Sauer 1973 FEBS Lett: Difference between revisions

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{{Publication
{{Publication
|title=Sauer LA (1973) Mitochondrial NAD-dependent malic enzyme: a new regulatory enzyme. FEBS Lett 33: 251-5.  
|title=Sauer LA (1973) Mitochondrial NAD-dependent malic enzyme: a new regulatory enzyme. FEBS Lett 33:251-5.
|info=[http://www.ncbi.nlm.nih.gov/pubmed/4147096 PMID: 4147096 Open Access]
|info=[http://www.ncbi.nlm.nih.gov/pubmed/4147096 PMID: 4147096 Open Access]
|authors=Sauer LA
|authors=Sauer LA
|year=1973
|year=1973
|journal=FEBS Lett
|journal=FEBS Lett
|abstract=Electrophoretic evidence for multimolecular forms of malic enzyme (EC 1.1.1.40, NADP-malic dehydrogenase, decarboxylating) was reported by Henderson in 1966 [ 1]. Subsequent purification and assay by spectrophotometric and other methods revealed that malic enzyme isoenzymes were present in cytosol and mitochondrial fractions derived from several different animal tissues [2-61. Of particular importance were the recent findings of Frenkel [7] that the mitochondrial isoenzyme has allosteric properties, and that succinate was a positive modulator. Here, we demonstrate that calf adrenal cortex mitochondria contain an NAD-dependent malic enzyme (EC 1.1.1.39) with regulatory properties. Fumarate was a positive and ATP a negative modulator. The enzyme also reduced NADP but only at about one-quarter of the rate of NAD reduction. These kinetic properties suggest that this enzyme is an important regulator of the rate of malate oxidation.
}}
}}
== Made history ==
::::* [[Mitochondria and bioblasts: Made history]]
::::* [[Malic enzyme]]
== Cited by ==
{{Template:Cited by Gnaiger 2020 BEC MitoPathways}}
{{Labeling
{{Labeling
|organism=Bovines
|additional=Made history, BEC 2020.2
|tissues=Nervous system
|preparations=Enzyme
|additional=Malic enzyme, Made history
}}
}}

Latest revision as of 09:59, 6 July 2022

Publications in the MiPMap
Sauer LA (1973) Mitochondrial NAD-dependent malic enzyme: a new regulatory enzyme. FEBS Lett 33:251-5.

» PMID: 4147096 Open Access

Sauer LA (1973) FEBS Lett

Abstract:

Made history

Cited by

Gnaiger 2020 BEC MitoPathways
Gnaiger E (2020) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 5th ed. Bioenerg Commun 2020.2. https://doi.org/10.26124/bec:2020-0002



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Made history, BEC 2020.2 

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