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- Hypoxia + ('''Hypoxia''' (hypox) is defined in respir … '''Hypoxia''' (hypox) is defined in respiratory physiology as the state when insufficient O<sub>2</sub> is available for respiration, compared to ''environmental'' hypoxia defined as environmental oxygen pressures below the [[normoxic]] reference level. Three major categories of hypoxia are (''1'') environmental hypoxia, (''2'') physiological tissue hypoxia in hyperactivated states (e.g. at ''V''<sub>O<sub>2</sub>max</sub>) with intracellular oxygen demand/supply balance at steady state in tissues at environmental normoxia, compared to tissue normoxia in physiologically balanced states, and (''3'') pathological tissue hypoxia including ischemia and stroke, anaemia, chronic heart disease, chronic obstructive pulmonary disease, severe COVID-19, and obstructive sleep apnea. Pathological hypoxia leads to tissue hypoxia and heterogenous intracellular anoxia. Clinical oxygen treatment ('environmental hyperoxia') may not or only partially overcome pathological tissue hypoxia.al hyperoxia') may not or only partially overcome pathological tissue hypoxia.)
