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COST Action CA15203 (2016-2021): MitoEAGLE
Evolution-Age-Gender-Lifestyle-Environment: mitochondrial fitness mapping
Koopman Werner JH
MitoPedia topics: EAGLE
COST: Member
COST WG4: WG4 COST Mentor: Mentor
Name | Koopman Werner JH, PhD |
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Institution |
Department of Pediatrics, Cellular Bioenergetics group, RIMLS, RCMM, Radboud University Nijmegen Medical Centre, NL Human and Animal Physiology, Wageningen University & Research, NL |
Address | PO Box 9101, 6500, |
City | Nijmegen |
State/Province | |
Country | Netherlands |
[email protected] | |
Weblink | Nijmegen Centre for Molecular Life Sciences; https://www.radboudumc.nl/en/people/werner-koopman |
O2k-Network Lab | NL Nijmegen Koopman WJH |
Bioenergetics Communications
- Werner Koopman is Associate Editor of the journal Bioenergetics Communications
- Keywords: mitochondrial morphofunction, redox metabolism, mitochondrial disorders, quantitative microscopy, intervention
Participated at
Labels:
Publications
Published | Reference | |
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Hoogstraten 2023 Arch Toxicol | 2023 | Hoogstraten CA, Jacobs MME, de Boer G, van de Wal MAE, Koopman WJH, Smeitink JAM, Russel FGM, Schirris TJJ (2023) Metabolic impact of genetic and chemical ADP/ATP carrier inhibition in renal proximal tubule epithelial cells. https://doi.org/10.1007/s00204-023-03510-7 |
Krabbendam 2020 Cell Death Dis | 2020 | Krabbendam IE, Honrath B, Dilberger B, Iannetti EF, Branicky RS, Meyer T, Evers B, Dekker FJ, Koopman WJH, Beyrath J, Bano D, Schmidt M, Bakker BM, Hekimi S, Culmsee C, Eckert GP, Dolga AM (2020) SK channel-mediated metabolic escape to glycolysis inhibits ferroptosis and supports stress resistance in C. elegans. Cell Death Dis 11:263. |
BEC 2020.1 doi10.26124bec2020-0001.v1 | 2020 | Gnaiger E et al ― MitoEAGLE Task Group (2020) Mitochondrial physiology. Bioenerg Commun 2020.1. https://doi.org/10.26124/bec:2020-0001.v1 |
Bajzikova 2019 Cell Metab | 2019 | Bajzikova M, Kovarova J, Coelho AR, Boukalova S, Oh S, Rohlenova K, Svec D, Hubackova S, Endaya B, Judasova K, Bezawork-Geleta A, Kluckova K, Chatre L, Zobalova R, Novakova A, Vanova K, Ezrova Z, Maghzal GJ, Magalhaes Novais S, Olsinova M, Krobova L, An YJ, Davidova E, Nahacka Z, Sobol M, Cunha-Oliveira T, Sandoval-Acuña C, Strnad H, Zhang T, Huynh T, Serafim TL, Hozak P, Sardao VA, Koopman Werner JH, Ricchetti M, Oliveira PJ, Kolar F, Kubista M, Truksa J, Dvorakova-Hortova K, Pacak K, Gurlich R, Stocker R, Zhou Y, Berridge MV, Park S, Dong L, Rohlena J, Neuzil J (2019) Reactivation of dihydroorotate dehydrogenase-driven pyrimidine biosynthesis restores tumor growth of respiration-deficient cancer cells. Cell Metab 29:399-416. 10.1016/j.cmet.2018.10.014 |
Koopman 2016 EMBO Mol Med | 2016 | Koopman WJ, Beyrath J, Fung CW, Koene S, Rodenburg RJ, Willems PH, Smeitink JA (2016) Mitochondrial disorders in children: toward development of small-molecule treatment strategies. EMBO Mol Med 8:311-27. |
Iannetti 2016 Nat Protoc | 2016 | Iannetti EF, Smeitink JA, Beyrath J, Willems PH, Koopman WJ (2016) Multiplexed high-content analysis of mitochondrial morphofunction using live-cell microscopy. Nat Protoc 11:1693-710. |
Willems 2015 Cell Metab | 2015 | Willems PH, Rossignol R, Dieteren CE, Murphy MP, Koopman WJH (2015) Redox homeostasis and mitochondrial dynamics. Cell Metab 22:207-18. |
