MiP2014 Programme

MiP2014: alphabetical list of all presentations; further options for sorting: MiP2014 Abstracts MiPMap

• Oral = 10 + 5 min: All talks are 10 min plus 5 min discussion. The invited lecturers provide generously an opportunity to a majority of MiPparticipants to present their work orally, from senior scientists to students.
• P-flash = 5 + 2 min: Flash presentations or poster flashes are 5 min plus 2 min discussion. You may optionally present your work in addition as a poster (please confirm until August 24, if you choose to bring a poster; poster space will be limited).
• Poster = Poster presentation: Posters are up during the entire conference, providing an excellent opportunity for person-to-person discussions and for integrating your work into discussions in the plenary sessions.

^* Further information - what is a P-flash? - Make full use of the MiPMap?

A: Mitochondrial respiratory control

A1: From genotype to mitochondrial phenotypes in health and disease

	Session	Presentation	MiP areas	Mammals;models	Tissues;cells	Stress conditions	Pathological states
Pesta 2014 Abstract MiP 2014	A1 Oral	Dysregulation of muscle ATP synthesis in hypophosphatemic mouse models and in a patient with hypophosphatemia due to a mutation in NaPi2c.	Exercise physiology;nutrition;life style Patients	Human Mouse	Skeletal muscle		Diabetes
Picard 2014 Abstract MiP2014	A1 Oral	Quantitative regulation of nuclear gene expression by mitochondrial DNA heteroplasmy.	mtDNA;mt-genetics mt-Medicine Patients		Other cell lines
Wojtala 2014 Abstract MiP2014	A1 P-flash	Proteomic analysis of mitochondrial Complex I deficient mouse model - impact of Complex I deficiency on p66Shc-Ser36 phosphorylation pathway in NDUFS4-/- mouse tissues.		Mouse		Oxidative stress;RONS
Zapisek 2014 Abstract MiP2014	A1 Poster	YER077C encodes a novel PPR protein essential for mitochondrial genome expression in Saccharomyces cerevisiae.	mtDNA;mt-genetics	Saccharomyces cerevisiae
Balazova 2014 Abstract MiP2014	A1 Poster	Balanced ratio of anionic mitochondrial phospholipids is important for mitochondrial functions in the yeast Saccharomyces cerevisiae.	Respiration	Saccharomyces cerevisiae		Temperature
Eide 2014 Abstract MiP2014	A1 Oral	Reversible mitochondrial DNA mutagenesis.	mtDNA;mt-genetics	Human	Nervous system Stem cells		Aging;senescence
Holmstroem 2014 Abstract MiP2014	A1 Oral	Homozygous missense mutation in the human NARS2 gene results in reduced homodimerization of mitochondrial AsnRS enzyme in a patient with Alpers syndrome.	mtDNA;mt-genetics mt-Medicine Patients	Human	Fibroblast		Neurodegenerative
Houstek 2014 Abstract MiP2014	A1 Poster	Alteration of structure and function of ATP synthase and cytochrome c oxidase by lack of Fo-a and Cox3 subunits caused by mitochondrial DNA 9205delTA mutation.	mtDNA;mt-genetics mt-Medicine Patients
Kowaltowski 2014 Abstract MiP2014	A1 Oral	Luévano-Martínez LA, Forni FM, dos Santos VT, Souza-Pinto NC, Kowaltowski AJ (2014) Cardiolipin is a key determinant for mitochondrial DNA stability and segregation.	Respiration mt-Membrane mtDNA;mt-genetics	Saccharomyces cerevisiae		Temperature
Kruszewski 2014 Abstract MiP2014	A1 P-flash	Complementation of nuclear-encoded proteins which maintain mitochondrial DNA in S. cerevisiae with homologous proteins from other fungi species.	mtDNA;mt-genetics	Saccharomyces cerevisiae Fungi

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A2: Mitochondrial structure and function: fission and fusion to supercomplexes

