Talk:Oroboros Laboratory

Picked up - reading and discussion

As we go

• 2017-08-26 Stucki JW, Ineichen EA. Energy dissipation by calcium recycling and the efficiency of calcium transport in rat-liver mitochondria. Eur J Biochem 1974;48:365-75. - pdf

• 2017-07-31 Don't run biomedical science as a business

• 2017-07-19 Article not only about the shipping of frozen PBMC: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3010910/ Velikab (talk)

• 2017-07-11 A very brief comparison of O2k vs. Seahorse: Li 2017 Methodist Debakey Cardiovasc J

The Oroboros high-resolution respirometer ... can perform multiple injections sequentially for substrates and chemicals. This makes the Oroboros more flexible for comparison purposes. >> O2k-Feedback

• 2017-06-19 Gdynia_2016_Nat Commun - Malic enzyme; cancer

• 2017-06-08 Patent of Q-electrode (1988): Dr P.R. Rich, Glynn Res. Ph., Bodmin; European Patent no.85900699.1 Hungerm (talk) 10:18, 21 June 2017 (CEST)

• 2017-06-08 Pre-print publication: Mitochondria are physiologically maintained at close to 50 °C »Bioblast link«

• 2017-06-07 Important new paper for pfi users - Meinild 2017 Acta Physiol (Oxf): Exercise training increases skeletal muscle mitochondrial volume density by enlargement of existing mitochondria and not de novo biogenesis.

• (i) O2k-Network lab; (ii) MitoFit news.

• 2017-05-30 Quote of the day: ".. oligomycin (complex V inhibitor) determines the amount of ATP production is linked to respiration, FCCP (mitochondrial uncoupler) enables measurement of maximal respiratory capacity, while a combination of rotenone (complex I inhibitor) and antimycin A (complex III inhibitor) determines the reserved respiratory capacity." .. and more: "The mitochondrial network is a major site of ATP production through the coupled integration of the electron transport chain (ETC) with oxidative phosphorylation." - Trotta et al (2017) Disruption of mitochondrial electron transport chain function potentiates the pro-apoptotic effects of MAPK inhibition. JBC Papers in Press. Published on May 25, 2017 as Manuscript M117.786442.

What is reserved respiratory capacity?

• 2017-05-22: Komlodi 2017 Neuropharmacology

Various

• The rate of oxygen utilization by cells - interesting review beyond ascorbate topic
• The new science of exercise
• Meta-research: Evaluation and improvement of research methods and practices

Warburg effect

• Warburg O (1956) On the origin of cancer cells. Science 123:309-14.
• Warburg O (1956) On respiratory impairment in cancer cells. Science 124:269-70.
• Vander Heiden MG, Cantley LC, Thompson CB (2009) Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324: 1029-33.
• Kim JW, Dang CV (2006) Cancer’s molecular sweet tooth and the Warburg effect. Cancer Res 66:8927-30.
• Review: http://online.liebertpub.com/doi/full/10.1089/ars.2016.6750
• Review: http://onlinelibrary.wiley.com/doi/10.1111/febs.13402/full

To our editors

• OROBOROS Mitochondrial Research Laboratory was moved to Oroboros MitoFit Laboratory

>> Please check redirects from OROBOROS Mitochondrial Research Laboratory

• OROBOROS MitoLab: visiting scientists was moved to Oroboros MitoFit lab: visiting scientists

>> Please check redirects from OROBOROS MitoLab: visiting scientists

• Rationale: The 'MitoFit Centre of Excellence' or 'MitoFit Core Facility' comprises the Oroboros MitoFit Laboratory and the DSL MitoFit Facility.

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