Schirris 2015 Cell Metab | 2015 | Schirris TJ, Renkema GH, Ritschel T, Voermans NC, Bilos A, van Engelen BG, Brandt U, Koopman WJ, Beyrath JD, Rodenburg RJ, Willems PH, Smeitink JA, Russel FG (2015) Statin-induced myopathy is associated with mitochondrial complex III inhibition. Cell Metab 22:399-407. |
Grefte 2015 Biochim Biophys Acta | 2015 | Grefte S, Wagenaars JA, Jansen R, Willems PH, Koopman WJ (2015) Rotenone inhibits primary murine myotube formation via Raf-1 and ROCK2. Biochim Biophys Acta 1853:1606-14. |
Schoeckel 2015 Cancer Metab | 2015 | Schöckel L, Glasauer A, Basit F, Bitschar K, Truong H, Erdmann G, Algire C, Hägebarth A, Willems PH, Kopitz C, Koopman WJ, Héroult M (2015) Targeting mitochondrial complex I using BAY 87-2243 reduces melanoma tumor growth. Cancer Metab 3:11. |
Liemburg-Apers 2015 Biophys J | 2015 | Liemburg-Apers DC, Schirris TJ, Russel FG, Willems PH, Koopman WJ (2015) Mitoenergetic dysfunction triggers a rapid compensatory increase in steady-state glucose flux. Biophys J 109:1372-86. |
Blanchet 2015 Sci Rep | 2015 | Blanchet L, Smeitink JA, van Emst-de Vries SE, Vogels C, Pellegrini M, Jonckheere AI, Rodenburg RJ, Buydens LM, Beyrath J, Willems PH, Koopman WJ (2015) Quantifying small molecule phenotypic effects using mitochondrial morpho-functional fingerprinting and machine learning. Sci Rep 5:8035. |
Forkink 2014 Biochim Biophys Acta | 2014 | Forkink M, Manjeri GR, Liemburg-Apers DC, Nibbeling E, Blanchard M, Wojtala A, Smeitink JA, Wieckowski MR, Willems PH, Koopman WJ (2014) Mitochondrial hyperpolarization during chronic Complex I inhibition is sustained by low activity of Complex II, III, IV and V. Biochim Biophys Acta 1837:1247-56. |
Willems 2013 Antioxid Redox Signal | 2013 | Willems P, Wanschers BF, Esseling J, Szklarczyk R, Kudla U, Duarte I, Forkink M, Nooteboom M, Swarts H, Gloerich J, Nijtmans L, Koopman W, Huynen MA (2013) BOLA1 is an aerobic protein that prevents mitochondrial morphology changes induced by glutathione depletion. Antioxid Redox Signal 18:129-38. |
Breuer 2013 Neurobiol Dis | 2013 | Breuer ME, Koopman WJ, Koene S, Nooteboom M, Rodenburg RJ, Willems PH, Smeitink JA (2013) The role of mitochondrial OXPHOS dysfunction in the development of neurologic diseases. Neurobiol Dis 51:27-34. https://doi.org/10.1016/j.nbd.2012.03.007 |
Koopman 2012 N Engl J Med | 2012 | Koopman WJ, Willems PH, Smeitink JA (2012) Monogenic mitochondrial disorders. N Engl J Med 366:1132-41. |
Distelmaier 2012 Antioxid Redox Signal | 2012 | Distelmaier F, Valsecchi F, Forkink M, van Emst-de Vries S, Swarts HG, Rodenburg RJ, Verwiel ET, Smeitink JA, Willems PH, Koopman WJ (2012) Trolox-sensitive reactive oxygen species regulate mitochondrial morphology, oxidative phosphorylation and cytosolic calcium handling in healthy cells. Antioxid Redox Signal 17:1657-69. |
Dieteren 2011 Proc Natl Acad Sci U S A | 2011 | Dieteren CE, Gielen SC, Nijtmans LG, Smeitink JA, Swarts HG, Brock R, Willems PH, Koopman WJ (2011) Solute diffusion is hindered in the mitochondrial matrix. Proc Natl Acad Sci U S A 108:8657-62. |
Heeman 2011 J Cell Sci | 2011 | Heeman B, Van den Haute C, Aelvoet SA, Valsecchi F, Rodenburg RJ, Reumers V, Debyser Z, Callewaert G, Koopman WJ, Willems PH, Baekelandt V (2011) Depletion of PINK1 affects mitochondrial metabolism, calcium homeostasis and energy maintenance. J Cell Sci 124:1115-25. |
Koene 2011 J Inherit Metab Dis | 2011 | Koene S, Willems PH, Roestenberg P, Koopman WJ, Smeitink JA (2011) Mouse models for nuclear DNA-encoded mitochondrial complex I deficiency. J Inherit Metab Dis 34:293-307. https://doi.org/10.1007/s10545-009-9005-x |
