Tsai 2016 Sci Rep
| Has title::Tsai HH, Chang SC, Chou CH, Weng TP, Hsu CC, Wang JS (2016) Exercise training alleviates hypoxia-induced mitochondrial dysfunction in the lymphocytes of sedentary males. Sci Rep 6:35170. |
» [[Has info::PMID: 27731374 Open Access]]
Was written by::Tsai HH, Was written by::Chang SC, Was written by::Chou CH, Was written by::Weng TP, Was written by::Hsu CC, Was written by::Wang JS (Was published in year::2016) Was published in journal::Sci Rep
Abstract: [[has abstract::This study elucidates how interval and continuous exercise regimens affect the mitochondrial functionality of lymphocytes under hypoxic stress. Sixty healthy sedentary males were randomly assigned to engage in either high-intensity interval training (HIIT, 3 min intervals at 80% and 40% VO2max, n = 20) or moderate-intensity continuous training (MICT, sustained 60% VO2max, n = 20) for 30 min/day, 5 days/week for 6 weeks or were assigned to a control group that did not receive exercise intervention (n = 20). Lymphocyte phenotypes/mitochondrial functionality under hypoxic exercise (HE, 100 W under 12% O2) were determined before and after the various interventions. Before the intervention, HE (i) increased the mobilization of senescent (CD57+/CD28-) lymphocytes into the blood, (ii) decreased the ATP-linked O2 consumption rate (OCR), the reserve capacity of OCR, and the citrate synthase activity in the mitochondria, and (iii) lowered the mitochondrial membrane potential (MP) and elevated the matrix oxidant burden (MOB) of lymphocytes. However, both HIIT and MICT significantly (i) decreased blood senescent lymphocyte counts, (ii) enhanced the mitochondrial OCR with increased citrate synthase and succinate dehydrogenase activities, (iii) increased mitochondrial MP and decreased MOB and (iv) increased the ratio of mitofusin to DRP-1 in lymphocytes after HE. Thus, we concluded that either HIIT or MICT effectively improves lymphocyte mitochondrial functionality by enhancing oxidative phosphorylation and suppressing oxidative damage under hypoxic conditions.]]
• O2k-Network Lab: Was published by MiPNetLab::TW Taoyuan Wang JS
Labels: MiParea: MiP area::Respiration, MiP area::mt-Biogenesis;mt-density, MiP area::mt-Structure;fission;fusion, MiP area::Exercise physiology;nutrition;life style
Stress:Injury and adaptation::Oxidative stress;RONS Organism: Organism::Human
Preparation: Preparation::Intact cells, Preparation::Permeabilized cells
Coupling state: Coupling states::LEAK, Coupling states::OXPHOS, Coupling states::ETS