	Session	Presentation	MiP areas	Mammals;models	Tissues;cells	Stress conditions	Pathological states
Cherubini 2014 Abstract MiP2014	A2 P-flash	Striatal deregulation of Cdk5 alters mitochondrial dynamics in Huntington’s disease.	mt-Structure;fission;fusion		Nervous system	Mitochondrial disease	Neurodegenerative
Mahdaviani 2014 Abstract MiP2014	A2 Oral	Hormone‐induced mitochondrial fission is utilized by brown adipocytes as an amplification pathway for energy expenditure.	Respiration mt-Structure;fission;fusion mt-Membrane	Mouse	Fat Other cell lines
Shirihai 2014 Abstract MiP2014	A2 Oral	Mitochondrial dynamics and quality control, a conflict of interest.	Respiration mt-Structure;fission;fusion Patients	Human	Fat		Aging;senescence Diabetes Obesity
Trudeau 2014 Abstract MiP2014	A2 P-flash	Role of mitochondrial fusion and motility in distributing young mitochondrial protein and removing old protein from the mitochondrial network.	mt-Structure;fission;fusion
Zorzano 2014 Abstract MiP2014	A2 Oral	Metabolic implications of mitofusin 2 dysfunction.	Respiration mt-Structure;fission;fusion Exercise physiology;nutrition;life style	Mouse	Skeletal muscle		Diabetes Obesity
Jezek 2014 Abstract MiP2014	A2 Oral	Mitochondrial cristae morphology changes: from Hackenbrock to hypoxia.	Respiration mt-Structure;fission;fusion mt-Membrane		Other cell lines	Ischemia-reperfusion
Koopman 2014 Abstract MiP2014	A2 Oral	Redox regulation of mitochondrial dynamics and function.	mt-Structure;fission;fusion mtDNA;mt-genetics			Oxidative stress;RONS

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A3: Mitochondrial competence in the aging population – modalities of exercise

	Session	Presentation	MiP areas	Mammals;models	Tissues;cells	Stress conditions	Pathological states
Coen 2014 Abstract MiP2014	A3 Oral	Exercise improves insulin sensitivity and muscle mitochondrial respiration following Roux-en-Y gastric bypass surgery.	Respiration Exercise physiology;nutrition;life style mt-Medicine Patients	Human	Skeletal muscle		Diabetes
Spendiff 2014 Abstract MiP2014	A3 Oral	Lessons from the master athlete: mitochondrial contributions to aging.	Respiration mtDNA;mt-genetics Exercise physiology;nutrition;life style	Human	Skeletal muscle	Oxidative stress;RONS	Aging;senescence
Wohlwend 2014 Abstract MiP2014	A3 Oral	Exercise modality specific mitochondrial adaptations in skeletal muscle of elderly people.	Respiration mt-Biogenesis;mt-density Exercise physiology;nutrition;life style	Human	Skeletal muscle		Aging;senescence
Dohlmann 2014 Abstract MiP2014	A3 Oral	Mitochondrial adaptations to high-intensity training in young and elderly men and women.	Respiration Exercise physiology;nutrition;life style	Human	Skeletal muscle HeLa Fibroblast		Aging;senescence
Hepple 2014 Abstract MiP2014	A3 Oral	Denervation modulates mitochondrial function when aging muscle atrophy becomes severe: implications for therapeutic intervention.	Respiration Exercise physiology;nutrition;life style mt-Medicine	Human	Skeletal muscle	Cell death Permeability transition Oxidative stress;RONS Mitochondrial disease	Aging;senescence
Larsen 2014 Abstract MiP2014	A3 Oral	The effect of high intensity training on mitochondrial fat oxidation in skeletal muscle and subcutaneous adipose tissue.	Respiration mt-Biogenesis;mt-density Exercise physiology;nutrition;life style	Human	Skeletal muscle Fat		Obesity

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A4: Coupling efficiency and mitochondrial respiratory control

