Tsansizi 2016 Abstract Mito Xmas Meeting Innsbruck
|PPM1K, novel insights in connecting metabolism and autophagy in the heart.
Metabolic homeostasis is an integral part of cardiac function and mitochondria are the main sources of metabolites and energy in this highly specialized tissue. Indeed, metabolic remodeling is a hallmark of heart failure, and although there are recent insights on the impact of fatty acids and carbohydrates in it, aminoacid metabolism is not yet studied in this context. Additionally, maintaining a healthy pull of mitochondria in the cell by autophagic degradation of the dysfunctional ones is crucial to cardiomyocyte viability. Data from our lab showed a link between PPM1K, a mitochondrial matrix protein phosphatase involved in branched chain aminoacid (BCAA) catabolism and autophagy. PPM1K is known to be highly expressed in cardiac tissue besides low BCAA catabolism levels, and its ablation leads to cardiac impairment. Thus, we are now testing the hypothesis that the PPM1K-dependent regulation of autophagy impacts in cardiac physiology.
- Tsansizi LI, Schrepfer E, Scorrano L
- Venetian Inst Molecular Medicine, Padova, Italy