017 |  | F N NS | Isolated mitochondria | Fat | ||
| Gnaiger 2017 Abstract MitoEAGLE Barcelona | 2017 | | LEAK OXPHOS ET | N S NS | Permeabilized tissue | Human Mouse | Heart Genital |
| White 2017 J Anim Sci | 2017 | Influence of temperament on skeletal muscle mitochondrial capacity of Brahman cows. | OXPHOS ET | N S NS | Bovines | Skeletal muscle | |
| Schilling 2017 J Mol Cell Cardiol | 2017 | Loss of caveolin-1 alters cardiac mitochondrial function and increases susceptibility to stress. | OXPHOS | N CIV NS | Isolated mitochondria | Mouse | Heart |
| Lin 2017 FASEB J | 2017 | Mitochondrial respiration is fiber-type specific in skeletal muscles. | LEAK ROUTINE | N NS | Permeabilized tissue | Rat | Skeletal muscle |
| Larsen 2017 MiP2017 WG2 | 2017 |  | OXPHOS | N NS | Permeabilized tissue | Human | Skeletal muscle |
| Sobotka 2017 MiP2017 | 2017 | | OXPHOS ET | N NS | Isolated mitochondria | Rat | Liver |
| Meszaros 2017 MiP2017 | 2017 |  | LEAK OXPHOS ET | N NS | Isolated mitochondria | Mouse | Nervous system Liver Kidney |
| Komlodi 2017 MiP2017 | 2017 |  | LEAK OXPHOS | N NS | Isolated mitochondria | Mouse | Heart Nervous system |
| Irving 2017 MiP2017 | 2017 | | LEAK ROUTINE OXPHOS ET | N NS ROX | Blood cells | ||
| Doerrier 2017 MiP2017 C1 | 2017 | | LEAK ET | F N S CIV NS | Isolated mitochondria | Mouse | Heart |
| Doerrier 2017 MiP2017 WG2 | 2017 | | LEAK OXPHOS ET | N NS | Permeabilized tissue | Mouse | Skeletal muscle |
| Urban 2017 MiP2017 | 2017 | | F N NS | Homogenate | Human | Skeletal muscle | |
| Truu 2017 MiP2017 | 2017 |  | N NS | Permeabilized tissue | Human | ||
| Markova 2017 MiP2017 | 2017 | | LEAK OXPHOS | N S CIV NS ROX | Pig | Heart | |
| Kolonics 2017 MiP2017 | 2017 |  | OXPHOS | N NS | Mouse Plants | Heart Liver | |
| Garcia-Roves 2017 MiP2017 | 2017 | | OXPHOS ET | N S NS ROX | Permeabilized tissue | Mouse | Skeletal muscle |
| Laner 2016 Abstract Mito Xmas Meeting Innsbruck | 2016 | OXPHOS and ET capacity in permeabilized fibers of canine superathletes. | LEAK OXPHOS ET | F N S NS ROX | Permeabilized tissue | Dog | Skeletal muscle |
| Davies 2016 Abstract Proceedings of The Physiological Society | 2016 | Development of mitochondrial function in the cortex and cerebellum of the ovine fetus. | LEAK OXPHOS | N S NS | Homogenate | Bovines | Nervous system |
| Weber 2016 Abstract Mito Xmas Meeting Innsbruck | 2016 | Loss of PTEN in prostate cancer cells leads to a switch to succinate-mediated mitochondrial respiration associated with increased expression of NaDC3 and HIF-1alpha. | ROUTINE | N NS | Permeabilized cells Intact cells | Human Mouse | Genital |
| Sumbalova 2016 Abstract Mito Xmas Meeting Innsbruck | 2016 | Methods for evaluation of mitochondrial membrane potential with multi-sensor high-resolution respirometry: potentiometry vs fluorometry. | LEAK OXPHOS ET | F N S NS ROX | Mouse | Nervous system | |
| Doerrier 2016 Abstract MitoFit Science Camp 2016 | 2016 | Development of a SUIT reference protocol for OXPHOS analysis by high-resolution respirometry. | LEAK ROUTINE OXPHOS ET | F N S Gp CIV NS ROX | Permeabilized cells Permeabilized tissue Homogenate Isolated mitochondria | Human Mouse | Heart Blood cells HEK Platelet |
| Pileggi 2016 Abstract MitoFit Science Camp 2016 | 2016 | Voluntary exercise prevents high fat diet-induced cardiac mitochondrial dysfunction in male rats. | F N NS | Permeabilized tissue | Rat | Heart | |
| Chicco 2016a Abstract MitoFit Science Camp 2016 | 2016 | Oxygen dependence of H2O2 release from skeletal muscle and cardiac mitochondria: influence of sample preparation. | OXPHOS | NS | Permeabilized tissue Homogenate Isolated mitochondria | Mouse | Heart Skeletal muscle |
