Hagl 2014 J Alzheimers Dis b: Difference between revisions
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{{Publication | {{Publication | ||
|title=Hagl S, Heinrich M, Kocher A, Schiborr C, | |title=Hagl S, Heinrich M, Kocher A, Schiborr C, Frank J, Eckert GP (2014) Curcumin micelles improve mitochondrial function in a mouse model of Alzheimerโs disease. J Alzheimers Dis 1:80-3. | ||
|authors=Hagl S, Heinrich M, Kocher A, Schiborr C, | |info=[http://www.jpreventionalzheimer.com/all-issues.html?article=39 article 39] | ||
|authors=Hagl S, Heinrich M, Kocher A, Schiborr C, Frank J, Eckert GP | |||
|year=2014 | |year=2014 | ||
|journal= | |journal=J Prevention Alzheimers Dis | ||
|abstract=Preventive strategies for late-onset Alzheimerโs disease (AD) | |abstract=Preventive strategies for late-onset Alzheimerโs disease (AD) | ||
should start early at a prodromal stage. Mitochondrial | should start early at a prodromal stage. Mitochondrial | ||
| Line 23: | Line 24: | ||
micelles are a promising neutraceutical for the prevention of | micelles are a promising neutraceutical for the prevention of | ||
AD. | AD. | ||
|keywords=Curcumin, | |keywords=Curcumin, Bioavailability, Mitochondria, Prevention, Alzheimer | ||
|mipnetlab=DE | |mipnetlab=DE Giessen Eckert GP | ||
}} | }} | ||
{{Labeling | {{Labeling | ||
|area=Respiration, | |area=Respiration, Pharmacology;toxicology | ||
|diseases=Alzheimer's | |||
|organism=Mouse | |organism=Mouse | ||
|tissues=Nervous system | |tissues=Nervous system | ||
| | |preparations=Isolated mitochondria | ||
|couplingstates=LEAK, OXPHOS, ET | |||
|pathways=N, S, CIV, NS, ROX | |||
|instruments=Oxygraph-2k | |instruments=Oxygraph-2k | ||
|additional=Curcumin, | |||
}} | }} | ||
Latest revision as of 04:31, 12 February 2020
| Hagl S, Heinrich M, Kocher A, Schiborr C, Frank J, Eckert GP (2014) Curcumin micelles improve mitochondrial function in a mouse model of Alzheimerโs disease. J Alzheimers Dis 1:80-3. |
ยป article 39
Hagl S, Heinrich M, Kocher A, Schiborr C, Frank J, Eckert GP (2014) J Prevention Alzheimers Dis
Abstract: Preventive strategies for late-onset Alzheimerโs disease (AD) should start early at a prodromal stage. Mitochondrial dysfunction has been found to play an important role in the initiation of both aging and the pathogenesis of Alzheimerโs disease. Curcumin, a widely used spice and food-coloring agent, is a polyphenol derived from the rhizome of Curcuma longa. It is known to have anti-oxidant, anti-inflammatory, and anti-protein-aggregate activities which are usually considered beneficial for mitochondrial function. We assessed brain mitochondrial function and concentrations of soluble Aฮฒ40 in a mouse model of AD (Thy1-APP751SL transgenic mice) after 3- week administration of curcumin micelles. Curcumin micelles are a newly developed formulation that account for increased curcumin bioavailability. Curcumin treatment had positive effects on mitochondrial membrane potential and respiratory control ratio. Additionally, it decreased levels of soluble Aฮฒ40 in brains of Thy1-APPSL transgenic mice. Hence, curcumin micelles are a promising neutraceutical for the prevention of AD. โข Keywords: Curcumin, Bioavailability, Mitochondria, Prevention, Alzheimer
โข O2k-Network Lab: DE Giessen Eckert GP
Labels: MiParea: Respiration, Pharmacology;toxicology
Pathology: Alzheimer's
Organism: Mouse Tissue;cell: Nervous system Preparation: Isolated mitochondria
Coupling state: LEAK, OXPHOS, ET
Pathway: N, S, CIV, NS, ROX
HRR: Oxygraph-2k
Curcumin
