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This page provides a simple browsing interface for finding entities described by a property and a named value. Other available search interfaces include the page property search, and the ask query builder.
List of results
- Movement and Cognition 2019 Tel-Aviv IL + (2019 World conference on Movement and Cognition, Tel-Aviv, Israel, 2019)
- 2020 PaduaMuscleDays Padua IT + (2020 PaduaMuscleDays - 30 years of translational research, Vitual Event, 2020)
- Movement and Cognition 2020 Paris FR + (2020 World conference on Movement and Cognition, Paris, France, 2020)
- EBEC2018 Budapest HU + (20<sup>th</sup> European Bioenergetics Conference 2018, Budapest, Hungary, 2018)
- SHVM 2023 Graz AT + (20th Annual Meeting of the Society for Heart and Vascular Metabolism (SHVM), Graz, Austria, 2023)
- SFRR 2021 Virtual + (20th Biennial Meeting of SFRR International, Virtual, 2021)
- International Botanical Congress 2024 Madrid ES + (20th International Botanical Congress (IBC), Madrid, ES, 2024)
- EBEC2022 Aix-en-Provence FR + (21<sup>st</sup> European Bioenergetics Conference 2022, Aix-en-Provence, France, 2022.)
- EBEC2024 Innsbruck AT + (22<sup>st</sup> European Bioenergetics Conference 2024, Innsbruck, Austria, 2024)
- GFB 2023 Bedoin FR + (22nd GFB conference, Bedoin, France, 2023)
- 24th Kalorimetrietage 2021 Braunschweig DE + (24th Kalorimetrietage, Braunschweig, Germany, 2021.)
- 25th Krakow Conference on Endothelium 2017 PL + (25<sup>th</sup> Krakow Conference on Endothelium, Krakow, Poland.)
- SFRR 2018 Auckland NZ + (26th Meeting for the Society for Free Radical Research Australasia SFRR(A), Auckland, New Zeland, 2018)
- ECSS 2023 Paris FR + (28<sup>th</sup> ECSS Congress, Paris, France, 2023)
- 28th Congress of the Polish Physiological Society 2021 Virtual + (28th Congress of the Polish Physiological Society, Virtual, 2021)
- FEBS 2022 Mutters AT + (2<sup>nd</sup> FEBS Workshop on Ageing and Regeneration, Mutters, Austria, 2022)
- Cardiovascular Metabolic Disease 2015 + (2nd Annual Conference of the Prevention and Control of Cardiovascular Metabolic Disease, Wuhan, CN; post-conference workshop '''[[MiPNet20.11_IOC102_Wuhan | 102nd Oroboros O2k-Workshop]]'''.)
- Mitochondria-Targeted Drug Development 2022 Boston US + (2nd Annual Mitochondria-Targeted Drug Development, Boston MA, US, 2022.)
- 2nd International Munich ROS Meeting 2018 Munich DE + (2nd International Munich ROS Meeting, Munich, Germany, 2018)
- 2nd Mitochondria Conference 2023 Lisbon PT + (2nd Mitochondria Conference, Lisbon, Portugal, 2023.)
- Pereira 2009 Biochem J + (3-BrPA (3-bromopyruvate) is an alkylating β¦ 3-BrPA (3-bromopyruvate) is an alkylating agent with antitumoral activity on hepatocellular carcinoma. This compound inhibits cellular ATP production owing to its action on glycolysis and oxidative phosphorylation; however, the specific metabolic steps and mechanisms of 3-BrPA action in human hepatocellular</br>carcinomas, particularly its effects on mitochondrial energetics, are poorly understood. In the present study it was found that incubation of HepG2 cells with a low concentration of 3-BrPA for a short period (150 ΞΌMfor 30 min) significantly affected both glycolysis and mitochondrial respiratory functions. The activity of mitochondrial hexokinase was not inhibited by 150 ΞΌM 3-BrPA, but this concentration caused more than 70% inhibition of GAPDH (glyceraldehyde-3-phosphate dehydrogenase) and 3-phosphoglycerate kinase activities. Additionally, 3-BrPA treatment significantly impaired lactate production by HepG2 cells, even when glucose was withdrawn from the incubation medium.</br>Oxygen consumption of HepG2 cells supported by either pyruvate/malate or succinate was inhibited when cells were preincubated with 3-BrPA in glucose-free medium. On the other hand, when cells were pre-incubated in glucose-supplemented medium, oxygen consumption was affected only when succinate</br>was used as the oxidizable substrate. An increase in oligomycinindependent</br>respiration was observed in HepG2 cells treated with 3-BrPA only when incubated in glucose-supplemented medium, indicating that 3-BrPA induces mitochondrial proton leakage as well as blocking the electron transport system. The activity</br>of succinate dehydrogenase was inhibited by 70% by 3-BrPA treatment. These results suggest that the combined action of 3- BrPA on succinate dehydrogenase and on glycolysis, inhibiting steps downstream of the phosphorylation of glucose, play an important role in HepG2 cell death.lay an important role in HepG2 cell death.)