| Herminghaus 2016 Abstract MitoFit Science Camp 2016 | 2016 | Sterile laparotomy time-dependently modulates hepatic but not colonic mitochondrial function similar to moderate abdominal sepsis. | LEAK OXPHOS | N NS | Rat | Liver Endothelial;epithelial;mesothelial cell | |
| Markova 2016 Abstract MitoFit Science Camp 2016 | 2016 | Porcine hearts samples preparation: PBI-Shredder or saponin? | N S NS | Permeabilized tissue Homogenate | Pig | Heart | |
| Calzia 2016 Abstract MitoFit Science Camp 2016 | 2016 | Mitochondrial respiration shows tissue- and strain-specific aging in short- and long-lived N. furzeri strains. | LEAK OXPHOS ET | NS | Fishes | Heart Skeletal muscle Nervous system Liver | |
| Hoppel 2016c Abstract MitoFit Science Camp 2016 | 2016 | Mitochondrial respiration in permeabilized skin fibroblasts. | OXPHOS ET | N S CIV NS ROX | Permeabilized cells | Human | Endothelial;epithelial;mesothelial cell Fibroblast |
| Krumschnabel 2016b Abstract MitoFit Science Camp 2016 | 2016 | O2k-MultiSensor: Mitochondrial respiration media for HRR and simultaneous O2k-Fluorometry. | LEAK OXPHOS ET | N S NS ROX | Human | Kidney HEK | |
| Lamberti 2016 Abstract MitoFit Science Camp 2016 | 2016 | Development of a reference sample for HRR. | LEAK ROUTINE OXPHOS ET | F N S Gp CIV NS Other combinations ROX | Human | Kidney HEK | |
| Krumschnabel 2016a Abstract MitoFit Science Camp 2016 | 2016 | O2k-Protocols: Mitochondrial preparations for HRR. | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue Homogenate Isolated mitochondria | Mouse | Heart |
| Sumbalova 2016a Abstract MitoFit Science Camp 2016 | 2016 | Optimizing strategies on the malate concentration in SUIT protocols. | OXPHOS ET | N S NS | Rat | Nervous system | |
| Gnaiger 2016 Abstract UMDF2016 | 2016 | Schöpf B, Schäfer G, Weber A, Talasz H, Eder IE, Klocker H, Gnaiger E (2016) Oxidative phosphorylation and mitochondrial function differ between human prostate tissue and cultured cells. | LEAK OXPHOS ET | F N NS | Permeabilized cells Permeabilized tissue | Human | Endothelial;epithelial;mesothelial cell Genital Other cell lines Fibroblast |
| Laner 2016 Abstract MitoFit Science Camp 2016 | 2016 | OXPHOS and ET-capacity in permeabilized fibers of canine superathletes. Analysis of HRR data presenting unexpected challenges. | LEAK OXPHOS ET | F N S NS ROX | Permeabilized tissue | Dog | Skeletal muscle |
| Sumbalova 2016b Abstract MitoFit Science Camp 2016 | 2016 | Human blood cells: isolation and HRR. | LEAK ROUTINE OXPHOS ET | F N S Gp CIV NS Other combinations ROX | Permeabilized cells Intact cells | Human | Blood cells Lymphocyte Platelet |
| Soendergaard 2016 Abstract IOC109 | 2016 | Soendergaard SD (2016) Acute exposure of human muscle fibers to EPO or Actovegin has a marked effect on the mitochondrial respiratory capacity. Mitochondr Physiol Network 21.01. | OXPHOS ET | N NS | Permeabilized tissue | Human | Skeletal muscle |
| Sobotka 2016 Abstract IOC116 | 2016 | Sobotka O, Kucera Otto, Stankova P, Endlicher R, Nozickova K, Banni A, Cervinkova Z (2016) Mitochondrial respiration in fatty liver. Mitochondr Physiol Network 21.11 | LEAK OXPHOS ET | F N S Gp CIV NS Other combinations ROX | Isolated mitochondria | Rat | Liver |
| Sparagna 2016 Abstract IOC109 | 2016 | Sparagna GC (2016) Measuring cardiac mitochondrial function in pediatric patients before and after implantation of a left ventricular assist device. Mitochondr Physiol Network 21.01. | LEAK OXPHOS | N S NS | Human | Heart | |