Koopman 2010 Antioxid Redox Signal | 2010 | Koopman WJ, Nijtmans LG, Dieteren CE, Roestenberg P, Valsecchi F, Smeitink JA, Willems PH (2010) Mammalian mitochondrial complex I: biogenesis, regulation, and reactive oxygen species generation. Antioxid Redox Signal 12:1431-70. |
Distelmaier 2009 Brain | 2009 | Distelmaier F, Koopman WJ, van den Heuvel LP, Rodenburg RJ, Mayatepek E, Willems PH, Smeitink JA (2009) Mitochondrial Complex I deficiency: from organelle dysfunction to clinical disease. Brain 132:833-42. |
Eisenberg 2008 Hum Mol Genet | 2008 | Eisenberg I, Novershtern N, Itzhaki Z, Becker-Cohen M, Sadeh M, Willems PH, Friedman N, Koopman WJ, Mitrani-Rosenbaum S (2008) Mitochondrial processes are impaired in hereditary inclusion body myopathy. Hum Mol Genet 17:3663-74. |
Mortiboys 2008 Ann Neurol | 2008 | Mortiboys H, Thomas KJ, Koopman WJ, Klaffke S, Abou-Sleiman P, Olpin S, Wood NW, Willems PH, Smeitink JA, Cookson MR, Bandmann O (2008) Mitochondrial function and morphology are impaired in parkin-mutant fibroblasts. Ann Neurol 64:555-65. |
Boxma 2005 Nature | 2005 | Boxma B, de Graaf RM, van der Staay GW, van Alen TA, Ricard G, Gabaldón T, van Hoek AH, Moon-van der Staay SY, Koopman WJ, van Hellemond JJ, Tielens AG, Friedrich T, Veenhuis M, Huynen MA, Hackstein JH (2005) An anaerobic mitochondrion that produces hydrogen. Nature 434:74-9.. |
Abstracts
Published | Reference | |
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Koopman 2022 Abstract Bioblast | 2022 | 7.7. «10+5» Bulthuis EP, Einer C, Distelmaier F, Groh L, van Emst-de Vries SE, van de Westerlo E, van de Wal M, Wagenaars J, Rodenburg RJ, Smeitink JAM, Riksen NP, Willems PGHM, Adjobo-Hermans MJW, Zischka H, Koopman Werner JH (2022) The decylTPP mitochondria-targeting moiety lowers electron transport system supercomplex levels in primary human skin fibroblasts. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001 |
Koopman 2017 Abstract MITOEAGLE Barcelona | 2017 | Standardized quantification of mitochondrial morphology and function in living patient fibroblasts using microscopy. Koopman_Presentation |
Koopman 2017 MiPschool Obergurgl | 2017 | Mitochondrial function and dysfunction: ROS detection and redox analysis. Koopman_Presenation |
Iannetti 2015 Abstract MiP2015 | 2015 | High-Content Screening of mitochondrial morphofunction in living cells. |
Koopman 2015 Abstract MiP2015 | 2015 | Mitoenergetic dysfunction triggers a rapid compensatory increase in steady-state glucose flux. |
Wojtala 2014 Abstract MiP2014 | 2014 | Proteomic analysis of mitochondrial Complex I deficient mouse model - impact of Complex I deficiency on p66Shc-Ser36 phosphorylation pathway in NDUFS4-/- mouse tissues. |
Koopman 2014 Abstract MiP2014 | 2014 | Redox regulation of mitochondrial dynamics and function. |
Wagenaars 2014 Abstract IOC 2014-04 Schroecken | 2014 | Wagenaars J, Willems PHGM, Koopman WJ (2014) Oxygen consumption in OXPHOS-deficient cells. Mitochondr Physiol Network 19.02. |
Grefte 2014 Abstract MiP2014 | 2014 | Myotube formation does not require mitochondrial ATP production but is inhibited by rotenone via the Rho-associated, coiled-coil containing protein kinase II. |
Koopman 2013 Abstract MiP2013 | 2013 | Koopman WJH (2013) Developing novel treatment strategies for mitochondrial disease. Mitochondr Physiol Network 18.08. |
Tronstad 2012 Abstract Bioblast | 2012 | Nikolaisen J, Nilsson LIH, Hagland HR, Koopman WJ, Tronstad KJ (2012) Mitochondrial morphology and biogenesis in cellular stress. Mitochondr Physiol Network 17.12. |
Koopman 2012 Abstract Bioblast | 2012 | Koopman WJ (2012) Cellular consequences of mitochondrial dysfunction. Mitochondr Physiol Network 17.12. |