Difference between revisions of "MitoEAGLE data: muscle"
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Revision as of 14:57, 27 April 2016
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Working Groups | Short-Term Scientific Missions | Management Committee | Members |  |
COST Action CA15203 (2016-2021): MitoEAGLE
Evolution-Age-Gender-Lifestyle-Environment: mitochondrial fitness mapping
MitoEAGLE data: muscle
WG2
- MITOEAGLE data repository in muscle and other tissues
WG2 Description
- During the past 10 years, a dramatically increasing number of studies report respirometric data on human muscle tissue (e.g. Christiansen 2015 Am J Physiol). Muscle mitochondrial function is particularly studied in genetically engineered mouse models of human diseases (e.g. Jelenik 2014 Diabetes). However, despite the many published data, lack of consistency often precludes quantitative comparison among data sets with permeabilized or homogenized muscle fibres or isolated mitochondria, normalized to either tissue wet weight, dry weight, protein content, citrate synthase activity or other mitochondrial markers. In the absence of validated conversion factors, these data remain largely unconnected and can only be qualitatively linked.
- The aim of WG2 will be to provide access to complete data sets for post-study statistical analysis and use harmonization tools (WG1) for standardized documentation, to initiate a data repository on muscle tissue from humans and model organisms in health and disease. Data sets shall be obtained from already published and new studies, prompting participating labs to report experimental details beyond those already published as far as possible (using tools such as PubMed Commons). As a result, specific protocols will be summarized for handling muscle tissue. Depending on specific interests, WG2 may decide to extend their focus to other tissue types.
WG2 Participants
Country City Contact Australia Melbourne Bishop David J Austria Innsbruck Laner Verena Austria Innsbruck Gnaiger Erich Austria Salzburg Mayr JA Austria Innsbruck Doerrier Carolina Belgium Leuven Bird Matthew Belgium Liege Votion Dominique-Marie Brazil Jaboticabal, SP Garcia Geovana S Brazil São Paulo Ferreira Julio Cesar B Canada Rimouski Vandermeeren E Canada Vancouver Boushel Robert C Canada Edmonton (Alberta) Lemieux Helene Canada Rimouski Blier Pierre U Canada Antigonish Kane Daniel A Croatia Zagreb Saric A Croatia Split Mihanovic I Czech Republic Pilsen Kuncova J Czech Republic Hradec Králové Waldauf P Czech Republic Pilsen Markova Michaela Czech Republic Prague Elkalaf Moustafa Czech Republic Prague 10 Krajcova Adela Denmark Hvidovre Nehlin Jan O Denmark Copenhagen Gonzalez-Franquesa Alba Denmark Malov Hey-Mogensen M Denmark Copenhagen Dela Flemming Denmark Copenhagen Larsen Steen Denmark Copenhagen N Mortensen OH Estonia Tartu Paju Kalju Estonia Tallinn Puurand Marju Estonia Tallinn Truu Laura Estonia Tallinn Kaambre Tuuli Estonia Tallinn Vendelin Marko Estonia Tallinn Aid-Vanakova Jekaterina Estonia Tallinn Tepp Kersti Estonia Tallinn Karro N Finland Helsinki Pirinen E Finland Jyvaeskylae Lehti Maarit France Montpellier Cortade F France Paris Armand Anne-Sophie France Paris Petit Patrice X France Bordeaux cedex Mourier A France Grenoble Cedex 9 Schlattner Uwe France Grenoble cedex 9 Dubouchaud Herve France Montpellier Cedex 1 Chabi Beatrice France Paris Ventura-Clapier R Germany Düsseldorf Granata Cesare Germany Duesseldorf Jelenik T Germany Köln Kimoloi Sammy Germany Duesseldorf Roden Michael Germany Bremerhaven Mark Felix Christopher Germany Leipzig Ost Mario Germany Rostock Haider F Germany Cologne Pesta Dominik Germany Nuthetal Klaus S Germany Munich Jastroch M Germany Bochum Platen P Greece Heraklio Sidiropoulou K Greece Athens Trougakos Ioannis P Greece Heraklion Tavernarakis Nektarios India Haryana Sharma Vipin Ireland Sligo Murphy J Ireland Dublin O'Gorman Donal Ireland Dublin Porter Richard K Israel Rishon Le Zion Hachmo Yafit Israel Zrifin Sova Marina Israel Jerusalem Saada Reisch Ann Italia Udine Salvadego Desy Italy Milan De Palma Clara Italy Milan Giovarelli Matteo Italy Bologna Genova Maria Luisa Italy Pisa Gastaldelli Amalia Italy Rome Scatena Roberto Italy Novara Reano Simone Japan Sapporo Shirakawa R Japan Sapporo Nambu H Japan Sapporo Maekawa S Latvia Riga Liepins Edgars Latvia Riga Kuka Janis Latvia Riga Zvejniece Liga Latvia Riga Inashkina I Luxembourg Strassen Devaux Yvan Malta Msida Vella Joanna