| Laner 2015 Abstract MiPschool Greenville 2015 | 2015 | Comparative mitochondrial physiology: OXPHOS and ET capacity in permeabilized fibers of canine superathletes. | OXPHOS ET | F N S NS | Permeabilized tissue | Dog | Skeletal muscle |
| Laner 2015 Abstract MiP2015 | 2015 | Comparative mitochondrial physiology: OXPHOS and ET capacity in permeabilized fibers of canine superathletes. | LEAK OXPHOS ET | F N S NS ROX | Permeabilized tissue | Dog | Skeletal muscle |
| Hoppel 2015 Abstract MiP2015 | 2015 | Effects of ultramarathon performance on mitochondrial respiration in human platelets. | ROUTINE OXPHOS ET | N S NS | Permeabilized cells | Human | Blood cells Platelet |
| Gnaiger 2015 Abstract MiP2015 | 2015 | Mitochondrial function of cyropreserved HEK 293T cells: development of a reference sample for high-resolution respirometry. | LEAK ROUTINE OXPHOS ET | N S NS | Permeabilized cells Intact cells | Human | HEK |
| Sumbalova 2015 Abstract MiP2015 | 2015 | High-resolution measurement of mitochondrial membrane potential and respiration – comparison of potentiometric and fluorometric methods. | LEAK OXPHOS ET | N S NS | Isolated mitochondria | Mouse | Nervous system |
| Chang 2015 Abstract EB2015 | 2015 | Different effects of interval and continuous exercise regimens on capacity of mitochondria oxidative phosphorylation in lymphocyte. | F N NS | Permeabilized cells Intact cells | Human | Macrophage-derived | |
| Sheldon 2015 Abstract MiPschool Greenville 2015 | 2015 | eNOS is required to preserve hepatic mitochondrial function in western diet-induced nonalcoholic fatty liver disease. | LEAK OXPHOS ET | N NS | Mouse | Liver | |
| Maarman 2015 Abstract MiPschool Cape Town 2015 | 2015 | Characterisation of mitochondrial function in a model of pulmonary hypertension-induced right ventricular failure. | LEAK OXPHOS | N S NS | Isolated mitochondria | Rat | Heart |
| Laner 2015 Abstract MiPschool Cape Town 2015 | 2015 | The Oroboros Oxygraph-2k for high-resolution respirometry and O2k-Fluorometry: a new quality in OXPHOS analysis. | LEAK ROUTINE OXPHOS ET | N S NS | Isolated mitochondria Intact cells | Mouse Saccharomyces cerevisiae | Heart |
| Gnaiger 2015 Abstract MiPschool Cape Town 2015 | 2015 | The functional design of the electron transfer system (ETS) and mitochondrial respiratory control. | LEAK ROUTINE OXPHOS ET | N S NS | Permeabilized cells Permeabilized tissue Homogenate Isolated mitochondria | ||
| Brown 2015 Abstract MiPschool Cape Town 2015 | 2015 | Protection of post-ischemic mitochondrial bioenergetics by targeting cardiolipin-dependent membrane fluidity. | OXPHOS | N S NS | Intact organism Permeabilized tissue Isolated mitochondria | Rat | Heart |
| Kokassaar 2015 Eesti Arst | 2015 | Erinevused wolframiinidefitsiidiga ja normaalsete hiirte lihaste hingamisahelate komplekside aktiivsuses. | N NS | Permeabilized tissue | Skeletal muscle | ||
| Cannon 2015 Fatty Acid Oxidation O2k-Network Discussion Forum | 2015 | Cannon 2015 Fatty Acid Oxidation O2k-Network Discussion Forum | LEAK OXPHOS ET | F N S NS ROX | Permeabilized tissue | Human Mouse | Skeletal muscle |
| Wuest 2015 Fatty Acid Oxidation O2k-Network Discussion Forum | 2015 | Wuest 2015 Fatty Acid Oxidation O2k-Network Discussion Forum | OXPHOS ET | F N S NS ROX | Permeabilized tissue | Rat | Heart |
| Coen 2015 Fatty Acid Oxidation O2k-Network Discussion Forum | 2015 | Coen 2015 Fatty Acid Oxidation O2k-Network Discussion Forum | OXPHOS | F N NS | Permeabilized tissue | ||
| Ljubkovic 2015 Fatty Acid Oxidation O2k-Network Discussion Forum | 2015 | Ljubkovic 2015 Fatty Acid Oxidation O2k-Network Discussion Forum | OXPHOS ET | F N NS | Permeabilized tissue | Human | Heart |
