Apostolopoulou 2021 Sci Adv: Difference between revisions
No edit summary |
No edit summary |
||
Line 2: | Line 2: | ||
|title=Apostolopoulou M, Mastrototaro L, Hartwig S, Pesta D, Straรburger K, de Filippo E, Jelenik T, Karusheva Y, Gancheva S, Markgraf D, Herder C, Nair KS, Reichert AS, Lehr S, Mรผssig K, Al-Hasani H, Szendroedi J, Roden M (2021) Metabolic responsiveness to training depends on insulin sensitivity and protein content of exosomes in insulin-resistant males. Sci Adv 7:eabi9551. | |title=Apostolopoulou M, Mastrototaro L, Hartwig S, Pesta D, Straรburger K, de Filippo E, Jelenik T, Karusheva Y, Gancheva S, Markgraf D, Herder C, Nair KS, Reichert AS, Lehr S, Mรผssig K, Al-Hasani H, Szendroedi J, Roden M (2021) Metabolic responsiveness to training depends on insulin sensitivity and protein content of exosomes in insulin-resistant males. Sci Adv 7:eabi9551. | ||
|info=[https://pubmed.ncbi.nlm.nih.gov/34623918 PMID: 34623918 Open Access] | |info=[https://pubmed.ncbi.nlm.nih.gov/34623918 PMID: 34623918 Open Access] | ||
|authors=Apostolopoulou Maria, Mastrototaro Lucia, Hartwig Sonja, Pesta Dominik, Straรburger Klaus, de Filippo Elisabetta, Jelenik Tomas, Karusheva Yanislava, Gancheva Sofiya, Markgraf Daniel, Herder Christian, Nair K Sreekumaran, Reichert | |authors=Apostolopoulou Maria, Mastrototaro Lucia, Hartwig Sonja, Pesta Dominik, Straรburger Klaus, de Filippo Elisabetta, Jelenik Tomas, Karusheva Yanislava, Gancheva Sofiya, Markgraf Daniel, Herder Christian, Nair K Sreekumaran, Reichert Andreas S, Lehr Stefan, Muessig Karsten, Al-Hasani Hadi, Szendroedi Julia, Roden Michael | ||
|year=2021 | |year=2021 | ||
|journal=Sci Adv | |journal=Sci Adv |
Revision as of 15:51, 13 October 2021
Apostolopoulou M, Mastrototaro L, Hartwig S, Pesta D, Straรburger K, de Filippo E, Jelenik T, Karusheva Y, Gancheva S, Markgraf D, Herder C, Nair KS, Reichert AS, Lehr S, Mรผssig K, Al-Hasani H, Szendroedi J, Roden M (2021) Metabolic responsiveness to training depends on insulin sensitivity and protein content of exosomes in insulin-resistant males. Sci Adv 7:eabi9551. |
Apostolopoulou Maria, Mastrototaro Lucia, Hartwig Sonja, Pesta Dominik, Straรburger Klaus, de Filippo Elisabetta, Jelenik Tomas, Karusheva Yanislava, Gancheva Sofiya, Markgraf Daniel, Herder Christian, Nair K Sreekumaran, Reichert Andreas S, Lehr Stefan, Muessig Karsten, Al-Hasani Hadi, Szendroedi Julia, Roden Michael (2021) Sci Adv
Abstract: High-intensity interval training (HIIT) improves cardiorespiratory fitness (VO2max), but its impact on metabolism remains unclear. We hypothesized that 12-week HIIT increases insulin sensitivity in males with or without type 2 diabetes [T2D and NDM (nondiabetic humans)]. However, despite identically higher VO2max, mainly insulin-resistant (IR) persons (T2D and IR NDM) showed distinct alterations of circulating small extracellular vesicles (SEVs) along with lower inhibitory metabolic (protein kinase Ce activity) or inflammatory (nuclear factor kB) signaling in muscle of T2D or IR NDM, respectively. This is related to the specific alterations in SEV proteome reflecting down-regulation of the phospholipase C pathway (T2D) and up-regulated antioxidant capacity (IR NDM). Thus, SEV cargo may contribute to modulating the individual metabolic responsiveness to exercise training in humans.
โข Bioblast editor: Plangger M
Labels: MiParea: Respiration
HRR: Oxygraph-2k
2021-10