Difference between revisions of "Xing 2022 Atlantis Press"
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Revision as of 08:17, 15 April 2023
| Xing Yunxie (2022) Is genome instability a significant cause of aging? A review. Atlantis Press. https://doi.org/10.2991/assehr.k.220504.260 |
Xing Yunxie (2022) Atlantis Press
Abstract: What is the main cause of aging has been discussed over last decades. Accumulating evidences has indicated that genome instability including mitochondrial DNA in somatic cell played an important role in human aging process. Various sources of damage such as reactive oxygen species and UV radiation can lead to the decrease of DNA robustness. In addition, the erroneous replication and failure in DNA maintenance system is also able to casus mutations and epimutations. In this review we will first summarize the relation between the accumulation of DNA damage and longevity. Then we will review the contribution made by mitochondrial free radical to the aging process. Finally, we will briefly discuss whether the telomere is an eligible biomarker of life span.
• Bioblast editor: Gnaiger E
Correction: FADH2 and Complex II
- FADH2 is shown as the substrate feeding electrons into Complex II (CII). This is wrong and requires correction - for details see Gnaiger (2024).
- Gnaiger E (2024) Complex II ambiguities ― FADH2 in the electron transfer system. J Biol Chem 300:105470. https://doi.org/10.1016/j.jbc.2023.105470 - »Bioblast link«
Labels:
Enzyme: Complex II;succinate dehydrogenase