Netherlands Amsterdam De Goede Paul Netherlands Maastricht Grevendonk L Netherlands Maastricht Hoeks Joris Netherlands BT Amsterdam Jaspers Richard T Netherlands Maastricht Van Polanen N Netherlands Wageningen Keijer Jaap Niederlande ER Masstricht De Wit-Verheggen V Niederlande ER Masstricht De Theije C Norway Tromsoe Aasum E Norway Oslo Lund Jenny Norway Oslo Torp May-Kristin Norway Oslo Nikolic N Norway Tromsoe Jansen Kirsten M Norway Oslo Rustan AC Norway Bergen Tronstad Karl Johan Norway Oslo Eide L Norway Tromsoe Schots Pauke C Norway Ullevål Heiestad Christina Norway Tromsoe Larsen Terje S Poland Warsaw Dymkowska Dorota Poland Lodz Watala Cezary Poland Lodz Labieniec-Watala Magdalena Poland Warsaw Sek Aleksandra Poland Warsaw Kampa Rafal Pawel Portugal Coimbra Carvalho Eugenia Portugal Coimbra Pereira Susana P Portugal Porto Beleza Jorge Portugal Cantanhede Martins Joao D Portugal Coimbra Martins Marques T Portugal Cantanhede Ferreira LL Portugal Coimbra Palmeira Carlos Portugal Porto Coxito Pedro Portugal Porto Magalhaes Jose Romania Timisoara Muntean Danina M Romania Timisoara Lighezan R Singapore Singapore Hausenloy Derek J Slovakia Bratislava Ukropec J Slovakia Bratislava Sumbalova Zuzana Slovakia Bratislava Ukropcova B Slovakia Bratislava Maderova D Slovakia Bratislava Nemec Michal Slovenia Ljubljana Mars T Slovenia Ljubljana Pirkmajer Sergej Slovenia Ljubljana Dolinar K South Africa Smith James Spain Barcelona Zorzano Antonio Spain Barcelona Batlle M Spain Armilla (Granada) Fernandez-Ortiz Marisol Spain Barcelona Gama Perez Pau Spain Armilla (Granada) Acuna-Castroviejo Dario Spain A Coruña Blanco FJ Spain Barcelona Garcia-Roves Pablo Miguel Spain Barcelona Guitart M Spain Armilla, Granada Escames Germaine Spain Granada Lopez Garcia Luis Carlos Spain Madrid Moran M Spain Barcelona Sebastian D Spain Madrid Cadenas S Spain Barcelona De la Torre Lara J Spain Sevilla Bustos Matilde Spain Barcelona Catalan M Sweden Stockholm Cardinale Daniele A Sweden Linköping Fontes-Oliveira CC Switzerland Lausanne Morato Fornaguera L Switzerland Lausanne Sandi Carmen Switzerland Bern Nuoffer Jean-Marc Switzerland Lausanne Weger M Switzerland Lausanne Zalachoras I Switzerland Lausanne Gebara E The Netherlands Wageningen Van der Ende Miranda The Netherlands BT Amsterdam Wuest Rob CI Turkey Ankara Tuncay Erkan USA Ann Arbor Beard Daniel A USA Norfolk Lai Nicola USA Gainesville Hepple Russell T USA Boca Raton Khamoui Andy V USA Orlando Distefano Giovanna USA St Louis Welch R USA College Station Latham C USA Gainesville Neyroud D USA Baton Rouge Axelrod Christopher L USA Little Rock Porter Craig USA Orlando Coen Paul M USA Gainesville Wohlgemuth Stephanie E USA Chicago Dayanidhi Sudarshan USA Torrance Rossiter Harry B USA Fairbanks O'Brien Kristin USA Fort Collins Chicco Adam J USA Baltimore Gonzalez-Freire Marta USA Baton Rouge Irving Brian A USA College Station White-Springer Sarah H USA Baltimore Fang Evandro F USA Colorado Springs Jacobs RA United Kingdom Birmingham Joanisse S United Kingdom Manchester Giakoumaki I United Kingdom London Szabadkai Gyorgy United Kingdom Loughborough Ebanks Brad United Kingdom Plymouth, Devon McKenna Helen T United Kingdom Birmingham Garten Antje United Kingdom Birmingham Thakker A United Kingdom Brighton Moore Anthony L United Kingdom Nottingham Chakrabarti Lisa United Kingdom Cambridge Shiroma Jonathan G United Kingdom Leeds Boyle JP United Kingdom Cambridge Murray Andrew James United Kingdom Birmingham Ashcroft S United Kingdom Oxford Makrecka-Kuka Marina United States Providence Siamwala J
WG2 Management
Tasks
- Call for participating labs to deliver relevant experimental data on already published studies and to report them in a standardized format.
- Collection and indexing of the data sets as required for statistical analysis.
- Discussion of procedures, protocols and general guidelines.
- Draft a comprehensive review on mt-function in muscle tissue (registration at PROSPERO, link with EQUATOR).
- Opening of the database to the research public for data search and moderated entry of new data sets.
Milestones
- Call for data report delivered.
- Data sets entered in standardized format.
- Summary, interpretation and discussion of data for review.
Deliverables
- A MITOEAGLE database on muscle tissue from humans and model organisms.
- A set of guidelines for future studies on mitochondrial bioenergetics in muscle tissue.
- Draft of review manuscript.
Projects in progress
- » MiPMap
