Pesta D

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Evolution-Age-Gender-Lifestyle-Environment  » COST Action CA15203 Mitochondrial fitness mapping

Pesta D

MitoPedia topics: EAGLE 


Name Pesta Dominik, Mag. PhD
Dominik Pesta

German Diabetes Center

Institute for Clinical Diabetology

Heinrich Heine University Düsseldorf

Address Auf'm Hennekamp 65, 40225
City Duesseldorf
Country Germany
O2k-Network Lab AT Innsbruck Burtscher M, AT Innsbruck OROBOROS, DE Duesseldorf Roden M


MITOEAGLE Outline Jelenik, Pesta, Roden - Tomas Jelenik, Dominik Pesta, Michael Roden (2016).



Published Reference
Pesta 2016 FASEB J 2016 Pesta DH, Tsirigotis DN, Befroy DE, Caballero D, Jurczak MJ, Rahimi Y, Cline GW, Dufour S, Birkenfeld AL, Rothman DL, Carpenter TO, Insogna K, Petersen KF, Bergwitz C, Shulman GI (2016) Hypophosphatemia promotes lower rates of muscle ATP synthesis. FASEB J 30:3378-87.
Laursen 2015 Proc Natl Acad Sci USA 2015 Laursen WJ, Mastrotto M, Pesta D, Funk OH, Goodman JB, Merriman DK, Ingolia N, Shulman GI, Bagriantsev SN, Gracheva EO (2015) Neuronal UCP1 expression suggests a mechanism for local thermogenesis during hibernation. Proc Natl Acad Sci USA 112:1607-12.
Aidt 2013 PLoS Curr 2013 Aidt FH, Nielsen SM, Kanters J, Pesta D, Nielsen TT, Nørremølle A, Hasholt L, Christiansen M, Hagen CM (2013) Dysfunctional mitochondrial respiration in the striatum of the Huntington's disease transgenic R6/2 mouse model. PLoS Curr 5. pii:ecurrents.hd.d8917b4862929772c5a2f2a34ef1c201.
Camporez 2013 Endocrinology 2013 Camporez JP, Jornayvaz FR, Petersen M, Pesta D, Guigni BA, Serr J, Zhang D, Kahn M, Samuel VT, Jurczak MJ, Shulman GI (2013) Cellular mechanisms by which FGF21 improves insulin sensitivity in male mice. Endocrinology 154:3099-109.
Pesta 2012 Methods Mol Biol 2012
Pesta D, Gnaiger E (2012) High-resolution respirometry. OXPHOS protocols for human cells and permeabilized fibres from small biopsies of human muscle. Methods Mol Biol 810:25-58.
Mitophagy 2012 Pesta D (2012) Mitochondrial mitophagy. Mitochondr Physiol Network 2012-05-22.
Sirtuins 2012 Pesta D (2012) Sirtuin family. Mitochondr Physiol Network 2012-06-29.
Robach 2012 Br J Sports Med 2012 Robach P, Siebenmann C, Jacobs R, Rasmussen P, Nordsborg N, Pesta D, Gnaiger E, Diaz V, Christ A, Fiedler J, Crivelli N, Secher NH, Pichon A, Maggiorini M, Lundby C (2012) The role of haemoglobin mass on VO2max following normobaric live high-train low in endurance-trained athletes. Br J Sports Med Jul 12. 46:822-7.
Pesta 2011 Am J Physiol Regul Integr Comp Physiol 2011 Pesta D, Hoppel F, Macek C, Messner H, Faulhaber M, Kobel C, Parson W, Burtscher M, Schocke M, Gnaiger E (2011) Similar qualitative and quantitative changes of mitochondrial respiration following strength and endurance training in normoxia and hypoxia in sedentary humans. Am J Physiol Regul Integr Comp Physiol 301:R1078–87.
Jacobs 2011 J Appl Physiol 2011 Jacobs R, Rasmussen P, Siebenmann C, Díaz V, Pesta D, Gnaiger E, Nordsborg NB, Robach P, Lundby C (2011) Determinants of time trial performance and maximal incremental exercise in highly trained endurance athletes. J Appl Physiol 111:1422–30.


