https://wiki.oroboros.at/index.php?title=Wei_2020_Cell_Rep&feed=atom&action=history
Wei 2020 Cell Rep - Revision history
2024-03-29T10:45:18Z
Revision history for this page on the wiki
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https://wiki.oroboros.at/index.php?title=Wei_2020_Cell_Rep&diff=244442&oldid=prev
Gnaiger Erich at 02:55, 21 November 2023
2023-11-21T02:55:50Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 02:55, 21 November 2023</td>
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Gnaiger Erich
https://wiki.oroboros.at/index.php?title=Wei_2020_Cell_Rep&diff=208347&oldid=prev
Plangger Mario at 19:41, 15 October 2020
2020-10-15T19:41:46Z
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Plangger Mario
https://wiki.oroboros.at/index.php?title=Wei_2020_Cell_Rep&diff=208346&oldid=prev
Plangger Mario at 19:34, 15 October 2020
2020-10-15T19:34:25Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 19:34, 15 October 2020</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|info=[https://www.ncbi.nlm.nih.gov/pubmed/32997989 PMID: 32997989 Open Access]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|info=[https://www.ncbi.nlm.nih.gov/pubmed/32997989 PMID: 32997989 Open Access]</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>|authors=Wei <del style="font-weight: bold; text-decoration: none;">X</del>, Lu <del style="font-weight: bold; text-decoration: none;">Z</del>, Li <del style="font-weight: bold; text-decoration: none;">L</del>, Zhang <del style="font-weight: bold; text-decoration: none;">H</del>, Sun <del style="font-weight: bold; text-decoration: none;">F</del>, Ma <del style="font-weight: bold; text-decoration: none;">H</del>, Wang <del style="font-weight: bold; text-decoration: none;">L</del>, Hu <del style="font-weight: bold; text-decoration: none;">Y</del>, Yan <del style="font-weight: bold; text-decoration: none;">Z</del>, Zheng <del style="font-weight: bold; text-decoration: none;">H</del>, Yang <del style="font-weight: bold; text-decoration: none;">G</del>, Liu <del style="font-weight: bold; text-decoration: none;">D</del>, Tepel <del style="font-weight: bold; text-decoration: none;">M</del>, Gao <del style="font-weight: bold; text-decoration: none;">P</del>, Zhu <del style="font-weight: bold; text-decoration: none;">Z</del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>|authors=Wei <ins style="font-weight: bold; text-decoration: none;">Xiao</ins>, Lu <ins style="font-weight: bold; text-decoration: none;">Zongshi</ins>, Li <ins style="font-weight: bold; text-decoration: none;">Li</ins>, Zhang <ins style="font-weight: bold; text-decoration: none;">Hexuan</ins>, Sun <ins style="font-weight: bold; text-decoration: none;">Fang</ins>, Ma <ins style="font-weight: bold; text-decoration: none;">Huan</ins>, Wang <ins style="font-weight: bold; text-decoration: none;">Lijuan</ins>, Hu <ins style="font-weight: bold; text-decoration: none;">Yingru</ins>, Yan <ins style="font-weight: bold; text-decoration: none;">Zhencheng</ins>, Zheng <ins style="font-weight: bold; text-decoration: none;">Hongting</ins>, Yang <ins style="font-weight: bold; text-decoration: none;">Gangyi</ins>, Liu <ins style="font-weight: bold; text-decoration: none;">Daoyan</ins>, Tepel <ins style="font-weight: bold; text-decoration: none;">Martin</ins>, Gao <ins style="font-weight: bold; text-decoration: none;">Peng</ins>, <ins style="font-weight: bold; text-decoration: none;"> </ins>Zhu <ins style="font-weight: bold; text-decoration: none;">Zhiming</ins></div></td></tr>
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Plangger Mario
https://wiki.oroboros.at/index.php?title=Wei_2020_Cell_Rep&diff=208345&oldid=prev
Plangger Mario: Created page with "{{Publication |title=Wei X, Lu Z, Li L, Zhang H, Sun F, Ma H, Wang L, Hu Y, Yan Z, Zheng H, Yang G, Liu D, Tepel M, Gao P, Zhu Z (2020) Reducing NADPH synthesis counteracts di..."
2020-10-15T19:32:16Z
<p>Created page with "{{Publication |title=Wei X, Lu Z, Li L, Zhang H, Sun F, Ma H, Wang L, Hu Y, Yan Z, Zheng H, Yang G, Liu D, Tepel M, Gao P, Zhu Z (2020) Reducing NADPH synthesis counteracts di..."</p>
<p><b>New page</b></p><div>{{Publication<br />
|title=Wei X, Lu Z, Li L, Zhang H, Sun F, Ma H, Wang L, Hu Y, Yan Z, Zheng H, Yang G, Liu D, Tepel M, Gao P, Zhu Z (2020) Reducing NADPH synthesis counteracts diabetic nephropathy through restoration of AMPK activity in type 1 diabetic rats. Cell Rep 32:108207.<br />
|info=[https://www.ncbi.nlm.nih.gov/pubmed/32997989 PMID: 32997989 Open Access]<br />
|authors=Wei X, Lu Z, Li L, Zhang H, Sun F, Ma H, Wang L, Hu Y, Yan Z, Zheng H, Yang G, Liu D, Tepel M, Gao P, Zhu Z<br />
|year=2020<br />
|journal=Cell Rep<br />
|abstract=Diabetic nephropathy (DN) is a major complication of diabetes mellitus and a primary cause of end-stage renal failure. Clinical studies indicate that metabolic surgery improves DN; however, the mechanism remains unclear. Here, we report that Roux-en-Y Gastric Bypass (RYGB) surgery significantly blocked and reversed DN without affecting the insulin signaling pathway. This protective role of RYGB surgery is almost blocked by either inhibition or knockout of 5'AMP-activated protein kinase (AMPK) in podocytes. Furthermore, mRNA microarray data reveal that RYGB surgery obviously reduced the gene expression involved in nicotinamide adenine dinucleotide phosphate (NAPDH) synthesis. The expression of a key NADPH synthase, hexose-6-phosphate dehydrogenase (H6PD), was inhibited by the low plasma corticosterone level after surgery. In addition, blocking NAPDH synthesis by knocking down H6PD mimicked the beneficial role of RYGB surgery through activation of AMPK in podocytes. Therefore, this study demonstrates that reducing NADPH production is critical for renal AMPK activation in response to RYGB surgery.<br />
|keywords=AMPK, NADPH, RYGB surgery, Diabetic nephropathy, Podocyte<br />
|editor=[[Plangger M]]<br />
}}<br />
{{Labeling<br />
|area=Respiration<br />
|instruments=Oxygraph-2k<br />
|additional=2020-10<br />
}}</div>
Plangger Mario