Gnaiger 1999 Transplant Proc: Difference between revisions
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|organism=Human | |organism=Human | ||
|tissues=Endothelial; Epithelial; Mesothelial Cell | |tissues=Endothelial; Epithelial; Mesothelial Cell | ||
|preparations=Intact | |preparations=Intact cells | ||
|injuries=Ischemia-Reperfusion; Preservation | |||
|couplingstates=OXPHOS | |couplingstates=OXPHOS | ||
|instruments=Oxygraph-2k | |||
|discipline=Mitochondrial Physiology, Biomedicine | |discipline=Mitochondrial Physiology, Biomedicine | ||
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Revision as of 14:48, 7 August 2013
Gnaiger E, Rieger G, Stadlmann S, Amberger A, Eberl T, Margreiter R (1999) Mitochondrial defect in endothelial cold ischemia/reperfusion injury. Transplant Proc 31: 994-995. |
Gnaiger E, Rieger G, Stadlmann S, Amberger A, Eberl T, Margreiter R (1999) Transplant Proc
Abstract: ENDOTHELIAL ischemia/reperfusion injury is critical for organ preservation, yet the mechanisms of intracellular damage are little understood. Permeabilization of the cell membrane disrupts ion homeostasis, leading to secondary mitochondrial defects by influx of high extracellular Ca2+ .1 In contrast, primary mitochondrial damage is due to short-term (4 to 8-hour) cold ischemia/reoxygenation (CIR) of endothelial cells in University of Wisconsin (UW) or histidine-tryptophane-ketoglutarate (HTK) solution, while the cell membrane remains intact.2 This study was designed to further characterize mitochondrial defects in CIR injury of endothelial cells.
โข O2k-Network Lab: AT_Innsbruck_Gnaiger E, AT Innsbruck MitoCom
Labels:
Stress:Ischemia-Reperfusion; Preservation"Ischemia-Reperfusion; Preservation" is not in the list (Cell death, Cryopreservation, Ischemia-reperfusion, Permeability transition, Oxidative stress;RONS, Temperature, Hypoxia, Mitochondrial disease) of allowed values for the "Stress" property. Organism: Human Tissue;cell: Endothelial; Epithelial; Mesothelial Cell"Endothelial; Epithelial; Mesothelial Cell" is not in the list (Heart, Skeletal muscle, Nervous system, Liver, Kidney, Lung;gill, Islet cell;pancreas;thymus, Endothelial;epithelial;mesothelial cell, Blood cells, Fat, ...) of allowed values for the "Tissue and cell" property. Preparation: Intact cells
Coupling state: OXPHOS
HRR: Oxygraph-2k