Published Reference
Hoppel 2015 Abstract MiP2015 2015 Effects of ultramarathon performance on mitochondrial respiration in human platelets.
Pesta 2014 Abstract MiP 2014 2014 Dysregulation of muscle ATP synthesis in hypophosphatemic mouse models and in a patient with hypophosphatemia due to a mutation in NaPi2c.
Pesta 2012 Abstract Bioblast 2012 Pesta D, Jamison PR, Zhang D, Jurczak M, Manchem VP, Bhanot S, Samuel V, Shulman GI (2012) Prevention of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotides targeted to mIndy. Mitochondr Physiol Network 17.12.
Pesta 2012 Abstract Bioblast-mtGlobal 2012 Pesta D (2012) Mitochondrial Global Network - From a young investigator's perspective. Mitochondr Physiol Network 17.12.
Pesta 2011Abstract Mitochondrial Medicine-Diagnosis 2011 Pesta D, Wiethuechter A, Karall D, Schocke M, Gnaiger E (2011) Functional mitochondrial diagnosis in a patient suffering from sudden exercise intolerance. Abstract Mitochondrial Medicine Chicago.
Pesta 2011Abstract Mitochondrial Medicine-Training 2011 Pesta D, Hoppel F, Macek C, Messner H, Faulhaber M, Kobel C, Parson W, Burtscher M, Schocke M, Gnaiger E (2011) Mitochondrial improvements after strength, endurance, and intermittend hypoxic training in sedentary humans. A respiratory study on permeabilized muscle fibres. Abstract Mitochondrial Medicine Chicago.
Pesta 2011Abstract ACSM 2011 Pesta D, Jacobs R, Macek C, Hoppel F, Faulhaber M, Lundby C, Burtscher M, Gnaiger E, Schocke M (2011) Investigation of muscle metabolism of the quadriceps via high-resolution respirometry and 31P MRS in connection with a 10 week endurance training. Medicine & Science in Sports & Exercise 43: 71
Burtscher 2011Abstract Mitochondrial Medicine 2011 Burtscher M, Dietrich H, Gatterer H, Gnaiger E, Harrison DK, Karall D, Krismer M, Lass-Floerl C, Parson W, Perkhofer S, Pesta D, Schocke M, Sumbalova Z, Wiethüchter A (2011) Mitochondrial competence. Regional and international cooperation for establishing new standards in functional mitochondrial diagnosis. Abstract Mitochondrial Medicine Chicago.
Pesta 2010 MiP Abstract 2010 Pesta D, Faulhaber M, Burtscher M, Gnaiger E, Schocke M (2010) Investigation of muscle metabolism of the M. quadriceps via 31P MRS and high-resolution respirometry in connection with 10 weeks of strength and endurance training in normoxia and hypoxia. MiP2010.
Pesta 2010 Abstract IOC60 2010 Pesta D, Macek C, Hoppel F, Faulhaber M, Burtscher M, Gnaiger E, Schocke M (2010) The impact of endurance training on muscle oxidative capacity. MiPNet15.10.


Previous address: Department of Radiology, Medical University of Innsbruck, 6020 Innsbruck, Austria


The German Diabetes Center (DDZ) in Düsseldorf has one research focus, which addresses metabolic pathways in various human and animal tissues emphasizing the role of mitochondria in insulin resistance, obesity and diabetes mellitus. The research objectives are to characterize how mitochondrial function, energy, glucose and lipid metabolism change under different physiological and pathophysiological conditions in order to derive potential diagnostic tools and therapeutic targets for the prevention and treatment of diabetes and its complications.
As such, the center has a longstanding reputation in basic, clinical and epidemiological studies in the field of diabetes mellitus and its comorbidities. One key effort of the DDZ is the organization of the German Diabetes Study (GDS), a nationwide long-term prospective multicenter cohort study in patients with new-onset diabetes. This study comprises repetitive detailed phenotyping including anthropometry, insulin secretion and sensitivity testing, biobanks including blood, muscle, skin and adipose tissue specimen, spiroergometry, as well as cognitive and neurological tests. Another long-term study with similar extensive phenotyping including also liver samples addresses the effects of bariatric surgery in obese humans. In addition, research groups at DDZ also examine various transgenic mouse models with altered muscle, liver, and fat metabolism.
Thus, we can provide relevant input into WG 2: MITOEAGLE data repository in muscle and other tissues and WG3: MITOEAGLE data repository on fat tissues and other tissues. With 6 oxygraphs continuously running in our lab, we can further contribute to WG5 MITOEAGLE dissemination and training by organizing scientific meetings and workshops in order to foster collaborative interactions among the member of the COST Action Mitochondrial fitness mapping MITOEAGLE: Evolution - Age - Gender - Lifestyle - Environment.

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