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{{Template:Science for Ukraine}}
{{Template:Science for Ukraine}}


  2023 Week 38
  2024 Week 21


*'''Sep- 18 Mo'''
* '''May-20 Mo'''  
:{|
:{|
| width="100" align="center" | [[File:World Mitochondrial Disease Week logo.jpg|130px|link=https://www.mitochondrialdiseaseweek.org/]]
| width="110" align="center" | [[File:MitoPedia.jpg|left|80px|MitoPedia|link=MitoPedia]]
| '''World Mitochondrial Disease Week''' – Sep 18-24<br>
|''' How do I determine the optimal oligomycin concentration for my assay?'''<br>
World Mitochondrial Disease Week raises awareness of mitochondrial disease through educational, fundraising and advocacy activities.<br>
Perform the oligomycin titration test, and adjust your oligomycin concentration to minimize the inhibition of ET capacity. <br>
'''[https://mitochondrialdiseaseweek.org/events/ »See what is happening near you«]'''
- »'''[https://wiki.oroboros.at/index.php/Oligomycin#Omy_titration_test Oligomycin titration test]'''« <br>
<br>
- communicated by »[[Baglivo Eleonora]]« and »[[Schmitt Sabine]]«
<br>
|} 
Our Chinese distributor Huawei came to visit us in Innsbruck today.<br>
----
'''[https://wiki.oroboros.at/index.php/CN_Beijing_Huawei »CN_Beijing_Huawei«]'''<br>
* '''May-21 Tu'''
[[File:Visit Huawei.jpg|250px|Huawei and Oroboros]]  
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* '''May-22 We''' - International Day for Biological Diversity
:{|
| width="100" align="center" |[[Image:O2k-Publications.jpg|70px|link=http://wiki.oroboros.at/index.php/O2k-Publications:_Topics |O2k-Publications in the MiPMap]]
|'''"We have identified a circadian clock phase-dependent change in Complex I coupling efficiency, demonstrating for the first time a mitochondria–clock interaction in the hooded seal."''' <br>
* Ciccone C, Kante F, Folkow LP, Hazlerigg DG, West AC, Wood SH (2024) Circadian coupling of mitochondria in a deep-diving mammal. [[Ciccone 2024 J Exp Biol|»Bioblast link«]]
:from the O2k-Network »[[NO Tromsoe Wood SH]]«
|}
|}


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*'''Sep- 19 Tu'''
* '''May-23 Th'''
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* '''May-24 Fr'''
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'''<big>Next Week</big>'''
2024 Week 22
 
* '''May-27 Mo'''
:{|
:{|
| width="100" align="center" |[[Image:O2k-Publications.jpg|70px|link=http://wiki.oroboros.at/index.php/O2k-Publications:_Topics |O2k-Publications in the MiPMap]]
| width="110" align="center" | [[Image:O2k-Support.jpg|60px|link=http://wiki.oroboros.at/index.php/O2k-Open_Support |O2k-Open Support]][[File:Yellow-take care.png|25px|Info: take care]]
|'''In 1962, the first report of a patient with a mitochondrial disease was published.''' <br>
|'''Same experimental conditions, but different O<sub>2</sub> fluxes in the left and right chambers?'''<br>
* Luft R, Ikkos D, Palmieri G, Ernster L, Afzelius B (1962). A case of severe hypermetabolism of nonthyroid origin with a defect in the maintenance of mitochondrial respiratory control: a correlated clinical, biochemical, and morphological study. [[Luft 1962 J Clin Invest|»Bioblast link«]]
Check for instrumental and operational factors that could be causing O<sub>2</sub> flux differences between the O2k-chambers.  
<br>
- »'''[[Different O2 fluxes in left and right chamber]]'''«<br>
- communicated by »[[Timon-Gomez Alba]]« and »[[Baglivo Eleonora]]«
|}
|}
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*'''Sep- 20 We'''
* '''May-28 Tu'''
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* '''May-29 We'''  
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*'''Sep- 21 Th'''
* '''May-30 Th'''  
:{|
:{|
| width="100" align="center" |[[File:O2k-Network.png|75px|link=https://wiki.oroboros.at/index.php/O2k-Network]]
| width="110" align="center" | [[Image:O2k-Support.jpg|60px|link=http://wiki.oroboros.at/index.php/O2k-Open_Support |O2k-Open Support]][[File:Blue-info.png|25px|Info: improve]]
|'''The first mitochondrial DNA mutations associated with disease were described in 1988.''' <br>
|''' "Harmonization of isolation protocols yielding intact and enzymatically active mitochondria are critical to assess mitochondrial respiratory function"'''<br>
These discoveries were a game changer in the field of mitochondrial diseases. <br>
- »'''[[MiPNet20.06_IsolationMouseHeart-mt|MiPNet20.06 Isolation mouse heart mitochondria]]'''«<br>
* Holt IJ, Harding A E, Morgan-Hughes JA (1988) Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies. [[Holt 1988 Nature|»Bioblast link«]]
- communicated by »[[Cardoso Luiza]]« and »[[Leo Elettra]]«
* Wallace DC, Singh G, Lott MT, Hodge JA, Schurr TG, Lezza AM, Elsas LJ 2nd, Nikoskelainen EK (1988) Mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy. [[Wallace 1988 Science|»Bioblast link«]]
* Zeviani M, Moraes CT, DiMauro S, Nakase H, Bonilla E, Schon EA, Rowland LP (1988) Deletions of mitochondrial DNA in Kearns-Sayre syndrome. [[Zeviani 1988 Neurology|»Bioblast link«]]
|}
|}
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*'''Sep- 22 Fr'''
* '''May-31 Fr'''
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Latest revision as of 09:37, 21 May 2024

Gentle Science
Oroboros declares solidarity against the Russian aggression-war in Ukraine and against all aggression-wars worldwide. -  »More details
A future for Ukraine is the future of its science
2024 Week 21
  • May-20 Mo
MitoPedia
How do I determine the optimal oligomycin concentration for my assay?

Perform the oligomycin titration test, and adjust your oligomycin concentration to minimize the inhibition of ET capacity.
- »Oligomycin titration test« 
- communicated by »Baglivo Eleonora« and »Schmitt Sabine« 


  • May-21 Tu

  • May-22 We - International Day for Biological Diversity
O2k-Publications in the MiPMap "We have identified a circadian clock phase-dependent change in Complex I coupling efficiency, demonstrating for the first time a mitochondria–clock interaction in the hooded seal."
  • Ciccone C, Kante F, Folkow LP, Hazlerigg DG, West AC, Wood SH (2024) Circadian coupling of mitochondria in a deep-diving mammal. »Bioblast link«
from the O2k-Network »NO Tromsoe Wood SH«

  • May-23 Th

  • May-24 Fr

Next Week

2024 Week 22
  • May-27 Mo
O2k-Open SupportInfo: take care Same experimental conditions, but different O2 fluxes in the left and right chambers?

Check for instrumental and operational factors that could be causing O2 flux differences between the O2k-chambers.
- »Different O2 fluxes in left and right chamber«
- communicated by »Timon-Gomez Alba« and »Baglivo Eleonora«


  • May-28 Tu

  • May-29 We

  • May-30 Th
O2k-Open SupportInfo: improve "Harmonization of isolation protocols yielding intact and enzymatically active mitochondria are critical to assess mitochondrial respiratory function"

- »MiPNet20.06 Isolation mouse heart mitochondria«
- communicated by »Cardoso Luiza« and »Leo Elettra«


  • May-31 Fr

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