Difference between revisions of "MitoEAGLE data: muscle"
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:::: The aim of WG2 will be to provide access to complete data sets for post-study statistical analysis and use harmonization tools (WG1) for standardized documentation, to initiate a data repository on muscle tissue from humans and model organisms in health and disease. Data sets shall be obtained from already published and new studies, prompting participating labs to report experimental details beyond those already published as far as possible (using tools such as PubMed Commons). As a result, specific protocols will be summarized for handling muscle tissue. Depending on specific interests, WG2 may decide to extend their focus to other tissue types. | :::: The aim of WG2 will be to provide access to complete data sets for post-study statistical analysis and use harmonization tools (WG1) for standardized documentation, to initiate a data repository on muscle tissue from humans and model organisms in health and disease. Data sets shall be obtained from already published and new studies, prompting participating labs to report experimental details beyond those already published as far as possible (using tools such as PubMed Commons). As a result, specific protocols will be summarized for handling muscle tissue. Depending on specific interests, WG2 may decide to extend their focus to other tissue types. | ||
== WG2 Participants == | |||
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== WG2 Management == | |||
=== Tasks === | === Tasks === | ||
Revision as of 14:52, 27 April 2016
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News and Events |  |
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Working Groups | Short-Term Scientific Missions | Management Committee | Members |  |
COST Action CA15203 (2016-2021): MitoEAGLE
Evolution-Age-Gender-Lifestyle-Environment: mitochondrial fitness mapping
MitoEAGLE data: muscle
WG2
- MITOEAGLE data repository in muscle and other tissues
WG2 Description
- During the past 10 years, a dramatically increasing number of studies report respirometric data on human muscle tissue (e.g. Christiansen 2015 Am J Physiol). Muscle mitochondrial function is particularly studied in genetically engineered mouse models of human diseases (e.g. Jelenik 2014 Diabetes). However, despite the many published data, lack of consistency often precludes quantitative comparison among data sets with permeabilized or homogenized muscle fibres or isolated mitochondria, normalized to either tissue wet weight, dry weight, protein content, citrate synthase activity or other mitochondrial markers. In the absence of validated conversion factors, these data remain largely unconnected and can only be qualitatively linked.
- The aim of WG2 will be to provide access to complete data sets for post-study statistical analysis and use harmonization tools (WG1) for standardized documentation, to initiate a data repository on muscle tissue from humans and model organisms in health and disease. Data sets shall be obtained from already published and new studies, prompting participating labs to report experimental details beyond those already published as far as possible (using tools such as PubMed Commons). As a result, specific protocols will be summarized for handling muscle tissue. Depending on specific interests, WG2 may decide to extend their focus to other tissue types.
WG2 Participants
| Country | City | Contact |
|---|---|---|
| Australia | Melbourne | Bishop David J |
| Austria | Innsbruck | Laner Verena |
| Austria | Innsbruck | Gnaiger Erich |
| Austria | Salzburg | Mayr JA |
| Austria | Innsbruck | Doerrier Carolina |
| Belgium | Leuven | Bird Matthew |
| Belgium | Liege | Votion Dominique-Marie |
| Brazil | São Paulo | Ferreira Julio Cesar B |
| Brazil | Jaboticabal, SP | Garcia Geovana S |
| Canada | Rimouski | Vandermeeren E |
| Canada | Vancouver | Boushel Robert C |
| Canada | Edmonton (Alberta) | Lemieux Helene |
