From Bioblast
News and Events | Working Groups | Short-Term Scientific Missions | Management Committee | Members |
COST Action CA15203 (2016-2021): MitoEAGLE
Evolution-Age-Gender-Lifestyle-Environment: mitochondrial fitness mapping
Meszaros Andras T
MitoPedia topics: EAGLE
COST WG4: WG4
COST ECI: ECI
Name | Mészáros András T, MD, PhD |
---|---|
Institution |
Mitochondrial Medicine Visionary
Departement of Visceral-Transplant and Thoracic Surgery
|
Address | Anichstraße 35, 6020 |
City | Innsbruck |
State/Province | |
Country | Austria |
[email protected] | |
Weblink | https://www.researchgate.net/profile/Andras_Meszaros2
https://www.chirurgie-innsbruck.at/en/team/d/87/dr-andras-meszaros |
O2k-Network Lab | AT Innsbruck Oroboros, AT Innsbruck Schneeberger S, HU Szeged Boros M |
Labels:
Field of research: Basic
Topics: hypoxia, reoxygenation, electrophyl methyl groups (EMGs), methane, long-chain fatty acids
Publications
Published | Reference | |
---|---|---|
Meszaros 2024 Transpl Int | 2024 | Meszaros AT, Weissenbacher A, Schartner M, Egelseer-Bruendl T, Hermann M, Unterweger J, Mittelberger C, Reyer BA, Hofmann J, Zelger BG, Hautz T, Resch T, Margreiter C, Maglione M, Komlódi T, Ulmer H, Cardini B, Troppmair J, Öfner D, Gnaiger E, Schneeberger S, Oberhuber R (2024) The predictive value of graft viability and bioenergetics testing towards the outcome in liver transplantation. Transpl Int 37:12380. https://doi.org/10.3389/ti.2024.12380 |
Meszaros 2022 EBioMedicine | 2022 | Meszaros AT, Hofmann J, Buch ML, Cardini B, Dunzendorfer-Matt T, Nardin F, Blumer MJ, Fodor M, Hermann M, Zelger B, Otarashvili G, Schartner M, Weissenbacher A, Oberhuber R, Resch T, Troppmair J, Öfner D, Zoller H, Tilg H, Gnaiger E, Hautz T, Schneeberger S (2022) Mitochondrial respiration during normothermic liver machine perfusion predicts clinical outcome. EBioMedicine 85:104311. https://doi.org/10.1016/j.ebiom.2022.104311 |
Bastos Sant'Anna Silva 2021 Cancers (Basel) | 2021 | Bastos Sant'Anna Silva AC, Perez Valencia JA, Sciacovelli M, Lalou C, Sarlak S, Tronci L, Nikitopoulou E, Meszaros AT, Frezza C, Rossignol R, Gnaiger E, Klocker H (2021) Succinate anaplerosis has an onco-driving potential in prostate cancer cells. Cancers 13:1727. https://doi.org/10.3390/cancers13071727 |
BEC 2020.1 doi10.26124bec2020-0001.v1 | 2020 | Gnaiger E et al ― MitoEAGLE Task Group (2020) Mitochondrial physiology. Bioenerg Commun 2020.1. https://doi.org/10.26124/bec:2020-0001.v1 |
Di Marcello 2019 MitoFit Preprint Arch EA | 2019 | Di Marcello M, Iglesias-Gonzalez J, Meszaros A, Haider M, Gnaiger E, Huete-Ortega M (2019) Partitioning between cytochrome c oxidase and alternative oxidase studied by oxygen kinetics of dark respiration in Chlamydomonas reinhardtii: a microalgae model organism. https://doi.org/10.26124/mitofit:ea19.MiPSchool.0005.v3 |
Rutai 2019 Shock | 2019 | Rutai A, Fejes R, Juhász L, Tallósy SP, Poles MZ, Földesi I, Mészáros AT, Szabó A, Boros M, Kaszaki J (2019) Endothelin A and B receptors: Potential pargets for microcirculatory-mitochondrial therapy in experimental sepsis. Shock 54:87-95. |
Doerrier 2018 Methods Mol Biol | 2018 | Doerrier C, Garcia-Souza LF, Krumschnabel G, Wohlfarter Y, Mészáros AT, Gnaiger E (2018) High-Resolution FluoRespirometry and OXPHOS protocols for human cells, permeabilized fibers from small biopsies of muscle, and isolated mitochondria. Methods Mol Biol 1782:31-70. https://doi.org/10.1007/978-1-4939-7831-1_3 |
