NS-pathway control state

high-resolution terminology - matching measurements at high-resolution

NS-pathway control state

Description

The NS-linked substrate state (or flux in the NS-linked substrate state, NS; Complex I&II) is induced in mt-preparations by addition of NADH-generating substrates (N-linked substrate state) in combination with succinate (S- or CII-linked). NS is the abbreviation for the combination of N- or NADH-linked substrates (CI-linked) and S- or succinate-linked substrates (CII-linked). This physiological substrate combination is required for partial reconstiturion of TCA cycle function and convergent electron-input into the Q-junction to compensate for metabolite depletion into the incubation medium. NS in combination exerts an additive effect of convergent electron flow in most types of mitochondria.

Abbreviation: NS

Reference: Gnaiger 2014 MitoPathways, Gnaiger_2009_Int J Biochem Cell Biol

MitoPedia concepts: Respiratory state 

MitoPedia O2k and high-resolution respirometry: "SUIT state" is not in the list (O2k hardware, DatLab, Oroboros QM, O2k-Open Support, O2k-Respirometry, O2k-FluoRespirometry) of allowed values for the "MitoPedia O2k and high-resolution respirometry" property. SUIT state"SUIT state" is not in the list (O2k hardware, DatLab, Oroboros QM, O2k-Open Support, O2k-Respirometry, O2k-FluoRespirometry) of allowed values for the "MitoPedia O2k and high-resolution respirometry" property. 

MitoPedia topics: Substrate and metabolite