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- Anderson 2009 J Am Coll Cardiol + (The aim of this study was to determine the … The aim of this study was to determine the impact of diabetes on oxidant balance and mitochondrial metabolism of carbohydrate- and lipid-based substrates in myocardium of type 2 diabetic patients. Background Heart failure represents a major cause of death among diabetic patients. It has been proposed that derangements in cardiac metabolism and oxidative stress may underlie the progression of this comorbidity, but scarce evidence exists in support of this mechanism in humans. Methods Mitochondrial oxygen (O<sub>2</sub>) consumption and hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) emission were measured in permeabilized myofibers prepared from samples of the right atrial appendage obtained from nondiabetic (n=13) and diabetic (n=11) patients undergoing nonemergent coronary artery bypass graft surgery.</br>Results Mitochondria in atrial tissue of type 2 diabetic individuals show a sharply decreased capacity for glutamate and fatty acid-supported respiration, in addition to an increased content of myocardial triglycerides, as compared to nondiabetic patients. Furthermore, diabetic patients show an increased mitochondrial H<sub>2</sub>O<sub>2</sub> emission during oxidation of carbohydrate- and lipid-based substrates, depleted glutathione, and evidence of persistent oxidative stress in their atrial tissue.</br>Conclusions These findings are the first to directly investigate the effects of type 2 diabetes on a panoply of mitochondrial functions in the human myocardium using cellular and molecular approaches, and they show that mitochondria in diabetic human hearts have specific impairments in maximal capacity to oxidize fatty acids and glutamate, yet increased mitochondrial H<sub>2</sub>O<sub>2</sub> emission, providing insight into the role of mitochondrial dysfunction and oxidative stress in the pathogenesis of heart failure in diabetic patients.ght into the role of mitochondrial dysfunction and oxidative stress in the pathogenesis of heart failure in diabetic patients.)
