Hagl 2014 J Alzheimers Dis b: Difference between revisions
Beno Marija (talk | contribs) No edit summary |
No edit summary Β |
||
(2 intermediate revisions by 2 users not shown) | |||
Line 25: | Line 25: | ||
AD. | AD. | ||
|keywords=Curcumin, Bioavailability, Mitochondria, Prevention, Alzheimer | |keywords=Curcumin, Bioavailability, Mitochondria, Prevention, Alzheimer | ||
|mipnetlab=DE | |mipnetlab=DE Giessen Eckert GP | ||
}} | }} | ||
{{Labeling | {{Labeling | ||
|area=Respiration, Pharmacology;toxicology | |area=Respiration, Pharmacology;toxicology | ||
|diseases=Alzheimer's | |||
|organism=Mouse | |organism=Mouse | ||
|tissues=Nervous system | |tissues=Nervous system | ||
|preparations=Isolated mitochondria | |preparations=Isolated mitochondria | ||
|couplingstates=LEAK, OXPHOS, ET | |||
|couplingstates=LEAK, OXPHOS, | |||
|pathways=N, S, CIV, NS, ROX | |pathways=N, S, CIV, NS, ROX | ||
|instruments=Oxygraph-2k | |instruments=Oxygraph-2k | ||
|additional=Curcumin, | |||
}} | }} |
Latest revision as of 04:31, 12 February 2020
Hagl S, Heinrich M, Kocher A, Schiborr C, Frank J, Eckert GP (2014) Curcumin micelles improve mitochondrial function in a mouse model of Alzheimerβs disease. J Alzheimers Dis 1:80-3. |
Β» article 39
Hagl S, Heinrich M, Kocher A, Schiborr C, Frank J, Eckert GP (2014) J Prevention Alzheimers Dis
Abstract: Preventive strategies for late-onset Alzheimerβs disease (AD) should start early at a prodromal stage. Mitochondrial dysfunction has been found to play an important role in the initiation of both aging and the pathogenesis of Alzheimerβs disease. Curcumin, a widely used spice and food-coloring agent, is a polyphenol derived from the rhizome of Curcuma longa. It is known to have anti-oxidant, anti-inflammatory, and anti-protein-aggregate activities which are usually considered beneficial for mitochondrial function. We assessed brain mitochondrial function and concentrations of soluble AΞ²40 in a mouse model of AD (Thy1-APP751SL transgenic mice) after 3- week administration of curcumin micelles. Curcumin micelles are a newly developed formulation that account for increased curcumin bioavailability. Curcumin treatment had positive effects on mitochondrial membrane potential and respiratory control ratio. Additionally, it decreased levels of soluble AΞ²40 in brains of Thy1-APPSL transgenic mice. Hence, curcumin micelles are a promising neutraceutical for the prevention of AD. β’ Keywords: Curcumin, Bioavailability, Mitochondria, Prevention, Alzheimer
β’ O2k-Network Lab: DE Giessen Eckert GP
Labels: MiParea: Respiration, Pharmacology;toxicology
Pathology: Alzheimer's
Organism: Mouse Tissue;cell: Nervous system Preparation: Isolated mitochondria
Coupling state: LEAK, OXPHOS, ET
Pathway: N, S, CIV, NS, ROX
HRR: Oxygraph-2k
Curcumin