	Session	Presentation	MiP areas	Mammals;models	Tissues;cells	Stress conditions	Pathological states
Bresciani Martins de Andrade 2014 Abstract MiP2014	A4 Oral	Mitochondrial function in white adipose tissue: palmitoleic acid (C16:1n7) treatment enhances white adipocyte oxygen consumption.	Respiration		Fat		Diabetes Obesity
Burtscher 2014 Abstract MiP2014	A4 Oral	Region-specific differences in Complex I- and Complex II-linked respiration in the mouse brain.	Respiration	Mouse	Nervous system
Neufer 2014 Abstract MiP2014	A4 Oral	Assessing ATP production and oxygen consumption simultaneously in permeabilized fibers: ATP/O.	Respiration	Mouse	Skeletal muscle
Schoepf 2014 Abstract MiP2014	A4 Oral	OXPHOS analysis in small prostate biopsies.	Respiration Patients	Human	Genital	Oxidative stress;RONS	Cancer
Gnaiger 2014 Abstract MiP2014	A4 Oral	Cell ergometry: OXPHOS and ET-pathway coupling efficiency.	Respiration
Herbst 2014 Abstract MiP2014	A4 Oral	Analysis of mitochondrial function in multiple brain regions through in situ permeabilization.	Respiration	Mouse	Nervous system
Herminghaus 2014 Abstract MiP2014	A4 Poster	Severity of polymicrobial sepsis modulates mitochondrial function in rat liver.	Respiration mt-Medicine	Rat	Liver		Sepsis

B. Experimental protocols in mitochondrial biochemistry

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B1: Experimental regimes in functional studies of mitochondrial preparations

	Session	Presentation	MiP areas	Mammals;models	Tissues;cells	Stress conditions	Pathological states
MacDonald 2014 Abstract MiP2014	B1 Oral	The mitochondrial enzyme 4-hydroxy-2-oxoglutarate aldolase (HOGA) – involvement in the TCA cycle.	Respiration	Rat	Heart Nervous system Liver Kidney
Perry 2014 Abstract MiP2014	B1 Oral	Evaluation of critical experimental parameters for assessing mitochondrial bioenergetics in permeabilized myofibers.	Respiration Instruments;methods	Human	Skeletal muscle
Sparks 2014 Abstract MiP2014	B1 Oral	NAMPT remodels substrate metabolism in skeletal muscle.	Respiration mt-Biogenesis;mt-density Exercise physiology;nutrition;life style	Mouse	Skeletal muscle
Sumbalova 2014 Abstract MiP2014	B1 Oral	Optimization of malate concentration for high-resolution respirometry: mitochondria from rat liver and brain.	Respiration Instruments;methods	Rat	Nervous system Liver
Volodina 2014 Abstract MiP2014	B1 Oral	Multipotent stromal cells injection improves rat liver regeneration through activation of mitochondrial functions after subtotal hepatectomy.	Respiration	Rat	Liver	Oxidative stress;RONS
Komlodi 2014 Abstract MiP2014	B1 Poster	Methylenblue, an enhancer of mitochondrial substrate-level phosphorylation.	Respiration	Guinea pig	Nervous system	Ischemia-reperfusion	Alzheimer's Parkinson's

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B2: Are mitochondria sources or sinks of reactive oxygen species?

	Session	Presentation	MiP areas	Mammals;models	Tissues;cells	Stress conditions	Pathological states
Holloway 2014 Abstract MiP2014	B2 Oral	Acute diet-induced insulin resistance is associated with increased adipose tissue mitochondrial ROS emissions.	Respiration Exercise physiology;nutrition;life style	Mouse	Fat	Oxidative stress;RONS	Diabetes Obesity
Oparka 2014 Abstract MiP2014	B2 Oral	Investigation of the mitochondrial functions to understand p66Shc and reactive oxygen species interplay in tumor cells.	Respiration	Human		Oxidative stress;RONS	Cancer
Skulachev 2014 Abstract MiP2014	B2 Oral	Mitochondria are sources, rather than sinks, of reactive oxygen species. Effects of mitochondria-targeted antioxidants.	mt-Membrane mt-Medicine Patients	Mouse Rat		Oxidative stress;RONS	Aging;senescence Inherited
Starkov 2014 Abstract MiP2014	B2 Oral	Mitochondria as H2O2 buffering system.				Oxidative stress;RONS
Houghton 2014 Abstract MiP2014	B2 Oral	The effect of bioactive phenolics on chronic mitochondrial stress associated with the onset of diabetes.	Respiration Exercise physiology;nutrition;life style	Human	Liver	Oxidative stress;RONS	Diabetes
Jaburek 2014 Abstract MiP2014	B2 Oral	The role of phospholipase A2γ in the regulation of mitochondrial uncoupling protein 2–dependent antioxidant function.	Respiration		Islet cell;pancreas;thymus	Oxidative stress;RONS	Diabetes

