O2k-Publications: Neuroblastoma

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Neuroblastoma (NB) cell lines are transformed, neural crest derived cells, capable of unlimited proliferation in vitro. These cell lines retain the ability of differentiation into neuronal cell types on treatment with various agents. This ability of NB cells to proliferate as well as to differentiate makes it an excellent in vitro system for various studies.

SH-SY5Y cells are a human derived cell line. The original cell line, called SK-N-SH, from which it was subcloned, was isolated from a bone marrow biopsy taken from a four year-old female with neuroblastoma.

Other human neuroblastoma cell lines: LAN-1, IMR-32 (N-type) and SK-N-AS (S-type).

Mouse neuroblastoma cell line: Neuro 2a

in progress SH-EP and STA-NB15 neuronal cells