| Chou 2015 Fatty Acid Oxidation O2k-Network Discussion Forum | 2015 | Chou 2015 Fatty Acid Oxidation O2k-Network Discussion Forum | OXPHOS ET | F N S NS ROX | Permeabilized cells Permeabilized tissue | Blood cells Lymphocyte Platelet | |
| Volodina 2014 Abstract MiP2014 | 2014 | Multipotent stromal cells injection improves rat liver regeneration through activation of mitochondrial functions after subtotal hepatectomy. | LEAK OXPHOS ET | N NS | Isolated mitochondria | Rat | Liver |
| Sumbalova 2014 Abstract MiP2014 | 2014 | Optimization of malate concentration for high-resolution respirometry: mitochondria from rat liver and brain. | OXPHOS ET | F N S NS | Isolated mitochondria | Rat | Nervous system Liver |
| Schoepf 2014 Abstract MiP2014 | 2014 | OXPHOS analysis in small prostate biopsies. | LEAK OXPHOS ET | N S CIV NS | Permeabilized tissue | Human | Genital |
| Burtscher 2014 Abstract MiP2014 | 2014 | Region-specific differences in Complex I- and Complex II-linked respiration in the mouse brain. | OXPHOS ET | N S CIV NS | Permeabilized tissue | Mouse | Nervous system |
| Coen 2014 Abstract MiP2014 | 2014 | Exercise improves insulin sensitivity and muscle mitochondrial respiration following Roux-en-Y gastric bypass surgery. | N NS | Permeabilized tissue | Human | Skeletal muscle | |
| Wohlwend 2014 Abstract MiP2014 | 2014 | Exercise modality specific mitochondrial adaptations in skeletal muscle of elderly people. | OXPHOS | N NS | Permeabilized cells | Human | Skeletal muscle |
| Doerrier 2014 Abstract SECF | 2014 | Evaluation of melatonin treatment in mitochondria of permeabilized myocardial fibers from septic mice. | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue Isolated mitochondria | Mouse | Heart |
| Volt 2014 Abstract The 2014 Ageing Summit | 2014 | Effects of melatonin on the age-dependent dysregulation of the Nf-Kb/Nlrp3 activation during sepsis. | N S NS | Permeabilized tissue | Mouse | Heart | |
| Larsen 2014 Abstract MiP2014 | 2014 | The effect of high intensity training on mitochondrial fat oxidation in skeletal muscle and subcutaneous adipose tissue. | OXPHOS | F N S NS | Permeabilized tissue | Human | Skeletal muscle Fat |
| Krumschnabel 2014 Abstract MiP2014 | 2014 | Simultaneous high-resolution measurement of mitochondrial respiration and hydrogen peroxide production. | LEAK OXPHOS ET | N S NS | Homogenate Isolated mitochondria | Mouse | Nervous system |
| Laner 2014 Abstract MiP2014 | 2014 | Cytochrome c flux control factor as a quality criterion in respiratory OXPHOS analysis in canine permeabilized fibers. | LEAK ROUTINE OXPHOS ET | N NS | Permeabilized tissue | Dog | Skeletal muscle |
| Irving 2013 Abstract MiP2013 | 2013 | Irving BA, Stahl R, Kane CJ, Chernousov M, Argyropoulos G, Carey D (2013) Sex differences in murine mitochondrial oxidative capacity following a 24 week high-fat diet. Mitochondr Physiol Network 18.08. | LEAK OXPHOS ET | N NS | Permeabilized tissue Homogenate | Mouse | Skeletal muscle Liver Fat |
| Garcia-Roves 2013 Abstract MiP2013 | 2013 | Garcia-Roves PM, Gonzalez-Franquesa A, Martinez-Navarro L, Fernandez-Ruiz R (2013) Metabolic flexibility before and after lifestyle intervention in a diet-induced type 2 diabetes animal model. Mitochondr Physiol Network 18.08. | LEAK OXPHOS ET | N S CIV NS | Permeabilized cells Permeabilized tissue Homogenate | Mouse | Skeletal muscle Nervous system Liver Islet cell;pancreas;thymus Fat |
| Hickey 2013 Abstract MiP2013 | 2013 | Hickey AJ, Iftikar FI, MacDonald J, Baker D (2013) Mitochondria in a changing climate? The role of mitochondrial in hyperthermic heart failure in different fish species. Mitochondr Physiol Network 18.08. | LEAK ROUTINE OXPHOS ET | N S CIV NS | Permeabilized tissue | Other mammals Fishes | Heart |