Rademann 2017 Oxid Med Cell Longev | 2017 | Rademann P, Weidinger A, Drechsler S, Meszaros A, Zipperle J, Jafarmadar M, Dumitrescu S, Hacobian A, Ungelenk L, Röstel F, Kaszaki J, Szabo A, Skulachev VP, Bauer M, Bahrami S, Weis S, Kozlov AV, Osuchowski MF (2017) Mitochondria-targeted antioxidants SKQ1 and MitoTEMPO failed to exert a long-term beneficial effect in murine polymicrobial sepsis. Oxid Med Cell Longev 6412682. |
Tuboly 2017 Sci Rep | 2017 | Tuboly E, Molnár R, Tőkés T, Turányi RN, Hartmann P, Mészáros AT, Strifler G, Földesi I, Siska A, Szabó A, Mohácsi Á, Szabó G, Boros M (2017) Excessive alcohol consumption induces methane production in humans and rats. Sci Rep 7:7329. |
Strifler 2016 PLOS ONE | 2016 | Strifler G, Tuboly E, Szél E, Kaszonyi E, Cao C, Kaszaki J, Mészáros A, Boros M, Hartmann P (2016) Inhaled methane limits the mitochondrial electron transport chain dysfunction during experimental liver ischemia-reperfusion injury. PLOS ONE 11:e0146363. |
Strifler 2016 Magyar Sebeszet | 2016 | Strifler G, Meszaros A, Pecz D, Ficzere A, Barath B, Mihaly B, Hartmann P (2016) A májfunkció vizsgálata respirometriával - Examination of liver mitochondria with respirometry. Magyar Sebészet 69:194–8. |
Abstracts
Published | Reference | |
---|---|---|
Meszaros 2022 Abstract Bioblast | 2022 | 6.6. «5 min» Meszaros Andras T, Hofmann J, Gnaiger E, Oberhuber R, Hautz T, Öfner D, Schneeberger S (2022) Pre-transplant mitochondrial respiration as a clinical prognostic marker during static cold storage and machine perfusion of the liver. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001 |
Bastos Sant'Anna Silva 2019 Life Sciences Meeting 2019 Innsbruck AT | 2019 | Cellular succinate transport and mitochondrial respiratory function in prostate cancer. |
Rutai 2019 Crit Care | 2019 | Rutai A, Fejes R, Tallósy SZ, Poles M, Juhász L, Mészáros A, Boros M, Kaszaki J (2019) Potential role of endothelin receptors in the therapy of experimental sepsis. Crit Care. |
Meszaros 2018 Mt Med Hinxton | 2018 | High-resolution mitochondrial oxygen kinetics as diagnostic tool in Complex IV impairments. |
Meszaros 2018 EBEC2018 | 2018 | Tissue- and substrate-specific patterns in the oxygen kinetics of mitochondrial respiration. |
Bastos Sant'Anna Silva 2018 TRANSMIT Bertinoro di Romagna IT | 2018 | Cellular succinate transport and mitochondrial respiratory function in prostate cancer. |
Bastos Sant'Anna Silva 2018 MiPschool Tromso C4 | 2018 | Role of succinate in prostate cancer cells: uptake and mitochondrial respiratory function. |
Bastos Sant'Anna Silva 2018 Life Sciences Meeting 2018 Innsbruck AT | 2018 | Effect of cell-permeable succinate and malonate prodrugs on mitochondrial respiration in prostate cancer cells. |
Meszaros 2017 MiPschool Obergurgl | 2017 | (Very) High-resolution respirometry – a deep dive into oxygen dependence of mitochondrial respiration. |
Meszaros 2017 MiP2017 | 2017 | Mitochondrial oxygen kinetics as a sensitive diagnostic tool to determine apparent cytochrome c oxidase excess capacity. |
Meszaros 2014 Abstract MiP2014 | 2014 | Methodological aspects of assessing mitochondrial function in small intestinal mucosal samples of rats and guinea pigs. |
