Difference between revisions of "BAM15"
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{{MitoPedia | {{MitoPedia | ||
|abbr= | |abbr=BAM 15 | ||
|description='''2,4- | |description='''2-fluorophenyl){6-[(2-fluorophenyl)amino](1,2,5-oxadiazolo[3,4-e]pyrazin-5-yl)}amine''' is a protonophore or uncoupler of [[Oxidative phosphorylation|oxidative phosphorylation]] detected in a screen for uncoupling agents exerting less toxicity than commonly used uncouplers and first described by [[Kenwood 2013 Mol Metab|Kennwood et al. 2013]]. In their comparative study using BAM 15 and FCCP it was shown to increase oxygen flux to a similar extent as the classical uncoupler, to display a much broader range of concentrations inducing maximum respiration, to elicit no formation of H2O2, to leave cellular membrane potential unaffected, and to ultimately exert less cytotoxicity. | ||
|info=[[ | |info=[[Kenwood 2013 Mol Metab]] | ||
|type=Uncoupler | |type=Uncoupler | ||
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|type=Uncoupler | |type=Uncoupler | ||
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Revision as of 15:08, 21 May 2014
- high-resolution terminology - matching measurements at high-resolution
BAM15
Description
2-fluorophenyl){6-[(2-fluorophenyl)amino](1,2,5-oxadiazolo[3,4-e]pyrazin-5-yl)}amine is a protonophore or uncoupler of oxidative phosphorylation detected in a screen for uncoupling agents exerting less toxicity than commonly used uncouplers and first described by Kennwood et al. 2013. In their comparative study using BAM 15 and FCCP it was shown to increase oxygen flux to a similar extent as the classical uncoupler, to display a much broader range of concentrations inducing maximum respiration, to elicit no formation of H2O2, to leave cellular membrane potential unaffected, and to ultimately exert less cytotoxicity.
Abbreviation: BAM 15
Reference: Kenwood 2013 Mol Metab
MitoPedia topics: Uncoupler