| Dzialowski 2013 Abstract MiP2013 | 2013 | Dzialowski EM, Ream S, Duquaine A, Sirsat TS, Goy Sirsat SK (2013) Mitochondrial function and the development of endothermy in the precocial Pekin duck (Anas pekin). Mitochondr Physiol Network 18.08. | LEAK OXPHOS ET | F N S NS | Intact organism Permeabilized tissue | Birds | Skeletal muscle |
| Darveau 2013 Abstract MiP2013 | 2013 | Darveau CA, Teulier L, Crevier J, Weber JM (2013) Diversity and evolution of mitochondrial metabolism: Proline as a metabolic reward for pollinators. Mitochondr Physiol Network 18.08. | OXPHOS | N S Gp NS Other combinations | Permeabilized tissue | Hexapods | Skeletal muscle |
| Boushel 2013 Abstract MiP2013 | 2013 | Boushel RC (2013) Convective O2 delivery, diffusion and mitochondrial OXPHOS components of VO2 during exercise in health and disease. Mitochondr Physiol Network 18.08. | OXPHOS | N S NS | Intact organism Permeabilized cells Permeabilized tissue | Human | Skeletal muscle |
| Shabalina 2013 Abstract IOC79 | 2013 | Shabalina IG (2013) Enhanced Complex I but low Complex II substrate-derived ROS production rates in mice, prematurely aging due to enhanced mitochondrial DNA mutation rate. Mitochondr Physiol Network 18.07 | LEAK OXPHOS ET | N S NS | Isolated mitochondria | Mouse | Heart Skeletal muscle Liver |
| Dohlmann 2013 Abstract IOC75 | 2013 | Dohlmann T (2013) Effects of high-intense interval training on mitochondrial respiratory capacity. Mitochondr Physiol Network 18.03. | NS | Permeabilized cells | Human | Skeletal muscle | |
| Hendricks 2013 Abstract MiP2013 | 2013 | Hendricks E, Nathan BP, Menze MA (2013) Bioenergetics of permeabilized and intact nerve cell terminals from ApoE deficient and wild type mice. Mitochondr Physiol Network 18.08. | LEAK ROUTINE OXPHOS ET | N S NS | Intact cells Permeabilized cells Isolated mitochondria | Mouse | Nervous system |
| Gnaiger 2013 Abstract MiP2013 | 2013 | Gnaiger E, Søndergaard H, Munch-Andersen T, Damsgaard R, Hagen C, Díez-Sánchez C, Ara I, Wright-Paradis C, Schrauwen P, Hesselink M, Calbet J, Christiansen M, Helge JW, Saltin B, Boushel R (2013) Biochemical coupling efficiency in permeabilized fibers from arm and leg muscle in Inuit versus Caucasians: A functional test of the uncoupling hypothesis in Greenland. Mitochondr Physiol Network 18.08. | LEAK OXPHOS ET | F N S NS | Permeabilized tissue | Human | Skeletal muscle |
| Wieckowski 2013 Abstract MiP2013 | 2013 | Wieckowski MR, Karkucinska-Wieckowska A, Wojtala A, Lebiedzinska M, Pronicki M, Duszynski J (2013) Mitochondrial bioenergetic parameters, reactive oxygen species production and the status of antioxidant defense system can be used to differentiate mitochondrial defects studied in the fibroblasts from patients with various mitochondrial disorders. Mitochondr Physiol Network 18.08. | ROUTINE | CIV NS | Intact cells | Human Mouse | Fibroblast |
| Camacho-Pereira 2013 Abstract IOC75 | 2013 | Camacho-Pereira J (2013) CD38 as a regulator of mitochondrial function. Mitochondr Physiol Network 18.03. | LEAK ROUTINE OXPHOS ET | N S NS | Intact cells Permeabilized cells Isolated mitochondria | Mouse | Liver HEK Macrophage-derived |
| Christen 2013 Abstract MiP2013 | 2013 | Christen F, Desrosiers V, Blier PU (2013) Thermal sensitivity of mitochondria from arctic charr heart: Mitochondrial respiration and ROS production. Mitochondr Physiol Network 18.08. | OXPHOS ET | N S CIV NS ROX | Isolated mitochondria | Other mammals Fishes | Heart |