MitoEAGLE Short-Term Scientific Mission
- Motivation letter
- My name is András Mészáros and I am working as associate professor in the Institute of Surgical Research at the University of Szeged, Hungary. I got my M.D. degree in 2012 and I was working as PhD fellow in the same institute for three years subsequently before taking the current position. My main research interest is to understand mitochondrial dysfunction during oxido-reductive stress conditions (hypoxia, ischemia-reperfusion) in animal models and cultured cells. My further aim is to characterize acting mechanism of novel biologically active gaseous compounds in mitochondria. I have been working with High Resolution Respirometry and basic fluorometry for three years, gaining experience maínly with tissue homogenate and isolated mitochondría. An essential step now is to extend my expertise toward assessment of other functions than oxygen consumption.
- The main objective of the planned STSM training is to get acquainted with and to standardize fluorometric measurements of isolated mitochondria and cultured cells. During the 8 days of short-term visit at the MitoFit Laboratory three new techniques could be learned:(l) measurement of reactive oxygen species production of permeabilized cells using H2O2-sensitive fluorescent probes; (2) determination of mitochondrial membrane potential and (3) assessment of mitochondrial phosphate/oxygen ratio by measuring ATP levels fluorometrically. Preparation and execution of each method will be learned with emphasis on internal quality control and possible adaptation of measurement protocols to samples from various tissues. Furthermore, we are going to use tools of complex data analysis and calibration.
- Fulfillment of the proposed research plan during the STSM training would contribute significantly to the objectives of the MitoEAGLE Working Group 1 (standardization of protocols in respirometry).I wish to actively participate in the MitoEAGLE project, in, among others, establishing and testing reference protocols to provide basis for comparison of results obtained in various laboratories. To this end, a short stay at the MitoFit Laboratory of Oroboros Instruments could provide a perfect platform having up-to-date instrumental background, well established measurement protocols and top level proficiency.
- Motivation letter
- STSM request: download pdf
MitoEAGLE
- Benefits for COST and for the COST Action MitoEAGLE
- I am working mainly with immune cells from blood and liver mitochondria, while enterocytes and epithelial cells are the major targets of my plans for the next few months.
Participated at
- Bioblast 2022: BEC Inaugural Conference
- Life Science PhD Meeting 2019 Innsbruck AT
- DSL Retreat 2019 Innsbruck AT
- TRANSMIT Kick-off meeting 2018 Bologna IT
- MitoEAGLE 2018 Innsbruck AT
- EBEC2018 Budapest HU
- IOC132 Budapest HU
- Mitochondrial Medicine 2018 Hinxton UK
- IOC128 Cambridge UK
- IOC127 Szeged HU
- MitoFit Workshop ATP 2017 Innsbruck AT
- MitoEAGLE 2017 Hradec Kralove CZ
- IOC124 Schroecken AT
- MiPschool 2017 Obergurgl AT
- MitoFit Open Seminar 2017 Innsbruck AT
- IOC116 Innsbruck AT
- MiP2014 Obergurgl AT
- IOC80 Schroecken AT
- IOC79 Obergurgl AT
Visiting scientist in the Oroboros O2k-Laboratory
András Mészáros : Visiting scientist at the Oroboros O2k-Laboratory
- 2016, November 21 to 28