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- Coupled respiration + ('''Coupled respiration''' drives oxidative … '''Coupled respiration''' drives oxidative phosphorylation of the diphosphate [[ADP]] to the triphosphate [[ATP]], mediated by proton pumps across the inner mitochondrial membrane. Intrinsically [[uncoupled respiration]], in contrast, does not lead to phosphorylation of ADP, despite of protons being pumped across the inner mt-membrane. Coupled respiration, therefore, is the coupled part of respiratory oxygen flux that pumps the fraction of protons across the inner mt-membrane which is utilized by the phosphorylation system to produce ATP from ADP and Pi. In the OXPHOS state, mitochondria are in a partially coupled state, and the corresponding coupled respiration is the [[free OXPHOS capacity]]. In the state of ROUTINE respiration, coupled respiration is the [[free ROUTINE activity]].[[free ROUTINE activity]].)