| Lemieux 2013 Abstract MiP2013 | 2013 | Lemieux H, Warren BE, Lucchinetti E, Lou PH, Zhang L, Gandhi M, Clanachan AS, Zaugg M(2013) Early mitochondrial dysfunction associated with type 2 diabetes mellitus in the heart and skeletal muscle. Mitochondr Physiol Network 18.08. | OXPHOS | F N S CIV NS Other combinations | Permeabilized tissue | Rat | Heart Skeletal muscle |
| Matallo 2013 Abstract MiP2013 | 2013 | Matallo J, Gröger M, Wagner K, Wagner F, Radermacher P, Calzia E (2013) Effects of mechanical ventilation after blunt chest trauma on diaphragmatic mitochondrial respiration in chronically cigarette smoke exposed mice: A clinically relevant model? Mitochondr Physiol Network 18.08. | ET | NS | Homogenate | Mouse | Heart Skeletal muscle Lung;gill |
| Pichaud 2013 Abstract MiP2013 | 2013 | Pichaud N, Blier PU(2013) Importance of mitochondrial haplotypes in the expression of metabolic phenotypes under different conditions. Mitochondr Physiol Network 18.08. | LEAK OXPHOS ET | N S Gp CIV NS ROX | Permeabilized tissue | Drosophila Hexapods | Skeletal muscle |
| Votion 2013 Abstract MiP2013 | 2013 | Votion DM, Mouithys-Mickalad A, Ceusters Justine D, Lemieux H, Tosi I, Franck T, Art T, Niesten A, Serteyn D (2013) The challenge of understanding myopathies in horses using permeabilized muscle cells. Mitochondr Physiol Network 18.08. | OXPHOS ET | F N S NS ROX | Permeabilized tissue | Horse | Skeletal muscle |
| Cavalcanti de Albuquerque 2013 Abstract MiP2013 | 2013 | Cavalcanti de Albuquerque JP, Salvador IC, Martins EG, Jardim-Messeder D; Werneck de Castro JPS; Carvalho DP; Galina A (2013) Skeletal muscle mitochondrial function in ovariectomized rats: A time course study and the role of estrogen replacement. Mitochondr Physiol Network 18.08. | LEAK OXPHOS ET | F N S Gp NS ROX | Intact organism Permeabilized tissue | Rat | Skeletal muscle |
| Dela 2013 Abstract MiP2013 | 2013 | Dela F (2013) Glucose tolerance and skeletal muscle coenzyme Q(10). Mitochondr Physiol Network 18.08. | OXPHOS | N S NS | Permeabilized tissue | Human | Skeletal muscle |
| Krumschnabel 2013 Abstract MiP2013 | 2013 | Krumschnabel G, Eigentler A, Fontana-Ayoub M, Draxl A, Fasching M, Gnaiger E (2013) Tissue homogenates for respiratory OXPHOS analysis in comparative mitochondrial physiology: mouse and trout – heart and liver. Mitochondr Physiol Network 18.08. | LEAK OXPHOS ET | N S NS ROX | Homogenate | Mouse Fishes | Heart Nervous system Liver |
| Pecina 2013 Abstract MiP2013 | 2013 | Pecina P, Houšťková H, Mráček T, Pecinová A, Nůsková H, Tesařová M, Hansíková H, Janota J, Zeman J, Houštěk J (2013) The use of lymphocytes for diagnostics of mitochondrial oxidative phosphorylation disorders. Mitochondr Physiol Network 18.08. | LEAK OXPHOS ET | N S Gp NS Other combinations ROX | Permeabilized cells Homogenate | Human | Blood cells Lymphocyte |
| Laner 2013 ASMRM | 2013 | Laner V, Gradl P, Eigentler A, Fontana-Ayoub M, Fasching M, Gnaiger E (2013) The Oroboros O2k for high-resolution respirometry and O2k-Fluorometry: a new quality in OXPHOS analysis. ASMRM2013. | LEAK OXPHOS ET | N S NS | Homogenate | Mouse | Heart |
| Gnaiger 2013 Abstract Mito2013 | 2013 | Gnaiger E, Søndergaard H, Munch-Andersen T, Damsgaard R, Hagen C, Díez-Sánchez C, Ara I, Wright-Paradis C, Schrauwen P, Hesselink M, Calbet J, Christiansen M, Helge JW, Saltin B, Boushel R (2013) Conserved mitochondrial coupling efficiency and adaptive substrate control in Inuit and Caucasians: adaptation and acclimatization to the Arctic winter. | LEAK OXPHOS ET | F N S NS | Permeabilized tissue | Human | Skeletal muscle |
