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List of results

• 2020 PaduaMuscleDays Padua IT  + (2020 PaduaMuscleDays - 30 years of translational research, Vitual Event, 2020)
• Movement and Cognition 2020 Paris FR  + (2020 World conference on Movement and Cognition, Paris, France, 2020)
• EBEC2018 Budapest HU  + (20^th European Bioenergetics Conference 2018, Budapest, Hungary, 2018)
• SHVM 2023 Graz AT  + (20th Annual Meeting of the Society for Heart and Vascular Metabolism (SHVM), Graz, Austria, 2023)
• SFRR 2021 Virtual  + (20th Biennial Meeting of SFRR International, Virtual, 2021)
• International Botanical Congress 2024 Madrid ES  + (20th International Botanical Congress (IBC), Madrid, ES, 2024)
• EBEC2022 Aix-en-Provence FR  + (21^st European Bioenergetics Conference 2022, Aix-en-Provence, France, 2022.)
• EBEC2024 Innsbruck AT  + (22^st European Bioenergetics Conference 2024, Innsbruck, Austria, 2024)
• GFB 2023 Bedoin FR  + (22nd GFB conference, Bedoin, France, 2023)
• 24th Kalorimetrietage 2021 Braunschweig DE  + (24th Kalorimetrietage, Braunschweig, Germany, 2021.)

• 25th Krakow Conference on Endothelium 2017 PL  + (25^th Krakow Conference on Endothelium, Krakow, Poland.)

• SFRR 2018 Auckland NZ  + (26th Meeting for the Society for Free Radical Research Australasia SFRR(A), Auckland, New Zeland, 2018)
• ECSS 2023 Paris FR  + (28^th ECSS Congress, Paris, France, 2023)
• 28th Congress of the Polish Physiological Society 2021 Virtual  + (28th Congress of the Polish Physiological Society, Virtual, 2021)
• FEBS 2022 Mutters AT  + (2^nd FEBS Workshop on Ageing and Regeneration, Mutters, Austria, 2022)
• Cardiovascular Metabolic Disease 2015  + (2nd Annual Conference of the Prevention and Control of Cardiovascular Metabolic Disease, Wuhan, CN; post-conference workshop '''[[MiPNet20.11_IOC102_Wuhan | 102nd Oroboros O2k-Workshop]]'''.)
• Mitochondria-Targeted Drug Development 2022 Boston US  + (2nd Annual Mitochondria-Targeted Drug Development, Boston MA, US, 2022.)
• 2nd International Munich ROS Meeting 2018 Munich DE  + (2nd International Munich ROS Meeting, Munich, Germany, 2018)
• 2nd Mitochondria Conference 2023 Lisbon PT  + (2nd Mitochondria Conference, Lisbon, Portugal, 2023.)
• Pereira 2009 Biochem J  + (3-BrPA (3-bromopyruvate) is an alkylating … 3-BrPA (3-bromopyruvate) is an alkylating agent with antitumoral activity on hepatocellular carcinoma. This compound inhibits cellular ATP production owing to its action on glycolysis and oxidative phosphorylation; however, the specific metabolic steps and mechanisms of 3-BrPA action in human hepatocellular</br>carcinomas, particularly its effects on mitochondrial energetics, are poorly understood. In the present study it was found that incubation of HepG2 cells with a low concentration of 3-BrPA for a short period (150 μMfor 30 min) significantly affected both glycolysis and mitochondrial respiratory functions. The activity of mitochondrial hexokinase was not inhibited by 150 μM 3-BrPA, but this concentration caused more than 70% inhibition of GAPDH (glyceraldehyde-3-phosphate dehydrogenase) and 3-phosphoglycerate kinase activities. Additionally, 3-BrPA treatment significantly impaired lactate production by HepG2 cells, even when glucose was withdrawn from the incubation medium.</br>Oxygen consumption of HepG2 cells supported by either pyruvate/malate or succinate was inhibited when cells were preincubated with 3-BrPA in glucose-free medium. On the other hand, when cells were pre-incubated in glucose-supplemented medium, oxygen consumption was affected only when succinate</br>was used as the oxidizable substrate. An increase in oligomycinindependent</br>respiration was observed in HepG2 cells treated with 3-BrPA only when incubated in glucose-supplemented medium, indicating that 3-BrPA induces mitochondrial proton leakage as well as blocking the electron transport system. The activity</br>of succinate dehydrogenase was inhibited by 70% by 3-BrPA treatment. These results suggest that the combined action of 3- BrPA on succinate dehydrogenase and on glycolysis, inhibiting steps downstream of the phosphorylation of glucose, play an important role in HepG2 cell death.lay an important role in HepG2 cell death.)
• Jardim-Messeder 2012 Int J Biochem Cell Biol  + (3-Bromopyruvate (3BrPA) is an antitumor ag … 3-Bromopyruvate (3BrPA) is an antitumor agent that alkylates the thiol groups of enzymes and has been proposed as a treatment for neoplasias because of its specific reactivity with metabolic energy transducing enzymes in tumor cells. In this study, we show that the sarco/endoplasmic reticulum calcium (Ca²⁺) ATPase (SERCA) type 1 is one of the target enzymes of 3BrPA activity. Sarco/endoplasmic reticulum vesicles (SRV) were incubated in the presence of 1mM 3BrPA, which was unable to inhibit the ATPase activity of SERCA. However, Ca²⁺-uptake activity was significantly inhibited by 80% with 150μM 3BrPA. These results indicate that 3BrPA has the ability to uncouple the ATP hydrolysis from the calcium transport activities. In addition, we observed that the inclusion of 2mM reduced glutathione (GSH) in the reaction medium with different 3BrPA concentrations promoted an increase in 40% in ATPase activity and protects the inhibition promoted by 3BrPA in calcium uptake activity. This derivatization is accompanied by a decrease of reduced cysteine (Cys), suggesting that GSH and 3BrPA increases SERCA activity and transport by pyruvylation and/or S-glutathiolation mediated by GSH at a critical Cys residues of the SERCA.hiolation mediated by GSH at a critical Cys residues of the SERCA.)