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B3: Hypoxia, respiration and fermentation - mitochondrial physiology in cellular energetics

	Session	Presentation	MiP areas	Mammals;models	Tissues;cells	Stress conditions	Pathological states
Amoedo 2014 Abstract MiP2014	B3 Oral	The metabolic panorama during tumor progression towards malignancy.	Respiration		Other cell lines		Cancer
Rodrigues 2014 Abstract MiP2014	B3 Poster	Bioenergetics’ traits of tongue cancer metastatic cells.	Respiration mt-Biogenesis;mt-density	Mouse	Lymphocyte		Cancer
Sokolova 2014 Abstract MiP2014	B3 Oral	Bioenergetic responses to cyclic hypoxia reveal mitochondrial mechanisms of hypoxia tolerance in marine bivalves.	Respiration Comparative MiP;environmental MiP	Other invertebrates		Ischemia-reperfusion Oxidative stress;RONS
Timon-Gomez 2014 Abstract MiP2014	B3 P-flash	The function of mitochondrial pyruvate carriers in the adaptation of respiration capacity and stress tolerance in yeast.	Respiration Comparative MiP;environmental MiP	Saccharomyces cerevisiae		Oxidative stress;RONS
Grefte 2014 Abstract MiP2014	B3 P-flash	Myotube formation does not require mitochondrial ATP production but is inhibited by rotenone via the Rho-associated, coiled-coil containing protein kinase II.	Respiration Genetic knockout;overexpression Developmental biology	Mouse	Skeletal muscle	Oxidative stress;RONS
Galina 2014 Abstract MiP2014	B3 Oral	Effects of perinatal asphyxia in mitochondria of brain during development of the central nervous system.	Respiration mt-Membrane Developmental biology	Rat	Nervous system	Ischemia-reperfusion Permeability transition
Horscroft 2014 Abstract MiP2014	B3 Oral	Substrate utilisation in the hypoxic heart: a glycolysis/glucose oxidation mismatch?	Respiration	Rat	Heart	Ischemia-reperfusion
Kandashvili 2014 Abstract MiP2014	B3 Poster	Regulation of energy metabolism in human colorectal cancer cells in situ.	Respiration mt-Membrane	Human	Endothelial;epithelial;mesothelial cell		Cancer

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B4: Instrumental platforms: developments and applications in mitochondrial physiology

	Session	Presentation	MiP areas	Mammals;models	Tissues;cells	Stress conditions	Pathological states
Ali 2014 Abstract MiP2014	B4 Oral	Oxygen-consuming and ROS-producing activities in synaptosomes.	Respiration Instruments;methods		Nervous system	Oxidative stress;RONS
Widlund 2014 Abstract MiP2014	B4 Oral	Resveratrol as a double edged sword on mitochondrial function.	Respiration Pharmacology;toxicology		HeLa
Felser 2014 Abstract MiP2014	B4 Oral	Assessing mitochondrial dysfunction in fibroblast cells – a comparison between O2k and multiwell respirometry.	Respiration	Human	Endothelial;epithelial;mesothelial cell HeLa Fibroblast
Harrison 2014 Abstract MiP2014	B4 Oral	The relationship between cytochrome redox state and oxygen consumption in isolated mouse and beef heart mitochondria during hypoxia.	Respiration	Rat Bovines	Heart
Hickey 2014 Abstract MiP2014	B4 Oral	Mitochondrial inefficiencies and anoxic ATP hydrolysis capacities in diabetic rat heart.	Respiration mt-Membrane	Rat	Heart	Ischemia-reperfusion Oxidative stress;RONS	Cardiovascular Diabetes Myopathy
Krumschnabel 2014 Abstract MiP2014	B4 Poster	Simultaneous high-resolution measurement of mitochondrial respiration and hydrogen peroxide production.	Respiration	Mouse	Nervous system	Oxidative stress;RONS

C: Functional diagnosis to intervention

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C1: Blood cells and cultured cells as models for diagnosis of mitochondrial pathologies