| Canada | Rimouski | Blier Pierre U |
| Canada | Antigonish | Kane Daniel A |
| Croatia | Zagreb | Saric A |
| Croatia | Split | Mihanovic I |
| Czech Republic | Pilsen | Kuncova J |
| Czech Republic | Hradec Králové | Waldauf P |
| Czech Republic | Pilsen | Markova Michaela |
| Czech Republic | Prague 10 | Krajcova Adela |
| Czech Republic | Prague | Elkalaf Moustafa |
| Denmark | Hvidovre | Nehlin Jan O |
| Denmark | Copenhagen | Gonzalez-Franquesa Alba |
| Denmark | Malov | Hey-Mogensen M |
| Denmark | Copenhagen | Dela Flemming |
| Denmark | Copenhagen | Larsen Steen |
| Denmark | Copenhagen N | Mortensen OH |
| Estonia | Tallinn | Karro N |
| Estonia | Tallinn | Puurand Marju |
| Estonia | Tartu | Paju Kalju |
| Estonia | Tallinn | Truu Laura |
| Estonia | Tallinn | Kaambre Tuuli |
| Estonia | Tallinn | Vendelin Marko |
| Estonia | Tallinn | Tepp Kersti |
| Estonia | Tallinn | Aid-Vanakova Jekaterina |
| Finland | Helsinki | Pirinen E |
| Finland | Jyvaeskylae | Lehti Maarit |
| France | Montpellier | Cortade F |
| France | Paris | Armand Anne-Sophie |
| France | Paris | Petit Patrice X |
| France | Bordeaux cedex | Mourier A |
| France | Grenoble Cedex 9 | Schlattner Uwe |
| France | Montpellier Cedex 1 | Chabi Beatrice |
| France | Paris | Ventura-Clapier R |
| France | Grenoble cedex 9 | Dubouchaud Herve |
| Germany | Düsseldorf | Granata Cesare |
| Germany | Duesseldorf | Jelenik T |
| Germany | Duesseldorf | Roden Michael |
| Germany | Köln | Kimoloi Sammy |
| Germany | Leipzig | Ost Mario |
| Germany | Rostock | Haider F |
| Germany | Bremerhaven | Mark Felix Christopher |
| Germany | Cologne | Pesta Dominik |
| Germany | Nuthetal | Klaus S |
| Germany | Munich | Jastroch M |
| Germany | Bochum | Platen P |
| Greece | Heraklio | Sidiropoulou K |
| Greece | Athens | Trougakos Ioannis P |
| Greece | Heraklion | Tavernarakis Nektarios |
| India | Haryana | Sharma Vipin |
| Ireland | Sligo | Murphy J |
| Ireland | Dublin | O'Gorman Donal |
| Ireland | Dublin | Porter Richard K |
| Israel | Rishon Le Zion | Hachmo Yafit |
| Israel | Zrifin | Sova Marina |
| Israel | Jerusalem | Saada Reisch Ann |
| Italia | Udine | Salvadego Desy |
| Italy | Milan | De Palma Clara |
| Italy | Milan | Giovarelli Matteo |
| Italy | Bologna | Genova Maria Luisa |
| Italy | Pisa | Gastaldelli Amalia |
| Italy | Rome | Scatena Roberto |
| Italy | Novara | Reano Simone |
| Japan | Sapporo | Shirakawa R |
| Japan | Sapporo | Nambu H |
| Japan | Sapporo | Maekawa S |
| Latvia | Riga | Liepins Edgars |
| Latvia | Riga | Inashkina I |
| Latvia | Riga | Kuka Janis |
| Latvia | Riga | Zvejniece Liga |
| Luxembourg | Strassen | Devaux Yvan |
| Malta | Msida | Vella Joanna |
| Netherlands | Amsterdam | De Goede Paul |
| Netherlands | Maastricht | Grevendonk L |
| Netherlands | Maastricht | Hoeks Joris |
| Netherlands | Maastricht | Van Polanen N |
| Netherlands | Wageningen | Keijer Jaap |
| Netherlands | BT Amsterdam | Jaspers Richard T |
| Niederlande | ER Masstricht | De Wit-Verheggen V |
| Niederlande | ER Masstricht | De Theije C |
| Norway | Ullevål | Heiestad Christina |
| Norway | Oslo | Nikolic N |
| Norway | Oslo | Lund Jenny |
| Norway | Oslo | Torp May-Kristin |
| Norway | Oslo | Rustan AC |
| Norway | Tromsoe | Jansen Kirsten M |
| Norway | Bergen | Tronstad Karl Johan |
| Norway | Oslo | Eide L |
| Norway | Tromsoe | Larsen Terje S |
| Norway | Tromsoe | Aasum E |
| Norway | Tromsoe | Schots Pauke C |
| Poland | Warsaw | Dymkowska Dorota |
| Poland | Lodz | Watala Cezary |
| Poland | Lodz | Labieniec-Watala Magdalena |
| Poland | Warsaw | Sek Aleksandra |
| Poland | Warsaw | Kampa Rafal Pawel |
| Portugal | Porto | Magalhaes Jose |
| Portugal | Coimbra | Pereira Susana P |
| Portugal | Porto | Beleza Jorge |
| Portugal | Cantanhede | Martins Joao D |
| Portugal | Coimbra | Palmeira Carlos |
| Portugal | Coimbra | Martins Marques T |
| Portugal | Cantanhede | Ferreira LL |
| Portugal | Porto | Coxito Pedro |
| Portugal | Coimbra | Carvalho Eugenia |