| Watala 2012 Abstract Bioblast | 2012 | Watala C, Przygodzki T, Siewiera K, Kassassir H, Talar M, Labieniec-Watala M (2012) Oxygen consumption in resting and activated blood platelets: platelet mitochondria and cyclooxygenases as compounding targets for high-resolution respirometry. Mitochondr Physiol Network 17.12. | ROUTINE ET | NS ROX | Isolated mitochondria Enzyme Intact cells | Human Rat | Endothelial;epithelial;mesothelial cell Blood cells Platelet |
| Votion 2012 Abstract Bioblast | 2012 | Votion DM (2012) The cause of atypical myopathy in grazing European horses revealed. Mitochondr Physiol Network 17.12. | OXPHOS | N S NS | Permeabilized cells | Horse | Skeletal muscle |
| Labieniec-Watala 2012 Abstract Bioblast | 2012 | Labieniec-Watala M, Siewiera K, Watala C (2012) Seasonal fluctuations affect the physiology of laboratory animals – facts and artifacts from the perspective of heart mitochondrial respiratory response to tested compounds. Mitochondr Physiol Network 17.12. | LEAK OXPHOS ET | N S NS | Homogenate Isolated mitochondria | Mouse Rat | Heart Liver Fibroblast |
| Hand 2012 Abstract Bioblast | 2012 | Patil Y, Gnaiger E, Hand SC (2012) Respiration in embryo lysates reveals diminished Complex I activity and inhibition of the phosphorylation system during diapause in Artemia franciscana. Mitochondr Physiol Network 17.12. | OXPHOS ET | N S NS | Homogenate | Artemia Crustaceans | |
| Galina 2012 Abstract Bioblast | 2012 | Simonin V, Galina A (2012) Nitric oxide inhibits succinate dehydrogenase-driven oxygen consumption in potato tuber mitochondria in an oxygen tension-independent manner. Mitochondr Physiol Network 17.12. | OXPHOS | N S NS | |||
| Doerrier 2012 Abstract Bioblast | 2012 | Doerrier C, Garcia JA, Escames G, Acuna-Castroviejo D (2012) Treatment with melatonin prevents myocardial mitochondrial dysfunction in experimental sepsis in mice. Mitochondr Physiol Network 17.12. | LEAK OXPHOS ET | N S NS | Permeabilized tissue | Mouse | Heart |
| Gnaiger 2012 Abstract-FEPS-Santiago de Compostela | 2012 | Gnaiger E (2012) Aging and mitochondrial physiology. The effect of exercise and caloric balance on oxidative phosphorylation (OXPHOS). Abstract FEPS, Santiago de Compostela, Spain. Symposium: Advances in Aging and Mitochondria Research. September 08-12. | F N S NS | Human Horse | |||
| Acuna-Castroviejo 2012 Abstract Bioblast | 2012 | Acuna-Castroviejo D (2012) Melatonin and the quality of life: the melatonin-mitochondrion connection. Mitochondr Physiol Network 17.12. | ROUTINE OXPHOS | N S NS | Intact organism Isolated mitochondria Intact cells | Mouse Rat | Heart Skeletal muscle Nervous system Liver |
| Dzialowski 2012 Abstract IOC72 | 2012 | Dzialowski EM, Sirsat T, Goy S (2012) T3: Does it really make the alligator go “Tick, Tock”? Mitochondr Physiol Network 17.13. | LEAK OXPHOS | N S NS | Isolated mitochondria | Reptiles | Heart Skeletal muscle |
| Irving 2012 Abstract IOC72 | 2012 | Irving BA (2012) AgRP deficient female mice have elevated body weight and hypothalamic mitochondrial oxidative capacity. Mitochondr Physiol Network 17.13. | OXPHOS | N S NS | Permeabilized tissue | Mouse Rat | Skeletal muscle Nervous system Liver Fat |
| Towheed 2012 Abstract IOC72 | 2012 | Towheed A (2012) Elucidating pathogenesis of ATP synthase dysfunction in a Drosophila model of mitochondrial encephalomyopathy. Mitochondr Physiol Network 17.13. | LEAK ROUTINE OXPHOS ET | N S NS | Intact organism Permeabilized tissue | Drosophila Hexapods | |
| Horscroft 2012 Abstract IOC72 | 2012 | Horscroft JA, Kotwica AO, Ashmore T, Colleoni F, Morash AJ, Gilbert E, Gnaiger E, Martin DS, Murray AJ (2012) Mitochondrial function at altitude in lowland Europeans and highland Sherpas. Mitochondr Physiol Network 17.13. | LEAK OXPHOS ET | N NS | Human | Skeletal muscle | |