	Session	Presentation	MiP areas	Mammals;models	Tissues;cells	Stress conditions	Pathological states
Bristot 2014 Abstract MiP2014	C1 Oral	High-resolution respirometry and bioenergetics evaluation in fibroblasts derived from patients with TP53 germline mutations.	Respiration nDNA;cell genetics mt-Medicine	Human	Fibroblast	Oxidative stress;RONS	Cancer
Brown G 2014 Abstract MiP2014	C1 Oral	Complex I inhibition in microglia and inflammatory neuronal loss.			Nervous system	Oxidative stress;RONS	Aging;senescence Parkinson's
Nagy 2014 Abstract MiP2014	C1 Poster	Investigation of the energy metabolism of microglial cells.	Respiration	Human	Nervous system
Paju 2014 Abstract MiP2014	C1 Oral	Characterization of the effects of pro-inflammatory cytokines on energy metabolism in human myoblasts.	Respiration Patients	Human	Skeletal muscle		Aging;senescence
Pecina 2014 Abstract MiP2014	C1 Oral	Manifestation of mitochondrial disorders of nuclear origin in lymphocytes.	Respiration mt-Medicine Patients	Human	Blood cells Lymphocyte
Eggimann 2014 Abstract MiP2014	C1 Oral	Adaptation to nutrient availability in human fibroblasts with mitochondrial dysfunction: the role of sirtuins.	Respiration mt-Medicine Patients	Human	Fibroblast	Mitochondrial disease
Hahn 2014 Abstract MiP2014	C1 Poster	Validation of oxygen consumption measurements in muscle and fibroblasts from patients with mitochondrial diseases.	Respiration mt-Medicine Patients	Human	Skeletal muscle Fibroblast	Mitochondrial disease

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C2: Integrity of mitochondrial preparations and experimental quality control

	Session	Presentation	MiP areas	Mammals;models	Tissues;cells	Stress conditions	Pathological states
Borutaite 2014 Abstract MiP2014	C2 Oral	Controversies regarding cytochrome c test for mitochondrial membrane integrity.	Respiration mt-Membrane	Rat	Heart Nervous system	Ischemia-reperfusion Permeability transition
Meszaros 2014 Abstract MiP2014	C2 Oral	Methodological aspects of assessing mitochondrial function in small intestinal mucosal samples of rats and guinea pigs.	Respiration Instruments;methods	Rat Guinea pig
Figueira 2014 Abstract MiP2014	C2 Oral	Mitochondrial respiration and calcium transport in rat tissues: conversely from skeletal muscle, heart and brain, isolated liver mitochondria exhibit gender dimorphism in respiratory activity.	Respiration Gender	Rat	Heart Skeletal muscle Nervous system Liver	Permeability transition
Laner 2014 Abstract MiP2014	C2 Poster	Cytochrome c flux control factor as a quality criterion in respiratory OXPHOS analysis in canine permeabilized fibers.	Respiration	Dog	Skeletal muscle
Kane 2014 Abstract MiP2014	C2 Oral	Assessing mitochondrial lactate oxidation in permeabilized skeletal muscle fibers highlights important experimental considerations: malate concentration and the cytochrome c effect.	Respiration	Rat	Skeletal muscle
Lai 2014 Abstract1 MiP2014	C2 Oral	Improved isolation of high quality subsarcolemmal and interfibrillar mitochondria from skeletal muscle.	Respiration	Rat Dog	Heart Skeletal muscle Fibroblast
Lai 2014 Abstract2 MiP2014	C2 Poster	Bioenergetic differences between permeabilized red and white fibers of a non-obese model of type II diabetes.	Respiration mt-Biogenesis;mt-density Exercise physiology;nutrition;life style	Rat	Skeletal muscle		Diabetes Obesity

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C3: Physiological and pharmacological intervention with mitochondrial function