| Romania | Timisoara | Muntean Danina M |
| Romania | Timisoara | Lighezan R |
| Singapore | Singapore | Hausenloy Derek J |
| Slovakia | Bratislava | Sumbalova Zuzana |
| Slovakia | Bratislava | Ukropcova B |
| Slovakia | Bratislava | Maderova D |
| Slovakia | Bratislava | Nemec Michal |
| Slovakia | Bratislava | Ukropec J |
| Slovenia | Ljubljana | Pirkmajer Sergej |
| Slovenia | Ljubljana | Dolinar K |
| Slovenia | Ljubljana | Mars T |
| South Africa | Smith James | |
| Spain | Barcelona | De la Torre Lara J |
| Spain | Sevilla | Bustos Matilde |
| Spain | Barcelona | Gama Perez Pau |
| Spain | Armilla (Granada) | Acuna-Castroviejo Dario |
| Spain | A Coruña | Blanco FJ |
| Spain | Barcelona | Batlle M |
| Spain | Armilla (Granada) | Fernandez-Ortiz Marisol |
| Spain | Barcelona | Guitart M |
| Spain | Armilla, Granada | Escames Germaine |
| Spain | Barcelona | Garcia-Roves Pablo Miguel |
| Spain | Granada | Lopez Garcia Luis Carlos |
| Spain | Madrid | Moran M |
| Spain | Barcelona | Sebastian D |
| Spain | Madrid | Cadenas S |
| Spain | Barcelona | Catalan M |
| Spain | Barcelona | Zorzano Antonio |
| Sweden | Stockholm | Cardinale Daniele A |
| Sweden | Linköping | Fontes-Oliveira CC |
| Switzerland | Lausanne | Morato Fornaguera L |
| Switzerland | Lausanne | Sandi Carmen |
| Switzerland | Lausanne | Weger M |
| Switzerland | Bern | Nuoffer Jean-Marc |
| Switzerland | Lausanne | Zalachoras I |
| Switzerland | Lausanne | Gebara E |
| The Netherlands | BT Amsterdam | Wuest Rob CI |
| The Netherlands | Wageningen | Van der Ende Miranda |
| Turkey | Ankara | Tuncay Erkan |
| USA | Gainesville | Hepple Russell T |
| USA | St Louis | Welch R |
| USA | Orlando | Distefano Giovanna |
| USA | College Station | Latham C |
| USA | Gainesville | Neyroud D |
| USA | Boca Raton | Khamoui Andy V |
| USA | Little Rock | Porter Craig |
| USA | Orlando | Coen Paul M |
| USA | Gainesville | Wohlgemuth Stephanie E |
| USA | Baton Rouge | Axelrod Christopher L |
| USA | Torrance | Rossiter Harry B |
| USA | Fort Collins | Chicco Adam J |
| USA | Baton Rouge | Irving Brian A |
| USA | Chicago | Dayanidhi Sudarshan |
| USA | Fairbanks | O'Brien Kristin |
| USA | Baltimore | Gonzalez-Freire Marta |
| USA | College Station | White-Springer Sarah H |
| USA | Colorado Springs | Jacobs RA |
| USA | Baltimore | Fang Evandro F |
| USA | Ann Arbor | Beard Daniel A |
| USA | Norfolk | Lai Nicola |
| United Kingdom | Cambridge | Murray Andrew James |
| United Kingdom | Birmingham | Joanisse S |
| United Kingdom | London | Szabadkai Gyorgy |
| United Kingdom | Manchester | Giakoumaki I |
| United Kingdom | Birmingham | Garten Antje |
| United Kingdom | Birmingham | Thakker A |
| United Kingdom | Nottingham | Chakrabarti Lisa |
| United Kingdom | Loughborough | Ebanks Brad |
| United Kingdom | Leeds | Boyle JP |
| United Kingdom | Plymouth, Devon | McKenna Helen T |
| United Kingdom | Birmingham | Ashcroft S |
| United Kingdom | Oxford | Makrecka-Kuka Marina |
| United Kingdom | Brighton | Moore Anthony L |
| United Kingdom | Cambridge | Shiroma Jonathan G |
| United States | Providence | Siamwala J |
WG2 Management
Tasks
- Call for participating labs to deliver relevant experimental data on already published studies and to report them in a standardized format.
- Collection and indexing of the data sets as required for statistical analysis.
- Discussion of procedures, protocols and general guidelines.
- Draft a comprehensive review on mt-function in muscle tissue (registration at PROSPERO, link with EQUATOR).
- Opening of the database to the research public for data search and moderated entry of new data sets.
Milestones
- Call for data report delivered.
- Data sets entered in standardized format.
- Summary, interpretation and discussion of data for review.
Deliverables
- A MITOEAGLE database on muscle tissue from humans and model organisms.
- A set of guidelines for future studies on mitochondrial bioenergetics in muscle tissue.
- Draft of review manuscript.
Projects in progress
- » MiPMap
