Miller 2006 FEBS Lett: Difference between revisions
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|abstract=Organ failure induced by endotoxic shock has recently been associated with affected mitochondrial function. In this study, effects of ''in vivo'' lipopolysaccharide-challenge on protein patterns of rat liver mitochondria in treated animals versus controls were studied by two-dimensional electrophoresis (differential image gel electrophoresis). Significant upregulation was found for ATP-synthase Ξ± chain and superoxide dismutase [Mn]. Our data suggest that endotoxic shock mediated changes in the mitochondrial proteome contribute to a compensatory reaction (adaptation to endotoxic shock) rather than to a mechanism of cell damage. | |abstract=Organ failure induced by endotoxic shock has recently been associated with affected mitochondrial function. In this study, effects of ''in vivo'' lipopolysaccharide-challenge on protein patterns of rat liver mitochondria in treated animals versus controls were studied by two-dimensional electrophoresis (differential image gel electrophoresis). Significant upregulation was found for ATP-synthase Ξ± chain and superoxide dismutase [Mn]. Our data suggest that endotoxic shock mediated changes in the mitochondrial proteome contribute to a compensatory reaction (adaptation to endotoxic shock) rather than to a mechanism of cell damage. | ||
|keywords=Mitochondria, Proteomics, Lipopolysaccharide, Endotoxic shock, ATP-synthase, Superoxide dismutase | |keywords=Mitochondria, Proteomics, Lipopolysaccharide, Endotoxic shock, ATP-synthase, Superoxide dismutase | ||
|mipnetlab= | |mipnetlab=AT Vienna Kozlov AV | ||
|discipline=Biomedicine | |discipline=Biomedicine | ||
}} | }} |
Revision as of 14:18, 20 March 2015
Miller I, Gemeiner M, Gesslbauer B, Kungl A, Piskernik C, Haindl S, NΓΌrnberger S, Bahrami S, Redl H, Kozlov AV (2006) Proteome analysis of rat liver mitochondria reveals a possible compensatory response to endotoxic shock. FEBS Lett 580:1257-62. |
Miller I, Gemeiner M, Gesslbauer B, Kungl A, Piskernik C, Haindl S, Nuernberger S, Bahrami S, Redl H, Kozlov AV (2006) FEBS Lett
Abstract: Organ failure induced by endotoxic shock has recently been associated with affected mitochondrial function. In this study, effects of in vivo lipopolysaccharide-challenge on protein patterns of rat liver mitochondria in treated animals versus controls were studied by two-dimensional electrophoresis (differential image gel electrophoresis). Significant upregulation was found for ATP-synthase Ξ± chain and superoxide dismutase [Mn]. Our data suggest that endotoxic shock mediated changes in the mitochondrial proteome contribute to a compensatory reaction (adaptation to endotoxic shock) rather than to a mechanism of cell damage. β’ Keywords: Mitochondria, Proteomics, Lipopolysaccharide, Endotoxic shock, ATP-synthase, Superoxide dismutase
β’ O2k-Network Lab: AT Vienna Kozlov AV
Labels:
Stress:Mitochondrial disease Organism: Rat Tissue;cell: Liver
Coupling state: OXPHOS
HRR: Oxygraph-2k