	Session	Presentation	MiP areas	Mammals;models	Tissues;cells	Stress conditions	Pathological states
Alberici 2014 Abstract MiP2014	C3 Poster	Effects of long-chain acyl-CoA synthetase 6 knockdown in primary skeletal muscle cells metabolism.	Respiration Genetic knockout;overexpression	Rat	Skeletal muscle	Oxidative stress;RONS	Diabetes Obesity
Brown DA 2014 Abstract MiP2014	C3 Oral	The cardiolipin-targeting peptide Bendavia preserves post-ischemic mitochondrial energetics by sustaining respiratory supercomplexes.	Respiration mt-Membrane Pharmacology;toxicology	Rat	Heart	Ischemia-reperfusion
Contreras-Ferrat 2014 Abstract MiP2014	C3 Oral	Insulin increases mitochondrial calcium levels regulating both mitochondrial function and intracellular signaling in muscle; this effect is disrupted in fibers from short-term high fat diet fed mice. Mitochondr Physiol Network 19.13.	Exercise physiology;nutrition;life style	Mouse	Skeletal muscle		Diabetes
Maddalena 2014 Abstract MiP2014	C3 Poster	Experimental considerations for evaluating bioenergetic effects of a mitochondria-targeted compound, TPP-IOA.	Respiration Pharmacology;toxicology			Cell death
Roy 2014 Abstract MiP2014	C3 Oral	Differential expression of mitochondrial transporter proteins leads to incomplete fatty acid oxidation and insulin resistance in palmitate-treated muscle cells.	nDNA;cell genetics Exercise physiology;nutrition;life style	Rat	Skeletal muscle		Diabetes
El-Bacha 2014 Abstract MiP2014	C3 Oral	Cytotoxicity of grape pomace extract (Vitis vinifera L.) from Brazilian wine industry in human hepatocarcinoma HepG2 cells.	Respiration Pharmacology;toxicology	Human	Liver	Cell death	Cancer
Ferreira 2014 Abstract MiP2014	C3 Poster	Impairment of bioenergetic parameters induced by acute carnosine administration in skeletal muscle of young rats.		Rat	Skeletal muscle		Inherited
Jana Prado 2014 Abstract MiP2014	C3 P-flash	Defining the role of mitochondrial electron transfer Complex I on the modulation of Ca2+ homeostasis: effects of metformin on cancer cell metabolism. Mitochondr Physiol Network 19.13.	Respiration mt-Membrane Pharmacology;toxicology				Cancer Diabetes
Kabir 2014 Abstract MiP2014	C3 Oral	Declining follicular reserve triggers mitochondrial pathway of granulosa cell apoptosis and accelerates the rate of follicular decay.	mt-Membrane Developmental biology	Rat	Genital	Cell death

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C4: Diagnosis and prevention of mitochondrial dysfunction

	Session	Presentation	MiP areas	Mammals;models	Tissues;cells	Stress conditions	Pathological states
Mracek 2014 Abstract MiP2014	C4 P-flash	Function of mitochondrial energy provision apparatus is compromised in patients with chronic heart failure. Mitochondr Physiol Network 19.13.	Respiration mt-Biogenesis;mt-density Patients	Human	Heart		Cardiovascular
Power 2014 Abstract MiP2014	C4 Oral	The hot heart: cardiac mitochondrial energetics during hyperthermia.	Respiration	Rat	Heart	Permeability transition Temperature
Stiban 2014 Abstract MiP2014	C4 Oral	Very long chain ceramides interfere with C16 ceramide-induced channel formation: rheostatic control of apoptosis.	mt-Membrane			Cell death
Tretter 2014 Abstract MiP2014	C4 Oral	Cool or heat? Bioenergetic and ROS homeostatic approach to therapeutic hypothermia.	Respiration Patients	Guinea pig	Nervous system	Oxidative stress;RONS Temperature
Wieckowski 2014 Abstract MiP2014	C4 P-flash	Understanding the utility and limitations of autopsy samples for mitochondrial studies - evaluation of oxidative stress in the central nervous system of patients with diagnosed or highly probable mitochondrial diseases.	mt-Medicine	Mouse	Nervous system	Oxidative stress;RONS
Iyer 2014 Abstract MiP2014	C4 Oral	Bioenergetics: arts meets gentle science in sickness and in health.	Exercise physiology;nutrition;life style mt-Awareness	Human			Obesity
Kluckova 2014 Abstract MiP2014	C4 Oral	Proximal ubiquinone binding site in mitochondrial respiratory Complex II is a target for vitamin E analog MitoVES, an experimental anti-cancer agent. Mitochondr Physiol Network 19.13.	Respiration mtDNA;mt-genetics		Other cell lines	Cell death Oxidative stress;RONS	Cancer