| Jacobs 2012 Abstract Bioblast | 2012 | Jacobs R, Lundby C (2012) Mitochondria express enhanced quality as well as quantity in parallel with aerobic fitness across recreationally active individuals up to elite athletes. Mitochondr Physiol Network 17.12. | LEAK OXPHOS ET | F N S NS | Permeabilized cells | Human | Skeletal muscle |
| Mark 2012 Abstract Bioblast | 2012 | Mark FC, Strobel A, Poertner HO (2012) Ocean warming and acidification – when fish mitochondria turn sour. Mitochondr Physiol Network 17.12. | LEAK ROUTINE OXPHOS | N S CIV NS | Permeabilized tissue Isolated mitochondria | Fishes | Heart Liver |
| Horvath 2012 Abstract Bioblast | 2012 | Horvath G, Eigentler A, Gnaiger E, Tretter L (2012) Respiratory substrate effects on mitochondrial membrane potential - experiments with mouse cardiac muscle homogenate. Mitochondr Physiol Network 17.12. | LEAK OXPHOS ET | N S NS | Homogenate | Mouse | Heart |
| Sumbalova 2011 Abstract Mitochondrial Medicine | 2011 | Sumbalova Z, Fasching M, Gnaiger E (2011) Substrate control in mitochondrial respiration and regulation of mitochondrial membrane potential. Abstract Mitochondrial Medicine Chicago. | LEAK OXPHOS ET | N S NS | Homogenate Isolated mitochondria | Mouse | Nervous system |
| Pesta 2011Abstract Mitochondrial Medicine-Training | 2011 | Pesta D, Hoppel F, Macek C, Messner H, Faulhaber M, Kobel C, Parson W, Burtscher M, Schocke M, Gnaiger E (2011) Mitochondrial improvements after strength, endurance, and intermittend hypoxic training in sedentary humans. A respiratory study on permeabilized muscle fibers. Abstract Mitochondrial Medicine Chicago. | LEAK OXPHOS ET | F N S NS ROX | Permeabilized tissue | Human | Skeletal muscle |
| Gnaiger 2011 Abstract-Berlin | 2011 | Gnaiger E (2011) Fewer mitochondria - mitochondrial 'fever': Mitochondrial physiology and capacity of oxidative phosphorylation in active and sedentary life styles. Abstract Targeting Mitochondria Berlin. | F N S NS | Human | |||
| Gnaiger 2011 Abstract-MonteVerita | 2011 | Gnaiger E (2011) Mitochondrial respiratory capacity at maximum aerobic exercise levels: Are intracellular oxygen levels limiting? Abstract Monte Verita. | OXPHOS | N S NS | Human | ||
| Pesta 2010 MiP Abstract | 2010 | Pesta D, Faulhaber M, Burtscher M, Gnaiger E, Schocke M (2010) Investigation of muscle metabolism of the M. quadriceps via 31P MRS and high-resolution respirometry in connection with 10 weeks of strength and endurance training in normoxia and hypoxia. MiP2010. | LEAK OXPHOS ET | F N S NS | Human | ||
| Garedew 2006 Biochim Biophys Acta | 2006 | Garedew A, Lemieux H, Schachner T, Blier PU, Tardif J-C, Gnaiger E (2006) High excess capacity of cytochrome c oxidase in permeabilized fibers of the mouse heart. Biochim Biophys Acta, EBEC Short Reports Suppl 14 (2006):167-8. | OXPHOS | N S NS | Permeabilized tissue Enzyme Oxidase;biochemical oxidation | Mouse | Heart |
| Gnaiger 2005 Abstract MiP2005 | 2005 | Gnaiger Erich, Wright-Paradis C, Sondergaard H, Lundby C, Calbet Jose AL, Saltin Bengt, Helge J, Boushel R (2005) High-resolution respirometry in small biopsies of human muscle: correlations with body mass index and age. MiP2005. | OXPHOS ET | F N CIV NS | Permeabilized tissue | Human | Skeletal muscle |
SUITbrowser question: Maximum physiological capacity
- NS-OXPHOS capacity provides a physiologically relevant estimate of maximum mitochondrial respiratory capacity.
- Use the SUITbrowser to find the best protocol to answer this and other research questions.
MitoPedia concepts:
Respiratory state,
SUIT state,
Recommended
MitoPedia topics: Substrate and metabolite, EAGLE
